@TOME V2.3
(Nov 2016)

Ref. - - Doc.
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Alignment:

3D Common Core:

Structural Clustering:

Modeller Result :

Complexes Modeling
Templates Information:
Sequence & Result Tab:

Values color: [ Good | Correct | Middling | Bad ]Sequence color : MutatedHelixStrandConserved

Query sequence : ALK_HUMAN: (2015-10-03 )
MGAIGLLWLLPLLLSTAAVGSGMGTGQRAGSPAAGPPLQPREPLSYSRLQRKSLAVDFVVPSLFRVYARDLLLPPSSSELKAGRPEARGSLALDCAPLLRLLGPAPGVSWTAGSPAPAEARTLSRVLKGGSVRKLRRAKQLVLELGEEAILEGCVGPPGEAAVGLLQFNLSELFSWWIRQGEGRLRIRLMPEKKASEVGREGRLSAAIRASQPRLLFQIFGTGHSSLESPTNMPSPSPDYFTWNLTWIMKDSFPFLSHRSRYGLECSFDFPCELEYSPPLHDLRNQSWSWRRIPSEEASQMDLLDGPGAERSKEMPRGSFLLLNTSADSKHTILSPWMRSSSEHCTLAVSVHRHLQPSGRYIAQLLPHNEAAREILLMPTPGKHGWTVLQGRIGRPDNPFRVALEYISSGNRSLSAVDFFALKNCSEGTSPGSKMALQSSFTCWNGTVLQLGQACDFHQDCAQGEDESQMCRKLPVGFYCNFEDGFCGWTQGTLSPHTPQWQVRTLKDARFQDHQDHALLLSTTDVPASESATVTSATFPAPIKSSPCELRMSWLIRGVLRGNVSLVLVENKTGKEQGRMVWHVAAYEGLSLWQWMVLPLLDVSDRFWLQMVAWWGQGSRAIVAFDNISISLDCYLTISGEDKILQNTAPKSRNLFERNPNKELKPGENSPRQTPIFDPTVHWLFTTCGASGPHGPTQAQCNNAYQNSNLSVEVGSEGPLKGIQIWKVPATDTYSISGYGAAGGKGGKNTMMRSHGVSVLGIFNLEKDDMLYILVGQQGEDACPSTNQLIQKVCIGENNVIEEEIRVNRSVHEWAGGGGGGGGATYVFKMKDGVPVPLIIAAGGGGRAYGAKTDTFHPERLENNSSVLGLNGNSGAAGGGGGWNDNTSLLWAGKSLQEGATGGHSCPQAMKKWGWETRGGFGGGGGGCSSGGGGGGYIGGNAASNNDPEMDGEDGVSFISPLGILYTPALKVMEGHGEVNIKHYLNCSHCEVDECHMDPESHKVICFCDHGTVLAEDGVSCIVSPTPEPHLPLSLILSVVTSALVAALVLAFSGIMIVYRRKHQELQAMQMELQSPEYKLSKLRTSTIMTDYNPNYCFAGKTSSISDLKEVPRKNITLIRGLGHGAFGEVYEGQVSGMPNDPSPLQVAVKTLPEVCSEQDELDFLMEALIISKFNHQNIVRCIGVSLQSLPRFILLELMAGGDLKSFLRETRPRPSQPSSLAMLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGPGRVAKIGDFGMARDIYRASYYRKGGCAMLPVKWMPPEAFMEGIFTSKTDTWSFGVLLWEIFSLGYMPYPSKSNQEVLEFVTSGGRMDPPKNCPGPVYRIMTQCWQHQPEDRPNFAIILERIEYCTQDPDVINTALPIEYGPLVEEEEKVPVRPKDPEGVPPLLVSQQAKREEERSPAAPPPLPTTSSGKAAKKPTAAEISVRVPRGPAVEGGHVNMAFSQSNPPSELHKVHGSRNKPTSLWNPTYGSWFTEKPTKKNNPIAKKEPHDRGNLGLEGSCTVPPNVATGRLPGASLLLEPSSLTANMKEVPLFRLRHFPCGNVNYGYQQQGLPLEAATAPGAGHYEDTILKSKNSMNQPGP

Atome Classification :

(77 SA) .........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770.......780.......790.......800.......810.......820.......830.......840.......850.......860.......870.......880.......890.......900.......910.......920.......930.......940.......950.......960.......970.......980.......990.......1000......1010......1020......1030......1040......1050......1060......1070......1080......1090......1100......-------1110......1120......1130.-.....1140..-..-.---...1150-.......1160......1170.-.....1180......1190......1200......1210-------.----.------.--------.--..-1220-..---.......1230......1240......1250......1260--......1270......1280......1290......1300......1310......1320......1330......1340......1350......1360......1370......1380-........1390......1400......1410......1420......1430......1440......1450......1460......1470......1480......1490......1500......1510......1520......1530......1540......1550......1560......1570......1580......1590......1600......1610......1620
