@TOME V2.3
(Nov 2016)
Ref.
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : CD11B_HUMAN: (2015-10-04 )
MGDEKDSWKVKTLDEILQEKKRRKEQEEKAEIKRLKNSDDRDSKRDSLEEGELRDHRMEITIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRKEKVHHRKDEKRKEKRRHRSHSAEGGKHARVKEKEREHERRKRHREEQDKARREWERQKRREMAREHSRRERDRLEQLERKRERERKMREQQKEQREQKERERRAEERRKEREARREVSAHHRTMREDYSDKVKASHWSRSPPRPPRERFELGDGRKPGEARPARAQKPAQLKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPESRFDRDSGESEEAEEEVGEGTPQSSALTEGDYVPDSPALSPIELKQELPKYLPALQGCRSVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQHPNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQLLRGVKHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVTLWYRAPELLLGAKEYSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQINKVFKDLGTPSEKIWPGYSELPAVKKMTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFRETPLPIDPSMFPTWPAKSEQQRVKRGTSPRPPEGGLGYSQLGDDDLKETGFHLTTTNQGASAAGPGFSLKF
Atome Classification :
(67 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450......--.460.......470.......480.......490.......500....---...510.......520.......530--.-......-.540.......550.......560.......570--.........580.......590........600.......610.......620.......630.-......640.----......650.......660.......670..--.....680--......---..690.......700.......710.......720......-.730.......740.......750.......760.......770.......780.......790...
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MGDEKDSW
K
V
K
T
L
D
E
I
L
Q
E
K
K
R
R
K
E
Q
E
E
K
A
E
I
K
R
LKNSDDRDSKRDSLEEGELRD
H
R
M
E
I
T
IRNSPYRREDSMEDRGEEDD
S
L
AIK
P
P
Q
Q
M
S
R
K
E
K
V
H
HR
K
D
E
K
R
K
E
K
R
RHRSHSAEGGKHA
R
V
K
E
K
E
R
E
H
E
R
R
K
R
H
R
E
E
Q
D
K
A
R
R
E
W
E
R
Q
K
R
R
E
M
A
R
E
H
S
R
R
E
R
D
R
L
E
Q
L
E
R
K
R
E
R
E
R
K
M
R
E
Q
Q
K
E
Q
R
E
Q
K
E
R
E
R
R
A
E
E
R
R
K
E
R
E
A
R
R
E
V
S
A
H
H
R
T
M
R
E
D
Y
S
D
K
VKASHWSRSPPRP
P
R
E
RFELGDGRKPGEARPARAQK
P
A
Q
L
K
E
E
K
M
E
E
R
D
L
L
S
D
L
Q
D
IS
D
S
ERKTSSAESSSAESGSGSE
E
E
E
E
E
E
E
E
E
EEEGSTSEESE
E
E
E
E
E
E
E
E
E
E
EETGSNS
E
E
A
S
E
Q
S
A
E
E
V
S
E
E
E
MSE
D
E
E
RENEN
H
L
L
V
VPESRFDRDSGE
S
E
E
A
E
E
E
VGEGTPQSSALTEGDYVPDSPAL
S
P
I
E
L
K
Q
E
L
P
K
Y
L
P
A
L
Q
G
C
R
S
V
E
E
F
Q
C
L
N
R
IEEGT
Y
G
V
V
Y
RAKDK--KT
D
E
I
V
A
L
K
R
L
K
M
E
K
EKEGFPI
T
S
L
R
E
I
N
T
I
L
KAQHP
N
I
V
T
V
R
E
I
VVG---SNM
D
K
I
Y
I
V
M
N
Y
V
E
H
D
L
K
S
L
M
E
T
M
K---Q-PFLP
G
E
-
V
K
T
L
M
I
Q
L
L
R
G
V
K
H
L
HDN
W
I
L
H
RDLKTS
N
L
L
L----SHA
G
I
L
K
VGD
F
G
L
A
R
EYGSP-LKAYT
P
V
V
V
T
L
WYRA
P
E
L
LLG
A
K
E
YS
T
A
V
D
M
W
S
V
G
C
I
F
G
E
L
L
T-QKPLFPG
K
S
E
----
I
D
Q
I
N
K
V
F
K
DLGTPSEKIWPG
Y
S
ELP
A
V
K
KM--TFSEH
P
-
Y
--
N
N
L
R
K
R
---
F
G
A
L
LSDQ
G
F
D
L
M
N
K
F
L
T
YFPGRRISAEDGL
K
H
E
Y
FRETPL-PIDPSMFPTWPAK
S
E
Q
Q
R
V
KRGTSPRPPEGGLGYSQLGD
D
D
L
K
ETG
F
H
L
T
TTNQGASAAGPGFSLKF
100
PsiBlast_CBE
92.50
44%
-99
- C1 -
2UZN
1
CDK2_HUMAN
A:
[1-293]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
---------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
---
E
N
--
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
A
---
L
-
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
-----------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
---
S
F
P
K
W
A
-
R
--
Q
D
F
S
K
V
---
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
-
P
V
P
H
L
R
L
------------------------------------------------------------
98
PsiBlast_CBE
91.82
44%
-92
- C1 -
2V0D
1
CDK2_HUMAN
A:
[1-293]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
L
------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
---
E
N
--
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
A
---
L
-
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
-
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
---
S
F
P
K
W
A
-
R
--
Q
D
F
S
K
V
---
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
-
P
V
P
H
L
R
L
------------------------------------------------------------
63
PsiBlast_CBE
91.79
44%
-93
- C1 -
3LFQ
1
CDK2_HUMAN
A:
[1-293]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
---------
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
---
E
N
--
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
A
---
L
-
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
-
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
---
S
F
P
K
W
A
-
R
--
Q
D
F
S
K
V
---
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
-
P
V
P
H
L
R
L
------------------------------------------------------------
88
PsiBlast_CBE
91.68
44%
-96
- C1 -
2VTQ
1
CDK2_HUMAN
A:
[1-293]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
---------
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
---
E
N
--
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
A
---
L
-
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
E
G
A
I
K
L
A
D
F
G
----------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
---
S
F
P
K
W
A
-
R
--
Q
D
F
S
K
V
---
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
-
P
V
P
H
L
R
L
------------------------------------------------------------
61
PsiBlast_CBE
91.67
44%
-93
- C1 -
3NS9
1
CDK2_HUMAN
A:
