@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : BMR1A_HUMAN: (2015-10-04 )
MPQLYIYIRLLGAYLFIISRVQGQNLDSMLHGTGMKSDSDQKKSENGVTLAPEDTLPFLKCYCSGHCPDDAINNTCITNGHCFAIIEEDDQGETTLASGCMKYEGSDFQCKDSPKAQLRRTIECCRTNLCNQYLQPTLPPVVIGPFFDGSIRWLVLLISMAVCIIAMIIFSSCFCYKHYCKSISSRRRYNRDLEQDEAFIPVGESLKDLIDQSQSSGSGSGLPLLVQRTIAKQIQMVRQVGKGRYGEVWMGKWRGEKVAVKVFFTTEEASWFRETEIYQTVLMRHENILGFIAADIKGTGSWTQLYLITDYHENGSLYDFLKCATLDTRALLKLAYSAACGLCHLHTEIYGTQGKPAIAHRDLKSKNILIKKNGSCCIADLGLAVKFNSDTNEVDVPLNTRVGTKRYMAPEVLDESLNKNHFQPYIMADIYSFGLIIWEMARRCITGGIVEEYQLPYYNMVPSDPSYEDMREVVCVKRLRPIVSNRWNSDECLRAVLKLMSECWAHNPASRLTALRIKKTLAKMVESQDVKI
Atome Classification :
(77 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200...-....210.......220.......230.......240.......250.......260....----...270.......280.......290.......300.......310.......320.--.--.....330.......340.......---350..--.....360.......370.......380..-.....390.......400.......410..-.....420.--..-....430.......440...-..-..450.......460.......470......--.480...-....490.......500.......510.......520.......530
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
P
Q
L
Y
I
Y
I
R
L
L
G
A
Y
L
F
I
I
S
RVQGQ
N
L
D
S
M
L
HGTGMKSDSDQKKSENG
V
T
LAPEDT
L
P
F
L
K
C
Y
CSGHCPDDAINNTCITNG
H
C
F
A
I
I
EEDDQGE
T
T
L
A
S
G
C
MKYEGSDFQCKDS
P
K
A
Q
L
R
R
T
I
E
C
C
R
T
N
L
C
N
Q
Y
LQPTLP
P
V
V
I
GPFFDG
S
I
R
W
L
V
L
L
I
S
M
A
V
C
I
I
A
M
I
I
F
S
S
C
F
C
Y
K
H
Y
C
K
S
I
S
S
R
R
RYNRDLEQDEAFIPV
G
E
S
-
L
K
D
L
I
D
QSQSSGSGSG
L
P
L
L
V
Q
R
T
I
A
K
Q
I
Q
M
V
R
Q
VGKGRYGE
V
W
M
GKWRG
E
K
V
A
V
K
V
F
F
TT----EEA
S
W
F
R
E
T
E
I
Y
Q
T
V
L
M
R
H
E
N
I
L
G
F
I
A
ADIKGTGS
W
T
Q
L
Y
L
I
T
D
YHENG
S
L
Y
D
F
L
K
C
--A--TL
D
T
R
A
L
L
K
L
A
Y
S
AACGL
C
H
L
H
T
E
I
---YGTQG--KP
A
I
AHRDLKSK
N
I
L
I
KKNG
S
C
C
I
ADL
G
L
A
-
V
K
FNSDTN
E
V
DVPLNTRVGTKRYM
A
P
E
V
L
D
-
E
S
LNKNHFQ--
P
Y
-
I
M
A
D
I
Y
S
F
G
L
I
I
W
E
M
A
R
R
C
I-TG-G
I
V
E
E
YQLPYYNMVPSDP
S
Y
E
D
M
R
E
V
V
C
V
K
R
--
L
R
P
I
V
SN-RW
N
S
D
E
C
L
R
A
V
L
K
L
M
S
E
C
WAH
N
P
A
S
R
L
T
A
L
R
I
K
K
T
L
A
K
M
V
E
SQDVKI
137
HHSearch
95.33
85%
-108
- C1 -
3MDY
1
BMR1B_HUMAN
A:
[9-337]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
-
L
R
D
L
I
E
Q
S
Q
S
S
G
S
G
S
G
L
P
L
L
V
Q
R
T
I
A
K
Q
I
Q
M
V
K
Q
I
G
K
G
R
Y
G
E
V
W
M
G
K
W
R
G
E
K
V
A
V
K
V
F
F
T
T
----
E
E
A
S
W
F
R
E
T
E
I
Y
Q
T
V
L
M
R
H
E
N
I
L
G
F
I
A
A
D
I
K
G
T
G
S
W
T
Q
L
Y
L
I
T
D
Y
H
E
N
G
S
L
Y
D
Y
L
K
S
--
T
--
T
L
D
A
K
S
M
L
K
L
A
Y
S
S
V
S
G
L
C
H
L
H
T
E
I
---
F
S
T
Q
G
--
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
T
C
C
I
A
D
L
G
L
A
-
V
K
F
I
---------
P
N
T
R
V
G
T
K
R
Y
M
P
P
E
V
L
D
-
E
S
L
N
R
N
H
F
Q
--
S
Y
-
I
M
A
D
M
Y
S
F
G
L
I
L
W
E
V
A
R
R
C
V
-
S
G
-
G
I
V
E
E
Y
Q
L
P
Y
H
D
L
V
P
S
D
P
S
Y
E
D
M
R
E
I
V
C
I
K
K
--
L
R
P
S
F
P
N
-
R
W
S
S
D
E
C
L
R
Q
M
G
K
L
M
T
E
C
W
A
H
N
P
A
S
R
L
T
A
L
R
V
K
K
T
L
A
K
M
S
E
S
Q
D
I
K
L
1
PsiBlast_PDB
95.33
85%
-108
- C1 -
3MDY
1
BMR1B_HUMAN
A:
[9-337]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
-
L
R
D
L
I
E
Q
S
Q
S
S
G
S
G
S
G
L
P
L
L
V
Q
R
T
I
A
K
Q
I
Q
M
V
K
Q
I
G
K
G
R
Y
G
E
V
W
M
G
K
W
R
G
E
K
V
A
V
K
V
F
F
T
T
----
E
E
A
S
W
F
R
E
T
E
I
Y
Q
T
V
L
M
R
H
E
N
I
L
G
F
I
A
A
D
I
K
G
T
G
S
W
T
Q
L
Y
L
I
T
D
Y
H
E
N
G
S
L
Y
D
Y
L
K
S
--
T
--
T
L
D
A
K
S
M
L
K
L
A
Y
S
S
V
S
G
L
C
H
L
H
T
E
I
---
F
S
T
Q
G
--
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
T
C
C
I
A
D
L
G
L
A
-
V
K
F
I
---------
P
N
T
R
V
G
T
K
R
Y
M
P
P
E
V
L
D
-
E
S
L
N
R
N
H
F
Q
--
S
Y
-
I
M
A
D
M
Y
S
F
G
L
I
L
W
E
V
A
R
R
C
V
-
S
G
-
G
I
V
E
E
Y
Q
L
P
Y
H
D
L
V
P
S
D
P
S
Y
E
D
M
R
E
I
V
C
I
K
K
--
L
R
P
S
F
P
N
-
R
W
S
S
D
E
C
L
R
Q
M
G
K
L
M
T
E
C
W
A
H
N
P
A
S
R
L
T
A
L
R
V
K
K
T
L
A
K
M
S
E
S
Q
D
I
K
L
21
PsiBlast_CBE
93.63
85%
-107
- C1 -
3MDY
1
BMR1B_HUMAN
C:
[9-335]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
-
L
R
D
L
I
E
Q
S
Q
S
S
G
S
G
S
G
L
P
L
L
V
Q
R
T
I
A
K
Q
I
Q
M
V
K
Q
I
G
K
G
R
Y
G
E
V
W
M
G
K
W
R
G
E
K
V
A
V
K
V
F
F
T
T
----
E
E
A
S
W
F
R
E
T
E
I
Y
Q
T
V
L
M
R
H
E
N
I
L
G
F
I
A
A
D
I
K
G
T
G
S
W
T
Q
L
Y
L
I
T
D
Y
H
E
N
G
S
L
Y
D
Y
L
K
S
--
T
--
T
L
D
A
K
S
M
L
K
L
A
Y
S
S
V
S
G
L
C
H
L
H
T
E
I
---
F
S
T
Q
G
--
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
T
C
C
I
A
D
L
G
L
A
-
V
K
F
I
-------
I
P
P
N
T
R
V
G
T
K
R
Y
M
P
P
E
V
L
D
-
E
S
L
N
R
N
H
F
Q
--
S
Y
-
I
M
A
D
M
Y
S
F
G
L
I
L
W
E
V
A
R
R
C
V
-
S
G
-
G
I
V
E
E
Y
Q
L
P
Y
H
D
L
V
P
S
D
P
S
Y
E
D
M
R
E
I
V
C
I
K
K
--
L
R
P
S
F
P
N
-
R
W
S
S
D
E
C
L
R
Q
M
G
K
L
M
T
E
C
W
A
H
N
P
A
S
R
L
T
A
L
R
V
K
K
T
L
A
K
M
S
E
S
Q
D
I
--
9
PsiBlast_PDB
87.65
64%
-111
- C1 -
2WOU
2
TGFR1_HUMAN
A:
[3-299]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
I
A
R
T
I
V
L
Q
E
S
I
G
K
G
R
F
G
E
V
W
R
G
K
W
R
G
E
E
V
A
V
K
I
F
S
S
R
----
E
E
R
S
W
F
R
E
A
E
I
Y
Q
T
V
M
L
R
H
E
N
I
L
G
F
I
A
A
D
N
K
D
N
G
T
W
T
Q
L
W
L
V
S
D
Y
H
E
H
G
S
L
F
D
Y
L
N
R
--
Y
--
T
V
T
V
E
G
M
I
K
L
A
L
S
T
A
S
G
L
A
H
L
H
M
E
I
---
V
G
T
Q
G
--
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
T
C
C
I
A
D
L
G
L
A
-
V
R
H
D
S
A
T
D
T
I
D
I
A
P
N
H
R
V
G
T
K
R
Y
M
A
P
E
V
L
D
-
D
S
I
N
M
K
H
F
E
--
S
F
-
K
R
A
D
I
Y
A
M
G
L
V
F
W
E
I
A
R
R
C
S
-
I
G
-
G
I
H
E
D
Y
Q
L
P
Y
Y
D
L
V
P
S
D
P
S
V
E
E
M
R
K
V
V
C
E
Q
K
--
L
R
P
N
I
P
N
-
R
W
Q
S
C
E
A
L
R
V
M
A
K
I
M
R
E
C
W
Y
A
N
G
A
A
R
L
T
A
L
R
I
K
K
T
L
S
Q
L
S
-------
8
PsiBlast_PDB
87.26
64%
-108
- C1 -
2WOT
2
TGFR1_HUMAN
A:
[3-303]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
I
A
R
T
I
V
L
Q
E
S
I
G
K
G
R
F
G
E
V
W
R
G
K
W
R
G
E
E
V
A
V
K
I
F
S
S
R
----
E
E
R
S
W
F
R
E
A
E
I
Y
Q
T
V
M
L
R
H
E
N
I
L
G
F
I
A
A
D
N
K
D
N
G
T
W
T
Q
L
W
L
V
S
D
Y
H
E
H
G
S
L
F
D
Y
L
N
R
--
Y
--
T
V
T
V
E
G
M
I
K
L
A
L
S
T
A
S
G
L
A
H
L
H
M
E
I
---
V
G
T
Q
G
--
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
T
C
C
I
A
D
L
G
L
A
-
V
R
H
D
S
A
T
D
T
I
D
I
A
P
N
H
R
V
G
T
K
R
Y
M
A
P
E
V
L
D
-
D
S
I
N
M
K
H
F
E
--
S
F
-
K
R
A
D
I
Y
A
M
G
L
V
F
W
E
I
A
R
R
C
S
-
I
G
-
G
I
H
E
D
Y
Q
L
P
Y
Y
D
L
V
P
S
D
P
S
V
E
E
M
R
K
V
V
C
E
Q
K
--
L
R
P
N
I
P
N
-
R
W
Q
S
C
E
A
L
R
V
M
A
K
I
M
R
E
C
W
Y
A
N
G
A
A
R
L
T
A
L
R
I
K
