@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : CDK10_HUMAN: (2015-10-04 )
MAEPDLECEQIRLKCIRKEGFFTVPPEHRLGRCRSVKEFEKLNRIGEGTYGIVYRARDTQTDEIVALKKVRMDKEKDGIPISSLREITLLLRLRHPNIVELKEVVVGNHLESIFLVMGYCEQDLASLLENMPTPFSEAQVKCIVLQVLRGLQYLHRNFIIHRDLKVSNLLMTDKGCVKTADFGLARAYGVPVKPMTPKVVTLWYRAPELLLGTTTQTTSIDMWAVGCILAELLAHRPLLPGTSEIHQIDLIVQLLGTPSENIWPGFSKLPLVGQYSLRKQPYNNLKHKFPWLSEAGLRLLHFLFMYDPKKRATAGDCLESSYFKEKPLPCEPELMPTFPHHRNKRAAPATSEGQSKRCKP
Atome Classification :
(107 SA)
.........10........20........30........40........50.......--.60........70........80........90........100.....----.--.---110-..-.......120..-----.....130---..-.......140.......150.......160.......170---........180.......190.----.......200.......210.......220.......230..-----------.....240.-------.----.....250.......260.......270...--....--280....------...290.......300.......310.......320...--....330.......340.......350.......360
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MAEPDL
E
C
E
Q
I
R
L
K
C
I
RKEG
F
F
TVPP
E
H
R
L
G
R
C
R
S
V
K
E
F
E
K
L
N
R
IGEG
T
Y
G
I
V
Y
R
ARD--TQT
D
E
I
V
A
L
K
K
V
RMDKEKDGI
P
I
S
S
L
R
E
I
T
L
L
LRLRHP
N
I
V
E
L
K
E
V
V
V
G
----
N
--
H
---
L
---
E
S
-
I
F
L
V
M
G
Y
C
E
Q
D
L
-----
A
S
L
L
E
N-----MP-TPF
S
E
A
Q
V
K
C
I
V
L
Q
V
L
R
G
L
Q
Y
L
H
RN
F
I
I
H
RD
L
K
V
S
N
L
L
M----TDKGCV
K
T
A
DFG
L
A
R
AYGVP-V----KPMTP
K
V
V
T
L
W
YRA
P
E
L
L
L
GTTTQ
T
T
S
I
D
M
W
A
V
G
C
I
L
A
E
L
L
A-----------HRPLLPGT
S
-------
E
----
I
H
Q
I
D
L
I
V
Q
L
LGTPSENIWPGFSKL
P
L
VGQY--SLRK--QP
Y
N
N
L
K
------
H
KFP
W
L
S
E
A
G
L
R
L
L
H
F
L
F
MYDPKKRATA
G
D
C
L
E
S
S
YFKE--KPLPCEPELMPTFPHHRNKRAAPATSEGQSKRCKP
71
PsiBlast_CBE
97.03
45%
-124
- C1 -
3QZH
2
CDK2_HUMAN
A:
[9-302]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
--
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------
H
---
T
---
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
A
L
T
G
-----
I
P
-
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
-
V
----
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
-
K
P
--
S
F
P
K
--
W
A
R
Q
D
F
S
------
K
V
V
P
P
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
---------------------------
69
PsiBlast_CBE
96.46
45%
-122
- C1 -
3R1Q
2
CDK2_HUMAN
A:
[9-302]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
--
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------
H
---
T
---
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
A
L
T
G
-----
I
P
-
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
-
V
----
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
-
K
P
--
S
F
P
K
--
W
A
R
Q
D
F
S
------
K
V
V
P
P
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
---------------------------
72
PsiBlast_CBE
96.44
45%
-126
- C1 -
3QZG
2
CDK2_HUMAN
A:
[9-302]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
--
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------
H
---
T
---
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
A
L
T
G
-----
I
P
-
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
-
V
----
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
-
K
P
--
S
F
P
K
--
W
A
R
Q
D
F
S
------
K
V
V
P
P
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
---------------------------
62
PsiBlast_CBE
96.05
45%
-128
- C1 -
3R7E
2
CDK2_HUMAN
A:
[9-302]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
--
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------
H
---
T
---
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
A
L
T
G
-----
I
P
-
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
-
V
----
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
-
K
P
--
S
F
P
K
--
W
A
R
Q
D
F
S
------
K
V
V
P
P
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
---------------------------
36
PsiBlast_CBE
96.04
45%
-127
- C1 -
3RM7
2
CDK2_HUMAN
A:
[9-302]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
--
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------
H
---
T
---
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
A
L
T
G
-----
I
P
-
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
-
V
----
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
-
K
P
--
S
F
P
K
--
W
A
R
Q
D
F
S
------
K
V
V
P
P
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
---------------------------
66
PsiBlast_CBE
95.85
45%
-120
- C1 -
3R28
2
CDK2_HUMAN
A:
[9-302]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
--
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------
H
---
T
---
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
A
L
T
G
-----
I
P
-
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
-
V
----
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
-
K
P
--
S
F
P
K
--
W
A
R
Q
D
F
S
------
K
V
V
P
P
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
---------------------------
33
PsiBlast_CBE
95.72
45%
-120
- C1 -
3ROY
2
CDK2_HUMAN
A:
[9-302]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
--
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------
H
---
T
---
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
A
L
T
G
-----
I
P
-
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
-
V
----
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
-
K
P
--
S
F
P
K
--
W
A
R
Q
D
F
S
------
K
V
V
P
P
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
---------------------------
9
PsiBlast_PDB
95.72
45%
-125
- C1 -
3QQF
2
CDK2_HUMAN
A:
[9-302]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
--
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------
H
---
T
---
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
A
L
T
G
-----
I
P
-
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
-
V
----
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
-
K
P
--
S
F
P
K
--
W
A
R
Q
D
F
S
------
K
V
V
P
P
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
---------------------------
19
PsiBlast_PDB
95.70
45%
-128
- C1 -
3QX4
3
CDK2_HUMAN
A:
[9-302]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
--
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------
H
---
T
---
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
A
L
T
G
-----
I
P
-
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
-
V
----
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
-
K
P
--
S
F
P
K
--
W
A
R
Q
D
F
S
------
K
V
V
P
P
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
---------------------------
27
PsiBlast_CBE
95.64
45%
-126
- C1 -
3S00
1
CDK2_HUMAN
A:
[9-302]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
--
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------
H
---
T
---
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
A
L
T
G
-----
I
P
-
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
-
V
----
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
-
K
P
--
S
F
P
K
--
W
A
R
Q
D
F
S
------
K
V
V
P
P
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
---------------------------
14
PsiBlast_PDB
95.55
45%
-126
- C1 -
3QRT
3
CDK2_HUMAN
A:
[9-302]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
--
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------
H
---
T
---
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
A
L
T
G
-----
I
P
-
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
-
V
----
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
-
K
P
--
S
F
P
K
--
W
A
R
Q
D
F
S
------
K
V
V
P
P
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
---------------------------
67
PsiBlast_CBE
95.54
45%
-124
- C1 -
3R1Y
2
CDK2_HUMAN
A:
[9-302]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
--
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------
H
---
T
---
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
A
L
T
G
-----
I
P
-
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
-
V
----
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
-
K
P
--
S
F
P
K
--
W
A
R
Q
D
F
S
------
K
V
V
P
P
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
---------------------------
68
PsiBlast_CBE
95.47
45%
-120
- C1 -
3R1S
2
CDK2_HUMAN
A:
[9-302]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
--
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------
H
---
T
---
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
A
L
T
G
-----
I
P
-
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
-
V
----
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
-
K
P
--
S
F
P
K
--
W
A
R
Q
D
F
S
------
K
V
V
P
P
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
---------------------------
65
PsiBlast_CBE
95.47
45%
-121
- C1 -
3R6X
2
CDK2_HUMAN
A:
[9-302]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
--
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------
H
---
T
---
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
A
L
T
G
-----
I
P
-
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
-
V
----
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
-
K
P
--
S
F
P
K
--
W
A
R
Q
D
F
S
------
K
V
V
P
P
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
---------------------------
54
PsiBlast_CBE
95.36
45%
-129
- C1 -
3R8P
1
CDK2_HUMAN
A:
[9-302]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
--
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------
H
---
T
---
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
A
L
T
G
-----
I
P
-
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
-
V
----
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
