@TOME V2.3
(Nov 2016)
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : ARAF_HUMAN: (2015-10-03 )
MEPPRGPPANGAEPSRAVGTVKVYLPNKQRTVVTVRDGMSVYDSLDKALKVRGLNQDCCVVYRLIKGRKTVTAWDTAIAPLDGEELIVEVLEDVPLTMHNFVRKTFFSLAFCDFCLKFLFHGFRCQTCGYKFHQHCSSKVPTVCVDMSTNRQQFYHSVQDLSGGSRQHEAPSNRPLNELLTPQGPSPRTQHCDPEHFPFPAPANAPLQRIRSTSTPNVHMVSTTAPMDSNLIQLTGQSFSTDAAGSRGGSDGTPRGSPSPASVSSGRKSPHSKSPAEQRERKSLADDKKKVKNLGYRDSGYYWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP
Atome Classification :
(84 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.--------.--.......340.......350.......360.-.......370-.-.-.-.--...380.......390.....-------..--------400.-....-....410.......420---..--.....430......---.440.......450.--......460--........470.......480---...----.....490.......500..-.....510....-...520.......530.......540.......550.......560......-.570.......580.......590.......600....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MEPPRGPPANGAEPSR
A
V
G
T
V
K
V
Y
LPNK
Q
R
T
V
V
T
VRD
G
M
S
V
Y
D
S
L
D
K
A
L
K
VRGL
N
Q
D
C
C
V
V
Y
R
L
IKGR
K
T
V
T
AWDTAIAPLD
G
E
E
L
I
V
E
V
L
E
DV
P
L
T
M
H
N
F
V
R
K
T
F
F
S
L
A
F
C
D
F
C
L
K
F
L
FHG
F
R
CQTCG
Y
K
F
H
Q
H
CSSKV
P
T
V
C
V
DMST
N
R
Q
Q
F
Y
H
S
V
Q
DLSGGSRQHEAPSNRP
L
N
E
LLTPQGPSPRTQHCDPEHFPFPAPAN
A
P
L
Q
R
I
RSTSTP
N
V
H
M
V
S
TTAPMDS
N
L
I
Q
LTGQSFSTDAAGSRGGSDGTPRGSPSPASVSSGRKSPHSKS
P
A
E
Q
R
E
R
K
S
LAD
D
K
K
K
V
K
NLGYRDS
G
Y
Y
W
EV
P
P
S
E
V
Q
L
L
K
R
IGTGSFG
T
V
F
RGRWH--G--------
D
--
V
A
V
K
V
L
KVSQP
T
A
E
Q
A
Q
A
F
K
N
E
M
Q
V
L
R
KT-R-H
V
N
I
L
L
F
MGF-M-T-R-P--
G
F
A
I
I
T
Q
WCEGS
S
L
Y
H
H
L
H
VA-------D
T
--------
R
--
F
-
D
M
V
Q
-
L
I
D
V
A
R
Q
T
AQG
M
D
Y
L
H
A
---
K
N
--
I
I
H
R
DLKSN
N
I
F
L
H---E
G
L
T
V
K
IGDF
G
L
A
T
V
--
K
TRWSGA-Q--PLEQPSG
S
V
L
W
M
A
A
E
V
I
RMQ----DPN----PYS
F
Q
S
D
V
Y
A
Y
G
V
V
L
Y
E
L
M
T-GSLPYSHIGCR
D
-
Q
I
I
F
M
VGRGYLSP
D
L
S
K
I
SSN
C
P
K
A
M
R
R
L
L
S
D
C
L
K
F
Q
REERP
L
F
P
Q
I
L
A
T
I
E
-
L
L
Q
R
S
L
P
K
I
E
RSASEPSLHR
T
Q
A
D
E
L
P
A
C
L
L
S
A
ARLVP
51
PsiBlast_CBE
93.65
75%
-130
- C1 -
5CT7
1
?
B:
[7-279]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
--
G
--------
D
--
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
-
R
-
H
V
N
I
L
L
F
M
G
Y
-
S
-
T
-
K
-
P
--
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
I
-------
E
T
--------
K
--
F
-
E
M
I
K
-
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
---
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
---
E
D
L
T
V
K
I
G
D
F
------------------------
G
S
I
L
W
M
A
P
E
V
I
R
M
Q
----
D
K
N
----
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
-
Q
I
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
-
L
L
A
R
S
L
--------------------------------
50
PsiBlast_CBE
93.56
75%
-129
- C1 -
4KSP
1
BRAF_HUMAN
A:
[6-280]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
--
G
--------
D
--
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
-
R
-
H
V
N
I
L
L
F
M
G
Y
-
S
-
T
-
K
-
P
--
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
I
-------
E
T
--------
K
--
F
-
E
M
I
K
-
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
---
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
---
E
D
L
T
V
K
I
G
D
F
G
-----------------------
G
S
I
L
W
M
A
P
E
V
I
R
M
Q
----
D
K
N
----
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
-
Q
I
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
-
L
L
A
R
S
L
P
-------------------------------
52
PsiBlast_CBE
93.17
75%
-131
- C1 -
5CT7
1
?
A:
[7-279]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
--
G
--------
D
--
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
-
R
-
H
V
N
I
L
L
F
M
G
Y
-
S
-
T
-
K
-
P
--
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
I
-------
E
T
--------
K
--
F
-
E
M
I
K
-
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
---
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
---
E
D
L
T
V
K
I
G
D
F
G
L
A
---------------------
G
S
I
L
W
M
A
P
E
V
I
R
M
Q
----
D
K
N
----
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
-
Q
I
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
-
L
L
A
R
S
L
--------------------------------
55
PsiBlast_CBE
92.22
76%
-131
- C1 -
4H58
1
BRAF_HUMAN
A:
[3-275]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
--
G
--------
D
--
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
-
R
-
H
V
N
I
L
L
F
M
G
Y
-
S
-
T
-
K
-
P
--
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
I
-------
E
T
--------
K
--
F
-
E
M
I
K
-
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
---
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
---
E
D
L
T
V
K
I
G
D
F
G
L
A
T
V
--
K
S
---------------
G
S
I
L
W
M
A
P
E
V
I
R
M
Q
----
D
K
N
----
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
-
Q
I
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
-
L
L
A
R
S
L
P
-------------------------------
2
PsiBlast_PDB
91.87
76%
-129
- C1 -
3OMV
1
RAF1_HUMAN
A:
[29-304]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
Y
W
E
I
E
A
S
E
V
M
L
S
T
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
--
G
--------
D
--
V
A
V
K
I
L
K
V
V
D
P
T
P
E
Q
F
Q
A
F
R
N
E
V
A
V
L
R
K
T
-
R
-
H
V
N
I
L
L
F
M
G
Y
-
M
-
T
-
K
-
D
--
N
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
K
H
L
H
V
Q
-------
E
T
--------
K
--
F
-
Q
M
F
Q
-
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
---
K
N
--
I
I
H
R
D
M
K
S
N
N
I
F
L
H
---
E
G
L
T
V
K
I
G
D
F
G
L
A
T
V
-----------------
P
T
G
S
V
L
W
M
A
P
E
V
I
R
M
Q
----
D
N
N
----
P
F
S
F
Q
S
D
V
Y
S
Y
G
I
V
L
Y
E
L
M
T
-
G
E
L
P
Y
S
H
I
N
N
R
D
-
Q
I
I
F
M
V
G
R
G
Y
A
S
P
D
L
S
K
L
Y
K
N
C
P
K
A
M
K
R
L
V
A
D
C
V
K
K
V
K
E
E
R
P
L
F
P
Q
I
L
S
S
I
E
-
L
L
Q
H
S
L
P
K
------------------------------
22
PsiBlast_CBE
91.77
76%
-133
- C1 -
3OMV
1
B:
[29-304]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
Y
W
E
I
E
A
S
E
V
M
L
S
T
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
--
G
--------
D
--
V
A
V
K
I
L
K
V
V
D
P
T
P
E
Q
F
Q
A
F
R
N
E
V
A
V
L
R
K
T
-
R
-
H
V
N
I
L
L
F
M
G
Y
-
M
-
T
-
K
-
D
--
N
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
K
H
L
H
V
Q
-------
E
T
--------
K
--
F
-
Q
M
F
Q
-
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
---
K
N
--
I
I
H
R
D
M
K
S
N
N
I
F
L
H
---
E
G
L
T
V
K
I
G
D
F
G
L
A
T
V
-----------------
P
T
G
S
V
L
W
M
A
P
E
V
I
R
M
Q
----
D
N
N
----
P
F
S
F
Q
S
D
V
Y
S
Y
G
I
V
L
Y
E
L
M
T
-
G
E
L
P
Y
S
H
I
N
N
R
D
-
Q
I
I
F
M
V
G
R
G
Y
A
S
P
D
L
S
K
L
Y
K
N
C
P
K
A
M
K
R
L
V
A
D
C
V
K
K
V
K
E
E
R
P
L
F
P
Q
I
L
S
S
I
E
-
L
L
Q
H
S
L
P
K
------------------------------
41
PsiBlast_CBE
91.49
74%
-125
- C1 -
3IDP
1
B:
[22-293]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
--
G
--------
D
--
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
-
R
-
H
V
N
I
L
L
F
M
G
Y
-
S
-
T
-
K
-
P
--
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
I
-------
E
T
--------
K
--
F
-
E
M
I
K
-
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
---
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
---
E
D
L
T
V
K
I
G
D
F
G
---------------------
L
S
G
S
I
L
W
M
A
P
E
V
I
R
M
Q
----
D
K
N
----
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
-
Q
I
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
-
L
L
A
R
S
---------------------------------
67
PsiBlast_CBE
91.48
72%
-127
- C1 -
4CQE
1
?
