@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : AKT3_HUMAN: (2015-10-03 )
MSDVTIVKEGWVQKRGEYIKNWRPRYFLLKTDGSFIGYKEKPQDVDLPYPLNNFSVAKCQLMKTERPKPNTFIIRCLQWTTVIERTFHVDTPEEREEWTEAIQAVADRLQRQEEERMNCSPTSQIDNIGEEEMDASTTHHKRKTMNDFDYLKLLGKGTFGKVILVREKASGKYYAMKILKKEVIIAKDEVAHTLTESRVLKNTRHPFLTSLKYSFQTKDRLCFVMEYVNGGELFFHLSRERVFSEDRTRFYGAEIVSALDYLHSGKIVYRDLKLENLMLDKDGHIKITDFGLCKEGITDAATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEDIKFPRTLSSDAKSLLSGLLIKDPNKRLGGGPDDAKEIMRHSFFSGVNWQDVYDKKLVPPFKPQVTSETDTRYFDEEFTAQTITITPPEKYDEDGMDCMDNERRPHFPQFSYSASGRE
Atome Classification :
(72 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......----140.........150.....-..160.....---..---170----........180...--.-..---.190.......-200--.-.-......210.......220.......230.......-240.........250.......260..-..--...270.......280..----......290.......300..--.-....310.......320---.---........330.......340-.....--.---.----350.......360-----.--....----...370.......380.......390-.-......400.......---410.......420.......430.......440.......450.......460.......470.......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MS
D
V
T
I
V
K
E
G
W
V
Q
K
R
G
E
Y
I
K
NWR
P
R
Y
F
L
L
KTDGSFIGYKEKPQDVDLPYPLNNF
S
V
A
K
C
Q
L
MKTERPKP
N
T
F
I
I
R
C
L
Q
W
T
T
V
I
E
R
TFHVDT
P
E
E
R
E
E
W
T
E
A
I
Q
A
V
A
D
R
L
Q
R
Q
E
E
E
RMNCSP
T
S
Q
I
DNI
G
E
E
EMDASTTH----H--KRKTM
N
D
F
D
Y
L
K
L
LGKG-TFG
K
V
I
L
V
R
E---KA---S-G----
K
Y
Y
A
M
K
I
L
K
K
E
V
I
I--
A
-
K
D
---
E
V
A
H
T
L
T
E
S
R
V
-L-K--N-T-RHP
F
L
T
S
L
K
Y
SFQTKD
R
L
C
F
V
M
E
YVNG
G
E
L
F
F
H
L
S
R
-
E
--RVFSE
D
R
T
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
HS-G
K
--
I
V
Y
R
D
L
K
L
E
N
L
M
LD-KDG----
H
I
K
I
T
D
F
G
L
C
KEGIT
D
A
A
T
M
K
--
T
-FCG
T
P
E
Y
L
A
P
E
VLED-----N---DYGR
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
CG-RLPFY--N---Q----
D
H
E
K
L
F
E
L
I
L
M
E------D--IKFP----R
T
L
S
S
D
A
K
S
L
L
S
G
LLIKDPNKRLGGG-
P
-
D
D
A
K
E
I
M
R
H
S
FFSGV
N
---
W
Q
D
V
YDKKLVPPFKPQVTSETDTRYFDEEFTA
Q
T
I
T
ITPPEKYDEDGMDCMDNERRPHFPQFSYSASGRE
79
HHSearch
92.14
83%
-107
- C1 -
4EJN
3
AKT1_HUMAN
A:
[4-438]
---
V
A
I
V
K
E
G
W
L
H
K
R
G
E
Y
I
K
T
W
R
P
R
Y
F
L
L
K
N
D
G
T
F
I
G
Y
K
E
R
P
------
A
P
L
N
N
F
S
V
A
Q
C
Q
L
M
K
T
E
R
P
R
P
N
T
F
I
I
R
C
L
Q
W
T
T
V
I
E
R
T
F
H
V
E
T
P
E
E
R
E
E
W
T
T
A
I
Q
T
V
A
D
G
---------------------------------------
R
V
T
M
N
E
F
E
Y
L
K
L
L
G
K
G
-
T
F
G
K
V
I
L
V
K
E
---
K
A
---
T
-
G
----
R
Y
Y
A
M
K
I
L
K
K
E
V
I
V
-------------------
V
-
L
-
Q
--
N
-
S
-
R
H
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
-
E
--
R
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
K
N
--
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
-
K
D
G
----
H
I
K
I
T
D
F
G
L
C
K
E
G
I
K
-----
K
--
T
-
F
C
G
T
P
E
Y
L
A
P
E
V
L
E
D
-----
N
---
D
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
-
R
L
P
F
Y
--
N
---
Q
----
D
H
E
K
L
F
E
L
I
L
M
E
------
E
--
I
R
F
P
----
R
T
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
R
L
G
G
G
-
S
-
E
D
A
K
E
I
M
Q
H
R
F
F
A
G
I
V
---
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
P
Q
V
T
S
E
T
D
T
R
Y
F
--------------------------------------------
16
PsiBlast_PDB
85.63
82%
-109
- C1 -
3E87
1
AKT2_HUMAN
A:
[3-335]
-----------------------------------------------------------------------------------------------------------------------------------------------------
T
M
N
D
F
D
Y
L
K
L
L
G
K
G
-
T
F
G
K
V
I
L
V
R
E
---
K
A
---
T
-
G
----
R
Y
Y
A
M
K
I
L
R
K
E
V
I
I
--
A
-
K
D
---
E
V
A
H
T
V
T
E
S
R
V
-
L
-
Q
--
N
-
T
-
R
H
P
F
L
T
A
L
K
Y
A
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
-
E
--
R
V
F
T
E
E
R
A
R
F
Y
G
A
E
I
V
S
A
L
E
Y
L
H
S
-
R
D
--
V
V
Y
R
D
I
K
L
E
N
L
M
L
D
-
K
D
G
----
H
I
K
I
T
D
F
G
L
C
K
E
G
I
S
D
G
A
T
M
K
--
T
-
F
C
G
T
P
E
Y
L
A
P
E
V
L
E
D
-----
N
---
D
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
-
R
L
P
F
Y
--
N
---
Q
----
D
H
E
R
L
F
E
L
I
L
M
E
------
E
--
I
R
F
P
----
R
T
L
S
P
E
A
K
S
L
L
A
G
L
L
K
K
D
P
K
Q
R
L
G
G
G
-
P
-
S
D
A
K
E
V
M
E
H
R
F
F
L
S
I
N
---
W
Q
D
V
V
Q
K
K
L
L
P
P
F
K
P
Q
V
T
S
E
V
D
T
R
Y
F
D
D
E
F
T
A
Q
S
I
T
I
T
P
P
--------------
Q
R
T
H
F
P
Q
F
D
Y
S
A
S
I
R
-
10
PsiBlast_PDB
85.50
85%
-108
- C1 -
4GV1
5
AKT1_HUMAN
A:
[4-337]
---------------------------------------------------------------------------------------------------------------------------------------------------
R
V
T
M
N
E
F
E
Y
L
K
L
L
G
K
G
-
T
F
G
K
V
I
L
V
K
E
---
K
A
---
T
-
G
----
R
Y
Y
A
M
K
I
L
K
K
E
V
I
V
--
A
-
K
D
---
E
V
A
H
T
L
T
E
N
R
V
-
L
-
Q
--
N
-
S
-
R
H
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
-
E
--
R
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
-
E
K
N-
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
-
K
D
G
----
H
I
K
I
T
D
F
G
L
C
K
E
G
I
K
D
G
A
T
M
K
--
T
-
F
C
G
T
P
E
Y
L
A
P
E
V
L
E
D
-----
N
---
D
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
-
R
L
P
F
Y
--
N
---
Q
----
D
H
E
K
L
F
E
L
I
L
M
E
------
E
--
I
R
F
P
----
R
T
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
R
L
G
G
G
-
S
-
E
D
A
K
E
I
M
Q
H
R
F
F
A
G
I
V
---
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
P
Q
V
T
S
E
T
D
T
R
Y
F
D
E
E
F
T
A
Q
M
I
T
I
T
P
-------
S
M
E
C
V
D
S
E
R
R
P
H
F
P
Q
F
D
Y
S
A
S
---
80
HHSearch
85.47
86%
-108
- C1 -
4GV1
5
AKT1_HUMAN
A:
[4-337]
---------------------------------------------------------------------------------------------------------------------------------------------------
R
V
T
M
N
E
F
E
Y
L
K
L
L
G
K
G
-
T
F
G
K
V
I
L
V
K
E
---
K
A
---
T
-
G
----
R
Y
Y
A
M
K
I
L
K
K
E
V
I
V
--
A
-
K
D
---
E
V
A
H
T
L
T
E
N
R
V
-
L
-
Q
--
N
-
S
-
R
H
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
-
E
--
R
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
K
N
--
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
-
K
D
G
----
H
I
K
I
T
D
F
G
L
C
K
E
G
I
K
D
G
A
T
M
K
--
T
-
F
C
G
T
P
E
Y
L
A
P
E
V
L
E
D
-----
N
---
D
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
-
R
L
P
F
Y
--
N
---
Q
----
D
H
E
K
L
F
E
L
I
L
M
E
------
E
--
I
R
F
P
----
R
T
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
R
L
G
G
G
-
S
-
E
D
A
K
E
I
M
Q
H
R
F
F
A
G
I
V
---
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
P
Q
V
T
S
E
T
D
T
R
Y
F
D
E
E
F
T
A
Q
M
I
T
I
T
P
-------
S
M
E
C
V
D
S
E
R
R
P
H
F
P
Q
F
D
Y
S
A
S
---
17
PsiBlast_PDB
84.39
82%
-110
- C1 -
3E88
1
AKT2_HUMAN
A:
[3-335]
-----------------------------------------------------------------------------------------------------------------------------------------------------
T
M
N
D
F
D
Y
L
K
L
L
G
K
G
-
T
F
G
K
V
I
L
V
R
E
---
K
A
---
T
-
G
----
R
Y
Y
A
M
K
I
L
R
K
E
V
I
I
--
A
-
K
D
---
E
V
A
H
T
V
T
E
S
R
V
-
L
-
Q
--
N
-
T
-
R
H
P
F
L
T
A
L
K
Y
A
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
-
E
--
R
V
F
T
E
E
R
A
R
F
Y
G
A
E
I
V
S
A
L
E
Y
L
H
S
-
R
D
--
V
V
Y
R
D
I
K
L
E
N
L
M
L
D
-
K
D
G
----
H
I
K
I
T
D
F
G
L
C
K
E
G
I
S
D
G
A
T
M
K
--
T
-
F
C
G
T
P
E
Y
L
A
P
E
V
L
E
D
-----
N
---
D
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
-
R
L
P
F
Y
--
N
---
Q
----
D
H
E
R
L
F
E
L
I
L
M
E
------
E
--
I
R
F
P
----
R
T
L
S
P
E
A
K
S
L
L
A
G
L
L
K
K
D
P
K
Q
R
L
G
G
G
-
P
-
S
D
A
K
E
V
M
E
H
R
F
F
L
S
I
N
---
W
Q
D
V
V
Q
K
K
L
L
P
P
F
K
P
Q
V
T
S
E
V
D
T
R
Y
F
D
D
E
F
T
A
Q
S
I
T
I
T
----------------
Q
R
T
H
F
P
Q
F
D
Y
S
A
S
I
R
-
29
PsiBlast_CBE
84.36
81%
-109
- C1 -
2JDO
2
AKT2_HUMAN
A:
[8-340]
-----------------------------------------------------------------------------------------------------------------------------------------------------
T
M
N
D
F
D
Y
L
K
L
L
G
K
G
-
T
F
G
K
V
I
L
V
R
E
---
K
A
---
T
-
G
----
R
Y
Y
A
M
K
I
L
R
K
E
V
I
I
--
A
-
K
D
---
E
V
A
H
T
V
T
E
S
R
V
-
L
-
Q
--
N
-
T
-
R
H
P
F
L
T
A
L
K
Y
A
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
-
E
--
R
V
F
T
E
E
R
A
R
F
Y
G
A
E
I
V
S
A
L
E
Y
L
H
S
-
R
D
--
V
V
Y
R
D
I
K
L
E
N
L
M
L
D
-
K
D
G
----
H
I
K
I
T
D
F
G
L
C
K
E
G
I
S
D
G
A
T
M
K
--
T
-
F
C
G
T
P
E
Y
L
A
P
E
V
L
E
D
-----
N
---
D
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
-
R
L
P
F
Y
--
N
---
Q
----
D
H
E
R
L
F
E
L
I
L
M
E
------
E
--
I
R
F
P
----
R
T
L
S
P
E
A
K
S
L
L
A
G
L
L
K
K
D
P
K
Q
R
L
G
G
G
-
P
-
S
D
A
K
E
V
M
E
H
R
F
F
L
S
I
N
---
W
Q
D
V
V
Q
K
K
L
L
P
P
F
K
P
Q
V
T
S
E
V
D
T
R
Y
F
D
D
E
F
T
A
Q
S
I
T
---------------------
M
F
E
D
F
D
Y
I
A
D
W
--
3
PsiBlast_PDB
84.28
85%
-107
- C1 -
3OCB
1
AKT1_HUMAN
A:
[5-338]
---------------------------------------------------------------------------------------------------------------------------------------------------
R
V
T
M
N
E
F
E
Y
L
K
L
L
G
K
G
-
T
F
G
K
V
I
L
V
K
E
---
K
A
---
T
-
G
----
R
Y
Y
A
M
K
I
L
K
K
E
V
I
V
--
A
-
K
D
---
E
V
A
H
T
L
T
E
N
R
V
-
L
-
Q
--
N
-
S
-
R
H
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
-
E
--
R
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