-
K
P
--
S
F
P
K
--
W
A
R
Q
D
F
S
------
K
V
V
P
P
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
---------------------------
52
PsiBlast_CBE
95.35
45%
-126
- C1 -
3R8V
1
CDK2_HUMAN
A:
[9-302]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
--
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------
H
---
T
---
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
A
L
T
G
-----
I
P
-
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
-
V
----
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
-
K
P
--
S
F
P
K
--
W
A
R
Q
D
F
S
------
K
V
V
P
P
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
---------------------------
20
PsiBlast_PDB
95.32
45%
-123
- C1 -
3QXO
2
CDK2_HUMAN
A:
[9-302]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
--
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------
H
---
T
---
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
A
L
T
G
-----
I
P
-
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
-
V
----
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
-
K
P
--
S
F
P
K
--
W
A
R
Q
D
F
S
------
K
V
V
P
P
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
---------------------------
57
PsiBlast_CBE
95.27
45%
-125
- C1 -
3R83
2
CDK2_HUMAN
A:
[9-302]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
--
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------
H
---
T
---
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
A
L
T
G
-----
I
P
-
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
-
V
----
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
-
K
P
--
S
F
P
K
--
W
A
R
Q
D
F
S
------
K
V
V
P
P
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
---------------------------
30
PsiBlast_CBE
95.21
45%
-126
- C1 -
3RPV
2
CDK2_HUMAN
A:
[9-302]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
--
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------
H
---
T
---
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
A
L
T
G
-----
I
P
-
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
-
V
----
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
-
K
P
--
S
F
P
K
--
W
A
R
Q
D
F
S
------
K
V
V
P
P
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
---------------------------
58
PsiBlast_CBE
95.17
45%
-126
- C1 -
3R7Y
2
CDK2_HUMAN
A:
[9-302]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
--
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------
H
---
T
---
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
A
L
T
G
-----
I
P
-
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
-
V
----
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
-
K
P
--
S
F
P
K
--
W
A
R
Q
D
F
S
------
K
V
V
P
P
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
---------------------------
51
PsiBlast_CBE
95.14
45%
-132
- C1 -
3R8Z
1
CDK2_HUMAN
A:
[9-302]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
--
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------
H
---
T
---
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
A
L
T
G
-----
I
P
-
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
---------
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
-
K
P
--
S
F
P
K
--
W
A
R
Q
D
F
S
------
K
V
V
P
P
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
---------------------------
79
PsiBlast_CBE
95.13
45%
-123
- C1 -
3QTU
1
CDK2_HUMAN
A:
[9-302]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
--
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------
H
---
T
---
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
A
L
T
G
-----
I
P
-
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
-
V
----
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
-
K
P
--
S
F
P
K
--
W
A
R
Q
D
F
S
------
K
V
V
P
P
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
---------------------------
70
PsiBlast_CBE
95.09
45%
-122
- C1 -
3QZI
2
CDK2_HUMAN
A:
[9-302]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
--
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------
H
---
T
---
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
A
L
T
G
-----
I
P
-
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
-
V
----
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
-
K
P
--
S
F
P
K
--
W
A
R
Q
D
F
S
------
K
V
V
P
P
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
---------------------------
82
PsiBlast_CBE
95.08
45%
-123
- C1 -
3QTQ
2
CDK2_HUMAN
A:
[9-302]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
--
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------
H
---
T
---
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
A
L
T
G
-----
I
P
-
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
-
V
----
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
-
K
P
--
S
F
P
K
--
W
A
R
Q
D
F
S
------
K
V
V
P
P
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
---------------------------
13
PsiBlast_PDB
95.08
45%
-127
- C1 -
3QQL
1
CDK2_HUMAN
A:
[9-302]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
--
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------
H
---
T
---
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
A
L
T
G
-----
I
P
-
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
-
V
----
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
-
K
P
--
S
F
P
K
--
W
A
R
Q
D
F
S
------
K
V
V
P
P
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
---------------------------
11
PsiBlast_PDB
95.03
45%
-124
- C1 -
3QQH
4
CDK2_HUMAN
A:
[9-302]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
--
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------
H
---
T
---
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
A
L
T
G
-----
I
P
-
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
-
V
----
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
-
K
P
--
S
F
P
K
--
W
A
R
Q
D
F
S
------
K
V
V
P
P
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
---------------------------
17
PsiBlast_PDB
95.01
45%
-124
- C1 -
3QWK
5
CDK2_HUMAN
A:
[9-302]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
--
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------
H
---
T
---
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
A
L
T
G
-----
I
P
-
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
-
V
----
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
-
K
P
--
S
F
P
K
--
W
A
R
Q
D
F
S
------
K
V
V
P
P
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
---------------------------
74
PsiBlast_CBE
95.00
45%
-123
- C1 -
3QXP
2
CDK2_HUMAN
A:
[9-302]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
--
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------
H
---
T
---
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
A
L
T
G
-----
I
P
-
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
-
V
----
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
-
K
P
--
S
F
P
K
--
W
A
R
Q
D
F
S
------
K
V
V
P
P
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
---------------------------
1
PsiBlast_PDB
94.98
45%
-121
- C1 -
3PXF
7
CDK2_HUMAN
A:
[5-302]
-------------------------------
S
P
E
F
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
--
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------
H
---
T
---
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
A
L
T
G
-----
I
P
-
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
-
V
----
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
-
K
P
--
S
F
P
K
--
W
A
R
Q
D
F
S
------
K
V
V
P
P
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
---------------------------
53
PsiBlast_CBE
94.92
45%
-121
- C1 -
3R8U
1
CDK2_HUMAN
A:
[9-302]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
--
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------
H
---
T
---
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
A
L
T
G
-----
I
P
-
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
-
V
----
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
-
K
P
--
S
F
P
K
--
W
A
R
Q
D
F
S
------
K
V
V
P
P
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
---------------------------
8
PsiBlast_PDB
94.92
45%
-122
- C1 -
3QL8
2
CDK2_HUMAN
A:
[9-302]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
--
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------
H
---
T
---
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
A
L
T
G
-----
I
P
-
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
-
V
----
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
-
K
P
--
S
F
P
K
--
W
A
R
Q
D
F
S
------
K
V
V
P
P
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
---------------------------
4
PsiBlast_PDB
94.91
45%
-122
- C1 -
3PXY
1
CDK2_HUMAN
A:
[9-302]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
--
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------
H
---
T
---
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
A
L
T
G
-----
I
P
-
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
-
V
----
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
-
K
P
--
S
F
P
K
--
W
A
R
Q
D
F
S
------
K
V
V
P
P
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
---------------------------
23
PsiBlast_CBE
94.90
45%
-126
- C1 -
4EZ3
2
CDK2_HUMAN
A:
[9-302]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
--
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------
H
---
T
---
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
