@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : ARBK1_HUMAN: (2015-10-03 )
MADLEAVLADVSYLMAMEKSKATPAARASKKILLPEPSIRSVMQKYLEDRGEVTFEKIFSQKLGYLLFRDFCLNHLEEARPLVEFYEEIKKYEKLETEEERVARSREIFDSYIMKELLACSHPFSKSATEHVQGHLGKKQVPPDLFQPYIEEICQNLRGDVFQKFIESDKFTRFCQWKNVELNIHLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASVGTHGYMAPEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPDSFSPELRSLLEGLLQRDVNRRLGCLGRGAQEVKESPFFRSLDWQMVFLQKYPPPLIPPRGEVNAADAFDIGSFDEEDTKGIKLLDSDQELYRNFPLTISERWQQEVAETVFDTINAETDRLEARKKAKNKQLGHEEDYALGKDCIMHGYMSKMGNPFLTQWQRRYFYLFPNRLEWRGEGEAPQSLLTMEEIQSVEETQIKERKCLLLKIRGGKQFILQCDSDPELVQWKKELRDAYREAQQLVQRVPKMKNKPRSPVVELSKVPLVQRGSANGL
Atome Classification :
(67 SA)
.........10........20..--......---30--.----........40.--.......50.......-.-60........70........80----.----.......90........100......---.110.....-..-120.......130-.......140..--.....150.......160.......170.......180.......190.......200.......210-.---.---.......220.....-..230.-.....-.240.......250.......260.......270.......280-...----....----.--.290.......300.......310........320.......330.......340.--.---.--.-.-.-.-.350-........360........370.......380.......390.....-.--.-400........410.......420.......430.......440-........450.......460.......470.......480.......490..-.....---------500-------........510-........520..-.-....530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MA
D
L
E
A
V
L
A
D
V
S
Y
L
M
A
M
E
KSKAT--PAARAS---
K
---
K
----
I
LLP
E
P
S
I
R
S
V
--
M
Q
K
Y
L
E
DRGE
V
T
F
E
K
I
-
F
-
S
Q
K
L
G
Y
L
L
F
R
D
F
C
L
N
H
L
E
E
A
R
P
----
L
----
V
E
F
Y
E
E
I
K
K
Y
E
KLE
T
E
E
E
R
V
A
R
S
R
E
I
---
F
D
S
Y
I
M
K
E
L
-
L
A-CSHPFSKS
A
T
E
H
V
-
Q
G
HLGKKQV
P
P
D
--
L
F
Q
P
Y
I
E
E
I
C
Q
N
L
R
G
D
V
F
Q
K
F
I
E
SDKF
T
R
F
C
Q
W
K
N
V
E
L
N
I
H
L
T
MNDF
S
V
H
R
I
IGRGGFGEVYGCRK---A---D---TG
K
M
Y
A
M
K
C
L
D
K
K
R
I
-KMKQG
E
-
T
L
ALN-
E
R
I
M
L
S
L
VSTGDC
P
F
I
V
C
M
S
Y
AFHT
P
D
K
L
S
F
I
L
D
LMNGG
D
L
H
---
Y
H
L
----
S
QHG----V--F
S
E
A
D
M
R
F
Y
A
A
E
I
I
L
G
L
E
H
MHN-
R
F
V
V
Y
R
DLK
P
A
N
I
L
LDEHG
H
V
R
I
S
D
L
G
L
ACD-F--S---K--K-K-P-H-ASV--GTHGYM
A
P
E
-
V
L
Q
K
GVAYDSSA
D
W
F
S
L
G
C
M
L
F
K
L
L
RGHS
P
F
R
QHKTK-
D
--
K
-
H
-
E
I
D
R
M
T
L
T
M
A
V
ELPDSF
S
P
E
L
R
S
L
L
E
G
L
L
Q
R
D
V
N
R
R
L
G
CL-G-R
G
A
Q
E
V
K
ESPFFRSLD
W
Q
M
V
F
L
QKYPPPLIPPRGEVNAADAFDIGSFDEEDTK-
G
I
K
LL---------DS--------
D
Q
E
L
Y
R
NFP-L-
T
I
S
E
R
W
Q
Q
E
V
A
E
T
-
V
-
F
D
TINA
E
T
D
R
L
E
A
R
K
KAKNKQLGHEEDYAL
G
K
D
C
I
M
H
G
Y
M
S
KMG
N
P
F
L
T
Q
W
Q
R
R
Y
F
Y
LFPN
R
L
E
WRGEGEA
P
Q
S
L
L
T
M
E
E
I
Q
S
V
E
E
T
Q
IKER
K
C
L
L
L
K
IRGG
K
Q
F
I
L
QCDSD
P
E
L
V
Q
W
K
K
E
L
R
D
A
Y
R
E
A
Q
Q
L
V
Q
R
V
P
K
MKNKPRSP
V
V
ELSKV
P
L
V
QRGSANGL
3
PsiBlast_PDB
98.25
100%
-108
- C1 -
3KRW
1
ARBK1_HUMAN
A:
[29-670]
----------------------------------
K
---
K
----
I
L
L
P
E
P
S
I
R
S
V
--
M
Q
K
Y
L
E
D
R
G
E
V
T
F
E
K
I
-
F
-
S
Q
K
L
G
Y
L
L
F
R
D
F
C
L
N
H
L
E
E
A
R
P
----
L
----
V
E
F
Y
E
E
I
K
K
Y
E
K
L
E
T
E
E
E
R
V
A
R
S
R
E
I
---
F
D
S
Y
I
M
K
E
L
-
L
A
---
H
P
F
S
K
S
A
T
E
H
V
-
Q
G
H
L
G
K
K
Q
V
P
P
D
--
L
F
Q
P
Y
I
E
E
I
C
Q
N
L
R
G
D
V
F
Q
K
F
I
E
S
D
K
F
T
R
F
C
Q
W
K
N
V
E
L
N
I
H
L
T
M
N
D
F
S
V
H
R
I
I
G
R
G
G
F
G
E
V
Y
G
C
R
K
---
A
---
D
---
T
G
K
M
Y
A
M
K
C
L
D
K
K
R
I
-
K
M
K
Q
G
E
-
T
L
A
L
N
-
E
R
I
M
L
S
L
V
S
T
G
D
C
P
F
I
V
C
M
S
Y
A
F
H
T
P
D
K
L
S
F
I
L
D
L
M
N
G
G
D
L
H
---
Y
H
L
----
S
Q
H
G
----
V
--
F
S
E
A
D
M
R
F
Y
A
A
E
I
I
L
G
L
E
H
M
H
N
-
R
F
V
V
Y
R
D
L
K
P
A
N
I
L
L
D
E
H
G
H
V
R
I
S
D
L
G
L
A
C
D
-
F
--
S
---
K
--
K
-
K
-
P
-
H
-
A
S
V
--
G
T
H
G
Y
M
A
P
E
-
V
L
Q
K
G
V
A
Y
D
S
S
A
D
W
F
S
L
G
C
M
L
F
K
L
L
R
G
H
S
P
F
R
Q
H
K
T
K
-
D
--
K
-
H
-
E
I
D
R
M
T
L
T
M
A
V
E
L
P
D
S
F
S
P
E
L
R
S
L
L
E
G
L
L
Q
R
D
V
N
R
R
L
G
C
L
-
G
-
R
G
A
Q
E
V
K
E
S
P
F
F
R
S
L
D
W
Q
M
V
F
L
Q
K
Y
P
P
P
L
I
P
P
R
---------------
E
E
D
T
K
-
G
I
K
L
L
---------
D
S
--------
D
Q
E
L
Y
R
N
F
P
-
L
-
T
I
S
E
R
W
Q
Q
E
V
A
E
T
-
V
-
F
D
T
I
N
A
E
T
D
R
L
E
A
R
K
K
A
K
N
K
Q
L
G
H
E
E
D
Y
A
L
G
K
D
C
I
M
H
G
Y
M
S
K
M
-------
W
Q
R
R
Y
F
Y
L
F
P
N
R
L
E
W
R
G
E
G
E
A
P
Q
S
L
L
T
M
E
E
I
Q
S
V
E
E
T
Q
I
K
E
R
K
C
L
L
L
K
I
R
G
G
K
Q
F
I
L
Q
C
D
S
D
P
E
L
V
Q
W
K
K
E
L
R
D
A
Y
R
E
A
Q
Q
L
V
Q
R
V
P
K
M
K
N
K
P
R
S
P
------------------
4
PsiBlast_PDB
98.03
100%
-106
- C1 -
3KRX
1
ARBK1_HUMAN
A:
[29-670]
----------------------------------
K
---
K
----
I
L
L
P
E
P
S
I
R
S
V
--
M
Q
K
Y
L
E
D
R
G
E
V
T
F
E
K
I
-
F
-
S
Q
K
L
G
Y
L
L
F
R
D
F
C
L
N
H
L
E
E
A
R
P
----
L
----
V
E
F
Y
E
E
I
K
K
Y
E
K
L
E
T
E
E
E
R
V
A
R
S
R
E
I
---
F
D
S
Y
I
M
K
E
L
-
L
A
---
H
P
F
S
K
S
A
T
E
H
V
-
Q
G
H
L
G
K
K
Q
V
P
P
D
--
L
F
Q
P
Y
I
E
E
I
C
Q
N
L
R
G
D
V
F
Q
K
F
I
E
S
D
K
F
T
R
F
C
Q
W
K
N
V
E
L
N
I
H
L
T
M
N
D
F
S
V
H
R
I
I
G
R
G
G
F
G
E
V
Y
G
C
R
K
---
A
---
D
---
T
G
K
M
Y
A
M
K
C
L
D
K
K
R
I
-
K
M
K
Q
G
E
-
T
L
A
L
N
-
E
R
I
M
L
S
L
V
S
T
G
D
C
P
F
I
V
C
M
S
Y
A
F
H
T
P
D
K
L
S
F
I
L
D
L
M
N
G
G
D
L
H
---
Y
H
L
----
S
Q
H
G
----
V
--
F
S
E
A
D
M
R
F
Y
A
A
E
I
I
L
G
L
E
H
M
H
N
-
R
F
V
V
Y
R
D
L
K
P
A
N
I
L
L
D
E
H
G
H
V
R
I
S
D
L
G
L
A
C
D
-
F
--
S
---
K
--
K
-
K
-
P
-
H
-
A
S
V
--
G
T
H
G
Y
M
A
P
E
-
V
L
Q
K
G
V
A
Y
D
S
S
A
D
W
F
S
L
G
C
M
L
F
K
L
L
R
G
H
S
P
F
R
Q
H
K
T
K
-
D
--
K
-
H
-
E
I
D
R
M
T
L
T
M
A
V
E
L
P
D
S
F
S
P
E
L
R
S
L
L
E
G
L
L
Q
R
D
V
N
R
R
L
G
C
L
-
G
-
R
G
A
Q
E
V
K
E
S
P
F
F
R
S
L
D
W
Q
M
V
F
L
Q
K
Y
P
P
P
L
I
P
P
R
---------------
E
E
D
T
K
-
G
I
K
L
L
---------
D
S
--------
D
Q
E
L
Y
R
N
F
P
-
L
-
T
I
S
E
R
W
Q
Q
E
V
A
E
T
-
V
-
F
D
T
I
N
A
E
T
D
R
L
E
A
R
K
K
A
K
N
K
Q
L
G
H
E
E
D
Y
A
L
G
K
D
C
I
M
H
G
Y
M
S
K
M
-------
W
Q
R
R
Y
F
Y
L
F
P
N
R
L
E
W
R
G
E
G
E
A
P
Q
S
L
L
T
M
E
E
I
Q
S
V
E
E
T
Q
I
K
E
R
K
C
L
L
L
K
I
R
G
G
K
Q
F
I
L
Q
C
D
S
D
P
E
L
V
Q
W
K
K
E
L
R
D
A
Y
R
E
A
Q
Q
L
V
Q
R
V
P
K
M
K
N
K
P
R
S
P
------------------
13
PsiBlast_PDB
97.57
100%
-107
- C1 -
4MK0
2
ARBK1_HUMAN
A:
[1-639]
----------------------------------
K
---
K
----
I
L
L
P
E
P
S
I
R
S
V
--
M
Q
K
Y
L
E
D
R
G
E
V
T
F
E
K
I
-
F
-
S
Q
K
L
G
Y
L
L
F
R
D
F
C
L
N
H
L
E
E
A
R
P
----
L
----
V
E
F
Y
E
E
I
K
K
Y
E
K
L
E
T
E
E
E
R
V
A
R
S
R
E
I
---
F
D
S
Y
I
M
K
E
L
-
L
A
-
C
S
H
P
F
S
K
S
A
T
E
H
V
-
Q
G
H
L
G
K
K
Q
V
P
P
D
--
L
F
Q
P
Y
I
E
E
I
C
Q
N
L
R
G
D
V
F
Q
K
F
I
E
S
D
K
F
T
R
F
C
Q
W
K
N
V
E
L
N
I
H
L
T
M
N
D
F
S
V
H
R
I
I
G
R
G
G
F
G
E
V
Y
G
C
R
K
---
A
---
D
---
T
G
K
M
Y
A
M
K
C
L
D
K
K
R
I
-
K
M
K
Q
G
E
-
T
L
A
L
N
-
E
R
I
M
L
S
L
V
S
T
G
D
C
P
F
I
V
C
M
S
Y
A
F
H
T
P
D
K
L
S
F
I
L
D
L
M
N
G
G
D
L
H
---
Y
H
L
----
S
Q
H
G
----
V
--
F
S
E
A
D
M
R
F
Y
A
A
E
I
I
L
G
L
E
H
M
H
N
-
R
F
V
V
Y
R
D
L
K
P
A
N
I
L
L
D
E
H
G
H
V
R
I
S
D
L
G
L
A
C
D
-
F
--
S
---
K
--
K
-
K
-
P
-
H
-
A
S
V
--
G
T
H
G
Y
M
A
P
E
-
V
L
Q
K
G
V
A
Y
D
S
S
A
D
W
F
S
L
G
C
M
L
F
K
L
L
R
G
H
S
P
F
R
Q
H
K
T
K
-
D
--
K
-
H
-
E
I
D
R
M
T
L
T
M
A
V
E
L
P
D
S
F
S
P
E
L
R
S
L
L
E
G
L
L
Q
R
D
V
N
R
R
L
G
C
L
-
G
-
R
G
A
Q
E
V
K
E
S
P
F
F
R
S
L
D
W
Q
M
V
F
L
Q
K
Y
P
P
P
L
I
P
P
R
G
E
V
N
A
A
D
A
F
---------
T
K
-
G
I
K
L
L
---------
D
S
--------
D
Q
E
L
Y
R
N
F
P
-
L
-
T
I
S
E
R
W
Q
Q
E
V
A
E
T
-
V
-
F
D
T
I
N
A
E
T
D
R
L
E
A
R
K
K
A
K
N
K
Q
L
G
H
E
E
D
Y
A
L
G
K
D
C
I
M
H
G
Y
M
S
K
M
G
N
P
F
L
T
Q
W
Q
R
R
Y
F
Y
L
F
P
N
R
L
E
W
R
G
E
G
E
A
P
Q
S
L
L
T
M
E
E
I
Q
S
V
E
E
T
Q
I
K
E
R
K
C
L
L
L
K
I
R
G
G
K
Q
F
I
L
Q
C
D
S
D
P
E
L
V
Q
W
K
K
E
L
R
D
A
Y
R
E
A
Q
Q
L
V
Q
R
V
P
K
M
K
N
K
P
A
--------------------
11
PsiBlast_PDB
97.42
98%
-111
- C1 -
3PVU
1
ARBK1_BOVIN
A:
[30-668]
----------------------------------
K
---
K
----
I
L
L
P
E
P
S
I
R
S
V
--
M
Q
K
Y
L
E
D
R
G
E
V
T
F
E
K
I
-
F
-
S
Q
K
L
G
Y
L
L
F
R
D
F
C
L
K
H
L
E
E
A
K
P
----
L
----
V
E
F
Y
E
E
I
K
K
Y
E
K
L
E
T
E
E
E
R
L
V
C
S
R
E
I
---
F
D
T
Y
I
M
K
E
L
-
L
A
-
C
S
H
P
F
S
K
S
A
I
E
H
V
-
Q
G
H
