@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : BRAF_HUMAN: (2015-10-04 )
MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH
Atome Classification :
(79 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470......---.--480.......490.......500.......510.......520-..-.....530.......540.--...-.-.-.550.......560.......570-........580.......590.......600.......610.---...---...620.....----..630.......640.......650........660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MAALSGGGGGGAEP
G
Q
A
LFNGDMEPEAGAGAGAAASSAADPAI
P
E
E
V
W
N
I
K
Q
M
I
K
L
T
Q
E
H
I
E
A
L
L
D
K
FGGEHNP
P
S
I
Y
L
E
A
Y
E
E
Y
T
S
K
L
D
A
L
Q
Q
R
E
Q
Q
L
L
E
SLGNGT
D
F
SVSSSAS
M
D
T
VTSSSSSS
L
S
VLP
S
S
L
S
VFQNP
T
D
V
ARSNPKSPQK
P
I
V
R
V
FLPNKQ
R
T
V
VPARCG
V
T
V
R
D
S
L
K
K
A
L
M
MRGL
I
P
E
C
C
A
V
Y
RIQDGEKKPIGWDTDISWLTG
E
E
L
H
V
E
V
L
ENVPL
T
T
H
N
F
V
R
K
T
F
F
T
L
A
F
C
D
F
C
R
K
L
L
FQGFRCQTCG
Y
K
F
H
Q
RCSTEV
P
L
M
C
V
N
Y
D
Q
L
D
L
L
F
V
S
K
F
F
E
HHPI
P
Q
E
E
A
S
L
A
E
T
A
LTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPA
D
E
D
H
R
N
Q
FGQRDRSSSAP
N
V
H
I
N
T
IEPV
N
I
D
D
L
I
R
DQGFRGDGGSTTGLSATPPASLPGSL
T
N
V
K
A
L
QKSPGP
Q
R
ERKSSSSS
E
D
R
N
R
M
K
T
LGRRDSSDDWEIPDG
Q
I
T
V
G
Q
R
IGSGSFG
T
V
YK
G
K
WHG---
D
--
V
A
V
K
M
L
NVTAP
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
RKT
R
H
V
N
I
L
L
F
MGYSTK-P
Q
-
L
A
I
V
T
QWCEGSS
L
Y
H
H
L
H
I
--
I
E
T
-
K
-
F
-
E
M
I
K
L
I
D
I
A
R
Q
T
AQG
M
D
Y
L
H
A
K
S
--
I
I
H
R
DLKSN
N
I
F
L
HED
L
T
V
K
IGDF
G
L
A
T
V
K
S
RWSGSH
Q
F
E
Q
L---SG
S
---
I
L
W
MA
P
E
V
IRM----QDKNPYSF
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
MT-GQLPYSNINNR
D
Q
I
I
F
M
VGRGYLSP
D
L
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
KKRDERP
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
P
K
I
H
RSASEPSLNRAGFQTE
D
F
S
L
Y
ACASPKTPIQAGGYGAFPVH
50
PsiBlast_CBE
93.92
100%
-121
- C2 -
5CT7
1
?
A:
[7-279]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
---
D
--
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
T
K
-
P
Q
-
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
--
I
E
T
-
K
-
F
-
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
-------------------
G
S
---
I
L
W
M
A
P
E
V
I
R
M
----
Q
D
K
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
---------------------------------------------
49
PsiBlast_CBE
93.27
100%
-120
- C2 -
5CT7
1
?
B:
[7-279]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
---
D
--
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
T
K
-
P
Q
-
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
--
I
E
T
-
K
-
F
-
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
----------------------
G
S
---
I
L
W
M
A
P
E
V
I
R
M
----
Q
D
K
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
---------------------------------------------
5
PsiBlast_PDB
93.21
100%
-117
- C2 -
3PSB
1
BRAF_HUMAN
A:
[29-304]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
---
D
--
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
T
K
-
P
Q
-
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
--
I
E
T
-
K
-
F
-
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
T
V
-----------------
G
S
---
I
L
W
M
A
P
E
V
I
R
M
----
Q
D
K
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
P
K
-------------------------------------------
17
PsiBlast_PDB
92.85
100%
-118
- C2 -
4G9C
1
BRAF_HUMAN
A:
[29-304]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
---
D
--
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
T
K
-
P
Q
-
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
--
I
E
T
-
K
-
F
-
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
T
V
K
-----------
L
---
S
G
S
---
I
L
W
M
A
P
E
V
I
R
M
----
Q
D
K
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
P
K
-------------------------------------------
51
PsiBlast_CBE
92.84
100%
-122
- C2 -
4H58
1
BRAF_HUMAN
A:
[1-275]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
---
D
--
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
T
K
-
P
Q
-
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
--
I
E
T
-
K
-
F
-
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
T
V
K
S
---------------
G
S
---
I
L
W
M
A
P
E
V
I
R
M
----
Q
D
K
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
P
--------------------------------------------
21
PsiBlast_CBE
92.76
99%
-118
- C2 -
4MNF
1
B:
[42-313]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
---
D
--
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
T
K
-
P
Q
-
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
--
I
E
T
-
K
-
F
-
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
T
E
------------------
S
---
I
L
W
M
A
P
E
V
I
R
M
----
Q
D
K
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
----------------------------------------------
48
PsiBlast_CBE
92.66
100%
-118
- C2 -
4KSP
1
BRAF_HUMAN
A:
[6-280]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
---
D
--
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
T
K
-
P
Q
-
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
--
I
E
T
-
K
-
F
-
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
---------------------
G
S
---
I
L
W
M
A
P
E
V
I
R
M
----
Q
D
K
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
P
--------------------------------------------
40
PsiBlast_CBE
92.49
99%
-117
- C2 -
5C9C
1
?