A
L
T
G
-----
I
P
-
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
-
V
----
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
-
K
P
--
S
F
P
K
--
W
A
R
Q
D
F
S
------
K
V
V
P
P
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
---------------------------
12
PsiBlast_PDB
94.87
45%
-120
- C1 -
3QQJ
2
CDK2_HUMAN
A:
[9-302]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
--
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------
H
---
T
---
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
A
L
T
G
-----
I
P
-
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
-
V
----
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
-
K
P
--
S
F
P
K
--
W
A
R
Q
D
F
S
------
K
V
V
P
P
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
---------------------------
32
PsiBlast_CBE
94.74
45%
-123
- C1 -
3RPO
2
CDK2_HUMAN
A:
[9-302]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
--
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------
H
---
T
---
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
A
L
T
G
-----
I
P
-
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
-
V
----
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
-
K
P
--
S
F
P
K
--
W
A
R
Q
D
F
S
------
K
V
V
P
P
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
---------------------------
40
PsiBlast_CBE
94.67
45%
-122
- C1 -
3RK7
2
CDK2_HUMAN
A:
[9-302]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
--
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------
H
---
T
---
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
A
L
T
G
-----
I
P
-
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
-
V
----
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
-
K
P
--
S
F
P
K
--
W
A
R
Q
D
F
S
------
K
V
V
P
P
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
---------------------------
75
PsiBlast_CBE
94.64
45%
-123
- C1 -
3QU0
5
CDK2_HUMAN
A:
[9-302]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
--
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------
H
---
T
---
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
A
L
T
G
-----
I
P
-
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
-
V
----
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
-
K
P
--
S
F
P
K
--
W
A
R
Q
D
F
S
------
K
V
V
P
P
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
---------------------------
2
PsiBlast_PDB
94.63
45%
-120
- C1 -
3PXQ
4
CDK2_HUMAN
A:
[5-302]
-------------------------------
S
P
E
F
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
--
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------
H
---
T
---
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
A
L
T
G
-----
I
P
-
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
-
V
----
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
-
K
P
--
S
F
P
K
--
W
A
R
Q
D
F
S
------
K
V
V
P
P
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
---------------------------
90
PsiBlast_CBE
94.61
45%
-123
- C1 -
4KD1
2
CDK2_HUMAN
A:
[1-294]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
--
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------
H
---
T
---
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
A
L
T
G
-----
I
P
-
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
-
V
----
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
-
K
P
--
S
F
P
K
--
W
A
R
Q
D
F
S
------
K
V
V
P
P
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
---------------------------
46
PsiBlast_CBE
94.61
45%
-127
- C1 -
3RAH
1
CDK2_HUMAN
A:
[9-302]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
--
K
L
T
G
E
V
V
A
L
K
K
I
R
--------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------
H
---
T
---
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
A
L
T
G
-----
I
P
-
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
-------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
-
K
P
--
S
F
P
K
--
W
A
R
Q
D
F
S
------
K
V
V
P
P
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
---------------------------
15
PsiBlast_PDB
94.61
45%
-126
- C1 -
3QRU
2
CDK2_HUMAN
A:
[9-302]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
--
K
L
T
G
E
V
V
A
L
K
K
I
R
L
---
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------
H
---
T
---
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
A
L
T
G
-----
I
P
-
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
-
V
----
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
-
K
P
--
S
F
P
K
--
W
A
R
Q
D
F
S
------
K
V
V
P
P
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
---------------------------
10
PsiBlast_PDB
94.59
45%
-121
- C1 -
3QQG
2
CDK2_HUMAN
A:
[9-302]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
--
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------
H
---
T
---
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
A
L
T
G
-----
I
P
-
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
-
V
----
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
-
K
P
--
S
F
P
K
--
W
A
R
Q
D
F
S
------
K
V
V
P
P
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
---------------------------
49
PsiBlast_CBE
94.56
45%
-127
- C1 -
3R9H
1
CDK2_HUMAN
A:
[9-302]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
--
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------
H
---
T
---
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
A
L
T
G
-----
I
P
-
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
-
V
----
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
-
K
P
--
S
F
P
K
--
W
A
R
Q
D
F
S
------
K
V
V
P
P
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
---------------------------
64
PsiBlast_CBE
94.53
45%
-124
- C1 -
3R71
2
CDK2_HUMAN
A:
[9-302]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
--
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------
H
---
T
---
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
A
L
T
G
-----
I
P
-
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
-
V
----
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
-
K
P
--
S
F
P
K
--
W
A
R
Q
D
F
S
------
K
V
V
P
P
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
---------------------------
63
PsiBlast_CBE
94.45
45%
-123
- C1 -
3R73
2
CDK2_HUMAN
A:
[9-302]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
--
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------
H
---
T
---
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
A
L
T
G
-----
I
P
-
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
-
V
----
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
-
K
P
--
S
F
P
K
--
W
A
R
Q
D
F
S
------
K
V
V
P
P
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
---------------------------
18
PsiBlast_PDB
94.43
45%
-123
- C1 -
3QX2
2
CDK2_HUMAN
A:
[9-302]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
--
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------
H
---
T
---
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
A
L
T
G
-----
I
P
-
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
-
V
----
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
-
K
P
--
S
F
P
K
--
W
A
R
Q
D
F
S
------
K
V
V
P
P
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
---------------------------
50
PsiBlast_CBE
94.40
45%
-121
- C1 -
3R9D
1
CDK2_HUMAN
A:
[9-302]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
--
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------
H
---
T
---
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
A
L
T
G
-----
I
P
-
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
-
V
----
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
-
K
P
--
S
F
P
K
--
W
A
R
Q
D
F
S
------
K
V
V
P
P
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
---------------------------
41
PsiBlast_CBE
94.39
45%
-124
- C1 -
3RK5
1
CDK2_HUMAN
A:
[9-302]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
--
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------
H
---
T
---
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
A
L
T
G
-----
I
P
-
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
-
V
----
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
-
K
P
--
S
F
P
K
--
W
A
R
Q
D
F
S
------
K
V
V
P
P
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
---------------------------
37
PsiBlast_CBE
94.37
45%
-120
- C1 -
3RM6
2
CDK2_HUMAN
A:
[9-302]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
-
G
V
V
Y
K
A
R
N
--
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------
H
---
T
---
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
A
L
T
G
-----
I
P
-
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
-
V
----
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
-
K
P
--
S
F
P
K
--
W
A
R
Q
D
F
S
------
K
V
V
P
P
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
---------------------------
21
PsiBlast_CBE
94.36
45%
-123
- C1 -
4GCJ
5
CDK2_HUMAN
A:
[3-302]
-----------------------------
L
G
S
P
E
F
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
--
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------
H
---
T
---
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
A
L
T
G
-----
I
P
-
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
-
V
----
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
-
K
P
--
S
F
P
K
--
W
A
R
Q
D
F
S
------
K
V
V
P
P
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
