@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : AMHR2_HUMAN: (2015-10-03 )
MLGSLGLWALLPTAVEAPPNRRTCVFFEAPGVRGSTKTLGELLDTGTELPRAIRCLYSRCCFGIWNLTQDRAQVEMQGCRDSDEPGCESLHCDPSPRAHPSPGSTLFTCSCGTDFCNANYSHLPPPGSPGTPGSQGPQAAPGESIWMALVLLGLFLLLLLLLGSIILALLQRKNYRVRGEPVPEPRPDSGRDWSVELQELPELCFSQVIREGGHAVVWAGQLQGKLVAIKAFPPRSVAQFQAERALYELPGLQHDHIVRFITASRGGPGRLLSGPLLVLELHPKGSLCHYLTQYTSDWGSSLRMALSLAQGLAFLHEERWQNGQYKPGIAHRDLSSQNVLIREDGSCAIGDLGLALVLPGLTQPPAWTPTQPQGPAAIMEAGTQRYMAPELLDKTLDLQDWGMALRRADIYSLALLLWEILSRCPDLRPDSSPPPFQLAYEAELGNTPTSDELWALAVQERRRPYIPSTWRCFATDPDGLRELLEDCWDADPEARLTAECVQQRLAALAHPQESHPFPESCPRGCPPLCPEDCTSIPAPTILPCRPQRSACHFSVQQGPCSRNPQPACTLSPV
Atome Classification :
(32 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190....---...200.......210.......220.......230.......240.......250.......260.---......270.......280.......290.......300.......310......--.-320..-.....330.......340.......350......-.360.......370.......380.......390.......400.......410.......420....--...430.......440.......450.......460.......470......--..480---.---......490.......500.......510.......520.......530.......540.......550.......560.......570.
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MLGS
L
G
L
W
A
LL
P
T
A
VEAPPNR
R
T
C
V
F
F
EAPGVRG
S
T
K
T
L
G
E
L
L
DTGTE
L
P
R
A
I
R
C
L
Y
S
R
C
C
F
G
I
WNLT
Q
D
R
A
Q
V
E
M
QGCRDSDEPGCESLHCDPSPRAHPSPG
S
T
L
F
T
CSCGTDFCNANYSHLPPPGSPGTPGSQGPQAAP
G
E
S
I
W
M
A
L
V
L
L
G
L
F
L
L
L
L
L
L
L
G
S
I
I
L
A
L
L
Q
RKN
Y
R
VRGEPVPEPRPDSGRD
W
S
V
E
---
L
Q
E
L
P
E
L
C
F
S
Q
V
I
R
EGG
H
A
V
V
W
AGQLQ
G
K
L
V
A
I
K
AFP
P
R
S
V
A
Q
F
Q
A
E
R
A
L
Y
ELPGL
Q
H
D
H
I
V
R
F
I
TA---SRGGPGRLLSG
P
L
L
V
L
E
LHPK
G
S
L
C
H
Y
L
T
Q
Y
T
S
D
W
G
S
S
L
R
M
A
L
S
L
A
Q
G
L
A
F
L
H
E
E
--
R
-WQNGQ-YKPGIAHRDLSSQ
N
V
L
I
REDGSC
A
I
G
D
L
G
L
A
L
VL-PGLTQPPAWTPTQPQG
P
A
A
I
M
E
AGTQRYM
A
P
E
L
L
D
K
TL
D
L
Q
D
W
G
M
A
L
R
R
A
D
I
Y
S
L
A
L
L
L
W
E
I
L
S
RCPD--LRPDSSPP
P
F
Q
L
A
Y
E
AELGNTPT
S
D
E
L
W
A
L
A
V
Q
ERRRPYIPS
T
W
R
-
C
FAT
D
P
--
D
G
L
R
E
---
L
---
L
E
D
C
WDADP
E
A
R
L
T
A
E
C
V
Q
Q
R
L
A
A
LAHPQESHPFPESCPRGCPPL
C
P
E
D
CTSIPAPTILPCRPQRS
A
C
H
F
SVQQGPCSRNPQPACTLSPV
42
PsiBlast_CBE
94.39
33%
-102
- C2 -
4X2J
1
TGFR1_HUMAN
A:
[7-301]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
L
Q
E
S
I
G
K
G
R
F
G
E
V
W
R
G
K
W
R
G
E
E
V
A
V
K
I
F
S
S
R
E
E
R
S
W
F
R
E
A
E
I
Y
Q
T
V
M
L
R
H
E
N
I
L
G
F
I
A
A
---
D
N
K
D
N
G
-
T
W
T
Q
L
W
L
V
S
D
Y
H
E
H
G
S
L
F
D
Y
L
N
R
Y
T
V
T
V
E
G
M
I
K
L
A
L
S
T
A
S
G
L
A
H
L
H
M
E
--
I
--
V
G
T
Q
-
G
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
T
C
C
I
A
D
L
G
L
A
V
R
H
-
D
S
A
T
D
T
I
D
I
A
P
N
H
--------
R
V
G
T
K
R
Y
M
A
P
E
V
L
D
D
S
I
N
M
K
H
F
E
-
S
F
K
R
A
D
I
Y
A
M
G
L
V
F
W
E
I
A
R
R
C
S
-----
I
G
G
I
H
E
D
Y
Q
L
P
Y
Y
D
L
V
P
S
D
P
S
V
E
E
M
R
K
V
V
C
E
Q
K
L
R
P
N
I
P
N
R
W
Q
S
C
E
A
L
R
V
----
M
A
K
---
I
---
M
R
E
C
W
Y
A
N
G
A
A
R
L
T
A
L
R
I
K
K
T
L
S
Q
L
S
Q
Q
E
G
I
-----------------------------------------------------------
41
PsiBlast_CBE
94.39
33%
-102
- C2 -
4X2K
1
TGFR1_HUMAN
A:
[7-301]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
L
Q
E
S
I
G
K
G
R
F
G
E
V
W
R
G
K
W
R
G
E
E
V
A
V
K
I
F
S
S
R
E
E
R
S
W
F
R
E
A
E
I
Y
Q
T
V
M
L
R
H
E
N
I
L
G
F
I
A
A
---
D
N
K
D
N
G
-
T
W
T
Q
L
W
L
V
S
D
Y
H
E
H
G
S
L
F
D
Y
L
N
R
Y
T
V
T
V
E
G
M
I
K
L
A
L
S
T
A
S
G
L
A
H
L
H
M
E
--
I
--
V
G
T
Q
-
G
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
T
C
C
I
A
D
L
G
L
A
V
R
H
-
D
S
A
T
D
T
I
D
I
A
P
N
H
--------
R
V
G
T
K
R
Y
M
A
P
E
V
L
D
D
S
I
N
M
K
H
F
E
-
S
F
K
R
A
D
I
Y
A
M
G
L
V
F
W
E
I
A
R
R
C
S
-----
I
G
G
I
H
E
D
Y
Q
L
P
Y
Y
D
L
V
P
S
D
P
S
V
E
E
M
R
K
V
V
C
E
Q
K
L
R
P
N
I
P
N
R
W
Q
S
C
E
A
L
R
V
----
M
A
K
---
I
---
M
R
E
C
W
Y
A
N
G
A
A
R
L
T
A
L
R
I
K
K
T
L
S
Q
L
S
Q
Q
E
G
I
-----------------------------------------------------------
11
PsiBlast_PDB
94.37
33%
-104
- C2 -
4X2G
2
?
