@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : ARBK2_HUMAN: (2015-10-03 )
MADLEAVLADVSYLMAMEKSKATPAARASKRIVLPEPSIRSVMQKYLAERNEITFDKIFNQKIGFLLFKDFCLNEINEAVPQVKFYEEIKEYEKLDNEEDRLCRSRQIYDAYIMKELLSCSHPFSKQAVEHVQSHLSKKQVTSTLFQPYIEEICESLRGDIFQKFMESDKFTRFCQWKNVELNIHLTMNEFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGVFSEKEMRFYATEIILGLEHMHNRFVVYRDLKPANILLDEHGHARISDLGLACDFSKKKPHASVGTHGYMAPEVLQKGTAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTVNVELPDTFSPELKSLLEGLLQRDVSKRLGCHGGGSQEVKEHSFFKGVDWQHVYLQKYPPPLIPPRGEVNAADAFDIGSFDEEDTKGIKLLDCDQELYKNFPLVISERWQQEVTETVYEAVNADTDKIEARKRAKNKQLGHEEDYALGKDCIMHGYMLKLGNPFLTQWQRRYFYLFPNRLEWRGEGESRQNLLTMEQILSVEETQIKDKKCILFRIKGGKQFVLQCESDPEFVQWKKELNETFKEAQRLLRRAPKFLNKPRSGTVELPKPSLCHRNSNGL
Atome Classification :
(69 SA)
.........10........20..--......---30--.----........40.......-.50.......-.-60........70........80.----..----.....90........100.......110.....-..120.......130.......140.......150.......160.......170.......180.......190.......200.......210-.---.---.......220.....-..230-......-.240.......250.......260.......270.......280-...----....----.--.290.......300.......310........320.......330......---.340--.---.--.-.-.-.-.350-........360........370.......380.......390.....-.--.-400........410.......420.......430.......440-........450.......460.......470.......480.......490.-.....---------.500-------........510-........520..-.-....530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MA
D
L
E
A
V
L
A
D
V
S
Y
L
M
A
M
E
KSKAT--PAARAS---
K
---
R
----
I
VLP
E
P
S
I
R
S
V
M
Q
K
Y
L
A
-ERNEI
T
F
D
K
I
-
F
-
N
QK
I
G
F
L
L
F
K
D
F
C
L
N
E
I
N
E
AVP
Q
----
V
K
----
F
Y
E
E
I
K
E
Y
E
K
LD
N
E
E
D
R
L
C
R
SR
Q
I
Y
D
A
Y
I
M
K
E
L
-
L
SCSHP
F
S
K
Q
A
V
E
H
V
Q
S
H
L
S
K
K
Q
V
T
S
T
L
F
Q
P
Y
I
E
E
I
C
E
S
L
R
G
D
I
F
Q
K
F
M
ESDKF
T
R
F
C
Q
W
K
N
V
E
L
N
I
H
L
T
MNEF
S
V
H
R
I
IGRGGFGEVYGCRK---A---D---TG
K
M
Y
A
M
K
C
L
D
K
K
R
I
-KMKQG-
E
T
L
ALN-
E
R
I
M
L
S
L
VSTGDC
P
F
I
V
C
M
T
Y
AFHTPD
K
L
C
F
I
L
DLMNGG
D
L
H
---
Y
H
L
----
S
QHG----V--F
S
E
K
E
M
R
F
Y
A
T
E
I
I
L
G
L
E
H
MHN-
R
F
V
V
Y
R
DLK
P
A
N
I
L
LDEHGH
A
R
ISDLGL---ACDF--S---K--K-K-P-H-ASV--GTHGYM
A
P
E
-
V
L
Q
KGTAYDSSA
D
W
F
S
L
G
C
M
L
F
K
L
L
RGHS
P
F
R
QHKTK-
D
--
K
-H-EI
D
R
M
T
L
T
V
N
V
ELPDTF
S
P
E
L
K
S
L
L
E
G
L
L
Q
R
D
V
S
K
R
LGCH-G-G
G
S
Q
E
V
K
E
HSFFKGVD
W
Q
H
V
Y
L
QKYPPPLIPPRGEVNAADAFDIGSFDEEDT-KG
I
K
L
---------LDC--------
D
Q
E
L
Y
K
NF
P
-
L
-
V
I
S
E
R
W
Q
Q
E
V
T
E
T
-
V
-
Y
E
A
VNAD
T
D
K
I
E
A
R
K
RAKNKQLGHEEDYAL
G
K
D
C
I
M
H
G
Y
M
L
KLG
N
P
F
L
T
Q
W
Q
R
R
Y
F
Y
LFPN
R
L
E
WRGEGE
S
R
Q
N
L
L
T
M
E
Q
I
L
S
V
E
E
TQIKDK
K
C
I
L
F
R
IKGG
K
Q
F
V
L
Q
CESD
P
E
F
V
Q
W
K
K
E
L
N
E
T
F
K
E
A
Q
R
L
L
R
R
A
P
K
F
LNKPRSG
T
V
ELPK
P
S
L
CHRNSNGL
13
PsiBlast_PDB
98.58
84%
-107
- C1 -
4MK0
2
ARBK1_HUMAN
A:
[1-639]
----------------------------------
K
---
K
----
I
L
L
P
E
P
S
I
R
S
V
M
Q
K
Y
L
E
-
D
R
G
E
V
T
F
E
K
I
-
F
-
S
Q
K
L
G
Y
L
L
F
R
D
F
C
L
N
H
L
E
E
A
R
P
L
----
V
E
----
F
Y
E
E
I
K
K
Y
E
K
L
E
T
E
E
E
R
V
A
R
S
R
E
I
F
D
S
Y
I
M
K
E
L
-
L
A
C
S
H
P
F
S
K
S
A
T
E
H
V
Q
G
H
L
G
K
K
Q
V
P
P
D
L
F
Q
P
Y
I
E
E
I
C
Q
N
L
R
G
D
V
F
Q
K
F
I
E
S
D
K
F
T
R
F
C
Q
W
K
N
V
E
L
N
I
H
L
T
M
N
D
F
S
V
H
R
I
I
G
R
G
G
F
G
E
V
Y
G
C
R
K
---
A
---
D
---
T
G
K
M
Y
A
M
K
C
L
D
K
K
R
I
-
K
M
K
Q
G
-
E
T
L
A
L
N
-
E
R
I
M
L
S
L
V
S
T
G
D
C
P
F
I
V
C
M
S
Y
A
F
H
T
P
D
K
L
S
F
I
L
D
L
M
N
G
G
D
L
H
---
Y
H
L
----
S
Q
H
G
----
V
--
F
S
E
A
D
M
R
F
Y
A
A
E
I
I
L
G
L
E
H
M
H
N
-
R
F
V
V
Y
R
D
L
K
P
A
N
I
L
L
D
E
H
G
H
V
R
I
S
D
L
G
L
---
A
C
D
F
--
S
---
K
--
K
-
K
-
P
-
H
-
A
S
V
--
G
T
H
G
Y
M
A
P
E
-
V
L
Q
K
G
V
A
Y
D
S
S
A
D
W
F
S
L
G
C
M
L
F
K
L
L
R
G
H
S
P
F
R
Q
H
K
T
K
-
D
--
K
-
H
-
E
I
D
R
M
T
L
T
M
A
V
E
L
P
D
S
F
S
P
E
L
R
S
L
L
E
G
L
L
Q
R
D
V
N
R
R
L
G
C
L
-
G
-
R
G
A
Q
E
V
K
E
S
P
F
F
R
S
L
D
W
Q
M
V
F
L
Q
K
Y
P
P
P
L
I
P
P
R
G
E
V
N
A
A
D
A
F
---------
T
-
K
G
I
K
L
---------
L
D
S
--------
D
Q
E
L
Y
R
N
F
P
-
L
-
T
I
S
E
R
W
Q
Q
E
V
A
E
T
-
V
-
F
D
T
I
N
A
E
T
D
R
L
E
A
R
K
K
A
K
N
K
Q
L
G
H
E
E
D
Y
A
L
G
K
D
C
I
M
H
G
Y
M
S
K
M
G
N
P
F
L
T
Q
W
Q
R
R
Y
F
Y
L
F
P
N
R
L
E
W
R
G
E
G
E
A
P
Q
S
L
L
T
M
E
E
I
Q
S
V
E
E
T
Q
I
K
E
R
K
C
L
L
L
K
I
R
G
G
K
Q
F
I
L
Q
C
D
S
D
P
E
L
V
Q
W
K
K
E
L
R
D
A
Y
R
E
A
Q
Q
L
V
Q
R
V
P
K
M
K
N
K
P
A
-------------------
3
PsiBlast_PDB
98.51
84%
-106
- C1 -
3KRW
1
ARBK1_HUMAN
A:
[29-670]
----------------------------------
K
---
K
----
I
L
L
P
E
P
S
I
R
S
V
M
Q
K
Y
L
E
-
D
R
G
E
V
T
F
E
K
I
-
F
-
S
Q
K
L
G
Y
L
L
F
R
D
F
C
L
N
H
L
E
E
A
R
P
L
----
V
E
----
F
Y
E
E
I
K
K
Y
E
K
L
E
T
E
E
E
R
V
A
R
S
R
E
I
F
D
S
Y
I
M
K
E
L
-
L
A
--
H
P
F
S
K
S
A
T
E
H
V
Q
G
H
L
G
K
K
Q
V
P
P
D
L
F
Q
P
Y
I
E
E
I
C
Q
N
L
R
G
D
V
F
Q
K
F
I
E
S
D
K
F
T
R
F
C
Q
W
K
N
V
E
L
N
I
H
L
T
M
N
D
F
S
V
H
R
I
I
G
R
G
G
F
G
E
V
Y
G
C
R
K
---
A
---
D
---
T
G
K
M
Y
A
M
K
C
L
D
K
K
R
I
-
K
M
K
Q
G
-
E
T
L
A
L
N
-
E
R
I
M
L
S
L
V
S
T
G
D
C
P
F
I
V
C
M
S
Y
A
F
H
T
P
D
K
L
S
F
I
L
D
L
M
N
G
G
D
L
H
---
Y
H
L
----
S
Q
H
G
----
V
--
F
S
E
A
D
M
R
F
Y
A
A
E
I
I
L
G
L
E
H
M
H
N
-
R
F
V
V
Y
R
D
L
K
P
A
N
I
L
L
D
E
H
G
H
V
R
I
S
D
L
G
L
---
A
C
D
F
--
S
---
K
--
K
-
K
-
P
-
H
-
A
S
V
--
G
T
H
G
Y
M
A
P
E
-
V
L
Q
K
G
V
A
Y
D
S
S
A
D
W
F
S
L
G
C
M
L
F
K
L
L
R
G
H
S
P
F
R
Q
H
K
T
K
-
D
--
K
-
H
-
E
I
D
R
M
T
L
T
M
A
V
E
L
P
D
S
F
S
P
E
L
R
S
L
L
E
G
L
L
Q
R
D
V
N
R
R
L
G
C
L
-
G
-
R
G
A
Q
E
V
K
E
S
P
F
F
R
S
L
D
W
Q
M
V
F
L
Q
K
Y
P
P
P
L
I
P
P
R
---------------
E
E
D
T
-
K
G
I
K
L
---------
L
D
S
--------
D
Q
E
L
Y
R
N
F
P
-
L
-
T
I
S
E
R
W
Q
Q
E
V
A
E
T
-
V
-
F
D
T
I
N
A
E
T
D
R
L
E
A
R
K
K
A
K
N
K
Q
L
G
H
E
E
D
Y
A
L
G
K
D
C
I
M
H
G
Y
M
S
K
M
-------
W
Q
R
R
Y
F
Y
L
F
P
N
R
L
E
W
R
G
E
G
E
A
P
Q
S
L
L
T
M
E
E
I
Q
S
V
E
E
T
Q
I
K
E
R
K
C
L
L
L
K
I
R
G
G
K
Q
F
I
L
Q
C
D
S
D
P
E
L
V
Q
W
K
K
E
L
R
D
A
Y
R
E
A
Q
Q
L
V
Q
R
V
P
K
M
K
N
K
P
R
S
P
-----------------
4
PsiBlast_PDB
97.81
84%
-104
- C1 -
3KRX
1
ARBK1_HUMAN
A:
[29-670]
----------------------------------
K
---
K
----
I
L
L
P
E
P
S
I
R
S
V
M
Q
K
Y
L
E
-
D
R
G
E
V
T
F
E
K
I
-
F
-
S
Q
K
L
G
Y
L
L
F
R
D
F
C
L
N
H
L
E
E
A
R
P
L
----
V
E
----
F
Y
E
E
I
K
K
Y
E
K
L
E
T
E
E
E
R
V
A
R
S
R
E
I
F
D
S
Y
I
M
K
E
L
-
L
A
--
H
P
F
S
K
S
A
T
E
H
V
Q
G
H
L
G
K
K
Q
V
P
P
D
L
F
Q
P
Y
I
E
E
I
C
Q
N
L
R
G
D
V
F
Q
K
F
I
E
S
D
K
F
T
R
F
C
Q
W
K
N
V
E
L
N
I
H
L
T
M
N
D
F
S
V
H
R
I
I
G
R
G
G
F
G
E
V
Y
G
C
R
K
---
A
---
D
---
T
G
K
M
Y
A
M
K
C
L
D
K
K
R
I
-
K
M
K
Q
G
-
E
T
L
A
L
N
-
E
R
I
M
L
S
L
V
S
T
G
D
C
P
F
I
V
C
M
S
Y
A
F
H
T
P
D
K
L
S
F
I
L
D
L
M
N
G
G
D
L
H
---
Y
H
L
----
S
Q
H
G
----
V
--
F
S
E
A
D
M
R
F
Y
A
A
E
I
I
L
G
L
E
H
M
H
N
-
R
F
V
V
Y
R
D
L
K
P
A
N
I
L
L
D
E
H
G
H
V
R
I
S
D
L
G
L
---
A
C
D
F
--
S
---
K
--
K
-
K
-
P
-
H
-
A
S
V
--
G
T
H
G
Y
M
A
P
E
-
V
L
Q
K
G
V
A
Y
D
S
S
A
D
W
F
S
L
G
C
M
L
F
K
L
L
R
G
H
S
P
F
R
Q
H
K
T
K
-
D
--
K
-
H
-
E
I
D
R
M
T
L
T
M
A
V
E
L
P
D
S
F
S
P
E
L
R
S
L
L
E
G
L
L
Q
R
D
V
N
R
R
L
G
C
L
-
G
-
R
G
A
Q
E
V
K
E
S
P
F
F
R
S
L
D
W
Q
M
V
F
L
Q
K
Y
P
P
P
L
I
P
P
R
---------------
E
E
D
T
-
K
G
I
K
L
---------
L
D
S
--------
D
Q
E
L
Y
R
N
F
P
-
L
-
T
I
S
E
R
W
Q
Q
E
V
A
E
T
-
V
-
F
D
T
I
N
A
E
T
D
R
L
E
A
R
K
K
A
K
N
K
Q
L
G
H
E
E
D
Y
A
L
G
K
D
C
I
M
H
G
Y
M
S
K
M
-------
W
Q
R
R
Y
F
Y
L
F
P
N
R
L
E
W
R
G
E
G
E
A
P
Q
S
L
L
T
M
E
E
I
Q
S
V
E
E
T
Q
I
K
E
R
K
C
L
L
L
K
I
R
G
G
K
Q
F
I
L
Q
C
D
S
D
P
E
L
V
Q
W
K
K
E
L
R
D
A
Y
R
E
A
Q
Q
L
V
Q
R
V
P
K
M
K
N
K
P
R
S
P
-----------------
2
PsiBlast_PDB
