@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : BMP2K_HUMAN: (2015-10-04 )
MKKFSRMPKSEGGSGGGAAGGGAGGAGAGAGCGSGGSSVGVRVFAVGRHQVTLEESLAEGGFSTVFLVRTHGGIRCALKRMYVNNMPDLNVCKREITIMKELSGHKNIVGYLDCAVNSISDNVWEVLILMEYCRAGQVVNQMNKKLQTGFTEPEVLQIFCDTCEAVARLHQCKTPIIHRDLKVENILLNDGGNYVLCDFGSATNKFLNPQKDGVNVVEEEIKKYTTLSYRAPEMINLYGGKPITTKADIWALGCLLYKLCFFTLPFGESQVAICDGNFTIPDNSRYSRNIHCLIRFMLEPDPEHRPDIFQVSYFAFKFAKKDCPVSNINNSSIPSALPEPMTASEAAARKSQIKARITDTIGPTETSIAPRQRPKANSATTATPSVLTIQSSATPVKVLAPGEFGNHRPKGALRPGNGPEILLGQGPPQQPPQQHRVLQQLQQGDWRLQQLHLQHRHPHQQQQQQQQQQQQQQQQQQQQQQQQQQQHHHHHHHHLLQDAYMQQYQHATQQQQMLQQQFLMHSVYQPQPSASQYPTMMPQYQQAFFQQQMLAQHQPSQQQASPEYLTSPQEFSPALVSYTSSLPAQVGTIMDSSYSANRSVADKEAIANFTNQKNISNPPDMSGWNPFGEDNFSKLTEEELLDREFDLLRSNRLEERASSDKNVDSLSAPHNHPPEDPFGSVPFISHSGSPEKKAEHSSINQENGTANPIKNGKTSPASKDQRTGKKTSVQGQVQKGNDESESDFESDPPSPKSSEEEEQDDEEVLQGEQGDFNDDDTEPENLGHRPLLMDSEDEEEEEKHSSDSDYEQAKAKYSDMSSVYRDRSGSGPTQDLNTILLTSAQLSSDVAVETPKQEFDVFGAVPFFAVRAQQPQQEKNEKNLPQHRFPAAGLEQEEFDVFTKAPFSKKVNVQECHAVGPEAHTIPGYPKSVDVFGSTPFQPFLTSTSKSESNEDLFGLVPFDEITGSQQQKVKQRSLQKLSSRQRRTKQDMSKSNGKRHHGTPTSTKKTLKPTYRTPERARRHKKVGRRDSQSSNEFLTISDSKENISVALTDGKDRGNVLQPEESLLDPFGAKPFHSPDLSWHPPHQGLSDIRADHNTVLPGRPRQNSLHGSFHSADVLKMDDFGAVPFTELVVQSITPHQSQQSQPVELDPFGAAPFPSKQ
Atome Classification :
(16 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120........130.......140..--.....150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260...---....270--......-.280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770.......780.......790.......800.......810.......820.......830.......840.......850.......860.......870.......880.......890.......900.......910.......920.......930.......940.......950.......960.......970.......980.......990.......1000......1010......1020......1030......1040......1050......1060......1070......1080......1090......1100......1110......1120......1130......1140......1150......1160
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MK
K
F
SRMPKSEGGSGGGAAGGGAGGAGAGAGCGSGGS
S
V
G
V
R
V
F
A
VG
R
H
Q
V
T
L
E
E
S
L
AEGG
F
S
T
V
F
L
V
RTHG
G
I
R
C
A
L
K
R
M
Y
VNNMP
D
L
N
V
C
K
R
E
I
T
I
M
K
E
LSGHK
N
I
V
G
Y
L
D
C
A
V
N
SI
S
D
-
N
V
W
E
V
L
I
L
M
E
Y
C
R
A
G
Q
V
V
N
Q
M
N
K
--
K
L
QTGFT
E
P
E
V
L