A:
[7-301]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
L
Q
E
S
I
G
K
G
R
F
G
E
V
W
R
G
K
W
R
G
E
E
V
A
V
K
I
F
S
S
R
E
E
R
S
W
F
R
E
A
E
I
Y
Q
T
V
M
L
R
H
E
N
I
L
G
F
I
A
A
---
D
N
K
D
N
G
-
T
W
T
Q
L
W
L
V
S
D
Y
H
E
H
G
S
L
F
D
Y
L
N
R
Y
T
V
T
V
E
G
M
I
K
L
A
L
S
T
A
S
G
L
A
H
L
H
M
E
--
I
--
V
G
T
Q
-
G
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
T
C
C
I
A
D
L
G
L
A
V
R
H
-
D
S
A
T
D
T
I
D
I
A
P
N
H
--------
R
V
G
T
K
R
Y
M
A
P
E
V
L
D
D
S
I
N
M
K
H
F
E
-
S
F
K
R
A
D
I
Y
A
M
G
L
V
F
W
E
I
A
R
R
C
S
-----
I
G
G
I
H
E
D
Y
Q
L
P
Y
Y
D
L
V
P
S
D
P
S
V
E
E
M
R
K
V
V
C
E
Q
K
L
R
P
N
I
P
N
R
W
Q
S
C
E
A
L
R
V
----
M
A
K
---
I
---
M
R
E
C
W
Y
A
N
G
A
A
R
L
T
A
L
R
I
K
K
T
L
S
Q
L
S
Q
Q
E
G
I
-----------------------------------------------------------
43
PsiBlast_CBE
93.03
33%
-103
- C2 -
4X0M
1
TGFR1_HUMAN
A:
[7-301]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
L
Q
E
S
I
G
K
G
R
F
G
E
V
W
R
G
K
W
R
G
E
E
V
A
V
K
I
F
S
S
R
E
E
R
S
W
F
R
E
A
E
I
Y
Q
T
V
M
L
R
H
E
N
I
L
G
F
I
A
A
---
D
N
K
D
N
G
-
T
W
T
Q
L
W
L
V
S
D
Y
H
E
H
G
S
L
F
D
Y
L
N
R
Y
T
V
T
V
E
G
M
I
K
L
A
L
S
T
A
S
G
L
A
H
L
H
M
E
--
I
--
V
G
T
Q
-
G
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
T
C
C
I
A
D
L
G
L
A
V
R
H
-
D
S
A
T
D
T
I
D
I
A
P
N
H
--------
R
V
G
T
K
R
Y
M
A
P
E
V
L
D
D
S
I
N
M
K
H
F
E
-
S
F
K
R
A
D
I
Y
A
M
G
L
V
F
W
E
I
A
R
R
C
S
-----
I
G
G
I
H
E
D
Y
Q
L
P
Y
Y
D
L
V
P
S
D
P
S
V
E
E
M
R
K
V
V
C
E
Q
K
L
R
P
N
I
P
N
R
W
Q
S
C
E
A
L
R
V
----
M
A
K
---
I
---
M
R
E
C
W
Y
A
N
G
A
A
R
L
T
A
L
R
I
K
K
T
L
S
Q
L
S
Q
Q
E
G
I
-----------------------------------------------------------
15
PsiBlast_PDB
92.51
33%
-108
- C2 -
3HMM
1
TGFR1_HUMAN
A:
[5-298]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
L
Q
E
S
I
G
K
G
R
F
G
E
V
W
R
G
K
W
R
G
E
E
V
A
V
K
I
F
S
S
R
E
E
R
S
W
F
R
E
A
E
I
Y
Q
T
V
M
L
R
H
E
N
I
L
G
F
I
A
A
---
D
N
K
D
N
G
-
T
W
T
Q
L
W
L
V
S
D
Y
H
E
H
G
S
L
F
D
Y
L
N
R
Y
T
V
T
V
E
G
M
I
K
L
A
L
S
T
A
S
G
L
A
H
L
H
M
E
--
I
--
V
G
T
Q
-
G
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
T
C
C
I
A
D
L
G
L
A
V
R
H
-
D
S
A
T
D
T
I
D
I
A
-------------
G
T
K
R
Y
M
A
P
E
V
L
D
D
S
I
N
M
K
H
F
E
-
S
F
K
R
A
D
I
Y
A
M
G
L
V
F
W
E
I
A
R
R
C
S
-----
I
G
G
I
H
E
D
Y
Q
L
P
Y
Y
D
L
V
P
S
D
P
S
V
E
E
M
R
K
V
V
C
E
Q
K
L
R
P
N
I
P
N
R
W
Q
S
C
E
A
L
R
V
----
M
A
K
---
I
---
M
R
E
C
W
Y
A
N
G
A
A
R
L
T
A
L
R
I
K
K
T
L
S
Q
L
S
Q
Q
--------------------------------------------------------------
12
PsiBlast_PDB
92.01
33%
-100
- C2 -
2WOT
2
TGFR1_HUMAN
A:
[8-302]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
L
Q
E
S
I
G
K
G
R
F
G
E
V
W
R
G
K
W
R
G
E
E
V
A
V
K
I
F
S
S
R
E
E
R
S
W
F
R
E
A
E
I
Y
Q
T
V
M
L
R
H
E
N
I
L
G
F
I
A
A
---
D
N
K
D
N
G
-
T
W
T
Q
L
W
L
V
S
D
Y
H
E
H
G
S
L
F
D
Y
L
N
R
Y
T
V
T
V
E
G
M
I
K
L
A
L
S
T
A
S
G
L
A
H
L
H
M
E
--
I
--
V
G
T
Q
-
G
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
T
C
C
I
A
D
L
G
L
A
V
R
H
-
D
S
A
T
D
T
I
D
I
A
P
N
H
--------
R
V
G
T
K
R
Y
M
A
P
E
V
L
D
D
S
I
N
M
K
H
F
E
-
S
F
K
R
A
D
I
Y
A
M
G
L
V
F
W
E
I
A
R
R
C
S
-----
I
G
G
I
H
E
D
Y
Q
L
P
Y
Y
D
L
V
P
S
D
P
S
V
E
E
M
R
K
V
V
C
E
Q
K
L
R
P
N
I
P
N
R
W
Q
S
C
E
A
L
R
V
----
M
A
K
---
I
---
M
R
E
C
W
Y
A
N
G
A
A
R
L
T
A
L
R
I
K
K
T
L
S
Q
L
S
Q
Q
E
G
------------------------------------------------------------
9
PsiBlast_PDB
91.62
33%
-105
- C2 -
3TZM
1
TGFR1_HUMAN
A:
[11-302]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
L
Q
E
S
I
G
K
G
R
F
G
E
V
W
R
G
K
W
R
G
E
E
V
A
V
K
I
F
S
S
R
E
E
R
S
W
F
R
E
A
E
I
Y
Q
T
V
M
L
R
H
E
N
I
L
G
F
I
A
A
---
D
N
K
D
N
G
-
T
W
T
Q
L
W
L
V
S
D
Y
H
E
H
G
S
L
F
D
Y
L
N
R
Y
T
V
T
V
E
G
M
I
K
L
A
L
S
T
A
S
G
L
A
H
L
H
M
E
--
I
--
V
G
T
Q
-
G
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
T
C
C
I
A
D
L
G
L
A