A:
[30-301]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
---
D
--
V
A
V
K
M
L
N
--
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
T
K
-
P
Q
-
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
--
I
E
T
-
K
-
F
-
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
T
-------------------
S
---
I
L
W
M
A
P
E
V
I
R
M
----
Q
D
K
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
----------------------------------------------
26
PsiBlast_CBE
92.31
100%
-120
- C2 -
4G9C
1
B:
[29-304]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
---
D
--
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
T
K
-
P
Q
-
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
--
I
E
T
-
K
-
F
-
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
T
V
------------
L
---
S
G
S
---
I
L
W
M
A
P
E
V
I
R
M
----
Q
D
K
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
P
K
-------------------------------------------
15
PsiBlast_PDB
92.27
100%
-116
- C2 -
4E26
1
BRAF_HUMAN
A:
[29-304]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
---
D
--
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
T
K
-
P
Q
-
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
--
I
E
T
-
K
-
F
-
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
T
V
K
S
R
------
F
E
Q
L
---
S
G
S
---
I
L
W
M
A
P
E
V
I
R
M
----
Q
D
K
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
P
K
-------------------------------------------
27
PsiBlast_CBE
92.22
100%
-115
- C2 -
4EHE
1
B:
[29-304]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
---
D
--
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
T
K
-
P
Q
-
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
--
I
E
T
-
K
-
F
-
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
T
V
K
S
R
W
S
G
S
H
Q
F
E
Q
L
---
S
G
S
---
I
L
W
M
A
P
E
V
I
R
M
----
Q
D
K
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
P
K
-------------------------------------------
29
PsiBlast_CBE
92.18
100%
-118
- C2 -
4E26
1
B:
[29-303]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
---
D
--
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
T
K
-
P
Q
-
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
--
I
E
T
-
K
-
F
-
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
T
V
K
S
--------------
S
G
S
---
I
L
W
M
A
P
E
V
I
R
M
----
Q
D
K
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
P
--------------------------------------------
38
PsiBlast_CBE
92.10
100%
-115
- C2 -
3PPJ
1
B:
[29-304]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
---
D
--
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
T
K
-
P
Q
-
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
--
I
E
T
-
K
-
F
-
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
T
V
------------
L
---
S
G
S
---
I
L
W
M
A
P
E
V
I
R
M
----
Q
D
K
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
P
K
-------------------------------------------
7
PsiBlast_PDB
92.03
100%
-121
- C2 -
3PPK
1
BRAF_HUMAN
A:
[29-304]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
---
D
--
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
T
K
-
P
Q
-
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
--
I
E
T
-
K
-
F
-
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
T
V
-----------------
G
S
---
I
L
W
M
A
P
E
V
I
R
M
----
Q
D
K
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
P
K
-------------------------------------------
11
PsiBlast_PDB
92.01
100%
-117
- C2 -
3PSD
1
BRAF_HUMAN
A:
[29-304]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
---
D
--
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
T
K
-
P
Q
-
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
--
I
E
T
-
K
-
F
-
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
T
V
-----------------
G
S
---
I
L
W
M
A
P
E
V
I
R
M
----
Q
D
K
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
P
K
-------------------------------------------
44
PsiBlast_CBE
91.85
99%
-117
- C2 -
3IDP
1
B:
[22-293]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
---
D
--
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
T
K
-
P
Q
-
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
--
I
E
T
-
K
-
F
-
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
----------------
L
---
S
G
S
---
I
L
W
M
A
P
E
V
I
R
M
----
Q
D
K
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
----------------------------------------------
16
PsiBlast_PDB
91.84
100%
-123
- C2 -
4E4X
1
BRAF_HUMAN
A:
[29-302]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
---
D
--
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
T
K
-
P
Q
-
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
--
I
E
T
-
K
-
F
-
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
T
V
K
S
R
W
S
-------
L
---
S
G
S
---
I
L
W
M
A
P
E
V
I
R
M
----
Q
D
K
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
---------------------------------------------
8
PsiBlast_PDB
91.68
100%
-122
- C2 -
3PRF
1
BRAF_HUMAN
A:
[29-304]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
---
D
--
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
T
K
-
P
Q
-
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
--
I
E
T
-
K
-
F
-
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
T
V
-----------------
G
S
---
I
L
W
M
A
P
E
V
I
R
M
----
Q
D
K
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
P
K
-------------------------------------------
36
PsiBlast_CBE
91.63
100%
-119
- C2 -
3PRF
1
B:
[29-304]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
---
D
--
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
T
K
-
P
Q
-
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
--
I
E
T
-
K
-
F
-
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
T
V
-----------------
G
S
---
I
L
W
M
A
P
E
V
I
R
M
----
Q
D
K
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
P
K
-------------------------------------------
6
PsiBlast_PDB
91.62
100%
-115
- C2 -
3PPJ
1
BRAF_HUMAN
A:
[29-304]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
---
D
--
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
T
K
-
P
Q
-
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
--
I
E
T
-
K
-
F
-
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
T
V
-----------------
G
S
---
I
L
W
M
A
P
E
V
I
R
M
----
Q
D
K
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
P
K
-------------------------------------------
24
PsiBlast_CBE
91.61
100%
-119
- C2 -
3II5
1
B:
[29-301]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
---