Q
I
F
C
D
T
C
E
A
V
A
R
L
H
QCKTP
I
I
HRD
L
K
V
E
N
I
L
LNDGG
N
Y
V
L
CDFGS
A
T
N
KFLNPQKD
G
V
N
V
V
E
E
E
I
K
K
YTTLSYRAP
E
M
I
NLYGGKPITT
K
A
D
I
W
A
L
G
C
L
L
Y
K
L
C
F
F
TLP---FGE
S
Q
V
A
--
I
CDG
N
F
-TIPDNSRYS
R
N
I
H
C
L
I
R
F
MLEPDPEHRP
D
I
F
Q
V
S
Y
F
A
F
K
F
AKKDCPVSNINNSSIPSALPEPM
T
A
S
E
A
A
A
R
K
S
Q
I
K
A
R
I
TDTIGPTETSIAPRQRPKANSATTAT
P
S
V
L
T
IQSSA
T
P
V
K
V
LAPGEFGNHRPKGALRPGNGP
E
I
L
LGQGPPQQP
P
Q
Q
H
R
V
L
Q
Q
L
Q
QGD
W
R
L
Q
Q
L
H
L
Q
HRHP
H
Q
Q
Q
Q
Q
Q
Q
Q
Q
Q
Q
Q
Q
Q
Q
Q
Q
Q
Q
Q
Q
Q
Q
Q
Q
Q
Q
H
H
H
H
H
H
H
H
L
L
Q
D
A
Y
M
Q
Q
Y
Q
H
A
T
Q
Q
Q
Q
M
L
Q
Q
Q
F
L
M
H
S
VYQPQPSASQYPTM
M
P
Q
Y
Q
Q
A
F
F
Q
Q
Q
M
L
A
QHQPSQQQASPEYLT
S
P
Q
EF
S
P
A
L
V
S
Y
T
SSLP
A
Q
V
G
T
I
MDSSYSANRSVA
D
K
E
A
I
A
N
FTNQKNISNPPDMSGWNPFGE
D
N
F
S
K
L
T
E
E
E
L
L
D
R
E
F
D
L
L
R
S
N
R
L
E
E
R
ASSDKNVDSLSAPHNHPPEDPFGSVPFISHSGSPEKKAEHSSINQENGTANPIKNGKTSPASKDQRTGKKTSV
Q
G
Q
V
QKGNDESESDFESDPPSPKSSEEEEQ
D
D
E
E
V
LQGEQGDFNDDDTEPENLGHRPLLMDSED
E
E
E
E
EKHSSDS
D
Y
E
Q
A
K
A
K
Y
S
D
M
S
S
V
Y
RDRSGSGPTQDL
N
T
I
L
L
TSAQLSSDVAVET
P
K
Q
E
F
D
VFGAV
P
F
F
A
VRAQQPQQEKNEKNLPQHRFPAAGL
E
Q
E
E
F
D
V
FTKAPFSKKV
N
V
Q
E
C
HAVGPEAHTIPGYPK
S
V
DVFGSTPF
Q
P
FLTSTSKSESNE
D
L
F
GLV
P
F
D
E
IT
G
S
Q
Q
Q
K
V
K
Q
R
S
L
Q
K
L
S
S
R
Q
R
R
T
K
Q
D
M
S
KSNGKRHHGTPTSTKKTLKPTYR
T
P
E
R
A
R
R
H
K
K
VGRRDSQSSN
E
F
L
T
ISDSKE
N
I
S
V
A
L
TDGKDRGNVLQ
P
E
E
S
LLDPFGAKPFHSPDLSWHPPHQ
G
L
S
D
I
RADHNTVLPGRPRQNSLHGSFHSA
D
V
L
K
MDDFGAV
P
F
T
E
L
V
V
Q
SITPHQSQQSQPVELDPFGAAPFPSKQ
2
PsiBlast_PDB
98.04
99%
-128
- C1 -
4W9W
7
BMP2K_HUMAN
A:
[1-306]
--------------------------------------
V
G
V
R
V
F
A
V
G
R
H
Q
V
T
L
E
E
S
L
A
E
G
G
F
S
T
V
F
L
V
R
T
H
G
G
I
R
C
A
L
K
R
M
Y
V
N
N
M
P
D
L
N
V
C
K
R
E
I
T
I
M
K
E
L
S
G
H
K
N
I
V
G
Y
L
D
C
A
V
N
S
I
S
D
-
N
V
W
E
V
L
I
L
M
E
Y
C
R
A
G
Q
V
V
N
Q
M
N
K
--
K
L
Q
T
G
F
T
E
P
E
V
L
Q
I
F
C
D
T
C
E
A
V
A
R
L
H
Q
C
K
T
P
I
I
H
R
D
L
K
V
E
N
I
L
L
N
D
G
G
N
Y
V
L
C
D
F
G
S
A
T
N
K
F
L
N
P
Q
K
D
G
V
N
V
V
E
E
E
I
K
K
Y
T
T
L
S
Y
R
A
P
E
M
I
N
L
Y
G
G
K
P
I
T
T
K
A
D
I
W
A
L
G
C
L
L
Y
K
L
C
F
F
T
L
P
---
F
G
E
S
Q
V
A
--
I
C
D
G
N
F
-
T
I
P
D
N
S
R
Y
S
R
N
I
H
C
L
I
R
F
M
L
E
P
D
P
E
H
R
P
D
I
F
Q
V
S
Y
F
A
F
K
F
A
A
A
D
C
P
V
S
N
I
N
N
S
S
I
P
S
A
L
P
E
P
M
T
A