V
R
H
-
D
S
A
T
D
T
I
D
I
A
P
----------
R
V
G
T
K
R
Y
M
A
P
E
V
L
D
D
S
I
N
M
K
H
F
E
-
S
F
K
R
A
D
I
Y
A
M
G
L
V
F
W
E
I
A
R
R
C
S
-----
I
G
G
I
H
E
D
Y
Q
L
P
Y
Y
D
L
V
P
S
D
P
S
V
E
E
M
R
K
V
V
C
E
Q
K
L
R
P
N
I
P
N
R
W
Q
S
C
E
A
L
R
V
----
M
A
K
---
I
---
M
R
E
C
W
Y
A
N
G
A
A
R
L
T
A
L
R
I
K
K
T
L
S
Q
L
S
----------------------------------------------------------------
13
PsiBlast_PDB
90.87
33%
-105
- C2 -
2WOU
2
TGFR1_HUMAN
A:
[8-299]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
L
Q
E
S
I
G
K
G
R
F
G
E
V
W
R
G
K
W
R
G
E
E
V
A
V
K
I
F
S
S
R
E
E
R
S
W
F
R
E
A
E
I
Y
Q
T
V
M
L
R
H
E
N
I
L
G
F
I
A
A
---
D
N
K
D
N
G
-
T
W
T
Q
L
W
L
V
S
D
Y
H
E
H
G
S
L
F
D
Y
L
N
R
Y
T
V
T
V
E
G
M
I
K
L
A
L
S
T
A
S
G
L
A
H
L
H
M
E
--
I
--
V
G
T
Q
-
G
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
T
C
C
I
A
D
L
G
L
A
V
R
H
-
D
S
A
T
D
T
I
D
I
A
P
N
H
--------
R
V
G
T
K
R
Y
M
A
P
E
V
L
D
D
S
I
N
M
K
H
F
E
-
S
F
K
R
A
D
I
Y
A
M
G
L
V
F
W
E
I
A
R
R
C
S
-----
I
G
G
I
H
E
D
Y
Q
L
P
Y
Y
D
L
V
P
S
D
P
S
V
E
E
M
R
K
V
V
C
E
Q
K
L
R
P
N
I
P
N
R
W
Q
S
C
E
A
L
R
V
----
M
A
K
---
I
---
M
R
E
C
W
Y
A
N
G
A
A
R
L
T
A
L
R
I
K
K
T
L
S
Q
L
S
----------------------------------------------------------------
16
PsiBlast_PDB
90.25
34%
-107
- C2 -
3H9R
4
ACVR1_HUMAN
A:
[38-329]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
I
T
L
L
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
S
W
Q
G
E
N
V
A
V
K
I
F
S
S
R
D
E
K
S
W
F
R
E
T
E
L
Y
N
T
V
M
L
R
H
E
N
I
L
G
F
I
A
S
D
M
T
S
---
S
T
Q
L
W
----
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
Q
L
T
T
L
D
T
V
S
C
L
R
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
--
I
-
F
-
G
T
Q
-
G
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
-
V
M
-
H
-------------
R
-------
V
G
T
K
R
Y
M
A
P
E
V
L
D
E
T
I
Q
V
-
D
C
F
D
S
Y
K
R
V
D
I
W
A
F
G
L
V
L
W
E
V
A
R
R
M
V
S
NG
I
V
E
D
Y
K
P
P
F
Y
D
V
-----
V
P
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
N
I
P
N
R
W
----
F
S
D
P
T
L
T
S
L
A
K
---
L
---
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
L
R
I
K
K
T
L
T
K
I
D
----------------------------------------------------------------
44
PsiBlast_CBE
89.64
34%
-101
- C2 -
4BGG
1
ACVR1_HUMAN
D:
[9-300]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
I
T
L
L
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
S
W
Q
G
E
N
V
A
V
K
I
F
S
S
R
D
E
K
S
W
F
R
E
T
E
L
Y
N
T
V
M
L
R
H
E
N
I
L
G
F
I
A
S
D
M
T------
Q
L
W
----
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
Q
L
T
T
L
D
T
V
S
C
L
R
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
--
I
-
F
-
G
----
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
V
M
H
-
S
Q
S
T
N
Q
L
D
-
V
G
N
N
P
R
-------
V
G
T
K
R
Y
M
A
P
E
V
L
D
E
T
I
Q
V
-
D
C
F
D
S
Y
K
R
V
D
I
W
A
F
G
L
V
L
W
E
V
A
R
R
M
V
S
NG
I
V
E
D
Y
K
P
P
F
Y
D
V
-----
V
P
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
N
I
P
N
R
W
----
F
S
D
P
T
L
T
S
L
A
K
---
L
---
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
L
R
I
K
K
T
L
T
K
I
-----------------------------------------------------------------
10
PsiBlast_PDB
89.16
33%
-97
- C2 -
1PY5
1
TGFR1_HUMAN
A:
[31-325]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
L
Q
E
S
I
G
K
G
R
F
G
E
V
W
R
G
K
W
R
G
E
E
V
A
V
K
I
F
S
S
R
E
E
R
S
W
F
R
E
A
E
I
Y
Q
T
V
M
L
R
H
E
N
I
L
G
F
I
A
A
---
D
N
K
D
N
G
-
T
W
T
Q
L
W
L
V
S
D
Y
H
E
H
G
S
L
F
D
Y
L
N
R
Y
T
V
T
V
E
G
M
I
K
L
A
L
S
T
A
S
G
L
A
H
L
H
M
E
----
I
V
G
T
Q
-
G
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
T
C
C
I
A
D
L
G
L
A
V
R
H
-
D
S
A
T
D
T
I
D
I
A
P
N
H
--------
R
V
G
T
K
R
Y
M
A
P
E
V
L
D
D
S
I
N
M
K
H
F
E
-
S
F
K
R
A
D
I
Y
A
M
G
L
V
F
W
E
I
A
R
R
C
S
-----
I
G
G
I
H
E
D
Y
Q
L
P
Y
Y
D
L
V
P
S
D
P
S
V
E
E
M
R
K
V
V
C
E
Q
K
L
R
P
N
I
P
N
R
W
Q
S
C