A:
[5-275]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
--
G
T
V
Y
K
G
K
W
H
--
G
--------
D
--
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
-
R
-
H
V
N
I
L
L
F
M
G
Y
-
S
-
T
-
K
-
P
--
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
A
S
-------
E
T
--------
K
--
F
-
E
M
K
K
-
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
A
---
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
---
E
D
N
T
V
K
I
G
D
F
G
-----------------------
G
S
I
L
W
M
A
P
E
V
I
R
M
Q
------
N
----
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
-
Q
I
I
E
M
V
G
R
G
S
L
S
P
D
L
S
K
V
R
S
N
C
P
K
R
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
S
F
P
R
I
L
A
E
I
E
-
E
L
A
R
E
---------------------------------
49
PsiBlast_CBE
91.31
74%
-132
- C1 -
4MBJ
1
BRAF_HUMAN
A:
[29-304]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
--
G
--------
D
--
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
-
R
-
H
V
N
I
L
L
F
M
G
Y
-
S
-
T
-
K
-
P
--
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
I
-------
E
T
--------
K
--
F
-
E
M
I
K
-
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
---
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
---
E
D
L
T
V
K
I
G
D
F
G
L
A
T
V
--
K
S
R
W
S
----------
L
S
G
S
I
L
W
M
A
P
E
V
I
R
M
Q
----
D
K
N
----
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
-
Q
I
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
-
L
L
A
R
S
L
P
K
------------------------------
9
PsiBlast_PDB
90.97
74%
-129
- C1 -
3Q4C
1
BRAF_HUMAN
A:
[29-304]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
--
G
--------
D
--
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
-
R
-
H
V
N
I
L
L
F
M
G
Y
-
S
-
T
-
K
-
P
--
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
I
-------
E
T
--------
K
--
F
-
E
M
I
K
-
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
---
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
---
E
D
L
T
V
K
I
G
D
F
G
L
A
T
V
--
K
S
---------------
G
S
I
L
W
M
A
P
E
V
I
R
M
Q
----
D
K
N
----
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
-
Q
I
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
-
L
L
A
R
S
L
P
K
------------------------------
14
PsiBlast_PDB
90.96
74%
-123
- C1 -
4E26
1
BRAF_HUMAN
A:
[29-304]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
--
G
--------
D
--
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
-
R
-
H
V
N
I
L
L
F
M
G
Y
-
S
-
T
-
K
-
P
--
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
I
-------
E
T
--------
K
--
F
-
E
M
I
K
-
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
---
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
---
E
D
L
T
V
K
I
G
D
F
G
L
A
T
V
--
K
S
R
---------
F
E
Q
L
S
G
S
I
L
W
M
A
P
E
V
I
R
M
Q
----
D
K
N
----
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
-
Q
I
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
-
L
L
A
R
S
L
P
K
------------------------------
42
PsiBlast_CBE
90.93
74%
-127
- C1 -
3IDP
1
BRAF_HUMAN
A:
[22-293]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
--
G
--------
D
--
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
-
R
-
H
V
N
I
L
L
F
M
G
Y
-
S
-
T
-
K
-
P
--
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
I
-------
E
T
--------
K
--
F
-
E
M
I
K
-
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
---
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
---
E
D
L
T
V
K
I
G
D
F
G
L
A
T
--------------------
G
S
I
L
W
M
A
P
E
V
I
R
M
Q
------
N
----
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
-
Q
I
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
-
L
L
A
R
S
---------------------------------
66
PsiBlast_CBE
90.83
72%
-125
- C1 -
4CQE
1
?
B:
[5-275]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
---
T
V
Y
K
G
K
W
H
--
G
--------
D
--
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
-
R
-
H
V
N
I
L
L
F
M
G
Y
-
S
-
T
-
K
-
P
--
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
A
S
-------
E
T
--------
K
--
F
-
E
M
K
K
-
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
A
---
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
---
E
D
N
T
V
K
I
G
D
F
G
-----------------------
G
S
I
L
W
M
A
P
E
V
I
R
--------
N
----
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
-
Q
I
I
E
M
V
G
R
G
S
L
S
P
D
L
S
K
V
R
S
N
C
P
K
R
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
S
F
P
R
I
L
A
E
I
E
-
E
L
A
R
E
---------------------------------
112
HHSearch
90.73
74%
-128
- C1 -
4MNF
1
BRAF_HUMAN
A:
[42-313]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
--
G
--------
D
--
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
-
R
-
H
V
N
I
L
L
F
M
G
Y
-
S
-
T
-
K
-
P
--
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
I
-------
E
T
--------
K
--
F
-
E
M
I
K
-
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
---
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
---
E
D
L
T
V
K
I
G
D
F
G
L
A
T
E
--------------------
S
I
L
W
M
A
P
E
V
I
R
M
Q
----
D
K
N
----
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
-
Q
I
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
-
L
L
A
R
S
---------------------------------
12
PsiBlast_PDB
90.44
74%
-129
- C1 -
3TV4
1
BRAF_HUMAN
A:
[29-304]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
--
S
F
G
T
V
Y
K
G
K
W
H
--
G
--------
D
--
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
-
R
-
H
V
N
I
L
L
F
M
G
Y
-
S
-
T
-
K
-
P
--
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
I
-------
E
T
--------
K
--
F
-
E
M
I
K
-
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
---
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
---
E
D
L
T
V
K
I
G
D
F
G
L
A
T
V
--
K
S
R
-------------
S
G
S
I
L
W
M
A
P
E
V
I
R
M
Q
----
D
K
N
----
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
-
Q
I
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
-
L
L
A
R
S
L
P
K
------------------------------
1
PsiBlast_PDB
90.41
73%
-128
- C1 -
4MNF
1
BRAF_HUMAN
A:
[42-313]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
--
G
--------
D
--
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
-
R
-
H
V
N
I
L
L
F
M
G
Y
-
S
-
T
-
K
-
P
--
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
I
-------
E
T
--------
K
--
F
-
E
M
I
K
-
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
---
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
---
E
D
L
T
V
K
I
G
D
F
G
L
A
T
E
--------------------
S
I
L
W
M
A
P
E
V
I
R
M
Q
----
D
K
N
----
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
-
Q
I
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
-
L
L
A
R
S
---------------------------------
16
PsiBlast_PDB
90.40
74%
-125
- C1 -
4G9C
1
BRAF_HUMAN
A:
[29-304]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
--
G
--------
D
--
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
-
R
-
H
V
N
I
L
L
F
M
G
Y
-
S
-
T
-
K
-
P
--
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
I
-------
E
T
--------
K
--
F
-
E
M
I
K
-
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
---
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
---
E
D
L
T
V
K
I
G
D
F
G
L
A
T
V
--
K
--------------
L
S
G
S
I
L
W
M
A
P
E
V
I
R
M
Q
----
D
K
N
----
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
-
Q
I
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
-
L
L
A
R
S
L
P
K
------------------------------
21
PsiBlast_CBE
90.36
73%
-128
- C1 -
4MNF
1
B:
[42-313]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
--
G
--------
D
--
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
-
R
-
H
V
N
I
L
L
F
M
G
Y
-
S
-
T
-
K
-
P
--
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
I
-------
E
T
--------
K
--
F
-
E
M
I
K
-
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
---
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
---
E
D
L
T
V
K
I
G
D
F
G
L
A
T
E
--------------------
S
I
L
W
M
A
P
E
V
I
R
M
Q
----
D
K
N
----
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
-
Q
I
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
-
L
L
A
R
S
---------------------------------
13
PsiBlast_PDB
90.18
74%
-128
- C1 -
3TV6
1
BRAF_HUMAN
A:
[29-304]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
--
G
--------
D
--
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
-
R