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
96.81
99%
-129
- C1 -
4W9X
3
BMP2K_HUMAN
A:
[4-307]
--------------------------------------
V
G
V
R
V
F
A
V
G
R
H
Q
V
T
L
E
E
S
L
A
E
G
G
F
S
T
V
F
L
V
R
T
H
G
G
I
R
C
A
L
K
R
M
Y
V
N
N
M
P
D
L
N
V
C
K
R
E
I
T
I
M
K
E
L
S
G
H
K
N
I
V
G
Y
L
D
C
A
V
N
S
I
S
----
W
E
V
L
I
L
M
E
Y
C
R
A
G
Q
V
V
N
Q
M
N
K
--
K
-
Q
T
G
F
T
E
P
E
V
L
Q
I
F
C
D
T
C
E
A
V
A
R
L
H
Q
C
K
T
P
I
I
H
R
D
L
K
V
E
N
I
L
L
N
D
G
G
N
Y
V
L
C
D
F
G
S
A
T
N
K
F
L
N
P
Q
K
D
G
V
N
V
V
E
E
E
I
K
K
Y
T
T
L
S
Y
R
A
P
E
M
I
N
L
Y
G
G
K
P
I
T
T
K
A
D
I
W
A
L
G
C
L
L
Y
K
L
C
F
F
T
L
P
---
F
G
E
S
Q
V
A
--
I
C
D
G
N
F
-
T
I
P
D
N
S
R
Y
S
R
N
I
H
C
L
I
R
F
M
L
E
P
D
P
E
H
R
P
D
I
F
Q
V
S
Y
F
A
F
K
F
A
A
A
D
C
P
V
S
N
I
N
N
S
S
I
P
S
A
L
P
E
P
M
T
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
88.03
76%
-120
- C1 -
4WSQ
2
AAK1_HUMAN
A:
[1-317]
--------------------------------
G
L
G
S
G
Y
I
G
-
R
V
F
G
I
G
R
Q
Q
V
T
V
D
E
V
L
A
E
G
G
F
A
I
V
F
L
V
R
T
S
N
G
M
K
C
A
L
K
R
M
F
V
N
N
E
H
D
L
Q
V
C
K
R
E
I
Q
I
M
R
D
L
S
G
H
K
N
I
V
G
Y
I
D
S
S
I
N
N
V
S
S
G
D
V
W
E
V
L
I
L
M
D
F
C
R
G
G
Q
V
V
N
L
M
N
Q
--
R
L
Q
T
G
F
T
E
N
E
V
L
Q
I
F
C
D
T
C
E
A
V
A
R
L
H
Q
C
K
T
P
I
I
H
R
D
L
K
V
E
N
I
L
L
H
D
R
G
H
Y
V
L
C
D
F
G
S
A
T
N
K
F
Q
N
P
Q
T
E
G
V
N
A
V
E
D
E
I
K
K
Y
T
T
L
S
Y
R
A
P
E
M
V
N
L
Y
S
G
K
I
I
T
T
K
A
D
I
W
A
L
G
C
L
L
Y
K
L
C
Y
F
T
L
P
---
F
G
E
S
Q
V
A
--
I
C
D
G
N
F
-
T
I
P
D
N
S
R
Y
S
Q
D
M
H
C
L
I
R
Y
M
L
E
P
D
P
D
K
R
P
D
I
Y
Q
V
S
Y
F
S
F
K
L
L
K
K
E
C
P
I
P
N
V
Q
N
S
P
I
P
A
K
L
P
E
P
V
K
A
S
E
A
A
A
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
86.29
76%
-121
- C1 -
4WSQ
1
AAK1_HUMAN
B:
[5-314]
------------------------------------
G
Y
I
G
-
R
V
F
G
I
G
R
Q
Q
V
T
V
D
E
V
L
A
E
G
G
F
A
I
V
F
L
V
R
T
S
N
G
M
K
C
A
L
K
R
M
F
V
N
N
E
H
D
L
Q
V
C
K
R
E
I
Q
I
M
R
D
L
S
G
H
K
N
I
V
G
Y
I
D
S
S
I
N
N
V
S
S
G
D
V
W
E
V
L
I
L
M
D
F
C
R
G
G
Q
V
V
N
L
M
N
Q
--
R
L
Q
T
G
F
T
E
N
E
V
L
Q
I
F
C
D
T
C
E
A
V
A
R
L
H
Q
C
K
T
P
I
I
H
R
D
L
K
V
E
N
I
L
L
H
D
R
G
H
Y
V
L
C
D
F
G
S
A
T
N
K
F
Q
N
P
Q
T
E
G
V
N
A
V
E
D
E
I
K
K
Y
T
T
L
S
Y
R
A
P
E
M
V
N
L
Y
S
G
K
I
I
T
T
K
A
D
I
W
A
L
G
C
L
L
Y
K
L
C
Y
F
T
L
P
---
F
G
E
S
Q
V
A
--
I
C
D
G
N
F
-
T
I
P
D
N
S
R
Y
S
Q
D
M
H
C
L
I
R
Y
M
L
