@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : ALK_HUMAN: (2015-10-03 )
MGAIGLLWLLPLLLSTAAVGSGMGTGQRAGSPAAGPPLQPREPLSYSRLQRKSLAVDFVVPSLFRVYARDLLLPPSSSELKAGRPEARGSLALDCAPLLRLLGPAPGVSWTAGSPAPAEARTLSRVLKGGSVRKLRRAKQLVLELGEEAILEGCVGPPGEAAVGLLQFNLSELFSWWIRQGEGRLRIRLMPEKKASEVGREGRLSAAIRASQPRLLFQIFGTGHSSLESPTNMPSPSPDYFTWNLTWIMKDSFPFLSHRSRYGLECSFDFPCELEYSPPLHDLRNQSWSWRRIPSEEASQMDLLDGPGAERSKEMPRGSFLLLNTSADSKHTILSPWMRSSSEHCTLAVSVHRHLQPSGRYIAQLLPHNEAAREILLMPTPGKHGWTVLQGRIGRPDNPFRVALEYISSGNRSLSAVDFFALKNCSEGTSPGSKMALQSSFTCWNGTVLQLGQACDFHQDCAQGEDESQMCRKLPVGFYCNFEDGFCGWTQGTLSPHTPQWQVRTLKDARFQDHQDHALLLSTTDVPASESATVTSATFPAPIKSSPCELRMSWLIRGVLRGNVSLVLVENKTGKEQGRMVWHVAAYEGLSLWQWMVLPLLDVSDRFWLQMVAWWGQGSRAIVAFDNISISLDCYLTISGEDKILQNTAPKSRNLFERNPNKELKPGENSPRQTPIFDPTVHWLFTTCGASGPHGPTQAQCNNAYQNSNLSVEVGSEGPLKGIQIWKVPATDTYSISGYGAAGGKGGKNTMMRSHGVSVLGIFNLEKDDMLYILVGQQGEDACPSTNQLIQKVCIGENNVIEEEIRVNRSVHEWAGGGGGGGGATYVFKMKDGVPVPLIIAAGGGGRAYGAKTDTFHPERLENNSSVLGLNGNSGAAGGGGGWNDNTSLLWAGKSLQEGATGGHSCPQAMKKWGWETRGGFGGGGGGCSSGGGGGGYIGGNAASNNDPEMDGEDGVSFISPLGILYTPALKVMEGHGEVNIKHYLNCSHCEVDECHMDPESHKVICFCDHGTVLAEDGVSCIVSPTPEPHLPLSLILSVVTSALVAALVLAFSGIMIVYRRKHQELQAMQMELQSPEYKLSKLRTSTIMTDYNPNYCFAGKTSSISDLKEVPRKNITLIRGLGHGAFGEVYEGQVSGMPNDPSPLQVAVKTLPEVCSEQDELDFLMEALIISKFNHQNIVRCIGVSLQSLPRFILLELMAGGDLKSFLRETRPRPSQPSSLAMLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGPGRVAKIGDFGMARDIYRASYYRKGGCAMLPVKWMPPEAFMEGIFTSKTDTWSFGVLLWEIFSLGYMPYPSKSNQEVLEFVTSGGRMDPPKNCPGPVYRIMTQCWQHQPEDRPNFAIILERIEYCTQDPDVINTALPIEYGPLVEEEEKVPVRPKDPEGVPPLLVSQQAKREEERSPAAPPPLPTTSSGKAAKKPTAAEISVRVPRGPAVEGGHVNMAFSQSNPPSELHKVHGSRNKPTSLWNPTYGSWFTEKPTKKNNPIAKKEPHDRGNLGLEGSCTVPPNVATGRLPGASLLLEPSSLTANMKEVPLFRLRHFPCGNVNYGYQQQGLPLEAATAPGAGHYEDTILKSKNSMNQPGP
Atome Classification :
(77 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770.......780.......790.......800.......810.......820.......830.......840.......850.......860.......870.......880.......890.......900.......910.......920.......930.......940.......950.......960.......970.......980.......990.......1000......1010......1020......1030......1040......1050......1060......1070......1080......1090......1100......-------1110......1120......1130.-.....1140..-..-.---...1150-.......1160......1170.-.....1180......1190......1200......1210-------.----.------.--------.--..-1220-..---.......1230......1240......1250......1260--......1270......1280......1290......1300......1310......1320......1330......1340......1350......1360......1370......1380-........1390......1400......1410......1420......1430......1440......1450......1460......1470......1480......1490......1500......1510......1520......1530......1540......1550......1560......1570......1580......1590......1600......1610......1620
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MGA
I
G
L
L
W
L
L
P
L
L
L
S
T
A
AVGSGMGTGQRAGSPAAGPPLQPREPL
S
Y
S
R
L
Q
R
K
S
L
A
V
D
F
V
V
P
S
L
F
R
V
Y
A
R
D
LLLPPSSSELKAGRPEARGSLAL
D
C
A
P
L
L
R
LLGPAPGVSWTAGSPAP
A
E
A
R
T
L
S
R
V
L
KGG
S
V
R
K
L
R
R
A
K
Q
L
V
L
E
L
G
E
E
A
I
L
E
GCVGPP
G
E
A
A
V
G
L
L
Q
F
N
L
S
E
L
F
S
W
W
I
RQGE
G
R
L
R
I
R
LMP
E
K
K
A
S
E
VGREGR
L
S
A
A
IRASQ
P
R
L
L
F
Q
I
FGTGHSSLESPTNMPSPSP
D
Y
F
T
W
N
L
T
W
I
MKDSF
P
F
L
SHRSRYGLECSFDFPCELEYSP
P
L
H
D
L
RNQSWSWRRIP
S
E
E
ASQMDLLDGPGAERSKEMPRG
S
F
L
L
L
NTSADSKHT
I
L
S
P
W
M
RSSSE
H
C
T
L
A
V
S
V
H
RHLQPS
G
R
Y
I
A
Q
LLPH
N
E
A
A
R
E
I
L
L
MPTPGKHG
W
T
V
LQGRIGRPDN
P
F
R
V
A
L
E
Y
I
SSGNRS
L
S
A
V
D
F
F
A
LKNCSEGTSPGS
K
M
A
L
QSSFTCWN
G
T
V
L
QLGQAC
D
F
H
Q
D
CAQGE
D
E
S
Q
M
C
R
KLP
V
G
F
Y
C
NFEDGFCGWTQGTLSPHTPQ
W
Q
V
R
TLKDARFQDHQD
H
A
L
L
L
S
TTDVPASESA
T
V
TSATFPAPIKSS
P
C
E
L
R
M
S
W
L
I
R
G
V
LRG
N
V
S
L
V
L
V
ENKTGKEQG
R
M
V
W
H
V
A
A
YE
G
L
S
L
W
Q
W
M
V
L
P
L
LDV
S
D
R
F
W
L
Q
M
V
A
W
WGQG
S
R
A
I
V
A
F
D
N
I
S
I
S
L
D
C
Y
L
T
ISGED
K
I
L
QNTAPKSRNLFERNPNKELKPGENSPRQTPIFDP
T
V
H
W
L
F
TTCGASGPHGPT
Q
A
Q
CNNAYQNS
N
L
S
V
E
VGSEGPLK
G
I
Q
I
W
KVPAT
D
T
Y
S
I
SGYGAAGGKGGKN
T
M
MRSHG
V
S
V
L
G
I
F
NLEKD
D
M
L
Y
I
L
VGQQGEDACP
S
T
N
Q
L
I
Q
K
V
CIGENN
V
I
E
E
E
I
R
VNR
S
V
H
EWAGGGGGGGG
A
T
Y
V
F
KMKDGVP
V
P
L
I
I
A
AGGGGRAYGAKTDTF
H
P
E
RLENNS
S
V
L
G
LNGNSGAAGGGGGWNDNT
S
L
L
WAGK
S
L
QEGATGGH
S
C
P
Q
A
M
K
KWGWETRGGFGGGGGGCSSGGGGGGYIGGNAASNNDPEMDGEDG
V
S
F
I
S
P
L
G
I
L
Y
T
P
A
L
K
V
MEGHG
E
V
N
I
K
H
Y
LNCSHCE
V
D
E
CHMDPES
H
K
V
I
C
F
CDHG
T
V
L
A
EDG
V
S
C
I
VSPTPEPHL
P
L
S
L
I
L
S
V
V
T
S
A
L
V
A
A
L
V
L
A
F
S
G
I
M
I
V
Y
R
R
K
H
Q
E
L
Q
A
M
Q
M
E
LQSP
E
Y
K
L
S
K
L
R
T
S
T
I
MTDYNP
N
Y
C
FAGKTS
S
I
S
D
L
K
-------EVPRKN
I
T
L
I
R
GLGHGAFGEVYEGQ-VSGMPND--P
S
-
P
L
-
Q
---
V
A
V
K
T
L
--
P
E
V
CSE
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
KF-
N
H
Q
N
I
V
R
C
I
G
V
S
L
Q
S
L
P
R
F
I
L
L
E
L
MAGG
D
L
K
S
F
L
R
ETRP-------R----P------S--------Q--P
S
-
S
----
L
A
---
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
EN
H
F
I
H
R
D
IAAR
N
C
L
L
TCPGPG--
R
V
A
KIGDF
G
M
A
R
D
I
Y
R
A
S
YYRKGG
C
A
MLPVKWM
P
P
E
A
F
M
E
G
I
FTSKTDT
W
S
F
G
V
L
L
W
E
I
F
SLGYMPYPSKS
N
Q
E
V
L
E
F
V
T
SGGRMDPPKNCP
G
P
V
Y
R
I
M
T
Q
C
W
QHQPEDRP
N
F
A
I
I
L
E
---
R
I
E
Y
CTQDPDVINTALPIEYGPLVEEEEKVPVRPKDPEGVP
P
L
L
V
S
Q
Q
A
K
R
E
EERSPAAPPPLPTTSSGKAAKKPT
A
A
E
I
S
V
RVPRGPAVEGG
H
V
N
M
A
FSQSN
P
P
S
E
L
H
K
VHGSRNKPTSLWNPTYGSWFTEKPTKKNNPIAKKEPHDRGNLGLEGSCTVPPNVATGRLPG
A
S
L
L
LEPSSLTANMKEV
P
L
F
R
LRHFPCGNVNYGYQQQGLPLEAATAPGAGH
Y
E
D
T
I
LKSKNSMNQPGP
3
PsiBlast_PDB
90.86
100%
-105
- C1 -
3AOX
5
A:
[19-334]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
T
I
M
T
D
Y
N
P
N
Y
C
F
A
G
K
T
S
S
I
S
D
L
K
-------
E
V
P
R
K
N
I
T
L
I
R
G
L
G
----
G
E
V
Y
E
G
Q
-
V
S
----------
P
L
-
Q
---
V
A
V
K
T
L
--
P
E
V
C
S
E
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
-
N
H
Q
N
I
V
R
C
I
G
V
S
L
Q
S
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
P
-------
R
----
P
------
S
--------
Q
--
P
S
-
S
----
L
A
---
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
C
P
G
P
G
--
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
A
-------
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
M
P
Y
P
S
K
S
N
Q
E
V
L
E
F
V
T
S
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
---
R
I
E
Y
C
T
Q
D
P
D
V
I
N
T
A
L
P
I
E
Y
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
90.45
99%
-101
- C1 -
4FOD
2
A:
[8-328]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
S
T
I
M
T
D
Y
N
P
N
Y
S
F
A
G
K
T
S
S
I
S
D
L
K
-------
E
V
P
R
K
N
I
T
L
I
R
G
L
G
H
G
A
F
G
E
V
Y
E
G
Q
-
V
S
--------
S
-
P
L
-
Q
---
V
A
V
K
T
L
--
P
E
V
C
S
E
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
-
N
H
Q
N
I
V
R
C
I
G
V
S
L
Q
S
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
P
-------
R
----
P
------
S
--------
Q
--
P
S
-
S
----
L
A
---
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
C
P
G
P
G
--
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
A
-------
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
M
P
Y
P
S
K
S
N
Q
E
V
L
E
F
V
T
S
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
---
R
I
E
Y
C
T
Q
D
P
D
V
I
N
T
A
L
P
I
E
Y
G
P
L
V
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
90.14
99%
-103
- C1 -
3LCS
3
A:
[30-333]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
C
F
A
G
K
T
S
S
I
S
D
L
K
-------
E
V
P
R
K
N
I
T
L
I
R
G
L
G
H
G
A
F
G
E
V
Y
E
G
Q
-
V
S
G
M
P
N
D
--
P
S
-
P
L
-
Q
---
V
A
V
K
T
L
--
P
E
V
C
S
E
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
-
N
H
Q
N
I
V
R
C
I
G
V
S
L
Q
S
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
P
-------
R
----
P
------
S
--------
Q
--
P
S
-
S
----
L
A
---
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
C
P
G
P
G
--
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
A
G
Y
Y
R
K
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
M
P
Y
P
S
K
S
N
Q
E
V
L
E
F
V
T
S
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
---
R
I
E
Y
C
T
Q
D
P
D
V
I
N
T
A
L
P
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
90.04
99%
-101
- C1 -
4DCE
1
ALK_HUMAN
A:
[16-325]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
P
N
Y
S
F
A
G
K
T
S
S
I
S
D
L
K
-------
E
V
P
R
K
N
I
T
L
I
R
G
L
G
H
---
G
E
V
Y
E
G
Q
-
V
S
-------
P
S
-
P
L
-
Q
---
V
A
V
K
T
L
--
P
E
V
C
S
E
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
-
N
H
Q
N
I
V
R
C
I
G
V
S
L
Q
S
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
P
-------
R
----
P
------
S
--------
Q
--
P
S
-
S
----
L
A
---
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
C
P
G
P
G
--
R
V
A
K
I
G
D
F
--------------
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
M
P
Y
P
S
K
S
N
Q
E
V
L
E
F
V
T
S