[3-293]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
-------
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
---
E
N
--
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
A
---
L
-
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
-
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
---
S
F
P
K
W
A
-
R
--
Q
D
F
S
K
V
---
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
-
P
V
P
H
L
R
L
------------------------------------------------------------
51
PsiBlast_CBE
91.62
44%
-93
- C1 -
3WBL
1
CDK2_HUMAN
A:
[1-293]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
---
T
G
E
V
V
A
L
K
K
I
R
L
-----
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
---
E
N
--
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
A
---
L
-
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
----------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
---
S
F
P
K
W
A
-
R
--
Q
D
F
S
K
V
---
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
-
P
V
P
H
L
R
L
------------------------------------------------------------
92
PsiBlast_CBE
91.52
44%
-94
- C1 -
2VTM
1
CDK2_HUMAN
A:
[1-293]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
--------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
---
E
N
--
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
A
---
L
-
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
-
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
---
S
F
P
K
W
A
-
R
--
Q
D
F
S
K
V
---
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
-
P
V
P
H
L
R
L
------------------------------------------------------------
50
PsiBlast_CBE
91.51
44%
-99
- C1 -
4BGH
1
CDK2_HUMAN
A:
[1-293]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
---------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
---
E
N
--
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
A
---
L
-
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
E
G
A
I
K
L
A
D
F
G
L
A
---------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
---
S
F
P
K
W
A
-
R
--
Q
D
F
S
K
V
---
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
-
P
V
P
H
L
R
L
------------------------------------------------------------
90
PsiBlast_CBE
91.50
44%
-94
- C1 -
2VTO
1
CDK2_HUMAN
A:
[1-293]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
-------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
---
E
N
--
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
A
---
L
-
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
---------
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
---
S
F
P
K
W
A
-
R
--
Q
D
F
S
K
V
---
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
-
P
V
P
H
L
R
L
------------------------------------------------------------
94
PsiBlast_CBE
91.27
44%
-97
- C1 -
2VTJ
2
CDK2_HUMAN
A:
[1-293]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
---------
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
---
E
N
--
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
A
---
L
-
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
--------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
---
S
F
P
K
W
A
-
R
--
Q
D
F
S
K
V
---
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
-
P
V
P
H
L
R
L
------------------------------------------------------------
95
PsiBlast_CBE
91.21
44%
-96
- C1 -
2VTI
1
CDK2_HUMAN
A:
[1-293]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
--------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
---
E
N
--
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
A
---
L
-
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
-----------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
---
S
F
P
K
W
A
-
R
--
Q
D
F
S
K
V
---
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
-
P
V
P
H
L
R
L
------------------------------------------------------------
67
PsiBlast_CBE
91.17
44%
-94
- C1 -
3FZ1
1
CDK2_HUMAN
A:
[1-293]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
-------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
---
E
N
--
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
A
---
L
-
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
--------
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
---
S
F
P
K
W
A
-
R
--
Q
D
F
S
K
V
---
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
-
P
V
P
H
L
R
L
------------------------------------------------------------
64
PsiBlast_CBE
90.98
44%
-93
- C1 -
3LFN
1
CDK2_HUMAN
A:
[1-293]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
---
E
N
--
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
A
---
L
-
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
----------
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
---
S
F
P
K
W
A
-
R
--
Q
D
F
S
K
V
---
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
-
P
V
P
H
L
R
L
------------------------------------------------------------
49
PsiBlast_CBE
90.95
44%
-98
- C1 -
4BZD
1
CDK2_HUMAN
A:
[2-294]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
-
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
L