E
P
D
P
D
K
R
P
D
I
Y
Q
V
S
Y
F
S
F
K
L
L
K
K
E
C
P
I
P
N
V
Q
N
S
P
I
P
A
K
L
P
E
P
V
K
A
S
E
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
56.31
31%
-121
- C1 -
2JAV
1
NEK2_HUMAN
A:
[55-265]
----------------------------------------------------------------------------------------------
E
V
N
L
L
R
E
L
K
-
H
P
N
I
V
R
Y
Y
D
R
I
I
D
-----
T
L
Y
---
I
V
M
E
Y
C
E
G
G
D
L
A
S
V
I
T
K
G
T
K
E
R
Q
Y
L
D
E
E
F
V
L
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
R
R
S
D
------
L
K
P
A
N
V
F
L
D
G
K
Q
N
V
K
L
G
D
F
G
L
A
--
R
I
L
-----------------
G
T
P
Y
Y
M
S
P
E
Q
M
N
R
M
S
---
Y
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
L
M
P
P
FTA
F
S
Q
K
E
L
A
G
K
I
R
E
G
K
F
R
R
I
P
--
Y
R
Y
S
D
E
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
R
P
S
V
E
E
I
L
E
N
P
L
I
L
E
H
H
H
H
H
H
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28
PsiBlast_CBE
54.99
31%
-125
- C1 -
2XKE
1
NEK2_HUMAN
A:
[55-265]
----------------------------------------------------------------------------------------------
E
V
N
L
L
R
E
L
K
-
H
P
N
I
V
R
Y
Y
D
R
I
I
D
R
T
N
T
-
T
L
Y
---
I
V
M
E
Y
C
E
G
G
D
L
A
S
V
I
T
K
G
T
K
E
R
Q
Y
L
D
E
E
F
V
L
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
R
R
S
D
------
L
K
P
A
N
V
F
L
D
G
K
Q
N
V
K
L
G
D
F
--------------------------
T
P
Y
Y
M
S
P
E
Q
M
N
-------
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
L
M
P
P
FTA
F
S
Q
K
E
L
A
G
K
I
R
E
G
K
F
R
R
I
P
--
Y
R
Y
S
D
E
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
R
P
S
V
E
E
I
L
E
N
P
L
I
L
E
H
H
H
H
H
H
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
PsiBlast_CBE
50.63
31%
-112
- C1 -
2XNP
5
NEK2_HUMAN
A:
[55-265]
----------------------------------------------------------------------------------------------
E
V
N
L
L
R
E
L
K
-
H
P
N
I
V
R
Y
Y
D
R
I
I
D
R
T
N
T
-
T
L
Y
---
I
V
M
E
Y
C
E
G
G
D
L
A
S
V
I
T
K
G
T
K
E
R
Q
Y
L
D
E
E
F
V
L
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
R
R
S
----
H
R
D
L
K
P
A
N
V
F
L
D
G
K
Q
N
V
K
L
G
D
F
G
L
---------------
F
------
V
G
T
P
Y
Y
M
S
P
E
Q
M
N
R
------
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
L
M
P
P
FTA
F
S
Q
K
E
L
A
G
K
I
R
E
G
K
F
R
R
I
P
--
Y
R
Y
S
D
E
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