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
---
R
I
E
Y
C
T
Q
D
P
D
V
I
N
T
A
L
P
I
E
Y
G
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
34
PsiBlast_CBE
89.93
100%
-102
- C1 -
2XB7
1
A:
[3-309]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
Y
C
F
A
G
K
T
S
S
I
S
D
L
K
-------
E
V
P
R
K
N
I
T
L
I
R
G
L
G
H
G
A
F
G
E
V
Y
E
G
Q
-
V
S
----------
P
L
-
Q
---
V
A
V
K
T
L
--
P
E
V
C
S
E
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
-
N
H
Q
N
I
V
R
C
I
G
V
S
L
Q
S
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
P
-------
R
----
P
------
S
--------
Q
--
P
S
-
S
----
L
A
---
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
C
P
G
P
G
--
R
V
A
K
I
G
D
F
G
M
A
--------------
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
M
P
Y
P
S
K
S
N
Q
E
V
L
E
F
V
T
S
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
---
R
I
E
Y
C
T
Q
D
P
D
V
I
N
T
A
L
P
I
E
Y
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
89.68
99%
-101
- C1 -
4MKC
3
A:
[50-358]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
P
N
Y
C
F
A
G
K
T
S
S
I
S
D
L
K
-------
E
V
P
R
K
N
I
T
L
I
R
G
L
G
H
G
A
F
G
E
V
Y
E
G
Q
-
V
S
--------
S
-
P
L
-
Q
---
V
A
V
K
T
L
--
P
E
V
C
S
E
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
-
N
H
Q
N
I
V
R
C
I
G
V
S
L
Q
S
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
P
-------
R
----
P
------
S
--------
Q
--
P
S
-
S
----
L
A
---
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
C
P
G
P
G
--
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
A
G
Y
Y
R
K
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
M
P
Y
P
S
K
S
N
Q
E
V
L
E
F
V
T
S
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
---
R
I
E
Y
C
T
Q
D
P
D
V
I
N
T
A
L
P
I
E
Y
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
89.62
99%
-102
- C1 -
4FOC
1
A:
[36-345]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
P
N
Y
S
F
A
G
K
T
S
S
I
S
D
L
K
-------
E
V
P
R
K
N
I
T
L
I
R
G
L
G
H
G
A
F
G
E
V
Y
E
G
Q
-
V
S
--------
S
-
P
L
-
Q
---
V
A
V
K
T
L
--
P
E
V
C
S
E
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
-
N
H
Q
N
I
V
R
C
I
G
V
S
L
Q
S
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
P
-------
R
----
P
------
S
--------
Q
--
P
S
-
S
----
L
A
---
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
C
P
G
P
G
--
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
--------
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
M
P
Y
P
S
K
S
N
Q
E
V
L
E
F
V
T
S
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
---
R
I
E
Y
C
T
Q
D
P
D
V
I
N
T
A
L
P
I
E
Y
G
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
88.84
99%
-99
- C1 -
3L9P
4
A:
[50-357]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
P
N
Y
C
F
A
G
K
T
S
S
I
S
D
L
K
-------
E
V
P
R
K
N
I
T
L
I
R
G
L
G
H
G
A
F
G
E
V
Y
E
G
Q
-
V
S
G
-------
S
-
P
L
-
Q
---
V
A
V
K
T
L
--
P
E
V
C
S
E
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
-
N
H
Q
N
I
V
R
C
I
G
V
S
L
Q
S
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
P
-------
R
----
P
------
S
--------
Q
--
P
S
-
S
----
L
A
---
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
C
P
G
P
G
--
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
A
G
Y
Y
R
K
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
M
P
Y
P
S
K
S
N
Q
E
V
L
E
F
V
T
S
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
---
R
I
E
Y
C
T
Q
D
P
D
V
I
N
T
A
L
P
I
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
88.69
99%
-104
- C1 -
4DCE
1
B:
[17-325]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
N
Y
S
F
A
G
K
T
S
S
I
S
D
L
K
-------
E
V
P
R
K
N
I
T
L
I
R
G
L
G
H
----
E
V
Y
E
G
Q
-
V
S
--------
S
-
P
L
-
Q
---
V
A
V
K
T
L
--
P
E
V
C
S
E
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
-
N
H
Q
N
I
V
R
C
I
G
V
S
L
Q
S
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
P
-------
R
----
P
------
S
--------
Q
--
P
S
-
S
----
L
A
---
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
C
P
G
P
G
--
R
V
A
K
I
G
D
F
---------------
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
M
P
Y
P
S
K
S
N
Q
E
V
L
E
F
V
T
S
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
---
R
I
E
Y
C
T
Q
D
P
D
V
I
N
T
A
L
P
I
E
Y
G
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
88.24
99%
-99
- C1 -
3LCT
3
A:
[27-334]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
P
N
Y
C
F
A
G
K
T
S
S
I
S
D
L
K
-------
E
V
P
R
K
N
I
T
L
I
R
G
L
G
H
G
A
F
G
E
V
Y
E
G
Q
-
V
S
G
M
P
N
D
--
P
S
-
P
L
-
Q
---
V
A
V
K
T
L
--
P
E
V
C
S
E
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
-
N
H
Q
N
I
V
R
C
I
G
V
S
L
Q
S
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
P
-------
R
----
P
------
S
--------
Q
--
P
S
-
S
----
L
A
---
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
C
P
G
P
G
--
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
A
G
Y
Y
R
K
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
M
P
Y
P
S
K
S
N
Q
E
V
L
E
F
V
T
S
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
---
R
I
E
Y
C
T
Q
D
P
D
V
I
N
T
A
L
P
I
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
87.79
99%
-99
- C1 -
4FNZ
1
A:
[10-319]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
P
N
Y
S
F
A
G
K
T
S
S
I
S
D
L
K
-------
E
V
P
R
K
N
I
T
L
I
R
G
L
G
H
---
G
E
V
Y
E
G
Q
-
V
S
G
-------
S
-
P
L
-
Q
---
V
A
V
K
T
L
--
P
E
V
C
S
E
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
-
N
H
Q
N
I
V
R
C
I
G
V
S
L
Q
S
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
P
-------
R
----
P
------
S
--------
Q
--
P
S
-
S
----
L
A
---
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
C
P
G
P
G
--
R
V
A
K
I
G
D
F
---------------
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
M
P
Y
P
S
K
S
N
Q
E
V
L
E
F
V
T
S
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
---
R
I
E
Y
C
T
Q
D
P
D
V
I
N
T
A
L
P
I
E
Y
G
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
87.72
99%
-102
- C1 -
4FOB
1
A:
[36-345]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
P
N
Y
S
F
A
G
K
T
S
S
I
S
D
L
K
-------
E
V
P
R
K
N
I
T
L
I
R
G
L
G
H
G
A
F
G
E
V
Y
E
G
Q
-
V
S
--------
S
-
P
L
-
Q
---
V
A
V
K
T
L
--
P
E
V
C
S
E
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
-
N
H
Q
N
I
V
R
C
I
G
V
S
L
Q
S
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
P
-------
R
----
P
------
S
--------------
S
----
L
A
---
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
C
P
G
P
G
--
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
A
------
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
M
P
Y
P
S
K
S
N
Q
E
V
L
E
F
V
T
S
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
---
R
I
E
Y
C
T
Q
D
P
D
V
I
N
T
A
L
P
I
E
Y
G
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
86.16
99%
-104
- C1 -
4FNY
1
A:
[20-321]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
S
I
S
D
L
K
-------
E
V
P
R
K
N
I
T
L
I
R
G
L
G
H
---
G
E
V
Y
E
G
Q
-
V
S
G
---------
P
L
-
Q
---
V
A
V
K
T
L
--
P
E
V
C
S
E
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
-
N
H
Q
N
I
V
R
C
I
G
V
S
L
Q
S
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
P
-------
R
----
P
------
S
-------------------
L
A
---
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
C
P
G
P
G
--
R
V
A
K
I
G
D
F
----------------
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
M
P
Y
P
S
K
S
N
Q
E
V
L
E
F
V
T
S
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
---
R
I
E
Y
C
T
Q
D
P
D
V
I
N
T
A
L
P
I
E
Y
G
P
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
65
PsiBlast_CBE
65.27
40%
-85
- C1 -
4AOJ
1
C:
[33-322]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
C
V
H
-------
H
I
K
R
R
D
I
V
L
K
W
E
L
G
E
G
A
F
G
K
V
F
L
A
E
-
C
H
N
L
L
P
---
Q
D
-
K
M
-
L
---
V
A
V
K
A
L
--
K
E
-
A
S
E
S
A
R
Q
D
F
Q
R
E
A
E
L
L
T
M
L
-
Q
H
Q
H
I
V
R
F
F
G
V
C
T
E
G
R
P
L
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
R
S
H
G
P
-------
D
------------------------
G
-
P
----
L
G
---
L
G
Q
L
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
---
G
Q
G
--
L
V
V
K
I
G
D
F
G
M
----------------
M
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
Y
G
K
Q
P
W
Y
Q
L
S
N
T
E
A
I
D
C
I
T
Q
G
R
E
L
E
R
P
R
A
C
P
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
H
A
---
R
L
Q
A
L
A
Q
A
P
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
67
PsiBlast_CBE
64.83
40%
-89
- C1 -
4AOJ
1
NTRK1_HUMAN
A:
[33-322]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
C
V
H
-------
H
I
K
R
R
D
I
V
L
K
W
E
L
G
E
G
A
F
G
K
V
F
L
A
E
-
C
H
N
L
L
P
------
K
M
-
L
---
V
A
V
K
A
L
--
K
E
-
A
S
E
S
A
R
Q
D
F
Q
R
E
A
E
L
L
T
M
L
-
Q
H
Q
H
I
V
R
F
F
G
V
C
T
E
G
R