D
--
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
T
K
-
P
Q
-
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
--
I
E
T
-
K
-
F
-
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
-------------------
G
S
---
I
L
W
M
A
P
E
V
I
R
M
----
Q
D
K
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
---------------------------------------------
13
PsiBlast_PDB
91.54
100%
-119
- C2 -
3TV4
1
BRAF_HUMAN
A:
[29-304]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
--
S
F
G
T
V
Y
K
G
K
W
H
G
---
D
--
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
T
K
-
P
Q
-
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
--
I
E
T
-
K
-
F
-
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
T
V
K
S
R
-------------
S
G
S
---
I
L
W
M
A
P
E
V
I
R
M
----
Q
D
K
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
P
K
-------------------------------------------
1
PsiBlast_PDB
91.47
99%
-115
- C2 -
4MNF
1
BRAF_HUMAN
A:
[42-313]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
---
D
--
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
T
K
-
P
Q
-
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
--
I
E
T
-
K
-
F
-
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
T
E
------------------
S
---
I
L
W
M
A
P
E
V
I
R
M
----
Q
D
K
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
----------------------------------------------
33
PsiBlast_CBE
91.29
100%
-116
- C2 -
3PSD
1
B:
[29-304]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
---
D
--
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
T
K
-
P
Q
-
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
--
I
E
T
-
K
-
F
-
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
T
V
------------
L
---
S
G
S
---
I
L
W
M
A
P
E
V
I
R
M
----
Q
D
K
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
P
K
-------------------------------------------
47
PsiBlast_CBE
91.24
100%
-122
- C2 -
4MBJ
1
BRAF_HUMAN
A:
[29-304]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
---
D
--
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
T
K
-
P
Q
-
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
--
I
E
T
-
K
-
F
-
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
T
V
K
S
R
W
S
-------
L
---
S
G
S
---
I
L
W
M
A
P
E
V
I
R
M
----
Q
D
K
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
P
K
-------------------------------------------
31
PsiBlast_CBE
91.19
100%
-117
- C2 -
3TV4
1
B:
[29-304]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
---
D
--
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
T
K
-
P
Q
-
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
--
I
E
T
-
K
-
F
-
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
T
V
K
S
R
W
S
G
S
H
Q
F
E
Q
L
---
S
G
S
---
I
L
W
M
A
P
E
V
I
R
M
----
Q
D
K
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
P
K
-------------------------------------------
10
PsiBlast_PDB
90.99
100%
-119
- C2 -
3Q4C
1
BRAF_HUMAN
A:
[29-304]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
---
D
--
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
T
K
-
P
Q
-
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
--
I
E
T
-
K
-
F
-
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
T
V
K
S
---------------
G
S
---
I
L
W
M
A
P
E
V
I
R
M
----
Q
D
K
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
P
K
-------------------------------------------
43
PsiBlast_CBE
90.87
99%
-119
- C2 -
4EHG
1
BRAF_HUMAN
A:
[29-304]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
---
D
--
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
T
K
-
P
Q
-
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
--
I
E
T
-
K
-
F
-
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
T
E
-----------------
G
S
---
I
L
W
M
A
P
E
V
I
R
M
----
Q
D
K
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
P
K
-------------------------------------------
19
PsiBlast_PDB
90.56
100%
-117
- C2 -
4PP7
1
BRAF_HUMAN
A:
[29-302]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
---
D
--
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
T
K
-
P
Q
-
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
--
I
E
T
-
K
-
F
-
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
T
V
K
S
R
W
S
-------
L
---
S
G
S
---
I
L
W
M
A
P
E
V
I
R
M
----
Q
D
K
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
---------------------------------------------
30
PsiBlast_CBE
90.53
100%
-116
- C2 -
3TV6
1
B:
[29-304]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
---
D
--
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
T
K
-
P
Q
-
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
--
I
E
T
-
K
-
F
-
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
T
V
K
S
R
W
S
G
S
H
Q
F
E
Q
L
---
S
G
S
---
I
L
W
M
A
P
E
V
I
R
M
----
Q
D
K
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
P
K
-------------------------------------------
39
PsiBlast_CBE
90.50
100%
-117
- C2 -
3D4Q
1
B:
[29-304]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
---
D
--
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
T
K
-
P
Q
-
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
--
I
E
T
-
K
-
F
-
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
T
V
------------
L
---
S
G
S
---
I
L
W
M
A
P
E
V
I
R
M
----
Q
D
K
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
P
K
-------------------------------------------
45
PsiBlast_CBE
90.44
99%
-117
- C2 -
3IDP
1
BRAF_HUMAN
A:
[22-293]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
---
D
--
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
T
K
-
P
Q
-
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
--
I
E
T
-
K
-
F
-
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
T
------------------
G
S
---
I
L
W
M
A
P
E
V
I
R
M
----
Q
--
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
----------------------------------------------
37
PsiBlast_CBE
90.26
100%
-117
- C2 -
3PPK
1
B:
[29-304]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
---
D
--
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
T
K
-
P
Q
-
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
--
I
E
T
-
K
-
F
-
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
T
V
------------
L
---
S
G
S
---
I
L
W
M
A
P
E
V
I
R
M
----
Q
D
K
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
P
K
-------------------------------------------
52
PsiBlast_CBE
89.98
99%
-118
- C2 -
1UWH
1
B:
[1-276]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
---
D
--
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
