@TOME V2.3
(Nov 2016)

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Alignment:

3D Common Core:

Structural Clustering:

Modeller Result :

Complexes Modeling
Templates Information:
Sequence & Result Tab:

Values color: [ Good | Correct | Middling | Bad ]Sequence color : MutatedHelixStrandConserved

Query sequence : BRAF_HUMAN: (2015-10-04 )
MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH

Atome Classification :

(79 SA) .........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470......---.--480.......490.......500.......510.......520-..-.....530.......540.--...-.-.-.550.......560.......570-........580.......590.......600.......610.---...---...620.....----..630.......640.......650........660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760....
(Atome) (Ident) (Tito) (Num) (Ligand) (Uniprot) MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHG---D--VAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTK-PQ-LAIVTQWCEGSSLYHHLHI--IET-K-F-EMIKLIDIARQTAQGMDYLHAKS--IIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQL---SGS---ILWMAPEVIRM----QDKNPYSFQSDVYAFGIVLYELMT-GQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH
50 PsiBlast_CBE 93.92100%-121 - C2 -5CT7 ? A:[7-279] ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DWEIPDGQITVGQRIGSGSFGTVYKGKWHG---D--VAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTK-PQ-LAIVTQWCEGSSLYHHLHI--IET-K-F-EMIKLIDIARQTAQGMDYLHAKS--IIHRDLKSNNIFLHEDLTVKIGDFGLA-------------------GS---ILWMAPEVIRM----QDKNPYSFQSDVYAFGIVLYELMT-GQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSL---------------------------------------------
49 PsiBlast_CBE 93.27100%-120 - C2 -5CT7 ? B:[7-279] ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DWEIPDGQITVGQRIGSGSFGTVYKGKWHG---D--VAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTK-PQ-LAIVTQWCEGSSLYHHLHI--IET-K-F-EMIKLIDIARQTAQGMDYLHAKS--IIHRDLKSNNIFLHEDLTVKIGDF----------------------GS---ILWMAPEVIRM----QDKNPYSFQSDVYAFGIVLYELMT-GQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSL---------------------------------------------
5 PsiBlast_PDB 93.21100%-117 - C2 -3PSB BRAF_HUMAN A:[29-304] ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DDWEIPDGQITVGQRIGSGSFGTVYKGKWHG---D--VAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTK-PQ-LAIVTQWCEGSSLYHHLHI--IET-K-F-EMIKLIDIARQTAQGMDYLHAKS--IIHRDLKSNNIFLHEDLTVKIGDFGLATV-----------------GS---ILWMAPEVIRM----QDKNPYSFQSDVYAFGIVLYELMT-GQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPK-------------------------------------------
17 PsiBlast_PDB 92.85100%-118 - C2 -4G9C BRAF_HUMAN A:[29-304] ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DDWEIPDGQITVGQRIGSGSFGTVYKGKWHG---D--VAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTK-PQ-LAIVTQWCEGSSLYHHLHI--IET-K-F-EMIKLIDIARQTAQGMDYLHAKS--IIHRDLKSNNIFLHEDLTVKIGDFGLATVK-----------L---SGS---ILWMAPEVIRM----QDKNPYSFQSDVYAFGIVLYELMT-GQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPK-------------------------------------------
51 PsiBlast_CBE 92.84100%-122 - C2 -4H58 BRAF_HUMAN A:[1-275] ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DDWEIPDGQITVGQRIGSGSFGTVYKGKWHG---D--VAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTK-PQ-LAIVTQWCEGSSLYHHLHI--IET-K-F-EMIKLIDIARQTAQGMDYLHAKS--IIHRDLKSNNIFLHEDLTVKIGDFGLATVKS---------------GS---ILWMAPEVIRM----QDKNPYSFQSDVYAFGIVLYELMT-GQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLP--------------------------------------------