K
T
L
S
Q
L
S
Q
Q
E
G
---
11
PsiBlast_PDB
87.00
64%
-111
- C1 -
3TZM
1
TGFR1_HUMAN
A:
[6-302]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
I
A
R
T
I
V
L
Q
E
S
I
G
K
G
R
F
G
E
V
W
R
G
K
W
R
G
E
E
V
A
V
K
I
F
S
S
R
----
E
E
R
S
W
F
R
E
A
E
I
Y
Q
T
V
M
L
R
H
E
N
I
L
G
F
I
A
A
D
N
K
D
N
G
T
W
T
Q
L
W
L
V
S
D
Y
H
E
H
G
S
L
F
D
Y
L
N
R
--
Y
--
T
V
T
V
E
G
M
I
K
L
A
L
S
T
A
S
G
L
A
H
L
H
M
E
I
---
V
G
T
Q
G
--
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
T
C
C
I
A
D
L
G
L
A
-
V
R
H
D
S
A
T
D
T
I
D
I
A
P
--
R
V
G
T
K
R
Y
M
A
P
E
V
L
D
-
D
S
I
N
M
K
H
F
E
--
S
F
-
K
R
A
D
I
Y
A
M
G
L
V
F
W
E
I
A
R
R
C
S
-
I
G
-
G
I
H
E
D
Y
Q
L
P
Y
Y
D
L
V
P
S
D
P
S
V
E
E
M
R
K
V
V
C
E
Q
K
--
L
R
P
N
I
P
N
-
R
W
Q
S
C
E
A
L
R
V
M
A
K
I
M
R
E
C
W
Y
A
N
G
A
A
R
L
T
A
L
R
I
K
K
T
L
S
Q
L
S
-------
7
PsiBlast_PDB
86.57
64%
-112
- C1 -
4C02
11
ACVR1_HUMAN
A:
[9-329]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
T
L
A
D
L
L
D
----
S
G
S
G
S
G
L
P
F
L
V
Q
R
T
V
A
R
Q
I
T
L
L
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
S
W
Q
G
E
N
V
A
V
K
I
F
S
S
R
----
D
E
K
S
W
F
R
E
T
E
L
Y
N
T
V
M
L
R
H
E
N
I
L
G
F
I
A
S
D
M
T
S
R
--
S
T
Q
L
W
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
Q
L
--
T
--
T
L
D
T
V
S
C
L
R
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
I
---
F
G
T
Q
G
--
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
-
V
M
H
S
Q
S
T
N
Q
L
D
V
---
P
R
V
G
T
K
R
Y
M
A
P
E
V
L
D
-
E
T
I
Q
V
D
C
F
D
--
S
Y
-
K
R
V
D
I
W
A
F
G
L
V
L
W
E
V
A
R
R
M
V
-
S
N
-
G
I
V
E
D
Y
K
P
P
F
Y
D
V
V
P
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
--
Q
R
P
N
I
P
N
-
R
W
F
S
D
P
T
L
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
L
R
I
K
K
T
L
T
K
I
D
-------
6
PsiBlast_PDB
86.51
64%
-108
- C1 -
3H9R
4
ACVR1_HUMAN
A:
[6-329]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
G
D
S
T
L
A
D
L
L
D
H
S
C
T
S
G
S
G
S
G
L
P
F
L
V
Q
R
T
V
A
R
Q
I
T
L
L
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
S
W
Q
G
E
N
V
A
V
K
I
F
S
S
R
----
D
E
K
S
W
F
R
E
T
E
L
Y
N
T
V
M
L
R
H
E
N
I
L
G
F
I
A
S
D
M
T
S
---
S
T
Q
L
W
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
Q
L
--
T
--
T
L
D
T
V
S
C
L
R
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
I
---
F
G
T
Q
G
--
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
-
V
M
H
-------------
R
V
G
T
K
R
Y
M
A
P
E
V
L
D
-
E
T
I
Q
V
D
C
F
D
--
S
Y
-
K
R
V
D
I
W
A
F
G
L
V
L
W
E
V
A
R
R
M
V
-
S
N
-
G
I
V
E
D
Y
K
P
P
F
Y
D
V
V
P
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
--
Q
R
P
N
I
P
N
-
R
W
F
S
D
P
T
L
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
L
R
I
K
K
T
L
T
K
I
D
-------
10
PsiBlast_PDB
86.23
64%
-108
- C1 -
4X2G
2
?
A:
[2-303]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
I
A
R
T
I
V
L
Q
E
S
I
G
K
G
R
F
G
E
V
W
R
G
K
W
R
G
E
E
V
A
V
K
I
F
S
S
R
----
E
E
R
S
W
F
R
E
A
E
I
Y
Q
T
V
M
L
R
H
E
N
I
L
G
F
I
A
A
D
N
K
D
N
G
T
W
T
Q
L
W
L
V
S
D
Y
H
E
H
G
S
L
F
D
Y
L
N
R
--
Y
--
T
V
T
V
E
G
M
I
K
L
A
L
S
T
A
S
G
L
A
H
L
H
M
E
I
---
V
G
T
Q
G
--
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
T
C
C
I
A
D
L
G
L
A
-
V
R
H
D
S
A
T
D
T
I
D
I
A
P
N
H
R
V
G
T
K
R
Y
M
A
P
E
V
L
D
-
D
S
I
N
M
K
H
F
E
--
S
F
-
K
R
A
D
I
Y
A
M
G
L
V
F
W
E
I
A
R
R
C
S
-
I
G
-
G
I
H
E
D
Y
Q
L
P
Y
Y
D
L
V
P
S
D
P
S
V
E
E
M
R
K
V
V
C
E
Q
K
--
L
R
P
N
I
P
N
-
R
W
Q
S
C
E
A
L
R
V
M
A
K
I
M
R
E
C
W
Y
A
N
G
A
A
R
L
T
A
L
R
I
K
K
T
L
S
Q
L
S
Q
Q
E
G
I
--
41
PsiBlast_CBE
85.61
64%
-111
- C1 -
4X0M
1
TGFR1_HUMAN
A:
[2-303]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
I
A
R
T
I
V
L
Q
E
S
I
G
K
G
R
F
G
E
V
W
R
G
K
W
R
G
E
E
V
A
V
K
I
F
S
S
R
----
E
E
R
S
W
F
R
E
A
E
I
Y
Q
T
V
M
L
R
H
E
N
I
L
G
F
I
A
A
D
N
K
D
N
G
T
W
T
Q
L
W
L
V
S
D
Y
H
E
H
G
S
L
F
D
Y
L
N
R
--
Y
--
T
V
T
V
E
G
M
I
K
L
A
L
S
T
A
S
G
L
A
H
L
H
M
E
I
---
V
G
T
Q
G
--
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
T
C
C
I
A
D
L
G
L
A
-
V
R
H
D
S
A
T
D
T
I
D
I
A
P
N
H
R
V
G
T
K
R
Y
M
A
P
E
V
L
D
-
D
S
I
N
M
K
H
F
E
--
S
F
-
K
R
A
D
I
Y
A
M
G
L
V
F
W
E
I
A
R
R
C
S
-
I
G
-
G
I
H
E
D
Y
Q
L
P
Y
Y
D
L
V
P
S
D
P
S
V
E
E
M
R
K
V
V
C
E
Q
K
--
L
R
P
N
I
P
N
-
R
W
Q
S
C
E
A
L
R
V
M
A
K
I
M
R
E
C
W
Y
A
N
G
A
A
R
L
T
A
L
R
I
K
K
T
L
S
Q
L
S
Q
Q
E
G
I
--
13
PsiBlast_PDB
85.30
64%
-107
- C1 -
3HMM
1
TGFR1_HUMAN
A:
[1-298]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
A
R
T
I
V
L
Q
E
S
I
G
K
G
R
F
G
E
V
W
R
G
K
W
R
G
E
E
V
A
V
K
I
F
S
S
R
----
E
E
R
S
W
F
R
E
A
E
I
Y
Q
T
V
M
L
R
H
E
N
I
L
G
F
I
A
A
D
N
K
D
N
G
T
W
T
Q
L
W
L
V
S
D
Y
H
E
H
G
S
L
F
D
Y
L
N
R
--
Y
--
T
V
T
V
E
G
M
I
K
L
A
L
S
T
A
S
G
L
A
H
L
H
M
E
I
---
V
G
T
Q
G
--
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
T
C
C
I
A
D
L
G
L
A
-
V
R
H
D
S
A
T
D
T
I
D
I
A
-----
G
T
K
R
Y
M
A
P
E
V
L
D
-
D
S
I
N
M
K
H
F
E
--
S
F
-
K
R
A
D
I
Y
A
M
G
L
V
F
W
E
I
A
R
R
C
S
-
I
G
-
G
I
H
E
D
Y
Q
L
P
Y
Y
D
L
V
P
S
D
P
S
V
E
E
M
R
K
V
V
C
E
Q
K
--
L
R
P
N
I
P
N
-
R
W
Q
S
C
E
A
L
R
V
M
A
K
I
M
R
E
C
W
Y
A
N
G
A
A
R
L
T
A
L
R
I
K
K
T
L
S
Q
L
S
Q
Q
-----
40
PsiBlast_CBE
85.22
64%
-106
- C1 -
4X2J
1
TGFR1_HUMAN
A:
[2-303]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
I
A
R
T
I
V
L
Q
E
S
I
G
K
G
R
F
G
E
V
W
R
G
K
W
R
G
E
E
V
A
V
K
I
F
S
S
R
----
E
E
R
S
W
F
R
E
A
E
I
Y
Q
T
V
M
L
R
H
E
N
I
L
G
F
I
A
A
D
N
K
D
N
G
T
W
T
Q
L
W
L
V
S
D
Y
H
E
H
G
S
L
F
D
Y
L
N
R
--
Y
--
T
V
T
V
E
G
M
I
K
L
A
L
S
T
A
S
G
L
A
H
L
H
M
E
I
---
V
G
T
Q
G
--
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
T
C
C
I
A
D
L
G
L
A
-
V
R
H
D
S
A
T
D
T
I
D
I
A
P
N
H
R
V
G
T
K
R
Y
M
A
P
E
V
L
D
-
D
S
I
N
M
K
H
F
E
--
S
F
-
K
R
A
D
I
Y
A
M
G
L
V
F
W
E
I
A
R
R
C
S
-
I
G
-
G
I
H
E
D
Y
Q
L
P
Y
Y
D
L
V
P
S
D
P
S
V
E
E
M
R
K
V
V
C
E
Q
K
--
L
R
P
N
I
P
N
-
R
W
Q
S
C
E
A
L
R
V
M
A
K
I
M
R
E
C
W
Y
A
N
G
A
A
R
L
T
A
L
R
I
K
K
T
L
S
Q
L
S
Q
Q
E
G
I
--
39
PsiBlast_CBE
85.22
64%
-106
- C1 -
4X2K
1
TGFR1_HUMAN
A:
[2-303]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
I
A
R
T
I
V
L
Q
E
S
I
G
K
G
R
F
G
E
V
W
R
G
K
W
R
G
E
E
V
A
V
K
I
F
S
S
R
----
E
E
R
S
W
F
R
E
A
E
I
Y
Q
T
V
M
L
R
H
E
N
I
L
G
F
I
A
A
D
N
K
D
N
G
T
W
T
Q
L
W
L
V
S
D
Y
H
E