(Atome) (Ident) (Tito) (Num) (Ligand) (Uniprot) MGAIGLLWLLPLLLSTAAVGSGMGTGQRAGSPAAGPPLQPREPLSYSRLQRKSLAVDFVVPSLFRVYARDLLLPPSSSELKAGRPEARGSLALDCAPLLRLLGPAPGVSWTAGSPAPAEARTLSRVLKGGSVRKLRRAKQLVLELGEEAILEGCVGPPGEAAVGLLQFNLSELFSWWIRQGEGRLRIRLMPEKKASEVGREGRLSAAIRASQPRLLFQIFGTGHSSLESPTNMPSPSPDYFTWNLTWIMKDSFPFLSHRSRYGLECSFDFPCELEYSPPLHDLRNQSWSWRRIPSEEASQMDLLDGPGAERSKEMPRGSFLLLNTSADSKHTILSPWMRSSSEHCTLAVSVHRHLQPSGRYIAQLLPHNEAAREILLMPTPGKHGWTVLQGRIGRPDNPFRVALEYISSGNRSLSAVDFFALKNCSEGTSPGSKMALQSSFTCWNGTVLQLGQACDFHQDCAQGEDESQMCRKLPVGFYCNFEDGFCGWTQGTLSPHTPQWQVRTLKDARFQDHQDHALLLSTTDVPASESATVTSATFPAPIKSSPCELRMSWLIRGVLRGNVSLVLVENKTGKEQGRMVWHVAAYEGLSLWQWMVLPLLDVSDRFWLQMVAWWGQGSRAIVAFDNISISLDCYLTISGEDKILQNTAPKSRNLFERNPNKELKPGENSPRQTPIFDPTVHWLFTTCGASGPHGPTQAQCNNAYQNSNLSVEVGSEGPLKGIQIWKVPATDTYSISGYGAAGGKGGKNTMMRSHGVSVLGIFNLEKDDMLYILVGQQGEDACPSTNQLIQKVCIGENNVIEEEIRVNRSVHEWAGGGGGGGGATYVFKMKDGVPVPLIIAAGGGGRAYGAKTDTFHPERLENNSSVLGLNGNSGAAGGGGGWNDNTSLLWAGKSLQEGATGGHSCPQAMKKWGWETRGGFGGGGGGCSSGGGGGGYIGGNAASNNDPEMDGEDGVSFISPLGILYTPALKVMEGHGEVNIKHYLNCSHCEVDECHMDPESHKVICFCDHGTVLAEDGVSCIVSPTPEPHLPLSLILSVVTSALVAALVLAFSGIMIVYRRKHQELQAMQMELQSPEYKLSKLRTSTIMTDYNPNYCFAGKTSSISDLK-------EVPRKNITLIRGLGHGAFGEVYEGQ-VSGMPND--PS-PL-Q---VAVKTL--PEVCSEQDELDFLMEALIISKF-NHQNIVRCIGVSLQSLPRFILLELMAGGDLKSFLRETRP-------R----P------S--------Q--PS-S----LA---MLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGPG--RVAKIGDFGMARDIYRASYYRKGGCAMLPVKWMPPEAFMEGIFTSKTDTWSFGVLLWEIFSLGYMPYPSKSNQEVLEFVTSGGRMDPPKNCPGPVYRIMTQCWQHQPEDRPNFAIILE---RIEYCTQDPDVINTALPIEYGPLVEEEEKVPVRPKDPEGVPPLLVSQQAKREEERSPAAPPPLPTTSSGKAAKKPTAAEISVRVPRGPAVEGGHVNMAFSQSNPPSELHKVHGSRNKPTSLWNPTYGSWFTEKPTKKNNPIAKKEPHDRGNLGLEGSCTVPPNVATGRLPGASLLLEPSSLTANMKEVPLFRLRHFPCGNVNYGYQQQGLPLEAATAPGAGHYEDTILKSKNSMNQPGP
3 PsiBlast_PDB 90.86100%-105 - C1 -3AOX A:[19-334] -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------STIMTDYNPNYCFAGKTSSISDLK-------EVPRKNITLIRGLG----GEVYEGQ-VS----------PL-Q---VAVKTL--PEVCSEQDELDFLMEALIISKF-NHQNIVRCIGVSLQSLPRFILLELMAGGDLKSFLRETRP-------R----P------S--------Q--PS-S----LA---MLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGPG--RVAKIGDFGMARDIYRA-------CAMLPVKWMPPEAFMEGIFTSKTDTWSFGVLLWEIFSLGYMPYPSKSNQEVLEFVTSGGRMDPPKNCPGPVYRIMTQCWQHQPEDRPNFAIILE---RIEYCTQDPDVINTALPIEY---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10 PsiBlast_PDB 90.4599%-101 - C1 -4FOD A:[8-328] ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TSTIMTDYNPNYSFAGKTSSISDLK-------EVPRKNITLIRGLGHGAFGEVYEGQ-VS--------S-PL-Q---VAVKTL--PEVCSEQDELDFLMEALIISKF-NHQNIVRCIGVSLQSLPRFILLELMAGGDLKSFLRETRP-------R----P------S--------Q--PS-S----LA---MLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGPG--RVAKIGDFGMARDIYRA-------CAMLPVKWMPPEAFMEGIFTSKTDTWSFGVLLWEIFSLGYMPYPSKSNQEVLEFVTSGGRMDPPKNCPGPVYRIMTQCWQHQPEDRPNFAIILE---RIEYCTQDPDVINTALPIEYGPLV-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7 PsiBlast_PDB 90.1499%-103 - C1 -3LCS A:[30-333] ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YCFAGKTSSISDLK-------EVPRKNITLIRGLGHGAFGEVYEGQ-VSGMPND--PS-PL-Q---VAVKTL--PEVCSEQDELDFLMEALIISKF-NHQNIVRCIGVSLQSLPRFILLELMAGGDLKSFLRETRP-------R----P------S--------Q--PS-S----LA---MLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGPG--RVAKIGDFGMARDIYRAGYYRKGGCAMLPVKWMPPEAFMEGIFTSKTDTWSFGVLLWEIFSLGYMPYPSKSNQEVLEFVTSGGRMDPPKNCPGPVYRIMTQCWQHQPEDRPNFAIILE---RIEYCTQDPDVINTALPI-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9 