-
H
V
N
I
L
L
F
M
G
Y
-
S
-
T
-
K
-
P
--
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
I
-------
E
T
--------
K
--
F
-
E
M
I
K
-
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
---
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
---
E
D
L
T
V
K
I
G
D
F
G
L
A
T
V
--
K
S
R
W
S
-----------
S
G
S
I
L
W
M
A
P
E
V
I
R
M
Q
----
D
K
N
----
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
-
Q
I
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
-
L
L
A
R
S
L
P
K
------------------------------
11
PsiBlast_PDB
90.17
74%
-128
- C1 -
3SKC
1
BRAF_HUMAN
A:
[29-304]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
--
G
--------
D
--
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
-
R
-
H
V
N
I
L
L
F
M
G
Y
-
S
-
T
-
K
-
P
--
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
I
-------
E
T
--------
K
--
F
-
E
M
I
K
-
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
---
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
---
E
D
L
T
V
K
I
G
D
F
G
---------------------
L
S
G
S
I
L
W
M
A
P
E
V
I
R
M
Q
----
D
K
N
----
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
-
Q
I
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
-
L
L
A
R
S
L
P
K
------------------------------
64
PsiBlast_CBE
90.01
72%
-126
- C1 -
4WO5
1
B:
[27-298]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
--
G
--------
D
--
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
-
R
-
H
V
N
I
L
L
F
M
G
Y
-
S
-
T
-
K
-
P
--
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
A
S
-------
E
T
--------
K
--
F
-
E
M
K
K
-
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
A
---
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
---
E
D
N
T
V
K
I
G
D
F
G
L
A
T
--------------------
G
S
I
L
W
M
A
P
E
V
I
R
M
Q
----
D
S
N
----
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
-
Q
I
I
E
M
V
G
R
G
S
L
S
P
D
L
S
K
V
R
S
N
C
P
K
R
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
S
F
P
R
I
L
A
E
I
E
-
E
L
A
R
E
L
--------------------------------
15
PsiBlast_PDB
89.99
74%
-131
- C1 -
4E4X
1
BRAF_HUMAN
A:
[29-302]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
--
G
--------
D
--
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
-
R
-
H
V
N
I
L
L
F
M
G
Y
-
S
-
T
-
K
-
P
--
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
I
-------
E
T
--------
K
--
F
-
E
M
I
K
-
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
---
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
---
E
D
L
T
V
K
I
G
D
F
G
L
A
T
V
--
K
S
R
W
S
----------
L
S
G
S
I
L
W
M
A
P
E
V
I
R
M
Q
----
D
K
N
----
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
-
Q
I
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
-
L
L
A
R
S
L
--------------------------------
37
PsiBlast_CBE
89.84
74%
-125
- C1 -
3D4Q
1
B:
[29-304]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
--
G
--------
D
--
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
-
R
-
H
V
N
I
L
L
F
M
G
Y
-
S
-
T
-
K
-
P
--
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
I
-------
E
T
--------
K
--
F
-
E
M
I
K
-
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
---
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
---
E
D
L
T
V
K
I
G
D
F
G
L
A
T
V
-----------------
L
S
G
S
I
L
W
M
A
P
E
V
I
R
M
Q
----
D
K
N
----
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
-
Q
I
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
-
L
L
A
R
S
L
P
K
------------------------------
46
PsiBlast_CBE
89.71
73%
-129
- C1 -
4EHG
1
B:
[29-304]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
--
G
--------
D
--
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
-
R
-
H
V
N
I
L
L
F
M
G
Y
-
S
-
T
-
K
-
P
--
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
I
-------
E
T
--------
K
--
F
-
E
M
I
K
-
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
---
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
---
E
D
L
T
V
K
I
G
D
F
G
---------------------
L
S
G
S
I
L
W
M
A
P
E
V
I
R
M
Q
----
D
K
N
----
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
-
Q
I
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
-
L
L
A
R
S
L
P
K
------------------------------
43
PsiBlast_CBE
89.64
73%
-128
- C1 -
5C9C
1
?
A:
[30-301]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
--
G
--------
D
--
V
A
V
K
M
L
N
--
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
-
R
-
H
V
N
I
L
L
F
M
G
Y
-
S
-
T
-
K
-
P
--
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
I
-------
E
T
--------
K
--
F
-
E
M
I
K
-
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
---
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
---
E
D
L
T
V
K
I
G
D
F
G
L
A
T
---------------------
S
I
L
W
M
A
P
E
V
I
R
M
Q
----
D
K
N
----
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
-
Q
I
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
-
L
L
A
R
S
---------------------------------
7
PsiBlast_PDB
89.55
74%
-129
- C1 -
3PRF
1
BRAF_HUMAN
A:
[29-304]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
--
G
--------
D
--
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
-
R
-
H
V
N
I
L
L
F
M
G
Y
-
S
-
T
-
K
-
P
--
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
I
-------
E
T
--------
K
--
F
-
E
M
I
K
-
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
---
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
---
E
D
L
T
V
K
I
G
D
F
G
L
A
T
V
-------------------
G
S
I
L
W
M
A
P
E
V
I
R
M
Q
----
D
K
N
----
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
-
Q
I
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
-
L
L
A
R
S
L
P
K
------------------------------
6
PsiBlast_PDB
89.51
74%
-130
- C1 -
3PPK
1
BRAF_HUMAN
A:
[29-304]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
--
G
--------
D
--
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
-
R
-
H
V
N
I
L
L
F
M
G
Y
-
S
-
T
-
K
-
P
--
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
I
-------
E
T
--------
K
--
F
-
E
M
I
K
-
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
---
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
---
E
D
L
T
V
K
I
G
D
F
G
L
A
T
V
-------------------
G
S
I
L
W
M
A
P
E
V
I
R
M
Q
----
D
K
N
----
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
-
Q
I
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
-
L
L
A
R
S
L
P
K
------------------------------
38
PsiBlast_CBE
89.45
74%
-131
- C1 -
3II5
1
B:
[29-301]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
--
G
--------
D
--
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
-
R
-
H
V
N
I
L
L
F
M
G
Y
-
S
-
T
-
K
-
P
--
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
I
-------
E
T
--------
K
--
F
-
E
M
I
K
-
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
---
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
---
E
D
L
T
V
K
I
G
D
F
G
L
A
---------------------
G
S
I
L
W
M
A
P
E
V
I
R
M
Q
----
D
K
N
----
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
-
Q
I
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
-
L
L
A
R
S
L
--------------------------------
24
PsiBlast_CBE
89.45
74%
-127
- C1 -
4G9C
1
B:
[29-304]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
--
G
--------
D
--
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
-
R
-
H
V
N
I
L
L
F
M
G
Y
-
S
-
T
-
K
-
P
--
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
I
-------
E
T
--------
K
--
F
-
E
M
I
K
-
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
---
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
---
E
D
L
T
V
K
I
G
D
F
G
L
A
T
V
-----------------
L
S
G
S
I
L
W
M
A
P
E
V
I
R
M
Q
----
D
K
N
----
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
-
Q
I
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
-
L
L
A
R
S
L
P
K
------------------------------
27
PsiBlast_CBE
89.44
74%
-125
- C1 -
4E26
1
B:
[29-303]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
--
G
--------
D
--
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
-
R
-
H
V
N
I
L
L
F
M
G
Y
-
S
-
T
-
K
-
P
--
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
I
-------
E
T
--------
K
--
F
-
E
M
I
K
-
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
---
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
---
E
D
L
T
V
K
I
G
D
F
G
L
A
T
V
--
K
S
--------------