P
L
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
R
S
H
G
P
-------
D
-----------------------
P
G
-
P
----
L
G
---
L
G
Q
L
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
---
G
Q
G
--
L
V
V
K
I
G
D
F
G
----------------
T
M
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
Y
G
K
Q
P
W
Y
Q
L
S
N
T
E
A
I
D
C
I
T
Q
G
R
E
L
E
R
P
R
A
C
P
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
H
A
---
R
L
Q
A
L
A
Q
A
P
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
55
PsiBlast_CBE
64.78
43%
-75
- C1 -
3ETA
1
INSR_HUMAN
A:
[12-305]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
S
R
E
K
I
T
L
L
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
N
-
A
R
D
I
I
K
G
--
E
A
-
E
T
-
R
---
V
A
V
K
T
V
--
N
E
S
A
S
L
R
E
R
I
E
F
L
N
E
A
S
V
M
K
G
F
-
T
C
H
H
V
V
R
L
L
G
V
V
S
K
G
Q
P
T
L
V
V
M
E
L
M
A
H
G
D
L
K
S
Y
L
R
S
L
R
P
-------
E
AENN
P
------
G
--------
R
--
P
P
-
P
-----
T
---
L
Q
E
M
I
Q
M
A
A
E
I
A
D
G
M
A
Y
L
N
A
K
K
F
V
H
R
D
L
A
A
R
N
C
M
V
---
A
H
D
--
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
T
D
Y
Y
R
K
G
-
K
G
L
L
P
V
R
W
M
A
P
E
S
L
K
D
G
V
F
T
T
S
S
D
M
W
S
F
G
V
V
L
W
E
I
T
S
L
A
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
K
F
V
M
D
G
G
Y
L
D
Q
P
D
N
C
P
E
R
V
T
D
L
M
R
M
C
W
Q
F
N
P
K
M
R
P
T
F
L
E
I
V
N
---
L
L
K
------
D
D
L
H
P
S
F
P
-
E
V
S
F
F
H
S
E
E
N
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
51
PsiBlast_CBE
64.34
45%
-83
- C1 -
3LW0
2
IGF1R_HUMAN
A:
[6-285]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
P
D
E
W
-------
E
V
A
R
E
K
I
T
M
S
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
V
-
A
K
G
V
V
K
D
--
E
P
-
E
T
-
R
---
V
A
I
K
T
V
--
N
E
A
A
S
M
R
E
R
I
E
F
L
N
E
A
S
V
M
K
E
F
-
N
C
H
H
V
V
R
L
L
G
V
V
S
Q
G
Q
P
T
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
L
R
P
-----------------------------------------PPS
L
S
K
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
---
A
E
D
--
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
T
D
Y
Y
R
K
G
---
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
A
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
R
F
V
M
E
G
G
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
I
S
---
S
I
K
E
E
M
E
P
G
F
R
E
V
S
F
Y
Y
S
E
E
N
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
66
PsiBlast_CBE
63.95
40%
-85
- C1 -
4AOJ
1
NTRK1_HUMAN
B:
[33-324]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
C
V
H
-------
H
I
K
R
R
D
I
V
L
K
W
E
L
G
E
G
A
F
G
K
V
F
L
A
E
-
C
H
N
L
L
P
------
K
M
-
L
---
V
A
V
K
A
L
--
K
E
-
A
S
E
S
A
R
Q
D
F
Q
R
E
A
E
L
L
T
M
L
-
Q
H
Q
H
I
V
R
F
F
G
V
C
T
E
G
R
P
L
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
R
S
H
G
P
-------
D
------------------------
G
-
P
----
L
G
---
L
G
Q
L
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
---
G
Q
G
--
L
V
V
K
I
G
D
F
-------------------
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
Y
G
K
Q
P
W
Y
Q
L
S
N
T
E
A
I
D
C
I
T
Q
G
R
E
L
E
R
P
R
A
C
P
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
H
A
---
R
L
Q
A
L
A
Q
A
P
P
V
Y
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
69
PsiBlast_CBE
63.85
40%
-87
- C1 -
4YNE
2
A:
[4-300]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
S
G
I
R
V
H
-------
H
I
K
R
R
D
I
V
L
K
W
E
L
G
E
G
A
F
G
K
V
F
L
A
E
-
C
H
N
L
L
P
----
D
-
K
M
-
L
---
V
A
V
K
A
L
--
K
E
------
R
Q
D
F
Q
R
E
A
E
L
L
T
M
L
-
Q
H
Q
H
I
V
R
F
F
G
V
C
T
E
G
R
P
L
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
R
S
H
G
P
-------
D
----
A
------
K
L
L
A
G
G
EDV
A
--
P
G
-
P
----
L
G
---
L
G
Q
L
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
---
G
Q
G
--
L
V
V
K
I
G
D
F
G
M
S
-----
T
D
Y
Y
----
R
T
M
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
Y
G
K
Q
P
W
Y
Q
L
S
N
T
E
A
I
D
C
I
T
Q
G
R
E
L
E
R
P
R
A
C
P
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
H
A
---
R
L
Q
A
L
A
Q
A
P
P
V
Y
L
D
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
50
PsiBlast_CBE
63.76
45%
-83
- C1 -
3LW0
3
IGF1R_HUMAN
B:
[6-285]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
P
D
E
W
-------
E
V
A
R
E
K
I
T
M
S
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
V
-
A
K
G
V
V
K
D
--
E
P
-
E
T
-
R
---
V
A
I
K
T
V
--
N
E
A
A
S
M
R
E
R
I
E
F
L
N
E
A
S
V
M
K
E
F
-
N
C
H
H
V
V
R
L
L
G
V
V
S
Q
G
Q
P
T
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
L
R
P
-----------------------------------------PPS
L
S
K
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
---
A
E
D
--
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
T
D
Y
Y
R
K
G
---
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
A
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
R
F
V
M
E
G
G
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
I
S
---
S
I
K
E
E
M
E
P
G
F
R
E
V
S
F
Y
Y
S
E
E
N
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
38
PsiBlast_CBE
63.50
44%
-80
- C1 -
1JQH
1
IGF1R_HUMAN
B:
[6-289]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
V
Y
V
P
D
E
W
-------
E
V
A
R
E
K
I
T
M
S
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
V
-
A
K
G
V
V
K
D
--
E
P
-
E
T
-
R
---
V
A
I
K
T
V
--
N
E
A
A
S
M
R
E
R
I
E
F
L
N
E
A
S
V
M
K
E
F
-
N
C
H
H
V
V
R
L
L
G
V
V
S
Q
G
Q
P
T
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
L
R
P
-----------------------------------------PPS
L
S
K
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
---
A
E
D
--
F
T
V
K
I
G
D
F
G
M
T
-------
Y
Y
R
K
G
G
K
G
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
A
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
R
F
V
M
E
G
G
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
I
S
---
S
I
K
E
E
M
E
P
G
F
R
E
V
S
F
Y
Y
S
E
E
N
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
48
PsiBlast_CBE
63.38
45%
-83
- C1 -
3LW0
2
D:
[6-285]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
P
D
E
W
-------
E
V
A
R
E
K
I
T
M
S
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
V
-
A
K
G
V
V
K
D
--
E
P
-
E
T
-
R
---
V
A
I
K
T
V
--
N
E
A
A
S
M
R
E
R
I
E
F
L
N
E
A
S
V
M
K
E
F
-
N
C
H
H
V
V
R
L
L
G
V
V
S
Q
G
Q
P
T
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
L
R
P
-----------------------------------------PPS
L
S
K
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
---
A
E
D
--
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
T
D
Y
Y
R
K
G
---
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
A
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
R
F
V
M
E
G
G
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
I
S
---
S
I
K
E
E
M
E
P
G
F
R
E
V
S
F
Y
Y
S
E
E
N
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
54
PsiBlast_CBE
63.20
43%
-75
- C1 -
3ETA
1
B:
[12-305]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
S
R
E
K
I
T
L
L
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
N
-
A
R
D
I
I
K
G
--
E
A
-
E
T
-
R
---
V
A
V
K
T
V
--
N
E
S
A
S
L
R
E
R
I
E
F
L
N
E
A
S
V
M
K
G
F
-
T
C
H
H
V
V
R
L
L
G
V
V
S
K
G
Q
P
T
L
V
V
M
E
L
M
A
H
G
D
L
K
S
Y
L
R
S
L
R
P
-------
E
AENN
P
------
G
--------
R
--
P
P
-
P
-----
T
---
L
Q
E
M
I
Q
M
A
A
E
I
A
D
G
M
A
Y
L
N
A
K
K
F
V
H
R
D
L
A
A
R
N
C
M
V
---
A
H
D
--
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
T
D
Y
Y
R
K
--
K
G
L
L
P
V
R
W
M
A
P
E
S
L
K
D
G
V
F
T
T
S
S
D
M
W
S
F
G
V
V
L
W
E
I
T
S
L
A
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
K
F
V
M
D
G
G
Y
L
D
Q
P
D
N
C
P
E
R
V
T
D
L
M
R
M
C
W
Q
F
N
P
K
M
R
P
T
F
L
E
I
V
N
---
L
L
K
------
D
D
L
H
P
S
F
P
-
E
V
S
F
F
H
S
E
E
N
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
43
PsiBlast_CBE
63.20
45%
-81
- C1 -
3NW7
1
A:
[9-288]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
P
D
E
W
-------
E
V
A
R
E
K
I
T
M
S
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
V
-
A
K
G
V
V
K
D
--
E
P
-
E
T
-
R
---
V
A
I
K
T
V
--
N
E
A
A
S
M
R
E
R
I
E
F
L
N
E
A
S
V
M
K
E
F
-
N
C
H
H
V
V
R
L
L
G
V
V
S
Q
G
Q
P
T
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
L
R
P
-------
E
----
M
------
E
--------
N
--
N
P
-
V
----
L
A
PPS
L
S
K
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
---
A
E
D
--
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
T
D
Y
Y
R
K
G
---
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
A
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
R
F
V
M
E
G
G
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
I
S
---
S
I
K
E
E
M
E
P
G
F
R
E
V
S
F
Y
Y
S
E
E
N
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
68
PsiBlast_CBE
62.88
40%
-80
- C1 -
4YPS
1
A:
[4-297]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
S
G
I
R
V
H
-------
H
I
K
R
R
D
I
V
L
K
W
E
L
G
E
---
G
K
V
F