PsiBlast_PDB 90.0499%-101 - C1 -4DCE ALK_HUMAN A:[16-325] ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NPNYSFAGKTSSISDLK-------EVPRKNITLIRGLGH---GEVYEGQ-VS-------PS-PL-Q---VAVKTL--PEVCSEQDELDFLMEALIISKF-NHQNIVRCIGVSLQSLPRFILLELMAGGDLKSFLRETRP-------R----P------S--------Q--PS-S----LA---MLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGPG--RVAKIGDF--------------GGCAMLPVKWMPPEAFMEGIFTSKTDTWSFGVLLWEIFSLGYMPYPSKSNQEVLEFVTSGGRMDPPKNCPGPVYRIMTQCWQHQPEDRPNFAIILE---RIEYCTQDPDVINTALPIEYG--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
34 PsiBlast_CBE 89.93100%-102 - C1 -2XB7 A:[3-309] --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NYCFAGKTSSISDLK-------EVPRKNITLIRGLGHGAFGEVYEGQ-VS----------PL-Q---VAVKTL--PEVCSEQDELDFLMEALIISKF-NHQNIVRCIGVSLQSLPRFILLELMAGGDLKSFLRETRP-------R----P------S--------Q--PS-S----LA---MLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGPG--RVAKIGDFGMA--------------AMLPVKWMPPEAFMEGIFTSKTDTWSFGVLLWEIFSLGYMPYPSKSNQEVLEFVTSGGRMDPPKNCPGPVYRIMTQCWQHQPEDRPNFAIILE---RIEYCTQDPDVINTALPIEY---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5 PsiBlast_PDB 89.6899%-101 - C1 -4MKC A:[50-358] ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NPNYCFAGKTSSISDLK-------EVPRKNITLIRGLGHGAFGEVYEGQ-VS--------S-PL-Q---VAVKTL--PEVCSEQDELDFLMEALIISKF-NHQNIVRCIGVSLQSLPRFILLELMAGGDLKSFLRETRP-------R----P------S--------Q--PS-S----LA---MLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGPG--RVAKIGDFGMARDIYRAGYYRKGGCAMLPVKWMPPEAFMEGIFTSKTDTWSFGVLLWEIFSLGYMPYPSKSNQEVLEFVTSGGRMDPPKNCPGPVYRIMTQCWQHQPEDRPNFAIILE---RIEYCTQDPDVINTALPIEY---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2 PsiBlast_PDB 89.6299%-102 - C1 -4FOC A:[36-345] ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NPNYSFAGKTSSISDLK-------EVPRKNITLIRGLGHGAFGEVYEGQ-VS--------S-PL-Q---VAVKTL--PEVCSEQDELDFLMEALIISKF-NHQNIVRCIGVSLQSLPRFILLELMAGGDLKSFLRETRP-------R----P------S--------Q--PS-S----LA---MLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGPG--RVAKIGDFGMARDIYR--------CAMLPVKWMPPEAFMEGIFTSKTDTWSFGVLLWEIFSLGYMPYPSKSNQEVLEFVTSGGRMDPPKNCPGPVYRIMTQCWQHQPEDRPNFAIILE---RIEYCTQDPDVINTALPIEYG--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4 PsiBlast_PDB 88.8499% -99 - C1 -3L9P A:[50-357] ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NPNYCFAGKTSSISDLK-------EVPRKNITLIRGLGHGAFGEVYEGQ-VSG-------S-PL-Q---VAVKTL--PEVCSEQDELDFLMEALIISKF-NHQNIVRCIGVSLQSLPRFILLELMAGGDLKSFLRETRP-------R----P------S--------Q--PS-S----LA---MLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGPG--RVAKIGDFGMARDIYRAGYYRKGGCAMLPVKWMPPEAFMEGIFTSKTDTWSFGVLLWEIFSLGYMPYPSKSNQEVLEFVTSGGRMDPPKNCPGPVYRIMTQCWQHQPEDRPNFAIILE---RIEYCTQDPDVINTALPIE----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21 PsiBlast_CBE 88.6999%-104 - C1 -4DCE