------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
---
E
N
--
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
A
---
L
-
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
E
G
A
I
K
L
A
D
F
G
L
---------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
---
S
F
P
K
W
A
-
R
--
Q
D
F
S
K
V
---
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
-
P
V
P
H
L
R
L
------------------------------------------------------------
57
PsiBlast_CBE
90.89
44%
-93
- C1 -
3TI1
9
CDK2_HUMAN
A:
[1-293]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
---
E
N
--
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
A
---
L
-
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
-
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
---
S
F
P
K
W
A
-
R
--
Q
D
F
S
K
V
---
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
-
P
V
P
H
L
R
L
------------------------------------------------------------
74
PsiBlast_CBE
90.83
44%
-89
- C1 -
2XNB
1
CDK2_HUMAN
A:
[1-293]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
L
D
--
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
---
E
N
--
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
A
---
L
-
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
-
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
---
S
F
P
K
W
A
-
R
--
Q
D
F
S
K
V
---
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
-
P
V
P
H
L
R
L
------------------------------------------------------------
48
PsiBlast_CBE
90.83
44%
-96
- C1 -
4D1X
1
CDK2_HUMAN
A:
[3-293]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
-----------
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
---
E
N
--
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
A
---
L
-
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
------------
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
---
S
F
P
K
W
A
-
R
--
Q
D
F
S
K
V
---
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
-
P
V
P
H
L
R
L
------------------------------------------------------------
97
PsiBlast_CBE
90.79
44%
-90
- C1 -
2VTA
3
CDK2_HUMAN
A:
[1-293]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
---------
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
---
E
N
--
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
A
---
L
-
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
---
S
F
P
K
W
A
-
R
--
Q
D
F
S
K
V
---
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
-
P
V
P
H
L
R
L
------------------------------------------------------------
93
PsiBlast_CBE
90.70
44%
-93
- C1 -
2VTL
1
CDK2_HUMAN
A:
[1-293]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
--------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
---
E
N
--
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
A
---
L
-
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
-
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
---
S
F
P
K
W
A
-
R
--
Q
D
F
S
K
V
---
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
-
P
V
P
H
L
R
L
------------------------------------------------------------
99
PsiBlast_CBE
90.61
44%
-93
- C1 -
2UZO
1
CDK2_HUMAN
A:
[1-293]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
L
------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
---
E
N
--
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
A
---
L
-
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
-
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
---
S
F
P
K
W
A
-
R
--
Q
D
F
S
K
V
---
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
-
P
V
P
H
L
--------------------------------------------------------------
96
PsiBlast_CBE
90.60
44%
-95
- C1 -
2VTH
2
CDK2_HUMAN
A:
[1-293]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
---------
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
---
E
N
--
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
A
---
L
-
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
---
S
F
P
K
W
A
-
R
--
Q
D
F
S
K
V
---
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
-
P
V
P
H
L
R
L
------------------------------------------------------------
62
PsiBlast_CBE
90.58
44%
-92
- C1 -
3LFS
1
CDK2_HUMAN
A:
[1-293]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
--------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
---
E
N
--
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
A
---
L
-
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
-
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
---
S
F
P
K
W
A
-
R
--
Q
D
F
S
K
V
---
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
-
P
V
P
H
L
R
L
------------------------------------------------------------
75
PsiBlast_CBE
90.56
44%
-92
- C1 -
2XMY
1
CDK2_HUMAN
A:
[1-293]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
---
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
---
E
N
--
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
A
---
L
-
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
-
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
---
S
F
P
K
W
A
-
R
--
Q
D
F
S
K
V
---
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