T
A
-
P
Q
-
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
--
I
E
T
-
K
-
F
-
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
T
V
------------
L
---
S
G
S
---
I
L
W
M
A
P
E
V
I
R
M
----
Q
D
K
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
P
K
-------------------------------------------
34
PsiBlast_CBE
89.93
100%
-117
- C2 -
3PSB
1
B:
[29-304]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
---
D
--
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
T
K
-
P
Q
-
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
--
I
E
T
-
K
-
F
-
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
T
V
------------
L
---
S
G
S
---
I
L
W
M
A
P
E
V
I
R
M
----
Q
D
K
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
P
K
-------------------------------------------
12
PsiBlast_PDB
89.89
100%
-121
- C2 -
3SKC
1
BRAF_HUMAN
A:
[29-304]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
---
D
--
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
T
K
-
P
Q
-
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
--
I
E
T
-
K
-
F
-
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
----------------
L
---
S
G
S
---
I
L
W
M
A
P
E
V
I
R
M
----
Q
D
K
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
P
K
-------------------------------------------
14
PsiBlast_PDB
89.85
100%
-118
- C2 -
3TV6
1
BRAF_HUMAN
A:
[29-304]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
---
D
--
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
T
K
-
P
Q
-
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
--
I
E
T
-
K
-
F
-
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
T
V
K
S
R
W
S
-----------
S
G
S
---
I
L
W
M
A
P
E
V
I
R
M
----
Q
D
K
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
P
K
-------------------------------------------
53
PsiBlast_CBE
89.71
99%
-117
- C2 -
1UWH
1
BRAF_HUMAN
A:
[1-276]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
---
D
--
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
T
A
-
P
Q
-
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
--
I
E
T
-
K
-
F
-
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
T
V
------------
L
---
S
G
S
---
I
L
W
M
A
P
E
V
I
R
M
----
Q
D
K
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
P
K
-------------------------------------------
42
PsiBlast_CBE
89.67
99%
-120
- C2 -
4EHG
1
B:
[29-304]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
---
D
--
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
T
K
-
P
Q
-
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
--
I
E
T
-
K
-
F
-
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
----------------
L
---
S
G
S
---
I
L
W
M
A
P
E
V
I
R
M
----
Q
D
K
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
P
K
-------------------------------------------
32
PsiBlast_CBE
89.39
100%
-113
- C2 -
3SKC
1
B:
[29-304]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
---
D
--
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
T
K
-
P
Q
-
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
--
I
E
T
-
K
-
F
-
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
T
V
K
S
R
W
S
G
S
H
Q
F
E
Q
L
---
S
G
S
---
I
L
W
M
A
P
E
V
I
R
M
----
Q
D
K
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
P
K
-------------------------------------------
28
PsiBlast_CBE
89.19
100%
-115
- C2 -
4E4X
1
B:
[29-302]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
---
D
--
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
T
K
-
P
Q
-
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
--
I
E
T
-
K
-
F
-
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
T
V
K
S
R
W
S
G
S
H
Q
F
E
Q
L
---
S
G
S
---
I
L
W
M
A
P
E
V
I
R
M
----
Q
D
K
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
---------------------------------------------
4
PsiBlast_PDB
89.17
100%
-115
- C2 -
3D4Q
1
BRAF_HUMAN
A:
[29-304]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
---
D
--
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
T
K
-
P
Q
-
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
--
I
E
T
-
K
-
F
-
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
T
V
------------
L
---
S
G
S
---
I
L
W
M
A
P
E
V
I
R
M
----
Q
D
K
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
P
K
-------------------------------------------
46
PsiBlast_CBE
89.02
100%
-117
- C2 -
4MBJ
1
B:
[29-304]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
---
D
--
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
T
K
-
P
Q
-
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
--
I
E
T
-
K
-
F
-
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
T
V
K
S
R
W
S
G
S
H
Q
F
E
Q
L
---
S
G
S
---
I
L
W
M
A
P
E
V
I
R
M
----
Q
D
K
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
P
K
-------------------------------------------
25
PsiBlast_CBE
88.71
100%
-114
- C2 -
4PP7
1
B:
[29-302]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
---
D
--
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
T
K
-
P
Q
-
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
--
I
E
T
-
K
-
F
-
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
T
V
K
S
R
W
S
G
S
H
Q
F
E
Q
L
---
S
G
S
---
I
L
W
M
A
P
E
V
I
R
M
----
Q
D
K
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
---------------------------------------------
18
PsiBlast_PDB
88.58
100%
-117
- C2 -
4EHE
1
BRAF_HUMAN
A:
[29-304]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
---
D
--
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
T
K
-
P
Q
-
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
--
I
E
T
-
K
-
F
-
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
T
V
K
S
R
-------------
S
G
S
---
I
L
W
M
A
P
E
V
I
R
M
----
Q
D
K
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
P
K
-------------------------------------------
63
PsiBlast_CBE
88.57
93%
-118
- C2 -
3OG7
1
BRAF_HUMAN
A:
[18-288]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
---
D
--
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
T
A
-
P
Q
-
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
A
--
S
-----
F
-
E
M
K
K
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
N
T
V
K
I
G
D
F
G
---------------------
G
S
---
I
L
W
M
A
P
E
V
I
R
--------
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
E
M
V
G
R
G
S
L
S
P
D
L
S
K
V
R
S
N
C
P
K
R
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
S
F
P
R
I
L
A
E
I
E
E
L
A
R
E
----------------------------------------------
64
PsiBlast_CBE
88.48
94%
-116
- C2 -
4CQE
1
?