B:[17-325] -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PNYSFAGKTSSISDLK-------EVPRKNITLIRGLGH----EVYEGQ-VS--------S-PL-Q---VAVKTL--PEVCSEQDELDFLMEALIISKF-NHQNIVRCIGVSLQSLPRFILLELMAGGDLKSFLRETRP-------R----P------S--------Q--PS-S----LA---MLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGPG--RVAKIGDF---------------GCAMLPVKWMPPEAFMEGIFTSKTDTWSFGVLLWEIFSLGYMPYPSKSNQEVLEFVTSGGRMDPPKNCPGPVYRIMTQCWQHQPEDRPNFAIILE---RIEYCTQDPDVINTALPIEYG--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6 PsiBlast_PDB 88.2499% -99 - C1 -3LCT A:[27-334] ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NPNYCFAGKTSSISDLK-------EVPRKNITLIRGLGHGAFGEVYEGQ-VSGMPND--PS-PL-Q---VAVKTL--PEVCSEQDELDFLMEALIISKF-NHQNIVRCIGVSLQSLPRFILLELMAGGDLKSFLRETRP-------R----P------S--------Q--PS-S----LA---MLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGPG--RVAKIGDFGMARDIYRAGYYRKGGCAMLPVKWMPPEAFMEGIFTSKTDTWSFGVLLWEIFSLGYMPYPSKSNQEVLEFVTSGGRMDPPKNCPGPVYRIMTQCWQHQPEDRPNFAIILE---RIEYCTQDPDVINTALPIE----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11 PsiBlast_PDB 87.7999% -99 - C1 -4FNZ A:[10-319] ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NPNYSFAGKTSSISDLK-------EVPRKNITLIRGLGH---GEVYEGQ-VSG-------S-PL-Q---VAVKTL--PEVCSEQDELDFLMEALIISKF-NHQNIVRCIGVSLQSLPRFILLELMAGGDLKSFLRETRP-------R----P------S--------Q--PS-S----LA---MLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGPG--RVAKIGDF---------------GCAMLPVKWMPPEAFMEGIFTSKTDTWSFGVLLWEIFSLGYMPYPSKSNQEVLEFVTSGGRMDPPKNCPGPVYRIMTQCWQHQPEDRPNFAIILE---RIEYCTQDPDVINTALPIEYG--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1 PsiBlast_PDB 87.7299%-102 - C1 -4FOB A:[36-345] ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NPNYSFAGKTSSISDLK-------EVPRKNITLIRGLGHGAFGEVYEGQ-VS--------S-PL-Q---VAVKTL--PEVCSEQDELDFLMEALIISKF-NHQNIVRCIGVSLQSLPRFILLELMAGGDLKSFLRETRP-------R----P------S--------------S----LA---MLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGPG--RVAKIGDFGMARDIYRA------GCAMLPVKWMPPEAFMEGIFTSKTDTWSFGVLLWEIFSLGYMPYPSKSNQEVLEFVTSGGRMDPPKNCPGPVYRIMTQCWQHQPEDRPNFAIILE---RIEYCTQDPDVINTALPIEYG--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13 PsiBlast_PDB 86.1699%-104 - C1 -4FNY A:[20-321] ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SSISDLK-------EVPRKNITLIRGLGH---GEVYEGQ-VSG---------PL-Q---VAVKTL--PEVCSEQDELDFLMEALIISKF-NHQNIVRCIGVSLQSLPRFILLELMAGGDLKSFLRETRP-------R----P------S-------------------LA---MLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGPG--RVAKIGDF----------------CAMLPVKWMPPEAFMEGIFTSKTDTWSFGVLLWEIFSLGYMPYPSKSNQEVLEFVTSGGRMDPPKNCPGPVYRIMTQCWQHQPEDRPNFAIILE---RIEYCTQDPDVINTALPIEYGPL------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
65 PsiBlast_CBE 65.2740% -85 - C1 -4AOJ C:[33-322] -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ACVH-------HIKRRDIVLKWELGEGAFGKVFLAE-CHNLLP---QD-KM-L---VAVKAL--KE-ASESARQDFQREAELLTML-QHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGP-------D------------------------G-P----LG---LGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLV---GQG--LVVKIGDFGM----------------MLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHA---RLQALAQAPP-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