L
A
E
-
C
H
N
L
L
-----
D
-
K
M
-
L
---
V
A
V
K
A
L
------
S
E
S
A
R
Q
D
F
Q
R
E
A
E
L
L
T
M
L
-
Q
H
Q
H
I
V
R
F
F
G
V
C
T
E
G
R
P
L
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
R
S
H
G
P
-------
D
----
A
------
K
L
L
A
G
G
EDV
A
--
P
G
-
P
----
L
G
---
L
G
Q
L
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
---
G
Q
G
--
L
V
V
K
I
G
D
--
M
S
R
D
I
Y
S
T
D
Y
Y
R
V
---
T
M
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
Y
G
K
Q
P
W
Y
Q
L
S
N
T
E
A
I
D
C
I
T
Q
G
R
E
L
E
R
P
R
A
C
P
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
H
A
---
R
L
Q
A
L
A
Q
A
P
P
V
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
44
PsiBlast_CBE
62.49
45%
-83
- C1 -
3NW6
1
A:
[9-288]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
P
D
E
W
-------
E
V
A
R
E
K
I
T
M
S
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
V
-
A
K
G
V
V
K
D
--
E
P
-
E
T
-
R
---
V
A
I
K
T
V
--
N
E
A
A
S
M
R
E
R
I
E
F
L
N
E
A
S
V
M
K
E
F
-
N
C
H
H
V
V
R
L
L
G
V
V
S
Q
G
Q
P
T
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
L
R
P
-------
E
----
M
------
E
--------
N
--
N
P
-
V
----
L
A
PPS
L
S
K
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
---
A
E
D
--
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
T
D
Y
Y
R
K
G
G
K
G
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
A
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
R
F
V
M
E
G
G
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
I
S
---
S
I
K
E
E
M
E
P
G
F
R
E
V
S
F
Y
Y
S
E
E
N
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
49
PsiBlast_CBE
62.41
45%
-82
- C1 -
3LW0
3
IGF1R_HUMAN
C:
[6-285]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
P
D
E
W
-------
E
V
A
R
E
K
I
T
M
S
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
V
-
A
K
G
V
V
K
D
--
E
P
-
E
T
-
R
---
V
A
I
K
T
V
--
N
E
A
A
S
M
R
E
R
I
E
F
L
N
E
A
S
V
M
K
E
F
-
N
C
H
H
V
V
R
L
L
G
V
V
S
Q
G
Q
P
T
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
L
R
P
-----------------------------------------PPS
L
S
K
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
---
A
E
D
--
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
T
D
Y
Y
R
K
G
---
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
A
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
R
F
V
M
E
G
G
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
I
S
---
S
I
K
E
E
M
E
P
G
F
R
E
V
S
F
Y
Y
S
E
E
N
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
45
PsiBlast_CBE
62.24
45%
-85
- C1 -
3NW5
1
A:
[9-288]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
P
D
E
W
-------
E
V
A
R
E
K
I
T
M
S
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
V
-
A
K
G
V
V
K
D
--
E
P
-
E
T
-
R
---
V
A
I
K
T
V
--
N
E
A
A
S
M
R
E
R
I
E
F
L
N
E
A
S
V
M
K
E
F
-
N
C
H
H
V
V
R
L
L
G
V
V
S
Q
G
Q
P
T
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
L
R
P
-------
E
----
M
------
E
--------
N
--
N
P
-
V
----
L
A
PPS
L
S
K
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
---
A
E
D
--
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
T
D
Y
Y
R
K
G
G
K
G
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
A
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
R
F
V
M
E
G
G
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
I
S
---
S
I
K
E
E
M
E
P
G
F
R
E
V
S
F
Y
Y
S
E
E
N
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
71
PsiBlast_CBE
61.81
41%
-86
- C1 -
4PMP
1
A:
[2-286]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
H
-------
H
I
K
R
R
D
I
V
L
K
W
E
L
G
E
G
A
F
G
K
V
F
L
A
E
-
C
H
N
L
L
-------
K
M
-
L
---
V
A
V
K
A
L
--
K
-----
S
A
R
Q
D
F
Q
R
E
A
E
L
L
T
M
L
-
Q
H
Q
H
I
V
R
F
F
G
V
C
T
E
G
R
P
L
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
R
S
H
G
P
-------
D
----
A
------
K
LLAGGEDV
A
--
P
G
-
P
----
L
G
---
L
G
Q
L
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
---
G
Q
G
--
L
V
V
K
I
G
D
F
G
M
S
R
-
I
Y
S
T
D
Y
Y
R
V
G
--
T
M
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
Y
G
K
Q
P
W
Y
Q
L
S
N
T
E
A
I
D
C
I
T
Q
G
R
E
L
E
R
P
R
A
C
P
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
H
A
---
R
L
Q
A
L
A
Q
A
H
H
H
H
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
53
PsiBlast_CBE
61.67
45%
-81
- C1 -
4D2R
1
A:
[4-283]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
P
D
E
W
-------
E
V
A
R
E
K
I
T
M
S
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
V
-
A
K
G
V
V
K
D
--
E
P
-
E
T
-
R
---
V
A
I
K
T
V
--
N
E
A
A
S
M
R
E
R
I
E
F
L
N
E
A
S
V
M
K
E
F
-
N
C
H
H
V
V
R
L
L
G
V
V
S
Q
G
Q
P
T
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
L
R
P
-------
E
----
M
------
E
--------
N
--
N
P
-
V
----
L
A
PPS
L
S
K
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
---
A
E
D
--
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
T
D
Y
Y
R
K
--
K
G
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
A
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
R
F
V
M
E
G
G
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
I
S
---
S
I
K
E
E
M
E
P
G
F
R
E
V
S
F
Y
Y
S
E
E
N
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
46
PsiBlast_CBE
61.45
45%
-80
- C1 -
2OJ9
1
A:
[9-288]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
P
D
E
W
-------
E
V
A
R
E
K
I
T
M
S
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
V
-
A
K
G
V
V
K
D
--
E
P
-
E
T
-
R
---
V
A
I
K
T
V
--
N
E
A
A
S
M
R
E
R
I
E
F
L
N
E
A
S
V
M
K
E
F
-
N
C
H
H
V
V
R
L
L
G
V
V
S
Q
G
Q
P
T
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
L
R
P
-------
E
---------------------------------PPS
L
S
K
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
---
A
E
D
--
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
T
D
Y
Y
R
K
G
G
K
G
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
A
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
R
F
V
M
E
G
G
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
I
S
---
S
I
K
E
E
M
E
P
G
F
R
E
V
S
F
Y
Y
S
E
E
N
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
47
PsiBlast_CBE
61.12
45%
-85
- C1 -
3I81
1
A:
[9-288]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
P
D
E
W
-------
E
V
A
R
E
K
I
T
M
S
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
V
-
A
K
G
V
V
K
D
--
E
P
-
E
T
-
R
---
V
A
I
K
T
V
--
N
E
A
A
S
M
R
E
R
I
E
F
L
N
E
A
S
V
M
K
E
F
-
N
C
H
H
V
V
R
L
L
G
V
V
S
Q
G
Q
P
T
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
L
R
P
-------
E
-----------
E
--------
N
--
N
P
-
V
----
L
A
PPS
L
S
K
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
---
A
E
D
--
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
T
D
Y
Y
R
-----
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
A
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
R
F
V
M
E
G
G
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
I
S
---
S
I
K
E
E
M
E
P
G
F
R
E
V
S
F
Y
Y
S
E
E
N
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
37
PsiBlast_CBE
60.67
43%
-88
- C1 -
3LVP
2
IGF1R_HUMAN
A:
[39-317]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
D
E
W
-------
E
V
A
R
E
K
I
T
M
S
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
V
-
A
K
G
V
V
K
D
--
E
P
-
E
T
-
R
---
V
A
I
K
T
V
--
N
E
A
A
S
M
R
E
R
I
E
F
L
N
E
A
S
V
M
K
E
F
-
N
C
H
H
V
V
R
L
L
G
V
V
S
Q
G
Q
P
T
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
L
R
P
-------
E
----
M
------
E
------------
P
-
V
----
L
A
PPS
L
S
K
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
---
A
E
D
--
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
-------
G
G
K
G
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
A
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
R
F
V
M
E
G
G
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
I
S
---
S
I
K
E
E
M
E
P
G
F
R
E
V
S
F
Y
Y
S
E
E
N
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
41
PsiBlast_CBE
60.57
45%
-80
- C1 -
3QQU
1
IGF1R_HUMAN
B:
[3-282]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
P
D
E
W
-------
E
V
A
R
E
K
I
T
M
S
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
V
-
A
K
G
V
V
K
D
--
E
P
-
E
T
-
R
---
V
A
I
K
T
V
--
N
E
A
A
S
M
R
E
R
I
E
F
L
N
E
A
S
V
M
K
E
F
-
N
C
H
H
V
V
R
L
L
G
V
V
S
Q
G
Q
P
T
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
L
R
------------------------------------------PS-
L
S
K
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
---
A
E
D
--
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
T
D
Y
Y
R
K
G
G
K
G
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
A
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
R
F
V
M
E
G
G
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
I
S
---
S
I
K
E
E
M
E
P
G
F
R
E
V
S
F
Y
Y
S
E
E
N