L
V
K
K
Q
V
P
P
D
--
L
F
Q
P
Y
I
E
E
I
C
Q
N
L
R
G
D
V
F
Q
K
F
I
E
S
D
K
F
T
R
F
C
Q
W
K
N
V
E
L
N
I
H
L
T
M
N
D
F
S
V
H
R
I
I
G
R
G
G
F
G
E
V
Y
G
C
R
K
---
A
---
D
---
T
G
K
M
Y
A
M
K
C
L
D
K
K
R
I
-
K
M
K
Q
G
E
-
T
L
A
L
N
-
E
R
I
M
L
S
L
V
S
T
G
D
C
P
F
I
V
C
M
S
Y
A
F
H
T
P
D
K
L
S
F
I
L
D
L
M
N
G
G
D
L
H
---
Y
H
L
----
S
Q
H
G
----
V
--
F
S
E
A
D
M
R
F
Y
A
A
E
I
I
L
G
L
E
H
M
H
N
-
R
F
V
V
Y
R
D
L
K
P
A
N
I
L
L
D
E
H
G
H
V
R
I
S
D
L
G
L
A
C
D
-
F
--
S
---
K
--
K
-
K
-
P
-
H
-
A
S
V
--
G
T
H
G
Y
M
A
P
E
-
V
L
Q
K
G
V
A
Y
D
S
S
A
D
W
F
S
L
G
C
M
L
F
K
L
L
R
G
H
S
P
F
R
Q
H
K
T
K
-
D
--
K
-
H
-
E
I
D
R
M
T
L
T
M
A
V
E
L
P
D
S
F
S
P
E
L
R
S
L
L
E
G
L
L
Q
R
D
V
N
R
R
L
G
C
L
-
G
-
R
G
A
Q
E
V
K
E
S
P
F
F
R
S
L
D
W
Q
M
V
F
L
Q
K
Y
P
P
P
L
I
P
P
R
G
----------------------------------
D
S
--------
D
Q
E
L
Y
R
N
F
P
-
L
-
T
I
S
E
R
W
Q
Q
E
V
A
E
T
-
V
-
F
D
T
I
N
A
E
T
D
R
L
E
A
R
K
K
T
K
N
K
Q
L
G
H
E
E
D
Y
A
L
G
K
D
C
I
M
H
G
Y
M
S
K
M
G
------
W
Q
R
R
Y
F
Y
L
F
P
N
R
L
E
W
R
G
E
G
E
A
P
Q
S
L
L
T
M
E
E
I
Q
S
V
E
E
T
Q
I
K
E
R
K
C
L
L
L
K
I
R
G
G
K
Q
F
V
L
Q
C
D
S
D
P
E
L
V
Q
W
K
K
E
L
R
D
A
Y
R
E
A
Q
Q
L
V
Q
R
V
P
K
M
K
N
K
P
---------------------
12
PsiBlast_PDB
96.94
98%
-109
- C1 -
3PVW
1
ARBK1_BOVIN
A:
[29-668]
------------------------------
S
---
K
---
K
----
I
L
L
P
E
P
S
I
R
S
V
--
M
Q
K
Y
L
E
D
R
G
E
V
T
F
E
K
I
-
F
-
S
Q
K
L
G
Y
L
L
F
R
D
F
C
L
K
H
L
E
E
A
K
P
----
L
----
V
E
F
Y
E
E
I
K
K
Y
E
K
L
E
T
E
E
E
R
L
V
C
S
R
E
I
---
F
D
T
Y
I
M
K
E
L
-
L
A
-
C
S
H
P
F
S
K
S
A
I
E
H
V
-
Q
G
H
L
V
K
K
Q
V
P
P
D
--
L
F
Q
P
Y
I
E
E
I
C
Q
N
L
R
G
D
V
F
Q
K
F
I
E
S
D
K
F
T
R
F
C
Q
W
K
N
V
E
L
N
I
H
L
T
M
N
D
F
S
V
H
R
I
I
G
R
G
G
F
G
E
V
Y
G
C
R
K
---
A
---
D
---
T
G
K
M
Y
A
M
K
C
L
D
K
K
R
I
-
K
M
K
Q
G
E
-
T
L
A
L
N
-
E
R
I
M
L
S
L
V
S
T
G
D
C
P
F
I
V
C
M
S
Y
A
F
H
T
P
D
K
L
S
F
I
L
D
L
M
N
G
G
D
L
H
---
Y
H
L
----
S
Q
H
G
----
V
--
F
S
E
A
D
M
R
F
Y
A
A
E
I
I
L
G
L
E
H
M
H
N
-
R
F
V
V
Y
R
D
L
K
P
A
N
I
L
L
D
E
H
G
H
V
R
I
S
D
L
G
L
A
C
D
-
F
--
S
---
K
--
K
-
K
-
P
-
H
-
A
S
V
--
G
T
H
G
Y
M
A
P
E
-
V
L
Q
K
G
V
A
Y
D
S
S
A
D
W
F
S
L
G
C
M
L
F
K
L
L
R
G
H
S
P
F
R
Q
H
K
T
K
-
D
--
K
-
H
-
E
I
D
R
M
T
L
T
M
A
V
E
L
P
D
S
F
S
P
E
L
R
S
L
L
E
G
L
L
Q
R
D
V
N
R
R
L
G
C
L
-
G
-
R
G
A
Q
E
V
K
E
S
P
F
F
R
S
L
D
W
Q
M
V
F
L
Q
K
Y
P
P
P
L
I
P
P
R
G
----------------------
K
L
L
---------
D
S
--------
D
Q
E
L
Y
R
N
F
P
-
L
-
T
I
S
E
R
W
Q
Q
E
V
A
E
T
-
V
-
F
D
T
I
N
A
E
T
D
R
L
E
A
R
K
K
T
K
N
K
Q
L
G
H
E
E
D
Y
A
L
G
K
D
C
I
M
H
G
Y
M
S
K
M
G
------
W
Q
R
R
Y
F
Y
L
F
P
N
R
L
E
W
R
G
E
G
E
A
P
Q
S
L
L
T
M
E
E
I
Q
S
V
E
E
T
Q
I
K
E
R
K
C
L
L
L
K
I
R
G
G
K
Q
F
V
L
Q
C
D
S
D
P
E
L
V
Q
W
K
K
E
L
R
D
A
Y
R
E
A
Q
Q
L
V
Q
R
V
P
K
M
K
N
K
P
---------------------
2
PsiBlast_PDB
96.89
100%
-107
- C1 -
4PNK
1
ARBK1_HUMAN
A:
[30-668]
----------------------------------
K
---
K
----
I
L
L
P
E
P
S
I
R
S
V
--
M
Q
K
Y
L
E
D
R
G
E
V
T
F
E
K
I
-
F
-
S
Q
K
L
G
Y
L
L
F
R
D
F
C
L
N
H
L
E
E
A
R
P
----
L
----
V
E
F
Y
E
E
I
K
K
Y
E
K
L
E
T
E
E
E
R
V
A
R
S
R
E
I
---
F
D
S
Y
I
M
K
E
L
-
L
A
-
C
S
H
P
F
S
K
S
A
T
E
H
V
-
Q
G
H
L
G
K
K
Q
V
P
P
D
--
L
F
Q
P
Y
I
E
E
I
C
Q
N
L
R
G
D
V
F
Q
K
F
I
E
S
D
K
F
T
R
F
C
Q
W
K
N
V
E
L
N
I
H
L
T
M
N
D
F
S
V
H
R
I
I
G
R
G
G
F
G
E
V
Y
G
C
R
K
---
A
---
D
---
T
G
K
M
Y
A
M
K
C
L
D
K
K
R
I
-
K
M
K
Q
G
E
-
T
L
A
L
N
-
E
R
I
M
L
S
L
V
S
T
G
D
C
P
F
I
V
C
M
S
Y
A
F
H
T
P
D
K
L
S
F
I
L
D
L
M
N
G
G
D
L
H
---
Y
H
L
----
S
Q
H
G
----
V
--
F
S
E
A
D
M
R
F
Y
A
A
E
I
I
L
G
L
E
H
M
H
N
-
R
F
V
V
Y
R
D
L
K
P
A
N
I
L
L
D
E
H
G
H
V
R
I
S
D
L
G
L
A
C
D
-
F
--
S
---
K
--
K
-
K
-
P
-
H
-
A
S
V
--
G
T
H
G
Y
M
A
P
E
-
V
L
Q
K
G
V
A
Y
D
S
S
A
D
W
F
S
L
G
C
M
L
F
K
L
L
R
G
H
S
P
F
R
Q
H
K
T
K
-
D
--
K
-
H
-
E
I
D
R
M
T
L
T
M
A
V
E
L
P
D
S
F
S
P
E
L
R
S
L
L
E
G
L
L
Q
R
D
V
N
R
R
L
G
C
L
-
G
-
R
G
A
Q
E
V
K
E
S
P
F
F
R
S
L
D
W
Q
M
V
F
L
Q
K
Y
P
P
P
L
I
P
P
R
-
E
V
N
A
-------------
T
K
-
G
I
K
L
L
---------
D
S
--------
D
Q
E
L
Y
R
N
F
P
-
L
-
T
I
S
E
R
W
Q
Q
E
V
A
E
T
-
V
-
F
D
T
I
N
A
E
T
D
R
L
E
A
R
K
K
A
K
N
K
Q
L
G
H
E
E
D
Y
A
L
G
K
D
C
I
M
H
G
Y
M
S
K
M
G
N
P
F
L
T
Q
W
Q
R
R
Y
F
Y
L
F
P
N
R
L
E
W
R
G
E
G
E
A
P
Q
S
L
L
T
M
E
E
I
Q
S
V
E
E
T
Q
I
K
E
R
K
C
L
L
L
K
I
R
G
G
K
Q
F
I
L
Q
C
D
S
D
P
E
L
V
Q
W
K
K
E
L
R
D
A
Y
R
E
A
Q
Q
L
V
Q
R
V
P
K
M
K
N
K
P
---------------------
85
Fugue
65.79
38%
-90
- C1 -
2ACX
1
GRK6_HUMAN
A:
[14-532]
------------------
K
A
R
K
G
--
K
S
K
K
W
R
---
Q
---
M
----
L
Q
F
P
H
I
S
Q
C
E
E
--
L
R
L
S
L
E
R
D
Y
H
S
L
C
E
R
-----
N
P
I
G
R
L
L
F
R
E
F
C
A
T
R
-
P
E
L
S
R
----
C
----
V
A
F
L
D
G
V
A
E
Y
E
-
V
T
P
D
D
K
R
K
A
C
G
R
N
L
---
T
Q
N
F
L
S
H
T
G
-
P
D
-
L
I
P
E
V
P
R
Q
L
V
T
N
C
-
T
Q
R
L
E
Q
G
P
C
K
-
D
--
L
F
Q
E
L
T
R
L
T
H
E
Y
L
S
V
A
P
F
A
D
Y
L
D
S
I
Y
F
N
R
F
L
Q
W
K
W
L
E
R
Q
-
P
V
T
K
N
T
F
R
Q
Y
R
V
L
G
K
G
G
F
G
E
V
C
A
C
Q
V
---
R
---
A
---
T
G
K
M
Y
A
C
K
K
L
E
K
K
R
I
-
K
K
R
K
G
E
-
A
M
A
L
N
-
E
K
Q
I
L
E
K
V
N
S
---
R
F
V
V
S
L
A
Y
A
Y
E
T
K
D
A
L
C
L
V
L
T
L
M
N
G
G
D
L
K
---
F
H
I
----
Y
H
M
G
Q
A
--
G
--
F
P
E
A
R
A
V
F
Y
A
A
E
I
C
C
G
L
E
D
L
H
R
-
E
R
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
D
H
G
H
I
R
I
S
D
L
G
L
A
V
H
-
V
--
P
---
E
--
G
-
Q
-
T
-
I
K
G
R
V
--
G
T
V
G
Y
M
A
P
E
-
V
V
-
K
N
E
R
Y
T
F
S
P
D
W
W
A
L
G
C
L
L
Y
E
M
I
A
G
Q
S
P
F
Q
Q
R
K
K
K
I
K
--
R
-
E
-
E
V
E
R
L
V
K
E
V
P
E
E
Y
S
E
R
F
S
P
Q
A
R
S
L
C
S
Q
L
L
C
K
D
P
A
E
R
L
G
C
R
-
G
-
G
S
A
R
E
V
K
E
H
P
L
F
K
K
L
N
F
K
R
L
G
A
G
M
L
E
P
P
F
K
P
D
P
Q
A
I
Y
C
E
-----------------------------
P
T
--------
D
Q
D
F
Y
Q
K
F
A
T
G
-
S
V
P
I
P
W
Q
N
E
M
V
E
T
-----------------------------------------------------------
E
C
F
Q
E
L
N
V
F
G
L
D
G
S
----------------------------------------------------------------------------------------------
37
PsiBlast_CBE
65.34
34%
-93
- C1 -
3C4W
1
RK_BOVIN
B:
[9-529]
------
V
V
A
N
S
A
F
I
A
A
R
G
S
F
D
A
S
SG
P
A
S
R
D
R
---
K
Y
L
A
R
----
L
K
L
P
P
L
S
K
C
E
A
--
L
R
E
S
L
D
----
L
G
F
E
G
M
C
L
-
E
Q
P
I
G
K
R
L
F
Q
Q
F
L
R
T
H
-
E
Q
H
G
P
----
A
----
L
Q
L
W
K
D
I
E
D
Y
D
T
A
D
-
D
A
L
R
P
Q
K
A
Q
A
L
---
R
A
A
Y
L
E
P
Q
A
Q
L
F
-
C
S
F
L
D
A
E
T
V
A
R
A
R
-
A
--------
G
D
G
--
L
F
Q
P
L
L
R
A
V
L
A
H
L
G
Q
A
P
F
Q
E
F
L
D
S
L
Y
F
L
R
F
L
Q
W
K
W
L
E
A
Q
-
P
M
G
E
D
W
F
L
D
F
R
V
L
G
R
G
G
F
G
E
V
F
A
C
Q
M
---
K
---
A
---
T
G
K
L
Y
A
C
K
K
L
N
K
K
R
L
-
K
K
R
K
G
Y
-
Q
G
A
M
V
-
E
K
K
I
L
A
K
V
H
S
---
R
F
I
V
S
L
A
Y
A
F
E
T
K
T
D
L
C
L
V
M
T
I
M
N
G
G
D
I
R
---
Y
H
I
Y
N
V
D
E
D
N
P
----
G
--
F
Q
E
P
R
A
I
F
Y
T
A
Q
I
V
S
G
L
E
H
L
H
Q
-
R
N
I
I
Y
R
D
L
K
P
E
N
V
L
L
D
D
D
G
N
V
R
I
S
D
L
G
L
A
V
E
-
L
K
A
G
---
Q
--
T
-
K
-
T
-
K
-
G
Y
A
--
G
T
P
G
F
M
A
P
E
-
L
L
L
-
G
E
E
Y
D
F
S
V
D
Y
F
A
L
G
V
T
L
Y
E
M
I
A
A
R
G
P
F
R
A
R
G
E
K
V
E
--
N
-
K
-
E
L
K
Q
R
V
L
E
Q
A
V
T
Y
P
D
K
F
S
P
A
S
K
D
F
C
E
A
L
L
Q
K
D
P
E
K
R
L
G
F
R
-
D
-
G
S
C
D
G
L
R
T
H
P
L
F
R
D
I
S
W
R
Q
L
E
A
G
M
L
T
P
P
F
V
P
D
S
R
T
V
Y
A
K
N
--------
T
--
V
K
-
G
V
A
F
E
---------
K
A
--------
D
T
E
F
F
Q
E
F
A
-
S
G
T
C
P
I
P
W
Q
E
E
M
I
E
T
G
V
-
F
G
D
L
N
V
W
R
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------
38
PsiBlast_CBE
64.89
34%
-97
- C1 -
3C4W
1
RK_BOVIN
A:
[31-529]
----------------------------
R
D
R
---
K
Y
L
A
R
----
L
K
L
P
P
L
S
K
C
E
A
--
L
R
E
S
L
D
----
L
G
F
E
G
M
C
L
-
E
Q
P
I
G
K
R
L
F
Q
Q
F
L
R
T
H
-
E
Q
H
G
P
----
A
----
L
Q
L
W
K
D
I
E
D
Y
D
T
A
D
-
D
A
L
R
P
Q
K
A
Q
A
L
---
R
A
A
Y
L
E
P
Q
A
Q
L
F
-
C
S
F
L
D
A
E
T
V
A
R
A
R
-
A
G
------
A
G
D
G
--
L
F
Q
P
L
L
R
A
V
L
A
H
L
G
Q
A
P
F
Q
E
F
L
D
S
L
Y
F
L
R
F
L
Q
W
K
W
L
E
A
Q
-
P
M
G
E
D
W
F
L
D
F
R
V
L
G
R
G
G
F
G
E
V
F
A
C
Q
M
---
K
---
A
---
T
G
K
L
Y
A
C
K
K
L
N
K
K
R
L
-
K
K
R
K
G
Y
-
Q
G
A
M
V
-
E
K
K
I
L
A
K
V
H
S
---
R
F
I
V
S
L
A
Y
A
F
E
T
K
T
D
L
C
L
V
M
T