21 PsiBlast_CBE 92.7699%-118 - C2 -4MNF B:[42-313] ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DWEIPDGQITVGQRIGSGSFGTVYKGKWHG---D--VAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTK-PQ-LAIVTQWCEGSSLYHHLHI--IET-K-F-EMIKLIDIARQTAQGMDYLHAKS--IIHRDLKSNNIFLHEDLTVKIGDFGLATE------------------S---ILWMAPEVIRM----QDKNPYSFQSDVYAFGIVLYELMT-GQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARS----------------------------------------------
48 PsiBlast_CBE 92.66100%-118 - C2 -4KSP BRAF_HUMAN A:[6-280] ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DDWEIPDGQITVGQRIGSGSFGTVYKGKWHG---D--VAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTK-PQ-LAIVTQWCEGSSLYHHLHI--IET-K-F-EMIKLIDIARQTAQGMDYLHAKS--IIHRDLKSNNIFLHEDLTVKIGDFG---------------------GS---ILWMAPEVIRM----QDKNPYSFQSDVYAFGIVLYELMT-GQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLP--------------------------------------------
40 PsiBlast_CBE 92.4999%-117 - C2 -5C9C ? A:[30-301] ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DWEIPDGQITVGQRIGSGSFGTVYKGKWHG---D--VAVKMLN--APTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTK-PQ-LAIVTQWCEGSSLYHHLHI--IET-K-F-EMIKLIDIARQTAQGMDYLHAKS--IIHRDLKSNNIFLHEDLTVKIGDFGLAT-------------------S---ILWMAPEVIRM----QDKNPYSFQSDVYAFGIVLYELMT-GQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARS----------------------------------------------
26 PsiBlast_CBE 92.31100%-120 - C2 -4G9C B:[29-304] ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DDWEIPDGQITVGQRIGSGSFGTVYKGKWHG---D--VAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTK-PQ-LAIVTQWCEGSSLYHHLHI--IET-K-F-EMIKLIDIARQTAQGMDYLHAKS--IIHRDLKSNNIFLHEDLTVKIGDFGLATV------------L---SGS---ILWMAPEVIRM----QDKNPYSFQSDVYAFGIVLYELMT-GQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPK-------------------------------------------
15 PsiBlast_PDB 92.27100%-116 - C2 -4E26 BRAF_HUMAN A:[29-304] ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DDWEIPDGQITVGQRIGSGSFGTVYKGKWHG---D--VAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTK-PQ-LAIVTQWCEGSSLYHHLHI--IET-K-F-EMIKLIDIARQTAQGMDYLHAKS--IIHRDLKSNNIFLHEDLTVKIGDFGLATVKSR------FEQL---SGS---ILWMAPEVIRM----QDKNPYSFQSDVYAFGIVLYELMT-GQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPK-------------------------------------------
27 PsiBlast_CBE 92.22100%-115 - C2 -4EHE B:[29-304] ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DDWEIPDGQITVGQRIGSGSFGTVYKGKWHG---D--VAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTK-PQ-LAIVTQWCEGSSLYHHLHI--IET-K-F-EMIKLIDIARQTAQGMDYLHAKS--IIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQL---SGS---ILWMAPEVIRM----QDKNPYSFQSDVYAFGIVLYELMT-GQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPK-------------------------------------------
29 PsiBlast_CBE 92.18100%-118 - C2 -4E26 B:[29-303] ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DDWEIPDGQITVGQRIGSGSFGTVYKGKWHG---D--VAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTK-PQ-LAIVTQWCEGSSLYHHLHI--IET-K-F-EMIKLIDIARQTAQGMDYLHAKS--IIHRDLKSNNIFLHEDLTVKIGDFGLATVKS--------------SGS---ILWMAPEVIRM----QDKNPYSFQSDVYAFGIVLYELMT-GQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLP--------------------------------------------