E
A
L
R
V
----
M
A
K
---
I
---
M
R
E
C
W
Y
A
N
G
A
A
R
L
T
A
L
R
I
K
K
T
L
S
Q
L
S
Q
Q
E
G
------------------------------------------------------------
45
PsiBlast_CBE
88.55
34%
-102
- C2 -
4BGG
1
ACVR1_HUMAN
C:
[9-299]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
I
T
L
L
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
S
W
Q
G
E
N
V
A
V
K
I
F
S
S
R
D
E
K
S
W
F
R
E
T
E
L
Y
N
T
V
M
L
R
H
E
N
I
L
G
F
I
A
S
D
M
T
S
R
H
S
S
T
Q
L
W
----
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
Q
L
T
T
L
D
T
V
S
C
L
R
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
--
I
-------
G
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
V
M
H
-
S
Q
S
T
N
----
V
G
N
N
P
R
-------
V
G
T
K
R
Y
M
A
P
E
V
L
D
E
T
I
Q
V
-
D
C
F
D
S
Y
K
R
V
D
I
W
A
F
G
L
V
L
W
E
V
A
R
--------
E
D
Y
K
P
P
F
Y
D
V
-----
V
P
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
N
I
P
N
R
W
----
F
S
D
P
T
L
T
S
L
A
K
---
L
---
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
L
R
I
K
K
T
L
T
K
------------------------------------------------------------------
8
PsiBlast_PDB
88.34
33%
-97
- C2 -
1RW8
1
TGFR1_HUMAN
A:
[6-300]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
L
Q
E
S
I
G
K
G
R
F
G
E
V
W
R
G
K
W
R
G
E
E
V
A
V
K
I
F
S
S
R
E
E
R
S
W
F
R
E
A
E
I
Y
Q
T
V
M
L
R
H
E
N
I
L
G
F
I
A
A
---
D
N
K
D
N
G
-
T
W
T
Q
L
W
L
V
S
D
Y
H
E
H
G
S
L
F
D
Y
L
N
R
Y
T
V
T
V
E
G
M
I
K
L
A
L
S
T
A
S
G
L
A
H
L
H
M
E
--
I
--
V
G
T
Q
-
G
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
T
C
C
I
A
D
L
G
L
A
V
R
H
-
D
S
A
T
D
T
I
D
I
A
P
N
H
--------
R
V
G
T
K
R
Y
M
A
P
E
V
L
D
D
S
I
N
M
K
H
F
E
-
S
F
K
R
A
D
I
Y
A
M
G
L
V
F
W
E
I
A
R
R
C
S
-----
I
G
G
I
H
E
D
Y
Q
L
P
Y
Y
D
L
V
P
S
D
P
S
V
E
E
M
R
K
V
V
C
E
Q
K
L
R
P
N
I
P
N
R
W
Q
S
C
E
A
L
R
V
----
M
A
K
---
I
---
M
R
E
C
W
Y
A
N
G
A
A
R
L
T
A
L
R
I
K
K
T
L
S
Q
L
S
Q
Q
E
G
------------------------------------------------------------
14
PsiBlast_PDB
88.17
33%
-103
- C2 -
3GXL
1
TGFR1_HUMAN
A:
[5-298]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
L
Q
E
S
I
G
K
G
R
F
G
E
V
W
R
G
K
W
---
E
V
A
V
K
I
F
S
S
R
E
E
R
S
W
F
R
E
A
E
I
Y
Q
T
V
M
L
R
H
E
N
I
L
G
F
I
A
A
---
D
N
K
D
N
G
-
T
W
T
Q
L
W
L
V
S
D
Y
H
E
H
G
S
L
F
D
Y
L
N
R
Y
T
V
T
V
E
G
M
I
K
L
A
L
S
T
A
S
G
L
A
H
L
H
M
E
--
I
--
V
G
T
Q
-
G
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
T
C
C
I
A
D
L
G
L
A
V
R
H
-
D
S
A
T
D
T
I
D
-------------
R
V
G
T
K
R
Y
M
A
P
E
V
L
D
D
S
I
N
M
K
H
F
E
-
S
F
K
R
A
D
I
Y
A
M
G
L
V
F
W
E
I
A
R
R
C
S
-----
I
---
H
E
D
Y
Q
L
P
Y
Y
D
L
V
P
S
D
P
S
V
E
E
M
R
K
V
V
C
E
Q
K
L
R
P
N
I
P
N
R
--S
C
E
A
L
R
V
----
M
A
K
---
I
---
M
R
E
C
W
Y
A
N
G
A
A
R
L
T
A
L
R
I
K
K
T
L
S
Q
L
S
Q
Q
--------------------------------------------------------------
2
PsiBlast_PDB
88.11
34%
-96
- C2 -
3Q4T
14
AVR2A_HUMAN
A:
[14-316]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
T
E
N
L
Y
F
Q
S
M
P
-
L
Q
L
L
E
V
K
A
R
G
R
F
G
C
V
W
K
A
Q
L
L
N
E
Y
V
A
V
K
I
F
P
I
Q
D
K
Q
S
W
Q
N
E
Y
E
V
Y
S
L
P
G
M
K
H
E
N
I
L
Q
F
I
G
A
---
E
K
R
G
T
S
V
D
V
D
-
L
W
L
I
T
A
F
H
E
K
G
S
L
S
D
F
L
K
A
N
V
V
S
W
N
E
L
C
H
I
A
E
T
M
A
R
G
L
A
Y
L
H
E
D
I
P
G
-
L
K
D
G
--
H
K
P
A
I
S
H
R
D
I
K
S
K
N
V
L
L
K
N
N
L
T
A
C
I
A
D
F
G
L
A
L
K
F
-
E
A
---
G
K
S
A
G
D
T
H
G
Q
-------
V
G
T
R
R
Y
M
A
P
E
V
L
E
G
A
I
N
F
Q
R
--
D
A
F
L
R
I
D
M
Y
A
M
G
L
V
L
W
E
L
A
S
R
C
T
----
A
A
D
G
P
V
D
E
Y
M
L
P
F
E
E
E
I
G
Q
H
P
S
L
E
D
M
Q
E
V
V
V
H
K
K
K
R
P
V
L
R
D
Y
W
Q
-
K
H
A
G
M
A
---
M
L
C
E
---
T
---
I
E
E
C
W
D
H
D
A
E
A
R
L
S
A
G
C
V
G
E
R
I
T
Q
M
Q
R
---------------------------------------------------------------
23
PsiBlast_CBE
87.71
34%
-98
- C2 -
3Q4T
11
AVR2A_HUMAN
B:
[10-316]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
G
V
D
L
G
T
E
N
L
Y
F
Q
S
M
P
-
L
Q
L