67 PsiBlast_CBE 64.8340% -89 - C1 -4AOJ NTRK1_HUMAN A:[33-322] -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ACVH-------HIKRRDIVLKWELGEGAFGKVFLAE-CHNLLP------KM-L---VAVKAL--KE-ASESARQDFQREAELLTML-QHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGP-------D-----------------------PG-P----LG---LGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLV---GQG--LVVKIGDFG----------------TMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHA---RLQALAQAPP-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
55 PsiBlast_CBE 64.7843% -75 - C1 -3ETA INSR_HUMAN A:[12-305] ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EVSREKITLLRELGQGSFGMVYEGN-ARDIIKG--EA-ET-R---VAVKTV--NESASLRERIEFLNEASVMKGF-TCHHVVRLLGVVSKGQPTLVVMELMAHGDLKSYLRSLRP-------EAENNP------G--------R--PP-P-----T---LQEMIQMAAEIADGMAYLNAKKFVHRDLAARNCMV---AHD--FTVKIGDFGMTRDIYETDYYRKG-KGLLPVRWMAPESLKDGVFTTSSDMWSFGVVLWEITSLAEQPYQGLSNEQVLKFVMDGGYLDQPDNCPERVTDLMRMCWQFNPKMRPTFLEIVN---LLK------DDLHPSFP-EVSFFHSEENK------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
51 PsiBlast_CBE 64.3445% -83 - C1 -3LW0 IGF1R_HUMAN A:[6-285] ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VPDEW-------EVAREKITMSRELGQGSFGMVYEGV-AKGVVKD--EP-ET-R---VAIKTV--NEAASMRERIEFLNEASVMKEF-NCHHVVRLLGVVSQGQPTLVIMELMTRGDLKSYLRSLRP-----------------------------------------PPSLSKMIQMAGEIADGMAYLNANKFVHRDLAARNCMV---AED--FTVKIGDFGMTRDIYETDYYRKG---LLPVRWMSPESLKDGVFTTYSDVWSFGVVLWEIATLAEQPYQGLSNEQVLRFVMEGGLLDKPDNCPDMLFELMRMCWQYNPKMRPSFLEIIS---SIKEEMEPGFREVSFYYSEENK-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
66 PsiBlast_CBE 63.9540% -85 - C1 -4AOJ NTRK1_HUMAN B:[33-324] -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ACVH-------HIKRRDIVLKWELGEGAFGKVFLAE-CHNLLP------KM-L---VAVKAL--KE-ASESARQDFQREAELLTML-QHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGP-------D------------------------G-P----LG---LGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLV---GQG--LVVKIGDF-------------------LPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHA---RLQALAQAPPVY-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
69 PsiBlast_CBE 63.8540% -87 - C1 -4YNE A:[4-300] ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GSGIRVH-------HIKRRDIVLKWELGEGAFGKVFLAE-CHNLLP----D-KM-L---VAVKAL--KE------RQDFQREAELLTML-QHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGP-------D----A------KLLAGGEDVA--PG-P----LG---LGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLV---GQG--LVVKIGDFGMS-----TDYY----RTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHA---RLQALAQAPPVYLD---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
50 PsiBlast_CBE 63.7645% -83 - C1 -3LW0 IGF1R_HUMAN B:[6-285] ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VPDEW-------EVAREKITMSRELGQGSFGMVYEGV-AKGVVKD--EP-ET-R---VAIKTV--NEAASMRERIEFLNEASVMKEF-NCHHVVRLLGVVSQGQPTLVIMELMTRGDLKSYLRSLRP-----------------------------------------PPSLSKMIQMAGEIADGMAYLNANKFVHRDLAARNCMV---AED--FTVKIGDFGMTRDIYETDYYRKG---LLPVRWMSPESLKDGVFTTYSDVWSFGVVLWEIATLAEQPYQGLSNEQVLRFVMEGGLLDKPDNCPDMLFELMRMCWQYNPKMRPSFLEIIS---SIKEEMEPGFREVSFYYSEENK-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