38 PsiBlast_CBE 92.10100%-115 - C2 -3PPJ B:[29-304] ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DDWEIPDGQITVGQRIGSGSFGTVYKGKWHG---D--VAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTK-PQ-LAIVTQWCEGSSLYHHLHI--IET-K-F-EMIKLIDIARQTAQGMDYLHAKS--IIHRDLKSNNIFLHEDLTVKIGDFGLATV------------L---SGS---ILWMAPEVIRM----QDKNPYSFQSDVYAFGIVLYELMT-GQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPK-------------------------------------------
7 PsiBlast_PDB 92.03100%-121 - C2 -3PPK BRAF_HUMAN A:[29-304] ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DDWEIPDGQITVGQRIGSGSFGTVYKGKWHG---D--VAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTK-PQ-LAIVTQWCEGSSLYHHLHI--IET-K-F-EMIKLIDIARQTAQGMDYLHAKS--IIHRDLKSNNIFLHEDLTVKIGDFGLATV-----------------GS---ILWMAPEVIRM----QDKNPYSFQSDVYAFGIVLYELMT-GQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPK-------------------------------------------
11 PsiBlast_PDB 92.01100%-117 - C2 -3PSD BRAF_HUMAN A:[29-304] ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DDWEIPDGQITVGQRIGSGSFGTVYKGKWHG---D--VAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTK-PQ-LAIVTQWCEGSSLYHHLHI--IET-K-F-EMIKLIDIARQTAQGMDYLHAKS--IIHRDLKSNNIFLHEDLTVKIGDFGLATV-----------------GS---ILWMAPEVIRM----QDKNPYSFQSDVYAFGIVLYELMT-GQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPK-------------------------------------------
44 PsiBlast_CBE 91.8599%-117 - C2 -3IDP B:[22-293] ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DWEIPDGQITVGQRIGSGSFGTVYKGKWHG---D--VAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTK-PQ-LAIVTQWCEGSSLYHHLHI--IET-K-F-EMIKLIDIARQTAQGMDYLHAKS--IIHRDLKSNNIFLHEDLTVKIGDFG----------------L---SGS---ILWMAPEVIRM----QDKNPYSFQSDVYAFGIVLYELMT-GQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARS----------------------------------------------
16 PsiBlast_PDB 91.84100%-123 - C2 -4E4X BRAF_HUMAN A:[29-302] ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DDWEIPDGQITVGQRIGSGSFGTVYKGKWHG---D--VAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTK-PQ-LAIVTQWCEGSSLYHHLHI--IET-K-F-EMIKLIDIARQTAQGMDYLHAKS--IIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWS-------L---SGS---ILWMAPEVIRM----QDKNPYSFQSDVYAFGIVLYELMT-GQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSL---------------------------------------------
8 PsiBlast_PDB 91.68100%-122 - C2 -3PRF BRAF_HUMAN A:[29-304] ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DDWEIPDGQITVGQRIGSGSFGTVYKGKWHG---D--VAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTK-PQ-LAIVTQWCEGSSLYHHLHI--IET-K-F-EMIKLIDIARQTAQGMDYLHAKS--IIHRDLKSNNIFLHEDLTVKIGDFGLATV-----------------GS---ILWMAPEVIRM----QDKNPYSFQSDVYAFGIVLYELMT-GQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPK-------------------------------------------
36 PsiBlast_CBE 91.63100%-119 - C2 -3PRF B:[29-304] ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DDWEIPDGQITVGQRIGSGSFGTVYKGKWHG---D--VAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTK-PQ-LAIVTQWCEGSSLYHHLHI--IET-K-F-EMIKLIDIARQTAQGMDYLHAKS--IIHRDLKSNNIFLHEDLTVKIGDFGLATV-----------------GS---ILWMAPEVIRM----QDKNPYSFQSDVYAFGIVLYELMT-GQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPK-------------------------------------------
6 PsiBlast_PDB 91.62100%-115 - C2 -3PPJ BRAF_HUMAN A:[29-304] ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DDWEIPDGQITVGQRIGSGSFGTVYKGKWHG---D--VAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTK-PQ-LAIVTQWCEGSSLYHHLHI--IET-K-F-EMIKLIDIARQTAQGMDYLHAKS--IIHRDLKSNNIFLHEDLTVKIGDFGLATV-----------------GS---ILWMAPEVIRM----QDKNPYSFQSDVYAFGIVLYELMT-GQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPK-------------------------------------------