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
36
PsiBlast_CBE
60.23
49%
-91
- C1 -
3ZBF
1
A:
[24-306]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
E
N
L
P
-------
A
F
P
R
E
K
L
T
L
R
L
L
L
G
S
---
G
E
V
Y
E
G
T
A
V
D
I
L
G
V
G
--
S
G
-
E
I
-
K
---
V
A
V
K
T
L
--
K
K
G
S
T
D
Q
E
K
I
E
F
L
K
E
A
H
L
M
S
K
F
-
N
H
P
N
I
L
K
Q
L
G
V
C
L
L
N
E
P
Q
Y
I
I
L
E
L
M
E
G
G
D
L
L
T
Y
L
R
K
A
R
M
-------
A
----
T
------
F
--------
Y
--
G
P
-
L
----
L
T
---
L
V
D
L
V
D
L
C
V
D
I
S
K
G
C
V
Y
L
E
R
M
H
F
I
H
R
D
L
A
A
R
N
C
L
V
S
V
K
D
Y
T
S
P
R
I
V
K
I
G
D
F
G
L
A
R
D
I
Y
------------
L
P
V
R
W
M
A
P
E
S
L
M
D
G
I
F
T
T
Q
S
D
V
W
S
F
G
I
L
I
W
E
I
L
T
L
G
H
Q
P
Y
P
A
H
S
N
L
D
V
L
N
Y
V
Q
T
G
G
R
L
E
P
P
R
N
C
P
D
D
L
W
N
L
M
T
Q
C
W
A
Q
E
P
D
Q
R
P
T
F
H
R
I
Q
D
---
Q
L
Q
L
F
R
N
F
F
L
N
S
I
Y
K
S
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
90
PsiBlast_CBE
60.22
39%
-89
- C1 -
4RWK
1
B:
[24-307]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
-
A
I
G
L
D
K
D
K-
P
N
-
R
V
T
K
---
V
A
V
K
M
L
--
K
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
M
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
-----------------------------------
Q
----
L
S
---
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
--
N
V
M
K
I
A
D
F
G
L
A
-----
I
D
Y
Y
K
K
T
--
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
V
P
V
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
---
D
L
D
R
I
V
A
L
T
S
N
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
56
PsiBlast_CBE
60.12
45%
-79
- C1 -
1I44
1
A:
[9-283]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
D
E
W
-------
E
V
S
R
E
K
I
T
L
L
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
N
-
A
R
D
I
I
K
G
--
E
A
-
E
T
-
R
---
V
A
V
K
T
V
--
N
E
S
A
S
L
R
E
R
I
E
F
L
N
E
A
S
V
M
K
G
F
-
T
C
H
H
V
V
R
L
L
G
V
V
S
K
G
Q
P
T
L
V
V
M
E
L
M
A
H
G
D
L
K
S
Y
L
R
S
L
R
P
-------
E
AENN
P
------
G
--------
R
--
P
P
-
P
-----
T
---
L
Q
E
M
I
Q
M
A
A
E
I
A
D
G
M
A
Y
L
N
A
K
K
F
V
H
R
D
L
A
A
R
N
C
M
V
---
A
H
D
--
F
T
V
K
I
G
D
F
G
M
T
----------------
L
P
V
R
W
M
A
P
E
S
L
K
D
G
V
F
T
T
S
S
D
M
W
S
F
G
V
V
L
W
E
I
T
S
L
A
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
K
F
V
M
D
G
G
Y
L
D
Q
P
D
N
C
P
E
R
V
T
D
L
M
R
M
C
W
Q
F
N
P
K
M
R
P
T
F
L
E
I
V
N
---
L
L
K
D
D
L
H
P
S
F
P
E
V
S
F
F
H
S
E
E
N
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
70
PsiBlast_CBE
60.04
41%
-84
- C1 -
4PMT
1
A:
[2-286]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
H
-------
H
I
K
R
R
D
I
V
L
K
W
E
L
G
E
G
A
F
G
K
V
F
L
A
E
-
C
H
N
L
------
D
-
K
M
-
L
---
V
A
V
K
A
L
------------
D
F
Q
R
E
A
E
L
L
T
M
L
-
Q
H
Q
H
I
V
R
F
F
G
V
C
T
E
G
R
P
L
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
R
S
H
G
P
-------
D
----
A
------
K
LLAGGEDV
A
--
P
G
-
P
----
L
G
---
L
G
Q
L
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
---
G
Q
G
--
L
V
V
K
I
G
D
F
--
S
R
D
I
Y
S
T
D
Y
Y
R
V
---
T
M
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
Y
G
K
Q
P
W
Y
Q
L
S
N
T
E
A
I
D
C
I
T
Q
G
R
E
L
E
R
P
R
A
C
P
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
H
A
---
R
L
Q
A
L
A
Q
A
H
H
H
H
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
101
PsiBlast_CBE
60.00
39%
-85
- C1 -
4RWJ
1
B:
[24-307]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
-
A
I
G
L
D
K
D
K-
P
N
-
R
V
T
K
---
V
A
V
K
M
L
--
K
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
P
PG--------------------------------
Q
----
L
S
---
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
--
N
V
M
K
I
A
D
F
G
L
---------
Y
K
K
T
T
-
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
V
P
V
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
---
D
L
D
R
I
V
A
L
T
S
N
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
106
PsiBlast_CBE
59.89
39%
-85
- C1 -
3JS2
1
FGFR1_HUMAN
A:
[24-307]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
-
A
I
G
L
D
K
D
K-
P
N
-
R
V
T
K
---
V
A
V
K
M
L
--
K
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
P
PGL-------------------------
H
NP
E
E
-
Q
----
L
S
---
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
--
N
V
M
K
I
A
D
F
G
L
A
R
D
I
H
H
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
V
P
V
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
---
D
L
D
R
I
V
A
L
T
S
N
Q
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
79
PsiBlast_CBE
59.88
39%
-91
- C1 -
4K33
1
A:
[32-315]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
S
R
A
R
L
T
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
M
A
E
-
A
I
G
I
D
K
D
RA
A
K
-
P
V
-
T
---
V
A
V
K
M
L
--
K
D
D
A
T
D
K
D
L
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
G
G
P
L
Y
V
L
V
E
Y
A
A
K
G
N
L
R
E
F
L
R
A
R
R
P
PGLDYSF
D
----
T
------
S
------------
E
-
Q
----
L
T
---
F
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
--
N
V
M
K
I
A
D
F
G
L
A
R
D
V
H
N
L
D
Y
Y
K
E
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
I
P
V
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
A
N
C
T
H
D
L
Y
M
I
M
R
E
C
W
H
A
A
P
S
Q
R
P
T
F
K
Q
L
V
E
---
D
L
D
R
V
L
T
V
T
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
42
PsiBlast_CBE
59.65
45%
-83
- C1 -
3QQU
1
IGF1R_HUMAN
A:
[6-282]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
W
-------
E
V
A
R
E
K
I
T
M
S
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
V
-
A
K
G
V
V
K
D
--
E
P
-
E
T
-
R
---
V
A
I
K
T
V
--
N
E
A
A
S
M
R
E
R
I
E
F
L
N
E
A
S
V
M
K
E
F
-
N
C
H
H
V
V
R
L
L
G
V
V
S
Q
G
Q
P
T
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
L
R
------------------------------------------PPS
L
S
K
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
---
A
E
D
--
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
T
D
Y
Y
R
K
G
G
K
G
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
A
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
R
F
V
M
E
G
G
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
I
S
---
S
I
K
E
E
M
E
P
G
F
R
E
V
S
F
Y
Y
S
E
E
N
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
77
PsiBlast_CBE
59.57
42%
-88
- C1 -
3CBL
3
A:
[114-370]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
L
V
L
G
E
Q
I
G
R
G
N
F
G
E
V
F
S
G
R
-
L
R
A
-------
D
-
N
T
-
L
---
V
A
V
K
S
C
--
R
E
T
L
P
P
D
L
K
A
K
F
L
Q
E
A
R
I
L
K
Q
Y
-
S
H
P
N
I
V
R
L
I
G
V
C
T
Q
K
Q
P
I
Y
I
V
M
E
L
V
Q
G
G
D
F
L
T
F
L
R
-----------------------
T
--------
E
--
G
A
-
R
----
L
R
---
V
K
T
L
L
Q
M
V
G
D
A
A
A
G
M
E
Y
L
E
S
K
C
C
I
H
R
D
L
A
A
R
N
C
L
V
T
---
E
K
--
N
V
L
K
I
S
D
F
G
M
S
R
E
E
A
D
G
V
Y
A
A
S
G
G
L
R
Q
V
P
V
K
W
T
A
P
E
A
L
N
Y
G
R
Y
S
S
E
S
D
V
W
S
F
G
I
L
L
W
E
T
F
S
L
G
A
S
P
Y
P
N
L
S
N
Q
Q
T
R
E
F
V
E
K
G
G
R
L
P
C
P
E
L
C
P
D
A
V
F
R
L
M
E
Q
C
W
A
Y
E
P
G
Q
R
P
S
F
S
T
I
Y
Q
---
E
L
Q
S
I
R
K
R
H
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
40
PsiBlast_CBE
59.53
45%
-79
- C1 -
3QQU
1
IGF1R_HUMAN
C:
[4-282]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
D
E
W
-------
E
V
A
R
E
K
I
T
M
S
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
V
-
A
K
G
V
V
K
D
--
E
P
-
E
T
-
R
---
V
A
I
K
T
V
--
N
E
A
A
S
M
R
E
R
I
E
F
L
N
E
A
S
V
M
K
E
F
-
N
C
H
H
V
V
R
L
L
G
V
V
S
Q
G
Q
P
T
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
L
R
P
-------
E
----
M
---------------------
V
----
L
A
PPS
L
S
K
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
---
A
E
D
--
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
T
D
Y
Y
R
K
G
G
K
G
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
A
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
R
F
V
M
E
G
G
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
I
S
---
S
I
K
E
E
M
E
P
G
F
R
E
V
S
F
Y
Y
S
E
E
N
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
35
PsiBlast_CBE
59.48
49%
-91
- C1 -
4UXL
1
A:
[24-306]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
E
N
L
P
-------
A
F
P
R
E
K
L
T
L
R
L
L
L
G
S
G
A
F
G
E
V
Y
E
G
T
A
V
D
I
L
G
V
G
--
S
G
-
E
I
-
K
---
V
A
V
K
T
L
--
K
K
G
S
T
D
Q
E
K
I
E
F
L
K
E
A
H
L
M
S
K
F
-
N
H
P
N
I
L
K
Q
L
G
V
C
L
L
N
E
P
Q
Y
I
I
L
E
L
M
E
G
G
D
L
L
T
Y
L
R
K
A
R
M
-------
A
----
T
------
F
--------
Y
--
G
P
-
L
----
L
T
---
L
V
D
L
V
D
L
C
V
D
I
S
K
G
C
V
Y
L
E
R
M
H
F
I
H
R
D
L
A
A
R
N
C
L
V
S
V
K
D
Y
T
S
P
R
I
V
K
I
G
D
F
G
L
A
R
D
I
Y
K
--------
E
G
L
L
P
V
R
W
M
A
P
E
S
L
M
D
G
I
F
T
T
Q
S
D
V
W
S
F
G
I
L
I
W
E
I
L
T
L
G
H
Q
P
Y
P
A
H
S
N
L
D
V
L
N
Y
V
Q
T
G
G
R
L
E
P
P
R
N
C
P
D
D
L
W
N
L
M
T
Q
C
W
A
Q
E
P
D
Q
R
P
T
F
H
R
I
Q
D
---
Q
L
Q
L
F
R
N
F
F
L
N
S
I
Y
K
S
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
98
PsiBlast_CBE
59.42
39%
-88
- C1 -
5A4C
7
?