L
E
V
K
A
R
G
R
F
G
C
V
W
K
A
Q
L
L
N
E
Y
V
A
V
K
I
F
P
I
Q
D
K
Q
S
W
Q
N
E
Y
E
V
Y
S
L
P
G
M
K
H
E
N
I
L
Q
F
I
G
A
---
E
K
R
G
T
S
V
D
V
D
-
L
W
L
I
T
A
F
H
E
K
G
S
L
S
D
F
L
K
A
N
V
V
S
W
N
E
L
C
H
I
A
E
T
M
A
R
G
L
A
Y
L
H
E
D
IP
G
-
L
K
D
G
--
H
K
P
A
I
S
H
R
D
I
K
S
K
N
V
L
L
K
N
N
L
T
A
C
I
A
D
F
G
L
A
L
K
F
-
E
A
---
G
K
S
A
--
T
H
G
Q
-------
V
G
T
R
R
Y
M
A
P
E
V
L
E
G
A
I
N
F
Q
R
--
D
A
F
L
R
I
D
M
Y
A
M
G
L
V
L
W
E
L
A
S
R
C
T
----
A
A
D
G
P
V
D
E
Y
M
L
P
F
E
E
E
I
G
Q
H
P
S
L
E
D
M
Q
E
V
V
V
H
K
K
K
R
P
V
L
R
D
Y
W
Q
-
K
H
A
G
M
A
---
M
L
C
E
---
T
---
I
E
E
C
W
D
H
D
A
E
A
R
L
S
A
G
C
V
G
E
R
I
T
Q
M
Q
R
L
--------------------------------------------------------------
47
PsiBlast_CBE
87.63
34%
-101
- C2 -
4BGG
2
ACVR1_HUMAN
A:
[9-300]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
I
T
L
L
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
S
W
Q
G
E
N
V
A
V
K
I
F
S
S
R
D
E
K
S
W
F
R
E
T
E
L
Y
N
T
V
M
L
R
H
E
N
I
L
G
F
I
A
S
D
M
T
S
R
H
S
S
T
Q
L
W
----
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
Q
L
T
T
L
D
T
V
S
C
L
R
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
--
I
-
F
-
G
T
Q
-
G
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
V
M
H
-
S
Q
S
T
N
Q
L
D
-
V
G
N
N
P
R
-------
V
G
T
K
R
Y
M
A
P
E
V
L
D
E
T
I
Q
V
-
D
C
F
D
S
Y
K
R
V
D
I
W
A
F
G
L
V
L
W
E
V
A
R
R
M
V
S
NG
I
V
E
D
Y
K
P
P
F
Y
D
V
-----
V
P
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
N
I
P
N
R
W
----
F
S
D
P
T
L
T
S
L
A
K
---
L
---
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
L
R
I
K
K
T
L
T
K
I
-----------------------------------------------------------------
46
PsiBlast_CBE
87.63
34%
-101
- C2 -
4BGG
1
ACVR1_HUMAN
B:
[9-300]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
I
T
L
L
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
S
W
Q
G
E
N
V
A
V
K
I
F
S
S
R
D
E
K
S
W
F
R
E
T
E
L
Y
N
T
V
M
L
R
H
E
N
I
L
G
F
I
A
S
D
M
T
S
R
H
S
S
T
Q
L
W
----
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
Q
L
T
T
L
D
T
V
S
C
L
R
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
--
I
-
F
-
G
----
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
V
M
H
-
S
Q
S
T
N
Q
L
D
-
V
G
N
N
P
R
-------
V
G
T
K
R
Y
M
A
P
E
V
L
D
E
T
I
Q
V
-
D
C
F
D
S
Y
K
R
V
D
I
W
A
F
G
L
V
L
W
E
V
A
R
R
M
V
S
NG
I
V
E
D
Y
K
P
P
F
Y
D
V
-----
V
P
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
N
I
P
N
R
W
----
F
S
D
P
T
L
T
S
L
A
K
---
L
---
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
L
R
I
K
K
T
L
T
K
I
-----------------------------------------------------------------
21
PsiBlast_CBE
87.33
34%
-97
- C2 -
4ASX
6
AVR2A_HUMAN
B:
[14-316]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
T
E
N
L
Y
F
Q
S
M
P
-
L
Q
L
L
E
V
K
A
R
G
R
F
G
C
V
W
K
A
Q
L
L
N
E
Y
V
A
V
K
I
F
P
I
Q
D
K
Q
S
W
Q
N
E
Y
E
V
Y
S
L
P
G
M
K
H
E
N
I
L
Q
F
I
G
A
---
E
K
R
G
T
S
V
D
V
D
-
L
W
L
I
T
A
F
H
E
K
G
S
L
S
D
F
L
K
A
N
V
V
S
W
N
E
L
C
H
I
A
E
T
M
A
R
G
L
A
Y
L
H
E
D
I
P
G
-
L
K
D
G
--
H
K
P
A
I
S
H
R
D
I
K
S
K
N
V
L
L
K
N
N
L
T
A
C
I
A
D
F
G
L
A
L
K
F
-
E
A
---
G
K
S
A
G
D
T
H
G
Q
-------
V
G
T
R
R
Y
M
A
P
E
V
L
E
G
A
I
N
F
Q
R
--
D
A
F
L
R
I
D
M
Y
A
M
G
L
V
L
W
E
L
A
S
R
C
T
----
A
A
D
G
P
V
D
E
Y
M
L
P
F
E
E
E
I
G
Q
H
P
S
L
E
D
M
Q
E
V
V
V
H
K
K
K
R
P
V
L
R
D
Y
W
Q
-
K
H
A
G
M
A
---
M
L
C
E
---
T
---
I
E
E
C
W
D
H
D
A
E
A
R
L
S
A
G
C
V
G
E
R
I
T
Q
M
Q
R
L
T
-------------------------------------------------------------
90
HHSearch
86.92
34%
-96
- C2 -
3MDY
1
BMR1B_HUMAN
A:
[37-333]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
Q
I
Q
M
V
K
Q
I
G
K
G
R
Y
G
E
V
W
M
G
K
W
R
G
E
K
V
A
V
K
V
F
F
T
T
E
E
A
S
W
F
R
E
T
E
I
Y
Q
T
V
L
M
R
H
E
N
I
L
G
F
I
A
A
---
D
I
K
G
T
G
S
-
W
T
Q
L
Y
L
I
T
D
Y
H
E
N
G
S
L
Y
D
Y
L
K
S
T
T
L
D
A
K
S
M
L
K
L
A
Y