24 PsiBlast_CBE 91.61100%-119 - C2 -3II5 B:[29-301] ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DWEIPDGQITVGQRIGSGSFGTVYKGKWHG---D--VAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTK-PQ-LAIVTQWCEGSSLYHHLHI--IET-K-F-EMIKLIDIARQTAQGMDYLHAKS--IIHRDLKSNNIFLHEDLTVKIGDFGLA-------------------GS---ILWMAPEVIRM----QDKNPYSFQSDVYAFGIVLYELMT-GQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSL---------------------------------------------
13 PsiBlast_PDB 91.54100%-119 - C2 -3TV4 BRAF_HUMAN A:[29-304] ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DDWEIPDGQITVGQRIG--SFGTVYKGKWHG---D--VAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTK-PQ-LAIVTQWCEGSSLYHHLHI--IET-K-F-EMIKLIDIARQTAQGMDYLHAKS--IIHRDLKSNNIFLHEDLTVKIGDFGLATVKSR-------------SGS---ILWMAPEVIRM----QDKNPYSFQSDVYAFGIVLYELMT-GQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPK-------------------------------------------
1 PsiBlast_PDB 91.4799%-115 - C2 -4MNF BRAF_HUMAN A:[42-313] ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DWEIPDGQITVGQRIGSGSFGTVYKGKWHG---D--VAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTK-PQ-LAIVTQWCEGSSLYHHLHI--IET-K-F-EMIKLIDIARQTAQGMDYLHAKS--IIHRDLKSNNIFLHEDLTVKIGDFGLATE------------------S---ILWMAPEVIRM----QDKNPYSFQSDVYAFGIVLYELMT-GQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARS----------------------------------------------
33 PsiBlast_CBE 91.29100%-116 - C2 -3PSD B:[29-304] ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DDWEIPDGQITVGQRIGSGSFGTVYKGKWHG---D--VAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTK-PQ-LAIVTQWCEGSSLYHHLHI--IET-K-F-EMIKLIDIARQTAQGMDYLHAKS--IIHRDLKSNNIFLHEDLTVKIGDFGLATV------------L---SGS---ILWMAPEVIRM----QDKNPYSFQSDVYAFGIVLYELMT-GQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPK-------------------------------------------
47 PsiBlast_CBE 91.24100%-122 - C2 -4MBJ BRAF_HUMAN A:[29-304] ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DDWEIPDGQITVGQRIGSGSFGTVYKGKWHG---D--VAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTK-PQ-LAIVTQWCEGSSLYHHLHI--IET-K-F-EMIKLIDIARQTAQGMDYLHAKS--IIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWS-------L---SGS---ILWMAPEVIRM----QDKNPYSFQSDVYAFGIVLYELMT-GQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPK-------------------------------------------
31 PsiBlast_CBE 91.19100%-117 - C2 -3TV4 B:[29-304] ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DDWEIPDGQITVGQRIGSGSFGTVYKGKWHG---D--VAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTK-PQ-LAIVTQWCEGSSLYHHLHI--IET-K-F-EMIKLIDIARQTAQGMDYLHAKS--IIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQL---SGS---ILWMAPEVIRM----QDKNPYSFQSDVYAFGIVLYELMT-GQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPK-------------------------------------------
10 PsiBlast_PDB 90.99100%-119 - C2 -3Q4C BRAF_HUMAN A:[29-304] ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DDWEIPDGQITVGQRIGSGSFGTVYKGKWHG---D--VAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTK-PQ-LAIVTQWCEGSSLYHHLHI--IET-K-F-EMIKLIDIARQTAQGMDYLHAKS--IIHRDLKSNNIFLHEDLTVKIGDFGLATVKS---------------GS---ILWMAPEVIRM----QDKNPYSFQSDVYAFGIVLYELMT-GQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPK-------------------------------------------