B:
[3-275]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
---
T
V
Y
K
G
K
W
H
G
---
D
--
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
T
K
-
P
Q
-
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
A
--
S
E
T
-
K
-
F
-
E
M
K
K
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
N
T
V
K
I
G
D
F
G
---------------------
G
S
---
I
L
W
M
A
P
E
V
I
R
--------
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
E
M
V
G
R
G
S
L
S
P
D
L
S
K
V
R
S
N
C
P
K
R
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
S
F
P
R
I
L
A
E
I
E
E
L
A
R
E
----------------------------------------------
3
PsiBlast_PDB
88.23
100%
-114
- C2 -
3II5
1
BRAF_HUMAN
A:
[28-300]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
---
D
--
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
T
K
-
P
Q
-
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
--
I
E
T
-
K
-
F
-
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
T
V
-----------
Q
L
---
S
G
S
---
I
L
W
M
A
P
E
V
I
R
M
----
Q
D
K
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
----------------------------------------------
62
PsiBlast_CBE
87.83
94%
-115
- C2 -
4WO5
1
B:
[27-298]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
---
D
--
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
T
K
-
P
Q
-
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
A
--
S
E
T
-
K
-
F
-
E
M
K
K
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
N
T
V
K
I
G
D
F
G
L
A
T
------------------
G
S
---
I
L
W
M
A
P
E
V
I
R
M
----
Q
D
S
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
E
M
V
G
R
G
S
L
S
P
D
L
S
K
V
R
S
N
C
P
K
R
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
S
F
P
R
I
L
A
E
I
E
E
L
A
R
E
L
---------------------------------------------
41
PsiBlast_CBE
87.70
99%
-111
- C2 -
4G9R
1
B:
[29-302]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
---
D
--
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
T
K
-
P
Q
-
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
--
I
E
T
-
K
-
F
-
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
T
E
K
----------------
G
S
---
I
L
W
M
A
P
E
V
I
R
M
----
Q
D
K
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
---------------------------------------------
58
PsiBlast_CBE
87.64
94%
-118
- C2 -
4JVG
1
BRAF_HUMAN
B:
[9-282]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
---
D
--
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
T
K
-
P
Q
-
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
A
--
S
E
T
-
K
-
F
-
E
M
K
K
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
N
T
V
K
I
G
D
F
G
L
A
T
-------------------
S
---
I
L
W
M
A
P
E
V
I
R
M
----
Q
D
S
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
E
M
V
G
R
G
S
L
S
P
D
L
S
K
V
R
S
N
C
P
K
R
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
S
F
P
R
I
L
A
E
I
E
E
L
A
R
E
L
S
--------------------------------------------
35
PsiBlast_CBE
87.25
100%
-115
- C2 -
3PRI
1
B:
[29-304]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
---
D
--
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
T
K
-
P
Q
-
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
--
I
E
T
-
K
-
F
-
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
T
V
------------
L
---
S
G
S
---
I
L
W
M
A
P
E
V
I
R
M
----
Q
D
K
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
P
K
-------------------------------------------
9
PsiBlast_PDB
87.25
100%
-115
- C2 -
3PRI
1
BRAF_HUMAN
A:
[29-304]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
---
D
--
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
T
K
-
P
Q
-
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
--
I
E
T
-
K
-
F
-
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
T
V
------------
L
---
S
G
S
---
I
L
W
M
A
P
E
V
I
R
M
----
Q
D
K
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
P
K
-------------------------------------------
20
PsiBlast_PDB
87.21
99%
-111
- C2 -
4G9R
1
BRAF_HUMAN
A:
[29-302]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
---
D
--
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
T
K
-
P
Q
-
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
--
I
E
T
-
K
-
F
-
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
T
E
K
S
---------------
G
S
---
I
L
W
M
A
P
E
V
I
R
M
----
Q
D
K
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
---------------------------------------------
65
PsiBlast_CBE
86.68
94%
-112
- C2 -
4CQE
1
?
A:
[4-275]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
--
G
T
V
Y
K
G
K
W
H
G
---
D
--
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
T
K
-
P
Q
-
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
A
--
S
E
T
-
K
-
F
-
E
M
K
K
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
N
T
V
K
I
G
D
F
G
---------------------
G
S
---
I
L
W
M
A
P
E
V
I
R
M
----
Q
--
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
E
M
V
G
R
G
S
L
S
P
D
L
S
K
V
R
S
N
C
P
K
R
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
S
F
P
R
I
L
A
E
I
E
E
L
A
R
E
----------------------------------------------
54
PsiBlast_CBE
86.53
99%
-108
- C2 -
1UWJ
1
B:
[1-276]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
---
D
--
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
T
K
-
P
Q
-
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
--
I
E
T
-
K
-
F
-
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
T
E
K
----------------
G
S
---
I
L
W
M
A
P
E
V
I
R
M
----
Q
D
K
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
P
K
-------------------------------------------
57
PsiBlast_CBE
85.90
94%
-114
- C2 -
4JVG
1
BRAF_HUMAN
C:
[9-282]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
---
D
--
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
T
K
-
P
Q
-
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
A
--
S
E
T
-
K
-
F
-
E
M
K
K
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
N
T
V
K
I
G
D
F
G
L
A
--------------------
S
---
I
L
W
M
A
P
E
V
I
R
M
----
Q
D
S
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
E
M
V
G
R
G
S
L
S
P
D
L
S
K
V
R
S
N
C
P
K
R
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
S
F
P
R
I
L
A
E
I
E
E
L
A
R
E
L
S
--------------------------------------------
59
PsiBlast_CBE
85.48
94%
-116
- C2 -
4JVG
1
BRAF_HUMAN
A:
[9-282]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
---
D
--
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
T
K
-
P
Q
-
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
A
--
S
E
T
-
K
-
F
-
E
M
K
K
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
N
T
V
K
I
G
D
F
G
L
A
T
V
K
S
----------------
S
---
I
L
W
M
A
P
E
V
I
R
M
----
Q
D
S
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
E
M
V
G
R
G
S
L
S
P
D
L
S
K
V
R
S
N
C
P
K
R
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
S
F
P
R
I
L
A
E
I
E
E
L
A
R
E
L
S
--------------------------------------------
56
PsiBlast_CBE
85.47
94%
-114
- C2 -
4JVG
1
D:
[9-282]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
---
D
--
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