H
G
S
L
F
D
Y
L
N
R
--
Y
--
T
V
T
V
E
G
M
I
K
L
A
L
S
T
A
S
G
L
A
H
L
H
M
E
I
---
V
G
T
Q
G
--
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
T
C
C
I
A
D
L
G
L
A
-
V
R
H
D
S
A
T
D
T
I
D
I
A
P
N
H
R
V
G
T
K
R
Y
M
A
P
E
V
L
D
-
D
S
I
N
M
K
H
F
E
--
S
F
-
K
R
A
D
I
Y
A
M
G
L
V
F
W
E
I
A
R
R
C
S
-
I
G
-
G
I
H
E
D
Y
Q
L
P
Y
Y
D
L
V
P
S
D
P
S
V
E
E
M
R
K
V
V
C
E
Q
K
--
L
R
P
N
I
P
N
-
R
W
Q
S
C
E
A
L
R
V
M
A
K
I
M
R
E
C
W
Y
A
N
G
A
A
R
L
T
A
L
R
I
K
K
T
L
S
Q
L
S
Q
Q
E
G
I
--
12
PsiBlast_PDB
84.97
64%
-107
- C1 -
3GXL
1
TGFR1_HUMAN
A:
[1-298]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
A
R
T
I
V
L
Q
E
S
I
G
K
G
R
F
G
E
V
W
R
G
K
W
---
E
V
A
V
K
I
F
S
S
R
----
E
E
R
S
W
F
R
E
A
E
I
Y
Q
T
V
M
L
R
H
E
N
I
L
G
F
I
A
A
D
N
K
D
N
G
T
W
T
Q
L
W
L
V
S
D
Y
H
E
H
G
S
L
F
D
Y
L
N
R
--
Y
--
T
V
T
V
E
G
M
I
K
L
A
L
S
T
A
S
G
L
A
H
L
H
M
E
I
---
V
G
T
Q
G
--
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
T
C
C
I
A
D
L
G
L
A
-
V
R
H
D
S
A
T
D
T
I
D
-----
R
V
G
T
K
R
Y
M
A
P
E
V
L
D
-
D
S
I
N
M
K
H
F
E
--
S
F
-
K
R
A
D
I
Y
A
M
G
L
V
F
W
E
I
A
R
R
C
S
-
I
----
H
E
D
Y
Q
L
P
Y
Y
D
L
V
P
S
D
P
S
V
E
E
M
R
K
V
V
C
E
Q
K
--
L
R
P
N
I
P
N
-
R
--
S
C
E
A
L
R
V
M
A
K
I
M
R
E
C
W
Y
A
N
G
A
A
R
L
T
A
L
R
I
K
K
T
L
S
Q
L
S
Q
Q
-----
14
PsiBlast_PDB
83.94
64%
-107
- C1 -
1RW8
1
TGFR1_HUMAN
A:
[1-300]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
I
A
R
T
I
V
L
Q
E
S
I
G
K
G
R
F
G
E
V
W
R
G
K
W
R
G
E
E
V
A
V
K
I
F
S
S
R
----
E
E
R
S
W
F
R
E
A
E
I
Y
Q
T
V
M
L
R
H
E
N
I
L
G
F
I
A
A
D
N
K
D
N
G
T
W
T
Q
L
W
L
V
S
D
Y
H
E
H
G
S
L
F
D
Y
L
N
R
--
Y
--
T
V
T
V
E
G
M
I
K
L
A
L
S
T
A
S
G
L
A
H
L
H
M
E
I
---
V
G
T
Q
G
--
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
T
C
C
I
A
D
L
G
L
A
-
V
R
H
D
S
A
T
D
T
I
D
I
A
P
N
H
R
V
G
T
K
R
Y
M
A
P
E
V
L
D
-
D
S
I
N
M
K
H
F
E
--
S
F
-
K
R
A
D
I
Y
A
M
G
L
V
F
W
E
I
A
R
R
C
S
-
I
G
-
G
I
H
E
D
Y
Q
L
P
Y
Y
D
L
V
P
S
D
P
S
V
E
E
M
R
K
V
V
C
E
Q
K
--
L
R
P
N
I
P
N
-
R
W
Q
S
C
E
A
L
R
V
M
A
K
I
M
R
E
C
W
Y
A
N
G
A
A
R
L
T
A
L
R
I
K
K
T
L
S
Q
L
S
Q
Q
E
G
---
47
PsiBlast_CBE
82.97
63%
-106
- C1 -
3Q4U
3
ACVR1_HUMAN
B:
[2-300]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
Q
R
T
V
A
R
D
I
T
L
L
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
S
W
Q
G
E
N
V
A
V
K
I
F
S
S
R
----
D
E
K
S
W
F
R
E
T
E
L
Y
N
T
V
M
L
R
H
E
N
I
L
G
F
I
A
S
D
M
T
S
R
H
S
S
T
Q
L
W
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
Q
L
--
T
--
T
L
D
T
V
S
C
L
R
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
I
---
F
G
T
Q
G
--
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
-
V
M
H
S
Q
S
T
N
Q
L
D
V
G
N
N
P
R
V
G
T
K
R
Y
M
A
P
E
V
L
D
-
E
T
I
Q
V
D
C
F
D
--
S
Y
-
K
R
V
D
I
W
A
F
G
L
V
L
W
E
V
A
R
R
M
V
-
S
N
-
G
I
V
E
D
Y
K
P
P
F
Y
D
V
V
P
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
--
Q
R
P
N
I
P
N
-
R
W
F
S
D
P
T
L
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
L
R
I
K
K
T
L
T
K
I
--------
44
PsiBlast_CBE
81.79
63%
-102
- C1 -
4BGG
1
ACVR1_HUMAN
B:
[5-300]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
V
A
R
D
I
T
L
L
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
S
W
Q
G
E
N
V
A
V
K
I
F
S
S
R
----
D
E
K
S
W
F
R
E
T
E
L
Y
N
T
V
M
L
R
H
E
N
I
L
G
F
I
A
S
D
M
T
S
R
H
S
S
T
Q
L
W
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
Q
L
--
T
--
T
L
D
T
V
S
C
L
R
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
I
---
F
G
-----
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
-
V
M
H
S
Q
S
T
N
Q
L
D
V
G
N
N
P
R
V
G
T
K
R
Y
M
A
P
E
V
L
D
-
E
T
I
Q
V
D
C
F
D
--
S
Y
-
K
R
V
D
I
W
A
F
G
L
V
L
W
E
V
A
R
R
M
V
-
S
N
-
G
I
V
E
D
Y
K
P
P
F
Y
D
V
V
P
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
--
Q
R
P
N
I
P
N
-
R
W
F
S
D
P
T
L
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
L
R
I
K
K
T
L
T
K
I
--------
16
PsiBlast_PDB
81.70
63%
-102
- C1 -
3MTF
12
ACVR1_HUMAN
A:
[5-300]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
V
A
R
D
I
T
L
L
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
S
W
Q
G
E
N
V
A
V
K
I
F
S
S
R
----
D
E
K
S
W
F
R
E
T
E
L
Y
N
T
V
M
L
R
H
E
N
I
L
G
F
I
A
S
D
M
T
S
R
H
S
S
T
Q
L
W
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
Q
L
--
T
--
T
L
D
T
V
S
C
L
R
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
I
---
F
G
T
Q
G
--
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
-
V
M
H
S
Q
S
T
N
Q
L
D
V
G
N
N
P
R
V
G
T
K
R
Y
M
A
P
E
V
L
D
-
E
T
I
Q
V
D
C
F
D
--
S
Y
-
K
R
V
D
I
W
A
F
G
L
V
L
W
E
V
A
R
R
M
V
-
S
N
-
G
I
V
E
D
Y
K
P
P
F
Y
D
V
V
P
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
--
Q
R
P
N
I
P
N
-
R
W
F
S
D
P
T
L
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
L
R
I
K
K
T
L
T
K
I
--------
5
PsiBlast_PDB
81.63
65%
-103
- C1 -
1PY5
1
TGFR1_HUMAN
A:
[26-325]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
I
A
R
T
I
V
L
Q
E
S
I
G
K
G
R
F
G
E
V
W
R
G
K
W
R
G
E
E
V
A
V
K
I
F
S
S
R
----
E
E
R
S
W
F
R
E
A
E
I
Y
Q
T
V
M
L
R
H
E
N
I
L
G
F
I
A
A
D
N
K
D
N
G
T
W
T
Q
L
W
L
V
S
D
Y
H
E
H
G
S
L
F
D
Y
L
N
R
--
Y
--
T
V
T
V
E
G
M
I
K
L
A
L
S
T
A
S
G
L
A
H
L
H
M
E
I
---
V
G
T
Q
G
--
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
T
C
C
I
A
D
L
G
L
A
-
V
R
H
D
S
A
T
D
T
I
D
I
A
P
N
H
R
V
G
T
K
R
Y
M
A
P
E
V
L
D
-
D
S
I
N
M
K
H
F
E
--
S
F
-
K
R
A
D
I
Y
A
M
G
L
V
F
W
E
I
A
R
R
C
S
-
I
G
-
G
I
H
E
D
Y
Q
L
P
Y
Y
D
L
V
P
S
D
P
S
V
E
E
M
R
K
V
V
C
E
Q
K
--
L
R
P
N
I
P
N
-
R
W
Q
S
C
E
A
L
R
V
M
A
K
I
M
R
E
C
W
Y
A
N
G
A
A
R
L
T
A
L
R
I
K
K
T
L
S
Q
L
S
Q
Q
E
G
---
15
PsiBlast_PDB
81.49
63%
-104
- C1 -
4DYM
5
ACVR1_HUMAN
A:
[9-300]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
I
T
L
L
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
S
W
Q
G
E
N
V
A
V
K
I
F
S
S
R
----
D
E
K
S
W
F
R
E
T
E
L
Y
N
T
V
M
L
R
H
E
N
I
L
G
F
I
A
S
D
M
T
S
R
H
S
S
T
Q
L
W
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
Q
L
--
T
--
T
L
D
T
V
S
C
L
R
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
I
---
F
G
T
Q
G
--
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
-
V
M
H
S
Q
S
T
N
Q
L
D
V
G
N
N
P
R
V
G
T
K
R
Y
M
A
P
E
V
L
D
-
E
T
I
Q
V
D
C
F
D
--
S
Y
-
K
R
V
D