S
G
S
I
L
W
M
A
P
E
V
I
R
M
Q
----
D
K
N
----
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
-
Q
I
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
-
L
L
A
R
S
L
P
-------------------------------
19
PsiBlast_PDB
89.41
74%
-124
- C1 -
3II5
1
BRAF_HUMAN
A:
[28-300]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
--
G
--------
D
--
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
-
R
-
H
V
N
I
L
L
F
M
G
Y
-
S
-
T
-
K
-
P
--
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
I
-------
E
T
--------
K
--
F
-
E
M
I
K
-
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
---
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
---
E
D
L
T
V
K
I
G
D
F
G
L
A
T
V
----------------
Q
L
S
G
S
I
L
W
M
A
P
E
V
I
R
M
Q
----
D
K
N
----
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
-
Q
I
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
-
L
L
A
R
S
---------------------------------
10
PsiBlast_PDB
89.35
74%
-128
- C1 -
3PSD
1
BRAF_HUMAN
A:
[29-304]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
--
G
--------
D
--
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
-
R
-
H
V
N
I
L
L
F
M
G
Y
-
S
-
T
-
K
-
P
--
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
I
-------
E
T
--------
K
--
F
-
E
M
I
K
-
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
---
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
---
E
D
L
T
V
K
I
G
D
F
G
L
A
T
V
-------------------
G
S
I
L
W
M
A
P
E
V
I
R
M
Q
----
D
K
N
----
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
-
Q
I
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
-
L
L
A
R
S
L
P
K
------------------------------
18
PsiBlast_PDB
89.28
74%
-127
- C1 -
4PP7
1
BRAF_HUMAN
A:
[29-302]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
--
G
--------
D
--
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
-
R
-
H
V
N
I
L
L
F
M
G
Y
-
S
-
T
-
K
-
P
--
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
I
-------
E
T
--------
K
--
F
-
E
M
I
K
-
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
---
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
---
E
D
L
T
V
K
I
G
D
F
G
L
A
T
V
--
K
S
R
W
S
----------
L
S
G
S
I
L
W
M
A
P
E
V
I
R
M
Q
----
D
K
N
----
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
-
Q
I
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
-
L
L
A
R
S
L
--------------------------------
113
HHSearch
89.07
72%
-131
- C1 -
3OG7
1
BRAF_HUMAN
A:
[18-287]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
--
G
--------
D
--
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
-
R
-
H
V
N
I
L
L
F
M
G
Y
-
S
-
T
-
A
-
P
--
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
A
S
--------------------
F
-
E
M
K
K
-
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
A
---
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
---
E
D
N
T
V
K
I
G
D
F
G
-----------------------
G
S
I
L
W
M
A
P
E
V
I
R
--------
N
----
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
-
Q
I
I
E
M
V
G
R
G
S
L
S
P
D
L
S
K
V
R
S
N
C
P
K
R
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
S
F
P
R
I
L
A
E
I
E
-
E
L
A
R
E
---------------------------------
4
PsiBlast_PDB
89.06
74%
-126
- C1 -
3PSB
1
BRAF_HUMAN
A:
[29-304]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
--
G
--------
D
--
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
-
R
-
H
V
N
I
L
L
F
M
G
Y
-
S
-
T
-
K
-
P
--
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
I
-------
E
T
--------
K
--
F
-
E
M
I
K
-
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
---
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
---
E
D
L
T
V
K
I
G
D
F
G
L
A
T
V
-------------------
G
S
I
L
W
M
A
P
E
V
I
R
M
Q
----
D
K
N
----
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
-
Q
I
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
-
L
L
A
R
S
L
P
K
------------------------------
25
PsiBlast_CBE
88.98
74%
-121
- C1 -
4EHE
1
B:
[29-304]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
--
G
--------
D
--
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
-
R
-
H
V
N
I
L
L
F
M
G
Y
-
S
-
T
-
K
-
P
--
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
I
-------
E
T
--------
K
--
F
-
E
M
I
K
-
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
---
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
---
E
D
L
T
V
K
I
G
D
F
G
L
A
T
V
--
K
S
R
W
S
G
S
-
H
--
Q
F
E
Q
L
S
G
S
I
L
W
M
A
P
E
V
I
R
M
Q
----
D
K
N
----
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
-
Q
I
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
-
L
L
A
R
S
L
P
K
------------------------------
54
PsiBlast_CBE
88.95
76%
-128
- C1 -
1UWH
1
BRAF_HUMAN
A:
[3-276]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
--
G
--------
D
--
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
-
R
-
H
V
N
I
L
L
F
M
G
Y
-
S
-
T
-
A
-
P
--
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
I
-------
E
T
--------
K
--
F
-
E
M
I
K
-
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
---
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
---
E
D
L
T
V
K
I
G
D
F
G
L
A
T
V
-----------------
L
S
G
S
I
L
W
M
A
P
E
V
I
R
M
Q
----
D
K
N
----
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
-
Q
I
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
-
L
L
A
R
S
L
P
K
------------------------------
17
PsiBlast_PDB
88.80
74%
-127
- C1 -
4EHE
1
BRAF_HUMAN
A:
[29-304]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
--
G
--------
D
--
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
-
R
-
H
V
N
I
L
L
F
M
G
Y
-
S
-
T
-
K
-
P
--
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
I
-------
E
T
--------
K
--
F
-
E
M
I
K
-
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
---
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
---
E
D
L
T
V
K
I
G
D
F
G
L
A
T
V
--
K
S
R
-------------
S
G
S
I
L
W
M
A
P
E
V
I
R
M
Q
----
D
K
N
----
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
-
Q
I
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
-
L
L
A
R
S
L
P
K
------------------------------
65
PsiBlast_CBE
88.73
71%
-131
- C1 -
3OG7
1
BRAF_HUMAN
A:
[18-288]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
--
G
--------
D
--
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
-
R
-
H
V
N
I
L
L
F
M
G
Y
-
S
-
T
-
A
-
P
--
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
A
S
--------------------
F
-
E
M
K
K
-
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
A
---
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
---
E
D
N
T
V
K
I
G
D
F
G
-----------------------
G
S
I
L
W
M
A
P
E
V
I
R
--------
N
----
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
-
Q
I
I
E
M
V
G
R
G
S
L
S
P
D
L
S
K
V
R
S
N
C
P
K
R
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
S
F
P
R
I
L
A
E
I
E
-
E
L
A
R
E
---------------------------------
3
PsiBlast_PDB
88.66
74%
-124
- C1 -
3D4Q
1
BRAF_HUMAN
A:
[29-304]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
--
G
--------
D
--
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
-
R
-
H
V
N
I
L
L
F
M
G
Y
-
S
-
T
-
K
-
P
--
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
I
-------
E
T
--------
K
--
F
-
E
M
I
K
-
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
---
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
---
E
D
L
T
V
K
I
G
D
F
G
L
A
T
V
-----------------
L
S
G
S
I
L
W
M
A
P
E
V
I
R
M
Q
----
D
K
N
----
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
-
Q
I
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
-
L
L
A
R
S
L
P
K
------------------------------
60
PsiBlast_CBE
88.38
72%
-127
- C1 -
4JVG
1
BRAF_HUMAN
B:
[9-282]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
--
G
--------
D
--
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
-
R
-
H
V
N
I
L
L
F
M
G
Y
-
S
-
T
-
K
-
P
--
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
A
S
-------
E
T
--------
K
--
F
-
E
M
K
K
-
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
A
---
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
---
E
D
N
T
V
K
I
G
D
F
G
L
A
T
---------------------
S
I
L
W
M
A
P
E
V
I
R
M
Q
----
D
S
N
----
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
-
Q
I
I
E
M
V
G
R
G
S
L
S
P
D
L
S
K
V
R
S
N
C
P
K
R
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