---------------------------
56
PsiBlast_CBE
94.26
45%
-128
- C1 -
3R8L
1
CDK2_HUMAN
A:
[9-302]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
--
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------
H
---
T
---
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
A
L
T
G
-----
I
P
-
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
-
V
----
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
-
K
P
--
S
F
P
K
--
W
A
R
Q
D
F
S
------
K
V
V
P
P
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
---------------------------
45
PsiBlast_CBE
94.22
45%
-121
- C1 -
3RAI
2
CDK2_HUMAN
A:
[9-302]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
--
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------
H
---
T
---
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
A
L
T
G
-----
I
P
-
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
-
V
----
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
-
K
P
--
S
F
P
K
--
W
A
R
Q
D
F
S
------
K
V
V
P
P
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
---------------------------
5
PsiBlast_PDB
94.22
45%
-122
- C1 -
3PXZ
3
CDK2_HUMAN
A:
[5-302]
-------------------------------
S
P
E
F
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
--
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------
H
---
T
---
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
A
L
T
G
-----
I
P
-
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
-
V
----
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
-
K
P
--
S
F
P
K
--
W
A
R
Q
D
F
S
------
K
V
V
P
P
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
---------------------------
77
PsiBlast_CBE
94.14
45%
-123
- C1 -
3QTX
1
CDK2_HUMAN
A:
[9-302]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
--
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------
H
---
T
---
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
A
L
T
G
-----
I
P
-
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
-
V
----
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
-
K
P
--
S
F
P
K
--
W
A
R
Q
D
F
S
------
K
V
V
P
P
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
---------------------------
59
PsiBlast_CBE
94.12
45%
-124
- C1 -
3R7V
2
CDK2_HUMAN
A:
[9-302]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
--
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------
H
---
T
---
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
A
L
T
G
-----
I
P
-
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
-
V
----
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
-
K
P
--
S
F
P
K
--
W
A
R
Q
D
F
S
------
K
V
V
P
P
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
---------------------------
16
PsiBlast_PDB
94.10
45%
-123
- C1 -
3QWJ
2
CDK2_HUMAN
A:
[9-302]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
--
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------
H
---
T
---
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
A
L
T
G
-----
I
P
-
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
-
V
----
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
-
K
P
--
S
F
P
K
--
W
A
R
Q
D
F
S
------
K
V
V
P
P
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
---------------------------
7
PsiBlast_PDB
94.10
45%
-114
- C1 -
3PY1
4
CDK2_HUMAN
A:
[5-302]
-------------------------------
S
P
E
F
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
--
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------
H
---
T
---
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
A
L
T
G
-----
I
P
-
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
-
V
----
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
-
K
P
--
S
F
P
K
--
W
A
R
Q
D
F
S
------
K
V
V
P
P
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
---------------------------
6
PsiBlast_PDB
94.06
45%
-119
- C1 -
3PY0
2
CDK2_HUMAN
A:
[9-302]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
--
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------
H
---
T
---
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
A
L
T
G
-----
I
P
-
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
-
V
----
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
-
K
P
--
S
F
P
K
--
W
A
R
Q
D
F
S
------
K
V
V
P
P
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
---------------------------
80
PsiBlast_CBE
93.90
45%
-127
- C1 -
3QTS
1
CDK2_HUMAN
A:
[9-302]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
--
K
L
T
G
E
V
V
A
L
K
K
I
R
--------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------
H
---
T
---
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
A
L
T
G
-----
I
P
-
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
-------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
-
K
P
--
S
F
P
K
--
W
A
R
Q
D
F
S
------
K
V
V
P
P
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
---------------------------
31
PsiBlast_CBE
93.86
45%
-128
- C1 -
3RPR
1
CDK2_HUMAN
A:
[9-302]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
--
K
L
T
G
E
V
V
A
L
K
K
I
R
--------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------
H
---
T
---
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
A
L
T
G
-----
I
P
-
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
-------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
-
K
P
--
S
F
P
K
--
W
A
R
Q
D
F
S
------
K
V
V
P
P
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
---------------------------
42
PsiBlast_CBE
93.82
45%
-127
- C1 -
3RJC
1
CDK2_HUMAN
A:
[9-302]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
--
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------
H
---
T
---
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
A
L
T
G
-----
I
P
-
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
-
V
----
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
-
K
P
--
S
F
P
K
--
W
A
R
Q
D
F
S
------
K
V
V
P
P
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
---------------------------
83
PsiBlast_CBE
93.79
45%
-122
- C1 -
3QQK
6
CDK2_HUMAN
A:
[9-302]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
--
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------
H
---
T
---
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
A
L
T
G
-----
I
P
-
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
-
V
----
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
-
K
P
--
S
F
P
K
--
W
A
R
Q
D
F
S
------
K
V
V
P
P
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
---------------------------
55
PsiBlast_CBE
93.74
45%
-125
- C1 -
3R8M
1
CDK2_HUMAN
A:
[9-302]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
--
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------
H
---
T
---
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
A
L
T
G
-----
I
P
-
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-------------
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
-
K
P
--
S
F
P
K
--
W
A
R
Q
D
F
S
------
K
V
V
P
P
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
---------------------------
73
PsiBlast_CBE
93.72
45%
-123
- C1 -
3QZF
1
CDK2_HUMAN
A:
[9-302]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
--
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------
H
---
T
---
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
A
L
T
G
-----
I
P
-
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
-
V
----
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
-
K
P
--
S
F
P
K
--
W
A
R
Q
D
F
S
------
K
V
V
P
P
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
---------------------------
39
PsiBlast_CBE
93.70
45%
-122
- C1 -
3RK9
1
CDK2_HUMAN
A:
[9-302]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
--
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------
H
---
T
---
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
A
L
T
G
-----
I
P
-
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
-
V
----
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
-
K
P
--
S
F
P
K
--
W
A
R
Q
D
F
S
------
K
V
V
P
P
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
---------------------------
60
PsiBlast_CBE
93.67
45%
-128
- C1 -
3R7U
2
CDK2_HUMAN
A:
[9-302]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
--
K
L
T
G
E
V
V
A
L
K
K
I
R
--------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------
H
---
T
---
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
A
L
T
G
-----
I
P
-
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
-------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
-
K
P
--
S
F
P
K
--
W
A
R
Q
D
F
S
------
K
V
V
P
P
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
---------------------------
76
PsiBlast_CBE
93.55
45%
-126
- C1 -
3QTZ
3
CDK2_HUMAN
A:
[9-302]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
--
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------
H
---
T
---
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
A
L
T
G
-----
I
P
-
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
-
V
----
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
-
K
P
--
S
F
P
K
--
W
A
R
Q
D
F
S
------
K
V
V
P
P
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
---------------------------
44
PsiBlast_CBE
93.55
45%
-133
- C1 -
3RAK
1
CDK2_HUMAN
A:
[9-302]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
--
K
L
T
G
E
V
V
A
L
K
K
I
R
--------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------
H
---
T