97.78
84%
-105
- C1 -
4PNK
1
ARBK1_HUMAN
A:
[30-668]
----------------------------------
K
---
K
----
I
L
L
P
E
P
S
I
R
S
V
M
Q
K
Y
L
E
-
D
R
G
E
V
T
F
E
K
I
-
F
-
S
Q
K
L
G
Y
L
L
F
R
D
F
C
L
N
H
L
E
E
A
R
P
L
----
V
E
----
F
Y
E
E
I
K
K
Y
E
K
L
E
T
E
E
E
R
V
A
R
S
R
E
I
F
D
S
Y
I
M
K
E
L
-
L
A
C
S
H
P
F
S
K
S
A
T
E
H
V
Q
G
H
L
G
K
K
Q
V
P
P
D
L
F
Q
P
Y
I
E
E
I
C
Q
N
L
R
G
D
V
F
Q
K
F
I
E
S
D
K
F
T
R
F
C
Q
W
K
N
V
E
L
N
I
H
L
T
M
N
D
F
S
V
H
R
I
I
G
R
G
G
F
G
E
V
Y
G
C
R
K
---
A
---
D
---
T
G
K
M
Y
A
M
K
C
L
D
K
K
R
I
-
K
M
K
Q
G
-
E
T
L
A
L
N
-
E
R
I
M
L
S
L
V
S
T
G
D
C
P
F
I
V
C
M
S
Y
A
F
H
T
P
D
K
L
S
F
I
L
D
L
M
N
G
G
D
L
H
---
Y
H
L
----
S
Q
H
G
----
V
--
F
S
E
A
D
M
R
F
Y
A
A
E
I
I
L
G
L
E
H
M
H
N
-
R
F
V
V
Y
R
D
L
K
P
A
N
I
L
L
D
E
H
G
H
V
R
I
S
D
L
G
L
---
A
C
D
F
--
S
---
K
--
K
-
K
-
P
-
H
-
A
S
V
--
G
T
H
G
Y
M
A
P
E
-
V
L
Q
K
G
V
A
Y
D
S
S
A
D
W
F
S
L
G
C
M
L
F
K
L
L
R
G
H
S
P
F
R
Q
H
K
T
K
-
D
--
K
-
H
-
E
I
D
R
M
T
L
T
M
A
V
E
L
P
D
S
F
S
P
E
L
R
S
L
L
E
G
L
L
Q
R
D
V
N
R
R
L
G
C
L
-
G
-
R
G
A
Q
E
V
K
E
S
P
F
F
R
S
L
D
W
Q
M
V
F
L
Q
K
Y
P
P
P
L
I
P
P
R
-
E
V
N
A
-------------
T
-
K
G
I
K
L
---------
L
D
S
--------
D
Q
E
L
Y
R
N
F
P
-
L
-
T
I
S
E
R
W
Q
Q
E
V
A
E
T
-
V
-
F
D
T
I
N
A
E
T
D
R
L
E
A
R
K
K
A
K
N
K
Q
L
G
H
E
E
D
Y
A
L
G
K
D
C
I
M
H
G
Y
M
S
K
M
G
N
P
F
L
T
Q
W
Q
R
R
Y
F
Y
L
F
P
N
R
L
E
W
R
G
E
G
E
A
P
Q
S
L
L
T
M
E
E
I
Q
S
V
E
E
T
Q
I
K
E
R
K
C
L
L
L
K
I
R
G
G
K
Q
F
I
L
Q
C
D
S
D
P
E
L
V
Q
W
K
K
E
L
R
D
A
Y
R
E
A
Q
Q
L
V
Q
R
V
P
K
M
K
N
K
P
--------------------
11
PsiBlast_PDB
97.44
83%
-110
- C1 -
3PVU
1
ARBK1_BOVIN
A:
[30-668]
----------------------------------
K
---
K
----
I
L
L
P
E
P
S
I
R
S
V
M
Q
K
Y
L
E
-
D
R
G
E
V
T
F
E
K
I
-
F
-
S
Q
K
L
G
Y
L
L
F
R
D
F
C
L
K
H
L
E
E
A
K
P
L
----
V
E
----
F
Y
E
E
I
K
K
Y
E
K
L
E
T
E
E
E
R
L
V
C
S
R
E
I
F
D
T
Y
I
M
K
E
L
-
L
A
C
S
H
P
F
S
K
S
A
I
E
H
V
Q
G
H
L
V
K
K
Q
V
P
P
D
L
F
Q
P
Y
I
E
E
I
C
Q
N
L
R
G
D
V
F
Q
K
F
I
E
S
D
K
F
T
R
F
C
Q
W
K
N
V
E
L
N
I
H
L
T
M
N
D
F
S
V
H
R
I
I
G
R
G
G
F
G
E
V
Y
G
C
R
K
---
A
---
D
---
T
G
K
M
Y
A
M
K
C
L
D
K
K
R
I
-
K
M
K
Q
G
-
E
T
L
A
L
N
-
E
R
I
M
L
S
L
V
S
T
G
D
C
P
F
I
V
C
M
S
Y
A
F
H
T
P
D
K
L
S
F
I
L
D
L
M
N
G
G
D
L
H
---
Y
H
L
----
S
Q
H
G
----
V
--
F
S
E
A
D
M
R
F
Y
A
A
E
I
I
L
G
L
E
H
M
H
N
-
R
F
V
V
Y
R
D
L
K
P
A
N
I
L
L
D
E
H
G
H
V
R
I
S
D
L
G
L
---
A
C
D
F
--
S
---
K
--
K
-
K
-
P
-
H
-
A
S
V
--
G
T
H
G
Y
M
A
P
E
-
V
L
Q
K
G
V
A
Y
D
S
S
A
D
W
F
S
L
G
C
M
L
F
K
L
L
R
G
H
S
P
F
R
Q
H
K
T
K
-
D
--
K
-
H
-
E
I
D
R
M
T
L
T
M
A
V
E
L
P
D
S
F
S
P
E
L
R
S
L
L
E
G
L
L
Q
R
D
V
N
R
R
L
G
C
L
-
G
-
R
G
A
Q
E
V
K
E
S
P
F
F
R
S
L
D
W
Q
M
V
F
L
Q
K
Y
P
P
P
L
I
P
P
R
G
----------------------------------
D
S
--------
D
Q
E
L
Y
R
N
F
P
-
L
-
T
I
S
E
R
W
Q
Q
E
V
A
E
T
-
V
-
F
D
T
I
N
A
E
T
D
R
L
E
A
R
K
K
T
K
N
K
Q
L
G
H
E
E
D
Y
A
L
G
K
D
C
I
M
H
G
Y
M
S
K
M
G
------
W
Q
R
R
Y
F
Y
L
F
P
N
R
L
E
W
R
G
E
G
E
A
P
Q
S
L
L
T
M
E
E
I
Q
S
V
E
E
T
Q
I
K
E
R
K
C
L
L
L
K
I
R
G
G
K
Q
F
V
L
Q
C
D
S
D
P
E
L
V
Q
W
K
K
E
L
R
D
A
Y
R
E
A
Q
Q
L
V
Q
R
V
P
K
M
K
N
K
P
--------------------
12
PsiBlast_PDB
97.20
83%
-109
- C1 -
3PVW
1
ARBK1_BOVIN
A:
[29-668]
------------------------------
S
---
K
---
K
----
I
L
L
P
E
P
S
I
R
S
V
M
Q
K
Y
L
E
-
D
R
G
E
V
T
F
E
K
I
-
F
-
S
Q
K
L
G
Y
L
L
F
R
D
F
C
L
K
H
L
E
E
A
K
P
L
----
V
E
----
F
Y
E
E
I
K
K
Y
E
K
L
E
T
E
E
E
R
L
V
C
S
R
E
I
F
D
T
Y
I
M
K
E
L
-
L
A
C
S
H
P
F
S
K
S
A
I
E
H
V
Q
G
H
L
V
K
K
Q
V
P
P
D
L
F
Q
P
Y
I
E
E
I
C
Q
N
L
R
G
D
V
F
Q
K
F
I
E
S
D
K
F
T
R
F
C
Q
W
K
N
V
E
L
N
I
H
L
T
M
N
D
F
S
V
H
R
I
I
G
R
G
G
F
G
E
V
Y
G
C
R
K
---
A
---
D
---
T
G
K
M
Y
A
M
K
C
L
D
K
K
R
I
-
K
M
K
Q
G
-
E
T
L
A
L
N
-
E
R
I
M
L
S
L
V
S
T
G
D
C
P
F
I
V
C
M
S
Y
A
F
H
T
P
D
K
L
S
F
I
L
D
L
M
N
G
G
D
L
H
---
Y
H
L
----
S
Q
H
G
----
V
--
F
S
E
A
D
M
R
F
Y
A
A
E
I
I
L
G
L
E
H
M
H
N
-
R
F
V
V
Y
R
D
L
K
P
A
N
I
L
L
D
E
H
G
H
V
R
I
S
D
L
G
L
---
A
C
D
F
--
S
---
K
--
K
-
K
-
P
-
H
-
A
S
V
--
G
T
H
G
Y
M
A
P
E
-
V
L
Q
K
G
V
A
Y
D
S
S
A
D
W
F
S
L
G
C
M
L
F
K
L
L
R
G
H
S
P
F
R
Q
H
K
T
K
-
D
--
K
-
H
-
E
I
D
R
M
T
L
T
M
A
V
E
L
P
D
S
F
S
P
E
L
R
S
L
L
E
G
L
L
Q
R
D
V
N
R
R
L
G
C
L
-
G
-
R
G
A
Q
E
V
K
E
S
P
F
F
R
S
L
D
W
Q
M
V
F
L
Q
K
Y
P
P
P
L
I
P
P
R
G
----------------------
K
L
---------
L
D
S
--------
D
Q
E
L
Y
R
N
F
P
-
L
-
T
I
S
E
R
W
Q
Q
E
V
A
E
T
-
V
-
F
D
T
I
N
A
E
T
D
R
L
E
A
R
K
K
T
K
N
K
Q
L
G
H
E
E
D
Y
A
L
G
K
D
C
I
M
H
G
Y
M
S
K
M
G
------
W
Q
R
R
Y
F
Y
L
F
P
N
R
L
E
W
R
G
E
G
E
A
P
Q
S
L
L
T
M
E
E
I
Q
S
V
E
E
T
Q
I
K
E
R
K
C
L
L
L
K
I
R
G
G
K
Q
F
V
L
Q
C
D
S
D
P
E
L
V
Q
W
K
K
E
L
R
D
A
Y
R
E
A
Q
Q
L
V
Q
R
V
P
K
M
K
N
K
P
--------------------
87
Fugue
67.41
38%
-86
- C1 -
2ACX
1
GRK6_HUMAN
A:
[14-532]
------------------
K
A
R
K
G
--
K
S
K
K
W
R
---
Q
---
M
----
L
Q
F
P
H
I
S
Q
C
E
E
L
R
L
S
L
E
-
R
D
Y
H
S
L
C
E
R
-----
N
P
I
G
R
L
L
F
R
E
F
C
A
T
R
-
P
E
L
S
R
C
----
V
A
----
F
L
D
G
V
A
E
Y
E
-
V
T
P
D
D
K
R
K
A
C
G
R
N
L
T
Q
N
F
L
S
H
T
G
-
P
D
L
I
P
E
V
P
R
Q
L
V
T
N
C
T
Q
R
L
E
Q
G
P
C
-
K
D
L
F
Q
E
L
T
R
L
T
H
E
Y
L
S
V
A
P
F
A
D
Y
L
D
S
I
Y
F
N
R
F
L
Q
W
K
W
L
E
R
Q
-
P
V
T
K
N
T
F
R
Q
Y
R
V
L
G
K
G
G
F
G
E
V
C
A
C
Q
V
---
R
---
A
---
T
G
K
M
Y
A
C
K
K
L
E
K
K
R
I
-
K
K
R
K
G
-
E
A
M
A
L
N
-
E
K
Q
I
L
E
K
V
N
S
---
R
F
V
V
S
L
A
Y
A
Y
E
T
K
D
A
L
C
L
V
L
T
L
M
N
G
G
D
L
K
---
F
H
I
----
Y
H
M
G
Q
A
--
G
--
F
P
E
A
R
A
V
F
Y
A
A
E
I
C
C
G
L
E
D
L
H
R
-
E
R
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
D
H
G
H
I
R
I
S
D
L
G
L
---
A
V
H
V
--
P
---
E
--
G
-
Q
-
T
-
I
K
G
R
V
--
G
T
V
G
Y
M
A
P
E
-
V
V
-
K
N
E
R
Y
T
F
S
P
D
W
W
A
L
G
C
L
L
Y
E
M
I
A
G
Q
S
P
F
Q
Q
R
K
K
K
I
K
--
R
-
E
-
E
V
E
R
L
V
K
E
V
P
E
E
Y
S
E
R
F
S
P
Q
A
R
S
L
C
S
Q
L
L
C
K
D
P
A
E
R
L
G
C
R
-
G
-
G
S
A
R
E
V
K
E
H
P
L
F
K
K
L
N
F
K
R
L
G
A
G
M
L
E
P
P
F
K
P
D
P
Q
A
I
Y
C
E
-----------------------------
P
T
--------
D
Q
D
F
Y
Q
K
F
A
T
G
-
S
V
P
I
P
W
Q
N
E
M
V
E
T
------------------------------------------------------------------------------------------------------------------------------
E
C
F
Q
E
L
N
--------------------------
V
F
G
L
D
G
S
20
PsiBlast_PDB
67.28
36%
-87
- C1 -
4YHJ
1
?
A:
[25-519]
---------------------------
G
R
S
K
---
K
---
W
K
E
I
-
L
T
L
P
P
V
S
Q
C
S
E
L
R
H
S
I
E
-
K
D
Y
S
S
L
C
D
K
-----
Q
P
I
G
R
R
L
F
R
Q
F
C
-----
D
T
K
P
T
----
L
K
R
H
I
E
F
L
D
A
V
A
E
Y
E
V
A
D
D
E
D
R
S
D
C
-
G
L
S
I
L
D
R
F
F
N
D
K
L
-
A
A
P
L
P
E
I
P
P
D
V
V
T
E
C
R
L
G
L
K
E
E
N
P
S
K
K
A
F
E
E
C
T
R
V
A
H
N
Y
L
R
G
E
P
F
E
E
Y
Q
E
S
S
Y
F
S
Q
F
L
Q
W
K
W
L
E
R
Q
-
P
V
T
K
N
T
F
R
H
Y
R
V
L
G
K
G
G
F
G
E
V
C
A
C
Q
V
---
R
---
A
---
T
G
K
M
Y
A
C
K
K
L
Q
K
K
R
I
-
K
K
R
K
G
-
E
A
M
A
L
N
-
E
K
R
I
L
E
K
V
Q
S
R
---
F
V
V
S
L
A
Y
A
Y
E
T
K
D
A
L
C
L
V
L
T
I
M
N
G
G
D
L
K
---
F
H
I
----
Y
N
L
G
NP--
G
--
F
D
E
Q
R
A
V
F
Y
A
A
E
L
C
C
G
L
E
D
L
Q
R
-
E
R
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
D
R
G
H
I
R
I
S
D
L
G
L
---
A
T
E
I
--
P
---
E
G-
Q
-
R
-
V
-
R
-
G
R
V
--
G
T
V
G
Y
M
A
P
E
-
V
V
N
-
N
E
K
Y
T
F
S
P
D
W
W
G
L
G
C
L
I
Y
E
M
I
Q
G
H
S
P
F
K
K
Y
K
E
K
-
V
--
K
W
E
-
E
V
D
Q
R
I
K
N
D
T
E
E
Y
S
E
K
F
S
E
D
A
K
S
I
C
R
M
L
L
T
K
N
P
S
K
R
L
G
C
R
-
G
-
E
G
A
A
G
V
K
Q
H
P
V
F
K
D
I
N
F
R
R
L
E
A
N
M
L
E
P
P
F
C
P
D
P
H
A
V
Y
C
K
D
V
L
D
I
E
Q
F
S
V
--
V
-
K
G
I
Y
L
---------
D
T
A
--------
D
E
D
F
Y
A
R
F
A
-
T
G
C
V
S
I
P
W
Q
N
E
M
I
E
S
-
G
-
C
F
K
D
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------
24
PsiBlast_CBE
67.14
36%
-90
- C1 -
4YHJ
1
?