-
P
V
P
H
L
R
L
------------------------------------------------------------
87
PsiBlast_CBE
90.51
44%
-90
- C1 -
2VTR
1
CDK2_HUMAN
A:
[1-293]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
--------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
---
E
N
--
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
A
---
L
-
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
-
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
---
S
F
P
K
W
A
-
R
--
Q
D
F
S
K
V
---
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
-
P
V
P
H
L
R
L
------------------------------------------------------------
82
PsiBlast_CBE
90.43
44%
-96
- C1 -
2W06
2
CDK2_HUMAN
A:
[1-293]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
-------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
---
E
N
--
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
A
---
L
-
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
----------
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
---
S
F
P
K
W
A
-
R
--
Q
D
F
S
K
V
---
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
-
P
V
P
H
L
R
L
------------------------------------------------------------
73
PsiBlast_CBE
90.43
44%
-91
- C1 -
3EID
1
CDK2_HUMAN
A:
[1-293]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
L
---
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
---
E
N
--
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
A
---
L
-
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
-
V
R
T
Y
T
--
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
---
S
F
P
K
W
A
-
R
--
Q
D
F
S
K
V
---
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
-
P
V
P
H
L
R
-------------------------------------------------------------
86
PsiBlast_CBE
90.33
44%
-93
- C1 -
2VTS
1
CDK2_HUMAN
A:
[1-293]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
--------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
---
E
N
--
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
A
---
L
-
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
---------
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
---
S
F
P
K
W
A
-
R
--
Q
D
F
S
K
V
---
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
-
P
V
P
H
L
R
L
------------------------------------------------------------
71
PsiBlast_CBE
90.33
44%
-90
- C1 -
3EJ1
1
CDK2_HUMAN
C:
[1-293]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
L
---
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
---
E
N
--
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
A
---
L
-
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
-
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
---
S
F
P
K
W
A
-
R
--
Q
D
F
S
K
V
---
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
-
P
V
P
H
L
R
-------------------------------------------------------------
52
PsiBlast_CBE
90.14
44%
-91
- C1 -
3UNK
1
CDK2_HUMAN
A:
[1-293]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
---
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
---
E
N
--
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
A
---
L
-
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
-
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
---
S
F
P
K
W
A
-
R
--
Q
D
F
S
K
V
---
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
-
P
V
P
H
L
R
L
------------------------------------------------------------
55
PsiBlast_CBE
90.04
44%
-92
- C1 -
3TIZ
9
CDK2_HUMAN
A:
[2-293]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
---
E
N
--
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
A
---
L
-
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
-
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
---
S
F
P
K
W
A
-
R
--
Q
D
F
S
K
V
---
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
-
P
V
P
H
L
R
L
------------------------------------------------------------
56
PsiBlast_CBE
90.01
44%
-91
- C1 -
3TIY
12
CDK2_HUMAN
A:
[2-293]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
---
E
N
--
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
A
---
L
-
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
-
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
---
S
F
P
K
W
A
-
R
--
Q
D
F
S
K
V
---
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
-
P
V
P
H
L
R
L
------------------------------------------------------------
85
PsiBlast_CBE
90.00
44%
-94
- C1 -
2VU3
1
CDK2_HUMAN
A:
[1-293]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
L
---------
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
---
E
N
--
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
A
---
L
-
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
E
G
A
I
K
L
A
D
F
G
----
F
G
V
P
-
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
---
S
F
P
K
W
A
-
R
--
Q
D
F
S
K
V
---
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
-
P
V
P
H
L
R
L
------------------------------------------------------------
60
PsiBlast_CBE
89.93
44%
-97
- C1 -
3S2P
1
CDK2_HUMAN
A:
[1-293]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