R
P
S
V
E
E
I
L
E
N
P
L
I
L
E
H
H
H
H
H
H
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
50.61
31%
-118
- C1 -
2W5A
5
NEK2_HUMAN
A:
[55-265]
----------------------------------------------------------------------------------------------
E
V
N
L
L
R
E
L
K
-
H
P
N
I
V
R
Y
Y
D
R
I
I
D
R
T
N
T
-
T
L
Y
---
I
V
M
E
Y
C
E
G
G
D
L
A
S
V
I
T
K
G
T
K
E
R
Q
Y
L
D
E
E
F
V
L
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
R
R
S
---
L
H
R
D
L
K
P
A
N
V
F
L
D
G
K
Q
N
V
K
L
G
D
F
G
L
A
--
R
I
L
---
T
S
F
A
K
T
F
------
V
G
T
P
Y
Y
M
S
P
E
Q
M
N
R
M
----
Y
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
L
M
P
P
FTA
F
S
Q
K
E
L
A
G
K
I
R
E
G
K
F
R
R
I
P
--
Y
R
Y
S
D
E
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
R
P
S
V
E
E
I
L
E
N
P
L
I
L
E
H
H
H
H
H
H
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
50.50
31%
-117
- C1 -
2XK8
1
NEK2_HUMAN
A:
[55-265]
----------------------------------------------------------------------------------------------
E
V
N
L
L
R
E
L
K
-
H
P
N
I
V
R
Y
Y
D
R
I
I
D
R
T
N
T
-
T
L
Y
---
I
V
M
E
Y
C
E
G
G
D
L
A
S
V
I
T
K
G
T
K
E
R
Q
Y
L
D
E
E
F
V
L
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
R
R
S
-----
R
D
L
K
P
A
N
V
F
L
D
G
K
Q
N
V
K
L
G
D
F
-----------------
F
------
V
G
T
P
Y
Y
M
S
P
E
Q
M
N
-------
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
L
M
P
P
FTA
F
S
Q
K
E
L
A
G
K
I
R
E
G
K
F
R
R
I
P
--
Y
R
Y
S
D
E
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
R
P
S
V
E
E
I
L
E
N
P
L
I
L
E
H
H
H
H
H
H
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
PsiBlast_CBE
50.35
31%
-115
- C1 -
2XNN
5
NEK2_HUMAN
A:
[55-265]
----------------------------------------------------------------------------------------------
E
V
N
L
L
R
E
L
K
-
H
P
N
I
V
R
Y
Y
D
R
I
I
D
R
T
N
T
-
T
L
Y
---
I
V
M
E
Y
C
E
G
G
D
L
A
S
V
I
T
K
G
T
K
E
R
Q
Y
L
D
E
E
F
V
L
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
R
R
S
-----
R
D
L
K
P
A
N
V
F
L
D
G
K
Q
N
V
K
L
G
D
F
G
----------------
F
------
V
G
T
P
Y
Y
M
S
P
E
Q
M
N
R
-----
Y
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
L
M
P
P
FTA
F
S
Q
K
E
L
A
G
K
I
R
E
G
K
F
R
R
I
P
--
Y
R
Y
S
D
E
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
R
P
S
V
E
E
I
L
E
N
P
L