B:
[25-519]
---------------------------
G
R
S
K
---
K
---
W
KEI-
L
T
L
P
P
V
S
Q
C
S
E
L
R
H
S
I
E
-
K
D
Y
S
S
L
C
D
K
-----
Q
P
I
G
R
R
L
F
R
Q
F
C
-----
D
T
K
P
T
----
L
K
RHIE
F
L
D
A
V
A
E
Y
E
V
A
D
D
E
D
R
S
D
C
-
G
L
S
I
L
D
R
F
F
N
D
K
L
-
A
A
P
L
P
E
I
P
P
D
V
V
T
E
C
R
L
G
L
K
E
E
N
P
S
K
K
A
F
E
E
C
T
R
V
A
H
N
Y
L
R
G
E
P
F
E
E
Y
Q
E
S
S
Y
F
S
Q
F
L
Q
W
K
W
L
E
R
Q
-
P
V
T
K
N
T
F
R
H
Y
R
V
L
G
K
G
G
F
G
E
V
C
A
C
Q
V
---
R
---
A
---
T
G
K
M
Y
A
C
K
K
L
Q
K
K
R
I
-
K
K
R
K
G
-
E
A
M
A
L
N
-
E
K
R
I
L
E
K
V
Q
S
R
---
F
V
V
S
L
A
Y
A
Y
E
T
K
D
A
L
C
L
V
L
T
I
M
N
G
G
D
L
K
---
F
H
I
----
Y
N
L
G
NP--
G
--
F
D
E
Q
R
A
V
F
Y
A
A
E
L
C
C
G
L
E
D
L
Q
R
-
E
R
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
D
R
G
H
I
R
I
S
D
L
G
L
---
A
T
E
I
--
P
---
E
G-
Q
-
R
-
V
-
R
-
G
R
V
--
G
T
V
G
Y
M
A
P
E
-
V
V
N
-
N
E
K
Y
T
F
S
P
D
W
W
G
L
G
C
L
I
Y
E
M
I
Q
G
H
S
P
F
K
K
Y
K
E
K
-
V
--
K
W
E
-
E
V
D
Q
R
I
K
N
D
T
E
E
Y
S
E
K
F
S
E
D
A
K
S
I
C
R
M
L
L
T
K
N
P
S
K
R
L
G
C
R
-
G
-
E
G
A
A
G
V
K
Q
H
P
V
F
K
D
I
N
F
R
R
L
E
A
N
M
L
E
P
P
F
C
P
D
P
H
A
V
Y
C
----------------
G
I
Y
L
---------
D
T
A
--------
D
E
D
F
Y
A
R
F
A
-
T
G
C
V
S
I
P
W
Q
N
E
M
I
E
S
-
G
-
C
F
K
D
I
N
K
------------------------------------------------------------------------------------------------------------------------------------------------------------
98
HHSearch
67.01
39%
-94
- C1 -
2ACX
1
GRK6_HUMAN
A:
[14-526]
--------------
K
A
R
---------
K
G
K
-
S
---
K
---
K
W
R
Q
M
L
Q
F
P
H
I
S
Q
C
----
E
E
L
R
-
L
S
L
E
R
D
Y
H
S
L
C
E
-
R
N
P
I
G
R
L
L
F
R
E
F
C
A
T
R
-
P
E
L
S
R
C
----
V
A
----
F
L
D
G
V
A
E
Y
E
V
T
P
-
D
D
K
R
K
A
C
G
R
N
L
T
Q
N
F
L
S
H
T
G
-
P
D
L
I
P
E
V
P
R
Q
L
V
T
N
C
T
Q
R
L
E
-
Q
G
P
C
K
D
L
F
Q
E
L
T
R
L
T
H
E
Y
L
S
V
A
P
F
A
D
Y
L
D
S
I
Y
F
N
R
F
L
Q
W
K
W
L
E
R
Q
-
P
V
T
K
N
T
F
R
Q
Y
R
V
L
G
K
G
G
F
G
E
V
C
A
C
Q
V
---
R
---
A
---
T
G
K
M
Y
A
C
K
K
L
E
K
K
R
I
-
K
K
R
K
G
-
E
A
M
A
L
N
-
E
K
Q
I
L
E
K
V
---
N
S
R
F
V
V
S
L
A
Y
A
Y
E
T
K
D
A
L
C
L
V
L
T
L
M
N
G
G
D
L
K
---
F
H
I
----
Y
H
M
G
Q
A
--
G
--
F
P
E
A
R
A
V
F
Y
A
A
E
I
C
C
G
L
E
D
L
H
R
-
E
R
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
D
H
G
H
I
R
I
S
D
L
G
L
---
A
V
H
V
--
P
---
E
--
G
Q
T
-
I
-
K
-
G
R
V
--
G
T
V
G
Y
M
A
P
E
-
V
V
K
-
N
E
R
Y
T
F
S
P
D
W
W
A
L
G
C
L
L
Y
E
M
I
A
G
Q
S
P
F
Q
Q
R
K
K
K
I
K
--
R
-
E
-
E
V
E
R
L
V
K
E
V
P
E
E
Y
S
E
R
F
S
P
Q
A
R
S
L
C
S
Q
L
L
C
K
D
P
A
E
R
L
G
C
R
-
G
-
G
S
A
R
E
V
K
E
H
P
L
F
K
K
L
N
F
K
R
L
G
A
G
M
L
E
P
P
F
K
P
D
P
Q
A
I
Y
C
-----------------------------
E
P
T
--------
D
Q
D
F
Y
Q
K
F
A
-
T
G
S
V
P
I
P
W
Q
N
E
M
V
E
T
-
E
C
F
Q
E
L
N
V
F
G
L
D
G
S
-------------------------------------------------------------------------------------------------------------------------------------------------------
31
PsiBlast_CBE
66.77
34%
-98
- C1 -
3C4X
1
RK_BOVIN
B:
[31-522]
----------------------------
R
D
R
---
K
Y
L
A
R
----
L
K
L
P
P
L
S
K
C
E
A
L
R
E
S
L
-----
D
L
G
F
E
G
M
C
L
-
E
Q
P
I
G
K
R
L
F
Q
Q
F
-
L
R
T
H
E
Q
H
G
P
A
----
L
Q
----
L
W
K
D
I
E
D
Y
D
T
A
D
D
A
L
-
R
P
Q
K
A
Q
A
L
R
A
A
Y
L
E
P
Q
A
Q
L
F
C
S
F
-
L
D
A
E
T
V
A
R
-----
A
--------
F
Q
P
L
L
R
A
V
L
A
H
L
G
Q
A
P
F
Q
E
F
L
D
S
L
Y
F
L
R
F
L
Q
W
K
W
L
E
A
Q
-
P
M
G
E
D
W
F
L
D
F
R
V
L
G
R
G
G
F
G
E
V
F
A
C
Q
M
---
K
---
A
---
T
G
K
L
Y
A
C
K
K
L
N
K
K
R
L
-
K
K
R
K
G
-
Y
Q
G
A
M
V
-
E
K
K
I
L
A
K
V
H
S
---
R
F
I
V
S
L
A
Y
A
F
E
T
K
T
D
L
C
L
V
M
T
I
M
N
G
G
D
I
R
---
Y
H
I
Y
NVD
E
D
N
P
----
G
--
F
Q
E
P
R
A
I
F
Y
T
A
Q
I
V
S
G
L
E
H
L
H
Q
-
R
N
I
I
Y
R
D
L
K
P
E
N
V
L
L
D
D
D
G
N
V
R
I
S
D
L
G
L
---
A
V
E
L
K
A
G
---
Q
--
T
-
K
-
T
-
K
-
G
Y
A
--
G
T
P
G
F
M
A
P
E
-
L
L
L
-
G
E
E
Y
D
F
S
V
D
Y
F
A
L
G
V
T
L
Y
E
M
I
A
A
R
G
P
F
R
A
R
G
E
K
V
E
--
N
-
K
-
E
L
K
Q
R
V
L
E
Q
A
V
T
Y
P
D
K
F
S
P
A
S
K
D
F
C
E
A
L
L
Q
K
D
P
E
K
R
L
G
F
R
-
D
-
G
S
C
D
G
L
R
T
H
P
L
F
R
D
I
S
W
R
Q
L
E
A
G
M
L
T
P
P
F
V
P
D
S
R
T
--------------------------------
E
K
A
--------
D
T
E
F
F
Q
E
F
A
-
S
G
T
C
P
I
P
W
Q
E
E
M
I
E
T
-
G
-
V
F
G
D
L
N
V
W
R
P
---------------------------------------------------------------------------------------------------------------------------------------------------------
32
PsiBlast_CBE
66.51
34%
-92
- C1 -
3C4X
1
RK_BOVIN
A:
[30-522]
---------------------------
S
R
D
R
---
K
Y
L
A
R
----
L
K
L
P
P
L
S
K
C
E
A
L
R
E
S
L
-----
D
L
G
F
E
G
M
C
L
-
E
Q
P
I
G
K
R
L
F
Q
Q
F
-
L
R
T
H
E
Q
H
G
P
A
----
L
Q
----
L
W
K
D
I
E
D
Y
D
T
A
D
D
A
L
-
R
P
Q
K
A
Q
A
L
R
A
A
Y
L
E
P
Q
A
Q
L
F
C
S
F
-
L
D
A
E
T
V
A
R
-----
A
R
A
G
A
G
D
G
L
F
Q
P
L
L
R
A
V
L
A
H
L
G
Q
A
P
F
Q
E
F
L
D
S
L
Y
F
L
R
F
L
Q
W
K
W
L
E
A
Q
-
P
M
G
E
D
W
F
L
D
F
R
V
L
G
R
G
G
F
G
E
V
F
A
C
Q
M
---
K
---
A
---
T
G
K
L
Y
A
C
K
K
L
N
K
K
R
L
-
K
K
R
K
G
-
Y
Q
G
A
M
V
-
E
K
K
I
L
A
K
V
H
S
---
R
F
I
V
S
L
A
Y
A
F
E
T
K
T
D
L
C
L
V
M
T
I
M
N
G
G
D
I
R
---
Y
H
I
Y
N
VD
E
D
N
P
----
G
--
F
Q
E
P
R
A
I
F
Y
T
A
Q
I
V
S
G
L
E
H
L
H
Q
-
R
N
I
I
Y
R
D
L
K
P
E
N
V
L
L
D
D
D
G
N
V
R
I
S
D
L
G
L
---
A
V
E
L
K
A
G
---
Q
--
T
-
K
-
T
-
K
-
G
Y
A
--
G
T
P
G
F
M
A
P
E
-
L
L
L
-
G
E
E
Y
D
F
S
V
D
Y
F
A
L
G
V
T
L
Y
E
M
I
A
A
R
G
P
F
R
A
R
G
E
K
V
E
--
N
-
K
-
E
L
K
Q
R
V
L
E
Q
A
V
T
Y
P
D
K
F
S
P
A
S
K
D
F
C
E
A
L
L
Q
K
D
P
E
K
R
L
G
F
R
-
D
-
G
S
C
D
G
L
R
T
H
P
L
F
R
D
I
S
W
R
Q
L
E
A
G
M
L
T
P
P
F
V
P
D
--------
I
Q
D
V
G
A
F
S
T
--
V
-
K
G
V
A
F
---------
E
K
A
--------
D
T
E
F
F
Q
E
F
A
-
S
G
T
C
P
I
P
W
Q
E
E
M
I
E
T
-
G
-
V
F
G
D
L
N
V
W
R
P
---------------------------------------------------------------------------------------------------------------------------------------------------------
30
PsiBlast_CBE
66.47
34%
-97
- C1 -
3C4Z
1
RK_BOVIN
A:
[31-522]
----------------------------
R
D
R
---
K
Y
L
A
R
----
L
K
L
P
P
L
S
K
C
E
A
L
R
E
S
L
-----
D
L
G
F
E
G
M
C
L
-
E
Q
P
I
G
K
R
L
F
Q
Q
F
-
L
R
T
H
E
Q
H
G
P
A
----
L
Q
----
L
W
K
D
I
E
D
Y
D
T
A
D
D
A
L
-
R
P
Q
K
A
Q
A
L
R
A
A
Y
L
E
P
Q
A
Q
L
F
C
S
F
-
L
D
A
E
T
V
A
R
-----
A
R
A
G
---
G
L
F
Q
P
L
L
R
A
V
L
A
H
L
G
Q
A
P
F
Q
E
F
L
D
S
L
Y
F
L
R
F
L
Q
W
K
W
L
E
A
Q
-
P
M
G
E
D
W
F
L
D
F
R
V
L
G
R
G
G
F
G
E
V
F
A
C
Q
M
---
K
---
A
---
T
G
K
L
Y
A
C
K
K
L
N
K
K
R
L
-
K
K
R
K
G
-
Y
Q
G
A
M
V
-
E
K
K
I
L
A
K
V
H
S
---
R
F
I
V
S
L
A
Y
A
F
E
T
K
T
D
L
C
L
V
M
T
I
M
N
G
G
D
I
R
---
Y
H
I
YNVD
E
D
N
P
----
G
--
F
Q
E
P
R
A
I
F
Y
T
A
Q
I
V
S
G
L
E
H
L
H
Q
-
R
N
I
I
Y
R
D
L
K
P
E
N
V
L
L
D
D
D
G
N
V
R
I
S
D
L
G
L
---
A
V
E
L
K
A
G
---
Q
--
T
-
K
-
T
-
K
-
G
Y
A
--
G
T
P
G
F
M
A
P
E
-
L
L
L
-
G
E
E
Y
D
F
S
V
D
Y
F
A
L
G
V
T
L
Y
E
M
I
A
A
R
G
P
F
R
A
R
G
E
K
V
E
--
N
-
K
-
E
L
K
Q
R
V
L
E
Q
A
V
T
Y
P
D
K
F
S
P
A
S
K
D
F
C
E
A
L
L
Q
K
D
P
E
K
R
L
G
F
R
-
D
-
G
S
C
D
G
L
R
T
H
P
L
F
R
D
I
S
W
R
Q
L
E
A
G
M
L
T
P
P
F
V
P
D
S
R
T
V
Y
A
K
N
----
G
A
F
S
------
G
V
A
F
---------
E
K
A
--------
D
T
E
F
F
Q
E
F
A
-
S
G
T
C
P
I
P
W
Q
E
E
M
I
E
T
-
G
-
V
F
G
D
L
N
V
W
R
P
---------------------------------------------------------------------------------------------------------------------------------------------------------
29
PsiBlast_CBE
65.85
34%
-90
- C1 -
3C50
1
RK_BOVIN
B:
[30-522]
---------------------------
S
R
D
R
---
K
YLA
R
----
L
K
L
P
P
L
S
K
C
E
A
L
R
E
S
L
-----
D
L
G
F
E
G
M
C
L
-
E
Q
P
I
G
K
R
L
F
Q
Q
F
-
L
R
T
H
E
Q
H
G
P
A
----
L
Q
----
L
W
K
D
I
E
D
Y
D
T
A
D
D
A
L
-
R
P
Q
K
A
Q
A
L
R
A
A
Y
L
E
P
Q
A
Q
L
F
C
S
F
-
L
D
A
E
T
V
A
R
-----
A
R
A
G
A
G
D
G
L
F
Q
P
L
L
R
A
V
L
A
H
L
G
Q
A
P
F
Q
E
F
L
D
S
L
Y
F
L
R
F
L
Q
W
K
W
L
E
A
Q
-
P
M
G
E
D
W
F
L
D
F
R
V
L
G
R
G
G
F
G
E
V
F
A
C
Q
M
---
K
---
A
---
T
G
K
L
Y
A
C
K
K
L
N
K
K
R
L
-
K
K
R
K
G
-
Y
Q
G
A
M
V
-
E
K
K
I
L
A
K
V
H
S
---
R
F
I
V
S
L
A
Y
A
F
E
T
K
T
D
L
C
L
V
M
T
I
M
N
G
G
D
I
R
---
Y
H
I
YNVD
E
D
N
P
----
G
--
F
Q
E
P
R
A
I
F
Y
T
A
Q
I
V
S
G
L
E
H
L
H
Q
-
R
N
I
I
Y
R
D
L
K
P
E
N
V
L
L
D
D
D
G
N
V
R
I
S
D
L
G
L
---
A
V
E
L
KA
G
---
Q
--
T
-
K
-
T
-
K
-
G
Y
A
--
G
T
P
G
F
M
A
P
E
-
L
L
L
-
G
E
E
Y
D
F
S
V
D
Y
F
A
L
G
V
T
L
Y
E
M
I
A
A
R
G
P
F
R
A
R
G
E
K
V
E
--
N
-
K
-
E
L
K
Q
R
V
L
E
Q
A
V
T
Y
P
D
K
F
S
P
A
S
K
D
F
C
E
A
L
L
Q
K
D
P
E
K
R
L
G
F
R
-
D
-
G
S
C
D
G
L
R
T
H
P
L
F
R
D
I
S
W
R
Q
L
E
A
G
M
L
T
P
P
F
V
P
D
S
R
T
V
Y
A
--------
F
S
T
--
V
-
K
G
V
A
F
---------
E
K
A
--------
D
T
E
F
F
Q
E
F
A
-
S
G
T
C
P
I
P
W
Q
E
E
M
I
E
T
-
G
-
V
F
G
D
L
N
V
W
R
P
---------------------------------------------------------------------------------------------------------------------------------------------------------
97
HHSearch
65.75
35%
-93
- C1 -
3C4Z
1
RK_BOVIN
A:
[31-533]
----------------------------
R
D
R
K
Y
L
A
---
R
----
L
K
L
P
P
L
S
K
C
E
A
----
L
R
-
E
S
L
D
L
G
F
E
G
M
C
L
-
E
Q
P
I
G
K
R
L
F
Q
Q
F
L
R
T
H
-
E
Q
H
G
P
A
----
L
Q
----
L
W
K
D
I
E
D
Y
D
-
T
A
D
D
A
L
R
P
Q
K
A
Q
A
L
R
A
A
Y
L
E
P
Q
A
-
Q
L
F
C
S
F
L
D
A
E
T
V
A
R
A
R
A
-----
G
---
G
L
F
Q
P
L
L
R
A
V
L
A
H
L
G
Q
A
P
F
Q
E
F
L
D
S
L
Y
F
L
R
F
L
Q
W
K
W
L
E
A
Q
-
P
M
G
E
D
W
F
L
D
F
R
V
L
G
R
G
G
F
G
E
V
F
A
C
Q
M
---
K
---
A
---
T
G
K
L
Y
A
C
K
K
L
N
K
K
R
L
-
K
K
R
K
G
-
Y
Q
G
A
M
V
-
E
K
K
I
L
A
K
V
---
H
S
R
F
I
V
S
L
A
Y
A
F
E
T
K
T
D
L
C
L
V
M
T
I
M
N
G
G
D
I
R
---
Y
H
I
----
Y
N
V
D
ED
N
P
G
--
F
Q
E
P
R
A
I
F
Y
T
A
Q
I
V
S
G
L
E
H
L
H
Q
-
R
N
I
I
Y
R
D
L
K
P
E
N
V
L
L
D
D
D
G
N
V
R
I
S
D
L
G
L
---
A
V
E
L
--
K
---
A
GQ
T
-
K
-
T
-
K
-
G
Y
A
--
G
T
P
G
F
M
A
P
E
-
L
L
L
-
G
E
E
Y
D
F
S
V
D
Y
F
A
L
G
V
T
L
Y
E
M
I
A
A
R
G
P
F
R
A
R
G
E
K
V
E
--
N
-
K
-
E
L
K
Q
R
V
L
E
Q
A
V
T
Y
P
D
K
F
S
P
A
S
K
D
F
C
E
A
L
L
Q
K
D
P
E
K
R
L
G
F
R
-
D
-
G
S
C
D
G
L
R
T
H
P
L
F
R
D
I
S
W
R
Q
L
E
A
G
M
L
T
P
P
F
V
P
D
S
R
T
V
Y
A
K
N
----
G
A
F
S
------
G
V
A
F
---------
E
K
A
--------
D
T
E
F
F
Q
E
F
A
-
S
G
T
C
P
I
P
W
Q
E
E
M
I
E
T
G
V
-
F
G
D
L
N
V
W
R
P
----------------------------------------------------------------------------------------------------------------------------------------------------------
38
PsiBlast_CBE
65.74
34%
-93
- C1 -
3C4W
1
RK_BOVIN
A:
[31-522]
----------------------------
R
D
R
---
K
Y
L
A
R
----
L
K
L
P
P
L
S
K
C
E
A
L
R
E
S
L
-----
D
L
G
F
E
G
M
C
L
-
E
Q
P
I
G
K
R
L
F
Q
Q
F
-
L
R
T
H
E
Q
H
G
P
A
----
L
Q
----
L
W
K
D
I
E
D
Y
D
T
A
D
D
A
L
-
R
P
Q
K
A
Q
A
L
R
A
A
Y
L
E
P
Q
A
Q
L
F
C
S
F
L
D
A
E
T
V
A
R
------
A
R
A
G
A
G
D
G
L
F
Q
P
L
L
R
A
V
L
A
H
L
G
Q
A
P
F
Q
E
F
L
D
S
L
Y
F
L
R
F
L
Q
W
K
W
L
E
A
Q
-
P
M
G
E
D
W
F
L
D
F
R
V
L
G
R
G
G
F
G
E
V
F
A
C
Q
M
---
K
---
A
---
T
G
K
L
Y
A
C
K
K
L
N
K
K
R
L
-
K
K
R
K
G
-
Y
Q