---
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
A
L
T
G
-----
I
P
-
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
E
G
A
I
K
L
A
D
F
G
L
A
------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
-
K
P
--
S
F
P
K
--
W
A
R
Q
D
F
S
------
K
V
V
P
P
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
---------------------------
81
PsiBlast_CBE
93.50
45%
-126
- C1 -
3QTR
1
CDK2_HUMAN
A:
[9-302]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
--
K
L
T
G
E
V
V
A
L
K
K
I
R
--------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------
H
---
T
---
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
A
L
T
G
-----
I
P
-
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
-------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
-
K
P
--
S
F
P
K
--
W
A
R
Q
D
F
S
------
K
V
V
P
P
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
---------------------------
48
PsiBlast_CBE
93.47
45%
-126
- C1 -
3R9N
1
CDK2_HUMAN
A:
[9-302]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
--
K
L
T
G
E
V
V
A
L
K
K
I
R
--------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------
H
---
T
---
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
A
L
T
G
-----
I
P
-
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
-------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
-
K
P
--
S
F
P
K
--
W
A
R
Q
D
F
S
------
K
V
V
P
P
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
---------------------------
38
PsiBlast_CBE
93.47
45%
-123
- C1 -
3RKB
2
CDK2_HUMAN
A:
[9-302]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
--
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------
H
---
T
---
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
A
L
T
G
-----
I
P
-
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
-
V
----
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
-
K
P
--
S
F
P
K
--
W
A
R
Q
D
F
S
------
K
V
V
P
P
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
---------------------------
89
PsiBlast_CBE
93.44
45%
-125
- C1 -
4LYN
1
CDK2_HUMAN
A:
[1-294]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
--
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------
H
---
T
---
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
A
L
T
G
-----
I
P
-
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
----------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
-
K
P
--
S
F
P
K
--
W
A
R
Q
D
F
S
------
K
V
V
P
P
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
---------------------------
61
PsiBlast_CBE
93.35
45%
-128
- C1 -
3R7I
2
CDK2_HUMAN
A:
[9-302]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
--
K
L
T
G
E
V
V
A
L
K
K
I
R
--------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------
H
---
T
---
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
A
L
T
G
-----
I
P
-
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
-------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
-
K
P
--
S
F
P
K
--
W
A
R
Q
D
F
S
------
K
V
V
P
P
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
---------------------------
24
PsiBlast_CBE
93.32
45%
-126
- C1 -
3SQQ
2
CDK2_HUMAN
A:
[9-302]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
--
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------
H
---
T
---
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
A
L
T
G
-----
I
P
-
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
-----------
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
-
K
P
--
S
F
P
K
--
W
A
R
Q
D
F
S
------
K
V
V
P
P
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
---------------------------
34
PsiBlast_CBE
93.23
45%
-124
- C1 -
3RNI
1
CDK2_HUMAN
A:
[9-302]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
--
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------
H
---
T
---
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
A
L
T
G
-----
I
P
-
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
-
V
----
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
-
K
P
--
S
F
P
K
--
W
A
R
Q
D
F
S
------
K
V
V
P
P
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
---------------------------
26
PsiBlast_CBE
93.12
45%
-123
- C1 -
3S0O
1
CDK2_HUMAN
A:
[9-302]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
--
K
L
T
G
E
V
V
A
L
K
K
I
R
L
---
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------
H
---
T
---
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
A
L
T
G
-----
I
P
-
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
E
G
A
I
K
L
A
D
F
--
A
R
A
F
G
V
P
-
V
----
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
-
K
P
--
S
F
P
K
--
W
A
R
Q
D
F
S
------
K
V
V
P
P
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
---------------------------
85
PsiBlast_CBE
92.86
45%
-131
- C1 -
3EZR
2
CDK2_HUMAN
A:
[3-296]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
--
K
L
T
G
E
V
V
A
L
K
K
I
R
-------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------
H
---
T
---
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
A
L
T
G
-----
I
P
-
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
E
G
A
I
K
L
A
D
F
-----------------------
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
-
K
P
--
S
F
P
K
--
W
A
R
Q
D
F
S
------
K
V
V
P
P
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
---------------------------
29
PsiBlast_CBE
92.75
45%
-130
- C1 -
3RPY
1
CDK2_HUMAN
A:
[9-302]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
--
K
L
T
G
E
V
V
A
L
K
K
I
R
--------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------
H
---
T
---
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
A
L
T
G
-----
I
P
-
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
E
G
A
I
K
L
A
D
F
G
L
A
------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
-
K
P
--
S
F
P
K
--
W
A
R
Q
D
F
S
------
K
V
V
P
P
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
---------------------------
35
PsiBlast_CBE
92.57
45%
-129
- C1 -
3RMF
1
CDK2_HUMAN
A:
[9-302]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
--
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------
H
---
T
---
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
A
L
T
G
-----
I
P
-
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
E
G
A
I
K
L
A
D
F
G
L
A
------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
-
K
P
--
S
F
P
K
--
W
A
R
Q
D
F
S
------
K
V
V
P
P
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
---------------------------
84
PsiBlast_CBE
92.54
45%
-129
- C1 -
3EZV
1
CDK2_HUMAN
A:
[3-296]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
--
K
L
T
G
E
V
V
A
L
K
K
I
R
-------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------
H
---
T
---
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
A
L
T
G
-----
I
P
-
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
E
G
A
I
K
L
A
D
F
G
L
-------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
-
K
P
--
S
F
P
K
--
W
A
R
Q
D
F
S
------
K
V
V
P
P
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
---------------------------
47
PsiBlast_CBE
92.25
45%
-127
- C1 -
3R9O
1
CDK2_HUMAN
A:
[9-302]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
--
K
L
T
G
E
V
V
A
L
K
K
I
R
--------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------
H
---
T
---
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
A
L
T
G
-----
I
P
-
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
-------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
-
K
P
--
S
F
P
K
--
W
A
R
Q
D
F
S
------
K
V
V
P
P
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
---------------------------
78
PsiBlast_CBE
92.11
45%
-120
- C1 -
3QTW
6
CDK2_HUMAN
A:
[9-302]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
--
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------
H
---
T
---
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
A
L
T
G
-----
I
P
-
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
-
V
----
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
-
K
P
--
S
F
P
K
--
W
A
R
Q
D
F
S
------
K
V
V
P
P
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
---------------------------
86
PsiBlast_CBE
92.04
45%
-129
- C1 -
1OIT
1
CDK2_HUMAN
A:
[3-294]
-------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
--
K
L
-
G
E
V
V
A
L
K
K
I
-----------
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------
H
---
T
---
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
A
L
T
G
-----
I
P
-
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
S
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
----------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
-
K
P
--
S
F
P
K
--
W
A
R
Q
D
F
S
------
K
V
V
P
P
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
---------------------------
25
PsiBlast_CBE
91.89
45%
-129
- C1 -
3S1H
1
CDK2_HUMAN
A:
[9-302]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
--
K
L
T
G
E
V
V
A
L
K
K
I
R
--------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------
H
---
T
---
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
A
L
T
G
-----
I
P
-
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
E
G
A
I
K
L
A
D
F
G
L
A
------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
-
K
P
--
S
F
P
K
--
W
A
R
Q
D
F
S
------
K
V
V
P
P
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
---------------------------
88
PsiBlast_CBE
91.69
45%
-127
- C1 -
5A14
2
?