-
E
K
N-
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
-
K
D
G
----
H
I
K
I
T
D
F
G
L
C
K
E
G
I
K
D
G
A
T
M
K
--
T
-
F
C
G
T
P
E
Y
L
A
P
E
V
L
E
D
-----
N
---
D
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
-
R
L
P
F
Y
--
N
---
Q
----
D
H
E
K
L
F
E
L
I
L
M
E
------
E
--
I
R
F
P
----
R
T
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
R
L
G
G
G
-
S
-
E
D
A
K
E
I
M
Q
H
R
F
F
A
G
I
V
---
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
P
Q
V
T
S
E
T
D
T
R
Y
F
D
E
E
F
T
A
Q
M
---------------------
R
P
H
F
P
Q
F
D
Y
S
A
S
S
--
8
PsiBlast_PDB
84.07
85%
-104
- C1 -
4EKK
1
AKT1_HUMAN
A:
[5-338]
---------------------------------------------------------------------------------------------------------------------------------------------------
R
V
T
M
N
E
F
E
Y
L
K
L
L
G
K
G
-
T
F
G
K
V
I
L
V
K
E
---
K
A
---
T
-
G
----
R
Y
Y
A
M
K
I
L
K
K
E
V
I
V
--
A
-
K
D
---
E
V
A
H
T
L
T
E
N
R
V
-
L
-
Q
--
N
-
S
-
R
H
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
-
E
--
R
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
-
E
K
N-
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
-
K
D
G
----
H
I
K
I
T
D
F
G
L
C
K
E
G
I
K
D
G
A
T
M
K
--
T
-
F
C
G
T
P
E
Y
L
A
P
E
V
L
E
D
-----
N
---
D
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
-
R
L
P
F
Y
--
N
---
Q
----
D
H
E
K
L
F
E
L
I
L
M
E
------
E
--
I
R
F
P
----
R
T
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
R
L
G
G
G
-
S
-
E
D
A
K
E
I
M
Q
H
R
F
F
A
G
I
V
---
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
P
Q
V
T
S
E
T
D
T
R
Y
F
D
E
E
F
T
A
Q
M
I
-----------------
S
E
R
R
P
H
F
P
Q
F
D
Y
S
A
S
---
6
PsiBlast_PDB
84.05
85%
-105
- C1 -
3QKL
1
AKT1_HUMAN
A:
[5-338]
---------------------------------------------------------------------------------------------------------------------------------------------------
R
V
T
M
N
E
F
E
Y
L
K
L
L
G
K
G
-
T
F
G
K
V
I
L
V
K
E
---
K
A
---
T
-
G
----
R
Y
Y
A
M
K
I
L
K
K
E
V
I
V
--
A
-
K
D
---
E
V
A
H
T
L
T
E
N
R
V
-
L
-
Q
--
N
-
S
-
R
H
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
-
E
--
R
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
-
E
K
N-
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
-
K
D
G
----
H
I
K
I
T
D
F
G
L
C
K
E
G
I
K
D
G
A
T
M
K
--
T
-
F
C
G
T
P
E
Y
L
A
P
E
V
L
E
D
-----
N
---
D
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
-
R
L
P
F
Y
--
N
---
Q
----
D
H
E
K
L
F
E
L
I
L
M
E
------
E
--
I
R
F
P
----
R
T
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
R
L
G
G
G
-
S
-
E
D
A
K
E
I
M
Q
H
R
F
F
A
G
I
V
---
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
P
Q
V
T
S
E
T
D
T
R
Y
F
D
E
E
F
T
A
Q
M
I
T
-------------------
R
P
H
F
P
Q
F
D
Y
S
A
S
S
--
15
PsiBlast_PDB
84.00
83%
-110
- C1 -
1O6K
1
AKT2_HUMAN
A:
[3-334]
-----------------------------------------------------------------------------------------------------------------------------------------------------
T
M
N
D
F
D
Y
L
K
L
L
G
K
G
-
T
F
G
K
V
I
L
V
R
E
---
K
A
---
T
-
G
----
R
Y
Y
A
M
K
I
L
R
K
E
V
I
I
--
A
-
K
D
---
E
V
A
H
T
V
T
E
S
R
V
-
L
-
Q
--
N
-
T
-
R
H
P
F
L
T
A
L
K
Y
A
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
-
E
--
R
V
F
T
E
E
R
A
R
F
Y
G
A
E
I
V
S
A
L
E
Y
L
H
S
-
R
D
--
V
V
Y
R
D
I
K
L
E
N
L
M
L
D
-
K
D
G
----
H
I
K
I
T
D
F
G
L
C
K
E
G
I
S
D
G
A
T
M
K
--
T
-
F
C
G
T
P
E
Y
L
A
P
E
V
L
E
D
-----
N
---
D
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
-
R
L
P
F
Y
--
N
---
Q
----
D
H
E
R
L
F
E
L
I
L
M
E
------
E
--
I
R
F
P
----
R
T
L
S
P
E
A
K
S
L
L
A
G
L
L
K
K
D
P
K
Q
R
L
G
G
G
-
P
-
S
D
A
K
E
V
M
E
H
R
F
F
L
S
I
N
---
W
Q
D
V
V
Q
K
K
L
L
P
P
F
K
P
Q
V
T
S
E
V
D
T
R
Y
F
D
D
E
F
T
A
Q
S
I
T
------------------
Q
R
T
H
F
P
Q
F
D
Y
S
A
S
I
--
27
PsiBlast_CBE
83.88
81%
-109
- C1 -
2UW9
1
AKT2_HUMAN
A:
[8-340]
-----------------------------------------------------------------------------------------------------------------------------------------------------
T
M
N
D
F
D
Y
L
K
L
L
G
K
G
-
T
F
G
K
V
I
L
V
R
E
---
K
A
---
T
-
G
----
R
Y
Y
A
M
K
I
L
R
K
E
V
I
I
--
A
-
K
D
---
E
V
A
H
T
V
T
E
S
R
V
-
L
-
Q
--
N
-
T
-
R
H
P
F
L
T
A
L
K
Y
A
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
-
E
--
R
V
F
T
E
E
R
A
R
F
Y
G
A
E
I
V
S
A
L
E
Y
L
H
S
-
R
D
--
V
V
Y
R
D
I
K
L
E
N
L
M
L
D
-
K
D
G
----
H
I
K
I
T
D
F
G
L
C
K
E
G
I
S
D
G
A
T
M
K
--
T
-
F
C
G
T
P
E
Y
L
A
P
E
V
L
E
D
-----
N
---
D
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
-
R
L
P
F
Y
--
N
---
Q
----
D
H
E
R
L
F
E
L
I
L
M
E
------
E
--
I
R
F
P
----
R
T
L
S
P
E
A
K
S
L
L
A
G
L
L
K
K
D
P
K
Q
R
L
G
G
G
-
P
-
S
D
A
K
E
V
M
E
H
R
F
F
L
S
I
N
---
W
Q
D
V
V
Q
K
K
L
L
P
P
F
K
P
Q
V
T
S
E
V
D
T
R
Y
F
D
D
E
F
T
A
Q
S
I
T
-------------------
Q
E
M
F
E
D
F
D
Y
I
A
D
W
--
24
PsiBlast_CBE
83.85
82%
-109
- C1 -
3E8D
1
AKT2_HUMAN
B:
[3-335]
-----------------------------------------------------------------------------------------------------------------------------------------------------
T
M
N
D
F
D
Y
L
K
L
L
G
K
G
-
T
F
G
K
V
I
L
V
R
E
---
K
A
---
T
-
G
----
R
Y
Y
A
M
K
I
L
R
K
E
V
I
I
--
A
-
K
D
---
E
V
A
H
T
V
T
E
S
R
V
-
L
-
Q
--
N
-
T
-
R
H
P
F
L
T
A
L
K
Y
A
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
-
E
--
R
V
F
T
E
E
R
A
R
F
Y
G
A
E
I
V
S
A
L
E
Y
L
H
S
-
R
D
--
V
V
Y
R
D
I
K
L
E
N
L
M
L
D
-
K
D
G
----
H
I
K
I
T
D
F
G
L
C
K
E
G
I
S
D
G
A
T
M
K
--
T
-
F
C
G
T
P
E
Y
L
A
P
E
V
L
E
D
-----
N
---
D
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
-
R
L
P
F
Y
--
N
---
Q
----
D
H
E
R
L
F
E
L
I
L
M
E
------
E
--
I
R
F
P
----
R
T
L
S
P
E
A
K
S
L
L
A
G
L
L
K
K
D
P
K
Q
R
L
G
G
G
-
P
-
S
D
A
K
E
V
M
E
H
R
F
F
L
S
I
N
---
W
Q
D
V
V
Q
K
K
L
L
P
P
F
K
P
Q
V
T
S
E
V
D
T
R
Y
F
D
D
E
F
T
A
Q
S
I
-------------------
Q
R
T
H
F
P
Q
F
D
Y
S
A
S
I
R
-
18
PsiBlast_PDB
83.71
82%
-111
- C1 -
3E8D
1
AKT2_HUMAN
A:
[3-335]
-----------------------------------------------------------------------------------------------------------------------------------------------------
T
M
N
D
F
D
Y
L
K
L
L
G
K
G
-
T
F
G
K
V
I
L
V
R
E
---
K
A
---
T
-
G
----
R
Y
Y
A
M
K
I
L
R
K
E
V
I
I
--
A
-
K
D
---
E
V
A
H
T
V
T
E
S
R
V
-
L
-
Q
--
N
-
T
-
R
H
P
F
L
T
A
L
K
Y
A
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
-
E
--
R
V
F
T
E
E
R
A
R
F
Y
G
A
E
I
V
S
A
L
E
Y
L
H
S
-
R
D
--
V
V
Y
R
D
I
K
L
E
N
L
M
L
D
-
K
D
G
----
H
I
K
I
T
D
F
G
L
C
K
E
G
I
S
D
G
A
T
M
K
--
T
-
F
C
G
T
P
E
Y
L
A
P
E
V
L
E
D
-----
N
---
D
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
-
R
L
P
F
Y
--
N
---
Q
----
D
H
E
R
L
F
E
L
I
L
M
E
------
E
--
I
R
F
P
----
R
T
L
S
P
E
A
K
S
L
L
A
G
L
L
K
K
D
P
K
Q
R
L
G
G
G
-
P
-
S
D
A
K
E
V
M
E
H
R
F
F
L
S
I
N
---
W
Q
D
V
V
Q
K
K
L
L
P
P
F
K
P
Q
V
T
S
E
V
D
T
R
Y
F
D
D
E
F
T
A
Q
S
I
T
---------------------
H
F
P
Q
F
D
Y
S
A
S
I
R
-
13
PsiBlast_PDB
83.69
85%
-104
- C1 -
3MVH
1
AKT1_HUMAN
A:
[7-338]
----------------------------------------------------------------------------------------------------------------------------------------------------
V
T
M
N
E
F
E
Y
L
K
L
L
G
K
G
-
T
F
G
K
V
I
L
V
K
E
---
K
A
---
T
-
G
----
R
Y
Y
A
M
K
I
L
K
K
E
V
I
V
--
A
-
K
D
---
E
V
A
H
T
L
T
E
N
R
V
-
L
-
Q
--
N
-
S
-
R
H
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
-
E
--
R
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
-
E
K
N-
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
-
K
D
G
----
H
I
K
I
T
D
F
G
L
C
K
E
G
I
K
D
G
A
T
M
K
--
T
-
F
C
G
T
P
E
Y
L
A
P
E
V
L
E
D
-----
N
---
D
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
-
R
L
P
F
Y
--
N
---
Q
----
D
H
E
K
L
F
E
L
I
L
M
E
------
E
--
I
R
F
P
----
R
T
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
R
L
G
G
G
-
S
-
E
D
A
K
E
I
M
Q
H
R
F
F
A
G
I
V
---
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
P
Q
V
T
S
E
T
D
T
R
Y
F
D
E
E
F
T
A
Q
----------------------
R
P
H
F
P
Q
F
D
Y
S
A
----
12
PsiBlast_PDB
83.60
85%
-105
- C1 -
3MV5
1
AKT1_HUMAN
A:
[6-339]
---------------------------------------------------------------------------------------------------------------------------------------------------
R
V
T
M
N
E
F
E
Y
L
K
L
L
G
K
G
-
T
F
G
K
V
I
L
V
K
E
---
K
A
---
T
-
G
----
R
Y
Y
A
M
K
I
L
K
K
E
V
I
V
--
A
-
K
D
---
E
V
A
H
T
L
T
E
N
R
V
-
L
-
Q
--
N
-
S
-
R
H
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
-
E
--
R
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
-
E
K
N-
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
-
K
D
G
----
H
I
K
I
T
D
F
G
L
C
K
E
G
I
K
D
G
A
T
M
K
--
T
-
F
C
G
T
P
E
Y
L
A
P
E
V
L
E
D
-----
N
---
D
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
-
R
L
P
F
Y
--
N
---
Q
----
D
H
E
K
L
F
E
L
I
L
M
E
------
E
--
I
R
F
P
----
R
T
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
R
L
G
G
G
-
S
-
E
D
A
K
E
I
M
Q
H
R
F
F
A
G
I
V
---
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
P
Q
V
T
S
E
T
D
T
R
Y
F
D
E
E
F
T
A
Q
M
I
--------------------
R
P
H
F
P
Q
F
D
Y