38 PsiBlast_CBE 63.5044% -80 - C1 -1JQH IGF1R_HUMAN B:[6-289] --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ADVYVPDEW-------EVAREKITMSRELGQGSFGMVYEGV-AKGVVKD--EP-ET-R---VAIKTV--NEAASMRERIEFLNEASVMKEF-NCHHVVRLLGVVSQGQPTLVIMELMTRGDLKSYLRSLRP-----------------------------------------PPSLSKMIQMAGEIADGMAYLNANKFVHRDLAARNCMV---AED--FTVKIGDFGMT-------YYRKGGKGLLPVRWMSPESLKDGVFTTYSDVWSFGVVLWEIATLAEQPYQGLSNEQVLRFVMEGGLLDKPDNCPDMLFELMRMCWQYNPKMRPSFLEIIS---SIKEEMEPGFREVSFYYSEENK-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
48 PsiBlast_CBE 63.3845% -83 - C1 -3LW0 D:[6-285] ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VPDEW-------EVAREKITMSRELGQGSFGMVYEGV-AKGVVKD--EP-ET-R---VAIKTV--NEAASMRERIEFLNEASVMKEF-NCHHVVRLLGVVSQGQPTLVIMELMTRGDLKSYLRSLRP-----------------------------------------PPSLSKMIQMAGEIADGMAYLNANKFVHRDLAARNCMV---AED--FTVKIGDFGMTRDIYETDYYRKG---LLPVRWMSPESLKDGVFTTYSDVWSFGVVLWEIATLAEQPYQGLSNEQVLRFVMEGGLLDKPDNCPDMLFELMRMCWQYNPKMRPSFLEIIS---SIKEEMEPGFREVSFYYSEENK-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
54 PsiBlast_CBE 63.2043% -75 - C1 -3ETA B:[12-305] ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EVSREKITLLRELGQGSFGMVYEGN-ARDIIKG--EA-ET-R---VAVKTV--NESASLRERIEFLNEASVMKGF-TCHHVVRLLGVVSKGQPTLVVMELMAHGDLKSYLRSLRP-------EAENNP------G--------R--PP-P-----T---LQEMIQMAAEIADGMAYLNAKKFVHRDLAARNCMV---AHD--FTVKIGDFGMTRDIYETDYYRK--KGLLPVRWMAPESLKDGVFTTSSDMWSFGVVLWEITSLAEQPYQGLSNEQVLKFVMDGGYLDQPDNCPERVTDLMRMCWQFNPKMRPTFLEIVN---LLK------DDLHPSFP-EVSFFHSEENK------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
43 PsiBlast_CBE 63.2045% -81 - C1 -3NW7 A:[9-288] ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VPDEW-------EVAREKITMSRELGQGSFGMVYEGV-AKGVVKD--EP-ET-R---VAIKTV--NEAASMRERIEFLNEASVMKEF-NCHHVVRLLGVVSQGQPTLVIMELMTRGDLKSYLRSLRP-------E----M------E--------N--NP-V----LAPPSLSKMIQMAGEIADGMAYLNANKFVHRDLAARNCMV---AED--FTVKIGDFGMTRDIYETDYYRKG---LLPVRWMSPESLKDGVFTTYSDVWSFGVVLWEIATLAEQPYQGLSNEQVLRFVMEGGLLDKPDNCPDMLFELMRMCWQYNPKMRPSFLEIIS---SIKEEMEPGFREVSFYYSEENK-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
68 PsiBlast_CBE 62.8840% -80 - C1 -4YPS A:[4-297] ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GSGIRVH-------HIKRRDIVLKWELGE---GKVFLAE-CHNLL-----D-KM-L---VAVKAL------SESARQDFQREAELLTML-QHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGP-------D----A------KLLAGGEDVA--PG-P----LG---LGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLV---GQG--LVVKIGD--MSRDIYSTDYYRV---TMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHA---RLQALAQAPPV------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
44 PsiBlast_CBE 62.4945% -83 - C1 -3NW6 A:[9-288] ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VPDEW-------EVAREKITMSRELGQGSFGMVYEGV-AKGVVKD--EP-ET-R---VAIKTV--NEAASMRERIEFLNEASVMKEF-NCHHVVRLLGVVSQGQPTLVIMELMTRGDLKSYLRSLRP-------E----M------E--------N--NP-V----LAPPSLSKMIQMAGEIADGMAYLNANKFVHRDLAARNCMV---AED--FTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMSPESLKDGVFTTYSDVWSFGVVLWEIATLAEQPYQGLSNEQVLRFVMEGGLLDKPDNCPDMLFELMRMCWQYNPKMRPSFLEIIS---SIKEEMEPGFREVSFYYSEENK-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