S
F
P
R
I
L
A
E
I
E
-
E
L
A
R
E
L
S
-------------------------------
34
PsiBlast_CBE
88.26
74%
-126
- C1 -
3PRF
1
B:
[29-304]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
--
G
--------
D
--
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
-
R
-
H
V
N
I
L
L
F
M
G
Y
-
S
-
T
-
K
-
P
--
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
I
-------
E
T
--------
K
--
F
-
E
M
I
K
-
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
---
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
---
E
D
L
T
V
K
I
G
D
F
G
L
A
T
V
-------------------
G
S
I
L
W
M
A
P
E
V
I
R
M
Q
----
D
K
N
----
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
-
Q
I
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
-
L
L
A
R
S
L
P
K
------------------------------
35
PsiBlast_CBE
88.15
74%
-127
- C1 -
3PPK
1
B:
[29-304]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
--
G
--------
D
--
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
-
R
-
H
V
N
I
L
L
F
M
G
Y
-
S
-
T
-
K
-
P
--
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
I
-------
E
T
--------
K
--
F
-
E
M
I
K
-
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
---
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
---
E
D
L
T
V
K
I
G
D
F
G
L
A
T
V
-----------------
L
S
G
S
I
L
W
M
A
P
E
V
I
R
M
Q
----
D
K
N
----
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
-
Q
I
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
-
L
L
A
R
S
L
P
K
------------------------------
31
PsiBlast_CBE
88.01
74%
-124
- C1 -
3PSD
1
B:
[29-304]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
--
G
--------
D
--
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
-
R
-
H
V
N
I
L
L
F
M
G
Y
-
S
-
T
-
K
-
P
--
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
I
-------
E
T
--------
K
--
F
-
E
M
I
K
-
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
---
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
---
E
D
L
T
V
K
I
G
D
F
G
L
A
T
V
-----------------
L
S
G
S
I
L
W
M
A
P
E
V
I
R
M
Q
----
D
K
N
----
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
-
Q
I
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
-
L
L
A
R
S
L
P
K
------------------------------
62
PsiBlast_CBE
87.93
72%
-127
- C1 -
3C4C
1
B:
[5-278]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
--
G
--------
D
--
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
-
R
-
H
V
N
I
L
L
F
M
G
Y
-
S
-
T
-
K
-
P
--
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
A
S
-------
E
T
--------
K
--
F
-
E
M
K
K
-
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
A
---
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
---
E
D
N
T
V
K
I
G
D
F
-----------------------
S
G
S
I
L
W
M
A
P
E
V
I
R
M
Q
----
D
S
N
----
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
-
Q
I
I
E
M
V
G
R
G
S
L
S
P
D
L
S
K
V
R
S
N
C
P
K
R
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
S
F
P
R
I
L
A
E
I
E
-
E
L
A
R
E
L
S
-------------------------------
29
PsiBlast_CBE
87.78
74%
-123
- C1 -
3TV4
1
B:
[29-304]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
--
G
--------
D
--
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
-
R
-
H
V
N
I
L
L
F
M
G
Y
-
S
-
T
-
K
-
P
--
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
I
-------
E
T
--------
K
--
F
-
E
M
I
K
-
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
---
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
---
E
D
L
T
V
K
I
G
D
F
G
L
A
T
V
--
K
S
R
W
S
G
S
-
H
--
Q
F
E
Q
L
S
G
S
I
L
W
M
A
P
E
V
I
R
M
Q
----
D
K
N
----
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
-
Q
I
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
-
L
L
A
R
S
L
P
K
------------------------------
28
PsiBlast_CBE
87.75
74%
-124
- C1 -
3TV6
1
B:
[29-304]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
--
G
--------
D
--
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
-
R
-
H
V
N
I
L
L
F
M
G
Y
-
S
-
T
-
K
-
P
--
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
I
-------
E
T
--------
K
--
F
-
E
M
I
K
-
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
---
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
---
E
D
L
T
V
K
I
G
D
F
G
L
A
T
V
--
K
S
R
W
S
G
S
-
H
--
Q
F
E
Q
L
S
G
S
I
L
W
M
A
P
E
V
I
R
M
Q
----
D
K
N
----
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
-
Q
I
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
-
L
L
A
R
S
L
P
K
------------------------------
36
PsiBlast_CBE
87.36
74%
-125
- C1 -
3PPJ
1
B:
[29-304]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
--
G
--------
D
--
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
-
R
-
H
V
N
I
L
L
F
M
G
Y
-
S
-
T
-
K
-
P
--
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
I
-------
E
T
--------
K
--
F
-
E
M
I
K
-
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
---
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
---
E
D
L
T
V
K
I
G
D
F
G
L
A
T
V
-----------------
L
S
G
S
I
L
W
M
A
P
E
V
I
R
M
Q
----
D
K
N
----
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
-
Q
I
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
-
L
L
A
R
S
L
P
K
------------------------------
32
PsiBlast_CBE
87.31
74%
-125
- C1 -
3PSB
1
B:
[29-304]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
--
G
--------
D
--
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
-
R
-
H
V
N
I
L
L
F
M
G
Y
-
S
-
T
-
K
-
P
--
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
I
-------
E
T
--------
K
--
F
-
E
M
I
K
-
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
---
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
---
E
D
L
T
V
K
I
G
D
F
G
L
A
T
V
-----------------
L
S
G
S
I
L
W
M
A
P
E
V
I
R
M
Q
----
D
K
N
----
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
-
Q
I
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
-
L
L
A
R
S
L
P
K
------------------------------
53
PsiBlast_CBE
87.12
76%
-127
- C1 -
1UWH
1
B:
[3-276]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
--
G
--------
D
--
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
-
R
-
H
V
N
I
L
L
F
M
G
Y
-
S
-
T
-
A
-
P
--
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
I
-------
E
T
--------
K
--
F
-
E
M
I
K
-
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
---
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
---
E
D
L
T
V
K
I
G
D
F
G
L
A
T
V
-----------------
L
S
G
S
I
L
W
M
A
P
E
V
I
R
M
Q
----
D
K
N
----
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
-
Q
I
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
-
L
L
A
R
S
L
P
K
------------------------------
44
PsiBlast_CBE
87.06
73%
-121
- C1 -
4G9R
1
B:
[29-302]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
--
G
--------
D
--
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
-
R
-
H
V
N
I
L
L
F
M
G
Y
-
S
-
T
-
K
-
P
--
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
I
-------
E
T
--------
K
--
F
-
E
M
I
K
-
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
---
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
---
E
D
L
T
V
K
I
G
D
F
G
L
A
T
E
--
K
----------------
G
S
I
L
W
M
A
P
E
V
I
R
M
Q
----
D
K
N
----
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
-
Q
I
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
-
L
L
A
R
S
L
--------------------------------
47
PsiBlast_CBE
87.03
73%
-126
- C1 -
4EHG
1
BRAF_HUMAN
A:
[29-304]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
--
G
--------
D
--
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
-
R
-
H
V
N
I
L
L
F
M
G
Y
-
S
-
T
-
K
-
P
--
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
I
-------
E
T
--------
K
--
F
-
E
M
I
K
-
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
---
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
---
E
D
L
T
V
K
I
G
D
F
G
L
A
T
E
-------------------
G
S
I
L
W
M
A
P
E
V
I
R
M
Q
----
D
K
N
----
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
-
Q
I
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
-
L
L
A
R
S
L
P
K
------------------------------
5
PsiBlast_PDB
86.94
74%
-125
- C1 -
3PPJ
1
BRAF_HUMAN
A:
[29-304]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
--
G
--------
D
--
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
-
R
-
H
V
N
I
L
L
F
M
G
Y
-
S
-
T