T
K
-
P
Q
-
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
A
--
S
E
T
-
K
-
F
-
E
M
K
K
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
N
T
V
K
I
G
D
F
G
L
A
T
V
K
S
----------------
S
---
I
L
W
M
A
P
E
V
I
R
M
----
Q
D
S
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
E
M
V
G
R
G
S
L
S
P
D
L
S
K
V
R
S
N
C
P
K
R
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
S
F
P
R
I
L
A
E
I
E
E
L
A
R
E
L
S
--------------------------------------------
60
PsiBlast_CBE
84.80
94%
-116
- C2 -
3C4C
1
B:
[5-278]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
---
D
--
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
T
K
-
P
Q
-
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
A
--
S
E
T
-
K
-
F
-
E
M
K
K
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
N
T
V
K
I
G
D
F
---------------------
S
G
S
---
I
L
W
M
A
P
E
V
I
R
M
----
Q
D
S
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
E
M
V
G
R
G
S
L
S
P
D
L
S
K
V
R
S
N
C
P
K
R
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
S
F
P
R
I
L
A
E
I
E
E
L
A
R
E
L
S
--------------------------------------------
61
PsiBlast_CBE
84.71
94%
-106
- C2 -
3C4C
1
BRAF_HUMAN
A:
[5-278]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
---
D
--
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
T
K
-
P
Q
-
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
A
--
S
E
T
-
K
-
F
-
E
M
K
K
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
N
T
V
K
I
G
D
F
G
--------------------
S
G
S
---
I
L
W
M
A
P
E
V
I
R
M
----
Q
D
S
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
E
M
V
G
R
G
S
L
S
P
D
L
S
K
V
R
S
N
C
P
K
R
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
S
F
P
R
I
L
A
E
I
E
E
L
A
R
E
L
S
--------------------------------------------
55
PsiBlast_CBE
84.04
99%
-110
- C2 -
1UWJ
1
BRAF_HUMAN
A:
[1-276]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
---
D
--
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
T
K
-
P
Q
-
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
--
I
E
T
-
K
-
F
-
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
T
E
K
S
---------------
G
S
---
I
L
W
M
A
P
E
V
I
R
M
----
Q
D
K
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
P
K
-------------------------------------------
67
PsiBlast_CBE
83.59
77%
-117
- C2 -
3OMV
1
RAF1_HUMAN
A:
[29-304]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
Y
W
E
I
E
A
S
E
V
M
L
S
T
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
---
D
--
V
A
V
K
I
L
K
V
V
D
P
T
P
E
Q
F
Q
A
F
R
N
E
V
A
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
M
T
K
-
D
N
-
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
K
H
L
H
V
--
Q
E
T
-
K
-
F
-
Q
M
F
Q
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
N
--
I
I
H
R
D
M
K
S
N
N
I
F
L
H
E
G
L
T
V
K
I
G
D
F
G
L
A
T
V
------------
P
---
T
G
S
---
V
L
W
M
A
P
E
V
I
R
M
----
Q
D
N
N
P
F
S
F
Q
S
D
V
Y
S
Y
G
I
V
L
Y
E
L
M
T
-
G
E
L
P
Y
S
H
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
A
S
P
D
L
S
K
L
Y
K
N
C
P
K
A
M
K
R
L
V
A
D
C
V
K
K
V
K
E
E
R
P
L
F
P
Q
I
L
S
S
I
E
L
L
Q
H
S
L
P
K
-------------------------------------------
66
PsiBlast_CBE
82.80
77%
-119
- C2 -
3OMV
1
B:
[29-304]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
Y
W
E
I
E
A
S
E
V
M
L
S
T
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
---
D
--
V
A
V
K
I
L
K
V
V
D
P
T
P
E
Q
F
Q
A
F
R
N
E
V
A
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
M
T
K
-
D
N
-
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
K
H
L
H
V
--
Q
E
T
-
K
-
F
-
Q
M
F
Q
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
N
--
I
I
H
R
D
M
K
S
N
N
I
F
L
H
E
G
L
T
V
K
I
G
D
F
G
L
A
T
V
------------
P
---
T
G
S
---
V
L
W
M
A
P
E
V
I
R
M
----
Q
D
N
N
P
F
S
F
Q
S
D
V
Y
S
Y
G
I
V
L
Y
E
L
M
T
-
G
E
L
P
Y
S
H
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
A
S
P
D
L
S
K
L
Y
K
N
C
P
K
A
M
K
R
L
V
A
D
C
V
K
K
V
K
E
E
R
P
L
F
P
Q
I
L
S
S
I
E
L
L
Q
H
S
L
P
K
-------------------------------------------
69
PsiBlast_CBE
63.24
36%
-109
- C2 -
3P86
1
CTR1_ARATH
A:
[32-298]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
D
I
P
W
C
D
L
N
I
K
E
K
I
G
A
G
S
F
G
T
V
H
R
A
E
W
H
G
S
--
D
--
V
A
V
K
I
L
M
E
Q
D
F
H
A
E
R
V
N
E
F
L
R
E
V
A
I
M
K
R
L
R
H
P
N
I
V
L
F
M
G
A
V
T
Q
P
P
N
-
L
S
I
V
T
E
Y
L
S
R
G
S
L
Y
R
L
L
H
K
SG
A
R
E
-
Q
-
L
-
D
E
R
R
R
L
S
M
A
Y
D
V
A
K
G
M
N
Y
L
H
N
R
N
P
P
I
V
H
R
N
L
K
S
P
N
L
L
V
D
K
K
Y
T
V
K
V
C
D
F
----------------------
G
T
---
P
E
W
M
A
P
E
V
L
R
-------
D
E
P
S
N
E
K
S
D
V
Y
S
F
G
V
I
L
W
E
L
A
T
-
L
Q
Q
P
W
G
N
L
N
P
A
-
Q
V
V
A
A
V
--
G
F
K
C
K
R
L
E
I
P
R
N
L
N
P
Q
-
V
A
A
I
I
E
G
C
W
T
N
E
P
W
K
R
P
S
F
A
T
I
M
D
L
L
R
P
L
I
K
-----------------------------------------------
96
PsiBlast_CBE
61.27
33%
-109
- C2 -
4DGG
1
SRC_CHICK
B:
[9-270]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
K
D
A
W
E
I
P
R
E
S
L
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
G
---
T
T
R
V
A
I
K
T
L
K
P
---------
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
-
E
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
--
E
M
G
-
K
-
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
--
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
----
R
L
---------------FP-
I
K
W
T
A
P
E
A
A
L
Y
-------
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
-
V
L
D
Q
V
E
R
G
Y
R
M
P
----
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
P
G
E
N
L
-----------------------------------
90
PsiBlast_CBE
61.04
33%
-106
- C2 -
4U5J
1
SRC_CHICK
B:
[12-270]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
W
E
I
P
R
E
S
L
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
G
---
T
TR
V
A
I
K
T
L
K
P
G
T
M
S
P
E
---
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
-
E
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
--
E
M
G
-
K
-
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
--
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
----
R
L
I
E
-----------
G
A
KFP
I
K
W
T
A
P
E
A
A
L
Y
-------
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
-
V
L
D
Q
V
E
R
G
Y
R
M
P
----
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
P
G
E
N
L
-----------------------------------
76
PsiBlast_CBE
60.57
33%
-100
- C2 -
2SRC
1
SRC_HUMAN
A:
[175-436]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
K
D
A
W
E
I
P
R
E
S
L
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
G
---
T
T
R
V
A
I
K
T
L
K
P
G
T
M
S
P
E
---
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
-
E
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
--
E
T
G
-
K
-
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
--
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
----
R
L
I
E
D
N
E
Y
T
A
R
---
Q
G
A
KFP
I
K
W
T
A
P
E
A
A
L
Y
-------
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
-
V
L
D
Q
V
E
R
G
Y
R
M
P
----
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
P
G
E
N
L
-----------------------------------
71
PsiBlast_CBE
60.02
36%
-105
- C2 -
4CSV
1
?