49 PsiBlast_CBE 62.4145% -82 - C1 -3LW0 IGF1R_HUMAN C:[6-285] ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VPDEW-------EVAREKITMSRELGQGSFGMVYEGV-AKGVVKD--EP-ET-R---VAIKTV--NEAASMRERIEFLNEASVMKEF-NCHHVVRLLGVVSQGQPTLVIMELMTRGDLKSYLRSLRP-----------------------------------------PPSLSKMIQMAGEIADGMAYLNANKFVHRDLAARNCMV---AED--FTVKIGDFGMTRDIYETDYYRKG---LLPVRWMSPESLKDGVFTTYSDVWSFGVVLWEIATLAEQPYQGLSNEQVLRFVMEGGLLDKPDNCPDMLFELMRMCWQYNPKMRPSFLEIIS---SIKEEMEPGFREVSFYYSEENK-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
45 PsiBlast_CBE 62.2445% -85 - C1 -3NW5 A:[9-288] ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VPDEW-------EVAREKITMSRELGQGSFGMVYEGV-AKGVVKD--EP-ET-R---VAIKTV--NEAASMRERIEFLNEASVMKEF-NCHHVVRLLGVVSQGQPTLVIMELMTRGDLKSYLRSLRP-------E----M------E--------N--NP-V----LAPPSLSKMIQMAGEIADGMAYLNANKFVHRDLAARNCMV---AED--FTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMSPESLKDGVFTTYSDVWSFGVVLWEIATLAEQPYQGLSNEQVLRFVMEGGLLDKPDNCPDMLFELMRMCWQYNPKMRPSFLEIIS---SIKEEMEPGFREVSFYYSEENK-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
71 PsiBlast_CBE 61.8141% -86 - C1 -4PMP A:[2-286] ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VH-------HIKRRDIVLKWELGEGAFGKVFLAE-CHNLL-------KM-L---VAVKAL--K-----SARQDFQREAELLTML-QHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGP-------D----A------KLLAGGEDVA--PG-P----LG---LGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLV---GQG--LVVKIGDFGMSR-IYSTDYYRVG--TMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHA---RLQALAQAHHHH-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
53 PsiBlast_CBE 61.6745% -81 - C1 -4D2R A:[4-283] ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VPDEW-------EVAREKITMSRELGQGSFGMVYEGV-AKGVVKD--EP-ET-R---VAIKTV--NEAASMRERIEFLNEASVMKEF-NCHHVVRLLGVVSQGQPTLVIMELMTRGDLKSYLRSLRP-------E----M------E--------N--NP-V----LAPPSLSKMIQMAGEIADGMAYLNANKFVHRDLAARNCMV---AED--FTVKIGDFGMTRDIYETDYYRK--KGLLPVRWMSPESLKDGVFTTYSDVWSFGVVLWEIATLAEQPYQGLSNEQVLRFVMEGGLLDKPDNCPDMLFELMRMCWQYNPKMRPSFLEIIS---SIKEEMEPGFREVSFYYSEENK-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
46 PsiBlast_CBE 61.4545% -80 - C1 -2OJ9 A:[9-288] ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VPDEW-------EVAREKITMSRELGQGSFGMVYEGV-AKGVVKD--EP-ET-R---VAIKTV--NEAASMRERIEFLNEASVMKEF-NCHHVVRLLGVVSQGQPTLVIMELMTRGDLKSYLRSLRP-------E---------------------------------PPSLSKMIQMAGEIADGMAYLNANKFVHRDLAARNCMV---AED--FTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMSPESLKDGVFTTYSDVWSFGVVLWEIATLAEQPYQGLSNEQVLRFVMEGGLLDKPDNCPDMLFELMRMCWQYNPKMRPSFLEIIS---SIKEEMEPGFREVSFYYSEENK-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
47 PsiBlast_CBE 61.1245% -85 - C1 -3I81 A:[9-288] ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VPDEW-------EVAREKITMSRELGQGSFGMVYEGV-AKGVVKD--EP-ET-R---VAIKTV--NEAASMRERIEFLNEASVMKEF-NCHHVVRLLGVVSQGQPTLVIMELMTRGDLKSYLRSLRP-------E-----------E--------N--NP-V----LAPPSLSKMIQMAGEIADGMAYLNANKFVHRDLAARNCMV---AED--FTVKIGDFGMTRDIYETDYYR-----LLPVRWMSPESLKDGVFTTYSDVWSFGVVLWEIATLAEQPYQGLSNEQVLRFVMEGGLLDKPDNCPDMLFELMRMCWQYNPKMRPSFLEIIS---SIKEEMEPGFREVSFYYSEENK-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