G
A
M
V
-
E
K
K
I
L
A
K
V
H
S
---
R
F
I
V
S
L
A
Y
A
F
E
T
K
T
D
L
C
L
V
M
T
I
M
N
G
G
D
I
R
---
Y
H
I
Y
N
VD
E
D
N
P
----
G
--
F
Q
E
P
R
A
I
F
Y
T
A
Q
I
V
S
G
L
E
H
L
H
Q
-
R
N
I
I
Y
R
D
L
K
P
E
N
V
L
L
D
D
D
G
N
V
R
I
S
D
L
G
L
---
A
V
E
L
K
A
G
---
Q
--
T
-
K
-
T
-
K
-
G
Y
A
--
G
T
P
G
F
M
A
P
E
-
L
L
L
-
G
E
E
Y
D
F
S
V
D
Y
F
A
L
G
V
T
L
Y
E
M
I
A
A
R
G
P
F
R
A
R
G
E
K
V
E
--
N
-
K
-
E
L
K
Q
R
V
L
E
Q
A
V
T
Y
P
D
K
F
S
P
A
S
K
D
F
C
E
A
L
L
Q
K
D
P
E
K
R
L
G
F
R
-
D
-
G
S
C
D
G
L
R
T
H
P
L
F
R
D
I
S
W
R
Q
L
E
A
G
M
L
T
P
P
F
V
P
D
---------
Q
D
V
G
A
F
S
T
--
V
-
K
G
V
A
F
---------
E
K
A
--------
D
T
E
F
F
Q
E
F
A
-
S
G
T
C
P
I
P
W
Q
E
E
M
I
E
T
-
G
-
V
F
G
D
L
N
V
W
R
P
---------------------------------------------------------------------------------------------------------------------------------------------------------
28
PsiBlast_CBE
65.50
34%
-92
- C1 -
3C51
1
RK_BOVIN
A:
[31-522]
----------------------------
R
D
R
---
K
Y
L
A
R
----
L
K
L
P
P
L
S
K
C
E
A
L
R
E
S
L
-----
D
L
G
F
E
G
M
C
L
-
E
Q
P
I
G
K
R
L
F
Q
Q
F
-
L
R
T
H
E
Q
H
G
P
A
----
L
Q
----
L
W
K
D
I
E
D
Y
D
T
A
D
D
A
L
-
R
P
Q
K
A
Q
A
L
R
A
A
Y
L
E
P
Q
A
Q
L
F
C
S
F
-
L
D
A
E
T
V
A
R
-----
A
R
A
G
---
G
L
F
Q
P
L
L
R
A
V
L
A
H
L
G
Q
A
P
F
Q
E
F
L
D
S
L
Y
F
L
R
F
L
Q
W
K
W
L
E
A
Q
-
P
M
G
E
D
W
F
L
D
F
R
V
L
G
R
G
G
F
G
E
V
F
A
C
Q
M
---
K
---
A
---
T
G
K
L
Y
A
C
K
K
L
N
K
K
R
L
-
K
K
R
K
G
-
Y
Q
G
A
M
V
-
E
K
K
I
L
A
K
V
H
S
---
R
F
I
V
S
L
A
Y
A
F
E
T
K
T
D
L
C
L
V
M
T
I
M
N
G
G
D
I
R
---
Y
H
I
YNVD
E
D
N
P
----
G
--
F
Q
E
P
R
A
I
F
Y
T
A
Q
I
V
S
G
L
E
H
L
H
Q
-
R
N
I
I
Y
R
D
L
K
P
E
N
V
L
L
D
D
D
G
N
V
R
I
S
D
L
G
L
---
A
V
E
L
K
A
G
---
Q
--
T
-
K
-
T
-
K
-
G
Y
A
--
G
T
P
G
F
M
A
P
E
-
L
L
L
-
G
E
E
Y
D
F
S
V
D
Y
F
A
L
G
V
T
L
Y
E
M
I
A
A
R
G
P
F
R
A
R
G
E
K
V
E
--
N
-
K
-
E
L
K
Q
R
V
L
E
Q
A
V
T
Y
P
D
K
F
S
P
A
S
K
D
F
C
E
A
L
L
Q
K
D
P
E
K
R
L
G
F
R
-
D
-
G
S
C
D
G
L
R
T
H
P
L
F
R
D
I
S
W
R
Q
L
E
A
G
M
L
T
P
P
F
V
P
D
S
R
-------------
S
T
--
V
-
K
G
V
A
F
---------
E
K
A
--------
D
T
E
F
F
Q
E
F
A
-
S
G
T
C
P
I
P
W
Q
E
E
M
I
E
T
-
G
-
V
F
G
D
L
N
V
W
R
P
---------------------------------------------------------------------------------------------------------------------------------------------------------
37
PsiBlast_CBE
65.39
34%
-90
- C1 -
3C4W
1
RK_BOVIN
B:
[9-522]
------
V
V
A
N
S
A
F
I
A
A
R
G
S
F
D
A
S
SG
P
A
S
R
D
R
---
K
Y
L
A
R
----
L
K
L
P
P
L
S
K
C
E
A
L
R
E
S
L
-----
D
L
G
F
E
G
M
C
L
-
E
Q
P
I
G
K
R
L
F
Q
Q
F
-
L
R
T
H
E
Q
H
G
P
A
----
L
Q
----
L
W
K
D
I
E
D
Y
D
T
A
D
D
A
L
-
R
P
Q
K
A
Q
A
L
R
A
A
Y
L
E
P
Q
A
Q
L
F
C
S
F
L
D
A
E
T
V
A
R
------
A
R
A
--
G
D
G
L
F
Q
P
L
L
R
A
V
L
A
H
L
G
Q
A
P
F
Q
E
F
L
D
S
L
Y
F
L
R
F
L
Q
W
K
W
L
E
A
Q
-
P
M
G
E
D
W
F
L
D
F
R
V
L
G
R
G
G
F
G
E
V
F
A
C
Q
M
---
K
---
A
---
T
G
K
L
Y
A
C
K
K
L
N
K
K
R
L
-
K
K
R
K
G
-
Y
Q
G
A
M
V
-
E
K
K
I
L
A
K
V
H
S
---
R
F
I
V
S
L
A
Y
A
F
E
T
K
T
D
L
C
L
V
M
T
I
M
N
G
G
D
I
R
---
Y
H
I
Y
N
V
D
E
D
N
P
----
G
--
F
Q
E
P
R
A
I
F
Y
T
A
Q
I
V
S
G
L
E
H
L
H
Q
-
R
N
I
I
Y
R
D
L
K
P
E
N
V
L
L
D
D
D
G
N
V
R
I
S
D
L
G
L
---
A
V
E
L
K
A
G
---
Q
--
T
-
K
-
T
-
K
-
G
Y
A
--
G
T
P
G
F
M
A
P
E
-
L
L
L
-
G
E
E
Y
D
F
S
V
D
Y
F
A
L
G
V
T
L
Y
E
M
I
A
A
R
G
P
F
R
A
R
G
E
K
V
E
--
N
-
K
-
E
L
K
Q
R
V
L
E
Q
A
V
T
Y
P
D
K
F
S
P
A
S
K
D
F
C
E
A
L
L
Q
K
D
P
E
K
R
L
G
F
R
-
D
-
G
S
C
D
G
L
R
T
H
P
L
F
R
D
I
S
W
R
Q
L
E
A
G
M
L
T
P
P
F
V
P
D
S
R
T
V
Y
A
K
N
--------
T
--
V
-
K
G
V
A
F
---------
E
K
A
--------
D
T
E
F
F
Q
E
F
A
-
S
G
T
C
P
I
P
W
Q
E
E
M
I
E
T
-
G
-
V
F
G
D
L
N
V
W
R
P
---------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
65.36
38%
-101
- C1 -
4WNK
1
GRK5_BOVIN
A:
[60-518]
---------------------------------------------------------------------------
Q
P
V
G
R
L
L
F
R
Q
F
C
-----
E
T
R
P
G
L
E
S
Y
I
Q
----
F
L
D
S
V
A
E
Y
E
-
V
T
P
D
E
K
L
G
E
K
G
K
E
I
M
T
K
Y
L
T
P
K
S
-
P
V
F
I
T
Q
V
G
R
D
L
V
S
Q
T
E
E
K
L
L
Q
K
P
C
K
E
-
L
F
S
A
C
V
Q
S
V
H
D
Y
L
R
G
E
P
F
H
E
Y
L
D
S
M
Y
F
D
R
F
L
Q
W
K
W
L
E
R
Q
-
P
V
T
K
N
T
F
R
Q
Y
R
V
L
G
K
G
G
F
G
E
V
C
A
C
Q
V
---
R
---
A
---
T
G
K
M
Y
A
C
K
R
L
E
K
K
R
I
-
K
K
R
K
G
-
E
S
M
A
L
N
-
E
K
Q
I
L
E
K
V
N
S
R
---
F
V
V
N
L
A
Y
A
Y
E
T
K
D
A
L
C
L
V
L
T
I
M
N
G
G
D
L
K
---
F
H
I
----
Y
N
M
G
----
N
PG
F
E
E
E
R
A
L
F
Y
A
A
E
I
L
C
G
L
E
D
L
H
H
-
E
N
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
D
Y
G
H
I
R
I
S
D
L
G
L
---
A
V
K
I
--
P
---
E
--
G
-
D
L
I
-
R
-
G
R
V
--
G
T
V
G
Y
M
A
P
E
-
V
L
N
-
N
Q
R
Y
G
L
S
P
D
Y
W
G
L
G
C
L
I
Y
E
M
I
E
G
Q
S
P
F
R
G
R
K
E
K
-
V
--
K
-
R
E
E
V
D
R
R
V
L
E
T
E
E
V
Y
S
H
K
F
S
E
E
A
K
S
I
C
K
M
L
L
T
K
D
A
K
Q
R
L
G
C
Q
-
E
-
E
G
A
A
E
V
K
R
H
P
F
F
R
N
M
N
F
K
R
L
E
A
G
M
L
D
P
P
F
V
P
D
P
R
A
V
Y
-------------------------------
H
T
--------
D
D
D
F
Y
S
K
F
S
-
T
G
S
V
P
I
P
W
Q
S
E
M
I
E
T
-
E
-
C
F
K
E
L
N
V
F
G
P
H
G
T
L
S
P
D
L
N
R
S
H
---------------------------------------------------------------------------------------------------------------------------------------------
88
Fugue
65.35
34%
-87
- C1 -
3C4Z
1
RK_BOVIN
A:
[31-533]
-------------------------
R
D
R
K
Y
L
---
A
---
R
----
L
K
L
P
P
----
L
S
K
C
E
A
L
R
-
E
S
L
D
L
G
F
E
G
M
-
C
L
E
Q
P
I
G
K
R
L
F
Q
Q
F
L
R
T
H
-
E
Q
H
G
P
A
----
L
Q
----
L
W
K
D
I
E
D
Y
D
T
A
D
-
D
A
L
R
P
Q
K
A
Q
A
L
R
A
A
Y
L
E
P
Q
---------
A
Q
L
F
C
S
F
L
D
A
E
T
V
A
R
A
R
A
G
G
L
F
Q
P
L
L
R
A
V
L
A
H
L
G
Q
A
P
F
Q
E
F
L
D
S
L
Y
F
L
R
F
L
Q
W
K
W
L
E
A
Q
-
P
M
G
E
D
W
F
L
D
F
R
V
L
G
R
G
G
F
G
E
V
F
A
C
Q
M
---
K
---
A
---
T
G
K
L
Y
A
C
K
K
L
N
K
K
R
L
-
K
K
R
K
G
-
Y
Q
G
A
M
V
-
E
K
K
I
L
A
K
V
H
S
---
R
F
I
V
S
L
A
Y
A
F
E
T
K
T
D
L
C
L
V
M
T
I
M
N
G
G
D
I
R
---
Y
H
I
YNVD
E
D
N
P
----
G
--
F
Q
E
P
R
A
I
F
Y
T
A
Q
I
V
S
G
L
E
H
L
H
Q
-
R
N
I
I
Y
R
D
L
K
P
E
N
V
L
L
D
D
D
G
N
V
R
I
S
D
L
G
L
---
A
V
E
L
--
K
AG-
Q
--
T
-
K
-
T
-
K
-
G
Y
A
--
G
T
P
G
F
M
A
P
E
-
L
L
-
L
G
E
E
Y
D
F
S
V
D
Y
F
A
L
G
V
T
L
Y
E
M
I
A
A
R
G
P
F
R
A
R
G
E
K
V
E
--
N
-
K
-
E
L
K
Q
R
V
L
E
Q
A
V
T
Y
P
D
K
F
S
P
A
S
K
D
F
C
E
A
L
L
Q
K
D
P
E
K
R
L
G
F
R
-
D
-
G
S
C
D
G
L
R
T
H
P
L
F
R
D
I
S
W
R
Q
L
E
A
G
M
L
T
P
P
F
V
P
D
S
R
T
V
Y
A
K
N
---------
G
A
F
-
S
G
V
A
F
---------
E
K
A
--------
D
T
E
F
F
Q
E
F
A
-
S
G
T
C
P
I
P
W
Q
E
E
M
I
E
T
G
V
-
F
G
D
L
N
V
W
R
P
----------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
64.46
38%
-85
- C1 -
2ACX
1
GRK6_HUMAN
A:
[14-518]
--------------
K
A
R
---------
K
G
K
S
K
---
K
W
--
R
----
Q
M
L
Q
F
P
H
I
S
Q
C
E
E
L
R
L
S
L
E
R
D
Y
H
S
L
C
E
----
R
N
P
I
G
R
L
L
F
R
E
F
C
A
T
R
-
P
E
L
S
R
C
----
V
A
----
F
L
D
G
V
A
E
Y
E
V
T
P
D
D
K
R
K
A
C
-
G
R
N
L
T
Q
N
F
L
S
H
T
G
-
P
D
L
I
P
E
V
P
R
Q
L
V
T
N
C
T
Q
R
L
E
Q
G
P
C
K
D
-
L
F
Q
E
L
T
R
L
T
H
E
Y
L
S
V
A
P
F
A
D
Y
L
D
S
I
Y
F
N
R
F
L
Q
W
K
W
L
E
R
Q
-
P
V
T
K
N
T
F
R
Q
Y
R
V
L
G
K
G
G
F
G
E
V
C
A
C
Q
V
---
R
---
A
---
T
G
K
M
Y
A
C
K
K
L
E
K
K
R
I
-
K
K
R
K
G
-
E
A
M
A
L
N
-
E
K
Q
I
L
E
K
V
N
S
R
---
F
V
V
S
L
A
Y
A
Y
E
T
K
D
A
L
C
L
V
L
T
L
M
N
G
G
D
L
K
F
H
I
Y
H
M
----
G
Q
A
G
-------
F
P
E
A
R
A
V
F
Y
A
A
E
I
C
C
G
L
E
D
L
H
R
-
E
R
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
D
H
G
H
I
R
I
S
D
L
G
L
---
A
V
H
V
--
P
---
E
--
G
-
Q
-
T
I
K
-
G
R
V
--
G
T
V
G
Y
M
A
P
E
-
V
V
-
K
N
E
R
Y
T
F
S
P
D
W
W
A
L
G
C
L
L
Y
E
M
I
A
G
Q
S
P
F
Q
Q
R
K
K
K
-
I
--
K
-
R
E
E
V
E
R
L
V
K
E
V
P
E
E
Y
S
E
R
F
S
P
Q
A
R
S
L
C
S
Q
L
L
C
K
D
P
A
E
R
L
G
C
R
-
G
-
G
S
A
R
E
V
K
E
H
P
L
F
K
K
L
N
F
K
R
L
G
A
G
M
L
E
P
P
F
K
P
D
P
Q
A
I
Y
C
-----------------------------
E
P
T
--------
D
Q
D
F
Y
Q
K
F
A
-
T
G
S
V
P
I
P
W
Q
N
E
M
V
E
T
-
E
-
C
F
Q
E
L
N
V
F
G
L
D
G
S
------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
64.06
39%
-94
- C1 -
4TND
1
GRK5_HUMAN
A:
[60-518]
---------------------------------------------------------------------------
Q
P
I
G
R
L
L
F
R
Q
F
C
-----
E
T
R
P
G
L
E
C
Y
I
Q
----
F
L
D
S
V
A
E
Y
E
-
V
T
P
D
E
K
L
G
E
K
G
K
K
I
M
T
K
Y
L
T
P
K
S
-
P
V
F
I
A
Q
V
G
Q
D
L
V
S
Q
T
E
E
K
L
L
Q
K
P
C
K
E
-
L
F
S
A
C
A
Q
S
V
H
E
Y
L
R
G
E
P
F
H
E
Y
L
D
S
M
F
F
D
R
F
L
Q
W
K
W
L
E
R
Q
-
P
V
T
K
N
T
F
R
Q
Y
R
V
L
G
K
G
G
F
G
E
V
C
A
C
Q
V
---
R
---
A
---
T
G
K
M
Y
A
C
K
R
L
E
K
K
R
I
-
K
K
R
K
G
-
E
S
M
A
L
N
-
E
K
Q
I
L
E
K
V
N
S
Q
---
F
V
V
N
L
A
Y
A
Y
E
T
K
D
A
L
C
L
V
L
T
I
M
N
G
G
D
L
K
---
F
H
I
----
Y
N
M
G
----
N
PG
F
E
E
E
R
A
L
F
Y
A
A
E
I
L
C
G
L
E
D
L
H
H
-
E
N
T
V
Y
R
D
L
K
P
E
N
I
L
L
D
D
Y
G
H
I
R
I
S
D
L
G
L
---
A
V
K
I
--
P
---
E
--
G
-
D
L
I
-
R
-
G
R
V
--
G
T
V
G
Y
M
A
P
E
-
V
L
N
-
N
Q
R
Y
G
L
S
P
D
Y
W
G
L
G
C
L
I
Y
E
M
I
E
G
Q
S
P
F
R
G
R
K
E
K
-
V
--
K
-
R
E
E
V
D
R
R
V
L
E
T
E
E
V
Y
S
H
K
F
S
E
E
A
K
S
I
C
K
M
L
L
T
K
D
A
K
Q
R
L
G
C
Q
-
E
-
E
E
A
A
E
V
K
R
H
P
F
F
R
N
M
N
F
K
R
L
E
A
G
M
L
D
P
P
F
V
P
D
P
R
A
V
Y
C
K
D
V
L
D
I
E
Q
F
S
--
T
V
-
K
G
V
N
L
---------
D
H
T
--------
D
D
D
F
Y
S
K
F
S
-
T
G
S
V
S
I
P
W
Q
N
E
M
I
E
T
-
E
-
C
F
K
E
L
N
V
F
G
P
N
G
T
L
P
P
D
L
N
R
N
H
P
P
-------------------------------------------------------------------------------------------------------------------------------------------
23
PsiBlast_CBE
64.05
38%
-84
- C1 -
2ACX
1
GRK6_HUMAN
B:
[14-518]
--------------
K
A
R
---------
K
G
K
S
K
---
K
W
--
R
----
Q
M
L
Q
F
P
H
I
S
Q
C
E
E
L
R
L
S
L
E
R
D
Y
H
S
L
C
E
----
R
N
P
I
G
R
L
L
F
R
E
F
C
A
T
R
-
P
E
L
S
R
C
----
V
A
----
F
L
D
G
V
A
E
Y
E
V
T
P
D
D
K
R
K
A
C
-
G
R
N
L
T
Q
N
F
L
S
H
T
G
-
P
D
L
I
P
E
V
P
R
Q
L
V
T
N
C
T
Q
R
L
E
Q
G
P
C
K
D
-
L
F
Q
E
L
T
R
L
T
H
E
Y
L
S
V
A
P
F
A
D
Y
L
D
S
I
Y
F
N
R
F
L
Q
W
K
W
L
E
R
Q
-
P
V
T
K
N
T
F
R
Q
Y
R
V
L
G
K
G
G
F
G
E
V
C
A
C
Q
V
---
R
---
A
---
T
G
K
M
Y
A
C
K
K
L
E
K
K
R
I
-
K
K
R
K
G
-
E
A
M
A
L
N
-
E
K
Q
I
L
E
K
V
N
S
R
---
F
V
V
S
L
A
Y
A
Y
E
T
K
D
A
L
C
L
V
L
T
L
M
N
G
G
D
L
K
F
H
I
Y
H
M
------
A
G
-------
F
P
E
A
R
A
V
F
Y
A
A
E
I
C
C
G
L
E
D
L
H
R
-
E
R
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
D
H
G
H
I
R
I
S
D
L
G
L
---
A
V
H
V
--
P
---
E
--
G
-
Q
-
T
I
K
-
G
R
V
--
G
T
V
G
Y
M
A
P
E
-
V
V
-
K
N
E
R
Y
T
F
S
P
D
W
W
A
L
G
C
L
L
Y
E
M
I
A
G
Q
S
P
F
Q
Q
---
K
-
I
--
K
-
R
E
E
V
E
R
L
V
K
E
V
P
E
E
Y
S
E
R
F
S
P
Q
A
R
S
L
C
S
Q
L
L
C
K
D
P
A
E
R
L
G
C
R
-
G
-
G
S
A
R
E
V
K
E
H
P
L
F
K
K
L
N
F
K
R
L
G
A
G
M
L
E
P
P
F
K
P
D
P
Q
A
I
Y
------------------------------
E
P
T
--------
D
Q
D
F
Y
Q
K
F
A
-
T
G
S
V
P
I
P
W
Q
N
E
M
V
E
T
-
E
-
C
F
Q
E
L
N
V
F
G
L
D
G
S
V
P
P
---------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
63.94
39%
-92
- C1 -
4TNB
1
GRK5_HUMAN
A:
[60-518]
---------------------------------------------------------------------------
Q
P
I
G
R
L
L
F
R
Q
F
C
-----
E
T
R
P
G
L
E
C
Y
I
Q
----
F
L
D
S
V
A
E
Y
E
-
V
T
P
D
E
K
L
G
E
K
G
K
K
I
M
T
K
Y
L
T
P
K
S
-
P
V
F
I
A
Q
V
G
Q
D
L
V
S
Q
T
E
E
K
L
L
Q
K
P
C
K
E
-
L
F
S
A
C
A
Q
S
V
H
E
Y
L
R
G
E
P
F
H
E
Y
L
D
S
M
F
F
D
R
F
L
Q
W
K
W
L
E
R
Q
-
P
V
T
K
N
T
F
R
Q
Y
R
V
L
G
K
G
G
F
G
E
V
C
A
C
Q
V
---
R
---
A
---
T
G
K
M
Y
A
C
K
R
L
E
K
K
R
I
-
K
K
R
K
G
-
E
S
M
A
L
N
-
E
K
Q
I
L
E
K
V
N
S
Q
---
F
V
V
N
L
A
Y
A
Y
E
T
K
D
A
L
C
L
V
L
T
I
M
N
G
G
D
L
K
---
F
H
I
----
Y
N
M
G
----
N
PG
F
E
E
E
R
A
L
F
Y
A
A
E
I
L
C
G
L
E
D
L
H
H
-
E
N
T
V
Y
R
D
L
K
P
E
N
I
L
L
D
D
Y
G
H
I
R
I
S
D
L
G
L
---
A
V
K
I
--
P
---
E
--
G
-
D
L
I
-
R
-
G
R
V
--
G
T
V
G
Y
M
A
P
E
-
V
L
N
-
N
Q
R
Y
G
L
S
P
D
Y
W
G
L
G
C
L
I
Y
E
M
I
E
G
Q
S
P
F
R
G
R
K
E
K
-
V
--
K
-
R
E
E
V
D
R
R
V
L
E
T
E
E
V
Y
S
H
K
F
S
E
E
A
K
S
I
C
K
M
L
L
T
K
D
A
K
Q
R
L
G
C
Q
-
E
-
E
E
A
A
E
V
K
R
H
P
F
F
R
N
M
N
F
K
R
L
E
A
G
M
L
D
P
P
F
V
P
D
P
R
A
V
Y
C
K
D
V
L
D
I
E
Q
F
S
--
T
V
-
K
G
V
N
L
---------
D
H
T
--------
D
D
D
F
Y
S
K
F
S
-
T
G
S
V
S
I
P
W
Q
N
E
M
I
E
T
-
E
-
C
F
K
E
L
N
V
F
G
P
N
G
T
L
P
P
D
L
N
R
N
H
P
P
-------------------------------------------------------------------------------------------------------------------------------------------
39
PsiBlast_CBE
63.33
35%
-94
- C1 -
4L9I
2
RK_BOVIN
A:
[21-493]
----------------------------------------------------------
L
R
-
E
S
L
D
L
G
F
E
G
M
C
L
-
E
Q
P
I
G
K
R
L
F
Q
Q
F
-
L
R
T
H
E
Q
H
G
P
A
----
L
Q
----
L
W
K
D
I
E
D
Y
D
T
A
D
D
A
L
-
R
P
Q
K
A
Q
A
L
R
A
A
Y
L
E
P
Q
A
Q
L
F
C
S
F
L
D
A
E
T
V
A
R
------
A
R
A
G
A
G
D
G
L
F
Q
P
L
L
R
A
V
L
A
H
L
G
Q
A
P
F
Q
E
F
L
D
S
L
Y
F
L
R
F
L
Q
W
K
W
L
E
A
Q
-
P
M
G
E
D
W
F
L
D
F
R
V
L
G
R
G
G
F
G
E
V
F
A
C
Q
M
---
K
---
A
---
T
G
K
L
Y
A
C
K
K
L
N
K
K
R
L
-
K
K
R
K
G
-
Y
Q
G
A
M
V
-
E
K
K
I
L
A
K
V
H
S
---
R
F
I
V
S
L
A
Y
A
F
E
T
K
T
D
L
C
L
V
M
T
I
M
N
G
G
D
I
R
---
Y
H
I
YNVD
E
D
N
P
----
G
--
F
Q
E
P
R
A
I
F
Y
T
A
Q
I
V
S
G
L
E
H
L
H
Q
-
R
N
I
I
Y
R
D
L
K
P
E
N
V
L
L
D
D
D
G
N
V
R
I
S
D
L
G
L
---
A
V
E
L
K
A
G
---
Q
--
T
-
K
-
T
-
K
-
G
Y
A
--
G
T
P
G
F
M
A
P
E
-
L
L
L
-
G
E
E
Y
D
F
S
V
D
Y
F
A
L
G
V
T
L
Y
E
M
I
A
A
R
G
P
F
R
A
R
G
E
K
V
E
--
N
-
K
-
E
L
K
Q
R
V
L
E
Q
A
V
T
Y
P
D
K
F
S
P
A
S
K
D
F
C
E
A
L
L
Q
K
D
P
E
K
R
L
G
F
R
-
D
-
G
S
C
D
G
L
R
T
H
P
L
F
R
D
I
S
W
R
Q
L
E
A
G
M
L
T
P
P
F
V
P
D
S
R
T
V
Y
A
K
N
I
Q
D
V
G
A
F
S
T
--
V
-
K
G
V
A
F
---------
E
K
A
--------
D
T
E
F
F
Q
E
F
A
-
S
G
T
C
P
I
P
W
Q
E
E
M
I
E
T
-
G
-
V
F
G
D
L
N
V
W
R
P
---------------------------------------------------------------------------------------------------------------------------------------------------------
100
HHSearch
53.79
40%
-96
- C1 -
4GV1
5
AKT1_HUMAN
A:
[3-304]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
R
V
T
M
N
E
F
E
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
K
E
---
K
---
A
---
T
G
R
Y
Y
A
M
K
I
L
K
K
E
V
I
-
V
A
K
D
E
-
V
A
H
T
L
T
-
E
N
R
V
L
Q
N
S
---
R
H
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
---
F
H
L
----
S
R
E
R
----
V
--
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
K
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
K
D
G
H
I
K
I
T
D
F
G
L
---
C
K
E
G
--
I
---
K
DG
A
-
T
-
M
-
K
-
T
F
C
--
G
T
P
E
Y
L
A
P
E
-
V
L
E
-
D
N
D
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
Y
N
---
Q
-
D
--
H
-
E
-
K
L
F
E
L
I
L
M
E
E
I
R
F
P
R
T
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
R
L
G
G
G
-
S
-
E
D
A
K
E
I
M
Q
H
R
F
F
A
G
I
V
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
P
Q
V
-----
T
S
E
T
D
T
R
Y
F
D
E
E
F
T
-
A
Q
M
I
T
---------
I
T
P
--------
S
M
E
C
V
D
S
E
R
-
R
-
P
H
F
P
Q
F
D
Y
S
A
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------
108
HHSearch
53.33
31%
-97
- C1 -
4DC2
1
KPCI_MOUSE
A:
[49-385]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
L
Q
D
F
D
L
L
R
V
I
G
R
G
S
Y
A
K
V
L
L
V
R
L
---
K
---
K
---
T
D
R
I
Y
A
M
R
V
V
K
K
E
L
V
-
N
-----
I
D
W
V
Q
T
-
E
K
H
V
F
E
Q
A
--
S
N
H
P
F
L
V
G
L
H
S
C
F
Q
T
E
S
R
L
F
F
V
I
E
Y
V
N
G
G
D
L
M
---
F
H
M
----
Q
R
Q
R
----
K
--
L
P
E
E
H
A
R
F
Y
S
A
E
I
S
L
A
L
N
Y
L
H
E
-
R
G
I
I
Y
R
D
L
K
L
D
N
V
L
L
D
S
E
G
H
I
K
L
T
D
Y
G
M
---
C
K
E
G
--
L
---
R
PG
D
-
T
-
T
-
S
-
T
F
C
--
G
T
P
N
Y
I
A
P
E
-
I
L
R
-
G
E
D
Y
G
F
S
V
D
W
W
A
L
G
V
L
M
F
E
M
M
A
G
R
S
P
F
D
I
V
G
S
---NT
E
-
D
-
Y
L
F
Q
V
I
L
E
K
Q
I
R
I
P
R
S
L
S
V
K
A
A
S
V
L
K
S
F
L
N
K
D
P
K
E
R
L
G
C
H
P
Q
-
T
G
F
A
D
I
Q
G
H
P
F
F
R
N
V
D
W
D
M
M
E
Q
K
Q
V
V
P
P
F
K
P
N
I
-----
S
G
E
F
G
L
D
N
F
D
S
Q
F
T
N
E
P
V
Q
L
---------
T
P
D
D
D
D
I
V
R
KI
D
Q
S
E
F
E
G
F
E
-
Y
-
I
N
P
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
114
HHSearch
52.59
40%
-98
- C1 -
4EJN
3
AKT1_HUMAN
A:
[144-438]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
V
T
M
N
E
F
E
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
K
E
---
K
---
A
---
T
G
R
Y
Y
A
M
K
I
L
K
K
E
V
I
-
V
---------------
V
L
Q
N
---
S
R
H
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
---
F
H
L
----
S
R
E
R
----
V
--
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
K
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
K
D
G
H
I
K
I
T
D
F
G
L
---
C
K
E
G
--
I
---
K
--------
K
-
T
F
C
--
G
T
P
E
Y
L
A
P
E
-
V
L
E
-
D
N
D
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
Y
N
---
Q
-
D
--
H
-
E
-
K
L
F
E
L
I
L
M
E
E
I
R
F
P
R
T
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
R
L
G
G
G
-
S
-
E
D
A
K
E
I
M
Q
H
R
F
F
A
G
I
V
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
P
Q
V
-----
T
S
E
T
D
T
R
Y
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
47
PsiBlast_CBE
52.00
38%
-94
- C1 -
4NW5
1
KS6A3_HUMAN
A:
[30-322]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
Q
F
E
L
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
V
K
K
ISG
S
---
D
---
A
R
Q
L
Y
A
M
K
V
L
K
K
A
T
L
-
K
V
R
D
R
-
V
R
T
K
M
E
-
R
D
I
L
V
E
V
----
N
H
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
---
T
R
L
----
S
K
E
V
----
M
--
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
S
-
L
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
G
H
I
K
L
T
D
F
G
L
---
S
K
E
S
ID
H
---
E
--
K
-
K
-
A
-
Y
-
S
F
C
--
G
T
V
E
Y
M
A
P
E
-
V
V
N
R
-
R
G
H
T
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
T
L
P
F
---
Q
G
K
-
D
--
R
-
K
-
E
T
M
T
M
I
L
K
A
K
L
G
M
P
Q
F
L
S
P
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
R
L
G
A
G
-
P
-
D
G
V
E
E
I
K
R
H
S
F
F
S
T
I
D
W
N
K
L
Y
R
R
E
I
H
P
P
F
K
P
-------
T
F
Y
F
D
P
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
46
PsiBlast_CBE
51.95
38%
-92
- C1 -
4NW6
1
KS6A3_HUMAN
A:
[30-322]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
Q
F
E
L
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
V
K
K
I
S
G
S
---
D
---
A
R
Q
L
Y
A
M
K
V
L
K
K
A
T
L
-
K
V
R
D
R
-
V
R
T
K
M
E
-
R
D
I
L
V
E
V
----
N
H
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
---
T
R
L
----
S
K
E
V
----
M
--
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
S
-
L
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
G
H
I
K
L
T
D
F
G
L
---
S
K
E
S
ID
H
---
E
--
K
-
K
-
A
-
Y
-
S
F
C
--
G
T
V
E
Y
M
A
P
E
-
V
V
N
R
-
R
G
H
T
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
T
L
P
F
---
Q
G
K
-
D
--
R
-
K
-
E
T
M
T
M
I
L
K
A
K
L
G
M
P
Q
F
L
S
P
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
R
L
G
A
G
-
P
-
D
G
V
E
E
I
K
R
H
S
F
F
S
T
I
D
W
N
K
L
Y
R
R
E
I
H
P
P
F
K
P
-------
T
F
Y
F
D
P
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
59
PsiBlast_CBE
51.59
35%
-97
- C1 -
4L42
1
KS6B1_HUMAN
A:
[20-343]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
L
L
R
V
L
G
K
G
G
Y
G
K
V
F
Q
V
R
K
VTG
A
---
N
---
T
G
K
I
F
A
M
K
V
L
K
K
A
M
I
-
V
R
N
A
K
-
D
T
A
H
T
K
A
E
R
N
I
L
E
E
V
K
H
---
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
---
M
Q
L
----
E
R
E
G
----
I
--
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
-
K
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
H
Q
G
H
V
K
L
T
D
F
G
L
----
C
K
E
--
S
IHD
G
--
T
-
V
-
T
-
H
-
T
F
C
--
G
T
I
E
Y
M
A
P
E
-
I
L
M
R
-
S
G
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
P
P
F
T
G
E
N
R
K
-
K
--
T
----
I
D
K
I
-
L
K
C
K
L
N
L
P
P
Y
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
R
L
G
A
G
-
P
-
G
D
A
G
E
V
Q
A
H
P
F
F
R
H
I
N
W
E
E
L
L
A
R
K
V
E
P
P
F
K
--------------------------------------------------
E
M
F
R
D
F
E
-
Y
-
I
A
D
W
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
48
PsiBlast_CBE
51.59
38%
-98
- C1 -
4NUS
1
KS6A3_HUMAN
A:
[30-322]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
Q
F
E
L
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
V
K
K
ISG
S
---
D
---
A
R
Q
L
Y
A
M
K
V
L
K
K
A
T
L
-
K
V
R
D
R
-
V
R
T
K
M
E
-
R
D
I
L
V
E
V
----
N
H
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
---
T
R
L
----
S
K
E
V
----
M
--
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
S
-
L
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
G
H
I
K
L
T
D
F
G
L
---
S
K
E
S
I
D
H
---
E
--
K
-
K
-
A
-
Y
-
S
F
C
--
G
T
V
E
Y
M
A
P
E
-
V
V
N
R
-
R
G
H
T
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
T
L
P
F
---
Q
G
K
-
D
--
R
-
K
-
E
T
M
T
M
I
L
K
A
K
L
G
M
P
Q
F
L
S
P
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
R
L
G
A
G
-
P
-
D
G
V
E
E
I
K
R
H
S
F
F
S
T
I
D
W
N
K
L
Y
R
R
E
I
H
P
P
F
K
P
A
T
------
F
Y
F
D
P
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
42
PsiBlast_CBE
50.97
38%
-102
- C1 -
3G51
1
KS6A3_MOUSE
A:
[24-304]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
Q
F
E
L
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
V
K
K
ISG
S
---
D
---
A
R
Q
L
Y
A
M
K
V
L
K
K
A
T
L
-
K
V
R
-----------
D
I
L
V
E
V
----
N
H
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
---
T
R
L
----
S
K
E
V
----
M
--
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
S
-
L
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
G
H
I
K
L
T
D
F
G
L
---
S
K
E
S
I----------------------
T
V
E
Y
M
A
P
E
-
V
V
N
R
-
R
G
H
T
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
T
L
P
F
---
Q
G
K
-
D
--
R
-
K
-
E
T
M
T
M
I
L
K
A
K
L
G
M
P
Q
F
L
S
P
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
R
L
G
A
G
-
P
-
D
G
V
E
E
I
K
R
H
S
F
F
S
T
I
D
W
N
K
L
Y
R
R
E
I
H
P
P
F
K
P
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
44
PsiBlast_CBE
50.95
38%
-105
- C1 -
5D9K
2
?