A:
[2-295]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
--
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
--
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------
H
---
T
---
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
A
L
T
G
-----
I
P
-
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
---------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
-
K
P
--
S
F
P
K
--
W
A
R
Q
D
F
S
------
K
V
V
P
P
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
-----------------------------
92
PsiBlast_CBE
91.13
45%
-122
- C1 -
4FX3
2
CDK2_HUMAN
A:
[1-294]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
--
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------
H
---
T
---
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
A
L
T
G
-----
I
P
-
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
-
V
----
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
-
K
P
--
S
F
P
K
--
W
A
R
Q
D
F
S
------
K
V
V
P
P
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
---------------------------
43
PsiBlast_CBE
91.09
45%
-130
- C1 -
3RAL
1
CDK2_HUMAN
A:
[9-302]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
--
K
L
T
G
E
V
V
A
L
K
K
I
R
--------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------
H
---
T
---
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
A
L
T
G
-----
I
P
-
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
E
G
A
I
K
L
A
D
F
G
L
A
------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
-
K
P
--
S
F
P
K
--
W
A
R
Q
D
F
S
------
K
V
V
P
P
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
---------------------------
22
PsiBlast_CBE
90.94
45%
-119
- C1 -
4EZ7
7
CDK2_HUMAN
A:
[5-302]
-------------------------------
S
P
E
F
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
--
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------
H
---
T
---
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
A
L
T
G
-----
I
P
-
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
-
V
----
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
-
K
P
--
S
F
P
K
--
W
A
R
Q
D
F
S
------
K
V
V
P
P
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
---------------------------
28
PsiBlast_CBE
90.71
45%
-127
- C1 -
3RZB
1
CDK2_HUMAN
A:
[9-302]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
--
K
L
T
G
E
V
V
A
L
K
K
I
R
--------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------
H
---
T
---
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
A
L
T
G
-----
I
P
-
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
-------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
-
K
P
--
S
F
P
K
--
W
A
R
Q
D
F
S
------
K
V
V
P
P
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
---------------------------
91
PsiBlast_CBE
89.85
45%
-119
- C1 -
4FX3
1
CDK2_HUMAN
C:
[1-294]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
--
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------
H
---
T
---
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
-----
I
P
-
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
-
V
----
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
-
K
P
--
S
F
P
K
--
W
A
R
Q
D
F
S
------
K
V
V
P
P
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
R
L
---------------------------
111
HHSearch
89.29
43%
-114
- C1 -
1UA2
1
CDK7_HUMAN
A:
[13-308]
---------------------------------------
E
K
L
D
F
L
G
E
G
Q
F
A
T
V
Y
K
A
R
D
--
K
N
T
N
Q
I
V
A
I
K
K
I
---------
N
R
T
A
L
R
E
I
K
L
L
Q
E
L
S
H
P
N
I
I
G
L
L
D
A
F
G
H
----
K
----------
S
N
-
I
S
L
V
F
D
F
M
E
T
D
L
-----
E
V
I
I
K
D
-----
N
S
-
L
V
L
T
P
S
H
I
K
A
Y
M
L
M
T
L
Q
G
L
E
Y
L
H
Q
H
W
I
L
H
R
D
L
K
P
N
N
L
L
L
----
D
E
N
G
V
L
K
L
A
D
F
G
L
A
K
S
F
G
S
P
-
N
----
R
A
Y
T
H
Q
V
V
T
R
W
Y
R
A
P
E
L
L
F
G
A
R
M
Y
G
V
G
V
D
M
W
A
V
G
C
I
L
A
E
L
L
L
-----------
R
V
P
F
L
P
G
D
S
-------
D
----
L
D
Q
L
T
R
I
F
E
T
L
G
T
P
T
E
E
Q
W
P
D
M
C
S
L
P
D
Y
--
V
--
T
F
K
S
--
F
P
G
I
P
L
H
------
H
I
F
S
A
A
G
D
D
L
L
D
L
I
Q
G
L
F
L
F
N
P
C
A
R
I
T
A
T
Q
A
L
K
M
K
Y
F
S
N
--
R
P
G
P
T
P
G
C
Q
L
P
R
P
N
---------------------
123
HHSearch
88.93
44%
-125
- C1 -
4AU8
2
CDK5_HUMAN
A:
[6-293]
------------------------------------
Q
K
Y
E
K
L
E
K
I
G
E
G
T
Y
G
T
V
F
K
A
K
N
--
R
E
T
H
E
I
V
A
L
K
R
V
---------
P
S
S
A
L
R
E
I
C
L
L
K
E
L
K
H
K
N
I
V
R
L
H
D
V
L
H
-----------------
K
-
L
T
L
V
F
E
F
C
D
Q
D
L
-----
K
K
Y
F
D
S
-----
C
N
-
G
D
L
D
P
E
I
V
K
S
F
L
F
Q
L
L
K
G
L
G
F
C
H
S
R
N
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
R
N
G
E
L
K
L
A
D
F
G
L
A
R
A
F
G
I
P
-
V
----
R
--
S
A
E
V
V
T
L
W
Y
R
P
P
D
V
L
F
G
A
K
L
Y
S
T
S
I
D
M
W
S
A
G
C
I
F
A
E
L
A
N
A
----------
G
R
P
L
F
P
G
N
D
-------
V
----
D
D
Q
L
K
R
I
F
R
L
L
G
T
P
T
E
E
Q
W
P
S
M
T
K
L
P
D
Y
K
P
Y
--
P
M
Y
---
P
A
T
T
S
L
V
------
N
V
V
P
K
L
N
A
T
G
R
D
L
L
Q
N
L
L
K
C
N
P
V
Q
R
I
S
A
E
E
A
L
Q
H
P
Y
F
S
D
--
F
----------------------------------
116
HHSearch
88.50
44%
-116
- C1 -
4NST
3
CDK12_HUMAN
A:
[10-313]
---------------------------------
R
C
V
D
K
F
D
I
I
G
I
I
G
E
G
T
Y
G
Q
V
Y
K
A
K
D
--
K
D
T
G
E
L
V
A
L
K
K
V
R
L
D
N
E
K
E
G
F
P
I
T
A
I
R
E
I
K
I
L
R
Q
L
I
H
R
S
V
V
N
M
K
E
I
V
T
D
----
K
QD--------
G
A
-
F
Y
L
V
F
E
Y
M
D
H
D
L
-----
M
G
L
L
E
S
-----
G
L
-
V
H
F
S
E
D
H
I
K
S
F
M
K
Q
L
M
E
G
L
E
Y
C
H
K
K
N
F
L
H
R
D
I
K
C
S
N
I
L
L
----
N
N
S
G
Q
I
K
L
A
D
F
G
L
A
R
L
Y
N
S
E
E
S
----
R
P
Y
T
N
K
V
I
T
L
W
Y
R
P
P
E
L
L
L
G
E
E
R
Y
T
P
A
I
D
V
W
S
C
G
C
I
L
G
E
L
F
T
-----------
K
K
P
I
F
Q
A
N
L
-------
E
----
L
A
Q
L
E
L
I
S
R
L
C
G
S
P
C
P
A
V
W
P
D
V
I
K
L
P
Y
F
N
T
M
--
K
P
K
K
--
Q
Y
R
R
R
L
R
------
E
E
F
S
F
I
P
S
A
A
L
D
L
L
D
H
M
L
T
L
D
P
S
K
R
C
T
A
E
Q
T
L
Q
S
D
F
L
K
D
--
V
E
L
S
K
M
A
P
P
D
L
P
H
W
Q
D
C
H
E
L
W
S
K
K
-----------
87
PsiBlast_CBE
87.97
45%
-130
- C1 -
5D1J
1
?