-
K
-
P
--
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
I
-------
E
T
--------
K
--
F
-
E
M
I
K
-
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
---
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
---
E
D
L
T
V
K
I
G
D
F
G
L
A
T
V
-------------------
G
S
I
L
W
M
A
P
E
V
I
R
M
Q
----
D
K
N
----
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
-
Q
I
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
-
L
L
A
R
S
L
P
K
------------------------------
58
PsiBlast_CBE
86.84
72%
-123
- C1 -
4JVG
1
D:
[9-282]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
--
G
--------
D
--
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
-
R
-
H
V
N
I
L
L
F
M
G
Y
-
S
-
T
-
K
-
P
--
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
A
S
-------
E
T
--------
K
--
F
-
E
M
K
K
-
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
A
---
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
---
E
D
N
T
V
K
I
G
D
F
G
L
A
T
V
--
K
S
----------------
S
I
L
W
M
A
P
E
V
I
R
M
Q
----
D
S
N
----
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
-
Q
I
I
E
M
V
G
R
G
S
L
S
P
D
L
S
K
V
R
S
N
C
P
K
R
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
S
F
P
R
I
L
A
E
I
E
-
E
L
A
R
E
L
S
-------------------------------
48
PsiBlast_CBE
86.79
74%
-122
- C1 -
4MBJ
1
B:
[29-304]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
--
G
--------
D
--
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
-
R
-
H
V
N
I
L
L
F
M
G
Y
-
S
-
T
-
K
-
P
--
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
I
-------
E
T
--------
K
--
F
-
E
M
I
K
-
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
---
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
---
E
D
L
T
V
K
I
G
D
F
G
L
A
T
V
--
K
S
R
W
S
G
S
-
H
--
Q
F
E
Q
L
S
G
S
I
L
W
M
A
P
E
V
I
R
M
Q
----
D
K
N
----
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
-
Q
I
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
-
L
L
A
R
S
L
P
K
------------------------------
56
PsiBlast_CBE
86.74
76%
-119
- C1 -
1UWJ
1
B:
[3-276]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
--
G
--------
D
--
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
-
R
-
H
V
N
I
L
L
F
M
G
Y
-
S
-
T
-
K
-
P
--
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
I
-------
E
T
--------
K
--
F
-
E
M
I
K
-
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
---
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
---
E
D
L
T
V
K
I
G
D
F
G
L
A
T
E
--
K
----------------
G
S
I
L
W
M
A
P
E
V
I
R
M
Q
----
D
K
N
----
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
-
Q
I
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
-
L
L
A
R
S
L
P
K
------------------------------
33
PsiBlast_CBE
86.55
74%
-124
- C1 -
3PRI
1
B:
[29-304]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
--
G
--------
D
--
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
-
R
-
H
V
N
I
L
L
F
M
G
Y
-
S
-
T
-
K
-
P
--
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
I
-------
E
T
--------
K
--
F
-
E
M
I
K
-
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
---
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
---
E
D
L
T
V
K
I
G
D
F
G
L
A
T
V
-----------------
L
S
G
S
I
L
W
M
A
P
E
V
I
R
M
Q
----
D
K
N
----
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
-
Q
I
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
-
L
L
A
R
S
L
P
K
------------------------------
8
PsiBlast_PDB
86.54
74%
-124
- C1 -
3PRI
1
BRAF_HUMAN
A:
[29-304]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
--
G
--------
D
--
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
-
R
-
H
V
N
I
L
L
F
M
G
Y
-
S
-
T
-
K
-
P
--
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
I
-------
E
T
--------
K
--
F
-
E
M
I
K
-
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
---
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
---
E
D
L
T
V
K
I
G
D
F
G
L
A
T
V
-----------------
L
S
G
S
I
L
W
M
A
P
E
V
I
R
M
Q
----
D
K
N
----
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
-
Q
I
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
-
L
L
A
R
S
L
P
K
------------------------------
30
PsiBlast_CBE
86.48
74%
-118
- C1 -
3SKC
1
B:
[29-304]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
--
G
--------
D
--
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
-
R
-
H
V
N
I
L
L
F
M
G
Y
-
S
-
T
-
K
-
P
--
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
I
-------
E
T
--------
K
--
F
-
E
M
I
K
-
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
---
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
---
E
D
L
T
V
K
I
G
D
F
G
L
A
T
V
--
K
S
R
W
S
G
S
-
H
--
Q
F
E
Q
L
S
G
S
I
L
W
M
A
P
E
V
I
R
M
Q
----
D
K
N
----
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
-
Q
I
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
-
L
L
A
R
S
L
P
K
------------------------------
61
PsiBlast_CBE
86.33
72%
-124
- C1 -
4JVG
1
BRAF_HUMAN
A:
[9-282]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
--
G
--------
D
--
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
-
R
-
H
V
N
I
L
L
F
M
G
Y
-
S
-
T
-
K
-
P
--
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
A
S
-------
E
T
--------
K
--
F
-
E
M
K
K
-
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
A
---
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
---
E
D
N
T
V
K
I
G
D
F
G
L
A
T
V
--
K
S
----------------
S
I
L
W
M
A
P
E
V
I
R
M
Q
----
D
S
N
----
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
-
Q
I
I
E
M
V
G
R
G
S
L
S
P
D
L
S
K
V
R
S
N
C
P
K
R
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
S
F
P
R
I
L
A
E
I
E
-
E
L
A
R
E
L
S
-------------------------------
59
PsiBlast_CBE
86.16
72%
-123
- C1 -
4JVG
1
BRAF_HUMAN
C:
[9-282]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
--
G
--------
D
--
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
-
R
-
H
V
N
I
L
L
F
M
G
Y
-
S
-
T
-
K
-
P
--
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
A
S
-------
E
T
--------
K
--
F
-
E
M
K
K
-
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
A
---
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
---
E
D
N
T
V
K
I
G
D
F
G
L
A
----------------------
S
I
L
W
M
A
P
E
V
I
R
M
Q
----
D
S
N
----
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
-
Q
I
I
E
M
V
G
R
G
S
L
S
P
D
L
S
K
V
R
S
N
C
P
K
R
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
S
F
P
R
I
L
A
E
I
E
-
E
L
A
R
E
L
S
-------------------------------
26
PsiBlast_CBE
85.94
74%
-122
- C1 -
4E4X
1
B:
[29-302]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
--
G
--------
D
--
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
-
R
-
H
V
N
I
L
L
F
M
G
Y
-
S
-
T
-
K
-
P
--
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
I
-------
E
T
--------
K
--
F
-
E
M
I
K
-
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
---
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
---
E
D
L
T
V
K
I
G
D
F
G
L
A
T
V
--
K
S
R
W
S
G
S
-
H
--
Q
F
E
Q
L
S
G
S
I
L
W
M
A
P
E
V
I
R
M
Q
----
D
K
N
----
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
-
Q
I
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
-
L
L
A
R
S
L
--------------------------------
23
PsiBlast_CBE
85.89
74%
-123
- C1 -
4PP7
1
B:
[29-302]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
--
G
--------
D
--
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
-
R
-
H
V
N
I
L
L
F
M
G
Y
-
S
-
T
-
K
-
P
--
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
I
-------
E
T
--------
K
--
F
-
E
M
I
K
-
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
---
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
---
E
D
L
T
V
K
I
G
D
F
G
L
A
T
V
--
K
S
R
W
S
G
S
-
H
--
Q
F
E
Q
L
S
G
S
I
L
W
M
A
P
E
V
I
R
M
Q
----
D
K
N
----
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
-
Q
I
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
-
L
L
A
R
S
L
--------------------------------
57
PsiBlast_CBE
85.68
76%
-121
- C1 -
1UWJ
1
BRAF_HUMAN
A:
[3-276]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
--
G
--------
D
--
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
-
R
-
H
V
N
I
L
L
F
M
G
Y
-
S
-
T
-
K
-
P
--
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
I
-------
E
T
--------
K
--
F
-
E
M
I
K
-