A:
[30-322]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
Q
F
E
L
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
V
K
K
ISG
S
---
D
---
A
R
Q
L
Y
A
M
K
V
L
K
K
A
T
L
-
K
V
R
D
R
-
V
R
T
K
M
E
-
R
D
I
L
V
E
V
----
N
H
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
---
T
R
L
----
S
K
E
V
----
M
--
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
S
-
L
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
G
H
I
K
L
T
D
F
G
L
---
S
K
---------------------
C
--
G
T
V
E
Y
M
A
P
E
-
V
V
N
R
-
R
G
H
T
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
T
L
P
F
---
Q
G
K
-
D
--
R
-
K
-
E
T
M
T
M
I
L
K
A
K
L
G
M
P
Q
F
L
S
P
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
R
L
G
A
G
-
P
-
D
G
V
E
E
I
K
R
H
S
F
F
S
T
I
D
W
N
K
L
Y
R
R
E
I
H
P
P
F
K
P
A
T
------
F
Y
F
D
P
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
52
PsiBlast_CBE
50.87
37%
-105
- C1 -
2Z7S
1
KS6A1_HUMAN
A:
[28-308]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
H
F
E
L
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
V
R
K
---
V
TRP
D
---
S
G
H
L
Y
A
M
K
V
L
K
--------------------
I
L
A
D
V
----
N
H
P
F
V
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
---
T
R
L
----
S
K
E
V
----
M
--
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
G
L
D
H
L
H
S
-
L
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
G
H
I
K
L
T
D
F
G
L
SKE--------------------------
G
T
V
E
Y
M
A
P
E
-
V
V
N
R
-
Q
G
H
S
H
S
A
D
W
W
S
Y
G
V
L
M
F
E
M
L
T
G
S
L
P
F
---
Q
G
K
-
D
--
R
-
K
-
E
T
M
T
L
I
L
K
A
K
L
G
M
P
Q
F
L
S
T
E
A
Q
S
L
L
R
A
L
F
K
R
N
P
A
N
R
L
G
S
G
-
P
-
D
G
A
E
E
I
K
R
H
V
F
Y
S
T
I
D
W
N
K
L
Y
R
R
E
I
K
P
P
F
K
P
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
43
PsiBlast_CBE
50.79
38%
-103
- C1 -
5D9K
2
?
B:
[30-322]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
Q
F
E
L
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
V
K
K
ISG
S
---
D
---
A
R
Q
L
Y
A
M
K
V
L
K
K
A
T
L
-
K
V
R
D
R
-
V
R
T
K
M
E
-
R
D
I
L
V
E
V
----
N
H
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
---
T
R
L
----
S
K
E
V
----
M
--
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
S
-
L
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
G
H
I
K
L
T
D
F
G
L
---
S
K
E
--------------------
C
--
G
T
V
E
Y
M
A
P
E
-
V
V
N
R
-
R
G
H
T
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
T
L
P
F
---
Q
G
K
-
D
--
R
-
K
-
E
T
M
T
M
I
L
K
A
K
L
G
M
P
Q
F
L
S
P
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
R
L
G
A
G
-
P
-
D
G
V
E
E
I
K
R
H
S
F
F
S
T
I
D
W
N
K
L
Y
R
R
E
I
H
P
P
F
K
P
-------
T
F
Y
F
D
P
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
73
PsiBlast_CBE
50.75
33%
-90
- C1 -
2F7Z
1
KAPCA_BOVIN
E:
[17-337]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
E
F
L
A
K
A
K
E
D
F
L
K
K
W
E
N
P
A
Q
N
T
-
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
---
M
---
E
---
T
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
K
Q
I
-
E
H
-
T
L
N
-
E
K
R
I
L
Q
A
V
---
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
---
S
H
L
----
R
R
I
G
----
R
--
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
---
A
K
R
V
------
K
--
G
-
R
-
T
-
W
-
T
L
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
--
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
-
Q
--
I
-
Y
-
E
---
K
I
V
S
G
K
V
R
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
L
-
K
-
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
--
D
Y
E
E
E
E
I
-
R
V
S
I
N
---------
E
K
C
--------
G
K
E
F
S
E
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
74
PsiBlast_CBE
50.67
33%
-86
- C1 -
2F7X
1
KAPCA_BOVIN
E:
[17-337]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
E
F
L
A
K
A
K
E
D
F
L
K
K
W
E
N
P
A
Q
N
T
-
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
---
M
---
E
---
T
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
K
Q
I
-
E
H
-
T
L
N
-
E
K
R
I
L
Q
A
V
---
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
---
S
H
L
----
R
R
I
G
----
R
--
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
---
A
K
R
V
------
K
--
G
-
R
-
T
-
W
-
T
L
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
--
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
-
Q
--
I
-
Y
-
E
---
K
I
V
S
G
K
V
R
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
L
-
K
-
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
--
D
Y
E
E
E
E
I
-
R
V
S
I
N
---------
E
K
C
--------
G
K
E
F
S
E
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
53
PsiBlast_CBE
50.33
37%
-102
- C1 -
2Z7R
1
KS6A1_HUMAN
A:
[28-308]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
H
F
E
L
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
V
R
K
---
V
TRP
D
---
S
G
H
L
Y
A
M
K
V
L
K
K
A
T
L
-
K
V
-------------
I
L
A
D
V
----
N
H
P
F
V
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
---
T
R
L
----
S
K
E
V
----
M
--
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
G
L
D
H
L
H
S
-
L
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
G
H
I
K
L
T
D
F
G
L
SKE--------------------------
G
T
V
E
Y
M
A
P
E
-
V
V
N
R
-
Q
G
H
S
H
S
A
D
W
W
S
Y
G
V
L
M
F
E
M
L
T
G
S
L
P
F
---
Q
G
K
-
D
--
R
-
K
-
E
T
M
T
L
I
L
K
A
K
L
G
M
P
Q
F
L
S
T
E
A
Q
S
L
L
R
A
L
F
K
R
N
P
A
N
R
L
G
S
G
-
P
-
D
G
A
E
E
I
K
R
H
V
F
Y
S
T
I
D
W
N
K
L
Y
R
R
E
I
K
P
P
F
K
P
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
71
PsiBlast_CBE
50.32
33%
-85
- C1 -
2OJF
1
KAPCA_BOVIN
E:
[17-337]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
E
F
L
A
K
A
K
E
D
F
L
K
K
W
E
N
P
A
Q
N
T
-
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
---
M
---
E
---
T
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
K
Q
I
-
E
H
-
T
L
N
-
E
K
R
I
L
Q
A
V
---
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
---
S
H
L
----
R
R
I
G
----
R
--
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
---
A
K
R
V
------
K
--
G
-
R
-
T
-
W
-
T
L
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
--
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
-
Q
--
I
-
Y
-
E
---
K
I
V
S
G
K
V
R
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
L
-
K
-
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
--
D
Y
E
E
E
E
I
-
R
V
S
I
N
---------
E
K
C
--------
G
K
E
F
S
E
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
76
PsiBlast_CBE
50.11
33%
-85
- C1 -
2UZW
1
KAPCA_BOVIN
E:
[2-322]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
E
F
L
A
K
A
K
E
D
F
L
K
K
W
E
N
P
A
Q
N
T
-
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
---
M
---
E
---
T
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
K
Q
I
-
E
H
-
T
L
N
-
E
K
R
I
L
Q
A
V
---
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
---
S
H
L
----
R
R
I
G
----
R
--
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
---
A
K
R
---
V
---
K
--
G
-
R
-
T
-
W
-
T
L
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
--
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
-
Q
--
I
-
Y
-
E
---
K
I
V
S
G
K
V
R
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
L
-
K
-
D
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
--
D
Y
E
E
E
E
I
-
R
V
S
I
N
---------
E
K
C
--------
G
K
E
F
S
E
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
40
PsiBlast_CBE
49.93
38%
-95
- C1 -
3O96
1
AKT1_HUMAN
A:
[148-432]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
T
M
N
E
F
E
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
K
E
---
K
---
A
---
T
G
R
Y
Y
A
M
K
I
L
K
K
E
V
I
-
V
A
------------
N
R
V
L
Q
---
N
S
R
H
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
---
F
H
L
----
S
R
E
R
----
V
--
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
K
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
K
D
G
H
I
K
I
T
D
F
G
L
---
C
K
E
-------------------------
P
E
Y
L
A
P
E
-
V
L
E
D
N
D
-
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
Y
N
---
Q
-
D
--
H
-
E
-
K
L
F
E
L
I
L
M
E
E
I
R
F
P
R
T
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
R
L
G
G
G
-
S
-
E
D
A
K
E
I
M
Q
H
R
F
F
A
G
I
V
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
P
-----
Q
V
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
45
PsiBlast_CBE
49.92
38%
-95
- C1 -
5D9L
2
?