S
S
V
S
G
L
C
H
L
H
T
E
--
I
-
F
-
S
T
Q
-
G
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
T
C
C
I
A
D
L
G
L
A
V
K
F
-
I
-----------------
P
N
T
R
V
G
T
K
R
Y
M
P
P
E
V
L
D
E
S
L
N
R
N
H
F
Q
S
Y
-
I
M
A
D
M
Y
S
F
G
L
I
L
W
E
V
A
R
R
C
V
-----
S
G
G
I
V
E
E
Y
Q
L
P
Y
H
D
L
V
P
S
D
P
S
Y
E
D
M
R
E
I
V
C
I
K
K
L
R
P
S
F
P
N
R
W
S
-
S
-
D
E
C
L
--
R
Q
M
G
K
---
L
---
M
T
E
C
W
A
H
N
P
A
S
R
L
T
A
L
R
V
K
K
T
L
A
K
M
S
E
S
Q
D
I
K
L
---------------------------------------------------------
22
PsiBlast_CBE
86.88
34%
-98
- C2 -
3SOC
6
AVR2A_HUMAN
B:
[10-316]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
G
V
D
L
G
T
E
N
L
Y
F
Q
S
M
P
-
L
Q
L
L
E
V
K
A
R
G
R
F
G
C
V
W
K
A
Q
L
L
N
E
Y
V
A
V
K
I
F
P
I
Q
D
K
Q
S
W
Q
N
E
Y
E
V
Y
S
L
P
G
M
K
H
E
N
I
L
Q
F
I
G
A
---
E
K
R
G
T
S
V
D
V
D
-
L
W
L
I
T
A
F
H
E
K
G
S
L
S
D
F
L
K
A
N
V
V
S
W
N
E
L
C
H
I
A
E
T
M
A
R
G
L
A
Y
L
H
E
D
I
P
G
-
L
K
D
G
--
H
K
P
A
I
S
H
R
D
I
K
S
K
N
V
L
L
K
N
N
L
T
A
C
I
A
D
F
G
L
A
L
K
F
-
E
A
---
G
K
S
A
--
T
H
G
Q
-------
V
G
T
R
R
Y
M
A
P
E
V
L
E
G
A
I
N
F
Q
R
--
D
A
F
L
R
I
D
M
Y
A
M
G
L
V
L
W
E
L
A
S
R
C
T
----
A
A
D
G
P
V
D
E
Y
M
L
P
F
E
E
E
I
G
Q
H
P
S
L
E
D
M
Q
E
V
V
V
H
K
K
K
R
P
V
L
R
D
Y
W
Q
-
K
H
A
G
M
A
---
M
L
C
E
---
T
---
I
E
E
C
W
D
H
D
A
E
A
R
L
S
A
G
C
V
G
E
R
I
T
Q
M
Q
R
L
T
-------------------------------------------------------------
1
PsiBlast_PDB
86.88
35%
-94
- C2 -
2QLU
1
AVR2B_HUMAN
A:
[21-308]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
K
A
R
G
R
F
G
C
V
W
K
A
Q
L
M
N
D
F
V
A
V
K
I
F
P
L
Q
D
K
Q
S
W
Q
S
E
R
E
I
F
S
T
P
G
M
K
H
E
N
L
L
Q
F
I
A
A
---
E
K
R
G
S
N
-
L
E
V
E
L
W
L
I
T
A
F
H
D
K
G
S
L
T
D
Y
L
K
G
N
I
I
T
W
N
E
L
C
H
V
A
E
T
M
S
R
G
L
S
Y
L
H
E
D
--
V
P
W
C
R
G
E
G
H
K
P
S
I
A
H
R
D
F
K
S
K
N
V
L
L
K
S
D
L
T
A
V
L
A
D
F
G
L
A
V
R
F
E
P
G
--
K
P
P
G
D
T
H
G
Q
---------
V
G
T
R
R
Y
M
A
P
E
V
L
E
G
A
I
N
F
Q
R
--
D
A
F
L
R
I
D
M
Y
A
M
G
L
V
L
W
E
L
V
S
R
C
K
----
A
A
D
G
P
V
D
E
Y
M
L
P
F
E
E
E
I
G
Q
H
P
S
L
E
E
L
Q
E
V
V
V
H
K
K
M
R
P
T
I
K
D
H
W
-----
L
K
H
--
P
G
L
A
Q
---
L
C
V
T
I
E
E
C
W
D
H
D
A
E
A
R
L
S
A
G
C
V
E
E
R
V
S
L
I
R
R
S
--------------------------------------------------------------
17
PsiBlast_PDB
86.80
34%
-104
- C2 -
4C02
10
ACVR1_HUMAN
A:
[38-329]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
I
T
L
L
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
S
W
Q
G
E
N
V
A
V
K
I
F
S
S
R
D
E
K
S
W
F
R
E
T
E
L
Y
N
T
V
M
L
R
H
E
N
I
L
G
F
I
A
S
D
M
T
S
R
--
S
T
Q
L
W
----
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
Q
L
T
T
L
D
T
V
S
C
L
R
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
--
I
-
F
-
G
T
Q
-
G
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
-
V
M
-
H
S
Q
S
T
N
Q
L
D
V
---
P
R
-------
V
G
T
K
R
Y
M
A
P
E
V
L
D
E
T
I
Q
V
-
D
C
F
D
S
Y
K
R
V
D
I
W
A
F
G
L
V
L
W
E
V
A
R
R
M
V
S
NG
I
V
E
D
Y
K
P
P
F
Y
D
V
-----
V
P
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
N
I
P
N
R
W
----
F
S
D
P
T
L
T
S
L
A
K
---
L
---
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
L
R
I
K
K
T
L
T
K
I
D
----------------------------------------------------------------
52
PsiBlast_CBE
86.61
34%
-100
- C2 -
4DYM
5
ACVR1_HUMAN
A:
[9-300]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
I
T
L
L
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
S
W
Q
G
E
N
V
A
V
K
I
F
S
S
R
D
E
K
S
W
F
R
E
T
E
L
Y
N
T
V
M
L
R
H
E
N
I
L
G
F
I
A
S
D
M
T
S
R
H
S
S
T
Q
L
W
----
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
Q
L
T
T
L
D
T
V
S
C
L
R
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
--
I
-
F
-
G
T
Q
-
G
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
V
M
H
-
S
Q
S
T
N
Q
L
D
-
V
G
N
N
P
R
-------
V
G
T
K
R
Y
M
A
P
E
V
L
D
E
T
I
Q
V
-
D
C
F
D
S
Y
K
R
V
D
I
W
A
F
G
L
V
L
W
E