A:
[1-294]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
--
Y
G
V
V
Y
K
A
R
N
--
K
L
T
G
E
V
V
A
L
K
K
I
R
--------------
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------
H
---
T
---
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
A
L
T
G
-----
I
P
-
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
E
G
A
I
K
L
A
D
F
----------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
-
K
P
--
S
F
P
K
--
W
A
R
Q
D
F
S
------
K
V
V
P
P
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
---------------------------
113
HHSearch
84.06
37%
-110
- C1 -
3N9X
2
?
A:
[26-371]
------------------------------------
D
N
Y
I
I
K
H
L
I
G
R
G
S
Y
G
Y
V
Y
L
A
Y
D
--
K
N
T
E
K
N
V
A
I
K
K
V
N
R
M
F
E
D
L
I
D
C
K
R
I
L
R
E
I
T
I
L
N
R
L
K
S
D
Y
I
I
R
L
Y
D
L
I
I
P
----
D
--
D
---
L
LKF
D
E
-
L
Y
I
V
L
E
I
A
D
S
D
L
-----
K
K
L
F
K
T
------
P
-
I
F
L
T
E
E
H
I
K
T
I
L
Y
N
L
L
L
G
E
N
F
I
H
E
S
G
I
I
H
R
D
L
K
P
A
N
C
L
L
----
N
Q
D
C
S
V
K
V
C
D
F
G
L
A
R
T
I
--------------
H
V
V
T
R
W
Y
R
A
P
E
L
I
L
L
Q
E
N
Y
T
K
S
I
D
I
W
S
T
G
C
I
F
A
E
L
L
N
MLQSHINDPTN
R
F
P
L
F
P
G
S
S
CFPH
E
K
S
N
----
R
D
Q
L
N
I
I
F
N
I
I
G
T
P
T
E
D
D
L
K
N
I
N
K
P
E
V
I
K
Y
I
K
-
L
F
P
H
--
R
K
P
I
N
L
K
------
Q
K
Y
P
S
I
S
D
D
G
I
N
L
L
E
S
M
L
K
F
N
P
N
K
R
I
T
I
D
Q
A
L
D
H
P
Y
L
K
D
--
V
R
K
K
K
L
E
T
K
K
I
I
L
P
F
D
D
W
M
V
L
S
E
T
Q
L
R
Y
I
F
L
K
E
V
Q
119
HHSearch
84.01
39%
-119
- C1 -
4F6U
10
CDK8_HUMAN
A:
[27-347]
------------------------------------------
C
K
V
G
R
G
T
Y
G
H
V
Y
K
A
K
R
KD
G
K
D
D
K
D
Y
A
L
K
Q
I
E
----
G
T
G
I
S
M
S
A
C
R
E
I
A
L
L
R
E
L
K
H
P
N
V
I
S
L
Q
K
V
F
L
S
----
H
--
A
---
D
---
R
K
-
V
W
L
L
F
D
Y
A
E
H
D
L
-----
W
H
I
I
K
F
H
R
A
S
K---
V
Q
L
P
R
G
M
V
K
S
L
L
Y
Q
I
L
D
G
I
H
Y
L
H
A
N
W
V
L
H
R
D
L
K
P
A
N
I
L
V
M
G
EG
P
E
R
G
R
V
K
I
A
D
M
G
F
-------------------
V
V
T
F
W
Y
R
A
P
E
L
L
L
G
A
R
H
Y
T
K
A
I
D
I
W
A
I
G
C
I
F
A
E
L
L
T
-----------
S
E
P
I
F
H
C
R
Q
-------
E
NPYH
H
D
Q
L
D
R
I
F
N
V
M
G
F
P
A
D
K
D
W
E
D
I
K
K
M
P
E
H
S
T
L
M
K
D
F
R
R
--
N
T
Y
T
N
C
S
L
I
K
Y
M
E
K
H
K
V
K
P
D
S
K
A
F
H
L
L
Q
K
L
L
T
M
D
P
I
K
R
I
T
S
E
Q
A
M
Q
D
P
Y
F
L
E
--
D
P
L
P
T
S
D
V
F
A
G
C
Q
I
P
Y
P
K
R
E
F
L
-------------
129
HHSearch
81.30
34%
-116
- C1 -
2B9H
1
FUS3_YEAST
A:
[11-317]
------------------------------------
S
D
F
Q
L
K
S
L
L
G
E
G
A
Y
G
V
V
C
S
A
T
H
--
K
P
T
G
E
I
V
A
I
K
K
I
E
P
F
D
-
K
P
L
F
A
L
R
T
L
R
E
I
K
I
L
K
H
F
K
H
E
N
I
I
T
I
F
N
I
Q
R
P
----
D
--
S
FEN
F
---
N
E
-
V
Y
I
I
Q
E
L
M
Q
T
D
L
-----
H
R
V
I
S
T
--------
Q
M
L
S
D
D
H
I
Q
Y
F
I
Y
Q
T
L
R
A
V
K
V
L
H
G
S
N
V
I
H
R
D
L
K
P
S
N
L
L
I
----
N
S
N
C
D
L
K
V
C
D
F
G
L
A
R
I
I
D
-----------
V
E
F
V
A
T
R
W
Y
R
A
P
E
V
M
L
T
S
A
K
Y
S
R
A
M
D
V
W
S
C
G
C
I
L
A
E
L
F
L
-----------
R
R
P
I
F
P
G
R
D
-------
Y
----
R
H
Q
L
L
L
I
F
G
I
I
G
T
P
H
S
D
N
D
L
R
C
I
E
S
P
R
A
R
E
Y
I
K
S
L
P
M
--
Y
P
A
A
P
L
E
------
K
M
F
P
R
V
N
P
K
G
I
D
L
L
Q
R
M
L
V
F
D
P
A
K
R
I
T
A
K
E
A
L
E
H
P
Y
L
Q
T
--
Y
H
D
P
N
D
E
P
E
G
E
P
I
P
P
S
F
F
E
F
D
H
Y
K
E
A
L
T
T
K
D
L
K
K
L
134
HHSearch
78.30
36%
-123
- C1 -
4BGQ
3
CDKL5_HUMAN
A:
[12-303]
------------------------------------
N
K
F
E
I
L
G
V
V
G
E
G
A
Y
G
V
V
L
K
C
R
H
--
K
E
T
H
E
I
V
A
I
K
K
F
K
-------
V
K
E
T
T
L
R
E
L
K
M
L
R
T
L
K
Q
E
N
I
V
E
L
K
E
A
F
R
R
----
R
----------
G
K
-
L
Y
L
V
F
E
Y
V
E
K
N
M
-----
L
E
L
L
E
E
-----
M
P
-
N
G
V
P
P
E
K
V
K
S
Y
I
Y
Q
L
I
K
A
I
H
W
C
H
K
N
D
I
V
H
R
D
I
K
P
E
N
L
L
I
----
S
H
N
D
V
L
K
L
C
D
F
G
F
A
R
N
L
S
E
---------------
T
R
W
Y
R
S
P
E
L
L
L
G
A
-
P
Y
G
K
S
V
D
M
W
S
V
G
C
I
L
G
E
L
S
D
-----------
G
Q
P
L
F
P
G
E
S
-------
E
----
I
D
Q
L
F
T
I
Q
K
V
L
G
P
L
P
S
E
Q
M
K
L
F
Y
S
N
P
R
F
H
G
L
--
R
F
P
A
V
N
H
P
Q
S
L
E
R
------
R
Y
L
G
I
L
N
S
V
L
L
D
L
M
K
N
L
L
K
L
D
P
A
D
R
Y
L
T
E
Q
C
L