43 PsiBlast_CBE 90.8799%-119 - C2 -4EHG BRAF_HUMAN A:[29-304] ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DDWEIPDGQITVGQRIGSGSFGTVYKGKWHG---D--VAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTK-PQ-LAIVTQWCEGSSLYHHLHI--IET-K-F-EMIKLIDIARQTAQGMDYLHAKS--IIHRDLKSNNIFLHEDLTVKIGDFGLATE-----------------GS---ILWMAPEVIRM----QDKNPYSFQSDVYAFGIVLYELMT-GQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPK-------------------------------------------
19 PsiBlast_PDB 90.56100%-117 - C2 -4PP7 BRAF_HUMAN A:[29-302] ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DDWEIPDGQITVGQRIGSGSFGTVYKGKWHG---D--VAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTK-PQ-LAIVTQWCEGSSLYHHLHI--IET-K-F-EMIKLIDIARQTAQGMDYLHAKS--IIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWS-------L---SGS---ILWMAPEVIRM----QDKNPYSFQSDVYAFGIVLYELMT-GQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSL---------------------------------------------
30 PsiBlast_CBE 90.53100%-116 - C2 -3TV6 B:[29-304] ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DDWEIPDGQITVGQRIGSGSFGTVYKGKWHG---D--VAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTK-PQ-LAIVTQWCEGSSLYHHLHI--IET-K-F-EMIKLIDIARQTAQGMDYLHAKS--IIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQL---SGS---ILWMAPEVIRM----QDKNPYSFQSDVYAFGIVLYELMT-GQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPK-------------------------------------------
39 PsiBlast_CBE 90.50100%-117 - C2 -3D4Q B:[29-304] ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DDWEIPDGQITVGQRIGSGSFGTVYKGKWHG---D--VAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTK-PQ-LAIVTQWCEGSSLYHHLHI--IET-K-F-EMIKLIDIARQTAQGMDYLHAKS--IIHRDLKSNNIFLHEDLTVKIGDFGLATV------------L---SGS---ILWMAPEVIRM----QDKNPYSFQSDVYAFGIVLYELMT-GQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPK-------------------------------------------
45 PsiBlast_CBE 90.4499%-117 - C2 -3IDP BRAF_HUMAN A:[22-293] ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DWEIPDGQITVGQRIGSGSFGTVYKGKWHG---D--VAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTK-PQ-LAIVTQWCEGSSLYHHLHI--IET-K-F-EMIKLIDIARQTAQGMDYLHAKS--IIHRDLKSNNIFLHEDLTVKIGDFGLAT------------------GS---ILWMAPEVIRM----Q--NPYSFQSDVYAFGIVLYELMT-GQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARS----------------------------------------------
37 PsiBlast_CBE 90.26100%-117 - C2 -3PPK B:[29-304] ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DDWEIPDGQITVGQRIGSGSFGTVYKGKWHG---D--VAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTK-PQ-LAIVTQWCEGSSLYHHLHI--IET-K-F-EMIKLIDIARQTAQGMDYLHAKS--IIHRDLKSNNIFLHEDLTVKIGDFGLATV------------L---SGS---ILWMAPEVIRM----QDKNPYSFQSDVYAFGIVLYELMT-GQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPK-------------------------------------------
52 PsiBlast_CBE 89.9899%-118 - C2 -1UWH B:[1-276] ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DDWEIPDGQITVGQRIGSGSFGTVYKGKWHG---D--VAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTA-PQ-LAIVTQWCEGSSLYHHLHI--IET-K-F-EMIKLIDIARQTAQGMDYLHAKS--IIHRDLKSNNIFLHEDLTVKIGDFGLATV------------L---SGS---ILWMAPEVIRM----QDKNPYSFQSDVYAFGIVLYELMT-GQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPK-------------------------------------------