S
A
S
---
21
PsiBlast_CBE
83.58
85%
-106
- C1 -
4EKK
1
AKT1_HUMAN
B:
[5-338]
---------------------------------------------------------------------------------------------------------------------------------------------------
R
V
T
M
N
E
F
E
Y
L
K
L
L
G
K
G
-
T
F
G
K
V
I
L
V
K
E
---
K
A
---
T
-
G
----
R
Y
Y
A
M
K
I
L
K
K
E
V
I
V
--
A
-
K
D
---
E
V
A
H
T
L
T
E
N
R
V
-
L
-
Q
--
N
-
S
-
R
H
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
-
E
--
R
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
-
E
K
N-
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
-
K
D
G
----
H
I
K
I
T
D
F
G
L
C
K
E
G
I
K
D
G
A
T
M
K
--
T
-
F
C
G
T
P
E
Y
L
A
P
E
V
L
E
D
-----
N
---
D
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
-
R
L
P
F
Y
--
N
---
Q
----
D
H
E
K
L
F
E
L
I
L
M
E
------
E
--
I
R
F
P
----
R
T
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
R
L
G
G
G
-
S
-
E
D
A
K
E
I
M
Q
H
R
F
F
A
G
I
V
---
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
P
Q
V
T
S
E
T
D
T
R
Y
F
D
E
E
F
T
A
Q
M
I
-----------------
S
E
R
R
P
H
F
P
Q
F
D
Y
S
A
S
---
26
PsiBlast_CBE
83.19
81%
-110
- C1 -
2X39
1
AKT2_HUMAN
A:
[8-340]
-----------------------------------------------------------------------------------------------------------------------------------------------------
T
M
N
D
F
D
Y
L
K
L
L
G
K
G
-
T
F
G
K
V
I
L
V
R
E
---
K
A
---
T
-
G
----
R
Y
Y
A
M
K
I
L
R
K
E
V
I
I
--
A
-
K
D
---
E
V
A
H
T
V
T
E
S
R
V
-
L
-
Q
--
N
-
T
-
R
H
P
F
L
T
A
L
K
Y
A
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
-
E
--
R
V
F
T
E
E
R
A
R
F
Y
G
A
E
I
V
S
A
L
E
Y
L
H
S
-
R
D
--
V
V
Y
R
D
I
K
L
E
N
L
M
L
D
-
K
D
G
----
H
I
K
I
T
D
F
G
L
C
K
E
G
I
S
D
G
A
T
M
K
--
T
-
F
C
G
T
P
E
Y
L
A
P
E
V
L
E
D
-----
N
---
D
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
-
R
L
P
F
Y
--
N
---
Q
----
D
H
E
R
L
F
E
L
I
L
M
E
------
E
--
I
R
F
P
----
R
T
L
S
P
E
A
K
S
L
L
A
G
L
L
K
K
D
P
K
Q
R
L
G
G
G
-
P
-
S
D
A
K
E
V
M
E
H
R
F
F
L
S
I
N
---
W
Q
D
V
V
Q
K
K
L
L
P
P
F
K
P
Q
V
T
S
E
V
D
T
R
Y
F
D
D
E
F
T
A
Q
S
I
T
-------------------
Q
E
M
F
E
D
F
D
Y
I
A
D
W
--
20
PsiBlast_PDB
83.14
81%
-110
- C1 -
1O6L
1
AKT2_HUMAN
A:
[3-335]
-----------------------------------------------------------------------------------------------------------------------------------------------------
T
M
N
D
F
D
Y
L
K
L
L
G
K
G
-
T
F
G
K
V
I
L
V
R
E
---
K
A
---
T
-
G
----
R
Y
Y
A
M
K
I
L
R
K
E
V
I
I
--
A
-
K
D
---
E
V
A
H
T
V
T
E
S
R
V
-
L
-
Q
--
N
-
T
-
R
H
P
F
L
T
A
L
K
Y
A
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
-
E
--
R
V
F
T
E
E
R
A
R
F
Y
G
A
E
I
V
S
A
L
E
Y
L
H
S
-
R
D
--
V
V
Y
R
D
I
K
L
E
N
L
M
L
D
-
K
D
G
----
H
I
K
I
T
D
F
G
L
C
K
E
G
I
S
D
G
A
T
M
K
--
T
-
F
C
G
T
P
E
Y
L
A
P
E
V
L
E
D
-----
N
---
D
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
-
R
L
P
F
Y
--
N
---
Q
----
D
H
E
R
L
F
E
L
I
L
M
E
------
E
--
I
R
F
P
----
R
T
L
S
P
E
A
K
S
L
L
A
G
L
L
K
K
D
P
K
Q
R
L
G
G
G
-
P
-
S
D
A
K
E
V
M
E
H
R
F
F
L
S
I
N
---
W
Q
D
V
V
Q
K
K
L
L
P
P
F
K
P
Q
V
T
S
E
V
D
T
R
Y
F
D
D
E
F
T
A
Q
S
I
T
-------------------
Q
E
M
F
E
D
F
D
Y
I
A
D
W
--
22
PsiBlast_CBE
83.05
85%
-107
- C1 -
3OW4
1
AKT1_HUMAN
B:
[5-338]
---------------------------------------------------------------------------------------------------------------------------------------------------
R
V
T
M
N
E
F
E
Y
L
K
L
L
G
K
G
-
T
F
G
K
V
I
L
V
K
E
---
K
A
---
T
-
G
----
R
Y
Y
A
M
K
I
L
K
K
E
V
I
V
--
A
-
K
D
---
E
V
A
H
T
L
T
E
N
R
V
-
L
-
Q
--
N
-
S
-
R
H
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
-
E
--
R
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
-
E
K
N-
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
-
K
D
G
----
H
I
K
I
T
D
F
G
L
C
K
E
G
I
K
D
G
A
T
M
K
--
T
-
F
C
G
T
P
E
Y
L
A
P
E
V
L
E
D
-----
N
---
D
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
-
R
L
P
F
Y
--
N
---
Q
----
D
H
E
K
L
F
E
L
I
L
M
E
------
E
--
I
R
F
P
----
R
T
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
R
L
G
G
G
-
S
-
E
D
A
K
E
I
M
Q
H
R
F
F
A
G
I
V
---
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
P
Q
V
T
S
E
T
D
T
R
Y
F
D
E
E
F
T
A
Q
M
I
T
-------------------
R
P
H
F
P
Q
F
D
Y
S
A
S
S
--
4
PsiBlast_PDB
83.01
85%
-104
- C1 -
3OW4
1
AKT1_HUMAN
A:
[5-338]
---------------------------------------------------------------------------------------------------------------------------------------------------
R
V
T
M
N
E
F
E
Y
L
K
L
L
G
K
G
-
T
F
G
K
V
I
L
V
K
E
---
K
A
---
T
-
G
----
R
Y
Y
A
M
K
I
L
K
K
E
V
I
V
--
A
-
K
D
---
E
V
A
H
T
L
T
E
N
R
V
-
L
-
Q
--
N
-
S
-
R
H
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
-
E
--
R
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
-
E
K
N-
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
-
K
D
G
----
H
I
K
I
T
D
F
G
L
C
K
E
G
I
K
D
G
A
T
M
K
--
T
-
F
C
G
T
P
E
Y
L
A
P
E
V
L
E
D
-----
N
---
D
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
-
R
L
P
F
Y
--
N
---
Q
----
D
H
E
K
L
F
E
L
I
L
M
E
------
E
--
I
R
F
P
----
R
T
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
R
L
G
G
G
-
S
-
E
D
A
K
E
I
M
Q
H
R
F
F
A
G
I
V
---
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
P
Q
V
T
S
E
T
D
T
R
Y
F
D
E
E
F
T
A
Q
M
I
T
-------------------
R
P
H
F
P
Q
F
D
Y
S
A
S
S
--
19
PsiBlast_PDB
82.94
82%
-108
- C1 -
3D0E
1
AKT2_HUMAN
A:
[3-335]
-----------------------------------------------------------------------------------------------------------------------------------------------------
T
M
N
D
F
D
Y
L
K
L
L
G
K
G
-
T
F
G
K
V
I
L
V
R
E
---
K
A
---
T
-
G
----
R
Y
Y
A
M
K
I
L
R
K
E
V
I
I
--
A
-
K
D
---
E
V
A
H
T
V
T
E
S
R
V
-
L
-
Q
--
N
-
T
-
R
H
P
F
L
T
A
L
K
Y
A
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
-
E
--
R
V
F
T
E
E
R
A
R
F
Y
G
A
E
I
V
S
A
L
E
Y
L
H
S
-
R
D
--
V
V
Y
R
D
I
K
L
E
N
L
M
L
D
-
K
D
G
----
H
I
K
I
T
D
F
G
L
C
K
E
G
I
S
D
G
A
T
M
K
--
T
-
F
C
G
T
P
E
Y
L
A
P
E
V
L
E
D
-----
N
---
D
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
-
R
L
P
F
Y
--
N
---
Q
----
D
H
E
R
L
F
E
L
I
L
M
E
------
E
--
I
R
F
P
----
R
T
L
S
P
E
A
K
S
L
L
A
G
L
L
K
K
D
P
K
Q
R
L
G
G
G
-
P
-
S
D
A
K
E
V
M
E
H
R
F
F
L
S
I
N
---
W
Q
D
V
V
Q
K
K
L
L
P
P
F
K
P
Q
V
T
S
E
V
D
T
R
Y
F
D
D
E
F
T
A
Q
S
I
T
I
T
P
P
D
-------------
Q
R
T
H
F
P
Q
F
D
Y
S
A
S
I
R
-
28
PsiBlast_CBE
82.93
81%
-106
- C1 -
2JDR
1
AKT2_HUMAN
A:
[8-340]
-----------------------------------------------------------------------------------------------------------------------------------------------------
T
M
N
D
F
D
Y
L
K
L
L
G
K
G
-
T
F
G
K
V
I
L
V
R
E
---
K
A
---
T
-
G
----
R
Y
Y
A
M
K
I
L
R
K
E
V
I
I
--
A
-
K
D
---
E
V
A
H
T
V
T
E
S
R
V
-
L
-
Q
--
N
-
T
-
R
H
P
F
L
T
A
L
K
Y
A
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
-
E
--
R
V
F
T
E
E
R
A
R
F
Y
G
A
E
I
V
S
A
L
E
Y
L
H
S
-
R
D
--
V
V
Y
R
D
I
K
L
E
N
L
M
L
D
-
K
D
G
----
H
I
K
I
T
D
F
G
L
C
K
E
G
I
S
D
G
A
T
M
K
--
T
-
F
C
G
T
P
E
Y
L
A
P
E
V
L
E
D
-----
N
---
D
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
-
R
L
P
F
Y
--
N
---
Q
----
D
H
E
R
L
F
E
L
I
L
M
E
------
E
--
I
R
F
P
----
R
T
L
S
P
E
A
K
S
L
L
A
G
L
L
K
K
D
P
K
Q
R
L
G
G
G
-
P
-
S
D
A
K
E
V
M
E
H
R
F
F
L
S
I
N
---
W
Q
D
V
V
Q
K
K
L
L
P
P
F
K
P
Q
V
T
S
E
V
D
T
R
Y
F
D
D
E
F
T
A
Q
S
I
T
-------------------
Q
E
M
F
E
D
F
D
Y
I
A
D
W
--
25
PsiBlast_CBE
82.91
81%
-112
- C1 -
2XH5
1
AKT2_HUMAN
A:
[8-340]
-----------------------------------------------------------------------------------------------------------------------------------------------------
T
M
N
D
F
D
Y
L
K
L
L
G
K
G
-
T
F
G
K
V
I
L
V
R
E
---
K
A
---
T
-
G
----
R
Y
Y
A
M
K
I
L
R
K
E
V
I
I
--
A
-
K
D
---
E
V
A
H
T
V
T
E
S
R
V
-
L
-
Q
--
N
-
T
-
R
H
P
F
L
T
A
L
K
Y
A
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
-
E
--
R
V
F
T
E
E
R
A
R
F
Y
G
A
E
I
V
S
A
L
E
Y
L
H
S
-
R
D
--
V
V
Y
R
D
I
K
L
E
N
L
M
L
D
-
K
D
G
----
H
I
K
I
T
D
F
G
L
C
K
E
G
I
S
D
G
A
T
M
K
--
T
-
F
C
G
T
P
E
Y
L
A
P
E
V
L
E
D
-----
N
---
D
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
-
R
L
P
F
Y
--
N
---
Q
----
D
H
E
R
L
F
E
L
I
L
M
E
------
E
--
I
R
F
P
----
R
T
L
S
P
E
A
K
S
L
L
A
G
L
L
K
K
D
P
K
Q
R
L
G
G
G
-
P
-
S
D
A
K
E
V
M
E
H
R
F
F
L
S
I
N
---
W
Q
D
V
V
Q
K
K
L
L
P
P
F
K
P
Q
V
T
S
E
V
D
T
R
Y
F
D
D
E
F
T
A
Q
S
I
T
-------------------
Q
E
M
F
E
D
F
D
Y
I
A
D
W
--
23
PsiBlast_CBE
82.83
85%
-106
- C1 -
3OCB
1
AKT1_HUMAN
B:
[5-338]
---------------------------------------------------------------------------------------------------------------------------------------------------
R
V
T
M
N
E
F
E
Y
L
K
L
L
G
K
G
-
T
F
G
K
V
I
L
V
K
E
---
K
A
---
T
-
G
----
R
Y
Y
A
M
K
I
L
K
K
E
V
I
V
--
A
-
K
D
---
E
V
A
H
T
L
T
E
N
R
V
-
L
-
Q
--
N
-
S
-
R
H
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
-
E
--
R
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
-
E
K
N-
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
-
K
D
G
----
H
I
K