I
W
A
F
G
L
V
L
W
E
V
A
R
R
M
V
-
S
N
-
G
I
V
E
D
Y
K
P
P
F
Y
D
V
V
P
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
--
Q
R
P
N
I
P
N
-
R
W
F
S
D
P
T
L
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
L
R
I
K
K
T
L
T
K
I
D
-------
43
PsiBlast_CBE
80.95
63%
-101
- C1 -
4BGG
1
ACVR1_HUMAN
C:
[6-299]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
A
R
D
I
T
L
L
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
S
W
Q
G
E
N
V
A
V
K
I
F
S
S
R
----
D
E
K
S
W
F
R
E
T
E
L
Y
N
T
V
M
L
R
H
E
N
I
L
G
F
I
A
S
D
M
T
S
R
H
S
S
T
Q
L
W
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
Q
L
--
T
--
T
L
D
T
V
S
C
L
R
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
I
-------
G
--
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
-
V
M
H
S
Q
S
T
N
---
V
G
N
N
P
R
V
G
T
K
R
Y
M
A
P
E
V
L
D
-
E
T
I
Q
V
D
C
F
D
--
S
Y
-
K
R
V
D
I
W
A
F
G
L
V
L
W
E
V
A
R
----------
E
D
Y
K
P
P
F
Y
D
V
V
P
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
--
Q
R
P
N
I
P
N
-
R
W
F
S
D
P
T
L
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
L
R
I
K
K
T
L
T
K
---------
19
PsiBlast_PDB
80.75
63%
-101
- C1 -
4BGG
2
ACVR1_HUMAN
A:
[5-300]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
V
A
R
D
I
T
L
L
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
S
W
Q
G
E
N
V
A
V
K
I
F
S
S
R
----
D
E
K
S
W
F
R
E
T
E
L
Y
N
T
V
M
L
R
H
E
N
I
L
G
F
I
A
S
D
M
T
S
R
H
S
S
T
Q
L
W
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
Q
L
--
T
--
T
L
D
T
V
S
C
L
R
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
I
---
F
G
T
Q
G
--
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
-
V
M
H
S
Q
S
T
N
Q
L
D
V
G
N
N
P
R
V
G
T
K
R
Y
M
A
P
E
V
L
D
-
E
T
I
Q
V
D
C
F
D
--
S
Y
-
K
R
V
D
I
W
A
F
G
L
V
L
W
E
V
A
R
R
M
V
-
S
N
-
G
I
V
E
D
Y
K
P
P
F
Y
D
V
V
P
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
--
Q
R
P
N
I
P
N
-
R
W
F
S
D
P
T
L
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
L
R
I
K
K
T
L
T
K
I
--------
139
HHSearch
80.48
63%
-104
- C1 -
3Q4U
7
ACVR1_HUMAN
A:
[4-300]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
T
V
A
R
D
I
T
L
L
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
S
W
Q
G
E
N
V
A
V
K
I
F
S
S
R
----
D
E
K
S
W
F
R
E
T
E
L
Y
N
T
V
M
L
R
H
E
N
I
L
G
F
I
A
S
D
M
T
S
R
H
S
S
T
Q
L
W
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
Q
L
--
T
--
T
L
D
T
V
S
C
L
R
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
I
---
F
G
T
Q
G
--
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
-
V
M
H
S
Q
S
T
N
Q
L
D
V
G
N
N
P
R
V
G
T
K
R
Y
M
A
P
E
V
L
D
-
E
T
I
Q
V
D
C
F
D
--
S
Y
-
K
R
V
D
I
W
A
F
G
L
V
L
W
E
V
A
R
R
M
V
-
S
N
-
G
I
V
E
D
Y
K
P
P
F
Y
D
V
V
P
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
--
Q
R
P
N
I
P
N
-
R
W
F
S
D
P
T
L
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
L
R
I
K
K
T
L
T
K
I
D
-------
18
PsiBlast_PDB
80.48
63%
-104
- C1 -
3Q4U
7
ACVR1_HUMAN
A:
[4-300]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
T
V
A
R
D
I
T
L
L
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
S
W
Q
G
E
N
V
A
V
K
I
F
S
S
R
----
D
E
K
S
W
F
R
E
T
E
L
Y
N
T
V
M
L
R
H
E
N
I
L
G
F
I
A
S
D
M
T
S
R
H
S
S
T
Q
L
W
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
Q
L
--
T
--
T
L
D
T
V
S
C
L
R
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
I
---
F
G
T
Q
G
--
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
-
V
M
H
S
Q
S
T
N
Q
L
D
V
G
N
N
P
R
V
G
T
K
R
Y
M
A
P
E
V
L
D
-
E
T
I
Q
V
D
C
F
D
--
S
Y
-
K
R
V
D
I
W
A
F
G
L
V
L
W
E
V
A
R
R
M
V
-
S
N
-
G
I
V
E
D
Y
K
P
P
F
Y
D
V
V
P
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
--
Q
R
P
N
I
P
N
-
R
W
F
S
D
P
T
L
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
L
R
I
K
K
T
L
T
K
I
D
-------
17
PsiBlast_PDB
80.47
63%
-101
- C1 -
3OOM
16
ACVR1_HUMAN
A:
[5-300]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
V
A
R
D
I
T
L
L
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
S
W
Q
G
E
N
V
A
V
K
I
F
S
S
R
----
D
E
K
S
W
F
R
E
T
E
L
Y
N
T
V
M
L
R
H
E
N
I
L
G
F
I
A
S
D
M
T
S
R
H
S
S
T
Q
L
W
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
Q
L
--
T
--
T
L
D
T
V
S
C
L
R
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
I
---
F
G
T
Q
G
--
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
-
V
M
H
S
Q
S
T
N
Q
L
D
V
G
N
N
P
R
V
G
T
K
R
Y
M
A
P
E
V
L
D
-
E
T
I
Q
V
D
C
F
D
--
S
Y
-
K
R
V
D
I
W
A
F
G
L
V
L
W
E
V
A
R
R
M
V
-
S
N
-
G
I
V
E
D
Y
K
P
P
F
Y
D
V
V
P
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
--
Q
R
P
N
I
P
N
-
R
W
F
S
D
P
T
L
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
L
R
I
K
K
T
L
T
K
I
D
-------
46
PsiBlast_CBE
80.31
63%
-101
- C1 -
3Q4U
6
ACVR1_HUMAN
C:
[6-300]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
A
R
D
I
T
L
L
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
S
W
Q
G
E
N
V
A
V
K
I
F
S
S
R
----
D
E
K
S
W
F
R
E
T
E
L
Y
N
T
V
M
L
R
H
E
N
I
L
G
F
I
A
S
D
M
T
S
R
H
S
S
T
Q
L
W
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
Q
L
--
T
--
T
L
D
T
V
S
C
L
R
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
I
---
F
G
T
Q
G
--
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
-
V
M
H
S
Q
S
T
N
Q
L
D
V
G
N
N
P
R
V
G
T
K
R
Y
M
A
P
E
V
L
D
-
E
T
I
Q
V
D
C
F
D
--
S
Y
-
K
R
V
D
I
W
A
F
G
L
V
L
W
E
V
A
R
R
M
V
-
S
N
-
G
I
V
E
D
Y
K
P
P
F
Y
D
V
V
P
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
--
Q
R
P
N
I
P
N
-
R
W
F
S
D
P
T
L
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
L
R
I
K
K
T
L
T
K
I
D
-------
42
PsiBlast_CBE
80.30
63%
-102
- C1 -
4BGG
1
ACVR1_HUMAN
D:
[6-300]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
A
R
D
I
T
L
L
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
S
W
Q
G
E
N
V
A
V
K
I
F
S
S
R
----
D
E
K
S
W
F
R
E
T
E
L
Y
N
T
V
M
L
R
H
E
N
I
L
G
F
I
A
S
D
M
T
------
Q
L
W
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
Q
L
--
T
--
T
L
D
T
V
S
C
L
R
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
I
---
F
G
-----
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
-
V
M
H
S
Q
S
T
N
Q
L
D
V
G
N
N
P
R
V
G
T
K
R
Y
M
A
P
E
V
L
D
-
E
T
I
Q
V
D
C
F
D
--
S
Y
-
K