34 PsiBlast_CBE 89.93100%-117 - C2 -3PSB B:[29-304] ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DDWEIPDGQITVGQRIGSGSFGTVYKGKWHG---D--VAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTK-PQ-LAIVTQWCEGSSLYHHLHI--IET-K-F-EMIKLIDIARQTAQGMDYLHAKS--IIHRDLKSNNIFLHEDLTVKIGDFGLATV------------L---SGS---ILWMAPEVIRM----QDKNPYSFQSDVYAFGIVLYELMT-GQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPK-------------------------------------------
12 PsiBlast_PDB 89.89100%-121 - C2 -3SKC BRAF_HUMAN A:[29-304] ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DDWEIPDGQITVGQRIGSGSFGTVYKGKWHG---D--VAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTK-PQ-LAIVTQWCEGSSLYHHLHI--IET-K-F-EMIKLIDIARQTAQGMDYLHAKS--IIHRDLKSNNIFLHEDLTVKIGDFG----------------L---SGS---ILWMAPEVIRM----QDKNPYSFQSDVYAFGIVLYELMT-GQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPK-------------------------------------------
14 PsiBlast_PDB 89.85100%-118 - C2 -3TV6 BRAF_HUMAN A:[29-304] ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DDWEIPDGQITVGQRIGSGSFGTVYKGKWHG---D--VAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTK-PQ-LAIVTQWCEGSSLYHHLHI--IET-K-F-EMIKLIDIARQTAQGMDYLHAKS--IIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWS-----------SGS---ILWMAPEVIRM----QDKNPYSFQSDVYAFGIVLYELMT-GQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPK-------------------------------------------
53 PsiBlast_CBE 89.7199%-117 - C2 -1UWH BRAF_HUMAN A:[1-276] ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DDWEIPDGQITVGQRIGSGSFGTVYKGKWHG---D--VAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTA-PQ-LAIVTQWCEGSSLYHHLHI--IET-K-F-EMIKLIDIARQTAQGMDYLHAKS--IIHRDLKSNNIFLHEDLTVKIGDFGLATV------------L---SGS---ILWMAPEVIRM----QDKNPYSFQSDVYAFGIVLYELMT-GQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPK-------------------------------------------
42 PsiBlast_CBE 89.6799%-120 - C2 -4EHG B:[29-304] ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DDWEIPDGQITVGQRIGSGSFGTVYKGKWHG---D--VAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTK-PQ-LAIVTQWCEGSSLYHHLHI--IET-K-F-EMIKLIDIARQTAQGMDYLHAKS--IIHRDLKSNNIFLHEDLTVKIGDFG----------------L---SGS---ILWMAPEVIRM----QDKNPYSFQSDVYAFGIVLYELMT-GQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPK-------------------------------------------
32 PsiBlast_CBE 89.39100%-113 - C2 -3SKC B:[29-304] ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DDWEIPDGQITVGQRIGSGSFGTVYKGKWHG---D--VAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTK-PQ-LAIVTQWCEGSSLYHHLHI--IET-K-F-EMIKLIDIARQTAQGMDYLHAKS--IIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQL---SGS---ILWMAPEVIRM----QDKNPYSFQSDVYAFGIVLYELMT-GQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPK-------------------------------------------
28 PsiBlast_CBE 89.19100%-115 - C2 -4E4X B:[29-302] ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DDWEIPDGQITVGQRIGSGSFGTVYKGKWHG---D--VAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTK-PQ-LAIVTQWCEGSSLYHHLHI--IET-K-F-EMIKLIDIARQTAQGMDYLHAKS--IIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQL---SGS---ILWMAPEVIRM----QDKNPYSFQSDVYAFGIVLYELMT-GQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSL---------------------------------------------