B:
[14-297]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
-
A
I
G
L
D
----
P
N
-
R
V
T
K
---
V
A
V
K
M
L
--
K
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
P
P-------------------------------
E
-
Q
----
L
S
---
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
--
N
V
M
K
I
A
D
F
G
L
A
-----
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
V
P
V
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
---
D
L
D
R
I
V
A
L
T
S
N
Q
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
81
PsiBlast_CBE
59.25
38%
-79
- C1 -
3GQL
1
FGFR1_HUMAN
B:
[24-317]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
-
A
I
G
L
D
K
D
K-
P
N
-
R
V
T
K
---
V
A
V
K
M
L
--
K
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
P
P----------------------------P-
E
E
-
Q
----
L
S
---
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
--
N
V
M
K
I
A
D
F
G
L
A
R
----------------
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
V
P
V
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
A
L
T
S
N
Q
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
39
PsiBlast_CBE
59.25
45%
-85
- C1 -
3QQU
1
D:
[4-282]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
D
E
W
-------
E
V
A
R
E
K
I
T
M
S
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
V
-
A
K
G
V
V
K
D
--
E
P
-
E
T
-
R
---
V
A
I
K
T
V
--
N
E
A
A
S
M
R
E
R
I
E
F
L
N
E
A
S
V
M
K
E
F
-
N
C
H
H
V
V
R
L
L
G
V
V
S
Q
G
Q
P
T
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
L
R
P
-------
E
----
M
--------------------------
L
A
PPS
L
S
K
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
---
A
E
D
--
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
T
D
Y
Y
R
K
G
G
K
G
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
A
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
R
F
V
M
E
G
G
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
I
S
---
S
I
K
E
E
M
E
P
G
F
R
E
V
S
F
Y
Y
S
E
E
N
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
95
PsiBlast_CBE
59.13
39%
-85
- C1 -
4WUN
1
FGFR1_HUMAN
A:
[18-301]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
-
A
I
G
L
D
K
D
K-
P
N
-
R
V
T
K
---
V
A
V
K
M
L
--
K
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
P
PLEYSY-
N
----
P
------
S
--------
H
NP
E
E
-
Q
----
L
S
---
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
--
N
V
M
K
I
A
D
F
G
------------------
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
V
P
V
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
---
D
L
D
R
I
V
A
L
T
S
N
Q
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
99
PsiBlast_CBE
59.11
39%
-86
- C1 -
5A4C
6
?
A:
[14-297]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
--
F
G
Q
V
V
L
A
E
-
A
I
G
L
D
K
D
K-
P
N
-
R
V
T
K
---
V
A
V
K
M
L
--
K
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
P
PGLEYSY
N
----
P
------
S
--------
H
NP
E
E
-
Q
----
L
S
---
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
--
N
V
M
K
I
A
D
F
G
L
------
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
V
P
V
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
---
D
L
D
R
I
V
A
L
T
S
N
Q
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
80
PsiBlast_CBE
59.01
38%
-91
- C1 -
3GQL
1
C:
[24-318]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
-
A
I
G
L
D
K
D
K-
P
N
-
R
V
T
K
---
V
A
V
K
M
L
--
K
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
P
P-------------------------------
E
-
Q
----
L
S
---
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
--
N
V
M
K
I
A
D
F
G
L
A
R
----------------
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
V
P
V
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
A
L
T
S
N
Q
E
Y
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
105
PsiBlast_CBE
58.53
39%
-82
- C1 -
3JS2
1
B:
[24-307]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
-
A
I
G
L
D
K
D
K-
P
N
-
R
V
T
K
---
V
A
V
K
M
L
--
K
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
P
P-------------------------------
E
-
Q
----
L
S
---
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
--
N
V
M
K
I
A
D
F
G
L
A
R
D
I
H
H
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
V
P
V
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
---
D
L
D
R
I
V
A
L
T
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
63
PsiBlast_CBE
58.42
42%
-79
- C1 -
4AT4
1
A:
[7-277]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
Q
-------
H
I
K
R
H
N
I
V
L
K
R
E
L
G
E
G
A
F
G
K
V
F
L
A
E
-
C
Y
N
L
C
-------
K
I
-
L
---
V
A
V
K
T
L
--
K
D
-
A
S
D
N
A
R
K
D
F
H
R
E
A
E
L
L
T
N
L
-
Q
H
E
H
I
V
K
F
Y
G
V
C
V
E
G
D
P
L
I
M
V
F
E
Y
M
K
H
G
D
L
N
K
F
L
R
A
H
G
P
-------
D
----
A
V
L
M
A-----------
P
--
P
T
-
E
----
L
T
---
Q
S
Q
M
L
H
I
A
Q
Q
I
A
A
G
M
V
Y
L
A
S
Q
H
F
V
H
R
D
L
A
T
R
N
C
L
V
---
G
E
N
--
L
L
V
K
I
G
D
F
G
M
S
R
D
V
Y
S
T
D
Y
Y
R
V
G
G
H
T
M
L
P
I
R
W
M
P
P
E
S
I
M
Y
R
K
F
T
T
E
S
D
V
W
S
L
G
V
V
L
W
E
I
F
T
Y
G
K
Q
P
W
Y
Q
L
S
N
N
E
V
I
E
C
I
T
Q
G
R
V
L
Q
R
P
R
T
C
P
Q
E
V
Y
E
L
M
L
G
C
W
Q
R
E
P
H
M
R
K
N
I
K
G
I
H
T
---
L
L
Q
N
L
A
K
A
S
P
V
Y
L
D
I
L
G
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
100
PsiBlast_CBE
58.25
39%
-87
- C1 -
4RWL
1
B:
[24-307]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
-
A
I
G
L
D
----
P
N
-
R
V
T
K
---
V
A
V
K
M
L
--
K
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
P
P-------------------------------
E
-
Q
----
L
S
---
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
--
N
V
M
K
I
A
D
F
G
L
------
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
V
P
V
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
---
D
L
D
R
I
V
A
L
T
S
N
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
94
PsiBlast_CBE
57.95
39%
-89
- C1 -
4WUN
1
B:
[18-301]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
-
A
I
G
L
---K-
P
N
-
R
V
T
K
---
V
A
V
K
M
L
--
K
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
P
P---------------------------------
Q
----
L
S
---
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
--
N
V
M
K
I
A
D
F
G
L
-----------------
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
V
P
V
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
---
D
L
D
R
I
V
A
L
T
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
82
PsiBlast_CBE
57.94
38%
-79
- C1 -
3GQL
1
FGFR1_HUMAN
A:
[24-326]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
-
A
I
G
L
D
K
D
K-
P
N
-
R
V
T
K
---
V
A
V
K
M
L
--
K
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
P
P-------------------------------
E
-
Q
----
L
S
---
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
--
N
V
M
K
I
A
D
F
G
L
A
R
------------
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
V
P
V
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
A
L
T
S
N
Q
E
Y
L
D
L
S
M
P
L
D
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
89
PsiBlast_CBE
57.92
40%
-86
- C1 -
4UXQ
1
A:
[15-300]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
W
-------
E
F
P
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
R
A
E
-
A
F
G
M
--
D
--
P
A
R
P
D
-
Q
A
S
T
V
A
V
K
M
L
--
K
D
N
A
S
D
K
D
L
A
D
L
V
S
E
M
E
V
M
K
L
I
G
R
H
K
N
I
I
N
L
L
G
V
C
T
Q
E
G
P
L
Y
V
I
V
E
C
A
A
K
G
N
L
R
E
F
L
R
A
R
R
P
PGP------------------------------------
L
S
---
F
P
V
L
V
S
C
A
Y
Q
V
A
R
G
M
Q
Y
L
E
S
R
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
--
N
V
M
K
I
A
D
F
G
L
A
R
G
V
H
H
I
D
Y
Y
K
K
T
S
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
I
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
I
P
V
E
E
L
F
S
L
L
R
E
G
H
R
M
D
R
P
P
H
C
P
P
E
L
Y
G
L
M
R
E
C
W
H
A
A
P
S
Q
R
P
T
F
K
Q
L
V
E
---
A
L
D
K
V
L
L
A
V
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
62
PsiBlast_CBE
57.66
42%
-78
- C1 -
4AT5
2
A:
[7-277]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
Q
-------
H
I
K
R
H
N
I
V
L
K
R
E
L
G
E
G
A
F
G
K
V
F
L
A
E
-
C
Y
N
L
--------
K
I
-
L
---
V
A
V
K
T
L
--
K
D
-
A
S
D
N
A
R
K
D
F
H
R
E
A
E
L
L
T
N
L
-
Q
H
E
H
I
V
K
F
Y
G
V
C
V
E
G
D
P
L
I
M
V
F
E
Y
M
K
H
G
D
L
N
K
F
L
R
A
H
G
P
-------
D
----
A
V
L
M
AE
G
N
--------
P
--
P
T
-
E
----
L
T
---
Q
S
Q
M
L
H
I
A
Q
Q
I
A
A
G
M
V
Y
L
A
S
Q
H
F
V
H
R
D
L
A
T
R
N
C
L
V
---
G
E
N
--
L
L
V
K
I
G
D
F
G
M
S
R
D
V
Y
S
T
D
Y
Y
R
V
G
G
H
T
M
L
P
I
R
W
M
P
P
E
S
I
M
Y
R
K
F
T
T
E
S
D
V
W
S
L
G
V
V
L
W
E
I
F
T
Y
G
K
Q
P
W
Y
Q
L
S
N
N
E
V
I
E
C
I
T
Q
G
R
V
L
Q
R
P
R
T
C
P
Q
E
V
Y
E
L
M
L
G
C
W
Q
R
E
P
H
M
R
K
N
I
K
G
I
H
T
---
L
L
Q
N
L
A
K
A
S
P
V
Y
L
D
I
L
G
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
64
PsiBlast_CBE
57.62
42%
-77
- C1 -
4AT3
1
A:
[7-277]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
Q
-------
H
I
K
R
H
N
I
V
L
K
R
E
L
G
E
G
A
F
G
K
V
F
L
A
E
-
C
Y
N
L
C
-------
K
I
-
L
---
V
A
V
K
T
L
-----
A
S
D
N
A
R
K
D
F
H
R
E
A
E
L
L
T
N
L
-
Q
H
E
H
I
V
K
F
Y
G
V
C
V
E
G
D
P
L
I
M
V
F
E
Y
M
K
H
G
D
L
N
K
F
L
R
A
H
G
P
-------
D
----
A
V
L
M
A--
N
--------
P
--
P
T
-
E
----
L
T
---
Q
S
Q
M
L
H
I
A
Q
Q
I
A
A
G
M
V
Y
L
A
S
Q
H
F
V
H
R
D
L
A
T
R
N
C
L
V
---
G
E
N
--
L
L
V
K
I
G
D
F
G
M
S
R
--
Y
S
T
D
Y
Y
R
V
G
G
H
T
M
L
P
I
R
W
M
P
P
E
S
I
M
Y
R
K
F
T
T
E
S
D
V
W
S
L
G
V
V
L
W
E
I
F
T
Y
G
K
Q
P
W
Y
Q
L
S
N
N
E
V
I
E
C
I
T
Q
G
R
V
L
Q
R
P
R
T
C
P
Q
E
V
Y
E
L
M
L
G
C
W
Q
R
E
P
H
M
R
K
N
I
K
G
I
H
T
---
L
L
Q
N
L
A
K
A
S
P
V
Y
L
D
I
L
G
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
60
PsiBlast_CBE
57.42
45%
-81
- C1 -
3EKN
1
A:
[9-284]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
P
D
E
W
-------
E
V
S
R
E
K
I
T
L
L
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
N
-
A
R
D
I
I
K
G
--
E
A
-
E
T
-
R
---
V
A
V
K
T
V
--
N
E
S
A
S
L
R
E
R
I
E
F
L
N
E
A
S
V
M
K
G
F
-
T
C
H
H
V
V
R
L
L
G
V
V
S
K
G
Q
P
T
L
V
V
M
E
L
M
A
H
G
D
L
K
S
Y
L
R
S
L
R
P
-------
E
AENN
P
------
G
--------
R
--
P
P
-
P
-----
T
---
L
Q
E
M
I
Q
M
A
A
E
I
A
D
G
M
A
Y
L
N
A
K
K
F
V
H
R
N
L
A
A
R
N
C
M
V
---
A
H
D
--
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
T
D
Y
Y
R
K
G
---
L
L
P
V
R
W
M
A
P
E
S
L
K
D
G
V
F
T
T
S
S
D
M
W
S
F
G
V
V
L
W
E
I
T
S
L
A
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
K
F
V
M
D
G
G
Y
L
D
Q
P
D
N
C
P
E
R
V
T
D
L
M
R
M
C
W
Q
F
N
P
N
M
R
P
T
F
L
E
I
V
N
---
L
L
K
D
D
L
H
P
S
F
P
E
V
S
F
F
H
S
E
E
N
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
58
PsiBlast_CBE
57.35
45%
-75
- C1 -
4IBM
1
?