R
V
D
I
W
A
F
G
L
V
L
W
E
V
A
R
R
M
V
-
S
N
-
G
I
V
E
D
Y
K
P
P
F
Y
D
V
V
P
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
--
Q
R
P
N
I
P
N
-
R
W
F
S
D
P
T
L
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
L
R
I
K
K
T
L
T
K
I
--------
71
PsiBlast_CBE
73.78
41%
-104
- C1 -
4ASX
4
AVR2A_HUMAN
A:
[26-316]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
Q
L
L
E
V
K
A
R
G
R
F
G
C
V
W
K
A
Q
L
L
N
E
Y
V
A
V
K
I
F
P
I
Q
----
D
K
Q
S
W
Q
N
E
Y
E
V
Y
S
L
P
G
M
K
H
E
N
I
L
Q
F
I
G
A
E
K
R
G
T
S
V
D
V
D
L
W
L
I
T
A
F
H
E
K
G
S
L
S
D
F
L
K
A
--
N
--
V
V
S
W
N
E
L
C
H
I
A
E
T
M
A
R
G
L
A
Y
L
H
E
D
I
---
P
G
L
K
D
GH
K
P
A
I
S
H
R
D
I
K
S
K
N
V
L
L
K
N
N
L
T
A
C
I
A
D
F
G
L
A
-
L
K
F
E
A
G
K
S
A
G
-
T
--
H
G
Q
V
G
T
R
R
Y
M
A
P
E
V
L
E
-
G
A
I
N
---
F
Q
R
D
A
F
-
L
R
I
D
M
Y
A
M
G
L
V
L
W
E
L
A
S
R
C
T
-
A
A
D
G
P
V
D
E
Y
M
L
P
F
E
E
E
I
G
Q
H
P
S
L
E
D
M
Q
E
V
V
V
H
K
K
--
K
R
P
V
L
R
D
-
Y
W
Q
K
H
A
G
M
A
M
L
C
E
T
I
E
E
C
W
D
H
D
A
E
A
R
L
S
A
G
C
V
G
E
R
I
T
Q
M
Q
R
L
T
----
74
PsiBlast_CBE
72.93
41%
-106
- C1 -
3Q4T
9
AVR2A_HUMAN
B:
[26-316]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
Q
L
L
E
V
K
A
R
G
R
F
G
C
V
W
K
A
Q
L
L
N
E
Y
V
A
V
K
I
F
P
I
Q
----
D
K
Q
S
W
Q
N
E
Y
E
V
Y
S
L
P
G
M
K
H
E
N
I
L
Q
F
I
G
A
E
K
R
G
T
S
V
D
V
D
L
W
L
I
T
A
F
H
E
K
G
S
L
S
D
F
L
K
A
--
N
--
V
V
S
W
N
E
L
C
H
I
A
E
T
M
A
R
G
L
A
Y
L
H
E
D
I
---
P
G
L
K
D
GH
K
P
A
I
S
H
R
D
I
K
S
K
N
V
L
L
K
N
N
L
T
A
C
I
A
D
F
G
L
A
-
L
K
F
E
A
G
K
S
A
--
T
--
H
G
Q
V
G
T
R
R
Y
M
A
P
E
V
L
E
-
G
A
I
N
---
F
Q
R
D
A
F
-
L
R
I
D
M
Y
A
M
G
L
V
L
W
E
L
A
S
R
C
T
-
A
A
D
G
P
V
D
E
Y
M
L
P
F
E
E
E
I
G
Q
H
P
S
L
E
D
M
Q
E
V
V
V
H
K
K
--
K
R
P
V
L
R
D
-
Y
W
Q
K
H
A
G
M
A
M
L
C
E
T
I
E
E
C
W
D
H
D
A
E
A
R
L
S
A
G
C
V
G
E
R
I
T
Q
M
Q
R
L
-----
75
PsiBlast_CBE
72.73
41%
-103
- C1 -
3Q4T
13
AVR2A_HUMAN
A:
[26-316]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
Q
L
L
E
V
K
A
R
G
R
F
G
C
V
W
K
A
Q
L
L
N
E
Y
V
A
V
K
I
F
P
I
Q
----
D
K
Q
S
W
Q
N
E
Y
E
V
Y
S
L
P
G
M
K
H
E
N
I
L
Q
F
I
G
A
E
K
R
G
T
S
V
D
V
D
L
W
L
I
T
A
F
H
E
K
G
S
L
S
D
F
L
K
A
--
N
--
V
V
S
W
N
E
L
C
H
I
A
E
T
M
A
R
G
L
A
Y
L
H
E
D
I
---
P
G
L
K
D
GH
K
P
A
I
S
H
R
D
I
K
S
K
N
V
L
L
K
N
N
L
T
A
C
I
A
D
F
G
L
A
-
L
K
F
E
A
G
K
S
A
G
D
T
--
H
G
Q
V
G
T
R
R
Y
M
A
P
E
V
L
E
-
G
A
I
N
---
F
Q
R
D
A
F
-
L
R
I
D
M
Y
A
M
G
L
V
L
W
E
L
A
S
R
C
T
-
A
A
D
G
P
V
D
E
Y
M
L
P
F
E
E
E
I
G
Q
H
P
S
L
E
D
M
Q
E
V
V
V
H
K
K
--
K
R
P
V
L
R
D
-
Y
W
Q
K
H
A
G
M
A
M
L
C
E
T
I
E
E
C
W
D
H
D
A
E
A
R
L
S
A
G
C
V
G
E
R
I
T
Q
M
Q
R
------
72
PsiBlast_CBE
72.52
41%
-103
- C1 -
3SOC
5
AVR2A_HUMAN
B:
[26-316]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
Q
L
L
E
V
K
A
R
G
R
F
G
C
V
W
K
A
Q
L
L
N
E
Y
V
A
V
K
I
F
P
I
Q
----
D
K
Q
S
W
Q
N
E
Y
E
V
Y
S
L
P
G
M
K
H
E
N
I
L
Q
F
I
G
A
E
K
R
G
T
S
V
D
V
D
L
W
L
I
T
A
F
H
E
K
G
S
L
S
D
F
L
K
A
--
N
--
V
V
S
W
N
E
L
C
H
I
A
E
T
M
A
R
G
L
A
Y
L
H
E
D
I
---
P
G
L
K
D
GH
K
P
A
I
S
H
R
D
I
K
S
K
N
V
L
L
K
N
N
L
T
A
C
I
A
D
F
G
L
A
-
L
K
F
E
A
G
K
S
A
--
T
--
H
G
Q
V
G
T
R
R
Y
M
A
P
E
V
L
E
-
G
A
I
N
---
F
Q
R
D
A
F
-
L
R
I
D
M
Y
A
M
G
L
V
L
W
E
L
A
S
R
C
T
-
A
A
D
G
P
V
D
E
Y
M
L
P
F
E
E
E
I
G
Q
H
P
S
L
E
D
M
Q
E
V
V
V
H
K
K
--
K
R
P
V
L
R
D
-
Y
W
Q
K
H
A
G
M
A
M
L
C
E
T
I
E
E
C
W
D
H
D
A
E
A
R
L
S
A
G
C
V
G
E
R
I
T
Q
M
Q
R
L
T
----
70
PsiBlast_CBE
72.22
41%
-99
- C1 -
4ASX
6
AVR2A_HUMAN
B:
[26-316]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
Q
L
L
E
V
K
A
R
G
R
F
G
C
V
W
K
A
Q
L
L
N
E
Y
V
A
V
K
I
F
P
I
Q
----
D
K
Q
S
W
Q
N
E
Y
E
V
Y
S
L
P
G
M
K
H
E
N
I
L
Q
F
I
G
A
E
K
R
G
T
S
V
D
V
D
L
W
L
I
T
A
F
H
E
K
G
S
L
S
D
F
L
K
A
--
N
--
V
V
S
W
N
E
L
C
H
I
A
E
T
M
A
R
G
L
A
Y
L
H
E
D
I
---
P
G
L
K
D
GH
K
P
A
I
S
H
R
D
I
K
S
K
N
V
L
L
K
N
N
L
T
A
C
I
A
D
F
G
L
A
-
L
K
F
E
A
G
K
S
A
G
D
T
--
H
G
Q
V
G
T
R
R
Y
M
A
P
E
V
L
E
-
G
A
I
N
---
F
Q
R
D
A
F
-
L
R
I
D
M
Y
A
M
G
L
V
L
W
E
L
A
S
R
C
T
-
A
A
D
G
P
V
D
E
Y
M
L
P
F
E
E
E
I
G
Q
H
P
S
L
E
D
M
Q
E
V
V
V
H
K
K
--
K
R
P
V
L
R
D
-
Y
W
Q
K
H
A
G
M
A
M
L
C
E
T
I
E
E
C
W
D
H
D
A
E
A
R
L
S
A
G
C
V
G
E
R
I
T
Q
M
Q
R
L
T
----
73
PsiBlast_CBE
70.07
41%
-99
- C1 -
3SOC
7
AVR2A_HUMAN
A:
[26-316]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
Q
L
L
E
V
K
A
R
G
R
F
G
C
V
W
K
A
Q
L
L
N
E
Y
V
A
V
K
I
F
P
I
Q
----
D
K
Q
S
W
Q
N
E
Y
E
V
Y
S
L
P
G
M
K
H
E
N
I
L
Q
F
I
G
A
E
K
R
G
T
S
V
D
V
D
L
W
L
I
T
A
F
H
E
K
G
S
L
S
D
F
L
K
A
--
N
--
V
V
S
W
N
E
L
C
H
I
A
E
T
M
A
R
G
L
A
Y
L
H
E
D
I
---
P
G
L
K
D
GH
K
P
A
I
S
H
R
D
I
K
S
K
N
V
L
L
K
N
N
L
T
A
C
I
A
D
F
G
L
A
-
L
K
F
E
A
G
K
S
A
G
D
T
--
H
G
Q
V
G
T
R
R
Y
M
A
P
E
V
L
E
-
G
A
I
N
---
F
Q
R
D
A
F
-
L
R
I
D
M
Y
A
M
G
L
V
L
W
E
L
A
S
R
C
T
-
A
A
D
G
P
V
D
E
Y
M
L
P
F
E
E
E
I
G
Q
H
P
S
L
E
D
M
Q
E
V
V
V
H
K
K
--
K
R
P
V
L
R
D
-
Y
W
Q
K
H
A
G
M
A
M
L
C
E
T
I
E
E
C
W
D
H
D
A
E
A
R
L
S
A
G
C
V
G
E
R
I
T
Q
M
Q
R
L
T
----
141
HHSearch
69.14
41%
-92
- C1 -
3SOC
7
AVR2A_HUMAN
A:
[25-320]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
L
Q
L
L
E
V
K
A
R
G
R
F
G
C
V
W
K
A
Q
L
L
N
E
Y
V
A
V
K
I
F
P
I
Q
----
D
K
Q
S
W
Q
N
E
Y
E
V
Y
S
L
P
G
M
K
H
E
N
I
L
Q
F
I
G
A
E
K
R
G
T
S
V
D
V
D
L
W
L
I
T
A
F
H
E
K
G
S
L
S
D
F
L
K
A
--
N
--
V
V
S
W
N
E
L
C
H
I
A
E
T
M
A
R
G
L
A
Y
L
H
E
D
I
---
P
G
L
K
D
GH
K
P
A
I
S
H
R
D
I
K
S
K
N
V
L
L
K
N
N
L
T
A
C
I
A
D
F
G
L
A
-
L
K
F
E
A
G
K
S
A
--
G
D
T
H
G
Q
V
G
T
R
R
Y
M
A
P
E
V
L
E
-
G
A
I
N
F
Q
-
R
D
--
A
F
-
L
R
I
D
M
Y
A
M
G
L
V
L
W
E
L
A
S
R
C
T
A
A
D
-
G
P
V
D
E
Y
M
L
P
F
E
E
E
I
G
Q
H
P
S
L
E
D
M
Q
E
V
V
V
H
K
K
--
K
R
P
V
L
R
D
-
Y
W
Q
K
H
A
G
M
A
M
L
C
E
T
I
E
E
C
W
D
H
D
A
E
A
R
L
S
A
G
C
V
G
E
R
I
T
Q
M
Q
R
L
T
----
76
PsiBlast_CBE
66.31
39%
-96
- C1 -
2QLU
1
AVR2B_HUMAN
A:
[17-298]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
Q
L
L
E
I
K
A
R
G
R
F
G
C
V
W
K
A
Q
L
M
N
D
F
V
A
V
K
I
F
P
L
Q
----
D
K
Q
S
W
Q
S
E
R
E
I
F
S
T
P
G
M
K
H
E
N
L
L
Q
F
I
A
A
E
K
R
G
S
N
L
E
V
E
L
W
L
I
T
A
F
H
D
K
G
S
L
T
D
Y
L
K
G
--
N
--
I
I
T
W
N
E
L
C
H
V
A
E
T
M
S
R
G
L
S
Y
L
H
E
D
V
PWC
R
G
E
G
H
--
K
P
S
I
A
H
R
D
F
K
S
K
N
V
L
L
K
S
D
L
T
A
V
L
A
D
F
G
L
A
-
V
R
F
E
P
G
K
P
P
G
D
T
--
H
G
Q
V
G
T
R
R
Y
M
A
P
E
V