4 PsiBlast_PDB 89.17100%-115 - C2 -3D4Q BRAF_HUMAN A:[29-304] ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DDWEIPDGQITVGQRIGSGSFGTVYKGKWHG---D--VAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTK-PQ-LAIVTQWCEGSSLYHHLHI--IET-K-F-EMIKLIDIARQTAQGMDYLHAKS--IIHRDLKSNNIFLHEDLTVKIGDFGLATV------------L---SGS---ILWMAPEVIRM----QDKNPYSFQSDVYAFGIVLYELMT-GQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPK-------------------------------------------
46 PsiBlast_CBE 89.02100%-117 - C2 -4MBJ B:[29-304] ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DDWEIPDGQITVGQRIGSGSFGTVYKGKWHG---D--VAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTK-PQ-LAIVTQWCEGSSLYHHLHI--IET-K-F-EMIKLIDIARQTAQGMDYLHAKS--IIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQL---SGS---ILWMAPEVIRM----QDKNPYSFQSDVYAFGIVLYELMT-GQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPK-------------------------------------------
25 PsiBlast_CBE 88.71100%-114 - C2 -4PP7 B:[29-302] ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DDWEIPDGQITVGQRIGSGSFGTVYKGKWHG---D--VAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTK-PQ-LAIVTQWCEGSSLYHHLHI--IET-K-F-EMIKLIDIARQTAQGMDYLHAKS--IIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQL---SGS---ILWMAPEVIRM----QDKNPYSFQSDVYAFGIVLYELMT-GQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSL---------------------------------------------
18 PsiBlast_PDB 88.58100%-117 - C2 -4EHE BRAF_HUMAN A:[29-304] ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DDWEIPDGQITVGQRIGSGSFGTVYKGKWHG---D--VAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTK-PQ-LAIVTQWCEGSSLYHHLHI--IET-K-F-EMIKLIDIARQTAQGMDYLHAKS--IIHRDLKSNNIFLHEDLTVKIGDFGLATVKSR-------------SGS---ILWMAPEVIRM----QDKNPYSFQSDVYAFGIVLYELMT-GQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPK-------------------------------------------
63 PsiBlast_CBE 88.5793%-118 - C2 -3OG7 BRAF_HUMAN A:[18-288] ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DWEIPDGQITVGQRIGSGSFGTVYKGKWHG---D--VAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTA-PQ-LAIVTQWCEGSSLYHHLHA--S-----F-EMKKLIDIARQTARGMDYLHAKS--IIHRDLKSNNIFLHEDNTVKIGDFG---------------------GS---ILWMAPEVIR--------NPYSFQSDVYAFGIVLYELMT-GQLPYSNINNRDQIIEMVGRGSLSPDLSKVRSNCPKRMKRLMAECLKKKRDERPSFPRILAEIEELARE----------------------------------------------
64 PsiBlast_CBE 88.4894%-116 - C2 -4CQE ? B:[3-275] ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DDWEIPDGQITVGQRIGSG---TVYKGKWHG---D--VAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTK-PQ-LAIVTQWCEGSSLYHHLHA--SET-K-F-EMKKLIDIARQTARGMDYLHAKS--IIHRDLKSNNIFLHEDNTVKIGDFG---------------------GS---ILWMAPEVIR--------NPYSFQSDVYAFGIVLYELMT-GQLPYSNINNRDQIIEMVGRGSLSPDLSKVRSNCPKRMKRLMAECLKKKRDERPSFPRILAEIEELARE----------------------------------------------
3 PsiBlast_PDB 88.23100%-114 - C2 -3II5 BRAF_HUMAN A:[28-300] ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DDWEIPDGQITVGQRIGSGSFGTVYKGKWHG---D--VAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTK-PQ-LAIVTQWCEGSSLYHHLHI--IET-K-F-EMIKLIDIARQTAQGMDYLHAKS--IIHRDLKSNNIFLHEDLTVKIGDFGLATV-----------QL---SGS---ILWMAPEVIRM----QDKNPYSFQSDVYAFGIVLYELMT-GQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARS----------------------------------------------
62 PsiBlast_CBE 87.8394%-115 - C2 -4WO5 B:[27-298] -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------WEIPDGQITVGQRIGSGSFGTVYKGKWHG---D--VAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTK-PQ-LAIVTQWCEGSSLYHHLHA--SET-K-F-EMKKLIDIARQTARGMDYLHAKS--IIHRDLKSNNIFLHEDNTVKIGDFGLAT------------------GS---ILWMAPEVIRM----QDSNPYSFQSDVYAFGIVLYELMT-GQLPYSNINNRDQIIEMVGRGSLSPDLSKVRSNCPKRMKRLMAECLKKKRDERPSFPRILAEIEELAREL---------------------------------------------