A:
[5-267]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
E
I
P
R
S
E
I
T
L
E
R
K
L
G
S
G
Q
F
G
E
V
Y
E
G
K
W
R
N
YN
I
E
--
V
A
V
K
T
L
K
---
E
G
T
M
S
V
E
E
F
L
Q
E
A
Q
I
M
K
K
L
K
H
P
N
L
V
Q
L
Y
G
V
C
T
K
E
P
P
-
I
Y
I
I
T
E
Y
M
S
H
G
S
L
L
D
Y
L
R
D
--
C
-----
V
-
N
A
Q
A
L
L
D
M
A
A
Q
V
A
S
G
M
A
Y
L
E
S
Q
N
--
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
N
V
V
K
V
A
D
F
G
-----------------------FP-
I
K
W
T
A
P
E
A
I
-------
S
Y
N
R
F
S
I
K
S
D
V
W
A
F
G
I
L
L
W
E
I
F
T
Y
G
Q
V
P
Y
P
G
M
S
G
-
S
E
V
I
E
Q
V
E
R
G
Y
R
M
P
R
----
P
Q
G
C
P
E
E
I
Y
E
L
M
L
Q
C
W
N
K
S
P
E
E
R
P
T
F
A
E
T
L
H
A
L
E
T
M
F
L
-----------------------------------------------
99
PsiBlast_CBE
59.75
33%
-106
- C2 -
4AGW
3
SRC_CHICK
A:
[10-270]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
D
A
W
E
I
P
R
E
S
L
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
G
---
T
T
R
V
A
I
K
T
L
K
P
G
T
M
S
P
E
---
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
-
E
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
--
E
M
G
-
K
-
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
--
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
------------------------P--
I
K
W
T
A
P
E
A
A
L
Y
-------
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
-
V
L
D
Q
V
E
R
G
Y
R
M
P
----
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
P
G
E
N
L
-----------------------------------
91
PsiBlast_CBE
59.25
33%
-106
- C2 -
4U5J
1
SRC_CHICK
A:
[12-270]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
W
E
I
P
R
E
S
L
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
G
---
T
T
R
V
A
I
K
T
L
K
P
G
T
M
S
P
E
---
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
-
E
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
--
E
M
G
-
K
-
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
--
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
----
R
L
I
E
-----------
G
A
KFP
I
K
W
T
A
P
E
A
A
L
Y
-------
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
-
V
L
D
Q
V
E
R
G
Y
R
M
P
----
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
P
G
E
N
L
-----------------------------------
87
PsiBlast_CBE
59.04
33%
-111
- C2 -
3QLF
1
SRC_CHICK
A:
[11-270]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
W
E
I
P
R
E
S
L
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
G
---
T
T
R
V
A
I
K
T
L
K
------------
L
Q
E
A
Q
V
M
K
K
I
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
-
E
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
--
E
M
G
-
K
-
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
--
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
------------------------FP-
I
K
W
T
A
P
E
A
A
L
Y
-------
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
-
V
L
D
Q
V
E
R
G
Y
R
M
P
----
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
P
G
E
N
L
-----------------------------------
98
PsiBlast_CBE
57.60
33%
-105
- C2 -
4AGW
3
SRC_CHICK
B:
[11-270]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
W
E
I
P
R
E
S
L
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
G
---
T
TR
V
A
I
K
T
L
K
P
G
T
M
S
P
E
---
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
-
E
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
--
E
M
G
-
K
-
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
--
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
------------------------P--
I
K
W
T
A
P
E
A
A
L
Y
-------
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
-
V
L
D
Q
V
E
R
G
Y
R
M
P
----
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
P
G
E
N
L
-----------------------------------
89
PsiBlast_CBE
56.69
33%
-102
- C2 -
3OEZ
2
SRC_CHICK
A:
[10-270]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
D
A
W
E
I
P
R
E
S
L
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
G
---
T
T
R
V
A
I
K
T
L
K
P
G
T
M
S
P
E
---
A
F
L
Q
E
A
Q
V
M
K
K
I
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
-
E
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
--
E
M
G
-
K
-
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
--
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
----------------------FP-
I
K
W
T
A
P
E
A
A
L
Y
-------
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
-
V
L
D
Q
V
E
R
G
Y
R
M
P
----
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
P
G
E
N
L
-----------------------------------
88
PsiBlast_CBE
56.66
33%
-100
- C2 -
3OEZ
1
SRC_CHICK
B:
[9-270]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
K
D
A
W
E
I
P
R
E
S
L
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
G
---
T
T
R
V
A
I
K
T
L
K
P
G
T
M
S
P
E
---
A
F
L
Q
E
A
Q
V
M
K
K
I
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
-
E
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
--
E
M
G
-
K
-
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
--
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
-----------------------FP-
I
K
W
T
A
P
E
A
A
L
Y
-------
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
-
V
L
D
Q
V
E
R
G
Y
R
M
P
----
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
P
G
E
N
L
-----------------------------------
70
PsiBlast_CBE
56.25
36%
-96
- C2 -
4UEU
1
?