L
E
-
G
A
I
N
---
F
Q
R
D
A
F
-
L
R
I
D
M
Y
A
M
G
L
V
L
W
E
L
V
S
R
C
K
-
A
A
D
G
P
V
D
E
Y
M
L
P
F
E
E
E
I
G
Q
H
P
S
L
E
E
L
Q
E
V
V
V
H
K
K
--
M
R
P
T
I
K
D
-
H
W
L
K
H
P
G
L
A
Q
L
C
V
T
I
E
E
C
W
D
H
D
A
E
A
R
L
S
A
G
C
V
E
E
R
V
S
L
I
R
R
S
-----
125
PsiBlast_CBE
60.84
31%
-111
- C1 -
3PPK
1
B:
[37-277]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
D
-
V
A
V
K
M
L
N
V
T
APT
P
Q
Q
L
Q
A
F
K
-
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
T
K
-----
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
IE
T
--
K
F
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
-------------
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
T
V
------------
L
S
---
G
S
I
L
W
M
A
P
E
V
I
--
R
M
Q
D
K
N
-----
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
----
M
-
T
G
-------
Q
L
P
Y
S
N
I
N
N
R
D
------
Q
I
I
F
M
V
G
R
GY
L
S
P
D
L
S
K
---
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
P
K
--
123
PsiBlast_CBE
59.43
31%
-108
- C1 -
3PRF
1
B:
[37-277]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
D
-
V
A
V
K
M
L
N
V
T
APTP
Q
Q
L
Q
A
F
K
-
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
T
K
-----
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
IE
T
--
K
F
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
-------------
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
T
V
-----------------
G
S
I
L
W
M
A
P
E
V
I
--
R
M
Q
D
K
N
-----
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
----
M
-
T
G
-------
Q
L
P
Y
S
N
I
N
N
R
D
------
Q
I
I
F
M
V
G
R
GY
L
S
P
D
L
S
K
---
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
P
K
--
81
PsiBlast_CBE
59.28
31%
-105
- C1 -
4JVG
1
D:
[17-271]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
D
-
V
A
V
K
M
L
N
V
T
APTP
Q
Q
L
Q
A
F
K
-
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
T
K
-----
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
A
--
S
ET
K
F
E
M
K
K
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
A
K
-------------
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
N
T
V
K
I
G
D
F
G
L
A
T
V
K
S
----------------
S
I
L
W
M
A
P
E
V
I
R
M
Q
D
S
N
P
Y
S
F
Q
-------
S
D
V
Y
A
F
G
I
V
L
Y
E
L
----
M
-
T
G
-------
Q
L
P
Y
S
N
I
N
N
R
D
----
Q
I
I
E
M
V
G
R
G
S
--
L
S
P
D
L
S
K
V
R
S
N
---
C
P
K
R
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
S
F
P
R
I
L
A
E
I
E
E
L
A
R
E
L
S
---
118
PsiBlast_CBE
58.87
31%
-105
- C1 -
3PSD
1
BRAF_HUMAN
A:
[37-277]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
D
-
V
A
V
K
M
L
N
V
T
APT
P
Q
Q
L
Q
A
F
K
-
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
T
K
-----
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
IE
T
--
K
F
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
-------------
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
T
V
-----------------
G
S
I
L
W
M
A
P
E
V
I
--
R
M
Q
D
K
N
-----
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
----
M
-
T
G
-------
Q
L
P
Y
S
N
I
N
N
R
D
------
Q
I
I
F
M
V
G
R
GY
L
S
P
D
L
S
K
---
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
P
K
--
77
PsiBlast_CBE
58.06
31%
-103
- C1 -
4WO5
1
B:
[33-287]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
D
-
V
A
V
K
M
L
N
V
T
APT
P
Q
Q
L
Q
A
F
K
-
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
T
K
-----
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
A
--
S
E
T
K
F
E
M
K
K
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
A
K
-------------
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
N
T
V
K
I
G
D
F
G
L
A
T------------------
G
S
I
L
W
M
A
P
E
V
I
R
M
Q
D
S
N
P
Y
S
F
Q
-------
S
D
V
Y
A
F
G
I
V
L
Y
E
L
----
M
-
T
G
-------
Q
L
P
Y
S
N
I
N
N
R
D
----
Q
I
I
E
M
V
G
R
G
S
--
L
S
P
D
L
S
K
V
R
S
N
---
C
P
K
R
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
S
F
P
R
I
L
A
E
I
E
E
L
A
R
E
L
----
83
PsiBlast_CBE
57.68
31%
-105
- C1 -
4JVG
1
BRAF_HUMAN
B:
[17-271]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
D
-
V
A
V
K
M
L
N
V
T
APT
P
Q
Q
L
Q
A
F
K
-
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
T
K
-----
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
A
--
S
E
T
K
F
E
M
K
K
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
A
K
-------------
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
N
T
V
K
I
G
D
F
G
L
A
T-------------------
S
I
L
W
M
A
P
E
V
I
R
M
Q
D
S
N
P
Y
S
F
Q
-------
S
D
V
Y
A
F
G
I
V
L
Y
E
L
----
M
-
T
G
-------
Q
L
P
Y
S
N
I
N
N
R
D
----
Q
I
I
E
M
V
G
R
G
S
--
L
S
P
D
L
S
K
V
R
S
N
---
C
P
K
R
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
S
F
P
R
I
L
A
E
I
E
E
L
A
R
E
L
S
---
79
PsiBlast_CBE
57.39
31%
-102
- C1 -
3C4C
1
B:
[13-267]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
D
-
V
A
V
K
M
L
N
V
T
APT
P
Q
Q
L
Q
A
F
K
-
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
T
K
-----
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
A
--
S
ET
K
F
E
M
K
K
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
A
K
-------------
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
N
T
V
K
I
G
D
F
------------------
S
---
G
S
I
L
W
M
A
P
E
V
I
R
M
Q
D
S
N
P
Y
S
F
Q
-------
S
D
V
Y
A
F
G
I
V
L
Y
E
L
----
M
-
T
G
-------
Q
L
P
Y
S
N
I
N
N
R
D
----
Q
I
I
E
M
V
G
R
G
S
--
L
S
P
D
L
S
K
V
R
S
N
---
C
P
K
R
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
S
F
P
R
I
L
A
E
I
E
E
L
A
R
E
L
S
---
120
PsiBlast_CBE
57.34
31%
-109
- C1 -
3PSB
1
BRAF_HUMAN
A:
[37-277]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
D
-
V
A
V
K
M
L
N
V
T
APT
P
Q
Q
L
Q
A
F
K
-
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
T
K
-----
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
IE
T
--
K
F
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
-------------
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
T
V
-----------------
G
S
I
L
W
M
A
P
E
V
I
--
R
M
Q
D
K
N
-----
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
----
M
-
T
G
-------
Q
L
P
Y
S
N
I
N
N
R
D
------
Q
I
I
F
M
V
G
R
GY
L
S
P
D
L
S
K
---
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
P
K
--
87
PsiBlast_CBE
57.19
31%
-111
- C1 -
5CT7
1
?