I
M
N
G
G
D
I
R
---
Y
H
I
Y
N
VD
E
D
N
P
----
G
--
F
Q
E
P
R
A
I
F
Y
T
A
Q
I
V
S
G
L
E
H
L
H
Q
-
R
N
I
I
Y
R
D
L
K
P
E
N
V
L
L
D
D
D
G
N
V
R
I
S
D
L
G
L
A
V
E
-
L
K
A
G
---
Q
--
T
-
K
-
T
-
K
-
G
Y
A
--
G
T
P
G
F
M
A
P
E
-
L
L
L
-
G
E
E
Y
D
F
S
V
D
Y
F
A
L
G
V
T
L
Y
E
M
I
A
A
R
G
P
F
R
A
R
G
E
K
V
E
--
N
-
K
-
E
L
K
Q
R
V
L
E
Q
A
V
T
Y
P
D
K
F
S
P
A
S
K
D
F
C
E
A
L
L
Q
K
D
P
E
K
R
L
G
F
R
-
D
-
G
S
C
D
G
L
R
T
H
P
L
F
R
D
I
S
W
R
Q
L
E
A
G
M
L
T
P
P
F
V
P
D
---------
Q
D
V
G
A
F
S
T
--
V
K
-
G
V
A
F
E
---------
K
A
--------
D
T
E
F
F
Q
E
F
A
-
S
G
T
C
P
I
P
W
Q
E
E
M
I
E
T
G
V
-
F
G
D
L
N
V
W
R
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------
27
PsiBlast_CBE
64.89
34%
-97
- C1 -
3C4Z
1
RK_BOVIN
A:
[31-529]
----------------------------
R
D
R
---
K
Y
L
A
R
----
L
K
L
P
P
L
S
K
C
E
A
--
L
R
E
S
L
D
----
L
G
F
E
G
M
C
L
-
E
Q
P
I
G
K
R
L
F
Q
Q
F
L
R
T
H
-
E
Q
H
G
P
----
A
----
L
Q
L
W
K
D
I
E
D
Y
D
T
A
D
-
D
A
L
R
P
Q
K
A
Q
A
L
---
R
A
A
Y
L
E
P
Q
A
Q
L
F
-
C
S
F
L
D
A
E
T
V
A
R
A
R
-
A
G
---------
G
--
L
F
Q
P
L
L
R
A
V
L
A
H
L
G
Q
A
P
F
Q
E
F
L
D
S
L
Y
F
L
R
F
L
Q
W
K
W
L
E
A
Q
-
P
M
G
E
D
W
F
L
D
F
R
V
L
G
R
G
G
F
G
E
V
F
A
C
Q
M
---
K
---
A
---
T
G
K
L
Y
A
C
K
K
L
N
K
K
R
L
-
K
K
R
K
G
Y
-
Q
G
A
M
V
-
E
K
K
I
L
A
K
V
H
S
---
R
F
I
V
S
L
A
Y
A
F
E
T
K
T
D
L
C
L
V
M
T
I
M
N
G
G
D
I
R
---
Y
H
I
YNVD
E
D
N
P
----
G
--
F
Q
E
P
R
A
I
F
Y
T
A
Q
I
V
S
G
L
E
H
L
H
Q
-
R
N
I
I
Y
R
D
L
K
P
E
N
V
L
L
D
D
D
G
N
V
R
I
S
D
L
G
L
A
V
E
-
L
K
A
G
---
Q
--
T
-
K
-
T
-
K
-
G
Y
A
--
G
T
P
G
F
M
A
P
E
-
L
L
L
-
G
E
E
Y
D
F
S
V
D
Y
F
A
L
G
V
T
L
Y
E
M
I
A
A
R
G
P
F
R
A
R
G
E
K
V
E
--
N
-
K
-
E
L
K
Q
R
V
L
E
Q
A
V
T
Y
P
D
K
F
S
P
A
S
K
D
F
C
E
A
L
L
Q
K
D
P
E
K
R
L
G
F
R
-
D
-
G
S
C
D
G
L
R
T
H
P
L
F
R
D
I
S
W
R
Q
L
E
A
G
M
L
T
P
P
F
V
P
D
S
R
T
V
Y
A
K
N
----
G
A
F
S
------
G
V
A
F
E
---------
K
A
--------
D
T
E
F
F
Q
E
F
A
-
S
G
T
C
P
I
P
W
Q
E
E
M
I
E
T
G
V
-
F
G
D
L
N
V
W
R
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------
26
PsiBlast_CBE
64.36
34%
-93
- C1 -
3C50
1
RK_BOVIN
B:
[30-529]
---------------------------
S
R
D
R
---
K
YLA
R
----
L
K
L
P
P
L
S
K
C
E
A
--
L
R
E
S
L
D
----
L
G
F
E
G
M
C
L
-
E
Q
P
I
G
K
R
L
F
Q
Q
F
L
R
T
H
-
E
Q
H
G
P
----
A
----
L
Q
L
W
K
D
I
E
D
Y
D
T
A
D
-
D
A
L
R
P
Q
K
A
Q
A
L
---
R
A
A
Y
L
E
P
Q
A
Q
L
F
-
C
S
F
L
D
A
E
T
V
A
R
A
R
-
A
G
------
A
G
D
G
--
L
F
Q
P
L
L
R
A
V
L
A
H
L
G
Q
A
P
F
Q
E
F
L
D
S
L
Y
F
L
R
F
L
Q
W
K
W
L
E
A
Q
-
P
M
G
E
D
W
F
L
D
F
R
V
L
G
R
G
G
F
G
E
V
F
A
C
Q
M
---
K
---
A
---
T
G
K
L
Y
A
C
K
K
L
N
K
K
R
L
-
K
K
R
K
G
Y
-
Q
G
A
M
V
-
E
K
K
I
L
A
K
V
H
S
---
R
F
I
V
S
L
A
Y
A
F
E
T
K
T
D
L
C
L
V
M
T
I
M
N
G
G
D
I
R
---
Y
H
I
YNVD
E
D
N
P
----
G
--
F
Q
E
P
R
A
I
F
Y
T
A
Q
I
V
S
G
L
E
H
L
H
Q
-
R
N
I
I
Y
R
D
L
K
P
E
N
V
L
L
D
D
D
G
N
V
R
I
S
D
L
G
L
A
V
E
-
L
KA
G
---
Q
--
T
-
K
-
T
-
K
-
G
Y
A
--
G
T
P
G
F
M
A
P
E
-
L
L
L
-
G
E
E
Y
D
F
S
V
D
Y
F
A
L
G
V
T
L
Y
E
M
I
A
A
R
G
P
F
R
A
R
G
E
K
V
E
--
N
-
K
-
E
L
K
Q
R
V
L
E
Q
A
V
T
Y
P
D
K
F
S
P
A
S
K
D
F
C
E
A
L
L
Q
K
D
P
E
K
R
L
G
F
R
-
D
-
G
S
C
D
G
L
R
T
H
P
L
F
R
D
I
S
W
R
Q
L
E
A
G
M
L
T
P
P
F
V
P
D
S
R
T
V
Y
A
--------
F
S
T
--
V
K
-
G
V
A
F
E
---------
K
A
--------
D
T
E
F
F
Q
E
F
A
-
S
G
T
C
P
I
P
W
Q
E
E
M
I
E
T
G
V
-
F
G
D
L
N
V
W
R
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
64.36
38%
-100
- C1 -
4WNK
1
GRK5_BOVIN
A:
[60-526]
----------------------------------------------------------------------------
Q
P
V
G
R
L
L
F
R
Q
F
C
-----
E
T
R
P
G
L
E
S
Y
----
I
Q
F
L
D
S
V
A
E
Y
E
-
V
T
P
D
E
K
L
G
E
K
G
K
E
I
---
M
T
K
Y
L
T
P
K
S
-
P
V
-
F
I
T
Q
V
G
R
D
L
V
S
Q
T
-
E
E
K
L
L
Q
K
P
C
K
-
E
--
L
F
S
A
C
V
Q
S
V
H
D
Y
L
R
G
E
P
F
H
E
Y
L
D
S
M
Y
F
D
R
F
L
Q
W
K
W
L
E
R
Q
-
P
V
T
K
N
T
F
R
Q
Y
R
V
L
G
K
G
G
F
G
E
V
C
A
C
Q
V
---
R
---
A
---
T
G
K
M
Y
A
C
K
R
L
E
K
K
R
I
-
K
K
R
K
G
E
-
S
M
A
L
N
-
E
K
Q
I
L
E
K
V
N
S
R
---
F
V
V
N
L
A
Y
A
Y
E
T
K
D
A
L
C
L
V
L
T
I
M
N
G
G
D
L
K
---
F
H
I
----
Y
N
M
G
----
N
PG
F
E
E
E
R
A
L
F
Y
A
A
E
I
L
C
G
L
E
D
L
H
H
-
E
N
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
D
Y
G
H
I
R
I
S
D
L
G
L
A
V
K
-
I
--
P
---
E
--
G
-
D
L
I
-
R
-
G
R
V
--
G
T
V
G
Y
M
A
P
E
-
V
L
N
N
Q
-
R
Y
G
L
S
P
D
Y
W
G
L
G
C
L
I
Y
E
M
I
E
G
Q
S
P
F
R
G
R
K
E
K
-
V
--
K
R
E
-
E
V
D
R
R
V
L
E
T
E
E
V
Y
S
H
K
F
S
E
E
A
K
S
I
C
K
M
L
L
T
K
D
A
K
Q
R
L
G
C
Q
-
E
-
E
G
A
A
E
V
K
R
H
P
F
F
R
N
M
N
F
K
R
L
E
A
G
M
L
D
P
P
F
V
P
D
P
R
A
V
Y
-------------------------------
H
T
--------
D
D
D
F
Y
S
K
F
S
-
T
G
S
V
P
I
P
W
Q
S
E
M
I
E
T
E
C
-
F
K
E
L
N
V
F
G
P
H
G
T
L
S
P
D
L
N
R
S
H
-----------------------------------------------------------------------------------------------------------------------------------------------
28
PsiBlast_CBE
64.33
34%
-98
- C1 -
3C4X
1
RK_BOVIN
B:
[31-529]
----------------------------
R
D
R
---
K
Y
L
A
R
----
L
K
L
P
P
L
S
K
C
E
A
--
L
R
E
S
L
D
----
L
G
F
E
G
M
C
L
-
E
Q
P
I
G
K
R
L
F
Q
Q
F
L
R
T
H
-
E
Q
H
G
P
----
A
----
L
Q
L
W
K
D
I
E
D
Y
D
T
A
D
-
D
A
L
R
P
Q
K
A
Q
A
L
---
R
A
A
Y
L
E
P
Q
A
Q
L
F
-
C
S
F
L
D
A
E
T
V
A
R
A
-----------------
F
Q
P
L
L
R
A
V
L
A
H
L
G
Q
A
P
F
Q
E
F
L
D
S
L
Y
F
L
R
F
L
Q
W
K
W
L
E
A
Q
-
P
M
G
E
D
W
F
L
D
F
R
V
L
G
R
G
G
F
G
E
V
F
A
C
Q
M
---
K
---
A
---
T
G
K
L
Y
A
C
K
K
L
N
K
K
R
L
-
K
K
R
K
G
Y
-
Q
G
A
M
V
-
E
K
K
I
L
A
K
V
H
S
---
R
F
I
V
S
L
A
Y
A
F
E
T
K
T
D
L
C
L
V
M
T
I
M
N
G
G
D
I
R
---
Y
H
I
Y
NVD
E
D
N
P
----
G
--
F
Q
E
P
R
A
I
F
Y
T
A
Q
I
V
S
G
L
E
H
L
H
Q
-
R
N
I
I
Y
R
D
L
K
P
E
N
V
L
L
D
D
D
G
N
V
R
I
S
D
L
G
L
A
V
E
-
L
K
A
G
---
Q
--
T
-
K
-
T
-
K
-
G
Y
A
--
G
T
P
G
F
M
A
P
E
-
L
L
L
-
G
E
E
Y
D
F
S
V
D
Y
F
A
L
G
V
T
L
Y
E
M
I
A
A
R
G
P
F
R
A
R
G
E
K
V
E
--
N
-
K
-
E
L
K
Q
R
V
L
E
Q
A
V
T
Y
P
D
K
F
S
P
A
S
K
D
F
C
E
A
L
L
Q
K
D
P
E
K
R
L
G
F
R
-
D
-
G
S
C
D
G
L
R
T
H
P
L
F
R
D
I
S
W
R
Q
L
E
A
G
M
L
T
P
P
F
V
P
D
S
R
T
-----------------------
E
---------
K
A
--------
D
T
E
F
F
Q
E
F
A
-
S
G
T
C
P
I
P
W
Q
E
E
M
I
E
T
G
V
-
F
G
D
L
N
V
W
R
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------
96
HHSearch
64.30
35%
-93
- C1 -
3C4Z
1
RK_BOVIN
A:
[31-533]
----------------------------
R
D
R
K
Y
L
A
---
R
----
L
K
L
P
P
L
S
K
C
E
A
------
L
R
E
S
L
D
L
G
F
E
G
M
C
L
-
E
Q
P
I
G
K
R
L
F
Q
Q
F
L
R
T
H
-
E
Q
H
G
P
----
A
----
L
Q
L
W
K
D
I
E
D
Y
D
-
T
A
D
D
A
L
R
P
Q
K
A
Q
A
L
---
R
A
A
Y
L
E
P
Q
A
-
Q
L
-
F
C
S
F
L
D
A
E
T
V
A
R
A
-
R
A
-----
G
---
G
--
L
F
Q
P
L
L
R
A
V
L
A
H
L
G
Q
A
P
F
Q
E
F
L
D
S
L
Y
F
L
R
F
L
Q
W
K
W
L
E
A
Q
-
P
M
G
E
D
W
F
L
D
F
R
V
L
G
R
G
G
F
G
E
V
F
A
C
Q
M
---
K
---
A
---
T
G
K
L
Y
A
C
K
K
L
N
K
K
R
L
-
K
K
R
K
G
Y
-
Q
G
A
M
V
-
E
K
K
I
L
A
K
V
---
H
S
R
F
I
V
S
L
A
Y
A
F
E
T
K
T
D
L
C
L
V
M
T
I
M
N
G
G
D
I
R
---
Y
H
I
----
Y
N
V
D
ED
N
P
G
--
F
Q
E
P
R
A
I
F
Y
T
A
Q
I
V
S
G
L
E
H
L
H
Q
-
R
N
I
I
Y
R
D
L
K
P
E
N
V
L
L
D
D
D
G
N
V
R
I
S
D
L
G
L
A
V
E
-
L
--
K
---
A
GQ
T
-
K
-
T
-
K
-
G
Y
A
--
G
T
P
G
F
M
A
P
E
-
L
L
L
-
G
E
E
Y
D
F
S
V
D
Y
F
A
L
G
V
T
L
Y
E
M
I
A
A
R
G
P
F
R
A
R
G
E
K
V
E
--
N
-
K
-
E
L
K
Q
R
V
L
E
Q
A
V
T
Y
P
D
K
F
S
P
A
S
K
D
F
C
E
A
L
L
Q
K
D
P
E
K
R
L
G
F
R
-
D
-
G
S
C
D
G
L
R
T
H
P
L
F
R
D
I
S
W
R
Q
L
E
A
G
M
L
T
P
P
F
V
P
D
S
R
T
V
Y
A
K
N
----
G
A
F
S
------
G
V
A
F
E
---------
K
A
--------
D
T
E
F
F
Q
E
F
A
-
S
G
T
C
P
I
P
W
Q
E
E
M
I
E
T
G
V
-
F
G
D
L
N
V
W
R
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------
29
PsiBlast_CBE
63.96
34%
-94
- C1 -
3C4X
1
RK_BOVIN
A:
[30-529]
---------------------------
S
R
D
R
---
K
Y
L
A
R
----
L
K
L
P
P
L
S
K
C
E
A
--
L
R
E
S
L
D
----
L
G
F
E
G
M
C
L
-
E
Q
P
I
G
K
R
L
F
Q
Q
F
L
R
T
H
-
E
Q
H
G
P
----
A
----
L
Q
L
W
K
D
I
E
D
Y
D
T
A
D
-
D
A
L
R
P
Q
K
A
Q
A
L
---
R
A
A
Y
L
E
P
Q
A
Q
L
F
-
C
S
F
L
D
A
E
T
V
A
R
A
R
-
A
G
------
A
G
D
G
--
L
F
Q
P
L
L
R
A
V
L
A
H
L
G
Q
A
P
F
Q
E