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
---
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
---
E
D
L
T
V
K
I
G
D
F
G
L
A
T
E
--
K
S
---------------
G
S
I
L
W
M
A
P
E
V
I
R
M
Q
----
D
K
N
----
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
-
Q
I
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
-
L
L
A
R
S
L
P
K
------------------------------
63
PsiBlast_CBE
84.73
72%
-119
- C1 -
3C4C
1
BRAF_HUMAN
A:
[5-278]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
--
G
--------
D
--
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
-
R
-
H
V
N
I
L
L
F
M
G
Y
-
S
-
T
-
K
-
P
--
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
A
S
-------
E
T
--------
K
--
F
-
E
M
K
K
-
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
A
---
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
---
E
D
N
T
V
K
I
G
D
F
G
----------------------
S
G
S
I
L
W
M
A
P
E
V
I
R
M
Q
----
D
S
N
----
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
-
Q
I
I
E
M
V
G
R
G
S
L
S
P
D
L
S
K
V
R
S
N
C
P
K
R
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
S
F
P
R
I
L
A
E
I
E
-
E
L
A
R
E
L
S
-------------------------------
45
PsiBlast_CBE
83.64
73%
-121
- C1 -
4G9R
1
BRAF_HUMAN
A:
[29-302]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
--
G
--------
D
--
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
-
R
-
H
V
N
I
L
L
F
M
G
Y
-
S
-
T
-
K
-
P
--
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
I
-------
E
T
--------
K
--
F
-
E
M
I
K
-
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
---
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
---
E
D
L
T
V
K
I
G
D
F
G
L
A
T
E
--
K
S
---------------
G
S
I
L
W
M
A
P
E
V
I
R
M
Q
----
D
K
N
----
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
-
Q
I
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
-
L
L
A
R
S
L
--------------------------------
118
HHSearch
70.91
34%
-109
- C1 -
1T46
1
?
A:
[17-306]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
E
F
P
R
N
R
L
S
F
G
K
T
L
G
A
G
A
F
G
K
V
V
E
A
T
A
Y
--
G
LIKSD
A
A
M
T
--
V
A
V
K
M
L
K
P
S
A
-
H
L
T
E
R
E
A
L
M
S
E
L
K
V
L
S
Y
L
G
N
-
H
M
N
I
V
N
L
L
G
A
-
C
-
T
I
G
-
G
--
P
T
L
V
I
T
E
Y
C
C
Y
G
D
L
L
N
F
L
R
R
K
R
DSF----
L
--------
A
--
L
-
D
L
E
D
-
L
L
S
F
S
Y
Q
V
A
K
G
M
A
F
L
A
S
---
K
N
--
C
I
H
R
D
L
A
A
R
N
I
L
L
T
---
H
G
R
I
T
K
I
C
D
F
G
L
A
R
D
--
I
K
N
D
S
N
Y
-
V
--
V
K
G
N
A
R
L
P
V
K
W
M
A
P
E
S
I
F
N
-------
C
----
V
Y
T
F
E
S
D
V
W
S
Y
G
I
F
L
W
E
L
F
S
L
G
S
S
P
Y
P
G
M
P
V
D
S
-
K
F
Y
K
M
I
K
E
G
F
R
M
L
S
----
P
E
H
A
P
A
E
M
Y
D
I
M
K
T
C
W
D
A
D
P
L
K
R
P
T
F
K
Q
I
V
Q
L
I
E
-
K
Q
I
S
E
S
T
N
------------------------------
69
PsiBlast_CBE
68.92
34%
-129
- C1 -
3P86
1
CTR1_ARATH
A:
[33-298]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
I
P
W
C
D
L
N
I
K
E
K
I
G
A
G
S
F
G
T
V
H
R
A
E
W
H
--
G
S
-------
D
--
V
A
V
K
I
L
M
E
Q
D
F
H
A
E
R
V
N
E
F
L
R
E
V
A
I
M
K
R
L
-
R
-
H
P
N
I
V
L
F
M
G
A
-
V
-
T
-
Q
P
P
--
N
L
S
I
V
T
E
Y
L
S
R
G
S
L
Y
R
L
L
H
K
S
-------
G
A
--------
R
E
Q
L
-
D
E
R
R
-
R
L
S
M
A
Y
D
V
A
K
G
M
N
Y
L
H
N
---
R
N
P
P
I
V
H
R
N
L
K
S
P
N
L
L
V
D
---
K
K
Y
T
V
K
V
C
D
F
------------------------
G
T
P
E
W
M
A
P
E
V
L
R
D
E
-----------
P
S
N
E
K
S
D
V
Y
S
F
G
V
I
L
W
E
L
A
T
-
L
Q
Q
P
W
G
N
L
N
P
A
--
Q
V
V
A
A
V
G
---
F
K
C
K
R
L
E
I
P
R
N
L
N
P
Q
V
A
A
I
I
E
G
C
W
T
N
E
P
W
K
R
P
S
F
A
T
I
M
D
L
L
R
P
L
I
K
-----------------------------------
131
HHSearch
67.53
34%
-118
- C1 -
3KUL
2
EPHA8_HUMAN
A:
[43-316]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
R
E
I
E
A
S
R
I
H
I
E
K
I
I
G
S
G
D
S
G
E
V
C
Y
G
R
L
R
V
P
G
Q
R
D
V
----
P
--
V
A
I
K
A
L
K
A
G
-
Y
T
E
R
Q
R
R
D
F
L
S
E
A
S
I
M
G
Q
F
-
D
-
H
P
N
I
I
R
L
E
G
V
-
V
-
T
-
R
-
G
R-
L
A
M
I
V
T
E
Y
M
E
N
G
S
L
D
T
F
L
R
T
H
-------
D
G
--------
Q
--
F
-
T
I
M
Q
-
L
V
G
M
L
R
G
V
G
A
G
M
R
Y
L
S
D
---
L
G
--
Y
V
H
R
D
L
A
A
R
N
V
L
V
D
---
S
N
L
V
C
K
V
S
D
F
G
L
S
R
V
--
L
E
----
A
A
Y
--
T
T
T
---
I
P
I
R
W
T
A
P
E
A
I
A
F
-------
R
----
T
F
S
S
A
S
D
V
W
S
F
G
V
V
M
W
E
V
L
A
Y
G
E
R
P
Y
W
N
M
T
N
R
D
--
V
I
S
S
V
E
E
G
Y
R
L
P
A
----
P
M
G
C
P
H
A
L
H
Q
L
M
L
D
C
W
H
K
D
R
A
Q
R
P
R
F
S
Q
I
V
S
V
L
D
-
A
L
I
R
S
P
E
-------------------------------
124
HHSearch
66.16
31%
-114
- C1 -
2EVA
1
M3K7_HUMAN
A:
[2-279]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
H
M
I
D
Y
K
E
I
E
V
E
E
V
V
G
R
G
A
F
G
V
V
C
K
A
K
W
R
--
A
K
-------
D
--
V
A
I
K
Q
I
E
S
----
E
S
E
R
K
A
F
I
V
E
L
R
Q
L
S
R
V
-
N
-
H
P
N
I
V
K
L
Y
G
A
-
C
-
L
-
N
-
P
---
V
C
L
V
M
E
Y
A
E
G
G
S
L
Y
N
V
L
H
G
A
-------
E
P
L
P
------
Y
--
Y
-
T
A
A
H
-
A
M
S
W
C
L
Q
C
S
Q
G
V
A
Y
L
H
S
MQP
K
A
--
L
I
H
R
D
L
K
P
P
N
L
L
L
V
A--
G
G
T
V
L
K
I
C
D
F
G
T
----------------------
G
S
A
A
W
M
A
P
E
V
F
E
-------
G
S
----
N
Y
S
E
K
C
D
V
F
S
W
G
I
I
L
W
E
V
I
T
-
R
R
K
P
F
D
E
I
G
G
P
A
F
R
I
M
W
A
V
H
N
G
T
R
P
P
----
L
I
K
N
L
P
K
P
I
E
S
L
M
T
R
C
W
S
K
D
P
S
Q
R
P
S
M
E
E
I
V
K
I
M
T
-
H
L
M
R
Y
F
P
G
A
D
E
P
L
Q
Y
P
C
Q
H
S
L
P
P
G
E
D
G
R
V
E
P
Y
V
D
F
A
E
F
115
HHSearch
64.87
38%
-110
- C1 -
2Y4I
1
B:
[27-300]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
W
D
I
P
F
E
Q
L
E
I
G
E
L
I
G
K
G
R
F
G
Q
V
Y
H
G
R
W
H
--
G
--------
E
--
V
A
I
R
L
I
D
I
E
R
D
N
E
D
Q
L
K
A
F
K
R
E
V
M
A
Y
R
Q
T
-
R
-
H
E
N
V
V
L
F
M
G
A
-
C
M
S
-
P
-
P
--
H
L
A
I
I
T
S
L
C
K
G
R
T
L
Y
S
V
V
R
D
A
-------
K
I
--------
V
--
L
-
D
V
N
K
-
T
R
Q
I
A
Q
E
I
V
K
G
M
G
Y
L
H
A
---
K
G
--
I
L
H
K
D
L
K
S
K
N
V
F
Y
D
------
K
V
V
I
T
D
F
G
L
F
S
---------
E
-
D
--
K
L
R
I
Q
N
G
W
L
C
H
L
A
P
E
I
I
R
Q
L
SPDE
D
K
L
----
P
F
S
K
H
S
D
V
F
A
L
G
T
I
W
Y
E
L
H
A
-
R
E
W
P
F
K
T
Q
P
-
A
E
-
A
I
I
W
Q
M
G
T
G
M
K
-
P
N
L
S
Q
--
I
G
M
G
K
E
I
S
D
I
L
L
F
C
W
A
F
E
Q
E
E
R
P
T
F
T
K
L
M
D
M
L
E
-
K
----
L
--------------------------------
72
PsiBlast_CBE
64.63
34%
-117
- C1 -
4CSV
1
?
A:
[6-267]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
I
P
R
S
E
I
T
L
E
R
K
L
G
S
G
Q
F
G
E
V
Y
E
G
K
W
R
--
N
YN
I
-----
E
--
V
A
V
K
T
L
K
E
G
T
M
S
V
E
E
---
F
L
Q
E
A
Q
I
M
K
K
L
-
K
-
H
P
N
L
V
Q
L
Y
G
V
-
C
-
T
-
K
E
P
--
P
I
Y
I
I
T
E
Y
M
S
H
G
S
L
L
D
Y
L
R
D
C
----------------------
V
N
A
Q
A
L
L
D
M
A
A
Q
V
A
S
G
M
A
Y
L
E
S
---
Q
N
--
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
N
V
V
K
V
A
D
F
G
--------------------
F
P
---
I
K
W
T
A
P
E
A
I
S
Y
-------
N
----
R
F
S
I
K
S
D
V
W
A
F
G
I
L
L
W
E
I
F
T
Y
G
Q
V
P
Y
P
G
M
S
G
-
S
-
E
V
I
E
Q
V
E
R
G
Y
R
M
P
R
----
P
Q
G
C
P
E
E
I
Y
E
L
M
L
Q
C
W
N
K
S
P
E
E
R
P
T
F
A
E
T
L
H
A
L
E
-
T
M
F
L
----------------------------------
119
HHSearch
63.77
30%
-106
- C1 -
2XIR
1
A:
[21-310]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
E
F
P
R
D
R
L
K
L
G
K
P
L
G
R
G
A
F
G
Q
V
I
E
A
D
A
F
--
G
IDKTA
T
C
R
T
--
V
A
V
K
M
L
K
E
G
-
A
T
H
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
-
G
H
H
L
N
V
V
N
L
L
G
A
-
C
-
T
-
K
-
P
GG
P
L
M
V
I
V
E
F
C
K
F
G
N
L
S
T
Y
L
R
S
K
-------
R
N
EFVPYYKD
F
--
L
-
T
L
E
H
-
L
I
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
---
R
K
--
C
I
H
R
D
L
A
A
R
N
I
L
L
S
---
E
K
N
V
V
K
I
C
D
F
G
L
A
R
D
--
I
Y
K
D
P
D
Y
-
V
--
R
K
G
D
A
R
L
P
L
K
W
M
A
P
E
T
I
F
-------
D
R
----
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
G
A
S
P
Y
P
G
V
K
I
D
E
-
E
F
C
R
R
L
K
E
G
T
R
M
R
----
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
E
H
L
G
-
N
L
L
Q
A
N
A
-------------------------------
68
PsiBlast_CBE
62.75
36%
-108
- C1 -
2Y4I
1
B:
[28-300]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
D
I
P
F
E
Q
L
E
I
G
E
L
I
G
K
G
R
F
G
Q
V
Y
H
G
R
W
H
--
G
--------
E
--
V
A
I
R
L
I
D
I
E
R
D
N
E
D
Q
L
K
A
F
K
R
E
V
M
A
Y
R
Q
T
-
R
-
H
E
N
V
V
L
F
M
G
A
C
M
-
S
-
P
-
P
--
H
L
A
I
I
T
S
L
C
K
G
R
T
L
Y
S
V
V
R
D
A
-------
K
I
--------
V
--
L
-
D
V
N
K
-
T
R
Q
I
A
Q
E
I
V
K
G
M
G
Y
L
H
A
---
K
G
--
I
L
H
K
D
L
K
S
K
N
V
F
Y
D
-----
K
V
V
-
I
T
D
F
G
L
F
S
------------ED
K
L
R
I
Q
N
G
W
L
C
H
L
A
P
E
I
I
R
Q
L
----
S
P
D
EDKL
P
F
S
K
H
S
D
V
F
A
L
G
T
I
W
Y
E
L
H
A
-
R
E
W
P
F
K
-
T
Q
P
A
E
-
A
I
I
W
Q
M
G
T
G
-
M
K
P
N
L
S
Q
I
G
M
G
--
K
E
I
S
D
I
L
L
F
C
W
A
F
E
Q
E
E
R
P
T
F
T
K
L
M
D
M
L
E
-----
K
L
--------------------------------
95
PsiBlast_CBE
62.51
32%
-119
- C1 -
3OEZ
2
SRC_CHICK
A:
[13-270]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
I
P
R
E
S
L
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
--
G
--------
T
T
R
V
A
I
K
T
L
K
---
P
G
T
M
S
P
E
A
F
L
Q
E
A
Q
V
M
K
K
I
-
R
-
H
E
K
L
V
Q
L
Y
A
V
-
V
-
S
-
E
-
E
--
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
-------
M
G
--------
K
--
Y
L
R
L
P
Q
-
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
---
M
N
--
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
---
E
N
L
V
C
K
V
A
D
F
G
L
-------------------
F
P
---
I
K
W
T
A
P
E
A
A
L
Y
-------
G
----
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
--
V
L
D
Q
V
E
R
G
Y
R
M
P
----
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
-
D
Y
F
T
S
T
E
P
Q
Y
Q
P
G
E
N
L
----------------------
94
PsiBlast_CBE
62.31
32%
-115
- C1 -
3OEZ
1
SRC_CHICK
B:
[13-270]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
I
P
R
E
S
L
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
--
G
--------
T
T
R
V
A
I
K
T
L
K
---
P
G
T
M
S
P
E
A
F
L
Q
E
A
Q
V
M
K
K
I
-
R
-
H
E
K
L
V
Q
L
Y
A
V
-
V
-
S
-
E
-
E
--
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
-------
M
G
--------
K
--
Y
L
R
L
P
Q
-
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
---
M
N
--
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
---
E
N
L
V
C
K
V
A
D
F
G
--------------------
F
P
---
I
K
W
T
A
P
E
A
A
L
Y
-------
G
----
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
--
V
L
D
Q
V
E
R
G
Y
R
M
P
----
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
-
D
Y
F
T
S
T
E
P
Q
Y
Q
P
G
E
N
L
----------------------
93
PsiBlast_CBE
61.75
32%
-126
- C1 -
3QLF
1
SRC_CHICK
A:
[13-270]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
I
P
R
E
S
L
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
--
G
--------
T
T
R
V
A
I
K
T
L
K
------------
L
Q
E
A
Q
V
M
K
K
I
-
R
-
H
E
K
L
V
Q
L
Y
A
V
-
V
-
S
-
E
-
E
--
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
-------
M
G
--------
K
--
Y
L
R
L
P
Q
-
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
---
M
N
--
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
---
E
N
L
V
C
K
V
A
D
F
---------------------
F
P
---
I
K
W
T
A
P
E
A
A
L
Y
-------
G
----
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
--
V
L
D
Q
V
E
R
G
Y
R
M
P
----
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
-
D
Y
F
T
S
T
E
P
Q
Y
Q
P
G
E
N
L
----------------------
127
HHSearch
61.09
32%
-104
- C1 -
2I1M
1
A:
[40-326]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
E
F
P
R
N
N
L
Q
F
G
K
T
L
G
A
G
A
F
G
K
V
V
E
A
T
A
F
--
G
LGKEDAV
L
K
--
V
A
V
K
M
L
K
S
T
A
-
H
A
D
E
K
E
A
L
M
S
E
L
K
I
M
S
H
L
G
Q
-
H
E
N
I
V
N
L
L
G
A
-
C
-
T
-
H
G
G
--
P
V
L
V
I
T
E
Y
C
C
Y
G
D
L
L
N
F
L
R
R
K
S
R
V
L
ETD-
S
--------
T
--
A
-
S
T
R
D
-
L
L
H
F
S
S
Q
V
A
Q
G
M
A
F
L
A
S
---
K
N
--
C
I
H
R
D
V
A
A
R
N
V
L
L
T
---
N
G
H
V
A
K
I
G
D
F
G
L
A
R
D
--
I
M
N
D
S
N
Y
-
I
--
V
K
G
N
A
R
L
P
V
K
W
M
A
P
E
S
I
F
-------
D
C
----
V
Y
T
V
Q
S
D
V
W
S
Y
G
I
L
L
W
E
I
F
S
L
G
L
N
P
Y
P
G
I
L
V
N
S
-
K
F
Y
K
L
V
K
D
G
Y
Q
M
A
Q
----
P
A
F
A
P
K
N
I
Y
S
I
M
Q
A
C
W
A
L
E
P
T
H
R
P
T
F
Q
Q
I
C
S
F
L
Q
-
E
Q
A
Q
E
D
R
R
E
R
----------------------------
128
HHSearch
61.08
31%
-108
- C1 -
4CLJ
1
A:
[24-306]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
E
V
P
R
K
N
I
T
L
I
R
G
L
G
H
G
A
F
G
E
V
Y
E
G
Q
V
S
---P
L
------
Q
--
V
A
V
K
T
L
P
E
V
-
C
S
E
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
-
N
-
H
Q
N
I
V
R
C
I
G
V
-
S
-
L
-
Q
S
L
--
P
R
F
I
L
M
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
RPRPSQ-
P
S
--------
S
--
L
-
A
M
L
D
-
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
---
N
H
--
F
I
H
R
D
I
A
A
R
N
C
L
L
T
CPG
P
G
R
V
A
K
I
G
D
F
G
M
A
R
D
--
I
Y
R
---------
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
-------
E
G
----
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
M
P
Y
P
S
K
S
N
Q
E
-
V
-
L
E
F
V
T
S
G
G
R
-
M
D
---
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
R
I
E
-
Y
C
T
Q
D
P
D
V
I
N
T
A
L
P
I
E
Y
G
--------------------
78
PsiBlast_CBE
60.79
32%
-120
- C1 -
2BDJ
1
SRC_HUMAN
A:
[6-263]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
I
P
R
E
S
L
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
--
G
--------
T
T
R
V
A
I
K
T
L
K
---
P
G
T
M
S
P
E
A
F
L
Q
E
A
Q
V
M
K
K
L
-
R
-
H
E
K
L
V
Q
L
Y
A
V
-
V
-
S
-
E
-
E
--
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
-------
T
G
--------
K
--
Y
L
R
L
P
Q
-
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
---
M
N
--
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
---
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
IE--------------
F
P
---
I
K
W
T
A
P
E
A
A
L
Y
-------
G
----
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
--
V
L
D
Q
V
E
R
G
Y
R
M
P
----
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
-
D
Y
F
T
----------------------------------
97
PsiBlast_CBE
59.87
32%
-118
- C1 -
4U5J
1
SRC_CHICK
B:
[13-270]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
I
P
R
E
S
L
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
--
G
--------
T
TR
V
A
I
K
T
L
K
---
P
G
T
M
S
P
E
A
F
L
Q
E
A
Q
V
M
K
K
L
-
R
-
H
E
K
L
V
Q
L
Y
A
V
-
V
-
S
-
E
-
E
--
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
-------
M
G
--------
K
--
Y
L
R
L
P
Q
-
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
---
M
N
--
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
---
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
IE-----------
G
A
K
F
P
---
I
K
W
T
A
P
E
A
A
L
Y
-------
G
----
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
--
V
L
D
Q
V
E
R
G
Y
R
M
P
----
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
-
D
Y
F
T
S
T
E
P
Q
Y
Q
P
G
E
N
L
----------------------
98
PsiBlast_CBE
59.75
32%
-122
- C1 -
4U5J
1
SRC_CHICK
A:
[13-270]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
I
P
R
E
S
L
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
--
G
--------
T
T
R
V
A
I
K
T
L
K
---
P
G
T
M
S
P
E
A
F
L
Q
E
A
Q
V
M
K
K
L
-
R
-
H
E
K
L
V
Q
L
Y
A
V
-
V
-
S
-
E
-
E
--
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
-------
M
G
--------
K
--
Y
L
R
L
P
Q
-
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
---
M
N
--
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
---
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
IE-----------
G
A
K
F
P
---
I
K
W
T
A
P
E
A
A
L
Y
-------
G
----
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
--
V
L
D
Q
V
E
R
G
Y
R
M
P
----
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
-
D
Y
F
T
S
T
E
P
Q
Y
Q
P
G
E
N
L
----------------------
77
PsiBlast_CBE
59.35
32%
-115
- C1 -
2SRC
1
SRC_HUMAN
A:
[179-436]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
I
P
R
E
S
L
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
--
G
--------
T
T
R
V
A
I
K
T
L
K
---
P
G
T
M
S
P
E
A
F
L
Q
E
A
Q
V
M
K
K
L
-
R
-
H
E
K
L
V
Q
L
Y
A
V
-
V
-
S
-
E
-
E
--
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
-------
T
G
--------
K
--
Y
L
R
L
P
Q
-
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
---
M
N
--
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
---
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
IE
D
N
E
Y
T
A
R
-
Q
--
G
A
K
F
P
---
I
K
W
T
A
P
E
A
A
L
Y
-------
G
----
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
--
V
L
D
Q
V
E
R
G
Y
R
M
P
----
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
-
D
Y
F
T
S
T
E
P
Q
Y
Q
P
G
E
N
L
----------------------
71
PsiBlast_CBE
58.85
34%
-111
- C1 -
4UEU
1
?
A:
[6-267]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
I
P
R
S
E
I
T
L
E
R
K
L
G
S
G
Q
F
G
E
V
Y
E
G
K
W
R
--
N
YN
I
-----
E
--
V
A
V
K
T
L
K
E
G
T
M
S
V
E
E
---
F
L
Q
E
A
Q
I
M
K
K
L
-
K
-
H
P
N
L
V
Q
L
Y
G
V
-
C
-
T
-
K
E
P
--
P
I
Y
I
I
T
E
Y
M
S
H
G
S
L
L
D
Y
L
R
D
C
-------
E
G
--------
H
--
T
-
V
N
A
Q
A
L
L
D
M
A
A
Q
V
A
S
G
M
A
Y
L
E
S
---
Q
N
--
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
N
V
V
K
V
A
D
F
G
L
A
R
L
I-------------
A
K
F
P
---
I
K
W
T
A
P
E
A
I
S
Y
-------
N
----
R
F
S
I
K
S
D
V
W
A
F
G
I
L
L
W
E
I
F
T
Y
G
Q
V
P
Y
P
G
M
S
G
-
S
-
E
V
I
E
Q
V
E
R
G
Y
R
M
P
R
----
P
Q
G
C
P
E
E
I
Y
E
L
M
L
Q
C
W
N
K
S
P
E
E
R
P
T
F
A
E
T
L
H
A
L
E
-
T
M
F
-----------------------------------