37 PsiBlast_CBE 60.6743% -88 - C1 -3LVP IGF1R_HUMAN A:[39-317] -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PDEW-------EVAREKITMSRELGQGSFGMVYEGV-AKGVVKD--EP-ET-R---VAIKTV--NEAASMRERIEFLNEASVMKEF-NCHHVVRLLGVVSQGQPTLVIMELMTRGDLKSYLRSLRP-------E----M------E------------P-V----LAPPSLSKMIQMAGEIADGMAYLNANKFVHRDLAARNCMV---AED--FTVKIGDFGMTRDIY-------GGKGLLPVRWMSPESLKDGVFTTYSDVWSFGVVLWEIATLAEQPYQGLSNEQVLRFVMEGGLLDKPDNCPDMLFELMRMCWQYNPKMRPSFLEIIS---SIKEEMEPGFREVSFYYSEENK-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
41 PsiBlast_CBE 60.5745% -80 - C1 -3QQU IGF1R_HUMAN B:[3-282] ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VPDEW-------EVAREKITMSRELGQGSFGMVYEGV-AKGVVKD--EP-ET-R---VAIKTV--NEAASMRERIEFLNEASVMKEF-NCHHVVRLLGVVSQGQPTLVIMELMTRGDLKSYLRSLR------------------------------------------PS-LSKMIQMAGEIADGMAYLNANKFVHRDLAARNCMV---AED--FTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMSPESLKDGVFTTYSDVWSFGVVLWEIATLAEQPYQGLSNEQVLRFVMEGGLLDKPDNCPDMLFELMRMCWQYNPKMRPSFLEIIS---SIKEEMEPGFREVSFYYSEENK-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
36 PsiBlast_CBE 60.2349% -91 - C1 -3ZBF A:[24-306] ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IENLP-------AFPREKLTLRLLLGS---GEVYEGTAVDILGVG--SG-EI-K---VAVKTL--KKGSTDQEKIEFLKEAHLMSKF-NHPNILKQLGVCLLNEPQYIILELMEGGDLLTYLRKARM-------A----T------F--------Y--GP-L----LT---LVDLVDLCVDISKGCVYLERMHFIHRDLAARNCLVSVKDYTSPRIVKIGDFGLARDIY------------LPVRWMAPESLMDGIFTTQSDVWSFGILIWEILTLGHQPYPAHSNLDVLNYVQTGGRLEPPRNCPDDLWNLMTQCWAQEPDQRPTFHRIQD---QLQLFRNFFLNSIYKSR------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
90 PsiBlast_CBE 60.2239% -89 - C1 -4RWK B:[24-307] ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ELPRDRLVLGKPLGEGAFGQVVLAE-AIGLDKDK-PN-RVTK---VAVKML--KSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIMEYASKGNLREYLQARR-----------------------------------Q----LS---SKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVT---ED--NVMKIADFGLA-----IDYYKKT--GRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVE---DLDRIVALTSN------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
56 PsiBlast_CBE 60.1245% -79 - C1 -1I44 A:[9-283] -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PDEW-------EVSREKITLLRELGQGSFGMVYEGN-ARDIIKG--EA-ET-R---VAVKTV--NESASLRERIEFLNEASVMKGF-TCHHVVRLLGVVSKGQPTLVVMELMAHGDLKSYLRSLRP-------EAENNP------G--------R--PP-P-----T---LQEMIQMAAEIADGMAYLNAKKFVHRDLAARNCMV---AHD--FTVKIGDFGMT----------------LPVRWMAPESLKDGVFTTSSDMWSFGVVLWEITSLAEQPYQGLSNEQVLKFVMDGGYLDQPDNCPERVTDLMRMCWQFNPKMRPTFLEIVN---LLKDDLHPSFPEVSFFHSEENK-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
70 PsiBlast_CBE 60.0441% -84 - C1 -4PMT A:[2-286] ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VH-------HIKRRDIVLKWELGEGAFGKVFLAE-CHNL------D-KM-L---VAVKAL------------DFQREAELLTML-QHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGP-------D----A------KLLAGGEDVA--PG-P----LG---LGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLV---GQG--LVVKIGDF--SRDIYSTDYYRV---TMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHA---RLQALAQAHHHH-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------