I
T
D
F
G
L
C
K
E
G
I
K
D
G
A
T
M
K
--
T
-
F
C
G
T
P
E
Y
L
A
P
E
V
L
E
D
-----
N
---
D
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
-
R
L
P
F
Y
--
N
---
Q
----
D
H
E
K
L
F
E
L
I
L
M
E
------
E
--
I
R
F
P
----
R
T
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
R
L
G
G
G
-
S
-
E
D
A
K
E
I
M
Q
H
R
F
F
A
G
I
V
---
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
P
Q
V
T
S
E
T
D
T
R
Y
F
D
E
E
F
T
A
Q
M
I
T
I
T
-----------------
R
P
H
F
P
Q
F
D
Y
S
A
S
S
--
9
PsiBlast_PDB
82.74
85%
-103
- C1 -
4EKL
1
AKT1_HUMAN
A:
[5-338]
---------------------------------------------------------------------------------------------------------------------------------------------------
R
V
T
M
N
E
F
E
Y
L
K
L
L
G
K
G
-
T
F
G
K
V
I
L
V
K
E
---
K
A
---
T
-
G
----
R
Y
Y
A
M
K
I
L
K
K
E
V
I
V
--
A
-
K
D
---
E
V
A
H
T
L
T
E
N
R
V
-
L
-
Q
--
N
-
S
-
R
H
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
-
E
--
R
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
-
E
K
N-
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
-
K
D
G
----
H
I
K
I
T
D
F
G
L
C
K
E
G
I
K
D
G
A
T
M
K
--
T
-
F
C
G
T
P
E
Y
L
A
P
E
V
L
E
D
-----
N
---
D
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
-
R
L
P
F
Y
--
N
---
Q
----
D
H
E
K
L
F
E
L
I
L
M
E
------
E
--
I
R
F
P
----
R
T
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
R
L
G
G
G
-
S
-
E
D
A
K
E
I
M
Q
H
R
F
F
A
G
I
V
---
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
P
Q
V
T
S
E
T
D
T
R
Y
F
D
E
E
F
T
A
Q
M
I
T
I
T
P
-------
S
M
E
C
V
D
S
E
R
R
P
H
F
P
Q
F
D
Y
S
A
S
S
--
7
PsiBlast_PDB
82.74
85%
-106
- C1 -
3QKM
1
AKT1_HUMAN
A:
[5-338]
---------------------------------------------------------------------------------------------------------------------------------------------------
R
V
T
M
N
E
F
E
Y
L
K
L
L
G
K
G
-
T
F
G
K
V
I
L
V
K
E
---
K
A
---
T
-
G
----
R
Y
Y
A
M
K
I
L
K
K
E
V
I
V
--
A
-
K
D
---
E
V
A
H
T
L
T
E
N
R
V
-
L
-
Q
--
N
-
S
-
R
H
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
-
E
--
R
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
-
E
K
N-
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
-
K
D
G
----
H
I
K
I
T
D
F
G
L
C
K
E
G
I
K
D
G
A
T
M
K
--
T
-
F
C
G
T
P
E
Y
L
A
P
E
V
L
E
D
-----
N
---
D
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
-
R
L
P
F
Y
--
N
---
Q
----
D
H
E
K
L
F
E
L
I
L
M
E
------
E
--
I
R
F
P
----
R
T
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
R
L
G
G
G
-
S
-
E
D
A
K
E
I
M
Q
H
R
F
F
A
G
I
V
---
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
P
Q
V
T
S
E
T
D
T
R
Y
F
D
E
E
F
T
A
Q
M
I
T
I
T
P
-------
S
M
E
C
V
D
S
E
R
R
P
H
F
P
Q
F
D
Y
S
A
S
S
--
11
PsiBlast_PDB
82.40
85%
-107
- C1 -
3CQW
1
AKT1_HUMAN
A:
[6-339]
---------------------------------------------------------------------------------------------------------------------------------------------------
R
V
T
M
N
E
F
E
Y
L
K
L
L
G
K
G
-
T
F
G
K
V
I
L
V
K
E
---
K
A
---
T
-
G
----
R
Y
Y
A
M
K
I
L
K
K
E
V
I
V
--
A
-
K
D
---
E
V
A
H
T
L
T
E
N
R
V
-
L
-
Q
--
N
-
S
-
R
H
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
-
E
--
R
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
-
E
K
N-
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
-
K
D
G
----
H
I
K
I
T
D
F
G
L
C
K
E
G
I
K
D
G
A
T
M
K
--
T
-
F
C
G
T
P
E
Y
L
A
P
E
V
L
E
D
-----
N
---
D
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
-
R
L
P
F
Y
--
N
---
Q
----
D
H
E
K
L
F
E
L
I
L
M
E
------
E
--
I
R
F
P
----
R
T
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
R
L
G
G
G
-
S
-
E
D
A
K
E
I
M
Q
H
R
F
F
A
G
I
V
---
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
P
Q
V
T
S
E
T
D
T
R
Y
F
D
E
E
F
T
A
Q
M
I
------------------
E
R
R
P
H
F
P
Q
F
D
Y
S
A
S
S
--
5
PsiBlast_PDB
82.27
85%
-102
- C1 -
3QKK
1
AKT1_HUMAN
A:
[5-338]
---------------------------------------------------------------------------------------------------------------------------------------------------
R
V
T
M
N
E
F
E
Y
L
K
L
L
G
K
G
-
T
F
G
K
V
I
L
V
K
E
---
K
A
---
T
-
G
----
R
Y
Y
A
M
K
I
L
K
K
E
V
I
V
--
A
-
K
D
---
E
V
A
H
T
L
T
E
N
R
V
-
L
-
Q
--
N
-
S
-
R
H
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
-
E
--
R
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
-
E
K
N-
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
-
K
D
G
----
H
I
K
I
T
D
F
G
L
C
K
E
G
I
K
D
G
A
T
M
K
--
T
-
F
C
G
T
P
E
Y
L
A
P
E
V
L
E
D
-----
N
---
D
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
-
R
L
P
F
Y
--
N
---
Q
----
D
H
E
K
L
F
E
L
I
L
M
E
------
E
--
I
R
F
P
----
R
T
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
R
L
G
G
G
-
S
-
E
D
A
K
E
I
M
Q
H
R
F
F
A
G
I
V
---
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
P
Q
V
T
S
E
T
D
T
R
Y
F
D
E
E
F
T
A
Q
M
I
T
I
----------
M
E
C
V
D
S
E
R
R
P
H
F
P
Q
F
D
Y
S
A
S
S
--
87
HHSearch
66.30
45%
-106
- C1 -
1XJD
1
A:
[16-335]
------------------------------------------------------------------------------------------------------------------------------------------------------
I
E
D
F
I
L
H
K
M
L
G
K
G
-
S
F
G
K
V
F
L
A
E
F
---
K
K
---
T
-
N
----
Q
F
F
A
I
K
A
L
K
K
D
V
V
L
--
M
-
D
D
---
D
V
E
C
T
M
V
E
K
R
V
-
L
-
S
--
L
A
W
-
E
H
P
F
L
T
H
M
F
C
T
F
Q
T
K
E
N
L
F
F
V
M
E
Y
L
N
G
G
D
L
M
Y
H
I
Q
S
-
C
--
H
K
F
D
L
S
R
A
T
F
Y
A
A
E
I
I
L
G
L
Q
F
L
H
S
-
K
G
--
I
V
Y
R
D
L
K
L
D
N
I
L
L
D
-
K
D
G
----
H
I
K
I
A
D
F
G
M
C
K
E
N
M
L
G
D
A
K
T
N
--
T
-
F
C
G
T
P
D
Y
I
A
P
E
I
L
L
G
-----
Q
---
K
Y
N
H
S
V
D
W
W
S
F
G
V
L
L
Y
E
M
L
I
G
-
Q
S
P
F
H
--
G
---
Q
----
D
E
E
E
L
F
H
S
I
R
M
D
------
N
--
P
F
Y
P
----
R
W
L
E
K
E
A
K
D
L
L
V
K
L
F
V
R
E
P
E
K
R
L
G
V
------
R
G
D
I
R
Q
H
P
L
F
R
E
I
N
---
W
E
E
L
E
R
K
E
I
D
P
--------------------------------------------
Q
N
M
F
R
N
F
S
F
------
43
PsiBlast_CBE
66.18
47%
-96
- C1 -
4Q9Z
1
KPCT_HUMAN
A:
[4-298]
------------------------------------------------------------------------------------------------------------------------------------------------------
I
E
D
F
E
L
H
K
M
L
G
K
G
-
S
F
G
K
V
F
L
A
E
F
---
K
K
---
T
-
N
----
Q
F
F
A
I
K
A
L
K
K
D
V
V
L
--
M
-
D
D
---
D
V
E
C
T
M
V
E
K
R
V
-
L
-
S
--
L
-
A
W
E
H
P
F
L
T
H
M
F
C
T
F
Q
T
K
E
N
L
F
F
V
M
E
Y
L
N
G
G
D
L
M
Y
H
I
Q
S
-
C
--
H
K
F
D
L
S
R
A
T
F
Y
A
A
E
I
I
L
G
L
Q
F
L
H
S
-
K
G
--
I
V
Y
R
D
L
K
L
D
N
I
L
L
D
-
K
D
G
----
H
I
K
I
A
D
F
G
M
C
K
E
N
M
L
G
D
A
K
T
N
--
E
-
F
C
G
T
P
D
Y
I
A
P
E
I
L
L
G
-----
Q
---
K
Y
N
H
S
V
D
W
W
S
F
G
V
L
L
Y
E
M
L
I
G
-
Q
S
P
F
H
--
G
---
Q
----
D
E
E
E
L
F
H
S
I
R
M
D
------
N
--
P
F
Y
P
----
R
W
L
E
K
E
A
K
D
L
L
V
K
L
F
V
R
E
P
E
K
R
L
G
V
R
-
G
-
D
----
I
R
Q
H
P
L
F
R
E
I
N
---
W
E
E
L
E
R
K
E
I
D
P
P
F
R
P
K
V
K
S
P
F
D
C
S
N
F
D
K
E
F
L
N
E
K
P
R
L
S
F
A
D
R
A
L
I
N
S
M
D
Q
N
M
F
R
N
F
S
F
M
N
P
G
M
E
R
L
I
S
H
-
89
HHSearch
66.02
46%
-91
- C1 -
4DC2
1
KPCI_MOUSE
A:
[49-387]
----------------------------------------------------------------------------------------------------------------------------------------------------
L
G
L
Q
D
F
D
L
L
R
V
I
G
R
G
-
S
Y
A
K
V
L
L
V
R
L
---
K
K
---
T
-
D
----
R
I
Y
A
M
R
V
V
K
K
E
L
V
N
----------
I
D
W
V
Q
T
E
K
H
V
-
F
-
E
--
Q
-
A
S
N
H
P
F
L
V
G
L
H
S
C
F
Q
T
E
S
R
L
F
F
V
I
E
Y
V
N
G
G
D
L
M
F
H
M
Q
R
-
Q
--
R
K
L
P
E
E
H
A
R
F
Y
S
A
E
I
S
L
A
L
N
Y
L
H
E
-
R
G
--
I
I
Y
R
D
L
K
L
D
N
V
L
L
D
-
S
E
G
----
H
I
K
L
T
D
Y
G
M
C
K
E
G
L
R
P
G
D
T
T
S
--
T
-
F
C
G
T
P
N
Y
I
A
P
E
I
L
R
G
-----
E
---
D
Y
G
F
S
V
D
W
W
A
L
G
V
L
M
F
E
M
M
A
G
-
R
S
P
F
D
--
I
VGS
N
----
T
E
D
Y
L
F
Q
V
I
L
E
K
------
Q
--
I
R
I
P
----
R
S
L
S
V
K
A
A
S
V
L
K
S
F
L
N
K
D
P
K
E
R
L
G
C
H
P
Q
-
T
G
F
A
D
I
Q
G
H
P
F
F
R
N
V
D
---
W
D
M
M
E
Q
K
Q
V
V
P
P
F
K
P
N
I
S
G
E
F
G
L
D
N
F
D
S
Q
F
T
N
E
P
V
Q
L
T
P
D
D
D
D
I
V
R
---
K
I
D
---
Q
S
E
F
E
G
F
E
Y
I
N
P
---
42
PsiBlast_CBE
65.64
47%
-100
- C1 -
4RA5
3
KPCT_HUMAN
A:
[4-298]
------------------------------------------------------------------------------------------------------------------------------------------------------
I
E
D
F
E
L
H
K
M
L
G
K
G
-
S
F
G
K
V
F
L
A
E
F
---
K
K
---
T
-
N
----
Q
F
F
A
I
K
A
L
K
K
D
V
V
L
--
M
-
D
D
---
D
V
E
C
T
M
V
E
K
R
V
-
L
-
S
--
L
-
A
W
E
H
P
F
L
T
H
M
F
C
T
F
Q
T
K
E
N
L
F
F
V
M
E
Y
L
N
G
G
D
L
M
Y
H
I
Q
S
-
C
--
H
K
F
D
L
S
R
A
T
F
Y
A
A
E
I
I
L
G
L
Q
F
L
H
S
-
K
G
--
I
V
Y
R
D
L
K
L
D
N
I
L
L
D
-
K
D
G
----
H
I
K
I
A
D
F
G
M
C
K
E
N
M
L
G
D
A
K
T
N
--
E
-
F
C
G
T
P
D
Y
I
A
P
E
I
L
L
G
-----
Q
---
K
Y
N
H
S
V
D
W
W
S
F
G
V
L
L
Y
E
M
L
I
G
-
Q
S
P
F
H
--
G
---
Q
----
D
E
E
E
L
F
H
S
I
R
M
D
------
N
--
P
F
Y
P
----
R
W
L
E
K
E
A
K
D
L
L
V
K
L
F
V
R
E
P
E
K
R
L
G
V
R
-
G
-
D
----
I
R
Q
H
P
L
F
R
E
I
N
---
W
E
E
L
E
R
K
E
I
D
P
P
F
R
P
K
V
K
S
P
F
D
C
S
N
F
D
K
E
F
L
N
E
K
P
R
L
S
F
A
D
R
A
L
I
N
S
M
D
Q
N
M
F
R
N
F
S
F
M
N
P
G
M
E
R
L
I
S
H
-
90
HHSearch
65.06
37%
-88
- C1 -
4AW2
3
MRCKA_RAT
A:
[70-406]