F
L
D
S
L
Y
F
L
R
F
L
Q
W
K
W
L
E
A
Q
-
P
M
G
E
D
W
F
L
D
F
R
V
L
G
R
G
G
F
G
E
V
F
A
C
Q
M
---
K
---
A
---
T
G
K
L
Y
A
C
K
K
L
N
K
K
R
L
-
K
K
R
K
G
Y
-
Q
G
A
M
V
-
E
K
K
I
L
A
K
V
H
S
---
R
F
I
V
S
L
A
Y
A
F
E
T
K
T
D
L
C
L
V
M
T
I
M
N
G
G
D
I
R
---
Y
H
I
Y
N
VD
E
D
N
P
----
G
--
F
Q
E
P
R
A
I
F
Y
T
A
Q
I
V
S
G
L
E
H
L
H
Q
-
R
N
I
I
Y
R
D
L
K
P
E
N
V
L
L
D
D
D
G
N
V
R
I
S
D
L
G
L
A
V
E
-
L
K
A
G
---
Q
--
T
-
K
-
T
-
K
-
G
Y
A
--
G
T
P
G
F
M
A
P
E
-
L
L
L
-
G
E
E
Y
D
F
S
V
D
Y
F
A
L
G
V
T
L
Y
E
M
I
A
A
R
G
P
F
R
A
R
G
E
K
V
E
--
N
-
K
-
E
L
K
Q
R
V
L
E
Q
A
V
T
Y
P
D
K
F
S
P
A
S
K
D
F
C
E
A
L
L
Q
K
D
P
E
K
R
L
G
F
R
-
D
-
G
S
C
D
G
L
R
T
H
P
L
F
R
D
I
S
W
R
Q
L
E
A
G
M
L
T
P
P
F
V
P
D
--------
I
Q
D
V
G
A
F
S
T
--
V
K
-
G
V
A
F
E
---------
K
A
--------
D
T
E
F
F
Q
E
F
A
-
S
G
T
C
P
I
P
W
Q
E
E
M
I
E
T
G
V
-
F
G
D
L
N
V
W
R
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
63.95
38%
-95
- C1 -
4TND
1
GRK5_HUMAN
A:
[60-526]
----------------------------------------------------------------------------
Q
P
I
G
R
L
L
F
R
Q
F
C
-----
E
T
R
P
G
L
E
C
Y
----
I
Q
F
L
D
S
V
A
E
Y
E
-
V
T
P
D
E
K
L
G
E
K
G
K
K
I
---
M
T
K
Y
L
T
P
K
S
-
P
V
-
F
I
A
Q
V
G
Q
D
L
V
S
Q
T
-
E
E
K
L
L
Q
K
P
C
K
-
E
--
L
F
S
A
C
A
Q
S
V
H
E
Y
L
R
G
E
P
F
H
E
Y
L
D
S
M
F
F
D
R
F
L
Q
W
K
W
L
E
R
Q
-
P
V
T
K
N
T
F
R
Q
Y
R
V
L
G
K
G
G
F
G
E
V
C
A
C
Q
V
---
R
---
A
---
T
G
K
M
Y
A
C
K
R
L
E
K
K
R
I
-
K
K
R
K
G
E
-
S
M
A
L
N
-
E
K
Q
I
L
E
K
V
N
S
---
Q
F
V
V
N
L
A
Y
A
Y
E
T
K
D
A
L
C
L
V
L
T
I
M
N
G
G
D
L
K
---
F
H
I
----
Y
N
M
G
----
N
PG
F
E
E
E
R
A
L
F
Y
A
A
E
I
L
C
G
L
E
D
L
H
H
-
E
N
T
V
Y
R
D
L
K
P
E
N
I
L
L
D
D
Y
G
H
I
R
I
S
D
L
G
L
A
V
K
-
I
--
P
---
E
--
G
-
D
L
I
-
R
-
G
R
V
--
G
T
V
G
Y
M
A
P
E
-
V
L
N
N
Q
-
R
Y
G
L
S
P
D
Y
W
G
L
G
C
L
I
Y
E
M
I
E
G
Q
S
P
F
R
G
R
K
E
K
-
V
--
K
R
E
-
E
V
D
R
R
V
L
E
T
E
E
V
Y
S
H
K
F
S
E
E
A
K
S
I
C
K
M
L
L
T
K
D
A
K
Q
R
L
G
C
Q
-
E
-
E
E
A
A
E
V
K
R
H
P
F
F
R
N
M
N
F
K
R
L
E
A
G
M
L
D
P
P
F
V
P
D
P
R
A
V
Y
C
K
D
V
L
D
I
E
Q
F
S
--
T
V
K
-
G
V
N
L
D
---------
H
T
--------
D
D
D
F
Y
S
K
F
S
-
T
G
S
V
S
I
P
W
Q
N
E
M
I
E
T
E
C
-
F
K
E
L
N
V
F
G
P
N
G
T
L
P
P
D
L
N
R
N
H
P
P
---------------------------------------------------------------------------------------------------------------------------------------------
97
HHSearch
63.83
39%
-95
- C1 -
2ACX
1
GRK6_HUMAN
A:
[14-526]
--------------
K
A
R
---------
K
G
K
-
S
---
K
---
K
W
R
Q
M
L
Q
F
P
H
I
S
Q
C
------
E
E
L
R
L
S
L
E
R
D
Y
H
S
L
C
E
-
R
N
P
I
G
R
L
L
F
R
E
F
C
A
T
R
-
P
E
L
S
R
----
C
----
V
A
F
L
D
G
V
A
E
Y
E
V
T
P
-
D
D
K
R
K
A
C
G
R
N
L
---
T
Q
N
F
L
S
H
T
G
-
P
D
-
L
I
P
E
V
P
R
Q
L
V
T
N
C
-
T
Q
R
L
E
-
Q
G
P
C
K
D
--
L
F
Q
E
L
T
R
L
T
H
E
Y
L
S
V
A
P
F
A
D
Y
L
D
S
I
Y
F
N
R
F
L
Q
W
K
W
L
E
R
Q
-
P
V
T
K
N
T
F
R
Q
Y
R
V
L
G
K
G
G
F
G
E
V
C
A
C
Q
V
---
R
---
A
---
T
G
K
M
Y
A
C
K
K
L
E
K
K
R
I
-
K
K
R
K
G
E
-
A
M
A
L
N
-
E
K
Q
I
L
E
K
V
---
N
S
R
F
V
V
S
L
A
Y
A
Y
E
T
K
D
A
L
C
L
V
L
T
L
M
N
G
G
D
L
K
---
F
H
I
----
Y
H
M
G
Q
A
--
G
--
F
P
E
A
R
A
V
F
Y
A
A
E
I
C
C
G
L
E
D
L
H
R
-
E
R
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
D
H
G
H
I
R
I
S
D
L
G
L
A
V
H
-
V
--
P
---
E
--
G
Q
T
-
I
-
K
-
G
R
V
--
G
T
V
G
Y
M
A
P
E
-
V
V
K
-
N
E
R
Y
T
F
S
P
D
W
W
A
L
G
C
L
L
Y
E
M
I
A
G
Q
S
P
F
Q
Q
R
K
K
K
I
K
--
R
-
E
-
E
V
E
R
L
V
K
E
V
P
E
E
Y
S
E
R
F
S
P
Q
A
R
S
L
C
S
Q
L
L
C
K
D
P
A
E
R
L
G
C
R
-
G
-
G
S
A
R
E
V
K
E
H
P
L
F
K
K
L
N
F
K
R
L
G
A
G
M
L
E
P
P
F
K
P
D
P
Q
A
I
Y
C
--------------------
E
---------
P
T
--------
D
Q
D
F
Y
Q
K
F
A
-
T
G
S
V
P
I
P
W
Q
N
E
M
V
E
T
-
E
C
F
Q
E
L
N
V
F
G
L
D
G
S
--------------------------------------------------------------------------------------------------------------------------------------------------------
25
PsiBlast_CBE
63.55
34%
-94
- C1 -
3C51
1
RK_BOVIN
A:
[31-529]
----------------------------
R
D
R
---
K
Y
L
A
R
----
L
K
L
P
P
L
S
K
C
E
A
--
L
R
E
S
L
D
----
L
G
F
E
G
M
C
L
-
E
Q
P
I
G
K
R
L
F
Q
Q
F
L
R
T
H
-
E
Q
H
G
P
----
A
----
L
Q
L
W
K
D
I
E
D
Y
D
T
A
D
-
D
A
L
R
P
Q
K
A
Q
A
L
---
R
A
A
Y
L
E
P
Q
A
Q
L
F
-
C
S
F
L
D
A
E
T
V
A
R
A
R
-
A
G
---------
G
--
L
F
Q
P
L
L
R
A
V
L
A
H
L
G
Q
A
P
F
Q
E
F
L
D
S
L
Y
F
L
R
F
L
Q
W
K
W
L
E
A
Q
-
P
M
G
E
D
W
F
L
D
F
R
V
L
G
R
G
G
F
G
E
V
F
A
C
Q
M
---
K
---
A
---
T
G
K
L
Y
A
C
K
K
L
N
K
K
R
L
-
K
K
R
K
G
Y
-
Q
G
A
M
V
-
E
K
K
I
L
A
K
V
H
S
---
R
F
I
V
S
L
A
Y
A
F
E
T
K
T
D
L
C
L
V
M
T
I
M
N
G
G
D
I
R
---
Y
H
I
YNVD
E
D
N
P
----
G
--
F
Q
E
P
R
A
I
F
Y
T
A
Q
I
V
S
G
L
E
H
L
H
Q
-
R
N
I
I
Y
R
D
L
K
P
E
N
V
L
L
D
D
D
G
N
V
R
I
S
D
L
G
L
A
V
E
-
L
K
A
G
---
Q
--
T
-
K
-
T
-
K
-
G
Y
A
--
G
T
P
G
F
M
A
P
E
-
L
L
L
-
G
E
E
Y
D
F
S
V
D
Y
F
A
L
G
V
T
L
Y
E
M
I
A
A
R
G
P
F
R
A
R
G
E
K
V
E
--
N
-
K
-
E
L
K
Q
R
V
L
E
Q
A
V
T
Y
P
D
K
F
S
P
A
S
K
D
F
C
E
A
L
L
Q
K
D
P
E
K
R
L
G
F
R
-
D
-
G
S
C
D
G
L
R
T
H
P
L
F
R
D
I
S
W
R
Q
L
E
A
G
M
L
T
P
P
F
V
P
D
S
R
-------------
S
T
--
V
K
-
G
V
A
F
E
---------
K
A
--------
D
T
E
F
F
Q
E
F
A
-
S
G
T
C
P
I
P
W
Q
E
E
M
I
E
T
G
V
-
F
G
D
L
N
V
W
R
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------
86
Fugue
63.50
34%
-86
- C1 -
3C4Z
1
RK_BOVIN
A:
[31-533]
-------------------------
R
D
R
K
Y
L
---
A
---
R
----
L
K
L
P
P
----
L
S
--
K
C
E
A
L
R
E
S
L
D
L
G
F
E
G
M
-
C
L
E
Q
P
I
G
K
R
L
F
Q
Q
F
L
R
T
H
-
E
Q
H
G
P
----
A
----
L
Q
L
W
K
D
I
E
D
Y
D
-
T
A
D
D
A
L
R
P
Q
K
A
Q
A
L
---
R
A
A
Y
L
E
P
Q
----------
A
Q
L
F
C
S
F
L
-
D
A
E
T
V
A
R
A
R
A
G
G
--
L
F
Q
P
L
L
R
A
V
L
A
H
L
G
Q
A
P
F
Q
E
F
L
D
S
L
Y
F
L
R
F
L
Q
W
K
W
L
E
A
Q
-
P
M
G
E
D
W
F
L
D
F
R
V
L
G
R
G
G
F
G
E
V
F
A
C
Q
M
---
K
---
A
---
T
G
K
L
Y
A
C
K
K
L
N
K
K
R
L
-
K
K
R
K
G
Y
-
Q
G
A
M
V
-
E
K
K
I
L
A
K
V
H
S
---
R
F
I
V
S
L
A
Y
A
F
E
T
K
T
D
L
C
L
V
M
T
I
M
N
G
G
D
I
R
---
Y
H
I
YNVD
E
D
N
P
----
G
--
F
Q
E
P
R
A
I
F
Y
T
A
Q
I
V
S
G
L
E
H
L
H
Q
-
R
N
I
I
Y
R
D
L
K
P
E
N
V
L
L
D
D
D
G
N
V
R
I
S
D
L
G
L
A
V
E
-
L
--
K
AG-
Q
--
T
-
K
-
T
-
K
-
G
Y
A
--
G
T
P
G
F
M
A
P
E
-
L
L
-
L
G
E
E
Y
D
F
S
V
D
Y
F
A
L
G
V
T
L
Y
E
M
I
A
A
R
G
P
F
R
A
R
G
E
K
V
E
--
N
-
K
-
E
L
K
Q
R
V
L
E
Q
A
V
T
Y
P
D
K
F
S
P
A
S
K
D
F
C
E
A
L
L
Q
K
D
P
E
K
R
L
G
F
R
-
D
-
G
S
C
D
G
L
R
T
H
P
L
F
R
D
I
S
W
R
Q
L
E
A
G
M
L
T
P
P
F
V
P
D
S
R
T
V
Y
A
K
N
---------
G
A
F
S
-
G
V
A
F
E
---------
K
A
--------
D
T
E
F
F
Q
E
F
A
-
S
G
T
C
P
I
P
W
Q
E
E
M
I
E
T
G
V
-
F
G
D
L
N
V
W
R
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
62.93
36%
-83
- C1 -
4YHJ
1
?
A:
[25-525]
---------------------------
G
R
S
K
---
K
W
K
E
I
----
L
T
L
P
P
V
S
Q
C
S
E
--
L
R
H
S
I
E
K
D
Y
S
S
L
C
D
K
-----
Q
P
I
G
R
R
L
F
R
Q
F
C
-----
D
T
K
P
----
T
L
K
R
H
I
E
F
L
D
A
V
A
E
Y
E
-
V
A
D
D
E
D
R
S
D
C
G
L
S
I
---
L
D
R
F
F
N
D
K
L
-
A
A
----
P
L
P
E
I
P
P
D
V
V
T
E
C
R
L
G
L
K
E
E
N
P
S
KK
A
F
E
E
C
T
R
V
A
H
N
Y
L
R
G
E
P
F
E
E
Y
Q
E
S
S
Y
F
S
Q
F
L
Q
W
K
W
L
E
R
Q
-
P
V
T
K
N
T
F
R
H
Y
R
V
L
G
K
G
G
F
G
E
V
C
A
C
Q
V
---
R
---
A
---
T
G
K
M
Y
A
C
K
K
L
Q
K
K
R
I
-
K
K
R
K
G
E
-
A
M
A
L
N
-
E
K
R
I
L
E
K
V
Q
S
R
---
F
V
V
S
L
A
Y
A
Y
E
T
K
D
A
L
C
L
V
L
T
I
M
N
G
G
D
L
K
---
F
H
I
----
Y
N
L
G
----
N
PG
F
D
E
Q
R
A
V
F
Y
A
A
E
L
C
C
G
L
E
D
L
Q
R
-
E
R
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
D
R
G
H
I
R
I
S
D
L
G
L
A
T
E
-
I
--
P
---
E
G-
Q
-
R
-
V
-
R
-
G
R
V
--
G
T
V
G
Y
M
A
P
E
-
V
V
N
N
E
-
K
Y
T
F
S
P
D
W
W
G
L
G
C
L
I
Y
E
M
I
Q
G
H
S
P
F
K
K
Y
K
E
K
-
V
--
K
W
E
-
E
V
D
Q
R
I
K
N
D
T
E
E
Y
S
E
K
F
S
E
D
A
K
S
I
C
R
M
L
L
T
K
N
P
S
K
R
L
G
C
R
-
G
-
E
G
A
A
G
V
K
Q
H
P
V
F
K
D
I
N
F
R
R
L
E
A
N
M
L
E
P
P
F
C
P
D
P
H
A
V
Y
C
K
D
V
L
D
I
E
Q
F
S
V
--
V
K
-
G
I
Y
L
D
---------
T
A
--------
D
E
D
F
Y
A
R
F
A
-
T
G
C
V
S
I
P
W
Q
N
E
M
I
E
S
G
C
-
F
K
D
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------
24
PsiBlast_CBE
62.83
36%
-83
- C1 -
4YHJ
1
?