B:
[14-254]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
D
-
V
A
V
K
M
L
N
V
T
APT
P
Q
Q
L
Q
A
F
K
-
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
T
K
-----
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
IE
T
--
K
F
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
-------------
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
----------------------
G
S
I
L
W
M
A
P
E
V
I
R
-
M
Q
-
D
K
N
-----
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
----
M
-
T
G
-------
Q
L
P
Y
S
N
I
N
N
R
D
------
Q
I
I
F
M
V
G
R
GY
L
S
P
D
L
S
K
-
V
--
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
----
86
PsiBlast_CBE
56.77
31%
-108
- C1 -
4MNF
1
BRAF_HUMAN
A:
[49-289]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
D
-
V
A
V
K
M
L
N
V
T
APT
P
Q
Q
L
Q
A
F
K
-
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
T
K
-----
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
IE
T
--
K
F
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
-------------
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
-
T
E
-----------------
S
I
L
W
M
A
P
E
V
I
--
R
M
Q
D
K
N
-----
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
----
M
-
T
G
-------
Q
L
P
Y
S
N
I
N
N
R
D
------
Q
I
I
F
M
V
G
R
GY
L
S
P
D
L
S
K
V
R
S
N
---
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
-----
85
PsiBlast_CBE
56.58
31%
-107
- C1 -
4MNF
1
B:
[49-289]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
D
-
V
A
V
K
M
L
N
V
T
APTP
Q
Q
L
Q
A
F
K
-
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
T
K
-----
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
IE
T
--
K
F
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
-------------
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
-
T
E
-----------------
S
I
L
W
M
A
P
E
V
I
--
R
M
Q
D
K
N
-----
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
----
M
-
T
G
-------
Q
L
P
Y
S
N
I
N
N
R
D
------
Q
I
I
F
M
V
G
R
GY
L
S
P
D
L
S
K
V
R
S
N
---
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
-----
94
PsiBlast_CBE
56.47
31%
-107
- C1 -
4MBJ
1
BRAF_HUMAN
A:
[37-277]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
D
-
V
A
V
K
M
L
N
V
T
APTP
Q
Q
L
Q
A
F
K
-
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
T
K
-----
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
IE
T
--
K
F
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
-------------
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
T
V
K
S
R
W
S
-------
L
S
---
G
S
I
L
W
M
A
P
E
V
I
--
R
M
Q
D
K
N
-----
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
----
M
-
T
G
-------
Q
L
P
Y
S
N
I
N
N
R
D
------
Q
I
I
F
M
V
G
R
GY
L
S
P
D
L
S
K
-
V
--
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
P
K
--
97
PsiBlast_CBE
56.30
31%
-106
- C1 -
1UWH
1
B:
[9-249]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
D
-
V
A
V
K
M
L
N
V
T
APTP
Q
Q
L
Q
A
F
K
-
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
-----
G
Y
S
T
A
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
IE
T
--
K
F
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
-------------
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
T
V
------------
L
S
---
G
S
I
L
W
M
A
P
E
V
I
R
-
M
Q
-
D
K
N
-----
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
----
M
-
T
G
-------
Q
L
P
Y
S
N
I
N
N
R
D
------
Q
I
I
F
M
V
G
R
GY
L
S
P
D
L
S
K
-
V
--
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
P
K
--
117
PsiBlast_CBE
56.24
31%
-102
- C1 -
3PSD
1
B:
[37-277]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
D
-
V
A
V
K
M
L
N
V
T
APT
P
Q
Q
L
Q
A
F
K
-
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
T
K
-----
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
IE
T
--
K
F
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
-------------
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
T
V
------------
L
S
---
G
S
I
L
W
M
A
P
E
V
I
--
R
M
Q
D
K
N
-----
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
----
M
-
T
G
-------
Q
L
P
Y
S
N
I
N
N
R
D
------
Q
I
I
F
M
V
G
R
GY
L
S
P
D
L
S
K
---
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
P
K
--
105
PsiBlast_CBE
56.20
31%
-106
- C1 -
4EHE
1
BRAF_HUMAN
A:
[37-277]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
D
-
V
A
V
K
M
L
N
V
T
APTP
Q
Q
L
Q
A
F
K
-
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
T
K
-----
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
IE
T
--
K
F
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
-------------
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
T
V
K
S
R
----------
S
---
G
S
I
L
W
M
A
P
E
V
I
--
R
M
Q
D
K
N
-----
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
----
M
-
T
G
-------
Q
L
P
Y
S
N
I
N
N
R
D
------
Q
I
I
F
M
V
G
R
GY
L
S
P
D
L
S
K
---
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
P
K
--
98
PsiBlast_CBE
56.05
31%
-104
- C1 -
1UWH
1
BRAF_HUMAN
A:
[9-249]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
D
-
V
A
V
K
M
L
N
V
T
APT
P
Q
Q
L
Q
A
F
K
-
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
-----
G
Y
S
T
A
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
IE
T
--
K
F
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
-------------
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
T
V
------------
L
S
---
G
S
I
L
W
M
A
P
E
V
I
R
-
M
Q
-
D
K
N
-----
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
----
M
-
T
G
-------
Q
L
P
Y
S
N
I
N
N
R
D
------
Q
I
I
F
M
V
G
R
GY
L
S
P
D
L
S
K
-
V
--
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
P
K
--
88
PsiBlast_CBE
56.00
31%
-110
- C1 -
5CT7
1
?
A:
[14-254]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
D
-
V
A
V
K
M
L
N
V
T
APT
P
Q
Q
L
Q
A
F
K
-
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
T
K
-----
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
IE
T
--
K
F
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
-------------
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
-------------------
G
S
I
L
W
M
A
P
E
V
I
R
-
M
Q
-
D
K
N
-----
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
----
M
-
T
G
-------
Q
L
P
Y
S
N
I
N
N
R
D
------
Q
I
I
F
M
V
G
R
GY
L
S
P
D
L
S
K
-
V
--
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
----
93
PsiBlast_CBE
55.98
31%
-103
- C1 -
4MBJ
1
B:
[37-277]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
D
-
V
A
V
K
M
L
N
V
T
APTP
Q
Q
L
Q
A
F
K
-
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
T
K
-----
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
IE
T
--
K
F
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
-------------
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
T
V
K
S
R
W
S
G
S
H
Q
F
E
Q
L
S
---
G
S
I
L
W
M
A
P
E
V
I
--
R
M
Q
D
K
N
-----
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
----
M
-
T
G
-------
Q
L
P
Y
S
N
I
N
N
R
D
------
Q
I
I
F
M
V
G
R
GY
L
S
P
D
L
S
K
-
V
--
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
P
K
--
119
PsiBlast_CBE
55.96
31%
-103
- C1 -
3PSB
1
B:
[37-277]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
D
-
V
A
V
K
M
L
N
V
T
APT
P
Q
Q
L
Q
A
F
K
-
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
T
K
-----
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
IE
T
--
K
F
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
-------------
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
T
V
------------
L
S
---
G
S
I
L
W
M
A
P
E
V
I
--
R
M
Q
D
K
N
-----
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
----
M
-
T
G
-------
Q
L
P
Y
S
N
I
N
N
R
D
------
Q
I
I
F
M
V
G
R
GY
L
S
P
D
L
S
K
---
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
P
K
--
109
PsiBlast_CBE
55.73
31%
-105
- C1 -
4E26
1
BRAF_HUMAN
A:
[37-277]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
D
-
V
A
V
K
M
L
N
V
T
APT
P
Q
Q
L
Q
A
F
K
-
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
T
K
-----
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
IE
T
--
K
F
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
-------------
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
T
V
K
S
R
------
F
E
Q
L
S
---
G
S
I
L
W
M
A
P
E
V
I
--
R
M
Q
D
K
N
-----
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
----
M
-
T
G
-------
Q
L
P
Y
S
N
I
N
N
R
D
------
Q
I
I
F
M
V
G
R
GY
L
S
P
D
L
S
K
---
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
P
K
--
82
PsiBlast_CBE
55.62
31%
-104
- C1 -
4JVG
1
BRAF_HUMAN
C:
[17-271]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
D
-
V
A
V
K
M
L
N
V
T
APT
P
Q
Q
L
Q
A
F
K
-
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
T
K
-----
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
A
--
S
E
T
K
F
E
M
K
K
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
A
K
-------------
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
N
T
V
K
I
G
D
F
G
L
A
--------------------
S
I
L
W
M
A
P
E
V
I
R
M
Q
D
S
N
P
Y
S
F
Q
-------
S
D
V
Y
A
F
G
I
V
L
Y
E
L
----
M
-
T
G
-------
Q
L
P
Y
S
N
I
N
N
R
D
----
Q
I
I
E
M
V
G
R
G
S
--
L
S
P
D
L
S
K
V
R
S
N
---
C
P
K
R
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
S
F
P
R
I
L
A
E
I
E
E
L
A
R
E
L
S
---
107
PsiBlast_CBE
55.60
31%
-105
- C1 -
4E4X
1
BRAF_HUMAN
A:
[37-277]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
D
-
V
A
V
K
M
L
N
V
T
APT
P
Q
Q
L
Q
A
F
K
-
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
T
K
-----
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
IE
T
--
K
F
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
-------------
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
T
V
K
S
R
W
S
-------
L
S
---
G
S
I
L
W
M
A
P
E
V
I
--
R
M
Q
D
K
N
-----
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
----
M
-
T
G
-------
Q
L
P
Y
S
N
I
N
N
R
D
------
Q
I
I
F
M
V
G
R
GY
L
S
P
D
L
S
K
---
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
----
78
PsiBlast_CBE
55.38
31%
-97
- C1 -
4WO5
1
BRAF_HUMAN
A:
[33-287]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
D
-
V
A
V
K
M
L
N
V
T
APT
P
Q
Q
L
Q
A
F
K
-
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
T
K
-----
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
A
--
S
E-
K
F
E
M
K
K
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
A
K
-------------
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
N
T
V
K
I
G
D
F
G
L
A
T
V
K
S
R
W
S
----
F
E
Q
L
S
---
G
S
I
L
W
M
A
P
E
V
I
R
M---
N
P
Y
S
F
Q
-------
S
D
V
Y
A
F
G
I
V
L
Y
E
L
----
M
-
T
G
-------
Q
L
P
Y
S
N
I
N
N
R
D
----
Q
I
I
E
M
V
G
R
G
S
--
L
S
P
D
L
S
K
V
R
S
N
---
C
P
K
R
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
S
F
P
R
I
L
A
E
I
E
E
L
A
R
E
L
----
89
PsiBlast_CBE
55.36
31%
-111
- C1 -
4KSP
1
BRAF_HUMAN
A:
[14-254]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
D
-
V
A
V
K
M
L
N
V
T
APT
P
Q
Q
L
Q
A
F
K
-
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
T
K
-----
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
IE
T
--
K
F
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
-------------
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
---------------------
G
S
I
L
W
M
A
P
E
V
I
R
-
M
Q
-
D
K
N
-----
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
----
M
-
T
G
-------
Q
L
P
Y
S
N
I
N
N
R
D
------
Q
I
I
F
M
V
G
R
GY
L
S
P
D
L
S
K
-
V
--
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
P
---
80
PsiBlast_CBE
55.36
31%
-95
- C1 -
3C4C
1
BRAF_HUMAN
A:
[13-267]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
D
-
V
A
V
K
M
L
N
V
T
APT
P
Q
Q
L
Q
A
F
K
-
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
T
K
-----
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
A
--
S
ET
K
F
E
M
K
K
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
A
K
-------------
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
N
T
V
K
I
G
D
F
G
-----------------
S
---
G
S
I
L
W
M
A
P
E
V
I
R
M
Q
D
S
N
P
Y
S
F
Q
-------
S
D
V
Y
A
F
G
I
V
L
Y
E
L
----
M
-
T
G
-------
Q
L
P
Y
S
N
I
N
N
R
D
----
Q
I
I
E
M
V
G
R
G
S
--
L
S
P
D
L
S
K
V
R
S
N
---
C
P
K
R
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
S
F