---------------------------------------------------------------------------------------------------------------------------------------------------
R
L
H
R
E
D
F
E
I
L
K
V
I
G
R
G
-
A
F
G
E
V
A
V
V
K
L
---
K
N
---
A
-
D
----
K
V
F
A
M
K
I
L
N
K
W
E
M
L
--
K
-
R
A
---
E
T
A
C
F
R
E
E
R
D
V
-
L
-
V
--
N
-
G
-
D
S
K
W
I
T
T
L
H
Y
A
F
Q
D
D
N
N
L
Y
L
V
M
D
Y
Y
V
G
G
D
L
L
T
L
L
S
K
F
E
--
D
R
L
P
E
E
M
A
R
F
Y
L
A
E
M
V
I
A
I
D
S
V
H
Q
-
L
H
--
Y
V
H
R
D
I
K
P
D
N
I
L
M
D
-
M
N
G
----
H
I
R
L
A
D
F
G
S
C
L
K
L
M
E
D
G
T
V
Q
S
--
S
V
A
V
G
T
P
D
Y
I
S
P
E
I
L
Q
A
M
E
GGK
G
---
R
Y
G
P
E
C
D
W
W
S
L
G
V
C
M
Y
E
M
L
Y
G
-
E
T
P
F
Y
--
A
---
E
----
S
L
V
E
T
Y
G
K
I
M
N
H
------
K
ER
F
Q
F
P
TQV-
T
D
V
S
E
N
A
K
D
L
I
R
R
L
I
C
-
S
R
E
H
R
L
G
---
Q
-
N
G
I
E
D
F
K
K
H
P
F
F
S
G
I
D
---
W
D
N
I
--
R
N
C
E
A
P
Y
I
P
E
V
S
S
P
T
D
T
S
N
F
D
V
D
-----------------------
S
G
H
H
L
P
F
V
G
F
T
Y
T
S
S
C
V
L
50
PsiBlast_CBE
64.55
44%
-97
- C1 -
4NW5
1
KS6A3_HUMAN
A:
[15-322]
--------------------------------------------------------------------------------------------------------------------------------------
A
I
T
H
H
V
K
E
G
H
--
E
K
A
D
P
S
Q
F
E
L
L
K
V
L
G
Q
G
-
S
F
G
K
V
F
L
V
K
----
K
I
---
S
-
G
SDAR
Q
L
Y
A
M
K
V
L
K
K
A
T
L
K
--
V
-
R
D
---
R
V
-
R
T
K
M
E
R
D
I
-
L
-
V
--
E
-
V
-
N
H
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
-
E
--
V
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
S
-
L
G
--
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
-
E
E
G
----
H
I
K
L
T
D
F
G
L
S
K
E
S
I
D
H
E
K
K
A
Y
--
S
-
F
C
G
T
V
E
Y
M
A
P
E
V
V
N
R
-----
R
---
G
H
T
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
-
T
L
P
F
Q
--
G
---
K
----
D
R
K
E
T
M
T
M
I
L
K
A
------
K
--
L
G
M
P
----
Q
F
L
S
P
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
R
L
G
A
G
-
P
-
D
G
V
E
E
I
K
R
H
S
F
F
S
T
I
D
---
W
N
K
L
Y
R
R
E
I
H
P
P
F
K
P
-------
T
F
Y
F
D
P
------------------------------------------
92
HHSearch
64.23
43%
-92
- C1 -
1RDQ
3
KAPCA_MOUSE
E:
[37-338]
---------------------------------------------------------------------------------------------------------------------------------------------------
T
A
Q
L
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
S
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
-
L
K
---
Q
I
E
H
T
L
N
E
K
R
I
-
L
-
Q
--
A
-
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
-
I
--
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
--
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
----
Y
I
Q
V
T
D
F
G
F
A
K
R
V
K
---
G
R
T
W
--
T
-
L
C
G
T
P
E
A
L
A
P
E
I
I
L
S
-----
K
---
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
F
--
A
---
D
----
Q
P
I
Q
I
Y
E
K
I
V
S
G
------
K
--
V
R
F
P
----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
L
-
K
-
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
-
Y
E
E
E
E
I
R
V
S
I
N
E
K
C
G
K
E
F
T
E
F
--------------------
63
PsiBlast_CBE
63.84
41%
-90
- C1 -
2UZT
1
KAPCA_BOVIN
A:
[11-328]
-----------------------------------------------------------------------------------------------------------------------------
D
F
L
K
K
W
E
N
P
A
Q
N
T
A
----
H
------
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
M
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
-
L
K
---
Q
I
E
H
T
L
N
E
K
R
I
-
L
-
Q
--
A
-
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
--
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
--
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
----
Y
I
Q
V
T
D
F
G
F
A
K
R
V
---
K
G
R
T
W
--
T
-
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
-----
K
---
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
F
--
A
---
D
----
Q
P
I
Q
I
Y
E
K
I
V
S
G
------
K
--
V
R
F
P
----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
L
-
K
-
D
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-
D
Y
E
E
E
E
I
R
V
S
I
N
E
K
C
G
K
E
F
S
E
F
--------------------
49
PsiBlast_CBE
63.62
44%
-94
- C1 -
4NW6
1
KS6A3_HUMAN
A:
[15-322]
--------------------------------------------------------------------------------------------------------------------------------------
A
I
T
H
H
V
K
E
G
H
--
E
K
A
D
P
S
Q
F
E
L
L
K
V
L
G
Q
G
-
S
F
G
K
V
F
L
V
K
----
K
I
---
S
-
G
SDAR
Q
L
Y
A
M
K
V
L
K
K
A
T
L
K
--
V
-
R
D
---
R
V
-
R
T
K
M
E
R
D
I
-
L
-
V
--
E
-
V
-
N
H
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
-
E
--
V
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
S
-
L
G
--
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
-
E
E
G
----
H
I
K
L
T
D
F
G
L
S
K
E
S
I
D
H
E
K
K
A
Y
--
S
-
F
C
G
T
V
E
Y
M
A
P
E
V
V
N
R
-----
R
---
G
H
T
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
-
T
L
P
F
Q
--
G
---
K
----
D
R
K
E
T
M
T
M
I
L
K
A
------
K
--
L
G
M
P
----
Q
F
L
S
P
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
R
L
G
A
G
-
P
-
D
G
V
E
E
I
K
R
H
S
F
F
S
T
I
D
---
W
N
K
L
Y
R
R
E
I
H
P
P
F
K
P
-------
T
F
Y
F
D
P
------------------------------------------
35
PsiBlast_CBE
63.10
45%
-103
- C1 -
4L42
1
KS6B1_HUMAN
A:
[20-344]
---------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
L
L
R
V
L
G
K
G
-
G
Y
G
K
V
F
Q
V
R
K
VTG
A
N
---
T
-
G
----
K
I
F
A
M
K
V
L
K
K
A
M
I
V
RN
A
-
K
D
----
T
A
H
T
K
A
E
R
N
I
-
L
-
E
--
E
-
V
-
K
H
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
-
E
--
G
I
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
-
K
G
--
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
-
H
Q
G
----
H
V
K
L
T
D
F
G
L
C
K
E
S
I
H
D
G
T
V
T
H
--
T
-
F
C
G
T
I
E
Y
M
A
P
E
I
L
M
R
-----
S
---
G
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
-
A
P
P
F
T
--
G
---
E
----
N
R
K
K
T
I
D
K
I
L
K
C
------
K
--
L
N
L
P
----
P
Y
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
R
L
G
A
G
-
P
-
G
D
A
G
E
V
Q
A
H
P
F
F
R
H
I
N
---
W
E
E
L
L
A
R
K
V
E
P
P
F
K
------------------------------------------
E
M
F
R
D
F
E
Y
I
A
D
W
--
60
PsiBlast_CBE
62.96
41%
-86
- C1 -
2UZW
1
KAPCA_BOVIN
E:
[11-328]
-----------------------------------------------------------------------------------------------------------------------------
D
F
L
K
K
W
E
N
P
A
Q
N
T
A
----
H
------
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
M
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
-
L
K
---
Q
I
E
H
T
L
N
E
K
R
I
-
L
-
Q
--
A
-
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
--
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
--
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
----
Y
I
Q
V
T
D
F
G
F
A
K
R
V
---
K
G
R
T
W
--
T
-
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
-----
K
---
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
F
--
A
---
D
----
Q
P
I
Q
I
Y
E
K
I
V
S
G
------
K
--
V
R
F
P
----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
L
-
K
-
D
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-
D
Y
E
E
E
E
I
R
V
S
I
N
E
K
C
G
K
E
F
S
E
F
--------------------
83
HHSearch
62.81
45%
-94
- C1 -
3TXO
1
KPCL_HUMAN
A:
[23-349]
-------------------------------------------------------------------------------------------------------------------------------------------------------
D
N
F
E
F
I
R
V
L
G
K
G
-
S
F
G
K
V
M
L
A
R
V
---
K
E
---
T
-
G
----
D
L
Y
A
V
K
V
L
K
K
D
V
I
L
--
Q
-
D
D
---
D
V
E
C
T
M
T
E
K
R
I
-
L
-
S
--
L
-
A
R
N
H
P
F
L
T
Q
L
F
C
C
F
Q
T
P
D
R
L
F
F
V
M
E
F
V
N
G
G
D
L
M
F
H
I
Q
K
-
S
--
R
R
F
D
E
A
R
A
R
F
Y
A
A
E
I
I
S
A
L
M
F
L
H
D
-
K
G
--
I
I
Y
R
D
L
K
L
D
N
V
L
L
D
-
H
E
G
----
H
C
K
L
A
D
F
G
M
C
K
E
G
I
C
------------
G
T
P
D
Y
I
A
P
E
I
L
Q
E
-----
M
---
L
Y
G
P
A
V
D
W
W
A
M
G
V
L
L
Y
E
M
L
C
G
-
H
A
P
F
E
--
A
---
E
----
N
E
D
D
L
F
E
A
I
L
N
D
------
E
--
V
V
Y
P
----
T
W
L
H
E
D
A
T
G
I
L
K
S
F
M
T
K
N
P
T
M
R
L
G
S
L
-
T
Q
G
G
E
H
A
I
L
R
H
P
F
F
K
E
I
D
---
W
A
Q
L
N
H
R
Q
I
E
P
P
F
R
P
R
I
K
S
R
E
D
V
S
N
F
D
P
D
F
I
K
E
E
P
V
L
T
P
I
D
E
G
H
L
---
P
M
I
---
N
Q
D
E
F
R
N
F
E
Y
V
S
P
---
68
PsiBlast_CBE
62.61
39%
-82
- C1 -
2F7E
1
KAPCA_BOVIN
E:
[16-343]
-------------------------------------------------------------------------------------------------------------------
V
K
E
F
L
A
K
A
K
E
D
F
L
K
K
W
E
N
P
A
Q
N
T
A
----
H
------
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
M
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
-
L
K
---
Q
I
E
H
T
L
N
E
K
R
I
-
L
-
Q
--
A
-
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
--
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
--
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
----
Y
I
Q
V
T
D
F
G
F
A
K
R
---
V
K
G
R
T
W
--
T
-
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
-----
K
---
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
F
--
A
---
D
----
Q
P
I
Q
I
Y
E
K
I
V
S
G
------
K
--
V
R
F
P
----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
L
-
K
-
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-
D
Y
E
E
E
E
I
R
V
S
I
N
E
K
C
G
K
E
F
S
E
F
--------------------
40
PsiBlast_CBE
62.51
44%
-107
- C1 -
5D9K
2
?