B:
[25-526]
---------------------------
G
R
S
K
---
K
WKE
I
----
L
T
L
P
P
V
S
Q
C
S
E
--
L
R
H
S
I
E
K
D
Y
S
S
L
C
D
K
-----
Q
P
I
G
R
R
L
F
R
Q
F
C
-----
D
T
K
P
----
T
LKRH
I
E
F
L
D
A
V
A
E
Y
E
-
V
A
D
D
E
D
R
S
D
C
G
L
S
I
---
L
D
R
F
F
N
D
K
L
-
A
A
----
P
L
P
E
I
P
P
D
V
V
T
E
C
R
L
G
L
K
E
E
N
P
S
KK
A
F
E
E
C
T
R
V
A
H
N
Y
L
R
G
E
P
F
E
E
Y
Q
E
S
S
Y
F
S
Q
F
L
Q
W
K
W
L
E
R
Q
-
P
V
T
K
N
T
F
R
H
Y
R
V
L
G
K
G
G
F
G
E
V
C
A
C
Q
V
---
R
---
A
---
T
G
K
M
Y
A
C
K
K
L
Q
K
K
R
I
-
K
K
R
K
G
E
-
A
M
A
L
N
-
E
K
R
I
L
E
K
V
Q
S
R
---
F
V
V
S
L
A
Y
A
Y
E
T
K
D
A
L
C
L
V
L
T
I
M
N
G
G
D
L
K
---
F
H
I
----
Y
N
L
G
----
N
PG
F
D
E
Q
R
A
V
F
Y
A
A
E
L
C
C
G
L
E
D
L
Q
R
-
E
R
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
D
R
G
H
I
R
I
S
D
L
G
L
A
T
E
-
I
--
P
---
E
G-
Q
-
R
-
V
-
R
-
G
R
V
--
G
T
V
G
Y
M
A
P
E
-
V
V
N
N
E
-
K
Y
T
F
S
P
D
W
W
G
L
G
C
L
I
Y
E
M
I
Q
G
H
S
P
F
K
K
Y
K
E
K
-
V
--
K
W
E
-
E
V
D
Q
R
I
K
N
D
T
E
E
Y
S
E
K
F
S
E
D
A
K
S
I
C
R
M
L
L
T
K
N
P
S
K
R
L
G
C
R
-
G
-
E
G
A
A
G
V
K
Q
H
P
V
F
K
D
I
N
F
R
R
L
E
A
N
M
L
E
P
P
F
C
P
D
P
H
A
V
Y
C
----------------
G
I
Y
L
D
---------
T
A
--------
D
E
D
F
Y
A
R
F
A
-
T
G
C
V
S
I
P
W
Q
N
E
M
I
E
S
G
C
-
F
K
D
I
N
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------
39
PsiBlast_CBE
62.36
35%
-98
- C1 -
4L9I
2
RK_BOVIN
A:
[26-500]
-----------------------------------------------------------------
D
L
G
F
E
G
M
C
L
-
E
Q
P
I
G
K
R
L
F
Q
Q
F
L
R
T
H
-
E
Q
H
G
P
----
A
----
L
Q
L
W
K
D
I
E
D
Y
D
T
A
D
-
D
A
L
R
P
Q
K
A
Q
A
L
---
R
A
A
Y
L
E
P
Q
A
Q
L
F
-
C
S
F
L
D
A
E
T
V
A
R
A
R
-
A
G
------
A
G
D
G
--
L
F
Q
P
L
L
R
A
V
L
A
H
L
G
Q
A
P
F
Q
E
F
L
D
S
L
Y
F
L
R
F
L
Q
W
K
W
L
E
A
Q
-
P
M
G
E
D
W
F
L
D
F
R
V
L
G
R
G
G
F
G
E
V
F
A
C
Q
M
---
K
---
A
---
T
G
K
L
Y
A
C
K
K
L
N
K
K
R
L
-
K
K
R
K
G
Y
-
Q
G
A
M
V
-
E
K
K
I
L
A
K
V
H
S
---
R
F
I
V
S
L
A
Y
A
F
E
T
K
T
D
L
C
L
V
M
T
I
M
N
G
G
D
I
R
---
Y
H
I
YNVD
E
D
N
P
----
G
--
F
Q
E
P
R
A
I
F
Y
T
A
Q
I
V
S
G
L
E
H
L
H
Q
-
R
N
I
I
Y
R
D
L
K
P
E
N
V
L
L
D
D
D
G
N
V
R
I
S
D
L
G
L
A
V
E
-
L
K
A
G
---
Q
--
T
-
K
-
T
-
K
-
G
Y
A
--
G
T
P
G
F
M
A
P
E
-
L
L
L
-
G
E
E
Y
D
F
S
V
D
Y
F
A
L
G
V
T
L
Y
E
M
I
A
A
R
G
P
F
R
A
R
G
E
K
V
E
--
N
-
K
-
E
L
K
Q
R
V
L
E
Q
A
V
T
Y
P
D
K
F
S
P
A
S
K
D
F
C
E
A
L
L
Q
K
D
P
E
K
R
L
G
F
R
-
D
-
G
S
C
D
G
L
R
T
H
P
L
F
R
D
I
S
W
R
Q
L
E
A
G
M
L
T
P
P
F
V
P
D
S
R
T
V
Y
A
K
N
I
Q
D
V
G
A
F
S
T
--
V
K
-
G
V
A
F
E
---------
K
A
--------
D
T
E
F
F
Q
E
F
A
-
S
G
T
C
P
I
P
W
Q
E
E
M
I
E
T
G
V
-
F
G
D
L
N
V
W
R
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
62.10
38%
-93
- C1 -
4TNB
1
GRK5_HUMAN
A:
[60-526]
----------------------------------------------------------------------------
Q
P
I
G
R
L
L
F
R
Q
F
C
-----
E
T
R
P
G
L
E
C
Y
----
I
Q
F
L
D
S
V
A
E
Y
E
-
V
T
P
D
E
K
L
G
E
K
G
K
K
I
---
M
T
K
Y
L
T
P
K
S
-
P
V
-
F
I
A
Q
V
G
Q
D
L
V
S
Q
T
-
E
E
K
L
L
Q
K
P
C
K
-
E
--
L
F
S
A
C
A
Q
S
V
H
E
Y
L
R
G
E
P
F
H
E
Y
L
D
S
M
F
F
D
R
F
L
Q
W
K
W
L
E
R
Q
-
P
V
T
K
N
T
F
R
Q
Y
R
V
L
G
K
G
G
F
G
E
V
C
A
C
Q
V
---
R
---
A
---
T
G
K
M
Y
A
C
K
R
L
E
K
K
R
I
-
K
K
R
K
G
E
-
S
M
A
L
N
-
E
K
Q
I
L
E
K
V
N
S
---
Q
F
V
V
N
L
A
Y
A
Y
E
T
K
D
A
L
C
L
V
L
T
I
M
N
G
G
D
L
K
---
F
H
I
----
Y
N
M
G
----
N
PG
F
E
E
E
R
A
L
F
Y
A
A
E
I
L
C
G
L
E
D
L
H
H
-
E
N
T
V
Y
R
D
L
K
P
E
N
I
L
L
D
D
Y
G
H
I
R
I
S
D
L
G
L
A
V
K
-
I
--
P
---
E
--
G
-
D
L
I
-
R
-
G
R
V
--
G
T
V
G
Y
M
A
P
E
-
V
L
N
N
Q
-
R
Y
G
L
S
P
D
Y
W
G
L
G
C
L
I
Y
E
M
I
E
G
Q
S
P
F
R
G
R
K
E
K
-
V
--
K
R
E
-
E
V
D
R
R
V
L
E
T
E
E
V
Y
S
H
K
F
S
E
E
A
K
S
I
C
K
M
L
L
T
K
D
A
K
Q
R
L
G
C
Q
-
E
-
E
E
A
A
E
V
K
R
H
P
F
F
R
N
M
N
F
K
R
L
E
A
G
M
L
D
P
P
F
V
P
D
P
R
A
V
Y
C
K
D
V
L
D
I
E
Q
F
S
--
T
V
K
-
G
V
N
L
D
---------
H
T
--------
D
D
D
F
Y
S
K
F
S
-
T
G
S
V
S
I
P
W
Q
N
E
M
I
E
T
E
C
-
F
K
E
L
N
V
F
G
P
N
G
T
L
P
P
D
L
N
R
N
H
P
P
---------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
60.88
38%
-88
- C1 -
2ACX
1
GRK6_HUMAN
A:
[14-526]
--------------
K
A
R
---------
K
G
K
S
K
---
K
W
--
R
----
Q
M
L
Q
F
P
H
I
S
Q
C
E
E
L
R
L
S
L
E
R
D
Y
H
S
L
C
E
R
-----
N
P
I
G
R
L
L
F
R
E
F
C
A
T
R
P
E
L
S
R
-----
C
----
V
A
F
L
D
G
V
A
E
Y
E
-
V
T
P
D
D
K
R
K
A
C
G
R
N
L
T
Q
N
F
L
S
H
T
G
P
D
L
-
I
P
E
V
P
R
Q
L
V
T
N
C
T
Q
R
L
-
E
Q
G
P
C
K
-----
D
--
L
F
Q
E
L
T
R
L
T
H
E
Y
L
S
V
A
P
F
A
D
Y
L
D
S
I
Y
F
N
R
F
L
Q
W
K
W
L
E
R
Q
-
P
V
T
K
N
T
F
R
Q
Y
R
V
L
G
K
G
G
F
G
E
V
C
A
C
Q
V
---
R
---
A
---
T
G
K
M
Y
A
C
K
K
L
E
K
K
R
I
-
K
K
R
K
G
E
-
A
M
A
L
N
-
E
K
Q
I
L
E
K
V
N
S
R
---
F
V
V
S
L
A
Y
A
Y
E
T
K
D
A
L
C
L
V
L
T
L
M
N
G
G
D
L
K
F
H
I
Y
H
M
----
G
Q
A
G
-------
F
P
E
A
R
A
V
F
Y
A
A
E
I
C
C
G
L
E
D
L
H
R
-
E
R
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
D
H
G
H
I
R
I
S
D
L
G
L
A
V
H
-
V
--
P
---
E
--
G
-
Q
-
T
I
K
-
G
R
V
--
G
T
V
G
Y
M
A
P
E
-
V
V
-
K
N
E
R
Y
T
F
S
P
D
W
W
A
L
G
C
L
L
Y
E
M
I
A
G
Q
S
P
F
Q
Q
R
K
K
K
-
I
--
K
-
R
E
E
V
E
R
L
V
K
E
V
P
E
E
Y
S
E
R
F
S
P
Q
A
R
S
L
C
S
Q
L
L
C
K
D
P
A
E
R
L
G
C
R
-
G
-
G
S
A
R
E
V
K
E
H
P
L
F
K
K
L
N
F
K
R
L
G
A
G
M
L
E
P
P
F
K
P
D
P
Q
A
I
Y
C
--------------------
E
---------
P
T
--------
D
Q
D
F
Y
Q
K
F
A
-
T
G
S
V
P
I
P
W
Q
N
E
M
V
E
T
E
C
-
F
Q
E
L
N
V
F
G
L
D
G
S
--------------------------------------------------------------------------------------------------------------------------------------------------------
23
PsiBlast_CBE
60.64
38%
-89
- C1 -
2ACX
1
GRK6_HUMAN
B:
[14-526]
--------------
K
A
R
---------
K
G
K
S
K
---
K
W
--
R
----
Q
M
L
Q
F
P
H
I
S
Q
C
E
E
L
R
L
S
L
E
R
D
Y
H
S
L
C
E
R
-----
N
P
I
G
R
L
L
F
R
E
F
C
A
T
R
P
E
L
S
R
-----
C
----
V
A
F
L
D
G
V
A
E
Y
E
-
V
T
P
D
D
K
R
K
A
C
G
R
N
L
T
Q
N
F
L
S
H
T
G
P
D
L
-
I
P
E
V
P
R
Q
L
V
T
N
C
T
Q
R
L
-
E
Q
G
P
C
K
-----
D
--
L
F
Q
E
L
T
R
L
T
H
E
Y
L
S
V
A
P
F
A
D
Y
L
D
S
I
Y
F
N
R
F
L
Q
W
K
W
L
E
R
Q
-
P
V
T
K
N
T
F
R
Q
Y
R
V
L
G
K
G
G
F
G
E
V
C
A
C
Q
V
---
R
---
A
---
T
G
K
M
Y
A
C
K
K
L
E
K
K
R
I
-
K
K
R
K
G
E
-
A
M
A
L
N
-
E
K
Q
I
L
E
K
V
N
S
R
---
F
V
V
S
L
A
Y
A
Y
E
T
K
D
A
L
C
L
V
L
T
L
M
N
G
G
D
L
K
F
H
I
Y
H
M
------
A
G
-------
F
P
E
A
R
A
V
F
Y
A
A
E
I
C
C
G
L
E
D
L
H
R
-
E
R
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
D
H
G
H
I
R
I
S
D
L
G
L
A
V
H
-
V
--
P
---
E
--
G
-
Q
-
T
I
K
-
G
R
V
--
G
T
V
G
Y
M
A
P
E
-
V
V
-
K
N
E
R
Y
T
F
S
P
D
W
W
A
L
G
C
L
L
Y
E
M
I
A
G
Q
S
P
F
Q
Q
---
K
-
I
--
K
-
R
E
E
V
E
R
L
V
K
E
V
P
E
E
Y
S
E
R
F
S
P
Q
A
R
S
L
C
S
Q
L
L
C
K
D
P
A
E
R
L
G
C
R
-
G
-
G
S
A
R
E
V
K
E
H
P
L
F
K
K
L
N
F
K
R
L
G
A
G
M
L
E
P
P
F
K
P
D
P
Q
A
I
Y
---------------------
E
---------
P
T
--------
D
Q
D
F
Y
Q
K
F
A
-
T
G
S
V
P
I
P
W
Q
N
E
M
V
E
T
E
C
-
F
Q
E
L
N
V
F
G
L
D
G
S
V
P
P
-----------------------------------------------------------------------------------------------------------------------------------------------------
108
HHSearch
52.20
33%
-98
- C1 -
4DC2
1
KPCI_MOUSE
A:
[49-384]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
L
Q
D
F
D
L
L
R
V
I
G
R
G
S
Y
A
K
V
L
L
V
R
L
---
K
---
K
---
T
D
R
I
Y
A
M
R
V
V
K
K
E
L
V
-
N
----
I
-
D
W
V
Q
T
-
E
K
H
V
F
E
Q
A
--
S
N
H
P
F
L
V
G
L
H
S
C
F
Q
T
E
S
R
L
F
F
V
I
E
Y
V
N
G
G
D
L
M
---
F
H
M
----
Q
R
Q
R
----
K
--
L
P
E
E
H
A
R
F
Y
S
A
E
I
S
L
A
L
N
Y
L
H
E
-
R
G
I
I
Y
R
D
L
K
L
D
N
V
L
L
D
S
E
G
H
I
K
L
T
D
Y
G
M
C
K
E
-
G
--
L
---
R
PG
D
-
T
-
T
-
S
-
T
F
C
--
G
T
P
N
Y
I
A
P
E
-
I
L
R
-
G
E
D
Y
G
F
S
V
D
W
W
A
L
G
V
L
M
F
E
M
M
A
G
R
S
P
F
D
I
V
G
S
---NT
E
-
D
-
Y
L
F
Q
V
I
L
E
K
Q
I
R
I
P
R
S
L
S
V
K
A
A
S
V
L
K
S
F
L
N
K
D
P
K
E
R
L
G
C
H
P
Q
-
T
G
F
A
D
I
Q
G
H
P
F
F
R
N
V
D
W
D
M
M
E
Q
K
Q
V
V
P
P
F
K
P
N
I
-----
S
G
E
F
G
L
D
N
F
D
S
Q
F
T
N
E
P
V
Q
L
T
---------
P
D
D
D
D
I
V
R
KI
D
Q
S
E
F
E
G
F
E
-
Y
-
I
N
P
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
99
HHSearch
51.86
38%
-98
- C1 -
4GV1
5
AKT1_HUMAN
A:
[4-304]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
V
T
M
N
E
F
E
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
K
E
---
K
---
A
---
T
G
R
Y
Y
A
M
K
I
L
K
K
E
V
I
-
V
A
K
D
E
V
-
A
H
T
L
T
-
E
N
R
V
L
Q
N
S
---
R
H
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
---
F
H
L
----
S
R
E
R
----
V
--
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
K
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
K
D
G
H
I
K
I
T
D
F
G
L
C
K
E
-
G
--
I
---
K
DG
A
-
T
-
M
-
K
-
T
F
C
--
G
T
P
E
Y
L
A
P
E
-
V
L
E
-
D
N
D
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
Y
N
Q
----
D
--
H
-
E
-
K
L
F
E
L
I
L
M
E
E
I
R
F
P
R
T
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
R
L
G
G
G
-
S
-
E
D
A
K
E
I
M
Q
H
R
F
F
A
G
I
V
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
P
Q
V
-----
T
S
E
T
D
T
R
Y
F
D
E
E
F
T
A
-
Q
M
I
T
I
---------
T
P
--------
S
M
E
C
V
D
S
E
R
-
R
-
P
H
F
P
Q
F
D
Y
S
A
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------
113
HHSearch
51.03
38%
-102
- C1 -
4EJN
3
AKT1_HUMAN
A:
[144-438]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
V
T
M
N
E
F
E
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
K
E
---
K
---
A
---
T
G
R
Y
Y
A
M
K
I
L
K
K
E
V
I
-
V
---------------
V
L
Q
N
---
S
R
H
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
---
F
H
L
----
S
R
E
R
----
V
--
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
K
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
K
D
G
H
I
K
I
T
D
F
G
L
C
K
E
-
G
--
I
---
K
--------
K
-
T
F
C
--
G
T
P
E
Y
L
A
P
E
-
V
L
E
-
D
N
D
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
Y
N
---
Q
-
D
--
H
-
E
-
K
L
F
E
L
I
L
M
E
E
I
R
F
P
R
T
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
R
L
G
G
G
-
S
-
E
D
A
K
E
I
M
Q
H
R
F
F
A
G
I
V
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
P
Q
V
-----
T
S
E
T
D
T
R
Y
F
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
42
PsiBlast_CBE
49.92
37%
-95
- C1 -
4NW5
1
KS6A3_HUMAN
A:
[30-322]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
Q
F
E
L
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
V
K
K
ISG
S
---
D
---
A
R
Q
L
Y
A
M
K
V
L
K
K
A
T
L
-
K
V
R
D
R
V
-
R
T
K
M
E
-
R
D
I
L
V
E
V
----
N
H
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
---
T
R
L
----
S
K
E
V
----
M
--
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
S
-
L
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
G
H
I
K
L
T
D
F
G
L
S
K
E
-
S
ID
H
---
E
--
K
-
K
-
A
-
Y
-
S
F
C
--
G
T
V
E
Y
M
A
P
E
-
V
V
N
R
R
-
G
H
T
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
T
L
P
F
---
Q
G
K
-
D
--
R
-
K
-
E
T
M
T
M
I
L
K
A
K
L
G
M
P
Q
F
L
S
P
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
R
L
G
A
G
-
P
-
D
G
V
E
E
I
K
R
H
S
F
F
S
T
I
D
W
N
K
L
Y
R
R
E
I
H
P
P
F
K
P
-------
T
F
Y
F
D
P
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
43
PsiBlast_CBE
49.84
37%
-99
- C1 -
4NUS
1
KS6A3_HUMAN
A:
[30-322]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
Q
F
E
L
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
V
K
K
ISG
S
---
D
---
A
R
Q
L
Y
A
M
K
V
L
K
K
A
T
L
-
K
V
R
D
R
V
-
R
T
K
M
E
-
R
D
I
L
V
E
V
----
N
H
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
---
T
R
L
----
S
K
E
V
----
M
--
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
S
-
L
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
G
H
I
K
L
T
D
F
G
L
S
K
E
-
S
I
D
H
---
E
--
K
-
K
-
A
-
Y
-
S
F
C
--
G
T
V
E
Y
M
A
P
E
-
V
V
N
R
R
-
G
H
T
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
T
L
P
F
---
Q
G
K
-
D
--
R
-
K
-
E
T
M
T
M
I
L
K
A
K
L
G
M
P
Q
F
L
S
P
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
R
L
G
A
G
-
P
-
D
G
V
E
E
I
K
R
H
S
F
F
S
T
I
D
W
N
K
L
Y
R
R
E
I
H
P
P
F
K
P
A
T
------
F
Y
F
D
P
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
73
PsiBlast_CBE
49.55
39%
-98
- C1 -
4L3J
1
KS6B1_HUMAN
A:
[20-300]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
L
L
R
V
L
G
K
G
G
Y
G
K
V
F
Q
V
R
K
VTG
A
---
N
---
T
G
K
I
F
A
M
K
V
L
K
K
A
M
I
-
V
R
N
A
K
D
-
T
A
H
T
K
A
E
R
N
I
L
E
E
V
K
H
---
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
---
M
Q
L
----
E
R
E
G
----
I
--
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
-
K
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
H
Q
G
H
V
K
L
T
D
F
G
L
-
C
K
-
E
--
S
IHD
G
--
T
-
V
-
T
-
H
-
T
F
C
--
G
T
I
E
Y
M
A
P
E
-
I
L
M
R
S
-
G
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
P
P
F
T
G
E
N
R
K
-
K
--
T
----
I
D
K
I
-
L
K
C
K
L
N
L
P
P
Y
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
R
L
G
A
G
-
P
-
G
D
A
G
E
V
Q
A
H
P
F
F
R
H
I
N
W
E
E
L
L
A
R
K
V
E
P
P
F
K
P
L
L
Q
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
45
PsiBlast_CBE
49.27
37%
-107
- C1 -
5D9K
2
?