B:
[10-283]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
E
W
-------
E
V
S
R
E
K
I
T
L
L
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
N
-
A
R
D
I
I
K
G
--
E
A
-
E
T
-
R
---
V
A
V
K
T
V
--
N
E
S
A
S
L
R
E
R
I
E
F
L
N
E
A
S
V
M
K
G
F
-
T
C
H
H
V
V
R
L
L
G
V
V
S
---
P
T
L
V
V
M
E
L
M
A
H
G
D
L
K
S
Y
L
R
S
L
R
P
-------
E
AENN
P
------
G
--------
R
--
P
P
-
P
-----
T
---
L
Q
E
M
I
Q
M
A
A
E
I
A
D
G
M
A
Y
L
N
A
K
K
F
V
H
R
D
L
A
A
R
N
C
M
V
---
A
H
D
--
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
T
D
Y
Y
R
K
G
G
K
G
L
L
P
V
R
W
M
A
P
E
S
L
K
D
G
V
F
T
T
S
S
D
M
W
S
F
G
V
V
L
W
E
I
T
S
L
A
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
K
F
V
M
D
G
G
Y
L
D
Q
P
D
N
C
P
E
R
V
T
D
L
M
R
M
C
W
Q
F
N
P
N
M
R
P
T
F
L
E
I
V
N
---
L
L
K
D
D
L
H
P
S
F
P
E
V
S
F
F
H
S
E
E
N
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
87
PsiBlast_CBE
57.28
37%
-85
- C1 -
3TT0
4
B:
[52-348]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
V
S
E
Y
E
LPEDPRW
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
-
A
I
G
L
D
K
D
K-
P
N
-
R
V
T
K
---
V
A
V
K
M
L
--
K
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
-----------------------------------
Q
----
L
S
---
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
--
N
V
M
K
I
A
D
F
G
L
A
-----------------
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
V
P
V
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
---
D
L
D
R
I
V
A
L
T
S
N
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
61
PsiBlast_CBE
56.78
45%
-83
- C1 -
3EKK
1
A:
[9-284]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
P
D
E
W
-------
E
V
S
R
E
K
I
T
L
L
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
N
-
A
R
D
I
I
K
G
--
E
A
-
E
T
-
R
---
V
A
V
K
T
V
--
N
E
S
A
S
L
R
E
R
I
E
F
L
N
E
A
S
V
M
K
G
F
-
T
C
H
H
V
V
R
L
L
G
V
V
S
K
G
Q
P
T
L
V
V
M
E
L
M
A
H
G
D
L
K
S
Y
L
R
S
L
R
P
-------
E
AENN
P
------
G
--------
R
--
P
P
-
P
-----
T
---
L
Q
E
M
I
Q
M
A
A
E
I
A
D
G
M
A
Y
L
N
A
K
K
F
V
H
R
N
L
A
A
R
N
C
M
V
---
A
H
D
--
F
T
V
K
I
G
D
F
------------------
L
L
P
V
R
W
M
A
P
E
S
L
K
D
G
V
F
T
T
S
S
D
M
W
S
F
G
V
V
L
W
E
I
T
S
L
A
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
K
F
V
M
D
G
G
Y
L
D
Q
P
D
N
C
P
E
R
V
T
D
L
M
R
M
C
W
Q
F
N
P
N
M
R
P
T
F
L
E
I
V
N
---
L
L
K
D
D
L
H
P
S
F
P
E
V
S
F
F
H
S
E
E
N
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
59
PsiBlast_CBE
56.61
45%
-76
- C1 -
4IBM
1
?
A:
[8-283]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
P
D
E
W
-------
E
V
S
R
E
K
I
T
L
L
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
N
-
A
R
D
I
I
K
G
--
E
A
-
E
T
-
R
---
V
A
V
K
T
V
--
N
E
S
A
S
L
R
E
R
I
E
F
L
N
E
A
S
V
M
K
G
F
-
T
C
H
H
V
V
R
L
L
G
V
V
S
K
G
Q
P
T
L
V
V
M
E
L
M
A
H
G
D
L
K
S
Y
L
R
S
L
R
P
-------
E
AENN
P
------
G
--------
R
--
P
P
-
P
-----
T
---
L
Q
E
M
I
Q
M
A
A
E
I
A
D
G
M
A
Y
L
N
A
K
K
F
V
H
R
D
L
A
A
R
N
C
M
V
---
A
H
D
--
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
T
D
Y
Y
R
K
G
G
K
G
L
L
P
V
R
W
M
A
P
E
S
L
K
D
G
V
F
T
T
S
S
D
M
W
S
F
G
V
V
L
W
E
I
T
S
L
A
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
K
F
V
M
D
G
G
Y
L
D
Q
P
D
N
C
P
E
R
V
T
D
L
M
R
M
C
W
Q
F
N
P
N
M
R
P
T
F
L
E
I
V
N
---
L
L
K
D
D
L
H
P
S
F
P
E
V
S
F
F
H
S
E
E
N
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
92
PsiBlast_CBE
56.39
40%
-83
- C1 -
4QRC
1
A:
[29-314]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
W
-------
E
F
P
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
R
A
E
-
A
F
G
M
--
D
--
P
A
R
P
D
-
Q
A
S
T
V
A
V
K
M
L
--
K
D
N
A
S
D
K
D
L
A
D
L
V
S
E
M
E
V
M
K
L
I
G
R
H
K
N
I
I
N
L
L
G
V
C
T
Q
E
G
P
L
Y
V
I
V
E
C
A
A
K
G
N
L
R
E
F
L
R
A
R
R
P
PGPDL--
S
----
P
------
D
--------
G
--
P
R
-
S
SEGP
L
S
---
F
P
V
L
V
S
C
A
Y
Q
V
A
R
G
M
Q
Y
L
E
S
R
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
--
N
V
M
K
I
A
D
F
G
L
A
R
G
V
H
H
I
D
Y
Y
K
K
T
S
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
E
V
Y
T
H
Q
S
D
V
W
S
F
G
I
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
I
P
V
E
E
L
F
S
L
L
R
E
G
H
R
M
D
R
P
P
H
C
P
P
E
L
Y
G
L
M
R
E
C
W
H
A
A
P
S
Q
R
P
T
F
K
Q
L
V
E
---
A
L
D
K
V
L
L
A
V
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
96
PsiBlast_CBE
56.08
39%
-84
- C1 -
5AM7
1
B:
[17-300]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
---
G
Q
V
V
L
A
E
-
A
I
G
L
D
K
D
K-
P
N
-
R
V
T
K
---
V
A
V
K
M
L
--
K
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
M
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
P
PG---------------------------P-
E
E
-
Q
----
L
S
---
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
--
N
V
M
K
I
A
D
F
G
L
A
R
-----
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
V
P
V
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
---
D
L
D
R
I
V
A
L
T
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
78
PsiBlast_CBE
55.72
42%
-87
- C1 -
3BKB
7
A:
[114-370]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
L
V
L
G
E
Q
I
G
R
G
N
F
G
E
V
F
S
G
R
-
L
R
A
-------
D
-
N
T
-
L
---
V
A
V
K
S
C
--
R
E
T
L
P
P
D
L
K
A
K
F
L
Q
E
A
R
I
L
K
Q
Y
-
S
H
P
N
I
V
R
L
I
G
V
C
T
Q
K
Q
P
I
Y
I
V
M
E
L
V
Q
G
G
D
F
L
T
F
L
R
-----------------------
T
--------
E
--
G
A
-
R
----
L
R
---
V
K
T
L
L
Q
M
V
G
D
A
A
A
G
M
E
Y
L
E
S
K
C
C
I
H
R
D
L
A
A
R
N
C
L
V
T
---
E
K
--
N
V
L
K
I
S
D
F
G
M
S
R
E
E
A
D
G
V
Y
A
A
S
G
G
L
R
Q
V
P
V
K
W
T
A
P
E
A
L
N
Y
G
R
Y
S
S
E
S
D
V
W
S
F
G
I
L
L
W
E
T
F
S
L
G
A
S
P
Y
P
N
L
S
N
Q
Q
T
R
E
F
V
E
K
G
G
R
L
P
C
P
E
L
C
P
D
A
V
F
R
L
M
E
Q
C
W
A
Y
E
P
G
Q
R
P
S
F
S
T
I
Y
Q
---
E
L
Q
S
I
R
K
R
H
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
102
PsiBlast_CBE
55.61
39%
-84
- C1 -
4RWJ
1
FGFR1_HUMAN
A:
[24-307]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
-
A
I
G
L
D
K
D
K-
P
N
-
R
V
T
K
---
V
A
V
K
M
L
--
K
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
P
PGLEYSY
N
----
P
------
S
--------
H
NP
E
E
-
Q
----
L
S
---
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
--
N
V
M
K
I
A
D
F
G
L
A
R
D
I
H
H
I
D
Y
Y
K
K
T
-
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
V
P
V
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
---
D
L
D
R
I
V
A
L
T
S
N
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
91
PsiBlast_CBE
55.35
39%
-79
* C1 *
4RWK
1
FGFR1_HUMAN
A:
[24-307]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
-
A
I
G
L
D
K
D
K-
P
N
-
R
V
T
K
---
V
A
V
K
M
L
--
K
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
M
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
P
PGLEYSY
N
----
P
------
S
--------
H
NP
E
E
-
Q