V
A
R
R
M
V
S
NG
I
V
E
D
Y
K
P
P
F
Y
D
V
-----
V
P
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
N
I
P
N
R
W
----
F
S
D
P
T
L
T
S
L
A
K
---
L
---
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
L
R
I
K
K
T
L
T
K
I
D
----------------------------------------------------------------
20
PsiBlast_PDB
86.50
34%
-99
- C2 -
3Q4U
7
ACVR1_HUMAN
A:
[9-300]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
I
T
L
L
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
S
W
Q
G
E
N
V
A
V
K
I
F
S
S
R
D
E
K
S
W
F
R
E
T
E
L
Y
N
T
V
M
L
R
H
E
N
I
L
G
F
I
A
S
D
M
T
S
R
H
S
S
T
Q
L
W
----
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
Q
L
T
T
L
D
T
V
S
C
L
R
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
--
I
-
F
-
G
T
Q
-
G
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
V
M
H
-
S
Q
S
T
N
Q
L
D
-
V
G
N
N
P
R
-------
V
G
T
K
R
Y
M
A
P
E
V
L
D
E
T
I
Q
V
-
D
C
F
D
S
Y
K
R
V
D
I
W
A
F
G
L
V
L
W
E
V
A
R
R
M
V
S
NG
I
V
E
D
Y
K
P
P
F
Y
D
V
-----
V
P
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
N
I
P
N
R
W
----
F
S
D
P
T
L
T
S
L
A
K
---
L
---
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
L
R
I
K
K
T
L
T
K
I
D
----------------------------------------------------------------
50
PsiBlast_CBE
86.42
34%
-102
- C2 -
3Q4U
3
ACVR1_HUMAN
B:
[9-300]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
I
T
L
L
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
S
W
Q
G
E
N
V
A
V
K
I
F
S
S
R
D
E
K
S
W
F
R
E
T
E
L
Y
N
T
V
M
L
R
H
E
N
I
L
G
F
I
A
S
D
M
T
S
R
H
S
S
T
Q
L
W
----
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
Q
L
T
T
L
D
T
V
S
C
L
R
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
--
I
-
F
-
G
T
Q
-
G
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
V
M
H
-
S
Q
S
T
N
Q
L
D
-
V
G
N
N
P
R
-------
V
G
T
K
R
Y
M
A
P
E
V
L
D
E
T
I
Q
V
-
D
C
F
D
S
Y
K
R
V
D
I
W
A
F
G
L
V
L
W
E
V
A
R
R
M
V
S
NG
I
V
E
D
Y
K
P
P
F
Y
D
V
-----
V
P
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
N
I
P
N
R
W
----
F
S
D
P
T
L
T
S
L
A
K
---
L
---
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
L
R
I
K
K
T
L
T
K
I
-----------------------------------------------------------------
4
PsiBlast_PDB
86.41
34%
-98
- C2 -
4ASX
5
AVR2A_HUMAN
A:
[10-316]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
G
V
D
L
G
T
E
N
L
Y
F
Q
S
M
P
-
L
Q
L
L
E
V
K
A
R
G
R
F
G
C
V
W
K
A
Q
L
L
N
E
Y
V
A
V
K
I
F
P
I
Q
D
K
Q
S
W
Q
N
E
Y
E
V
Y
S
L
P
G
M
K
H
E
N
I
L
Q
F
I
G
A
---
E
K
R
G
T
S
V
D
V
D
-
L
W
L
I
T
A
F
H
E
K
G
S
L
S
D
F
L
K
A
N
V
V
S
W
N
E
L
C
H
I
A
E
T
M
A
R
G
L
A
Y
L
H
E
D
IP
G
-
L
K
D
G
--
H
K
P
A
I
S
H
R
D
I
K
S
K
N
V
L
L
K
N
N
L
T
A
C
I
A
D
F
G
L
A
L
K
F
-
E
A
---
G
K
S
A
G
-
T
H
G
Q
-------
V
G
T
R
R
Y
M
A
P
E
V
L
E
G
A
I
N
F
Q
R
--
D
A
F
L
R
I
D
M
Y
A
M
G
L
V
L
W
E
L
A
S
R
C
T
----
A
A
D
G
P
V
D
E
Y
M
L
P
F
E
E
E
I
G
Q
H
P
S
L
E
D
M
Q
E
V
V
V
H
K
K
K
R
P
V
L
R
D
Y
W
Q
-
K
H
A
G
M
A
---
M
L
C
E
---
T
---
I
E
E
C
W
D
H
D
A
E
A
R
L
S
A
G
C
V
G
E
R
I
T
Q
M
Q
R
L
T
-------------------------------------------------------------
49
PsiBlast_CBE
86.38
34%
-98
- C2 -
3Q4U
6
ACVR1_HUMAN
C:
[9-300]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
I
T
L
L
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
S
W
Q
G
E
N
V
A
V
K
I
F
S
S
R
D
E
K
S
W
F
R
E
T
E
L
Y
N
T
V
M
L
R
H
E
N
I
L
G
F
I
A
S
D
M
T
S
R
H
S
S
T
Q
L
W
----
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
Q
L
T
T
L
D
T
V
S
C
L
R
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
--
I
-
F
-
G
T
Q
-
G
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
V
M
H
-
S
Q
S
T
N
Q
L
D
-
V
G
N
N
P
R
-------
V
G
T
K
R
Y
M
A
P
E
V
L
D
E
T
I
Q
V
-
D
C
F
D
S
Y
K
R
V
D
I
W
A
F
G
L
V
L
W
E
V
A
R
R
M
V
S
NG
I
V
E
D
Y
K
P
P
F
Y
D
V
-----
V
P
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