--------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
---
E
N
--
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
A
---
L
-
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
---
S
F
P
K
W
A
-
R
--
Q
D
F
S
K
V
---
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
-
P
V
P
H
L
R
L
------------------------------------------------------------
80
PsiBlast_CBE
89.91
44%
-90
- C1 -
2W1H
1
CDK2_HUMAN
A:
[1-293]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
---
E
N
--
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
A
---
L
-
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
---
S
F
P
K
W
A
-
R
--
Q
D
F
S
K
V
---
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
-
P
V
P
H
L
R
L
------------------------------------------------------------
91
PsiBlast_CBE
89.85
44%
-91
- C1 -
2VTN
1
CDK2_HUMAN
A:
[1-293]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
--------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
---
E
N
--
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
A
---
L
-
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
E
G
A
I
K
L
A
D
F
G
-----------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
---
S
F
P
K
W
A
-
R
--
Q
D
F
S
K
V
---
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
-
P
V
P
H
L
R
L
------------------------------------------------------------
89
PsiBlast_CBE
89.84
44%
-94
- C1 -
2VTP
1
CDK2_HUMAN
A:
[1-293]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
--------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
---
E
N
--
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
A
---
L
-
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
----------
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
---
S
F
P
K
W
A
-
R
--
Q
D
F
S
K
V
---
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
-
P
V
P
H
L
R
L
------------------------------------------------------------
72
PsiBlast_CBE
89.68
44%
-93
- C1 -
3EJ1
1
CDK2_HUMAN
A:
[1-293]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
L
---
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
---
E
N
--
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
A
---
L
-
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
-
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
---
S
F
P
K
W
A
-
R
--
Q
D
F
S
K
V
---
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
-
P
V
P
H
L
R
L
------------------------------------------------------------
68
PsiBlast_CBE
89.44
44%
-86
- C1 -
3F5X
2
CDK2_HUMAN
C:
[1-293]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
---
E
N
--
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
A
---
L
-
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
-
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
---
S
F
P
K
W
A
-
R
--
Q
D
F
S
K
V
---
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
-
P
V
P
H
L
R
L
------------------------------------------------------------
76
PsiBlast_CBE
89.43
44%
-86
- C1 -
2X1N
1
CDK2_HUMAN
C:
[1-293]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
---
E
N
--
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
A
---
L
-
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
-
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
---
S
F
P
K
W
A
-
R
--
Q
D
F
S
K
V
---
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
-
P
V
P
H
L
R
-------------------------------------------------------------
54
PsiBlast_CBE
89.40
44%
-95
- C1 -
3ULI
1
CDK2_HUMAN
A:
[1-293]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-----
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
---
E
N
--
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
A
---
L
-
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
--------
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
---
S
F
P
K
W
A
-
R
--
Q
D
F
S
K
V
---
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
-
P
V
P
H
L
R
L
------------------------------------------------------------
83
PsiBlast_CBE
89.36
44%
-99
- C1 -
2W05
1
CDK2_HUMAN
A:
[1-293]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
---------
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
---
E
N
--
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
A
---
L
-
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
E
G
A
I
K
L
A
D
F
G
L
--------------
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
---
S
F
P
K
W
A
-
R
--
Q
D
F
S
K
V
---
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
-
P
V
P
H
L
R
L
------------------------------------------------------------
53
PsiBlast_CBE
89.22
44%
-92
- C1 -
3UNJ
1
CDK2_HUMAN
A:
[1-293]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
---
E
N
--
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
A
---
L
-
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
-
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
---
S
F
P
K
W
A
-
R
--
Q
D
F
S
K
V
---
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
-
P
V
P
H
L
R
L
------------------------------------------------------------
120
HHSearch
89.16
41%
-74
- C1 -
4NST
3
CDK12_HUMAN
A:
[8-329]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
K
R
C
V
D
K
F
D
I
I
G
I
I
G
E
G
T
Y
G
Q
V
Y
K
A
K
D
K
--
D
T
G
E
L
V
A
L
K
K
V
R
L
D
N
E
K
E
G
F
P
I
T
A
I
R
E
I
K
I
L
R
Q
L
I
H
R
S
V
V
N
M
K
E
I
V
T
D
KQD---
G
A
F
Y
L
V
F
E
Y
M
D
H
D
L
M
G
L
L
E
S
G
L
---
V
-
H
F
S
E
D
H
-
I
K
S
F
M
K
Q
L
M
E
G
L
E
Y
C
H
K
K
N
F
L
H
R
D
I
K
C
S
N
I
L
L
----
N
N
S
G
Q
I
K
L
A
D
F
G
L
A
R
L
Y
N
S
E
E
S
R
P
Y
T
N
K
V
I
T
L
W
Y
R
P
P
E
L
L
L
G
E
E
R
Y
T
P
A
I
D
V
W
S
C
G
C
I
L
G
E
L
F
T
-
K
K
P
I
F
Q
A
N
L
E
----
L
A
Q
L
E
L
I
S
R
L
C
G
S
P
C
P
A
V
W
P
D
V
I
K
L
P
Y
F
N
T
M
--
K
P
K
K
Q
Y
-
R
--
R
R
L
R
E
E
---
F
S
-
F
I
P
S
A
A
L
D
L
L
D
H
M
L
T
L
D
P
S
K
R
C
T
A
E
Q
T
L
Q
S
D
F
L
K
D
V
E
L
S
K
M
A
P
P
D
L
P
H
W
Q
D
C
H
E
L
W
S
K
K
-----------------------------------------------
78
PsiBlast_CBE
89.13
44%
-87
- C1 -
2WEV
1
CDK2_HUMAN
C:
[1-293]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
---
E
N
--
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
A
---
L
-
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
-
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
---
S
F
P
K
W
A
-
R
--
Q
D
F
S
K
V
---
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
-
P
V
P
H
L
R
-------------------------------------------------------------
79
PsiBlast_CBE
88.83
44%
-90
- C1 -
2WEV
1
CDK2_HUMAN
A:
[1-293]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
---
E
N
--
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
A
---
L
-
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
-
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
---
S
F
P
K
W
A
-
R
--
Q
D
F
S
K
V
---
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
-
P
V
P
H
L
--------------------------------------------------------------
69
PsiBlast_CBE
88.63
44%
-91
- C1 -
3F5X
2
CDK2_HUMAN
A:
[1-293]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
---
E
N
--
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
A
---
L
-
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
-
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
---
S
F
P
K
W
A
-
R
--
Q
D
F
S
K
V
---
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
-
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
-
P
V
P
H
L
R
L
------------------------------------------------------------
70
PsiBlast_CBE
88.52
44%
-91
- C1 -
3EOC
1
CDK2_HUMAN
A:
[1-293]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
L
---
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
---
E
N
--
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
A
---
L
-
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
-
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
---
S
F
P
K
W
A
-
R
--
Q
D
F
S
K
V
---
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
-
P
V
P
H
L
R
L
------------------------------------------------------------
77
PsiBlast_CBE
88.03
44%
-86
- C1 -
2X1N
1
CDK2_HUMAN
A:
[1-293]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
---
E
N
--
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
A
---
L
-
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
-
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
---
S
F
P
K
W
A
-
R
--
Q
D
F
S
K
V
---
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
-
P
V
P
H
L
--------------------------------------------------------------
114
HHSearch
83.00
40%
-85
- C1 -
4F6U
10
CDK8_HUMAN
A:
[28-346]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
V
G
R
G
T
Y
G
H
V
Y
K
A
K
R
K
DG
K
D
D
K
D
Y
A
L
K
Q
I
E
----
G
T
G
I
S
M
S
A
C
R
E
I
A
L
L
R
E
L
K
H
P
N
V
I
S
L
Q
K
V
F
L
S
---
H
A
D
R
K
V
W
L
L
F
D
Y
A
E
H
D
L
W
H
I
I
K
F
H
R
A
S
K
V
-
Q
L
P
R
G
M
-
V
K
S
L
L
Y
Q
I
L
D
G
I
H
Y
L
H
A
N
W
V
L
H
R
D
L
K
P
A
N
I
L
V
M
G
EG
P
E
R
G
R
V
K
I
A
D
M
G
F
---------------
V
V
T
F
W
Y
R
A
P
E
L
L
L
G
A
R
H
Y
T
K
A
I
D
I
W
A
I
G
C
I
F
A
E
L
L
T
-
S
E
P
I
F
H
C
R
Q
E
NPYH
H
D
Q
L
D
R
I
F
N
V
M
G
F
P
A
D
K
D
W
E
D
I
K
K
M
P
E
H
S
T
L
M
K
D
F
R
R
N
T
-
Y
TN
C
S
L
I
K
Y
M
E
K
H
K
V
K
P
D
S
K
A
F
H
L
L
Q
K
L
L
T
M
D
P
I
K
R
I
T
S
E
Q
A
M
Q
D
P
Y
F
L
E
D
P
L
-
P
T
S
D
V
F
A
G
C
Q
I
P
Y
P
K
R
E
F
L
------------------------------------------------
129
HHSearch
81.70
42%
-83
- C1 -
4AU8
2
CDK5_HUMAN
A:
[6-293]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
K
Y
E
K
L
E
K
I
G
E
G
T
Y
G
T
V
F
K
A
K
N
R
--
E
T
H
E
I
V
A
L
K
R
V
---------
P
S
S
A
L
R
E
I
C
L
L
K
E
L
K
H
K
N
I
V
R
L
H
D
V
L
H
--------
K
L
T
L
V
F
E
F
C
D
Q
D
L
K
K
Y
F
D
S
C
N
---
G
-
D
L
D
P
E
I
-
V
K
S
F
L
F
Q
L
L
K
G
L
G
F
C
H
S
R
N
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
R
N
G
E
L
K
L
A
D
F
G
L
A
R
A
F
G
I
P
-
V
R
--
S
A
E
V
V
T
L
W
Y
R
P
P
D
V
L
F
G
A
K
L
Y
S
T
S
I
D
M
W
S
A
G
C
I
F
A
E
L
A
N
A
G
R
P
L
F
P
G
N
D
V
----
D
D
Q
L
K
R
I
F
R
L
L
G
T
P
T
E
E
Q
W
P
S
M
T
K
L
P
D
Y
K
P
----
Y
P
M
Y
P
-
A
--
T
T
S
L
V
N
---
V
V
P
K
L
N
A
T
G
R
D
L
L
Q
N
L
L
K
C
N
P
V
Q
R
I
S
A
E
E
A
L
Q
H
P
Y
F
S
D
F
----------------------------------------------------------------------
111
HHSearch
81.69
42%
-81
- C1 -
1UA2
1
CDK7_HUMAN
A:
[13-305]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