A:
[30-322]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
Q
F
E
L
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
V
K
K
I
S
G
S
---
D
---
A
R
Q
L
Y
A
M
K
V
L
K
K
A
T
L
-
K
V
R
D
R
-
V
R
T
K
M
E
-
R
D
I
L
V
E
V
----
N
H
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
---
T
R
L
----
S
K
E
V
----
M
--
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
S
-
L
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
G
H
I
K
L
T
D
F
G
L
---
S
K
E
-----------------------
G
T
V
E
Y
M
A
P
E
-
V
V
N
R
-
R
G
H
T
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
T
L
P
F
---
Q
G
K
-
D
--
R
-
K
-
E
T
M
T
M
I
L
K
A
K
L
G
M
P
Q
F
L
S
P
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
R
L
G
A
G
-
P
-
D
G
V
E
E
I
K
R
H
S
F
F
S
T
I
D
W
N
K
L
Y
R
R
E
I
H
P
P
F
K
P
A
T
G
R
P
E
D
T
F
Y
F
D
P
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
116
HHSearch
49.83
37%
-98
- C1 -
3WF7
2
KS6B1_HUMAN
A:
[15-304]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
I
R
P
E
C
F
E
L
L
R
V
L
G
K
G
G
Y
G
K
V
F
Q
V
R
K
VTG
A
---
N
---
T
G
K
I
F
A
M
K
V
L
K
K
A
M
I
-
V
R
N
A
K
D
T
A
H
T
K
A
-
E
R
N
I
L
E
E
V
---
K
H
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
---
M
Q
L
----
E
R
E
G
----
I
--
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
-
K
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
H
Q
G
H
V
K
L
T
D
F
G
L
---
C
K
E
S
--
I
HD--------
T
-
H
-
T
F
C
--
G
T
I
E
Y
M
A
P
E
-
I
L
M
-
R
S
G
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
P
P
F
T
G
E
N
R
K
------
K
-
T
I
D
K
I
-
L
K
C
K
L
N
L
P
P
Y
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
R
L
G
A
G
-
P
-
G
D
A
G
E
V
Q
A
H
P
F
F
R
H
I
N
W
E
E
L
L
A
R
K
V
E
P
P
F
K
P
L
L
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
68
PsiBlast_CBE
49.70
38%
-93
- C1 -
4L3J
1
KS6B1_HUMAN
A:
[20-300]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
L
L
R
V
L
G
K
G
G
Y
G
K
V
F
Q
V
R
K
VTG
A
---
N
---
T
G
K
I
F
A
M
K
V
L
K
K
A
M
I
-
V
R
N
A
K
-
D
T
A
H
T
K
A
E
R
N
I
L
E
E
V
K
H
---
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
---
M
Q
L
----
E
R
E
G
----
I
--
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
-
K
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
H
Q
G
H
V
K
L
T
D
F
G
L
----
C
K
E
--
S
IHD
G
--
T
-
V
-
T
-
H
-
T
F
C
--
G
T
I
E
Y
M
A
P
E
-
I
L
M
R
-
S
G
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
P
P
F
T
G
E
N
R
K
-
K
--
T
----
I
D
K
I
-
L
K
C
K
L
N
L
P
P
Y
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
R
L
G
A
G
-
P
-
G
D
A
G
E
V
Q
A
H
P
F
F
R
H
I
N
W
E
E
L
L
A
R
K
V
E
P
P
F
K
P
L
L
Q
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
54
PsiBlast_CBE
49.67
37%
-107
- C1 -
2Z7Q
1
KS6A1_HUMAN
A:
[28-308]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
H
F
E
L
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
V
R
K
---
V
TRP
D
---
S
G
H
L
Y
A
M
K
V
L
---------------------
I
L
A
D
V
----
N
H
P
F
V
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
---
T
R
L
----
S
K
E
V
----
M
--
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
G
L
D
H
L
H
S
-
L
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
G
H
I
K
L
T
D
F
G
L
SKE--------------------------
G
T
V
E
Y
M
A
P
E
-
V
V
N
R
-
Q
G
H
S
H
S
A
D
W
W
S
Y
G
V
L
M
F
E
M
L
T
G
S
L
P
F
---
Q
G
K
-
D
--
R
-
K
-
E
T
M
T
L
I
L
K
A
K
L
G
M
P
Q
F
L
S
T
E
A
Q
S
L
L
R
A
L
F
K
R
N
P
A
N
R
L
G
S
G
-
P
-
D
G
A
E
E
I
K
R
H
V
F
Y
S
T
I
D
W
N
K
L
Y
R
R
E
I
K
P
P
F
K
P
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
102
HHSearch
49.61
32%
-97
- C1 -
3TXO
1
KPCL_HUMAN
A:
[23-347]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
N
F
E
F
I
R
V
L
G
K
G
S
F
G
K
V
M
L
A
R
V
---
K
---
E
---
T
G
D
L
Y
A
V
K
V
L
K
K
D
V
I
-
L
Q
D
D
D
-
V
E
C
T
M
T
-
E
K
R
I
L
S
L
A
--
R
N
H
P
F
L
T
Q
L
F
C
C
F
Q
T
P
D
R
L
F
F
V
M
E
F
V
N
G
G
D
L
M
---
F
H
I
----
Q
K
S
R
----
R
--
F
D
E
A
R
A
R
F
Y
A
A
E
I
I
S
A
L
M
F
L
H
D
-
K
G
I
I
Y
R
D
L
K
L
D
N
V
L
L
D
H
E
G
H
C
K
L
A
D
F
G
M
---
C
K
E
G
--
I
---
C
---------------
G
T
P
D
Y
I
A
P
E
-
I
L
Q
-
E
M
L
Y
G
P
A
V
D
W
W
A
M
G
V
L
L
Y
E
M
L
C
G
H
A
P
F
E
A
E
----
N
--
E
-
D
-
D
L
F
E
A
I
L
N
D
E
V
V
Y
P
T
W
L
H
E
D
A
T
G
I
L
K
S
F
M
T
K
N
P
T
M
R
L
G
S
L
-
T
Q
G
G
E
H
A
I
L
R
H
P
F
F
K
E
I
D
W
A
Q
L
N
H
R
Q
I
E
P
P
F
R
P
R
I
-----
K
S
R
E
D
V
S
N
F
D
P
D
F
I
-
K
E
E
P
V
LTPIDEGHL
P
M
I
--------
N
Q
D
E
F
R
N
F
E
-
Y
-
V
S
P
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
106
HHSearch
49.42
39%
-97
- C1 -
2R5T
1
SGK1_HUMAN
A:
[32-320]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
P
H
A
K
P
S
D
F
H
F
L
K
V
I
G
K
G
S
F
G
K
V
L
L
A
R
H
---
K
---
A
---
E
E
V
F
Y
A
V
K
V
L
Q
K
K
A
I
-
L
---------------
V
L
--
L
K
N
V
K
H
P
F
L
V
G
L
H
F
S
F
Q
T
A
D
K
L
Y
F
V
L
D
Y
I
N
G
G
E
L
F
---
Y
H
L
----
Q
R
E
R
----
C
--
F
L
E
P
R
A
R
F
Y
A
A
E
I
A
S
A
L
G
Y
L
H
S
-
L
N
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
S
Q
G
H
I
V
L
T
D
F
G
L
---
C
K
E
N
--
I
---
E
H
N
S
-
T
-
T
-
S
-
T
F
C
--
G
T
P
E
Y
L
A
P
E
-
V
L
H
-
K
Q
P
Y
D
R
T
V
D
W
W
C
L
G
A
V
L
Y
E
M
L
Y
G
L
P
P
F
Y
S
R
----
N
--
T
-
A
-
E
M
Y
D
N
I
L
N
K
P
L
Q
L
K
P
N
I
T
N
S
A
R
H
L
L
E
G
L
L
Q
K
D
R
T
K
R
L
G
A
--
K
-
D
D
F
M
E
I
K
S
H
V
F
F
S
L
I
N
W
D
D
L
I
N
K
K
I
T
P
P
F
N
P
N
V
S
-----
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
75
PsiBlast_CBE
49.40
33%
-83
- C1 -
2F7E
1
KAPCA_BOVIN
E:
[17-337]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
E
F
L
A
K
A
K
E
D
F
L
K
K
W
E
N
P
A
Q
N
T
-
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
---
M
---
E
---
T
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
K
Q
I
-
E
H
-
T
L
N
-
E
K
R
I
L
Q
A
V
---
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
---
S
H
L
----
R
R
I
G
----
R
--
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
---
A
K
R
V
------
K
--
G
-
R
-
T
-
W
-
T
L
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
--
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
-
Q
--
I
-
Y
-
E
---
K
I
V
S
G
K
V
R
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
L
-
K
-
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
--
D
Y
E
E
E
E
I
-
R
V
S
I
N
---------
E
K
C
--------
G
K
E
F
S
E
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
79
PsiBlast_CBE
48.77
33%
-85
- C1 -
2UZT
1
KAPCA_BOVIN
A:
[2-322]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
E
F
L
A
K
A
K
E
D
F
L
K
K
W
E
N
P
A
Q
N
T
-
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
---
M
---
E
---
T
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
K
Q
I
-
E
H
-
T
L
N
-
E
K
R
I
L
Q
A
V
---
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
---
S
H
L
----
R
R
I
G
----
R
--
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
---
A
K
R
---
V
---
K
--
G
-
R
-
T
-
W
-
T
L
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
--
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
-
Q
--
I
-
Y
-
E
---
K
I
V
S
G
K
V
R
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
L
-
K
-
D
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
--
D
Y
E
E
E
E
I
-
R
V
S
I
N
---------
E
K
C
--------
G
K
E
F
S
E
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
72
PsiBlast_CBE
48.76
33%
-87
- C1 -
2OH0
1
KAPCA_BOVIN
E:
[17-337]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
E
F
L
A
K
A
K
E
D
F
L
K
K
W
E
N
P
A
Q
N
T
-
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
---
M
---
E
---
T
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
K
Q
I
-
E
H
-
T
L
N
-
E
K
R
I
L
Q
A
V
---
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
---
S
H
L
----
R
R
I
G
----
R
--
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
---
A
K
R
V
------
K
--
G
-
R
-
T
-
W
-
T
L
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
--
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
-
Q
--
I
-
Y
-
E
---
K
I
V
S
G
K
V
R
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
L
-
K
-
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
--
D
Y
E
E
E
E
I
-
R
V
S
I
N
---------
E
K
C
--------
G
K
E
F
S
E
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
58
PsiBlast_CBE
48.52
37%
-96
- C1 -
2R5T
1
SGK1_HUMAN
A:
[32-320]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
P
H
A
K
P
S
D
F
H
F
L
K
V
I
G
K
G
S
F
G
K
V
L
L
A
R
H
---
K
---
A
---
E
E
V
F
Y
A
V
K
V
L
Q
K
K
A
I
-
L
---------------
V
L
--
L
K
N
V
K
H
P
F
L
V
G
L
H
F
S
F
Q
T
A
D
K
L
Y
F
V
L
D
Y
I
N
G
G
E
L
F
---
Y
H
L
----
Q
R
E
R
----
C
--
F
L
E
P
R
A
R
F
Y
A
A
E
I
A
S
A
L
G
Y
L
H
S
-
L
N
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
S
Q
G
H
I
V
L
T
D
F
G
L
---
C
K
E
N
--
I
---
E
--
H
-
N
-
S
-
T
-
T
S
T
FC
G
T
P
E
Y
L
A
P
E
-
V
L
H
K
-
Q
P
Y
D
R
T
V
D
W
W
C
L
G
A
V
L
Y
E
M
L
Y
G
L
P
P
F
Y
S
R
N
T
A
-
E
--
M
-
Y
-
D
---
N
I
L
N
K
P
L
Q
L
K
P
N
I
T
N
S
A
R
H
L
L
E
G
L
L
Q
K
D
R
T
K
R
L
G
A
K
---
D
D
F
M
E
I
K
S
H
V
F
F
S
L
I
N
W
D
D
L
I
N
K
K
I
T
P
P
F
N
P
-----
N
V
S
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
67
PsiBlast_CBE
48.15
38%
-92
- C1 -
4L3L
1
KS6B1_HUMAN
A:
[20-300]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
L
L
R
V
L
G
K
G
G
Y
G
K
V
F
Q
V
R
K
VTG
A
---
N
---
T
G
K
I
F
A
M
K
V
L
K
K
A
M
I
-
V
R
N
A
K
-
D
T
A
H
T
K
A
E
R
N
I
L
E
E
V
K
H
---
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
---
M
Q
L
----
E
R
E
G
----
I
--
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
-
K
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
H
Q
G
H
V
K
L
T
D
F
G
L
----
C
K
E
--
S
IHD
G
--
T
-
V
-
T
-
H
-
T
F
C
--
G
T
I
E
Y
M
A
P
E
-
I
L
M
R
-
S
G
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
P
P
F
T
G
E
N
R
K
-
K
--
T
----
I
D
K
I
-
L
K
C
K
L
N
L
P
P
Y
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
R
L
G
A
G
-
P
-
G
D
A
G
E
V
Q
A
H
P
F
F
R
H
I
N
W
E
E
L
L
A
R
K
V
E
P
P
F
K
P
L
L
Q
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
50
PsiBlast_CBE
48.14
38%
-91
- C1 -
4GUE
1
KS6A3_MOUSE
A:
[25-305]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
Q
F
E
L
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
V
K
K
ISG
S
---
D
---
A
R
Q
L
Y
A
M
K
V
L
K
K
A
T
L
-
K
V
R
D
R
-
V
---------
L
V
E
V
----
N
H
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
---
T
R
L
----
S
K
E
V
----
M
--
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
S
-
L
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
G
H
I
K
L
T
D
F
G
L
---
S
K
E
----------
K
-
K
-
A
-
Y
-
S
F
C
--
G
T
V
E
Y
M
A
P
E
-
V
V
N
R
-
R
G
H
T
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
T
L
P
F
---
Q
G
K
-
D
--
R
-
K
-
E
T
M
T
M
I
L
K
A
K
L
G
M
P
Q
F
L
S
P
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
R
L
G
A
G
-
P
-
D
G
V
E
E
I
K
R
H
S
F
F
S
T
I
D
W
N
K
L
Y
R
R
E
I
H
P
P
F
K
P
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
78
PsiBlast_CBE
47.84
33%
-84
- C1 -
2UZU
1
KAPCA_BOVIN
E:
[2-322]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
E
F
L
A
K
A
K
E
D
F
L
K
K
W
E
N
P
A
Q
N
T
-
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
---
M
---
E
---
T
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
K
Q
I
-
E
H
-
T
L
N
-
E
K
R
I
L
Q
A
V
---
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
---
S
H
L
----
R
R
I
G
----
R
--
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
---
A
K
R
---
V
---
K
--
G
-
R
-
T
-
W
-
T
L
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
--
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
-
Q
--
I
-
Y
-
E
---
K
I
V
S
G
K
V
R
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
L
-
K
-
D
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
--
D
Y
E
E
E
E
I
-
R
V
S
I
N
---------
E
K
C
--------
G
K
E
F
S
E
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
64
PsiBlast_CBE
47.68
38%
-97
- C1 -
3A61
1
KS6B1_HUMAN
A:
[19-299]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
L
L
R
V
L
G
K
G
G
Y
G
K
V
F
Q
V
R
K
V
T
G
A
---
N
---
T
G
K
I
F
A
M
K
V
L
K
-----------------A
E
R
N
I
L
E
E
V
K
H
---
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
---
M
Q
L
----
E
R
E
G
----
I
--
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
-
K
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
H
Q
G
H
V
K
L
T
D
F
G
------------------------------
G
T
I
E
Y
M
A
P
E
-
I
L
M
R
-
S
G
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
P
P
F
T
G
E
N
R
K
-
K
--
T
----
I
D
K
I
-
L
K
C
K
L
N
L
P
P
Y
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
R
L
G
A
G
-
P
-
G
D
A
G
E
V
Q
A
H
P
F
F
R
H
I
N
W
E
E
L
L
A
R
K
V
E
P
P
F
K
P
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
118
HHSearch
47.18
40%
-95
- C1 -
3UBD
1
KS6A3_MOUSE
A:
[21-304]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
P
S
Q
F
E
L
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
V
K
K
---
I
---
S
GSD
A
R
Q
L
Y
A
M
K
V
L
K
K
A
T
L
-
K
V
R
D
R
-
V
--------
D
I
L
V
E
---
V
N
H
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
---
T
R
L
----
S
K
E
V
----
M
--
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
S
-
L
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
G
H
I
K
L
T
D
F
G
L
---
S
K
---------E-
K
-
K
-
A
-
Y
-
S
F
C
--
G
T
V
E
Y
M
A
P
E
-
V
V
N
-
R
R
G
H
T