----
L
S
---
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
--
N
V
M
K
I
A
D
F
G
L
A
R
D
I
H
H
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
V
P
V
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
---
D
L
D
R
I
V
A
L
T
S
N
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
97
PsiBlast_CBE
55.34
39%
-87
- C1 -
5AM7
1
FGFR1_HUMAN
A:
[17-300]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
---
G
Q
V
V
L
A
E
-
A
I
G
L
D
K
D
K-
P
N
-
R
V
T
K
---
V
A
V
K
M
L
--
K
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
M
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
P
PG---------------------------P-
E
E
-
Q
----
L
S
---
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
--
N
V
M
K
I
A
D
F
G
L
A
R
D
I
H
H
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
V
P
V
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
---
D
L
D
R
I
V
A
L
T
S
N
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
88
PsiBlast_CBE
54.77
37%
-80
- C1 -
3TT0
1
FGFR1_HUMAN
A:
[54-348]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
E
Y
E
LPEDPRW
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
-
A
I
G
L
D
K
D
K-
P
N
-
R
V
T
K
---
V
A
V
K
M
L
--
K
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
P
PGLEYSY
N
----
P
------
S
--------
H
NP
E
E
-
Q
----
L
S
---
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
--
N
V
M
K
I
A
D
F
G
L
A
R
D
I
H
H
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
V
P
V
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
---
D
L
D
R
I
V
A
L
T
S
N
Q
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
72
PsiBlast_CBE
54.60
40%
-83
- C1 -
3V5Q
1
NTRK3_HUMAN
A:
[6-287]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
I
H
V
Q
-------
H
I
K
R
R
D
I
V
L
K
R
E
L
------
K
V
F
L
A
E
-
C
Y
N
L
S
P
T
--
K
D
-
K
M
-
L
---
V
A
V
K
A
L
--
P
T
L
A
A
R
K
D
---
F
Q
R
E
A
E
L
L
T
N
L
-
Q
H
E
H
I
V
K
F
Y
G
V
C
G
D
G
D
P
L
I
M
V
F
E
Y
M
K
H
G
D
L
N
K
F
L
R
A
H
G
P
----------------------------------
E
----
L
G
---
L
S
Q
M
L
H
I
A
S
Q
I
A
S
G
M
V
Y
L
A
S
Q
H
F
V
H
R
D
L
A
T
R
N
C
L
V
---
G
A
N
--
L
L
V
K
I
G
D
F
G
M
--
D
V
Y
S
T
D
Y
Y
R
----
T
M
L
P
I
R
W
M
P
P
E
S
I
M
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
I
L
W
E
I
F
T
Y
G
K
Q
P
W
F
Q
L
S
N
T
E
V
I
E
C
I
T
Q
G
R
V
L
E
R
P
R
V
C
P
K
E
V
Y
D
V
M
L
G
C
W
Q
R
E
P
Q
Q
R
L
N
I
K
E
I
Y
K
---
I
L
H
A
L
G
K
A
T
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
76
PsiBlast_CBE
54.55
43%
-77
- C1 -
4CSV
1
?
A:
[5-265]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
-------
E
I
P
R
S
E
I
T
L
E
R
K
L
G
S
G
Q
F
G
E
V
Y
E
G
K
-
W
R
N
Y
N
--------
I
-
E
---
V
A
V
K
T
L
--
K
E
G
T
M
S
V
E
E
--
F
L
Q
E
A
Q
I
M
K
K
L
-
K
H
P
N
L
V
Q
L
Y
G
V
C
T
K
E
P
P
I
Y
I
I
T
E
Y
M
S
H
G
S
L
L
D
Y
L
R
D
C
---------------------
V
--------
N
--
A
Q
-
A
----
L
--------
L
D
M
A
A
Q
V
A
S
G
M
A
Y
L
E
S
Q
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
--
N
V
V
K
V
A
D
F
G
------------------
F
P
I
K
W
T
A
P
E
A
I
S
Y
N
R
F
S
I
K
S
D
V
W
A
F
G
I
L
L
W
E
I
F
T
Y
G
Q
V
P
Y
P
G
M
S
G
S
E
V
I
E
Q
V
E
R
G
Y
R
M
P
R
P
Q
G
C
P
E
E
I
Y
E
L
M
L
Q
C
W
N
K
S
P
E
E
R
P
T
F
A
E
T
L
H
---
A
L
E
T
M
F
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
83
PsiBlast_CBE
53.32
41%
-80
- C1 -
4XCU
1
A:
[11-287]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
W
-------
E
F
P
R
D
R
L
V
L
G
K
P
L
G
E
---
G
Q
V
V
R
A
E
-
A
F
G
M
--
D
--
P
A
R
P
D
-
Q
A
S
T
V
A
V
K
M
L
--
K
D
N
A
S
D
K
D
L
A
D
L
V
S
E
M
E
V
M
K
L
I
G
R
H
K
N
I
I
N
L
L
G
V
C
T
Q
E
G
P
L
Y
V
I
V
E
C
A
A
K
G
N
L
R
E
F
L
R
A
R
R
P
-------
P
----
G
------
S
--------
S
--
E
G
-
P
----
L
S
---
F
P
V
L
V
S
C
A
Y
Q
V
A
R
G
M
Q
Y
L
E
S
R
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
--
N
V
M
K
I
A
D
F
G
L
A
R
G
V
H
H
I
D
Y
Y
K
K
T
S
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
I
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
I
P
V
E
E
L
F
S
L
L
R
E
G
H
R
M
D
R
P
P
H
C
P
P
E
L
Y
G
L
M
R
E
C
W
H
A
A
P
S
Q
R
P
T
F
K
Q
L
V
E
---
A
L
D
K
V
L
L
A
V
S
H
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
75
PsiBlast_CBE
50.18
43%
-78
- C1 -
4UEU
1
?
A:
[4-265]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
-------
E
I
P
R
S
E
I
T
L
E
R
K
L
G
S
G
Q
F
G
E
V
Y
E
G
K
-
W
R
N
Y
N
--------
I
-
E
---
V
A
V
K
T
L
--
K
E
G
T
M
S
V
E
E
--
F
L
Q
E
A
Q
I
M
K
K
L
-
K
H
P
N
L
V
Q
L
Y
G
V
C
T
K
E
P
P
I
Y
I
I
T
E
Y
M
S
H
G
S
L
L
D
Y
L
R
D
C
E
G
-------
H
----
T
------
V
--------
N
--
A
Q
-
A
----
L
--------
L
D
M
A
A
Q
V
A
S
G
M
A
Y
L
E
S
Q
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
--
N
V
V
K
V
A
D
F
G
L
A
R
L
I
-----------
A
K
F
P
I
K
W
T
A
P
E
A
I
S
Y
N
R
F
S
I
K
S
D
V
W
A
F
G
I
L
L
W
E
I
F
T
Y
G
Q
V
P
Y
P
G
M
S
G
S
E
V
I
E
Q
V
E
R
G
Y
R
M
P
R
P
Q
G
C
P
E
E
I
Y
E
L
M
L
Q
C
W
N
K
S
P
E
E
R
P
T
F
A
E
T
L
H
---
A
L
E
T
M
F
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
73
PsiBlast_CBE
44.14
40%
-52
- C1 -
4YMJ
4
B:
[6-287]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
I
H
V
Q
-------
H
I
K
R
R
D
I
V
L
K
R
E
L
G
E
G
A
F
G
K
V
F
L
A
E
-
C
Y
N
L
S
P
T
--
K
D
-
K
M
-
L
---
V
A
V
K
A
L
K
D
P
T
L
A
A
R
K
D
---
F
Q
R
E
A
E
L
L
T
N
L
-
Q
H
E
H
I
V
K
F
Y
G
V
C
G
D
G
-
P
L
I
M
V
F
E
Y
M
K
H
G
D
L
N
K
F
L
R
A
H
G
P
---------------------------------G
E
----
L
G
---
L
S
Q
M
L
H
I
A
S
Q
I
A
S
G
M
V
Y
L
A
S
Q
H
F
V
H
R
D
L
A
T
R
N
C
L
V
---
G
A
N
--
L
L
V
K
I
G
D
F
G
M
S
R
D
V
Y
S
T
D
Y
Y
R
---
H
T
M
L
P
I
R
W
M
P
P
E
S
I
M
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
I
L
W
E
I
F
T
Y
G
K
Q
P
W
F
Q
L
S
N
T
E
V
I
E
C
I
T
Q
G
R
V
L
E
R
P
R
V
C
P
K
E
V
Y
D
V
M
L
G
C
W
Q
R
E
P
Q
Q
R
L
N
I
K
E
I
Y
K
---
I
L
H
A
L
G
K
A
T
P
I
Y
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
74
PsiBlast_CBE
42.18
40%
-48
- C1 -
4YMJ
4
NTRK3_HUMAN
A:
[6-287]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
I
H
V
Q
-------
H
I
K
R
R
D
I
V
L
K
R
E
L
G
E
G
A
F
G
K
V
F
L
A
E
-
C
Y
N
L
S
P
T
--
K
D
-
K
M
-
L
---
V
A
V
K
A
L
K
D
P
T
L
A
A
R
K
D
---
F
Q
R
E
A
E
L
L
T
N
L
-
Q
H
E
H
I
V
K
F
Y
G
V
C
G
D
G
D
P
L
I
M
V
F
E
Y
M
K
H
G
D
L
N
K
F
L
R
A
H
G
P
---------------------------------G
E
----
L
G
---
L
S
Q
M
L
H
I
A
S
Q
I
A
S
G
M
V
Y
L
A
S
Q
H
F
V
H
R
D
L
A
T
R
N
C
L
V
---
G
A
N
--
L
L
V
K
I
G
D
F
G
---
D
V
Y
S
T
D
Y
Y
R
---
H
T
M
L
P
I
R
W
M
P
P
E
S
I
M
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
I
L
W
E
I
F
T
Y
G
K
Q
P
W
F
Q
L
S
N
T
E
V
I
E
C
I
T
Q
G
R
V
L
E
R
P
R
V
C
P
K
E
V
Y
D
V
M
L
G
C
W
Q
R
E
P
Q
Q
R
L
N
I
K
E
I
Y
K
---
I
L
H
A
L
G
K
A
T
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------