P
R
I
L
A
E
I
E
E
L
A
R
E
L
S
---
108
PsiBlast_CBE
55.22
31%
-104
- C1 -
4E26
1
B:
[37-277]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
D
-
V
A
V
K
M
L
N
V
T
APTP
Q
Q
L
Q
A
F
K
-
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
T
K
-----
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
IE
T
--
K
F
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
-------------
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
T
V
K
S
-----------
S
---
G
S
I
L
W
M
A
P
E
V
I
--
R
M
Q
D
K
N
-----
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
----
M
-
T
G
-------
Q
L
P
Y
S
N
I
N
N
R
D
------
Q
I
I
F
M
V
G
R
GY
L
S
P
D
L
S
K
---
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
P
---
121
PsiBlast_CBE
54.89
31%
-106
- C1 -
3PRI
1
B:
[37-277]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
D
-
V
A
V
K
M
L
N
V
T
APTP
Q
Q
L
Q
A
F
K
-
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
T
K
-----
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
IE
T
--
K
F
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
-------------
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
T
V
------------
L
S
---
G
S
I
L
W
M
A
P
E
V
I
--
R
M
Q
D
K
N
-----
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
----
M
-
T
G
-------
Q
L
P
Y
S
N
I
N
N
R
D
------
Q
I
I
F
M
V
G
R
GY
L
S
P
D
L
S
K
---
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
P
K
--
84
PsiBlast_CBE
54.62
31%
-104
- C1 -
4JVG
1
BRAF_HUMAN
A:
[17-271]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
D
-
V
A
V
K
M
L
N
V
T
APT
P
Q
Q
L
Q
A
F
K
-
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
T
K
-----
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
A
--
S
ET
K
F
E
M
K
K
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
A
K
-------------
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
N
T
V
K
I
G
D
F
G
L
A
T
V
K
S
----------------
S
I
L
W
M
A
P
E
V
I
R
M
Q
D
S
N
P
Y
S
F
Q
-------
S
D
V
Y
A
F
G
I
V
L
Y
E
L
----
M
-
T
G
-------
Q
L
P
Y
S
N
I
N
N
R
D
----
Q
I
I
E
M
V
G
R
G
S
--
L
S
P
D
L
S
K
V
R
S
N
---
C
P
K
R
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
S
F
P
R
I
L
A
E
I
E
E
L
A
R
E
L
S
---
90
PsiBlast_CBE
54.30
31%
-111
- C1 -
4FC0
1
BRAF_HUMAN
A:
[14-254]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
D
-
V
A
V
K
M
L
N
V
T
APT
P
Q
Q
L
Q
A
F
K
-
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
T
K
-----
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
IE
T
--
K
F
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
-------------
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
---------------------
G
S
I
L
W
M
A
P
E
V
I
R
-
M
----
N
-----
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
----
M
-
T
G
-------
Q
L
P
Y
S
N
I
N
N
R
D
------
Q
I
I
F
M
V
G
R
GY
L
S
P
D
L
S
K
-
V
--
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
P
---
113
PsiBlast_CBE
54.26
31%
-107
- C1 -
3TV4
1
BRAF_HUMAN
A:
[37-277]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
I
T
V
G
Q
R
I
G
--
S
F
G
T
V
Y
K
G
K
W
H
G
D
-
V
A
V
K
M
L
N
V
T
APT
P
Q
Q
L
Q
A
F
K
-
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
T
K
-----
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
IE
T
--
K
F
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
-------------
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
T
V
K
S
R
----------
S
---
G
S
I
L
W
M
A
P
E
V
I
--
R
M
Q
D
K
N
-----
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
----
M
-
T
G
-------
Q
L
P
Y
S
N
I
N
N
R
D
------
Q
I
I
F
M
V
G
R
GY
L
S
P
D
L
S
K
---
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
P
K
--
100
PsiBlast_CBE
53.92
31%
-104
- C1 -
4PP7
1
BRAF_HUMAN
A:
[37-277]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
D
-
V
A
V
K
M
L
N
V
T
APTP
Q
Q
L
Q
A
F
K
-
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
T
K
-----
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
IE
T
--
K
F
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
-------------
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
T
V
K
S
R
W
S
-------
L
S
---
G
S
I
L
W
M
A
P
E
V
I
--
R
M
Q
D
K
N
-----
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
----
M
-
T
G
-------
Q
L
P
Y
S
N
I
N
N
R
D
------
Q
I
I
F
M
V
G
R
GY
L
S
P
D
L
S
K
---
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
----
122
PsiBlast_CBE
53.70
31%
-106
- C1 -
3PRI
1
BRAF_HUMAN
A:
[37-277]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
D
-
V
A
V
K
M
L
N
V
T
APTP
Q
Q
L
Q
A
F
K
-
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
T
K
-----
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
IE
T
--
K
F
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
-------------
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
T
V
------------
L
S
---
G
S
I
L
W
M
A
P
E
V
I
--
R
M
Q
D
K
N
-----
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
----
M
-
T
G
-------
Q
L
P
Y
S
N
I
N
N
R
D
------
Q
I
I
F
M
V
G
R
GY
L
S
P
D
L
S
K
---
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
P
K
--
110
PsiBlast_CBE
53.44
31%
-100
- C1 -
3TV6
1
B:
[37-277]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
D
-
V
A
V
K
M
L
N
V
T
APT
P
Q
Q
L
Q
A
F
K
-
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
T
K
-----
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
IE
T
--
K
F
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
-------------
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
T
V
K
S
R
W
S
G
S
H
Q
F
E
Q
L
S
---
G
S
I
L
W
M
A
P
E
V
I
--
R
M
Q
D
K
N
-----
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
----
M
-
T
G
-------
Q
L
P
Y
S
N
I
N
N
R
D
------
Q
I
I
F
M
V
G
R
GY
L
S
P
D
L
S
K
---
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
P
K
--
95
PsiBlast_CBE
53.29
31%
-105
- C1 -
3II5
1
B:
[36-276]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
D
-
V
A
V
K
M
L
N
V
T
APT
P
Q
Q
L
Q
A
F
K
-
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
T
K
-----
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
IE
T
--
K
F
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
-------------
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
-------------------
G
S
I
L
W
M
A
P
E
V
I
--
R
M
Q
D
K
N
-----
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
----
M
-
T
G
-------
Q
L
P
Y
S
N
I
N
N
R
D
------
Q
I
I
F
M
V
G
R
GY
L
S
P
D
L
S
K
---
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
----
104
PsiBlast_CBE
53.27
31%
-101
- C1 -
4EHE
1
B:
[37-277]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
D
-
V
A
V
K
M
L
N
V
T
APTP
Q
Q
L
Q
A
F
K
-
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
T
K
-----
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
IE
T
--
K
F
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
-------------
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
T
V
K
S
R
W
S
G
S
H
Q
F
E
Q
L
S
---
G
S
I
L
W
M
A
P
E
V
I
--
R
M
Q
D
K
N
-----
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
----
M
-
T
G
-------
Q
L
P
Y
S
N
I
N
N
R
D
------
Q
I
I
F
M
V
G
R
GY
L
S
P
D
L
S
K
---
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
P
K
--
103
PsiBlast_CBE
52.61
31%
-101
- C1 -
4G9C
1
BRAF_HUMAN
A:
[37-277]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
D
-
V
A
V
K
M
L
N
V
T
APT
P
Q
Q
L
Q
A
F
K
-
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
T
K
-----
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
IE
T
--
K
F
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
-------------
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
T
V
K
-----------
L
S
---
G
S
I
L
W
M
A
P
E
V
I
--
R
M
Q
D
K
N
-----
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
----
M
-
T
G
-------
Q
L
P
Y
S
N
I
N
N
R
D
------
Q
I
I
F
M
V
G
R
GY
L
S
P
D
L
S
K
---
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
P
K
--
114
PsiBlast_CBE
52.52
31%
-98
- C1 -
3SKC
1
B:
[37-277]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
D
-
V
A
V
K
M
L
N
V
T
APT
P
Q
Q
L
Q
A
F
K
-
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
T
K
-----
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
IE
T
--
K
F
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
-------------
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
T
V
K
S
R
W
S
G
S
H
Q
F
E
Q
L
S
---
G
S
I
L
W
M
A
P
E
V
I
--
R
M
Q
D
K
N
-----
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
----
M
-
T
G
-------
Q
L
P
Y
S
N
I
N
N
R
D
------
Q
I
I
F
M
V
G
R
GY
L
S
P
D
L
S
K
---
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
P
K
--
99
PsiBlast_CBE
52.36
31%
-101
- C1 -
4PP7
1
B:
[37-277]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
D
-
V
A
V
K
M
L
N
V
T
APTP
Q
Q
L
Q
A
F
K
-
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
T
K
-----
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
IE
T
--
K
F
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
-------------
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
T
V
K
S
R
W
S
G
S
H
Q
F
E
Q
L
S
---
G
S
I
L
W
M
A
P
E
V
I
--
R
M
Q
D
K
N
-----
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
----
M
-
T
G
-------
Q
L
P
Y
S
N
I
N
N
R
D
------
Q
I
I
F
M
V
G
R
GY
L
S
P
D
L
S
K
---
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
----
102
PsiBlast_CBE
52.11
31%
-105
- C1 -
4G9C
1
B:
[37-277]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
D
-
V
A
V
K
M
L
N
V
T
APT
P
Q
Q
L
Q
A
F
K
-
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
T
K
-----
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
IE
T
--
K
F
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
-------------
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
T
V
------------
L
S
---
G
S
I
L
W
M
A
P
E
V
I
--
R
M
Q
D
K
N
-----
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
----
M
-
T
G
-------
Q
L
P
Y
S
N
I
N
N
R
D
------
Q
I
I
F
M
V
G
R
GY
L
S
P
D
L
S
K
---
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
P
K
--
106
PsiBlast_CBE
51.85
31%
-97
- C1 -
4E4X
1
B:
[37-277]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
D
-
V
A
V
K
M
L
N
V
T
APT
P
Q
Q
L
Q
A
F
K
-
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
T
K
-----
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
IE
T
--
K
F
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
-------------
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
T
V
K
S
R
W
S
G
S
H
Q
F
E
Q
L
S
---
G
S
I
L
W
M
A
P
E
V
I
--
R
M
Q
D
K
N
-----
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
----
M
-
T
G
-------
Q
L
P
Y
S
N
I
N
N
R
D
------
Q
I
I
F
M
V
G
R
GY
L
S
P
D
L
S
K
---
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
----
112
PsiBlast_CBE
51.34
31%
-101
- C1 -
3TV4
1
B:
[37-277]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
D
-
V
A
V
K
M
L
N
V
T
APT
P
Q
Q
L
Q
A
F
K
-
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
T
K
-----
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
IE
T
--
K
F
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
-------------
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
T
V
K
S
R
W
S
G
S
H
Q
F
E
Q
L
S
---
G
S
I
L
W
M
A
P
E
V
I
--
R
M
Q
D
K
N
-----
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
----
M
-
T
G
-------
Q
L
P
Y
S
N
I
N
N
R
D
------
Q
I
I
F
M
V
G
R
GY
L
S
P
D
L
S
K
---
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
P
K
--
96
PsiBlast_CBE
51.02
31%
-101
- C1 -
3II5
1
BRAF_HUMAN
A:
[36-276]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
D
-
V
A
V
K
M
L
N
V
T
APT
P
Q
Q
L
Q
A
F
K
-
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
T
K
-----
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
IE
T
--
K
F
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
-------------
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
T
V
-----------
Q
L
S
---
G
S
I
L
W
M
A
P
E
V
I
--
R
M
Q
D
K
N
-----
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
----
M
-
T
G
-------
Q
L
P
Y
S
N
I
N
N
R
D
------
Q
I
I
F
M
V
G
R
GY
L
S
P
D
L
S
K
---
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
-----