A:
[26-323]
---------------------------------------------------------------------------------------------------------------------------------------------------
K
A
D
P
S
Q
F
E
L
L
K
V
L
G
Q
G
-
S
F
G
K
V
F
L
V
K
----
K
I
---
S
-
G
SDAR
Q
L
Y
A
M
K
V
L
K
K
A
T
L
K
--
V
-
R
D
---
R
V
-
R
T
K
M
E
R
D
I
-
L
-
V
--
E
-
V
-
N
H
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
-
E
--
V
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
S
-
L
G
--
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
-
E
E
G
----
H
I
K
L
T
D
F
G
L
S
K
---------------
C
G
T
V
E
Y
M
A
P
E
V
V
N
R
-----
R
---
G
H
T
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
-
T
L
P
F
Q
--
G
---
K
----
D
R
K
E
T
M
T
M
I
L
K
A
------
K
--
L
G
M
P
----
Q
F
L
S
P
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
R
L
G
A
G
-
P
-
D
G
V
E
E
I
K
R
H
S
F
F
S
T
I
D
---
W
N
K
L
Y
R
R
E
I
H
P
P
F
K
P
A
T
------
F
Y
F
D
P
------------------------------------------
39
PsiBlast_CBE
62.33
44%
-104
- C1 -
5D9K
2
?
B:
[26-323]
---------------------------------------------------------------------------------------------------------------------------------------------------
K
A
D
P
S
Q
F
E
L
L
K
V
L
G
Q
G
-
S
F
G
K
V
F
L
V
K
----
K
I
---
S
-
G
SDAR
Q
L
Y
A
M
K
V
L
K
K
A
T
L
K
--
V
-
R
D
---
R
V
-
R
T
K
M
E
R
D
I
-
L
-
V
--
E
-
V
-
N
H
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
-
E
--
V
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
S
-
L
G
--
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
-
E
E
G
----
H
I
K
L
T
D
F
G
L
S
K
E
--------------
C
G
T
V
E
Y
M
A
P
E
V
V
N
R
-----
R
---
G
H
T
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
-
T
L
P
F
Q
--
G
---
K
----
D
R
K
E
T
M
T
M
I
L
K
A
------
K
--
L
G
M
P
----
Q
F
L
S
P
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
R
L
G
A
G
-
P
-
D
G
V
E
E
I
K
R
H
S
F
F
S
T
I
D
---
W
N
K
L
Y
R
R
E
I
H
P
P
F
K
P
-------
T
F
Y
F
D
P
------------------------------------------
94
HHSearch
62.04
46%
-99
- C1 -
3WF7
2
KS6B1_HUMAN
A:
[13-304]
-----------------------------------------------------------------------------------------------------------------------------------------------
P
--
E
K
I
R
P
E
C
F
E
L
L
R
V
L
G
K
G
-
G
Y
G
K
V
F
Q
V
R
K
VTG
A
N
---
T
-
G
----
K
I
F
A
M
K
V
L
K
K
A
M
I
V
--
R
N
A
K
---
D
T
A
H
T
K
A
E
R
N
I
-
L
-
E
--
E
-
V
-
K
H
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
-
E
--
G
I
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
-
K
G
--
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
-
H
Q
G
----
H
V
K
L
T
D
F
G
L
C
K
E
S
I
H
D
---
T
H
--
T
-
F
C
G
T
I
E
Y
M
A
P
E
I
L
M
R
-----
S
---
G
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
-
A
P
P
F
T
--
G
---
E
----
N
R
K
K
T
I
D
K
I
L
K
C
------
K
--
L
N
L
P
----
P
Y
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
R
L
G
A
G
-
P
-
G
D
A
G
E
V
Q
A
H
P
F
F
R
H
I
N
---
W
E
E
L
L
A
R
K
V
E
P
P
F
K
P
L
L
Q
----------------------------------------------------
66
PsiBlast_CBE
61.88
39%
-86
- C1 -
2F7Z
1
KAPCA_BOVIN
E:
[16-343]
-------------------------------------------------------------------------------------------------------------------
V
K
E
F
L
A
K
A
K
E
D
F
L
K
K
W
E
N
P
A
Q
N
T
A
----
H
------
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
M
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
-
L
K
---
Q
I
E
H
T
L
N
E
K
R
I
-
L
-
Q
--
A
-
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
--
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
--
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
----
Y
I
Q
V
T
D
F
G
F
A
K
R
---
V
K
G
R
T
W
--
T
-
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
-----
K
---
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
F
--
A
---
D
----
Q
P
I
Q
I
Y
E
K
I
V
S
G
------
K
--
V
R
F
P
----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
L
-
K
-
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-
D
Y
E
E
E
E
I
R
V
S
I
N
E
K
C
G
K
E
F
S
E
F
--------------------
64
PsiBlast_CBE
61.87
39%
-82
- C1 -
2OJF
1
KAPCA_BOVIN
E:
[16-343]
-------------------------------------------------------------------------------------------------------------------
V
K
E
F
L
A
K
A
K
E
D
F
L
K
K
W
E
N
P
A
Q
N
T
A
----
H
------
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
M
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
-
L
K
---
Q
I
E
H
T
L
N
E
K
R
I
-
L
-
Q
--
A
-
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
--
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
--
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
----
Y
I
Q
V
T
D
F
G
F
A
K
R
---
V
K
G
R
T
W
--
T
-
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
-----
K
---
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
F
--
A
---
D
----
Q
P
I
Q
I
Y
E
K
I
V
S
G
------
K
--
V
R
F
P
----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
L
-
K
-
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-
D
Y
E
E
E
E
I
R
V
S
I
N
E
K
C
G
K
E
F
S
E
F
--------------------
62
PsiBlast_CBE
61.76
41%
-84
- C1 -
2UZU
1
KAPCA_BOVIN
E:
[11-328]
-----------------------------------------------------------------------------------------------------------------------------
D
F
L
K
K
W
E
N
P
A
Q
N
T
A
----
H
------
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
M
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
-
L
K
---
Q
I
E
H
T
L
N
E
K
R
I
-
L
-
Q
--
A
-
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
--
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
--
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
----
Y
I
Q
V
T
D
F
G
F
A
K
R
V
---
K
G
R
T
W
--
T
-
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
-----
K
---
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
F
--
A
---
D
----
Q
P
I
Q
I
Y
E
K
I
V
S
G
------
K
--
V
R
F
P
----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
L
-
K
-
D
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-
D
Y
E
E
E
E
I
R
V
S
I
N
E
K
C
G
K
E
F
S
E
F
--------------------
51
PsiBlast_CBE
61.46
44%
-94
- C1 -
4NUS
1
KS6A3_HUMAN
A:
[17-322]
----------------------------------------------------------------------------------------------------------------------------------------
T
H
H
V
K
E
G
H
--
E
K
A
D
P
S
Q
F
E
L
L
K
V
L
G
Q
G
-
S
F
G
K
V
F
L
V
K
----
K
I
---
S
-
G
SDAR
Q
L
Y
A
M
K
V
L
K
K
A
T
L
K
--
V
-
R
D
---
R
V
-
R
T
K
M
E
R
D
I
-
L
-
V
--
E
-
V
-
N
H
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
-
E
--
V
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
S
-
L
G
--
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
-
E
E
G
----
H
I
K
L
T
D
F
G
L
S
K
E
S
I
D
H
E
K
K
A
Y
--
S
-
F
C
G
T
V
E
Y
M
A
P
E
V
V
N
R
-----
R
---
G
H
T
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
-
T
L
P
F
Q
--
G
---
K
----
D
R
K
E
T
M
T
M
I
L
K
A
------
K
--
L
G
M
P
----
Q
F
L
S
P
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
R
L
G
A
G
-
P
-
D
G
V
E
E
I
K
R
H
S
F
F
S
T
I
D
---
W
N
K
L
Y
R
R
E
I
H
P
P
F
K
P
A
T
------
F
Y
F
D
P
------------------------------------------
82
HHSearch
61.45
50%
-112
- C1 -
2R5T
1
SGK1_HUMAN
A:
[32-320]
-----------------------------------------------------------------------------------------------------------------------------------------------
N
--
P
H
A
K
P
S
D
F
H
F
L
K
V
I
G
K
G
-
S
F
G
K
V
L
L
A
R
H
---
K
A
---
E
-
E
----
V
F
Y
A
V
K
V
L
Q
K
K
A
I
L
-------------------
V
L
L
-
K
--
N
-
V
-
K
H
P
F
L
V
G
L
H
F
S
F
Q
T
A
D
K
L
Y
F
V
L
D
Y
I
N
G
G
E
L
F
Y
H
L
Q
R
-
E
--
R
C
F
L
E
P
R
A
R
F
Y
A
A
E
I
A
S
A
L
G
Y
L
H
S
-
L
N
--
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
-
S
Q
G
----
H
I
V
L
T
D
F
G
L
C
K
E
N
I
E
H
N
S
T
T
S
--
T
-
F
C
G
T
P
E
Y
L
A
P
E
V
L
H
K
-----
Q
---
P
Y
D
R
T
V
D
W
W
C
L
G
A
V
L
Y
E
M
L
Y
G
-
L
P
P
F
Y
--
S
---
R
----
N
T
A
E
M
Y
D
N
I
L
N
K
------
P
--
L
Q
L
K
----
P
N
I
T
N
S
A
R
H
L
L
E
G
L
L
Q
K
D
R
T
K
R
L
G
A
--
K
-
D
D
F
M
E
I
K
S
H
V
F
F
S
L
I
N
---
W
D
D
L
I
N
K
K
I
T
P
P
F
N
P
N
V
S
G
---------------------------------------------------
47
PsiBlast_CBE
60.97
45%
-105
- C1 -
2Z7Q
1
KS6A1_HUMAN
A:
[24-308]
---------------------------------------------------------------------------------------------------------------------------------------------------
K
A
D
P
S
H
F
E
L
L
K
V
L
G
Q
G
-
S
F
G
K
V
F
L
V
R
K
---
V
T
RPD
S
-
G
----
H
L
Y
A
M
K
V
L
-------------------------
I
-
L
-
A
--
D
-
V
-
N
H
P
F
V
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
-
E
--
V
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
G
L
D
H
L
H
S
-
L
G
--
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
-
E
E
G
----
H
I
K
L
T
D
F
G
L
S
K
E
---------------
G
T
V
E
Y
M
A
P
E
V
V
N
R
-----
Q
---
G
H
S
H
S
A
D
W
W
S
Y
G
V
L
M
F
E
M
L
T
G
-
S
L
P
F
Q
--
G
---
K
----
D
R
K
E
T
M
T
L
I
L
K
A
------
K
--
L
G
M
P
----
Q
F
L
S
T
E
A
Q
S
L
L
R
A
L
F
K
R
N
P
A
N
R
L
G
S
G
-
P
-
D
G
A
E
E
I
K
R
H
V
F
Y
S
T
I
D
---
W
N
K
L
Y
R
R
E
I
K
P
P
F
K
P
-------------------------------------------------------
67
PsiBlast_CBE
60.95
39%
-80
- C1 -
2F7X
1
KAPCA_BOVIN
E:
[16-343]
-------------------------------------------------------------------------------------------------------------------
V
K
E
F
L
A
K
A
K
E
D
F
L
K
K
W
E
N
P
A
Q
N
T
A
----
H
------
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
M
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
-
L
K
---
Q
I
E
H
T
L
N
E
K
R
I
-
L
-
Q
--
A
-
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
--
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
--
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
----
Y
I
Q
V
T
D
F
G
F
A
K
R
---
V
K
G
R
T
W
--
T
-
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
-----
K
---
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
F
--
A
---
D
----
Q
P
I
Q
I
Y
E
K
I
V
S
G
------
K
--
V
R
F
P
----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
L
-
K
-
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-
D
Y
E
E
E
E
I
R
V
S
I
N
E
K
C
G
K
E
F
S
E
F
--------------------
98
HHSearch
60.44
40%
-101
- C1 -
2ACX
1
GRK6_HUMAN
A:
[179-471]