A:
[4-267]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
E
I
P
R
S
E
I
T
L
E
R
K
L
G
S
G
Q
F
G
E
V
Y
E
G
K
W
R
N
YN
I
E
--
V
A
V
K
T
L
K
---
E
G
T
M
S
V
E
E
F
L
Q
E
A
Q
I
M
K
K
L
K
H
P
N
L
V
Q
L
Y
G
V
C
T
K
E
P
P
-
I
Y
I
I
T
E
Y
M
S
H
G
S
L
L
D
Y
L
R
D
--
C
E
G
-
H
T
V
-
N
A
Q
A
L
L
D
M
A
A
Q
V
A
S
G
M
A
Y
L
E
S
Q
N
--
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
N
V
V
K
V
A
D
F
G
L
A
----
R
L
I
-------------
A
KFP
I
K
W
T
A
P
E
A
I
-------
S
Y
N
R
F
S
I
K
S
D
V
W
A
F
G
I
L
L
W
E
I
F
T
Y
G
Q
V
P
Y
P
G
M
S
G
-
S
E
V
I
E
Q
V
E
R
G
Y
R
M
P
R
----
P
Q
G
C
P
E
E
I
Y
E
L
M
L
Q
C
W
N
K
S
P
E
E
R
P
T
F
A
E
T
L
H
A
L
E
T
M
F
------------------------------------------------
73
PsiBlast_CBE
55.56
33%
-105
- C2 -
2BDJ
1
SRC_HUMAN
A:
[3-263]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
D
A
W
E
I
P
R
E
S
L
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
G
---
T
T
R
V
A
I
K
T
L
K
P
G
T
M
S
P
E
---
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
-
E
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
--
E
T
G
-
K
-
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
--
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
----
R
L
I
E
-------------FP-
I
K
W
T
A
P
E
A
A
L
Y
-------
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
-
V
L
D
Q
V
E
R
G
Y
R
M
P
----
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
-----------------------------------------------
68
PsiBlast_CBE
55.24
36%
-92
- C2 -
2Y4I
1
B:
[27-300]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
W
D
I
P
F
E
Q
L
E
I
G
E
L
I
G
K
G
R
F
G
Q
V
Y
H
G
R
W
H
G
---
E
--
V
A
I
R
L
I
D
I
E
R
D
N
E
D
Q
L
K
A
F
K
R
E
V
M
A
Y
R
Q
T
R
H
E
N
V
V
L
F
M
G
A
C
M
S
P
P
H
-
L
A
I
I
T
S
L
C
K
G
R
T
L
Y
S
V
V
R
D
--
A
K
I
-
V
-
L
-
D
V
N
K
T
R
Q
I
A
Q
E
I
V
K
G
M
G
Y
L
H
A
K
G
--
I
L
H
K
D
L
K
S
K
N
V
F
-
Y
D
--
K
V
V
I
T
D
F
G
L
F
S
----------
E
D
K
L
RIQ
N
G
W
---
L
C
H
L
A
P
E
I
I
R
Q
LSPD
E
D
K
L
P
F
S
K
H
S
D
V
F
A
L
G
T
I
W
Y
E
L
H
A
-
R
E
W
P
F
K
T
-
Q
P
A
E
A
I
I
W
Q
M
G
T
G
-
M
K
P
N
L
S
Q
I
--
G
M
G
K
E
I
S
D
I
L
L
F
C
W
A
F
E
Q
E
E
R
P
T
F
T
K
L
M
D
M
L
E
----
K
L
---------------------------------------------
80
PsiBlast_CBE
51.50
35%
-100
- C2 -
3A4O
1
LYN_HUMAN
X:
[6-258]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
W
E
I
P
R
E
S
I
K
L
V
K
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
N
N
---
S
TK
V
A
V
K
T
L
K
---
P
G
T
M
S
V
Q
A
F
L
E
E
A
N
L
M
K
T
L
Q
H
D
K
L
V
R
L
Y
A
V
V
T
R
-
E
E
P
I
Y
I
I
T
E
Y
M
A
K
G
S
L
L
D
F
L
K
S
--
D
E
G
G
K
-
V
-
L
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
Y
I
E
R
K
N
--
Y
I
H
R
D
L
R
A
A
N
V
L
V
S
E
S
L
M
C
K
I
A
D
F
G
L
A
R
V
----------------
E
G
A
KFP
I
K
W
T
A
P
E
A
I
N
F
-------
G
C
F
T
I
K
S
D
V
W
S
F
G
I
L
L
Y
E
I
V
T
Y
G
K
I
P
Y
P
G
R
T
N
A
D
-
V
M
T
A
L
S
Q
G
Y
R
M
P
R
V
----
E
N
C
P
D
E
L
Y
D
I
M
K
M
C
W
K
E
K
A
E
E
R
P
T
F
D
Y
L
Q
S
V
L
D
D
F
Y
T
A
T
E
--------------------------------------------