I
L
E
H
H
H
H
H
H
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
50.32
31%
-113
- C1 -
2XK4
1
NEK2_HUMAN
A:
[55-265]
----------------------------------------------------------------------------------------------
E
V
N
L
L
R
E
L
K
-
H
P
N
I
V
R
Y
Y
D
R
I
I
D
R
T
N
T
-
T
L
Y
---
I
V
M
E
Y
C
E
G
G
D
L
A
S
V
I
T
K
G
T
K
E
R
Q
Y
L
D
E
E
F
V
L
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
R
R
S
-----
R
D
L
K
P
A
N
V
F
L
D
G
K
Q
N
V
K
L
G
D
F
G
L
---------------
F
------
V
G
T
P
Y
Y
M
S
P
E
Q
M
N
R
M
-----
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
L
M
P
P
FTA
F
S
Q
K
E
L
A
G
K
I
R
E
G
K
F
R
R
I
P
--
Y
R
Y
S
D
E
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
R
P
S
V
E
E
I
L
E
N
P
L
I
L
E
H
H
H
H
H
H
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
PsiBlast_CBE
50.03
31%
-116
- C1 -
2XNO
12
NEK2_HUMAN
A:
[55-265]
----------------------------------------------------------------------------------------------
E
V
N
L
L
R
E
L
K
-
H
P
N
I
V
R
Y
Y
D
R
I
I
D
R
T
N
T
-
T
L
Y
---
I
V
M
E
Y
C
E
G
G
D
L
A
S
V
I
T
K
G
T
K
E
R
Q
Y
L
D
E
E
F
V
L
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
R
R
S
-----
R
D
L
K
P
A
N
V
F
L
D
G
K
Q
N
V
K
L
G
D
F
-----------------
F
------
V
G
T
P
Y
Y
M
S
P
E
Q
M
N
R
------
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
L
M
P
P
FTA
F
S
Q
K
E
L
A
G
K
I
R
E
G
K
F
R
R
I
P
--
Y
R
Y
S
D
E
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
R
P
S
V
E
E
I
L
E
N
P
L
I
L
E
H
H
H
H
H
H
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
48.80
31%
-116
- C1 -
2XK6
1
NEK2_HUMAN
A:
[55-265]
----------------------------------------------------------------------------------------------
E
V
N
L
L
R
E
L
K
-
H
P
N
I
V
R
Y
Y
D
R
I
I
D
R
T
N
T
-
T
L
Y
---
I
V
M
E
Y
C
E
G
G
D
L
A
S
V
I
T
K
G
T
K
E
R
Q
Y
L
D
E
E
F
V
L
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
R
R
S
-----
R
D
L
K
P
A
N
V
F
L
D
G
K
Q
N
V
K
L
G
D
-------------------------
V
G
T
P
Y
Y
M
S
P
E
Q
M
N
R
------
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
L
M
P
P
FTA
F
S
Q
K
E
L
A
G
K
I
R
E
G
K
F
R
R
I
P
--
Y
R
Y
S
D
E
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
R
P
S
V
E
E
I
L
E
N
P
L
I
L
E
H
H
H
H
H
H
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