--------------------------------------------------------------------------------------------------------------------------------------------------
Q
P
V
T
K
N
T
F
R
Q
Y
R
V
L
G
K
G
-
G
F
G
E
V
C
A
C
Q
V
---
R
A
---
T
-
G
----
K
M
Y
A
C
K
K
L
E
K
K
R
I
K
--
K
-
R
K
---
G
E
A
M
A
L
N
E
K
Q
I
-
L
-
E
--
K
-
V
-
N
S
R
F
V
V
S
L
A
Y
A
Y
E
T
K
D
A
L
C
L
V
L
T
L
M
N
G
G
D
L
K
F
H
I
Y
H
-
M
GQ
A
G
F
P
E
A
R
A
V
F
Y
A
A
E
I
C
C
G
L
E
D
L
H
R
-
E
R
--
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
-
D
H
G
----
H
I
R
I
S
D
L
G
L
A
V
H
-
V
P
E
G
Q
T
I
K
--
G
-
R
V
G
T
V
G
Y
M
A
P
E
V
V
K
N
-----
E
---
R
Y
T
F
S
P
D
W
W
A
L
G
C
L
L
Y
E
M
I
A
G
-
Q
S
P
F
Q
--
Q
---
R
K
K
K
I
K
R
E
E
V
E
R
L
V
K
E
V
------
P
--
E
E
Y
S
----
E
R
F
S
P
Q
A
R
S
L
C
S
Q
L
L
C
K
D
P
A
E
R
L
G
C
R
-
G
-
G
S
A
R
E
V
K
E
H
P
L
F
K
K
L
N
---
F
K
R
L
G
A
G
M
L
E
P
P
F
K
P
D
P
Q
A
I
Y
C
E
P
T
D
Q
D
F
Y
Q
K
F
A
T
G
S
V
P
I
P
W
Q
N
E
M
V
E
T
E
C
F
Q
E
L
N
V
F
G
L
D
G
S
-------
65
PsiBlast_CBE
60.31
39%
-81
- C1 -
2OH0
1
KAPCA_BOVIN
E:
[16-343]
-------------------------------------------------------------------------------------------------------------------
V
K
E
F
L
A
K
A
K
E
D
F
L
K
K
W
E
N
P
A
Q
N
T
A
----
H
------
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
M
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
-
L
K
---
Q
I
E
H
T
L
N
E
K
R
I
-
L
-
Q
--
A
-
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
--
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
--
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
----
Y
I
Q
V
T
D
F
G
F
A
K
R
---
V
K
G
R
T
W
--
T
-
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
-----
K
---
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
F
--
A
---
D
----
Q
P
I
Q
I
Y
E
K
I
V
S
G
------
K
--
V
R
F
P
----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
L
-
K
-
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-
D
Y
E
E
E
E
I
R
V
S
I
N
E
K
C
G
K
E
F
S
E
F
--------------------
32
PsiBlast_CBE
60.19
48%
-103
- C1 -
2R5T
1
SGK1_HUMAN
A:
[24-320]
---------------------------------------------------------------------------------------------------------------------------------
Q
I
N
L
G
P
S
S
N
P
----
H
--
A
K
P
S
--
D
F
H
F
L
K
V
I
G
K
G
-
S
F
G
K
V
L
L
A
R
H
---
K
A
---
E
-
E
----
V
F
Y
A
V
K
V
L
Q
K
K
A
I
L
-------------------
V
-
L
L
K
--
N
-
V
-
K
H
P
F
L
V
G
L
H
F
S
F
Q
T
A
D
K
L
Y
F
V
L
D
Y
I
N
G
G
E
L
F
Y
H
L
Q
R
-
E
--
R
C
F
L
E
P
R
A
R
F
Y
A
A
E
I
A
S
A
L
G
Y
L
H
S
-
L
N
--
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
-
S
Q
G
----
H
I
V
L
T
D
F
G
L
C
K
E
N
I
E
H
N
S
T
T
S
--
T
-
F
C
G
T
P
E
Y
L
A
P
E
V
L
H
K
-----
Q
---
P
Y
D
R
T
V
D
W
W
C
L
G
A
V
L
Y
E
M
L
Y
G
-
L
P
P
F
Y
--
S
---
R
----
N
T
A
E
M
Y
D
N
I
L
N
K
------
P
--
L
Q
L
K
----
P
N
I
T
N
S
A
R
H
L
L
E
G
L
L
Q
K
D
R
T
K
R
L
G
A
K
---
D
D
F
M
E
I
K
S
H
V
F
F
S
L
I
N
---
W
D
D
L
I
N
K
K
I
T
P
P
F
N
P
N
V
S
G
---------------------------------------------------
45
PsiBlast_CBE
59.90
45%
-104
- C1 -
2Z7S
1
KS6A1_HUMAN
A:
[24-308]
---------------------------------------------------------------------------------------------------------------------------------------------------
K
A
D
P
S
H
F
E
L
L
K
V
L
G
Q
G
-
S
F
G
K
V
F
L
V
R
K
---
V
T
RPD
S
-
G
----
H
L
Y
A
M
K
V
L
K
------------------------
I
-
L
-
A
--
D
-
V
-
N
H
P
F
V
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
-
E
--
V
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
G
L
D
H
L
H
S
-
L
G
--
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
-
E
E
G
----
H
I
K
L
T
D
F
G
L
S
K
E
---------------
G
T
V
E
Y
M
A
P
E
V
V
N
R
-----
Q
---
G
H
S
H
S
A
D
W
W
S
Y
G
V
L
M
F
E
M
L
T
G
-
S
L
P
F
Q
--
G
---
K
----
D
R
K
E
T
M
T
L
I
L
K
A
------
K
--
L
G
M
P
----
Q
F
L
S
T
E
A
Q
S
L
L
R
A
L
F
K
R
N
P
A
N
R
L
G
S
G
-
P
-
D
G
A
E
E
I
K
R
H
V
F
Y
S
T
I
D
---
W
N
K
L
Y
R
R
E
I
K
P
P
F
K
P
-------------------------------------------------------
74
Fugue
59.82
40%
-90
- C1 -
1CDK
2
KAPCA_PIG
A:
[8-350]
-------------------------------------------------------------------------------------------
K
G
S
E
Q
E
S
V
K
E
F
L
A
K
A
K
E
D
F
L
K
K
W
E
N
P
A
Q
N
T
A
-------------------------
H
--
L
D
Q
F
E
R
I
K
T
L
G
T
-G
S
F
G
R
V
M
L
V
K
H
---
K
E
---
T
G-----
N
H
F
A
M
K
I
L
D
K
Q
K
V
V
--
K
-
L
K
---
Q
I
E
H
T
L
N
E
K
R
I
-
L
-
Q
A
V----
N
F
P
F
L
V
K
L
E
Y
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
---
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
---
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q-
Q
G
----
Y
I
Q
V
T
D
F
G
F
A
K
R
V
-
K
--
G
--
R
TW
T
-
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
------KGY--
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y-
P
P
F
F
AD---------
Q
P
I
Q
I
Y
E
K
I
V
S
G
K
V
R
F
PS------------
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
L
-
K
-
D
G
V
N
D
I
K
N
H
K
W
F
A
---TT
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
I
R
V
S
I
-------------
N
E
K
C
G
K
E
F
S
E
F
--------
52
PsiBlast_CBE
58.88
47%
-96
- C1 -
4L3L
1
KS6B1_HUMAN
A:
[20-304]
---------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
L
L
R
V
L
G
K
G
-
G
Y
G
K
V
F
Q
V
R
K
VTG
A
N
---
T
-
G
----
K
I
F
A
M
K
V
L
K
K
A
M
I
V
R
N
A
-
K
D
----
T
A
H
T
K
A
E
R
N
I
-
L
-
E
--
E
-
V
-
K
H
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
-
E
--
G
I
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
-
K
G
--
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
-
H
Q
G
----
H
V
K
L
T
D
F
G
L
C
K
E
S
I
H
D
G
T
V
T
H
--
T
-
F
C
G
T
I
E
Y
M
A
P
E
I
L
M
R
-----
S
---
G
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
-
A
P
P
F
T
--
G
---
E
----
N
R
K
K
T
I
D
K
I
L
K
C
------
K
--
L
N
L
P
----
P
Y
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
R
L
G
A
G
-
P
-
G
D
A
G
E
V
Q
A
H
P
F
F
R
H
I
N
---
W
E
E
L
L
A
R
K
V
E
P
P
F
K
P
L
L
Q
S
---------------------------------------------------
46
PsiBlast_CBE
58.87
45%
-101
- C1 -
2Z7R
1
KS6A1_HUMAN
A:
[21-308]
------------------------------------------------------------------------------------------------------------------------------------------------GS
E
K
A
D
P
S
H
F
E
L
L
K
V
L
G
Q
G
-
S
F
G
K
V
F
L
V
R
K
---
V
T
RPD
S
-
G
----
H
L
Y
A
M
K
V
L
K
K
A
T
L
K
--
V
----------------
I
-
L
-
A
--
D
-
V
-
N
H
P
F
V
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
-
E
--
V
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
G
L
D
H
L
H
S
-
L
G
--
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
-
E
E
G
----
H
I
K
L
T
D
F
G
L
S
K
E
---------------
G
T
V
E
Y
M
A
P
E
V
V
N
R
-----
Q
---
G
H
S
H
S
A
D
W
W
S
Y
G
V
L
M
F
E
M
L
T
G
-
S
L
P
F
Q
--
G
---
K
----
D
R
K
E
T
M
T
L
I
L
K
A
------
K
--
L
G
M
P
----
Q
F
L
S
T
E
A
Q
S
L
L
R
A
L
F
K
R
N
P
A
N
R
L
G
S
G
-
P
-
D
G
A
E
E
I
K
R
H
V
F
Y
S
T
I
D
---
W
N
K
L
Y
R
R
E
I
K
P
P
F
K
P
-------------------------------------------------------
48
PsiBlast_CBE
58.56
44%
-89
- C1 -
5D9L
2
?
A:
[13-322]
-----------------------------------------------------------------------------------------------------------------------------------
E
I
-
A
I
T
H
H
V
K
E
G
H
--
E
K
A
D
P
S
Q
F
E
L
L
K
V
L
G
Q
G
-
S
F
G
K
V
F
L
V
K
----
K
I
---
S
-
G
SDAR
Q
L
Y
A
M
K
V
L
K
K
A
T
L
K
--
V
-
R
D
---
R
V
-
R
T
K
M
E
R
D
I
-
L
-
V
--
E
-
V
-
N
H
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
-
E
--
V
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
S
-
L
G
--
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
-
E
E
G
----
H
I
K
L
T
D
F
G
L
S
K
E
---------------
G
T
V
E
Y
M
A
P
E
V
V
N
R
-----
R
---
G
H
T
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
-
T
L
P
F
Q
--
G
---
K
----
D
R
K
E
T
M
T
M
I
L
K
A
------
K
--
L
G
M
P
----
Q
F
L
S
P
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
R
L
G
A
G
-
P
-
D
G
V
E
E
I
K
R
H
S
F
F
S
T
I
D
---
W
N
K
L
Y
R
R
E
I
H
P
P
F
K
P
A
T
G
R
P
E
D
T
F
Y
F
D
P
------------------------------------------
44
PsiBlast_CBE
58.47
46%
-100
- C1 -
3G51
1
KS6A3_MOUSE
A:
[18-304]
-----------------------------------------------------------------------------------------------------------------------------------------------
H
--
E
K
A
D
P
S
Q
F
E
L
L
K
V
L
G
Q
G
-
S
F
G
K
V
F
L
V
K
----
K
I
---
S
-
G
SDAR
Q
L
Y
A
M
K
V
L
K
K
A
T
L
K
--
V
-
R
D
-------------
I
-
L
-
V
--
E
-
V
-
N
H
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
-
E
--
V
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
S
-
L
G
--
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
-
E
E
G
----
H
I
K
L
T
D
F
G
L
S
K
E
S
I
--------------
T
V
E
Y
M
A
P
E
V
V
N
R
-----
R
---
G
H
T
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
-
T
L
P
F
Q
--
G
---
K
----
D
R
K
E
T
M
T
M
I
L
K
A
------
K
--
L
G
M
P
----
Q
F
L
S
P
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
R
L
G
A
G
-
P
-
D
G
V
E
E
I
K
R
H
S
F
F
S
T
I
D
---
W
N
K
L
Y
R
R
E
I
H
P
P
F
K
P
-------------------------------------------------------
53
PsiBlast_CBE
58.25
47%
-96
- C1 -
4L3J
1
KS6B1_HUMAN
A:
[20-304]
---------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
L
L
R
V
L
G
K
G
-
G
Y
G
K
V
F
Q
V
R
K
VTG
A
N
---
T
-
G
----
K
I
F
A
M
K
V
L
K
K
A
M
I
V
RN
A
-
K
D
----
T
A
H
T
K
A
E
R
N
I
-
L
-
E
--
E
-
V
-
K
H
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
-
E
--
G
I
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
-
K
G
--
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
-
H
Q
G
----
H
V
K
L
T
D
F
G
L
C
K
E
S
I
H
D
G
T
V
T
H
--
T
-
F
C
G
T
I
E
Y
M
A
P
E
I
L
M
R
-----
S
---
G
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
-
A
P
P
F
T
--
G
---
E
----
N
R
K
K
T
I
D
K
I
L
K
C
------
K
--
L
N
L
P
----
P
Y
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
R
L
G
A
G
-
P
-
G
D
A
G
E
V
Q
A
H
P
F
F
R
H
I
N
---
W
E
E
L
L
A
R
K
V
E
P
P
F
K
P
L
L
Q
S
---------------------------------------------------
31
PsiBlast_CBE
58.01
48%
-98
- C1 -
3HDM
1
SGK1_HUMAN
A:
[23-320]
--------------------------------------------------------------------------------------------------------------------------------
Q
Q
I
N
L
G
P
S
S
N
P
----
H
--
A
K
P
S
--
D
F
H
F
L
K
V
I
G
K
G
-
S
F
G
K
V
L
L
A
R
H
---
K
A
---
E
-
E
----
V
F
Y
A
V
K
V
L
Q
K
K
A
I
L
-------------------
V
-
L
L
K
--
N
-
V