N
I
P
N
R
W
----
F
S
D
P
T
L
T
S
L
A
K
---
L
---
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
L
R
I
K
K
T
L
T
K
I
D
----------------------------------------------------------------
3
PsiBlast_PDB
86.24
34%
-97
- C2 -
3SOC
7
AVR2A_HUMAN
A:
[14-316]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
T
E
N
L
Y
F
Q
S
M
P
-
L
Q
L
L
E
V
K
A
R
G
R
F
G
C
V
W
K
A
Q
L
L
N
E
Y
V
A
V
K
I
F
P
I
Q
D
K
Q
S
W
Q
N
E
Y
E
V
Y
S
L
P
G
M
K
H
E
N
I
L
Q
F
I
G
A
---
E
K
R
G
T
S
V
D
V
D
-
L
W
L
I
T
A
F
H
E
K
G
S
L
S
D
F
L
K
A
N
V
V
S
W
N
E
L
C
H
I
A
E
T
M
A
R
G
L
A
Y
L
H
E
D
I
P
G
-
L
K
D
G
--
H
K
P
A
I
S
H
R
D
I
K
S
K
N
V
L
L
K
N
N
L
T
A
C
I
A
D
F
G
L
A
L
K
F
-
E
A
---
G
K
S
A
G
D
T
H
G
Q
-------
V
G
T
R
R
Y
M
A
P
E
V
L
E
G
A
I
N
F
Q
R
--
D
A
F
L
R
I
D
M
Y
A
M
G
L
V
L
W
E
L
A
S
R
C
T
----
A
A
D
G
P
V
D
E
Y
M
L
P
F
E
E
E
I
G
Q
H
P
S
L
E
D
M
Q
E
V
V
V
H
K
K
K
R
P
V
L
R
D
Y
W
Q
-
K
H
A
G
M
A
---
M
L
C
E
---
T
---
I
E
E
C
W
D
H
D
A
E
A
R
L
S
A
G
C
V
G
E
R
I
T
Q
M
Q
R
L
T
-------------------------------------------------------------
18
PsiBlast_PDB
85.55
34%
-100
- C2 -
3MTF
12
ACVR1_HUMAN
A:
[9-300]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
I
T
L
L
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
S
W
Q
G
E
N
V
A
V
K
I
F
S
S
R
D
E
K
S
W
F
R
E
T
E
L
Y
N
T
V
M
L
R
H
E
N
I
L
G
F
I
A
S
D
M
T
S
R
H
S
S
T
Q
L
W
----
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
Q
L
T
T
L
D
T
V
S
C
L
R
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
--
I
-
F
-
G
T
Q
-
G
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
V
M
H
-
S
Q
S
T
N
Q
L
D
-
V
G
N
N
P
R
-------
V
G
T
K
R
Y
M
A
P
E
V
L
D
E
T
I
Q
V
-
D
C
F
D
S
Y
K
R
V
D
I
W
A
F
G
L
V
L
W
E
V
A
R
R
M
V
S
NG
I
V
E
D
Y
K
P
P
F
Y
D
V
-----
V
P
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
N
I
P
N
R
W
----
F
S
D
P
T
L
T
S
L
A
K
---
L
---
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
L
R
I
K
K
T
L
T
K
I
-----------------------------------------------------------------
19
PsiBlast_PDB
84.84
34%
-99
- C2 -
3OOM
16
ACVR1_HUMAN
A:
[9-300]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
I
T
L
L
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
S
W
Q
G
E
N
V
A
V
K
I
F
S
S
R
D
E
K
S
W
F
R
E
T
E
L
Y
N
T
V
M
L
R
H
E
N
I
L
G
F
I
A
S
D
M
T
S
R
H
S
S
T
Q
L
W
----
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
Q
L
T
T
L
D
T
V
S
C
L
R
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
--
I
-
F
-
G
T
Q
-
G
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
V
M
H
-
S
Q
S
T
N
Q
L
D
-
V
G
N
N
P
R
-------
V
G
T
K
R
Y
M
A
P
E
V
L
D
E
T
I
Q
V
-
D
C
F
D
S
Y
K
R
V
D
I
W
A
F
G
L
V
L
W
E
V
A
R
R
M
V
S
NG
I
V
E
D
Y
K
P
P
F
Y
D
V
-----
V
P
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
N
I
P
N
R
W
----
F
S
D
P
T
L
T
S
L
A
K
---
L
---
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
L
R
I
K
K
T
L
T
K
I
D
----------------------------------------------------------------
53
PsiBlast_CBE
83.75
33%
-90
- C2 -
3MDY
1
BMR1B_HUMAN
C:
[45-334]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
K
G
R
Y
G
E
V
W
M
G
K
W
R
G
E
K
V
A
V
K
V
F
F
T
T
E
E
A
S
W
F
R
E
T
E
I
Y
Q
T
V
L
M
R
H
E
N
I
L
G
F
I
A
A
---
D
I
K
G
T
G
S
W
-
T
Q
L
Y
L
I
T
D
Y
H
E
N
G
S
L
Y
D
Y
L
K
S
T
T
L
D
A
K
S
M
L
K
L
A
Y
S
S
V
S
G
L
C
H
L
H
T
E
--
I
-
F
S
T
-
Q
-
G
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
T
C
C
I
A
D
L
G
L
A
V
K
F
-
I
-------
I
P
P
N
T
--------
R
V
G
T
K
R
Y
M
P
P
E
V
L
D
E
S
L
N
R
N
H
F
Q
S
Y
I
-
M
A
D
M
Y
S
F
G
L
I
L
W
E
V
A
R
R
C
V
-----
S
G
G
I
V
E
E
Y
Q
L
P
Y
H
D
L
V
P
S
D
P
S
Y
E
D
M
R
E
I
V
C
I
K
K
L
R
P
S
F
P
N
R
W
-----
S
S
D
--
E
C
L
R
Q
M
G
K
L
---
M
T
E
C
W
A
H
N
P
A
S
R
L
T
A
L
R
V
K
K
T
L
A
K
M
S
E
S
Q
D
I
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