B:
[30-322]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
Q
F
E
L
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
V
K
K
ISG
S
---
D
---
A
R
Q
L
Y
A
M
K
V
L
K
K
A
T
L
-
K
V
R
D
R
V
-
R
T
K
M
E
-
R
D
I
L
V
E
V
----
N
H
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
---
T
R
L
----
S
K
E
V
----
M
--
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
S
-
L
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
G
H
I
K
L
T
D
F
G
L
S
K
E
---------------------
C
--
G
T
V
E
Y
M
A
P
E
-
V
V
N
R
R
-
G
H
T
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
T
L
P
F
---
Q
G
K
-
D
--
R
-
K
-
E
T
M
T
M
I
L
K
A
K
L
G
M
P
Q
F
L
S
P
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
R
L
G
A
G
-
P
-
D
G
V
E
E
I
K
R
H
S
F
F
S
T
I
D
W
N
K
L
Y
R
R
E
I
H
P
P
F
K
P
-------
T
F
Y
F
D
P
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
115
HHSearch
49.22
38%
-101
- C1 -
3WF7
2
KS6B1_HUMAN
A:
[16-304]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
R
P
E
C
F
E
L
L
R
V
L
G
K
G
G
Y
G
K
V
F
Q
V
R
K
---
V
TGA
N
---
T
G
K
I
F
A
M
K
V
L
K
K
A
M
I
-
V
R
N
A
K
D
T
A
H
T
K
A
-
E
R
N
I
L
E
E
V
---
K
H
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
---
M
Q
L
----
E
R
E
G
----
I
--
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
-
K
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
H
Q
G
H
V
K
L
T
D
F
G
L
C
K
E
-
S
--
I
HD--------
T
-
H
-
T
F
C
--
G
T
I
E
Y
M
A
P
E
-
I
L
M
-
R
S
G
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
P
P
F
T
G
E
N
R
K
------
K
-
T
I
D
K
I
-
L
K
C
K
L
N
L
P
P
Y
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
R
L
G
A
G
-
P
-
G
D
A
G
E
V
Q
A
H
P
F
F
R
H
I
N
W
E
E
L
L
A
R
K
V
E
P
P
F
K
P
L
L
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
41
PsiBlast_CBE
49.11
37%
-93
- C1 -
4NW6
1
KS6A3_HUMAN
A:
[30-322]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
Q
F
E
L
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
V
K
K
I
S
G
S
---
D
---
A
R
Q
L
Y
A
M
K
V
L
K
K
A
T
L
-
K
V
R
D
R
V
-
R
T
K
M
E
-
R
D
I
L
V
E
V
----
N
H
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
---
T
R
L
----
S
K
E
V
----
M
--
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
S
-
L
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
G
H
I
K
L
T
D
F
G
L
S
K
E
-
S
ID
H
---
E
--
K
-
K
-
A
-
Y
-
S
F
C
--
G
T
V
E
Y
M
A
P
E
-
V
V
N
R
R
-
G
H
T
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
T
L
P
F
---
Q
G
K
-
D
--
R
-
K
-
E
T
M
T
M
I
L
K
A
K
L
G
M
P
Q
F
L
S
P
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
R
L
G
A
G
-
P
-
D
G
V
E
E
I
K
R
H
S
F
F
S
T
I
D
W
N
K
L
Y
R
R
E
I
H
P
P
F
K
P
-------
T
F
Y
F
D
P
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
81
PsiBlast_CBE
49.10
33%
-90
- C1 -
2UZW
1
KAPCA_BOVIN
E:
[15-322]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
E
N
P
A
Q
N
T
-
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
---
M
---
E
---
T
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
K
Q
I
E
-
H
-
T
L
N
-
E
K
R
I
L
Q
A
V
---
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
---
S
H
L
----
R
R
I
G
----
R
--
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
----
V
---
K
--
G
-
R
-
T
-
W
-
T
L
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
--
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
-
Q
--
I
-
Y
-
E
---
K
I
V
S
G
K
V
R
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
L
-
K
-
D
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
--
D
Y
E
E
E
E
I
R
-
V
S
I
N
E
---------
K
C
--------
G
K
E
F
S
E
F
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
47
PsiBlast_CBE
49.07
37%
-110
- C1 -
2Z7S
1
KS6A1_HUMAN
A:
[30-308]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
L
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
V
R
K
---
V
TRP
D
---
S
G
H
L
Y
A
M
K
V
L
K
--------------------
I
L
A
D
V
----
N
H
P
F
V
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
---
T
R
L
----
S
K
E
V
----
M
--
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
G
L
D
H
L
H
S
-
L
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
G
H
I
K
L
T
D
F
G
L
S
K
E
------------------------
G
T
V
E
Y
M
A
P
E
-
V
V
N
R
Q
-
G
H
S
H
S
A
D
W
W
S
Y
G
V
L
M
F
E
M
L
T
G
S
L
P
F
---
Q
G
K
-
D
--
R
-
K
-
E
T
M
T
L
I
L
K
A
K
L
G
M
P
Q
F
L
S
T
E
A
Q
S
L
L
R
A
L
F
K
R
N
P
A
N
R
L
G
S
G
-
P
-
D
G
A
E
E
I
K
R
H
V
F
Y
S
T
I
D
W
N
K
L
Y
R
R
E
I
K
P
P
F
K
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
79
PsiBlast_CBE
49.04
33%
-91
- C1 -
2F7X
1
KAPCA_BOVIN
E:
[30-337]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
E
N
P
A
Q
N
T
-
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
---
M
---
E
---
T
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
K
Q
I
E
-
H
-
T
L
N
-
E
K
R
I
L
Q
A
V
---
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
---
S
H
L
----
R
R
I
G
----
R
--
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
-
V
------
K
--
G
-
R
-
T
-
W
-
T
L
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
--
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
-
Q
--
I
-
Y
-
E
---
K
I
V
S
G
K
V
R
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
L
-
K
-
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
--
D
Y
E
E
E
E
I
R
-
V
S
I
N
E
---------
K
C
--------
G
K
E
F
S
E
F
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
78
PsiBlast_CBE
49.01
33%
-95
- C1 -
2F7Z
1
KAPCA_BOVIN
E:
[30-337]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
E
N
P
A
Q
N
T
-
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
---
M
---
E
---
T
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
K
Q
I
E
-
H
-
T
L
N
-
E
K
R
I
L
Q
A
V
---
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
---
S
H
L
----
R
R
I
G
----
R
--
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
-
V
------
K
--
G
-
R
-
T
-
W
-
T
L
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
--
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
-
Q
--
I
-
Y
-
E
---
K
I
V
S
G
K
V
R
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
L
-
K
-
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
--
D
Y
E
E
E
E
I
R
-
V
S
I
N
E
---------
K
C
--------
G
K
E
F
S
E
F
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
46
PsiBlast_CBE
48.96
37%
-109
- C1 -
5D9K
2
?
A:
[30-322]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
Q
F
E
L
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
V
K
K
ISG
S
---
D
---
A
R
Q
L
Y
A
M
K
V
L
K
K
A
T
L
-
K
V
R
D
R
V
-
R
T
K
M
E
-
R
D
I
L
V
E
V
----
N
H
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
---
T
R
L
----
S
K
E
V
----
M
--
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
S
-
L
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
G
H
I
K
L
T
D
F
G
L
S
K
----------------------
C
--
G
T
V
E
Y
M
A
P
E
-
V
V
N
R
R
-
G
H
T
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
T
L
P
F
---
Q
G
K
-
D
--
R
-
K
-
E
T
M
T
M
I
L
K
A
K
L
G
M
P
Q
F
L
S
P
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
R
L
G
A
G
-
P
-
D
G
V
E
E
I
K
R
H
S
F
F
S
T
I
D
W
N
K
L
Y
R
R
E
I
H
P
P
F
K
P
A
T
------
F
Y
F
D
P
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
84
PsiBlast_CBE
48.95
33%
-91
- C1 -
2UZT
1
KAPCA_BOVIN
A:
[15-322]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
E
N
P
A
Q
N
T
-
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
---
M
---
E
---
T
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
K
Q
I
E
-
H
-
T
L
N
-
E
K
R
I
L
Q
A
V
---
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
---
S
H
L
----
R
R
I
G
----
R
--
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
----
V
---
K
--
G
-
R
-
T
-
W
-
T
L
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
--
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
-
Q
--
I
-
Y
-
E
---
K
I
V
S
G
K
V
R
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
L
-
K
-
D
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
--
D
Y
E
E
E
E
I
R
-
V
S
I
N
E
---------
K
C
--------
G
K
E
F
S
E
F
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
80
PsiBlast_CBE
48.75
33%
-89
- C1 -
2F7E
1
KAPCA_BOVIN
E:
[30-337]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
E
N
P
A
Q
N
T
-
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
---
M
---
E
---
T
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
K
Q
I
E
-
H
-
T
L
N
-
E
K
R
I
L
Q
A
V
---
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
---
S
H
L
----
R
R
I
G
----
R
--
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
-
V
------
K
--
G
-
R
-
T
-
W
-
T
L
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
--
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
-
Q
--
I
-
Y
-
E
---
K
I
V
S
G
K
V
R
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
L
-
K
-
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
--
D
Y
E
E
E
E
I
R
-
V
S
I
N
E
---------
K
C
--------
G
K
E
F
S
E
F
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
76
PsiBlast_CBE
48.63
33%
-91
- C1 -
2OJF
1
KAPCA_BOVIN
E:
[30-337]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
E
N
P
A
Q
N
T
-
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
---
M
---
E
---
T
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
K
Q
I
E
-
H
-
T
L
N
-
E
K
R
I
L
Q
A
V
---
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
---
S
H
L
----
R
R
I
G
----
R
--
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
-
V
------
K
--
G
-
R
-
T
-
W
-
T
L
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
--
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
-
Q
--
I
-
Y
-
E
---
K
I
V
S
G
K
V
R
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
L
-
K
-
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
--
D
Y
E
E
E
E
I
R
-
V
S
I
N
E
---------
K
C
--------
G
K
E
F
S
E
F
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
49
PsiBlast_CBE
48.20
37%
-111
- C1 -
2Z7Q
1
KS6A1_HUMAN
A:
[30-308]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
L
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
V
R
K
---
V
TRP
D
---
S
G
H
L
Y
A
M
K
V
L
---------------------
I
L
A
D
V
----
N
H
P
F
V
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
---
T
R
L
----
S
K
E
V
----
M
--
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
G
L
D
H
L
H
S
-
L
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
G
H
I
K
L
T
D
F
G
L
S
K
E
------------------------
G
T
V
E
Y
M
A
P
E
-
V
V
N
R
Q
-
G
H
S
H
S
A
D
W
W
S
Y
G
V
L
M
F
E
M
L
T
G
S
L
P
F
---
Q
G
K
-
D
--
R
-
K
-
E
T
M
T
L
I
L
K
A
K
L
G
M
P
Q
F
L
S
T
E
A
Q
S
L
L
R
A
L
F
K
R
N
P
A
N
R
L
G
S
G
-
P
-
D
G
A
E
E
I
K
R
H
V
F
Y
S
T
I
D
W
N
K
L
Y
R
R
E
I
K
P
P
F
K
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
77
PsiBlast_CBE
48.11
33%
-93
- C1 -
2OH0
1
KAPCA_BOVIN
E:
[30-337]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
E
N
P
A
Q
N
T
-
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
---
M
---
E
---
T
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
K
Q
I
E
-
H
-
T
L
N
-
E
K
R
I
L
Q
A
V
---
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
---
S
H
L
----
R
R
I
G
----
R
--
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
-
V
------
K
--
G
-
R
-
T
-
W
-
T
L
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
--
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
-
Q
--
I
-
Y
-
E
---
K
I
V
S
G
K
V
R
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
L
-
K
-
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
--
D
Y
E
E
E
E
I
R
-
V
S
I
N
E
---------
K
C
--------
G
K
E
F
S
E
F
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
40
PsiBlast_CBE
47.80
37%
-98
- C1 -
5D9L
2
?