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
T
L
P
F
Q
G
K
----
D
--
R
-
K
-
E
T
M
T
M
I
L
K
A
K
L
G
M
P
Q
F
L
S
P
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
R
L
G
A
G
-
P
-
D
G
V
E
E
I
K
R
H
S
F
F
S
T
I
D
W
N
K
L
Y
R
R
E
I
H
P
P
F
K
P
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
51
PsiBlast_CBE
47.00
38%
-91
- C1 -
4EL9
1
KS6A3_MOUSE
A:
[25-305]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
Q
F
E
L
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
V
K
K
ISG
S
---
D
---
A
R
Q
L
Y
A
M
K
V
L
K
K
A
T
L
-
K
V
R
D
R
-
V
R
------
D
I
L
V
E
V
----
N
H
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
---
T
R
L
----
S
K
E
V
----
M
--
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
S
-
L
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
G
H
I
K
L
T
D
F
G
L
---
S
K
E
S
------
E
--
K
-
K
-
A
-
Y
-
S
F
C
--
G
T
V
E
Y
M
A
P
E
-
V
V
N
R
-
R
G
H
T
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
T
L
P
F
---
Q
G
K
-
D
--
R
-
K
-
E
T
M
T
M
I
L
K
A
K
L
G
M
P
Q
F
L
S
P
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
R
L
G
A
G
-
P
-
D
G
V
E
E
I
K
R
H
S
F
F
S
T
I
D
W
N
K
L
Y
R
R
E
I
H
P
P
F
K
P
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
57
PsiBlast_CBE
46.90
37%
-90
- C1 -
3HDM
1
SGK1_HUMAN
A:
[32-320]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
P
H
A
K
P
S
D
F
H
F
L
K
V
I
G
K
G
S
F
G
K
V
L
L
A
R
H
---
K
---
A
---
E
E
V
F
Y
A
V
K
V
L
Q
K
K
A
I
-
L
---------------
V
L
--
L
K
N
V
K
H
P
F
L
V
G
L
H
F
S
F
Q
T
A
D
K
L
Y
F
V
L
D
Y
I
N
G
G
E
L
F
---
Y
H
L
----
Q
R
E
R
----
C
--
F
L
E
P
R
A
R
F
Y
A
A
E
I
A
S
A
L
G
Y
L
H
S
-
L
N
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
S
Q
G
H
I
V
L
T
D
F
G
L
---
C
K
E
N
--
I
---
E
--
H
-
N
-
S
-
T
-
T
S
T
FC
G
T
P
E
Y
L
A
P
E
-
V
L
H
K
-
Q
P
Y
D
R
T
V
D
W
W
C
L
G
A
V
L
Y
E
M
L
Y
G
L
P
P
F
Y
S
R
N
T
A
-
E
--
M
-
Y
-
D
---
N
I
L
N
K
P
L
Q
L
K
P
N
I
T
N
S
A
R
H
L
L
E
G
L
L
Q
K
D
R
T
K
R
L
G
A
K
---
D
D
F
M
E
I
K
S
H
V
F
F
S
L
I
N
W
D
D
L
I
N
K
K
I
T
P
P
F
N
P
-----
N
V
S
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
49
PsiBlast_CBE
46.81
38%
-92
- C1 -
3UBD
1
KS6A3_MOUSE
A:
[24-304]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
Q
F
E
L
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
V
K
K
ISG
S
---
D
---
A
R
Q
L
Y
A
M
K
V
L
K
K
A
T
L
-
K
V
R
D
R
-
V
-------
D
I
L
V
E
V
----
N
H
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
---
T
R
L
----
S
K
E
V
----
M
--
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
S
-
L
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
G
H
I
K
L
T
D
F
G
L
---
S
K
E
----------
K
-
K
-
A
-
Y
-
S
F
C
--
G
T
V
E
Y
M
A
P
E
-
V
V
N
R
-
R
G
H
T
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
T
L
P
F
---
Q
G
K
-
D
--
R
-
K
-
E
T
M
T
M
I
L
K
A
K
L
G
M
P
Q
F
L
S
P
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
R
L
G
A
G
-
P
-
D
G
V
E
E
I
K
R
H
S
F
F
S
T
I
D
W
N
K
L
Y
R
R
E
I
H
P
P
F
K
P
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
56
PsiBlast_CBE
46.59
37%
-94
- C1 -
3HDN
1
SGK1_HUMAN
A:
[32-316]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
P
H
A
K
P
S
D
F
H
F
L
K
V
I
G
K
G
S
F
G
K
V
L
L
A
R
H
---
K
---
A
---
E
E
V
F
Y
A
V
K
V
L
Q
K
K
A
I
-
L
---------------
V
L
--
L
K
N
V
K
H
P
F
L
V
G
L
H
F
S
F
Q
T
A
D
K
L
Y
F
V
L
D
Y
I
N
G
G
E
L
F
---
Y
H
L
----
Q
R
E
R
----
C
--
F
L
E
P
R
A
R
F
Y
A
A
E
I
A
S
A
L
G
Y
L
H
S
-
L
N
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
S
Q
G
H
I
V
L
T
D
F
G
L
---
C
K
E
N
--
I
---
E
--
H
-
N
-
S
-
T
-
T
S
T
FC
G
T
P
E
Y
L
A
P
E
-
V
L
H
K
-
Q
P
Y
D
R
T
V
D
W
W
C
L
G
A
V
L
Y
E
M
L
Y
G
L
P
P
F
Y
S
R
N
T
A
-
E
--
M
-
Y
-
D
---
N
I
L
N
K
P
L
Q
L
K
P
N
I
T
N
S
A
R
H
L
L
E
G
L
L
Q
K
D
R
T
K
R
L
G
A
K
---
D
D
F
M
E
I
K
S
H
V
F
F
S
L
I
N
W
D
D
L
I
N
K
K
I
T
P
P
F
N
P
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
66
PsiBlast_CBE
45.31
38%
-93
- C1 -
3A60
1
KS6B1_HUMAN
A:
[19-299]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
L
L
R
V
L
G
K
G
G
Y
G
K
V
F
Q
V
R
K
V
T
G
A
---
N
---
T
G
K
I
F
A
M
K
V
L
K
K
A
M
-------------
K
A
E
R
N
I
L
E
E
V
K
H
---
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
---
M
Q
L
----
E
R
E
G
----
I
--
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
-
K
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
H
Q
G
H
V
K
L
T
D
F
G
L
----
C
K
E
-----------------------
T
I
E
Y
M
A
P
E
-
I
L
M
R
-
S
G
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
P
P
F
T
G
E
N
R
K
-
K
--
T
----
I
D
K
I
-
L
K
C
K
L
N
L
P
P
Y
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
R
L
G
A
G
-
P
-
G
D
A
G
E
V
Q
A
H
P
F
F
R
H
I
N
W
E
E
L
L
A
R
K
V
E
P
P
F
K
P
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
69
PsiBlast_CBE
43.87
38%
-92
- C1 -
4RLO
4
KS6B1_HUMAN
B:
[7-287]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
L
L
R
V
L
G
K
G
G
Y
G
K
V
F
Q
V
R
K
VTG
A
---
N
---
T
G
K
I
F
A
M
K
V
L
K
K
-------------------------
K
H
---
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
---
M
Q
L
----
E
R
E
G
----
I
--
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
-
K
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
H
Q
G
H
V
K
L
T
D
F
G
L
----
C
K
E
--
S
I-------------------
T
I
E
Y
M
A
P
E
-
I
L
M
R
-
S
G
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
P
P
F
T
G
E
N
R
K
-
K
--
T
----
I
D
K
I
-
L
K
C
K
L
N
L
P
P
Y
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
R
L
G
A
G
-
P
-
G
D
A
G
E
V
Q
A
H
P
F
F
R
H
I
N
W
E
E
L
L
A
R
K
V
E
P
P
F
K
P
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
65
PsiBlast_CBE
43.41
38%
-87
- C1 -
3A60
1
KS6B1_HUMAN
B:
[19-299]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
L
L
R
V
L
G
K
G
G
Y
G
K
V
F
Q
V
R
K
VTG
A
---
N
---
T
G
K
I
F
A
M
K
V
L
K
K
-------------------------
K
H
---
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
---
M
Q
L
----
E
R
E
G
----
I
--
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
-
K
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
H
Q
G
H
V
K
L
T
D
F
G
L
----
C
K
E
--
S
----------------
C
--
G
T
I
E
Y
M
A
P
E
-
I
L
M
R
-
S
G
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
P
P
F
T
G
E
N
R
K
-
K
--
T
----
I
D
K
I
-
L
K
C
K
L
N
L
P
P
Y
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
R
L
G
A
G
-
P
-
G
D
A
G
E
V
Q
A
H
P
F
F
R
H
I
N
W
E
E
L
L
A
R
K
V
E
P
P
F
K
P
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
31.25
38%
13
- C1 -
3NYN
2
GRK6_HUMAN
A:
[4-518]
--
E
L
E
N
I
V
A
N
T
V
L
L
K
A
R
E
G
G
G
G
N
--
R
K
G
K
S
K
---
K
W
--
R
----
Q
M
L
Q
F
P
H
I
S
Q
C
E
E
L
R
L
S
L
E
R
D
Y
H
S
L
C
E
----
R
Q
P
I
G
R
L
L
F
R
E
F
C
A
T
R
-
P
E
L
S
R
C
----
V
A
----
F
L
D
G
V
A
E
Y
E
V
T
P
D
D
K
R
K
A
C
-
G
R
Q
L
T
Q
N
F
L
S
H
T
G
-
P
D
L
I
P
E
V
P
R
Q
L
V
T
N
C
T
Q
R
L
E
Q
G
P
C
K
D
-
L
F
Q
E
L
T
R
L
T
H
E
Y
L
S
V
A
P
F
A
D
Y
L
D
S
I
Y
F
N
R
F
L
Q
W
K
W
L
E
R
Q
-
P
V
T
K
N
T
F
R
Q
Y
R
V
L
G
K
G
G
F
G
E
V
C
A
C
Q
V
---
R
---
A
---
T
G
K
M
Y
A
C
K
K
L
E
K
K
R
I
-
K
K
R
K
G
-
E
A
M
A
L
N
-
E
K
Q
I
L
E
K
V
N
S
R
---
F
V
V
S
L
A
Y
A
Y
E
T
K
D
A
L
C
L
V
L
T
L
M
N
G
G
D
L
K
F
H
I
Y
H
M
----
G
Q
A
G
-------
F
P
E
A
R
A
V
F
Y
A
A
E
I
C
C
G
L
E
D
L
H
R
-
E
R
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
D
H
G
H
I
R
I
S
D
L
G
L
---
A
V
H
V
--
P
---
E
--
G
-
Q
-
T
I
K
-
G
R
V
--
G
T
V
G
Y
M
A
P
E
-
V
V
-
K
N
E
R
Y
T
F
S
P
D
W
W
A
L
G
C
L
L
Y
E
M
I
A
G
Q
S
P
F
Q
---
K
K
-
I
--
K
-
R
E
E
V
E
R
L
V
K
E
V
P
E
E
Y
S
E
R
F
S
P
Q
A
R
S
L
C
S
Q
L
L
C
K
D
P
A
E
R
L
G
C
R
-
G
-
G
S
A
R
E
V
K
E
H
P
L
F
K
K
L
N
F
K
R
L
G
A
G
M
L
E
P
P
F
K
P
D
P
Q
A
I
Y
C
K
D
V
L
D
I
E
Q
F
S
--
T
V
-
K
G
V
E
L
---------
E
P
T
--------
D
Q
D
F
Y
Q
K
F
A
-
T
G
S
V
P
I
P
W
Q
N
E
M
V
E
T
-
E
-
C
F
Q
E
L
N
V
F
G
L
D
G
S
V
P
P
D
L
D
W
K
G
Q
P
P
A
P
P
K
K
G
L
L
Q
R
L
F
S
-----------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
31.00
38%
12
- C1 -
3NYO
2
GRK6_HUMAN
A:
[4-518]
--
E
L
E
N
I
V
A
N
T
V
L
L
K
A
R
E
G
G
G
G
N
--
R
K
G
K
S
K
---
K
W
--
R
----
Q
M
L
Q
F
P
H
I
S
Q
C
E
E
L
R
L
S
L
E
R
D
Y
H
S
L
C
E
----
R
Q
P
I
G
R
L
L
F
R
E
F
C
A
T
R
-
P
E
L
S
R
C
----
V
A
----
F
L
D
G
V
A
E
Y
E
V
T
P
D
D
K
R
K
A
C
-
G
R
Q
L
T
Q
N
F
L
S
H
T
G
-
P
D
L
I
P
E
V
P
R
Q
L
V
T
N
C
T
Q
R
L
E
Q
G
P
C
K
D
-
L
F
Q
E
L
T
R
L
T
H
E
Y
L
S
V
A
P
F
A
D
Y
L
D
S
I
Y
F
N
R
F
L
Q
W
K
W
L
E
R
Q
-
P
V
T
K
N
T
F
R
Q
Y
R
V
L
G
K
G
G
F
G
E
V
C
A
C
Q
V
---
R
---
A
---
T
G
K
M
Y
A
C
K
K
L
E
K
K
R
I
-
K
K
R
K
G
-
E
A
M
A
L
N
-
E
K
Q
I
L
E
K
V
N
S
R
---
F
V
V
S
L
A
Y
A
Y
E
T
K
D
A
L
C
L
V
L
T
L
M
N
G
G
D
L
K
F
H
I
Y
H
M
----
G
Q
A
G
-------
F
P
E
A
R
A
V
F
Y
A
A
E
I
C
C
G
L
E
D
L
H
R
-
E
R
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
D
H
G
H
I
R
I
S
D
L
G
L
---
A
V
H
V
--
P
---
E
--
G
-
Q
-
T
I
K
-
G
R
V
--
G
T
V
G
Y
M
A
P
E
-
V
V
-
K
N
E
R
Y
T
F
S
P
D
W
W
A
L
G
C
L
L
Y
E
M
I
A
G
Q
S
P
F
Q
---
K
K
-
I
--
K
-
R
E
E
V
E
R
L
V
K
E
V
P
E
E
Y
S
E
R
F
S
P
Q
A
R
S
L
C
S
Q
L
L
C
K
D
P
A
E
R
L
G
C
R
-
G
-
G
S
A
R
E
V
K
E
H
P
L
F
K
K
L
N
F
K
R
L
G
A
G
M
L
E
P
P
F
K
P
D
P
Q
A
I
Y
C
K
D
V
L
D
I
E
Q
F
S
--
T
V
-
K
G
V
E
L
---------
E
P
T
--------
D
Q
D
F
Y
Q
K
F
A
-
T
G
S
V
P
I
P
W
Q
N
E
M
V
E
T
-
E
-
C
F
Q
E
L
N
V
F
G
L
D
G
S
V
P
P
D
L
D
W
K
G
Q
P
P
A
P
P
K
K
G
L
L
Q
R
L
F
S
-----------------------------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
30.87
38%
10
- C1 -
3NYO
2
GRK6_HUMAN
B:
[4-518]
--
E
L
E
N
I
V
A
N
T
V
L
L
K
A
R
E
G
G
G
G
N
--
R
K
G
K
S
K
---
K
W--
R
----
Q
M
L
Q
F
P
H
I
S
Q
C
E
E
L
R
L
S
L
E
R
D
Y
H
S
L
C
E
----
R
Q
P
I
G
R
L
L
F
R
E
F
C
A
T
R
-
P
E
L
S
R
C
----
V
A
----
F
L
D
G
V
A
E
Y
E
V
T
P
D
D
K
R
K
A
C
-
G
R
Q
L
T
Q
N
F
L
S
H
T
G
-
P
D
L
I
P
E
V
P
R
Q
L
V
T
N
C
T
Q
R
L
E
Q
G
P
C
K
D
-
L
F
Q
E
L
T
R
L
T
H
E
Y
L
S
V
A
P
F
A
D
Y
L
D
S
I
Y
F
N
R
F
L
Q
W
K
W
L
E
R
Q
-
P
V
T
K
N
T
F
R
Q
Y
R
V
L
G
K
G
G
F
G
E
V
C
A
C
Q
V
---
R
---
A
---
T
G
K
M
Y
A
C
K
K
L
E
K
K
R
I
-
K
K
R
K
G
-
E
A
M
A
L
N
-
E
K
Q
I
L
E
K
V
N
S
R
---
F
V
V
S
L
A
Y
A
Y
E
T
K
D
A
L
C
L
V
L
T
L
M
N
G
G
D
L
K
FHI
Y
H
M
----
G
Q
A
G
-------
F
P
E
A
R
A
V
F
Y
A
A
E
I
C
C
G
L
E
D
L
H
R
-
E
R
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
D
H
G
H
I
R
I
S
D
L
G
L
---
A
V
H
V
--
P
---
E
--
G
-
Q
-
T
I
K
-
G
R
V
--
G
T
V
G
Y
M
A
P
E
-
V
V
-
K
N
E
R
Y
T
F
S
P
D
W
W
A
L
G
C
L
L
Y
E
M
I
A
G
Q
S
P
F
Q
---
K
K
-
I
--
K
-
R
E
E
V
E
R
L
V
K
E
V
P
E
E
Y
S
E
R
F
S
P
Q
A
R
S
L
C
S
Q
L
L
C
K
D
P
A
E
R
L
G
C
R
-
G
-
G
S
A
R
E
V
K
E
H
P
L
F
K
K
L
N
F
K
R
L
G
A
G
M
L
E
P
P
F
K
P
D
P
Q
A
I
Y
C
K
D
V
L
D
I
E
Q
F
S
--
T
V
-
K
G
V
E
L
---------
E
P
T
--------
D
Q
D
F
Y
Q
K
F
A
-
T
G
S
V
P
I
P
W
Q
N
E
M
V
E
T
-
E
-
C
F
Q
E
L
N
V
F
G
L
D
G
S
V
P
P
D
L
D
W
K
G
Q
P
P
A
P
P
K
K
G
L
L
Q
R
L
F
S
-----------------------------------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
30.61
38%
14
- C1 -
3NYN
2
GRK6_HUMAN
B:
[4-518]
--
E
L
E
N
I
V
A
N
T
V
L
L
K
A
R
E
G
G
G
G
N
--
R
K
G
K
S
K
---
K
W--
R
----
Q
M
L
Q
F
P
H
I
S
Q
C
E
E
L
R
L
S
L
E
R
D
Y
H
S
L
C
E
----
R
Q
P
I
G
R
L
L
F
R
E
F
C
A
T
R
-
P
E
L
S
R
C
----
V
A
----
F
L
D
G
V
A
E
Y
E
V
T
P
D
D
K
R
K
A
C
-
G
R
Q
L
T
Q
N
F
L
S
H
T
G
-
P
D
L
I
P
E
V
P
R
Q
L
V
T
N
C
T
Q
R
L
E
Q
G
P
C
K
D
-
L
F
Q
E
L
T
R
L
T
H
E
Y
L
S
V
A
P
F
A
D
Y
L
D
S
I
Y
F
N
R
F
L
Q
W
K
W
L
E
R
Q
-
P
V
T
K
N
T
F
R
Q
Y
R
V
L
G
K
G
G
F
G
E
V
C
A
C
Q
V
---
R
---
A
---
T
G
K
M
Y
A
C
K
K
L
E
K
K
R
I
-
K
K
R
K
G
-
E
A
M
A
L
N
-
E
K
Q
I
L
E
K
V
N
S
R
---
F
V
V
S
L
A
Y
A
Y
E
T
K
D
A
L
C
L
V
L
T
L
M
N
G
G
D
L
K
FHI
Y
H
M
----
G
Q
A
G
-------
F
P
E
A
R
A
V
F
Y
A
A
E
I
C
C
G
L
E
D
L
H
R
-
E
R
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
D
H
G
H
I
R
I
S
D
L
G
L
---
A
V
H
V
--
P
---
E
--
G
-
Q
-
T
I
K
-
G
R
V
--
G
T
V
G
Y
M
A
P
E
-
V
V
-
K
N
E
R
Y
T
F
S
P
D
W
W
A
L
G
C
L
L
Y
E
M
I
A
G
Q
S
P
F
Q
---
K
K
-
I
--
K
-
R
E
E
V
E
R
L
V
K
E
V
P
E
E
Y
S
E
R
F
S
P
Q
A
R
S
L
C
S
Q
L
L
C
K
D
P
A
E
R
L
G
C
R
-
G
-
G
S
A
R
E
V
K
E
H
P
L
F
K
K
L
N
F
K
R
L
G
A
G
M
L
E
P
P
F
K
P
D
P
Q
A
I
Y
C
K
D
V
L
D
I
E
Q
F
S
--
T
V
-
K
G
V
E
L
---------
E
P
T
--------
D
Q
D
F
Y
Q
K
F
A
-
T
G
S
V
P
I
P
W
Q
N
E
M
V
E
T
-
E
-
C
F
Q
E
L
N
V
F
G
L
D
G
S
V
P
P
D
L
D
W
K
G
Q
P
P
A
P
P
K
K
G
L
L
Q
R
L
F
S
-----------------------------------------------------------------------------------------------------------------------------
77
PsiBlast_CBE
12.27
33%
14
- C1 -
2UZV
1
KAPCA_BOVIN
A:
[2-322]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
E
F
L
A
K
A
K
E
D
F
L
K
K
W
E
N
P
A
Q
N
T
-
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
---
M
---
E
---
T
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
K
Q
I
-
E
H
-
T
L
N
-
E
K
R
I
L
Q
A
V
---
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
---
S
H
L
----
R
R
I
G
----
R
--
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
---
A
K
R
---
V
---
K
--
G
-
R
-
T
-
W
-
T
L
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
--
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
-
Q
--
I
-
Y
-
E
---
K
I
V
S
G
K
V
R
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
L
-
K
-
D
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
--
D
Y
E
E
E
E
I
-
R
V
S
I
N
---------
E
K
C
--------
G
K
E
F
S
E
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------