41 PsiBlast_CBE 87.7099%-111 - C2 -4G9R B:[29-302] ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DDWEIPDGQITVGQRIGSGSFGTVYKGKWHG---D--VAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTK-PQ-LAIVTQWCEGSSLYHHLHI--IET-K-F-EMIKLIDIARQTAQGMDYLHAKS--IIHRDLKSNNIFLHEDLTVKIGDFGLATEK----------------GS---ILWMAPEVIRM----QDKNPYSFQSDVYAFGIVLYELMT-GQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSL---------------------------------------------
58 PsiBlast_CBE 87.6494%-118 - C2 -4JVG BRAF_HUMAN B:[9-282] ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DDWEIPDGQITVGQRIGSGSFGTVYKGKWHG---D--VAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTK-PQ-LAIVTQWCEGSSLYHHLHA--SET-K-F-EMKKLIDIARQTARGMDYLHAKS--IIHRDLKSNNIFLHEDNTVKIGDFGLAT-------------------S---ILWMAPEVIRM----QDSNPYSFQSDVYAFGIVLYELMT-GQLPYSNINNRDQIIEMVGRGSLSPDLSKVRSNCPKRMKRLMAECLKKKRDERPSFPRILAEIEELARELS--------------------------------------------
35 PsiBlast_CBE 87.25100%-115 - C2 -3PRI B:[29-304] ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DDWEIPDGQITVGQRIGSGSFGTVYKGKWHG---D--VAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTK-PQ-LAIVTQWCEGSSLYHHLHI--IET-K-F-EMIKLIDIARQTAQGMDYLHAKS--IIHRDLKSNNIFLHEDLTVKIGDFGLATV------------L---SGS---ILWMAPEVIRM----QDKNPYSFQSDVYAFGIVLYELMT-GQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPK-------------------------------------------
9 PsiBlast_PDB 87.25100%-115 - C2 -3PRI BRAF_HUMAN A:[29-304] ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DDWEIPDGQITVGQRIGSGSFGTVYKGKWHG---D--VAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTK-PQ-LAIVTQWCEGSSLYHHLHI--IET-K-F-EMIKLIDIARQTAQGMDYLHAKS--IIHRDLKSNNIFLHEDLTVKIGDFGLATV------------L---SGS---ILWMAPEVIRM----QDKNPYSFQSDVYAFGIVLYELMT-GQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPK-------------------------------------------
20 PsiBlast_PDB 87.2199%-111 - C2 -4G9R BRAF_HUMAN A:[29-302] ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DDWEIPDGQITVGQRIGSGSFGTVYKGKWHG---D--VAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTK-PQ-LAIVTQWCEGSSLYHHLHI--IET-K-F-EMIKLIDIARQTAQGMDYLHAKS--IIHRDLKSNNIFLHEDLTVKIGDFGLATEKS---------------GS---ILWMAPEVIRM----QDKNPYSFQSDVYAFGIVLYELMT-GQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSL---------------------------------------------
65 PsiBlast_CBE 86.6894%-112 - C2 -4CQE ? A:[4-275] ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DWEIPDGQITVGQRIGSG--GTVYKGKWHG---D--VAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTK-PQ-LAIVTQWCEGSSLYHHLHA--SET-K-F-EMKKLIDIARQTARGMDYLHAKS--IIHRDLKSNNIFLHEDNTVKIGDFG---------------------GS---ILWMAPEVIRM----Q--NPYSFQSDVYAFGIVLYELMT-GQLPYSNINNRDQIIEMVGRGSLSPDLSKVRSNCPKRMKRLMAECLKKKRDERPSFPRILAEIEELARE----------------------------------------------
54 PsiBlast_CBE 86.5399%-108 - C2 -1UWJ B:[1-276] ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DDWEIPDGQITVGQRIGSGSFGTVYKGKWHG---D--VAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTK-PQ-LAIVTQWCEGSSLYHHLHI--IET-K-F-EMIKLIDIARQTAQGMDYLHAKS--IIHRDLKSNNIFLHEDLTVKIGDFGLATEK----------------GS---ILWMAPEVIRM----QDKNPYSFQSDVYAFGIVLYELMT-GQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPK-------------------------------------------
57 PsiBlast_CBE 85.9094%-114 - C2 -