A:
[30-322]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
Q
F
E
L
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
V
K
K
I
S
G
S
---
D
---
A
R
Q
L
Y
A
M
K
V
L
K
K
A
T
L
-
K
V
R
D
R
V
-
R
T
K
M
E
-
R
D
I
L
V
E
V
----
N
H
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
---
T
R
L
----
S
K
E
V
----
M
--
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
S
-
L
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
G
H
I
K
L
T
D
F
G
L
S
K
E
------------------------
G
T
V
E
Y
M
A
P
E
-
V
V
N
R
R
-
G
H
T
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
T
L
P
F
---
Q
G
K
-
D
--
R
-
K
-
E
T
M
T
M
I
L
K
A
K
L
G
M
P
Q
F
L
S
P
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
R
L
G
A
G
-
P
-
D
G
V
E
E
I
K
R
H
S
F
F
S
T
I
D
W
N
K
L
Y
R
R
E
I
H
P
P
F
K
P
A
T
G
R
P
E
D
T
F
Y
F
D
P
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
48
PsiBlast_CBE
47.59
37%
-104
- C1 -
2Z7R
1
KS6A1_HUMAN
A:
[30-308]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
L
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
V
R
K
---
V
TRP
D
---
S
G
H
L
Y
A
M
K
V
L
K
K
A
T
L
-
K
V
-------------
I
L
A
D
V
----
N
H
P
F
V
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
---
T
R
L
----
S
K
E
V
----
M
--
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
G
L
D
H
L
H
S
-
L
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
G
H
I
K
L
T
D
F
G
L
S
K
E
------------------------
G
T
V
E
Y
M
A
P
E
-
V
V
N
R
Q
-
G
H
S
H
S
A
D
W
W
S
Y
G
V
L
M
F
E
M
L
T
G
S
L
P
F
---
Q
G
K
-
D
--
R
-
K
-
E
T
M
T
L
I
L
K
A
K
L
G
M
P
Q
F
L
S
T
E
A
Q
S
L
L
R
A
L
F
K
R
N
P
A
N
R
L
G
S
G
-
P
-
D
G
A
E
E
I
K
R
H
V
F
Y
S
T
I
D
W
N
K
L
Y
R
R
E
I
K
P
P
F
K
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
44
PsiBlast_CBE
47.53
37%
-105
- C1 -
3G51
1
KS6A3_MOUSE
A:
[24-304]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
Q
F
E
L
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
V
K
K
ISG
S
---
D
---
A
R
Q
L
Y
A
M
K
V
L
K
K
A
T
L
-
K
V
R
-----------
D
I
L
V
E
V
----
N
H
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
---
T
R
L
----
S
K
E
V
----
M
--
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
S
-
L
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
G
H
I
K
L
T
D
F
G
L
S
K
E
-
S
I----------------------
T
V
E
Y
M
A
P
E
-
V
V
N
R
R
-
G
H
T
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
T
L
P
F
---
Q
G
K
-
D
--
R
-
K
-
E
T
M
T
M
I
L
K
A
K
L
G
M
P
Q
F
L
S
P
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
R
L
G
A
G
-
P
-
D
G
V
E
E
I
K
R
H
S
F
F
S
T
I
D
W
N
K
L
Y
R
R
E
I
H
P
P
F
K
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
102
HHSearch
47.45
33%
-100
- C1 -
3TXO
1
KPCL_HUMAN
A:
[23-347]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
N
F
E
F
I
R
V
L
G
K
G
S
F
G
K
V
M
L
A
R
V
---
K
---
E
---
T
G
D
L
Y
A
V
K
V
L
K
K
D
V
I
-
L
Q
D
D
D
V
-
E
C
T
M
T
-
E
K
R
I
L
S
L
A
--
R
N
H
P
F
L
T
Q
L
F
C
C
F
Q
T
P
D
R
L
F
F
V
M
E
F
V
N
G
G
D
L
M
---
F
H
I
----
Q
K
S
R
----
R
--
F
D
E
A
R
A
R
F
Y
A
A
E
I
I
S
A
L
M
F
L
H
D
-
K
G
I
I
Y
R
D
L
K
L
D
N
V
L
L
D
H
E
G
H
C
K
L
A
D
F
G
M
C
K
E
-
G
--
I
---
C
---------------
G
T
P
D
Y
I
A
P
E
-
I
L
Q
-
E
M
L
Y
G
P
A
V
D
W
W
A
M
G
V
L
L
Y
E
M
L
C
G
H
A
P
F
E
A
E
----
N
--
E
-
D
-
D
L
F
E
A
I
L
N
D
E
V
V
Y
P
T
W
L
H
E
D
A
T
G
I
L
K
S
F
M
T
K
N
P
T
M
R
L
G
S
L
-
T
Q
G
G
E
H
A
I
L
R
H
P
F
F
K
E
I
D
W
A
Q
L
N
H
R
Q
I
E
P
P
F
R
P
R
I
-----
K
S
R
E
D
V
S
N
F
D
P
D
F
I
K
-
E
E
P
V
L
TPIDEGHLP
M
I
--------
N
Q
D
E
F
R
N
F
E
-
Y
-
V
S
P
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
83
PsiBlast_CBE
47.30
33%
-89
- C1 -
2UZU
1
KAPCA_BOVIN
E:
[15-322]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
E
N
P
A
Q
N
T
-
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
---
M
---
E
---
T
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
K
Q
I
E
-
H
-
T
L
N
-
E
K
R
I
L
Q
A
V
---
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
---
S
H
L
----
R
R
I
G
----
R
--
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
----
V
---
K
--
G
-
R
-
T
-
W
-
T
L
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
--
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
-
Q
--
I
-
Y
-
E
---
K
I
V
S
G
K
V
R
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
L
-
K
-
D
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
--
D
Y
E
E
E
E
I
R
-
V
S
I
N
E
---------
K
C
--------
G
K
E
F
S
E
F
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
104
HHSearch
47.13
39%
-99
- C1 -
2R5T
1
SGK1_HUMAN
A:
[32-320]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
P
H
A
K
P
S
D
F
H
F
L
K
V
I
G
K
G
S
F
G
K
V
L
L
A
R
H
---
K
---
A
---
E
E
V
F
Y
A
V
K
V
L
Q
K
K
A
I
-
L
---------------
V
L
--
L
K
N
V
K
H
P
F
L
V
G
L
H
F
S
F
Q
T
A
D
K
L
Y
F
V
L
D
Y
I
N
G
G
E
L
F
---
Y
H
L
----
Q
R
E
R
----
C
--
F
L
E
P
R
A
R
F
Y
A
A
E
I
A
S
A
L
G
Y
L
H
S
-
L
N
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
S
Q
G
H
I
V
L
T
D
F
G
L
C
K
E
-
N
--
I
---
E
H
N
S
-
T
-
T
-
S
-
T
F
C
--
G
T
P
E
Y
L
A
P
E
-
V
L
H
-
K
Q
P
Y
D
R
T
V
D
W
W
C
L
G
A
V
L
Y
E
M
L
Y
G
L
P
P
F
Y
S
R
----
N
--
T
-
A
-
E
M
Y
D
N
I
L
N
K
P
L
Q
L
K
P
N
I
T
N
S
A
R
H
L
L
E
G
L
L
Q
K
D
R
T
K
R
L
G
A
--
K
-
D
D
F
M
E
I
K
S
H
V
F
F
S
L
I
N
W
D
D
L
I
N
K
K
I
T
P
P
F
N
P
N
V
S
-----
G
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
72
PsiBlast_CBE
47.04
39%
-97
- C1 -
4L3L
1
KS6B1_HUMAN
A:
[20-300]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
L
L
R
V
L
G
K
G
G
Y
G
K
V
F
Q
V
R
K
VTG
A
---
N
---
T
G
K
I
F
A
M
K
V
L
K
K
A
M
I
-
V
R
N
A
K
D
-
T
A
H
T
K
A
E
R
N
I
L
E
E
V
K
H
---
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
---
M
Q
L
----
E
R
E
G
----
I
--
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
-
K
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
H
Q
G
H
V
K
L
T
D
F
G
L
-
C
K
-
E
--
S
IHD
G
--
T
-
V
-
T
-
H
-
T
F
C
--
G
T
I
E
Y
M
A
P
E
-
I
L
M
R
S
-
G
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
P
P
F
T
G
E
N
R
K
-
K
--
T
----
I
D
K
I
-
L
K
C
K
L
N
L
P
P
Y
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
R
L
G
A
G
-
P
-
G
D
A
G
E
V
Q
A
H
P
F
F
R
H
I
N
W
E
E
L
L
A
R
K
V
E
P
P
F
K
P
L
L
Q
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
58
PsiBlast_CBE
46.55
38%
-96
- C1 -
2R5T
1
SGK1_HUMAN
A:
[32-320]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
P
H
A
K
P
S
D
F
H
F
L
K
V
I
G
K
G
S
F
G
K
V
L
L
A
R
H
---
K
---
A
---
E
E
V
F
Y
A
V
K
V
L
Q
K
K
A
I
-
L
---------------
V
L
--
L
K
N
V
K
H
P
F
L
V
G
L
H
F
S
F
Q
T
A
D
K
L
Y
F
V
L
D
Y
I
N
G
G
E
L
F
---
Y
H
L
----
Q
R
E
R
----
C
--
F
L
E
P
R
A
R
F
Y
A
A
E
I
A
S
A
L
G
Y
L
H
S
-
L
N
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
S
Q
G
H
I
V
L
T
D
F
G
L
C
K
E
-
N
--
I
---
E
--
H
-
N
-
S
-
T
-
T
S
T
FC
G
T
P
E
Y
L
A
P
E
-
V
L
H
K
Q
-
P
Y
D
R
T
V
D
W
W
C
L
G
A
V
L
Y
E
M
L
Y
G
L
P
P
F
Y
S
R
N
T
A
-
E
--
M
-
Y
-
D
---
N
I
L
N
K
P
L
Q
L
K
P
N
I
T
N
S
A
R
H
L
L
E
G
L
L
Q
K
D
R
T
K
R
L
G
A
--
K
-
D
D
F
M
E
I
K
S
H
V
F
F
S
L
I
N
W
D
D
L
I
N
K
K
I
T
P
P
F
N
P
-----
N
V
S
G
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
51
PsiBlast_CBE
46.20
38%
-95
- C1 -
4GUE
1
KS6A3_MOUSE
A:
[25-305]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
Q
F
E
L
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
V
K
K
ISG
S
---
D
---
A
R
Q
L
Y
A
M
K
V
L
K
K
A
T
L
-
K
V
R
D
R
V
----------
L
V
E
V
----
N
H
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
---
T
R
L
----
S
K
E
V
----
M
--
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
S
-
L
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
G
H
I
K
L
T
D
F
G
L
S
K
E
-----------
K
-
K
-
A
-
Y
-
S
F
C
--
G
T
V
E
Y
M
A
P
E
-
V
V
N
R
R
-
G
H
T
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
T
L
P
F
---
Q
G
K
-
D
--
R
-
K
-
E
T
M
T
M
I
L
K
A
K
L
G
M
P
Q
F
L
S
P
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
R
L
G
A
G
-
P
-
D
G
V
E
E
I
K
R
H
S
F
F
S
T
I
D
W
N
K
L
Y
R
R
E
I
H
P
P
F
K
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
67
PsiBlast_CBE
45.80
38%
-96
- C1 -
3A60
1
KS6B1_HUMAN
A:
[19-299]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
L
L
R
V
L
G
K
G
G
Y
G
K
V
F
Q
V
R
K
V
T
G
A
---
N
---
T
G
K
I
F
A
M
K
V
L
K
K
A
M
-------------
K
A
E
R
N
I
L
E
E
V
K
H
---
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
---
M
Q
L
----
E
R
E
G
----
I
--
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
-
K
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
H
Q
G
H
V
K
L
T
D
F
G
L
C
K
E
-------------------------
T
I
E
Y
M
A
P
E
-
I
L
M
R
S
-
G
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
P
P
F
T
G
E
N
R
K
-
K
--
T
----
I
D
K
I
-
L
K
C
K
L
N
L
P
P
Y
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
R
L
G
A
G
-
P
-
G
D
A
G
E
V
Q
A
H
P
F
F
R
H
I
N
W
E
E
L
L
A
R
K
V
E
P
P
F
K
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
65
PsiBlast_CBE
45.66
38%
-101
- C1 -
3A61
1
KS6B1_HUMAN
A:
[19-299]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
L
L
R
V
L
G
K
G
G
Y
G
K
V
F
Q
V
R
K
V
T
G
A
---
N
---
T
G
K
I
F
A
M
K
V
L
K
-----------------A
E
R
N
I
L
E
E
V
K
H
---
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
---
M
Q
L
----
E
R
E
G
----
I
--
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
-
K
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
H
Q
G
H
V
K
L
T
D
F
G
----------------------------
G
T
I
E
Y
M
A
P
E
-
I
L
M
R
S
-
G
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
P
P
F
T
G
E
N
R
K
-
K
--
T
----
I
D
K
I
-
L
K
C
K
L
N
L
P
P
Y
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
R
L
G
A
G
-
P
-
G
D
A
G
E
V
Q
A
H
P
F
F
R
H
I
N
W
E
E
L
L
A
R
K
V
E
P
P
F
K
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
50
PsiBlast_CBE
45.47
38%
-96
- C1 -
3UBD
1
KS6A3_MOUSE
A:
[24-304]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
Q
F
E
L
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
V
K
K
ISG
S
---
D
---
A
R
Q
L
Y
A
M
K
V
L
K
K
A
T
L
-
K
V
R
D
R
V
--------
D
I
L
V
E
V
----
N
H
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
---
T
R
L
----
S
K
E
V
----
M
--
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
S
-
L
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
G
H
I
K
L
T
D
F
G
L
S
K
E
-----------
K
-
K
-
A
-
Y
-
S
F
C
--
G
T
V
E
Y
M
A
P
E
-
V
V
N
R
R
-
G
H
T
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
T
L
P
F
---
Q
G
K
-
D
--
R
-
K
-
E
T
M
T
M
I
L
K
A
K
L
G
M
P
Q
F
L
S
P
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
R
L
G
A
G
-
P
-
D
G
V
E
E
I
K
R
H
S
F
F
S
T
I
D
W
N
K
L
Y
R
R
E
I
H
P
P
F
K
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
117
HHSearch
45.02
40%
-97
- C1 -
3UBD
1
KS6A3_MOUSE
A:
[21-304]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
P
S
Q
F
E
L
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
V
K
K
---
I
---
S
GSD
A
R
Q
L
Y
A
M
K
V
L
K
K
A
T
L
-
K
V
R
D
R
V
---------
D
I
L
V
E
V
---
N
H
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
---
T
R
L
----
S
K
E
V
----
M
--
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
S
-
L
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
G
H
I
K
L
T
D
F
G
L
S
K
----------E-
K
-
K
-
A
-
Y
-
S
F
C
--
G
T
V
E
Y
M
A
P
E
-
V
V
N
-
R
R
G
H
T
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
T
L
P
F
Q
G
K
D
------
R
-
K
-
E
T
M
T
M
I
L
K
A
K
L
G
M
P
Q
F
L
S
P
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
R
L
G
A
G
-
P
-
D
G
V
E
E
I
K
R
H
S
F
F
S
T
I
D
W
N
K
L
Y
R
R
E
I
H
P
P
F
K
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