PsiBlast_CBE
48.74
31%
-111
- C1 -
2XNM
10
NEK2_HUMAN
A:
[55-265]
----------------------------------------------------------------------------------------------
E
V
N
L
L
R
E
L
K
-
H
P
N
I
V
R
Y
Y
D
R
I
I
D
R
T
N
T
-
T
L
Y
---
I
V
M
E
Y
C
E
G
G
D
L
A
S
V
I
T
K
G
T
K
E
R
Q
Y
L
D
E
E
F
V
L
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
R
R
------
R
D
L
K
P
A
N
V
F
L
D
G
K
Q
N
V
K
L
G
D
F
G
L
A
--
R
I
L
---------
F
------
V
G
T
P
Y
Y
M
S
P
E
Q
M
N
R
-
S
---
Y
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
L
M
P
P
FTA
F
S
Q
K
E
L
A
G
K
I
R
E
G
K
F
R
R
I
P
--
Y
R
Y
S
D
E
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
R
P
S
V
E
E
I
L
E
N
P
L
I
L
E
H
H
H
H
H
H
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
46.63
31%
-111
- C1 -
2XK3
1
NEK2_HUMAN
A:
[55-265]
----------------------------------------------------------------------------------------------
E
V
N
L
L
R
E
L
K
-
H
P
N
I
V
R
Y
Y
D
R
I
I
D
R
T
N
T
-
T
L
Y
---
I
V
M
E
Y
C
E
G
G
D
L
A
S
V
I
T
K
G
T
K
E
R
Q
Y
L
D
E
E
F
V
L
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
R
R
S
-----
R
D
L
K
P
A
N
V
F
L
D
G
K
Q
N
V
K
L
G
D
F
G
-----------------------
V
G
T
P
Y
Y
M
S
P
E
Q
M
N
R
------
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
L
M
P
P
FTA
F
S
Q
K
E
L
A
G
K
I
R
E
G
K
F
R
R
I
P
--
Y
R
Y
S
D
E
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
R
P
S
V
E
E
I
L
E
N
P
L
I
L
E
H
H
H
H
H
H
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
46.34
31%
-111
- C1 -
2W5B
1
NEK2_HUMAN
A:
[55-265]
----------------------------------------------------------------------------------------------
E
V
N
L
L
R
E
L
K
-
H
P
N
I
V
R
Y
Y
D
R
I
I
D
R
T
N
T
-
T
L
Y
---
I
V
M
E
Y
C
E
G
G
D
L
A
S
V
I
T
K
G
T
K
E
R
Q
Y
L
D
E
E
F
V
L
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
R
R
S
---
L
H
R
D
L
K
P
A
N
V
F
L
D
G
K
Q
N
V
K
L
G
D
F
G
L
A
--
R
I
L
N
H
D
T
S
F
A
K
A
F
------
V
G
T
P
Y
Y
M
S
P
E
Q
M
N
R
M
S
---
Y
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
L
M
P
P
FTA
F
S
Q
K
E
L
A
G
K
I
R
E
G
K
F
R
R
I
P
--
Y
R
Y
S
D
E
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
R
P
S
V
E
E
I
L
E
N
P
L
I
L
E
H
H
H
H
H
H
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------