K
L
D
F
L
G
E
G
Q
F
A
T
V
Y
K
A
R
D
K
--
N
T
N
Q
I
V
A
I
K
K
I
---------
N
R
T
A
L
R
E
I
K
L
L
Q
E
L
S
H
P
N
I
I
G
L
L
D
A
F
G
-----
H
K
S
N
I
S
L
V
F
D
F
M
E
T
D
L
E
V
I
I
K
D
N
S
---
L
-
V
L
T
P
S
H
-
I
K
A
Y
M
L
M
T
L
Q
G
L
E
Y
L
H
Q
H
W
I
L
H
R
D
L
K
P
N
N
L
L
L
----
D
E
N
G
V
L
K
L
A
D
F
G
L
A
K
S
F
G
S
P
-
N
R
A
Y
T
H
Q
V
V
T
R
W
Y
R
A
P
E
L
L
F
G
A
R
M
Y
G
V
G
V
D
M
W
A
V
G
C
I
L
A
E
L
L
L
-
R
V
P
F
L
P
G
D
S
D
----
L
D
Q
L
T
R
I
F
E
T
L
G
T
P
T
E
E
Q
W
P
D
M
C
S
L
P
D
Y
--
V
--
T
F
K
S
F
P
-
G
--
I
P
L
H
H
I
---
F
S
A
-
A
G
D
D
L
L
D
L
I
Q
G
L
F
L
F
N
P
C
A
R
I
T
A
T
Q
A
L
K
M
K
Y
F
S
N
R
P
G
-
P
T
P
G
C
Q
L
P
R
P
N
--------------------------------------------------------
131
HHSearch
80.52
36%
-80
- C1 -
2B9H
1
FUS3_YEAST
A:
[10-315]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
S
D
F
Q
L
K
S
L
L
G
E
G
A
Y
G
V
V
C
S
A
T
H
K
--
P
T
G
E
I
V
A
I
K
K
I
E
P
F
-
D
K
P
L
F
A
L
R
T
L
R
E
I
K
I
L
K
H
F
K
H
E
N
I
I
T
I
F
N
I
Q
R
P
DSF
E
N
F
N
E
V
Y
I
I
Q
E
L
M
Q
T
D
L
H
R
V
I
S
T
-----
Q
-
M
L
S
D
D
H
-
I
Q
Y
F
I
Y
Q
T
L
R
A
V
K
V
L
H
G
S
N
V
I
H
R
D
L
K
P
S
N
L
L
I
----
N
S
N
C
D
L
K
V
C
D
F
G
L
A
R
I
I
D
-------
V
E
F
V
A
T
R
W
Y
R
A
P
E
V
M
L
T
S
A
K
Y
S
R
A
M
D
V
W
S
C
G
C
I
L
A
E
L
F
L
-
R
R
P
I
F
P
G
R
D
Y
----
R
H
Q
L
L
L
I
F
G
I
I
G
T
P
H
S
D
N
D
L
R
C
I
E
S
P
R
A
R
E
Y
I
K
S
L
P
M
Y
P
-
A
--
A
P
L
E
K
M
---
F
P
-
R
V
N
P
K
G
I
D
L
L
Q
R
M
L
V
F
D
P
A
K
R
I
T
A
K
E
A
L
E
H
P
Y
L
Q
T
Y
H
D
-
P
N
D
E
P
E
G
E
P
I
P
P
S
F
F
E
F
D
H
Y
K
E
A
L
T
T
K
D
L
K
K
L
I
W
N
E
I
F
S
----------------------------
126
HHSearch
79.16
39%
-83
- C1 -
4BGQ
3
CDKL5_HUMAN
A:
[11-303]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
N
K
F
E
I
L
G
V
V
G
E
G
A
Y
G
V
V
L
K
C
R
H
K
--
E
T
H
E
I
V
A
I
K
K
F
K
-------
V
K
E
T
T
L
R
E
L
K
M
L
R
T
L
K
Q
E
N
I
V
E
L
K
E
A
F
R
R
-----
R
G
K
L
Y
L
V
F
E
Y
V
E
K
N
M
L
E
L
L
E
E
M
P
---
N
-
G
V
P
P
E
K
-
V
K
S
Y
I
Y
Q
L
I
K
A
I
H
W
C
H
K
N
D
I
V
H
R
D
I
K
P
E
N
L
L
I
----
S
H
N
D
V
L
K
L
C
D
F
G
F
A
R
N
L
S
E
-----------
T
R
W
Y
R
S
P
E
L
L
L
G
-
A
P
Y
G
K
S
V
D
M
W
S
V
G
C
I
L
G
E
L
S
D
-
G
Q
P
L
F
P
G
E
S
E
----
I
D
Q
L
F
T
I
Q
K
V
L
G
P
L
P
S
E
Q
M
K
L
F
Y
S
N
P
R
F
H
G
L
--
R
F
P
A
V
N
H
P
--
Q
S
L
E
R
R
---
Y
L
G
I
L
N
S
V
L
L
D
L
M
K
N
L
L
K
L
D
P
A
D
R
Y
L
T
E
Q
C
L
N
H
P
T
F
Q
T
Q
R
L
--------------------------------------------------------------------
122
HHSearch
63.00
45%
27
* C1 *
4EK4
1
CDK2_HUMAN
A:
[4-294]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
---------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
-----
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
A
---
L
T
G
I
P
L
P
L
-
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
-
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
---
S
F
P
K
W
A
-
R
--
Q
D
F
S
K
V
---
V
-
P
P
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
-
P
V
P
H
L
--------------------------------------------------------------
38
PsiBlast_CBE
62.18
44%
28
- C1 -
4FKQ
2
CDK2_HUMAN
A:
[4-294]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
L
------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
---
E
N
--
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
A
---
L
-
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
----------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
---
S
F
P
K
W
A
-
R
--
Q
D
F
S
K
V
---
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
-
P
V
P
H
L
R
L
------------------------------------------------------------
46
PsiBlast_CBE
62.05
44%
30
- C1 -
4EK5
1
CDK2_HUMAN
A:
[4-294]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
---------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
---
E
N
--
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
A
---
L
-
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
-
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
---
S
F
P
K
W
A
-
R
--
Q
D
F
S
K
V
---
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
-
P
V
P
H
L
R
L
------------------------------------------------------------
84
PsiBlast_CBE
61.85
44%
29
- C1 -
2VV9
1
CDK2_HUMAN
A:
[4-294]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
L
------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
---
E
N
--
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
A
---
L
-
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
E
G
A
I
K
L
A
D
F
G
L
A
--------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
---
S
F
P
K
W
A
-
R
--
Q
D
F
S
K
V
---
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
-
P
V
P
H
L
R
L
------------------------------------------------------------
43
PsiBlast_CBE
61.59
44%
32
- C1 -
4FKG
1
CDK2_HUMAN
A:
[4-294]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
---------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
---
E
N
--
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
A
---
L
-
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
----
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
---
S
F
P
K
W
A
-
R
--
Q
D
F
S
K
V
---
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
-
P