56
PsiBlast_CBE
44.64
38%
-94
- C1 -
3HDN
1
SGK1_HUMAN
A:
[32-316]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
P
H
A
K
P
S
D
F
H
F
L
K
V
I
G
K
G
S
F
G
K
V
L
L
A
R
H
---
K
---
A
---
E
E
V
F
Y
A
V
K
V
L
Q
K
K
A
I
-
L
---------------
V
L
--
L
K
N
V
K
H
P
F
L
V
G
L
H
F
S
F
Q
T
A
D
K
L
Y
F
V
L
D
Y
I
N
G
G
E
L
F
---
Y
H
L
----
Q
R
E
R
----
C
--
F
L
E
P
R
A
R
F
Y
A
A
E
I
A
S
A
L
G
Y
L
H
S
-
L
N
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
S
Q
G
H
I
V
L
T
D
F
G
L
C
K
E
-
N
--
I
---
E
--
H
-
N
-
S
-
T
-
T
S
T
FC
G
T
P
E
Y
L
A
P
E
-
V
L
H
K
Q
-
P
Y
D
R
T
V
D
W
W
C
L
G
A
V
L
Y
E
M
L
Y
G
L
P
P
F
Y
S
R
N
T
A
-
E
--
M
-
Y
-
D
---
N
I
L
N
K
P
L
Q
L
K
P
N
I
T
N
S
A
R
H
L
L
E
G
L
L
Q
K
D
R
T
K
R
L
G
A
--
K
-
D
D
F
M
E
I
K
S
H
V
F
F
S
L
I
N
W
D
D
L
I
N
K
K
I
T
P
P
F
N
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
52
PsiBlast_CBE
44.36
38%
-94
- C1 -
4EL9
1
KS6A3_MOUSE
A:
[25-305]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
Q
F
E
L
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
V
K
K
ISG
S
---
D
---
A
R
Q
L
Y
A
M
K
V
L
K
K
A
T
L
-
K
V
R
D
R
V
-
R
------
D
I
L
V
E
V
----
N
H
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
---
T
R
L
----
S
K
E
V
----
M
--
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
S
-
L
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
G
H
I
K
L
T
D
F
G
L
S
K
E
-
S
------
E
--
K
-
K
-
A
-
Y
-
S
F
C
--
G
T
V
E
Y
M
A
P
E
-
V
V
N
R
R
-
G
H
T
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
T
L
P
F
---
Q
G
K
-
D
--
R
-
K
-
E
T
M
T
M
I
L
K
A
K
L
G
M
P
Q
F
L
S
P
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
R
L
G
A
G
-
P
-
D
G
V
E
E
I
K
R
H
S
F
F
S
T
I
D
W
N
K
L
Y
R
R
E
I
H
P
P
F
K
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
57
PsiBlast_CBE
44.29
38%
-90
- C1 -
3HDM
1
SGK1_HUMAN
A:
[32-320]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
P
H
A
K
P
S
D
F
H
F
L
K
V
I
G
K
G
S
F
G
K
V
L
L
A
R
H
---
K
---
A
---
E
E
V
F
Y
A
V
K
V
L
Q
K
K
A
I
-
L
---------------
V
L
--
L
K
N
V
K
H
P
F
L
V
G
L
H
F
S
F
Q
T
A
D
K
L
Y
F
V
L
D
Y
I
N
G
G
E
L
F
---
Y
H
L
----
Q
R
E
R
----
C
--
F
L
E
P
R
A
R
F
Y
A
A
E
I
A
S
A
L
G
Y
L
H
S
-
L
N
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
S
Q
G
H
I
V
L
T
D
F
G
L
C
K
E
-
N
--
I
---
E
--
H
-
N
-
S
-
T
-
T
S
T
FC
G
T
P
E
Y
L
A
P
E
-
V
L
H
K
Q
-
P
Y
D
R
T
V
D
W
W
C
L
G
A
V
L
Y
E
M
L
Y
G
L
P
P
F
Y
S
R
N
T
A
-
E
--
M
-
Y
-
D
---
N
I
L
N
K
P
L
Q
L
K
P
N
I
T
N
S
A
R
H
L
L
E
G
L
L
Q
K
D
R
T
K
R
L
G
A
--
K
-
D
D
F
M
E
I
K
S
H
V
F
F
S
L
I
N
W
D
D
L
I
N
K
K
I
T
P
P
F
N
P
-----
N
V
S
G
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
74
PsiBlast_CBE
43.35
39%
-97
- C1 -
4RLO
4
KS6B1_HUMAN
B:
[7-287]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
L
L
R
V
L
G
K
G
G
Y
G
K
V
F
Q
V
R
K
VTG
A
---
N
---
T
G
K
I
F
A
M
K
V
L
K
K
-------------------------
K
H
---
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
---
M
Q
L
----
E
R
E
G
----
I
--
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
-
K
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
H
Q
G
H
V
K
L
T
D
F
G
L
-
C
K
-
E
--
S
I-------------------
T
I
E
Y
M
A
P
E
-
I
L
M
R
S
-
G
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
P
P
F
T
G
E
N
R
K
-
K
------
T
I
D
K
I
-
L
K
C
K
L
N
L
P
P
Y
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
R
L
G
A
G
-
P
-
G
D
A
G
E
V
Q
A
H
P
F
F
R
H
I
N
W
E
E
L
L
A
R
K
V
E
P
P
F
K
P
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
66
PsiBlast_CBE
42.84
38%
-90
- C1 -
3A60
1
KS6B1_HUMAN
B:
[19-299]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
L
L
R
V
L
G
K
G
G
Y
G
K
V
F
Q
V
R
K
VTG
A
---
N
---
T
G
K
I
F
A
M
K
V
L
K
K
-------------------------
K
H
---
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
---
M
Q
L
----
E
R
E
G
----
I
--
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
-
K
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
H
Q
G
H
V
K
L
T
D
F
G
L
C
K
E
S--------------------
C
--
G
T
I
E
Y
M
A
P
E
-
I
L
M
R
S
-
G
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
P
P
F
T
G
E
N
R
K
-
K
--
T
----
I
D
K
I
-
L
K
C
K
L
N
L
P
P
Y
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
R
L
G
A
G
-
P
-
G
D
A
G
E
V
Q
A
H
P
F
F
R
H
I
N
W
E
E
L
L
A
R
K
V
E
P
P
F
K
P
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
29.11
38%
8
- C1 -
3NYN
2
GRK6_HUMAN
A:
[4-526]
--
E
L
E
N
I
V
A
N
T
V
L
L
K
A
R
E
G
G
G
G
N
--
R
K
G
K
S
K
---
K
W
--
R
----
Q
M
L
Q
F
P
H
I
S
Q
C
E
E
L
R
L
S
L
E
R
D
Y
H
S
L
C
E
R
-----
Q
P
I
G
R
L
L
F
R
E
F
C
A
T
R
P
E
L
S
R
-----
C
----
V
A
F
L
D
G
V
A
E
Y
E
-
V
T
P
D
D
K
R
K
A
C
G
R
Q
L
T
Q
N
F
L
S
H
T
G
P
D
L
-
I
P
E
V
P
R
Q
L
V
T
N
C
T
Q
R
L
-
E
Q
G
P
C
K
-----
D
--
L
F
Q
E
L
T
R
L
T
H
E
Y
L
S
V
A
P
F
A
D
Y
L
D
S
I
Y
F
N
R
F
L
Q
W
K
W
L
E
R
Q
-
P
V
T
K
N
T
F
R
Q
Y
R
V
L
G
K
G
G
F
G
E
V
C
A
C
Q
V
---
R
---
A
---
T
G
K
M
Y
A
C
K
K
L
E
K
K
R
I
-
K
K
R
K
G
E
-
A
M
A
L
N
-
E
K
Q
I
L
E
K
V
N
S
R
---
F
V
V
S
L
A
Y
A
Y
E
T
K
D
A
L
C
L
V
L
T
L
M
N
G
G
D
L
K
F
H
I
Y
H
M
----
G
Q
A
G
-------
F
P
E
A
R
A
V
F
Y
A
A
E
I
C
C
G
L
E
D
L
H
R
-
E
R
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
D
H
G
H
I
R
I
S
D
L
G
L
A
V
H
-
V
--
P
---
E
--
G
-
Q
-
T
I
K
-
G
R
V
--
G
T
V
G
Y
M
A
P
E
-
V
V
-
K
N
E
R
Y
T
F
S
P
D
W
W
A
L
G
C
L
L
Y
E
M
I
A
G
Q
S
P
F
Q
---
K
K
-
I
--
K
-
R
E
E
V
E
R
L
V
K
E
V
P
E
E
Y
S
E
R
F
S
P
Q
A
R
S
L
C
S
Q
L
L
C
K
D
P
A
E
R
L
G
C
R
-
G
-
G
S
A
R
E
V
K
E
H
P
L
F
K
K
L
N
F
K
R
L
G
A
G
M
L
E
P
P
F
K
P
D
P
Q
A
I
Y
C
K
D
V
L
D
I
E
Q
F
S
--
T
V
K
-
G
V
E
L
E
---------
P
T
--------
D
Q
D
F
Y
Q
K
F
A
-
T
G
S
V
P
I
P
W
Q
N
E
M
V
E
T
E
C
-
F
Q
E
L
N
V
F
G
L
D
G
S
V
P
P
D
L
D
W
K
G
Q
P
P
A
P
P
K
K
G
L
L
Q
R
L
F
S
-------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
28.38
38%
9
- C1 -
3NYO
2
GRK6_HUMAN
A:
[4-526]
--
E
L
E
N
I
V
A
N
T
V
L
L
K
A
R
E
G
G
G
G
N
--
R
K
G
K
S
K
---
K
W
--
R
----
Q
M
L
Q
F
P
H
I
S
Q
C
E
E
L
R
L
S
L
E
R
D
Y
H
S
L
C
E
R
-----
Q
P
I
G
R
L
L
F
R
E
F
C
A
T
R
P
E
L
S
R
-----
C
----
V
A
F
L
D
G
V
A
E
Y
E
-
V
T
P
D
D
K
R
K
A
C
G
R
Q
L
T
Q
N
F
L
S
H
T
G
P
D
L
-
I
P
E
V
P
R
Q
L
V
T
N
C
T
Q
R
L
-
E
Q
G
P
C
K
-----
D
--
L
F
Q
E
L
T
R
L
T
H
E
Y
L
S
V
A
P
F
A
D
Y
L
D
S
I
Y
F
N
R
F
L
Q
W
K
W
L
E
R
Q
-
P
V
T
K
N
T
F
R
Q
Y
R
V
L
G
K
G
G
F
G
E
V
C
A
C
Q
V
---
R
---
A
---
T
G
K
M
Y
A
C
K
K
L
E
K
K
R
I
-
K
K
R
K
G
E
-
A
M
A
L
N
-
E
K
Q
I
L
E
K
V
N
S
R
---
F
V
V
S
L
A
Y
A
Y
E
T
K
D
A
L
C
L
V
L
T
L
M
N
G
G
D
L
K
F
H
I
Y
H
M
----
G
Q
A
G
-------
F
P
E
A
R
A
V
F
Y
A
A
E
I
C
C
G
L
E
D
L
H
R
-
E
R
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
D
H
G
H
I
R
I
S
D
L
G
L
A
V
H
-
V
--
P
---
E
--
G
-
Q
-
T
I
K
-
G
R
V
--
G
T
V
G
Y
M
A
P
E
-
V
V
-
K
N
E
R
Y
T
F
S
P
D
W
W
A
L
G
C
L
L
Y
E
M
I
A
G
Q
S
P
F
Q
---
K
K
-
I
--
K
-
R
E
E
V
E
R
L
V
K
E
V
P
E
E
Y
S
E
R
F
S
P
Q
A
R
S
L
C
S
Q
L
L
C
K
D
P
A
E
R
L
G
C
R
-
G
-
G
S
A
R
E
V
K
E
H
P
L
F
K
K
L
N
F
K
R
L
G
A
G
M
L
E
P
P
F
K
P
D
P
Q
A
I
Y
C
K
D
V
L
D
I
E
Q
F
S
--
T
V
K
-
G
V
E
L
E
---------
P
T
--------
D
Q
D
F
Y
Q
K
F
A
-
T
G
S
V
P
I
P
W
Q
N
E
M
V
E
T
E
C
-
F
Q
E
L
N
V
F
G
L
D
G
S
V
P
P
D
L
D
W
K
G
Q
P
P
A
P
P
K
K
G
L
L
Q
R
L
F
S
-------------------------------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
28.26
38%
7
- C1 -
3NYO
2
GRK6_HUMAN
B:
[4-526]
--
E
L
E
N
I
V
A
N
T
V
L
L
K
A
R
E
G
G
G
G
N
--
R
K
G
K
S
K
---
K
W--
R
----
Q
M
L
Q
F
P
H
I
S
Q
C
EE
L
R
L
S
L
E
R
D
Y
H
S
L
C
E
R
-----
Q
P
I
G
R
L
L
F
R
E
F
C
A
T
R
P
E
L
S
R
-----
C
----
V
A
F
L
D
G
V
A
E
Y
E
-
V
T
P
D
D
K
R
K
A
C
G
R
Q
L
TQN
F
L
S
H
T
G
P
D
L
-
I
P
E
V
P
R
Q
L
V
T
N
C
T
Q
R
L
-
E
Q
G
P
C
K
-----
D
--
L
F
Q
E
L
T
R
L
T
H
E
Y
L
S
V
A
P
F
A
D
Y
L
D
S
I
Y
F
N
R
F
L
Q
W
K
W
L
E
R
Q
-
P
V
T
K
N
T
F
R
Q
Y
R
V
L
G
K
G
G
F
G
E
V
C
A
C
Q
V
---
R
---
A
---
T
G
K
M
Y
A
C
K
K
L
E
K
K
R
I
-
K
K
R
K
G
E
-
A
M
A
L
N
-
E
K
Q
I
L
E
K
V
N
S
R
---
F
V
V
S
L
A
Y
A
Y
E
T
K
D
A
L
C
L
V
L
T
L
M
N
G
G
D
L
K
FHI
Y
H
M
----
G
Q
A
G
-------
F
P
E
A
R
A
V
F
Y
A
A
E
I
C
C
G
L
E
D
L
H
R
-
E
R
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
D
H
G
H
I
R
I
S
D
L
G
L
A
V
H
-
V
--
P
---
E
--
G
-
Q
-
T
I
K
-
G
R
V
--
G
T
V
G
Y
M
A
P
E
-
V
V
-
K
N
E
R
Y
T
F
S
P
D
W
W
A
L
G
C
L
L
Y
E
M
I
A
G
Q
S
P
F
Q
---
K
K
-
I
--
K
-
R
E
E
V
E
R
L
V
K
E
V
P
E
E
Y
S
E
R
F
S
P
Q
A
R
S
L
C
S
Q
L
L
C
K
D
P
A
E
R
L
G
C
R
-
G
-
G
S
A
R
E
V
K
E
H
P
L
F
K
K
L
N
F
K
R
L
G
A
G
M
L
E
P
P
F
K
P
D
P
Q
A
I
Y
C
K
D
V
L
D
I
E
Q
F
S
--
T
V
K
-
G
V
E
L
E
---------
P
T
--------
D
Q
D
F
Y
Q
K
F
A
-
T
G
S
V
P
I
P
W
Q
N
E
M
V
E
T
E
C
-
F
Q
E
L
N
V
F
G
L
D
G
S
V
P
P
D
L
D
W
K
G
Q
P
P
A
P
P
K
K
G
L
L
Q
R
L
F
S
-------------------------------------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
28.20
38%
10
- C1 -
3NYN
2
GRK6_HUMAN
B:
[4-526]
--
E
L
E
N
I
V
A
N
T
V
L
L
K
A
R
E
G
G
G
G
N
--
R
K
G
K
S
K
---
K
W--
R
----
Q
M
L
Q
F
P
H
I
S
Q
C
EE
L
R
L
S
L
E
R
D
Y
H
S
L
C
E
R
-----
Q
P
I
G
R
L
L
F
R
E
F
C
A
T
R
P
E
L
S
R
-----
C
----
V
A
F
L
D
G
V
A
E
Y
E
-
V
T
P
D
D
K
R
K
A
C
G
R
Q
L
TQN
F
L
S
H
T
G
P
D
L
-
I
P
E
V
P
R
Q
L
V
T
N
C
T
Q
R
L
-
E
Q
G
P
C
K
-----
D
--
L
F
Q
E
L
T
R
L
T
H
E
Y
L
S
V
A
P
F
A
D
Y
L
D
S
I
Y
F
N
R
F
L
Q
W
K
W
L
E
R
Q
-
P
V
T
K
N
T
F
R
Q
Y
R
V
L
G
K
G
G
F
G
E
V
C
A
C
Q
V
---
R
---
A
---
T
G
K
M
Y
A
C
K
K
L
E
K
K
R
I
-
K
K
R
K
G
E
-
A
M
A
L
N
-
E
K
Q
I
L
E
K
V
N
S
R
---
F
V
V
S
L
A
Y
A
Y
E
T
K
D
A
L
C
L
V
L
T
L
M
N
G
G
D
L
K
FHI
Y
H
M
----
G
Q
A
G
-------
F
P
E
A
R
A
V
F
Y
A
A
E
I
C
C
G
L
E
D
L
H
R
-
E
R
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
D
H
G
H
I
R
I
S
D
L
G
L
A
V
H
-
V
--
P
---
E
--
G
-
Q
-
T
I
K
-
G
R
V
--
G
T
V
G
Y
M
A
P
E
-
V
V
-
K
N
E
R
Y
T
F
S
P
D
W
W
A
L
G
C
L
L
Y
E
M
I
A
G
Q
S
P
F
Q
---
K
K
-
I
--
K
-
R
E
E
V
E
R
L
V
K
E
V
P
E
E
Y
S
E
R
F
S
P
Q
A
R
S
L
C
S
Q
L
L
C
K
D
P
A
E
R
L
G
C
R
-
G
-
G
S
A
R
E
V
K
E
H
P
L
F
K
K
L
N
F
K
R
L
G
A
G
M
L
E
P
P
F
K
P
D
P
Q
A
I
Y
C
K
D
V
L
D
I
E
Q
F
S
--
T
V
K
-
G
V
E
L
E
---------
P
T
--------
D
Q
D
F
Y
Q
K
F
A
-
T
G
S
V
P
I
P
W
Q
N
E
M
V
E
T
E
C
-
F
Q
E
L
N
V
F
G
L
D
G
S
V
P
P
D
L
D
W
K
G
Q
P
P
A
P
P
K
K
G
L
L
Q
R
L
F
S
-------------------------------------------------------------------------------------------------------------------------------
82
PsiBlast_CBE
9.32
33%
19
- C1 -
2UZV
1
KAPCA_BOVIN
A:
[15-322]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
E
N
P
A
Q
N
T
-
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
---
M
---
E
---
T
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
K
Q
I
E
-
H
-
T
L
N
-
E
K
R
I
L
Q
A
V
---
N
F
P
F
L
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K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
---
S
H
L
----
R
R
I
G
----
R
--
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
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Y
L
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S
-
L
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L
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E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
----
V
---
K
--
G
-
R
-
T
-
W
-
T
L
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
--
Y
N
K
A
V
D
W
W
A
L
G
V
L
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Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
-
Q
--
I
-
Y
-
E
---
K
I
V
S
G
K
V
R
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
L
-
K
-
D
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
--
D
Y
E
E
E
E
I
R
-
V
S
I
N
E
---------
K
C
--------
G
K
E
F
S
E
F
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------