-
K
H
P
F
L
V
G
L
H
F
S
F
Q
T
A
D
K
L
Y
F
V
L
D
Y
I
N
G
G
E
L
F
Y
H
L
Q
R
-
E
--
R
C
F
L
E
P
R
A
R
F
Y
A
A
E
I
A
S
A
L
G
Y
L
H
S
-
L
N
--
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
-
S
Q
G
----
H
I
V
L
T
D
F
G
L
C
K
E
N
I
E
H
N
S
T
T
S
--
T
-
F
C
G
T
P
E
Y
L
A
P
E
V
L
H
K
-----
Q
---
P
Y
D
R
T
V
D
W
W
C
L
G
A
V
L
Y
E
M
L
Y
G
-
L
P
P
F
Y
--
S
---
R
----
N
T
A
E
M
Y
D
N
I
L
N
K
------
P
--
L
Q
L
K
----
P
N
I
T
N
S
A
R
H
L
L
E
G
L
L
Q
K
D
R
T
K
R
L
G
A
K
---
D
D
F
M
E
I
K
S
H
V
F
F
S
L
I
N
---
W
D
D
L
I
N
K
K
I
T
P
P
F
N
P
N
V
S
G
---------------------------------------------------
30
PsiBlast_CBE
57.15
48%
-102
- C1 -
3HDN
1
SGK1_HUMAN
A:
[24-316]
---------------------------------------------------------------------------------------------------------------------------------
Q
I
N
L
G
P
S
S
N
P
----
H
--
A
K
P
S
--
D
F
H
F
L
K
V
I
G
K
G
-
S
F
G
K
V
L
L
A
R
H
---
K
A
---
E
-
E
----
V
F
Y
A
V
K
V
L
Q
K
K
A
I
L
-------------------
V
-
L
L
K
--
N
-
V
-
K
H
P
F
L
V
G
L
H
F
S
F
Q
T
A
D
K
L
Y
F
V
L
D
Y
I
N
G
G
E
L
F
Y
H
L
Q
R
-
E
--
R
C
F
L
E
P
R
A
R
F
Y
A
A
E
I
A
S
A
L
G
Y
L
H
S
-
L
N
--
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
-
S
Q
G
----
H
I
V
L
T
D
F
G
L
C
K
E
N
I
E
H
N
S
T
T
S
--
T
-
F
C
G
T
P
E
Y
L
A
P
E
V
L
H
K
-----
Q
---
P
Y
D
R
T
V
D
W
W
C
L
G
A
V
L
Y
E
M
L
Y
G
-
L
P
P
F
Y
--
S
---
R
----
N
T
A
E
M
Y
D
N
I
L
N
K
------
P
--
L
Q
L
K
----
P
N
I
T
N
S
A
R
H
L
L
E
G
L
L
Q
K
D
R
T
K
R
L
G
A
K
---
D
D
F
M
E
I
K
S
H
V
F
F
S
L
I
N
---
W
D
D
L
I
N
K
K
I
T
P
P
F
N
P
-------------------------------------------------------
56
PsiBlast_CBE
56.51
46%
-102
- C1 -
4GUE
1
KS6A3_MOUSE
A:
[19-305]
-----------------------------------------------------------------------------------------------------------------------------------------------
H
--
E
K
A
D
P
S
Q
F
E
L
L
K
V
L
G
Q
G
-
S
F
G
K
V
F
L
V
K
----
K
I
---
S
-
G
SDAR
Q
L
Y
A
M
K
V
L
K
K
A
T
L
K
--
V
-
R
D
---
R
V
----------
L
-
V
--
E
-
V
-
N
H
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
-
E
--
V
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
S
-
L
G
--
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
-
E
E
G
----
H
I
K
L
T
D
F
G
L
S
K
E
-----
K
K
A
Y
--
S
-
F
C
G
T
V
E
Y
M
A
P
E
V
V
N
R
-----
R
---
G
H
T
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
-
T
L
P
F
Q
--
G
---
K
----
D
R
K
E
T
M
T
M
I
L
K
A
------
K
--
L
G
M
P
----
Q
F
L
S
P
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
R
L
G
A
G
-
P
-
D
G
V
E
E
I
K
R
H
S
F
F
S
T
I
D
---
W
N
K
L
Y
R
R
E
I
H
P
P
F
K
P
-------------------------------------------------------
58
PsiBlast_CBE
56.43
46%
-102
- C1 -
3UBD
1
KS6A3_MOUSE
A:
[18-304]
-----------------------------------------------------------------------------------------------------------------------------------------------
H
--
E
K
A
D
P
S
Q
F
E
L
L
K
V
L
G
Q
G
-
S
F
G
K
V
F
L
V
K
----
K
I
---
S
-
G
SDAR
Q
L
Y
A
M
K
V
L
K
K
A
T
L
K
--
V
-
R
D
---
R
V
-------
D
I
-
L
-
V
--
E
-
V
-
N
H
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
-
E
--
V
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
S
-
L
G
--
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
-
E
E
G
----
H
I
K
L
T
D
F
G
L
S
K
E
-----
K
K
A
Y
--
S
-
F
C
G
T
V
E
Y
M
A
P
E
V
V
N
R
-----
R
---
G
H
T
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
-
T
L
P
F
Q
--
G
---
K
----
D
R
K
E
T
M
T
M
I
L
K
A
------
K
--
L
G
M
P
----
Q
F
L
S
P
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
R
L
G
A
G
-
P
-
D
G
V
E
E
I
K
R
H
S
F
F
S
T
I
D
---
W
N
K
L
Y
R
R
E
I
H
P
P
F
K
P
-------------------------------------------------------
57
PsiBlast_CBE
56.30
46%
-100
- C1 -
4EL9
1
KS6A3_MOUSE
A:
[19-305]
-----------------------------------------------------------------------------------------------------------------------------------------------
H
--
E
K
A
D
P
S
Q
F
E
L
L
K
V
L
G
Q
G
-
S
F
G
K
V
F
L
V
K
----
K
I
---
S
-
G
SDAR
Q
L
Y
A
M
K
V
L
K
K
A
T
L
K
--
V
-
R
D
---
R
V
-
R
-----
D
I
-
L
-
V
--
E
-
V
-
N
H
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
-
E
--
V
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
S
-
L
G
--
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
-
E
E
G
----
H
I
K
L
T
D
F
G
L
S
K
E
S
---
E
K
K
A
Y
--
S
-
F
C
G
T
V
E
Y
M
A
P
E
V
V
N
R
-----
R
---
G
H
T
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
-
T
L
P
F
Q
--
G
---
K
----
D
R
K
E
T
M
T
M
I
L
K
A
------
K
--
L
G
M
P
----
Q
F
L
S
P
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
R
L
G
A
G
-
P
-
D
G
V
E
E
I
K
R
H
S
F
F
S
T
I
D
---
W
N
K
L
Y
R
R
E
I
H
P
P
F
K
P
-------------------------------------------------------
54
PsiBlast_CBE
55.88
48%
-110
- C1 -
4RLO
4
KS6B1_HUMAN
B:
[7-287]
---------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
L
L
R
V
L
G
K
G
-
G
Y
G
K
V
F
Q
V
R
K
VTG
A
N
---
T
-
G
----
K
I
F
A
M
K
V
L
K
K
----------------------------------
K
H
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
-
E
--
G
I
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
-
K
G
--
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
-
H
Q
G
----
H
V
K
L
T
D
F
G
L
C
K
E
S
I
--------------
T
I
E
Y
M
A
P
E
I
L
M
R
-----
S
---
G
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
-
A
P
P
F
T
--
G
---
E
----
N
R
K
K
T
I
D
K
I
L
K
C
------
K
--
L
N
L
P
----
P
Y
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
R
L
G
A
G
-
P
-
G
D
A
G
E
V
Q
A
H
P
F
F
R
H
I
N
---
W
E
E
L
L
A
R
K
V
E
P
P
F
K
P
L
------------------------------------------------------
102
HHSearch
55.70
45%
-104
- C1 -
3UBD
1
KS6A3_MOUSE
A:
[20-304]
---------------------------------------------------------------------------------------------------------------------------------------------------
K
A
D
P
S
Q
F
E
L
L
K
V
L
G
Q
G
-
S
F
G
K
V
F
L
V
K
K
---
I
S
GSD
A
-
R
----
Q
L
Y
A
M
K
V
L
K
K
A
T
L
K
--
V
-
R
----
D
R
V
------
D
I
-
L
-
V
--
E
-
V
-
N
H
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
-
E
--
V
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
S
-
L
G
--
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
-
E
E
G
----
H
I
K
L
T
D
F
G
L
S
K
E
-----
K
K
A
Y
--
S
-
F
C
G
T
V
E
Y
M
A
P
E
V
V
N
R
-----
R
---
G
H
T
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
-
T
L
P
F
Q
--
G
---
K
----
D
R
K
E
T
M
T
M
I
L
K
A
------
K
--
L
G
M
P
----
Q
F
L
S
P
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
R
L
G
A
G
-
P
-
D
G
V
E
E
I
K
R
H
S
F
F
S
T
I
D
---
W
N
K
L
Y
R
R
E
I
H
P
P
F
K
P
-------------------------------------------------------
37
PsiBlast_CBE
54.53
47%
-106
- C1 -
3A60
1
KS6B1_HUMAN
B:
[19-300]
---------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
L
L
R
V
L
G
K
G
-
G
Y
G
K
V
F
Q
V
R
K
VTG
A
N
---
T
-
G
----
K
I
F
A
M
K
V
L
K
K
----------------------------------
K
H
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
-
E
--
G
I
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
-
K
G
--
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
-
H
Q
G
----
H
V
K
L
T
D
F
G
L
C
K
E
S
-------------
C
G
T
I
E
Y
M
A
P
E
I
L
M
R
-----
S
---
G
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
-
A
P
P
F
T
--
G
---
E
----
N
R
K
K
T
I
D
K
I
L
K
C
------
K
--
L
N
L
P
----
P
Y
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
R
L
G
A
G
-
P
-
G
D
A
G
E
V
Q
A
H
P
F
F
R
H
I
N
---
W
E
E
L
L
A
R
K
V
E
P
P
F
K
P
L
------------------------------------------------------
36
PsiBlast_CBE
53.68
47%
-106
- C1 -
3A61
1
KS6B1_HUMAN
A:
[19-299]
---------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
L
L
R
V
L
G
K
G
-
G
Y
G
K
V
F
Q
V
R
K
V
T
G
A
N
---
T
-
G
----
K
I
F
A
M
K
V
L
K
--------------------
A
E
R
N
I
-
L
-
E
--
E
-
V
-
K
H
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
-
E
--
G
I
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
-
K
G
--
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
-
H
Q
G
----
H
V
K
L
T
D
F
G
-------------------
G
T
I
E
Y
M
A
P
E
I
L
M
R
-----
S
---
G
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
-
A
P
P
F
T
--
G
---
E
----
N
R
K
K
T
I
D
K
I
L
K
C
------
K
--
L
N
L
P
----
P
Y
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
R
L
G
A
G
-
P
-
G
D
A
G
E
V
Q
A
H
P
F
F
R
H
I
N
---
W
E
E
L
L
A
R
K
V
E
P
P
F
K
P
-------------------------------------------------------
38
PsiBlast_CBE
52.95
47%
-99
- C1 -
3A60
1
KS6B1_HUMAN
A:
[19-299]
---------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
L
L
R
V
L
G
K
G
-
G
Y
G
K
V
F
Q
V
R
K
V
T
G
A
N
---
T
-
G
----
K
I
F
A
M
K
V
L
K
K
A
M
----------------
K
A
E
R
N
I
-
L
-
E
--
E
-
V
-
K
H
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
-
E
--
G
I
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
-
K
G
--
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
-
H
Q
G
----
H
V
K
L
T
D
F
G
L
C
K
E
----------------
T
I
E
Y
M
A
P
E
I
L
M
R
-----
S
---
G
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
-
A
P
P
F
T
--
G
---
E
----
N
R
K
K
T
I
D
K
I
L
K
C
------
K
--
L
N
L
P
----
P
Y
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
R
L
G
A
G
-
P
-
G
D
A
G
E
V
Q
A
H
P
F
F
R
H
I
N
---
W
E
E
L
L
A
R
K
V
E
P
P
F
K
P
-------------------------------------------------------
103
HHSearch
47.94
31%
-89
- C1 -
2Y0A
1
DAPK1_HUMAN
A:
[12-288]
--------------------------------------------------------------------------------------------------------------------------------------------------------
Y
Y
D
T
G
E
E
L
G
S
G
-
Q
F
A
V
V
K
K
C
R
E
---
K
S
---
T
-
G
----
L
Q
Y
A
A
K
F
I
K
K
R
R
T
K
--
S
-
S
R
RGV
S
R
E
D
I
E
R
E
V
S
I
-
L
-
K
--
E
-
I
-
Q
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
-
K
--
E
S
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
-
L
Q
--
I
A
H
F
D
L
K
P
E
N
I
M
L
L
-
D
R
N
VP
K
P
R
I
K
I
I
D
F
G
L
A
H
K
-
I
D
F
G
N
E
F
K
--
N
-
I
F
G
T
P
E
F
V
A
P
E
I
V
N
Y
-----
E
---
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
-
A
S
P
F
L
--
G
---
D
----
T
K
Q
E
T
L
A
N
V
S
A
V
------
N
--
Y
E
F
E
DEYF
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
-------
T
I
Q
D
S
L
Q
H
P
W
I
K
P
K
D
---
T
Q
Q
A
L
S
R
K
A
S
A
V
N
M
E
K
F
K
K
F
A
A
R
-----------------------------------------------