V
P
H
L
R
L
------------------------------------------------------------
40
PsiBlast_CBE
61.56
44%
33
- C1 -
4FKO
1
CDK2_HUMAN
A:
[4-294]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
L
-------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
---
E
N
--
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
A
---
L
-
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
-
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
---
S
F
P
K
W
A
-
R
--
Q
D
F
S
K
V
---
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
-
P
V
P
H
L
R
L
------------------------------------------------------------
37
PsiBlast_CBE
61.48
44%
32
- C1 -
4FKR
2
CDK2_HUMAN
A:
[4-294]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
L
-------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
---
E
N
--
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
A
---
L
-
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
----------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
---
S
F
P
K
W
A
-
R
--
Q
D
F
S
K
V
---
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
-
P
V
P
H
L
R
L
------------------------------------------------------------
42
PsiBlast_CBE
61.45
44%
31
- C1 -
4FKJ
1
CDK2_HUMAN
A:
[4-294]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
---------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
---
E
N
--
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
A
---
L
-
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
---
S
F
P
K
W
A
-
R
--
Q
D
F
S
K
V
---
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
-
P
V
P
H
L
R
L
------------------------------------------------------------
36
PsiBlast_CBE
61.35
44%
28
- C1 -
4FKV
2
CDK2_HUMAN
A:
[4-294]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
L
-----
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
---
E
N
--
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
A
---
L
-
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
------------
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
---
S
F
P
K
W
A
-
R
--
Q
D
F
S
K
V
---
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
-
P
V
P
H
L
R
L
------------------------------------------------------------
58
PsiBlast_CBE
61.34
44%
31
- C1 -
3SW7
1
CDK2_HUMAN
A:
[4-294]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
L
-------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
---
E
N
--
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
A
---
L
-
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
E
G
A
I
K
L
A
D
F
G
L
A
--------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
---
S
F
P
K
W
A
-
R
--
Q
D
F
S
K
V
---
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
-
P
V
P
H
L
R
L
------------------------------------------------------------
45
PsiBlast_CBE
60.90
44%
29
- C1 -
4EK6
1
CDK2_HUMAN
A:
[4-294]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
----------
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
---
E
N
--
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
A
---
L
-
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
-----------
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
---
S
F
P
K
W
A
-
R
--
Q
D
F
S
K
V
---
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
-
P
V
P
H
L
R
L
------------------------------------------------------------
65
PsiBlast_CBE
60.68
44%
31
- C1 -
3IGG
1
CDK2_HUMAN
A:
[4-294]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
--------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
---
E
N
--
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
A
---
L
-
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
-
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
---
S
F
P
K
W
A
-
R
--
Q
D
F
S
K
V
---
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
-
P
V
P
H
L
R
L
------------------------------------------------------------
66
PsiBlast_CBE
60.09
44%
33
- C1 -
3IG7
1
CDK2_HUMAN
A:
[4-294]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
--------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
---
E
N
--
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
A
---
L
-
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
-------------
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
---
S
F
P
K
W
A
-
R
--
Q
D
F
S
K
V
---
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
-
P
V
P
H
L
R
L
------------------------------------------------------------
81
PsiBlast_CBE
48.52
44%
29
- C1 -
2W17
1
CDK2_HUMAN
A:
[4-294]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
-
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-----
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
---
E
---
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
A
---
L
-
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
E
G
A
I
K
L
A
D
F
G
L
A
--------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
---
S
F
P
K
W
A
-
R
--
Q
D
F
S
K
V
---
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
-
P
V
P
H
L
R
L
------------------------------------------------------------