N
H
P
T
F
Q
T
--
Q
R
L
--------------------------------
118
HHSearch
77.12
35%
-111
- C1 -
4IC7
1
MK07_HUMAN
A:
[55-355]
------------------------------------
D
E
Y
E
I
I
E
T
I
G
N
G
A
Y
G
V
V
S
S
A
R
R
--
R
L
T
G
Q
Q
V
A
I
K
K
I
P
N
A
F
D
V
V
T
N
A
K
R
T
L
R
E
L
K
I
L
K
H
F
K
H
D
N
I
I
A
I
K
D
I
L
R
P
TVPY
G
--
E
---
F
---
K
S
-
V
Y
V
V
L
D
L
M
E
S
D
L
-----
H
Q
I
I
H
S
------
S
-
Q
P
L
T
L
E
H
V
R
Y
F
L
Y
Q
L
L
R
G
L
K
Y
M
H
S
A
Q
V
I
H
R
D
L
K
P
S
N
L
L
V
----
N
E
N
C
E
L
K
I
G
D
F
G
M
A
R
G
L
C
T
S
-
P
AEHQ
Y
F
M
T
E
Y
V
A
T
R
W
Y
R
A
P
E
L
M
L
S
L
H
E
Y
T
Q
A
I
D
L
W
S
V
G
C
I
F
G
E
M
L
A
-----------
R
R
Q
L
F
P
G
K
N
-------
Y
----
V
H
Q
L
Q
L
I
M
M
V
L
G
T
P
S
P
A
V
I
Q
A
V
G
A
E
R
V
-
R
A
Y
IQ
S
L
P
P
--
R
Q
P
V
P
W
E
------
T
V
Y
P
G
A
D
R
Q
A
L
S
L
L
G
R
M
L
R
F
E
P
S
A
R
I
S
A
A
A
A
L
R
H
P
F
L
A
K
--
Y
H
D
P
D
D
E
P
D
C
A
P
P
F
D
F
A
F
D
R
E
A
L
T
R
E
R
I
K
E
A
I
V
A
E
128
HHSearch
76.31
35%
-116
- C1 -
2FST
3
MK14_HUMAN
X:
[30-330]
-------------------------------------
R
Y
Q
N
L
S
P
V
G
----
G
S
V
C
A
A
F
D
--
T
K
T
G
L
R
V
A
V
K
K
L
S
R
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
P
----
A
R-
S
---
L
EEF
N
D
-
V
Y
L
V
T
H
L
M
G
A
D
L
-----
N
-------------
Q
K
L
T
D
D
H
V
Q
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
----
N
E
D
C
E
L
K
I
L
D
-----------------------
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
-----------
G
R
T
L
F
P
G
T
D
-------
H
----
I
D
Q
L
K
L
I
L
R
L
V
G
T
P
G
A
E
L
L
K
K
I
S
S
E
S
A
R
-
N
Y
IQ
S
L
T
Q
--
M
P
K
M
N
F
A
------
N
V
F
I
G
A
N
P
L
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
--
Y
H
D
P
D
D
E
P
V
A
D
P
Y
D
Q
S
L
E
S
R
D
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
94
PsiBlast_CBE
59.81
45%
-14
- C1 -
4FKV
2
CDK2_HUMAN
A:
[4-295]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
--
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-----
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------
H
---
T
---
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
A
L
T
G
-----
I
P
-
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
----------------
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
-
K
P
--
S
F
P
K
--
W
A
R
Q
D
F
S
------
K
V
V
P
P
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
---------------------------
96
PsiBlast_CBE
58.13
45%
-16
- C1 -
4FKQ
2
CDK2_HUMAN
A:
[4-295]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
--
K
L
T
G
E
V
V
A
L
K
K
I
R
L
------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------
H
---
T
---
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
A
L
T
G
-----
I
P
-
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
--------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
-
K
P
--
S
F
P
K
--
W
A
R
Q
D
F
S
------
K
V
V
P
P
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
---------------------------
98
PsiBlast_CBE
57.65
45%
-12
- C1 -
4FKO
1
CDK2_HUMAN
A:
[4-295]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
--
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------
H
---
T
---
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
A
L
T
G
-----
I
P
-
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
-
V
----
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
-
K
P
--
S
F
P
K
--
W
A
R
Q
D
F
S
------
K
V
V
P
P
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
---------------------------
95
PsiBlast_CBE
57.22
45%
-13
- C1 -
4FKR
2
CDK2_HUMAN
A:
[4-295]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
--
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------
H
---
T
---
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
A
L
T
G
-----
I
P
-
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
--------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
-
K
P
--
S
F
P
K
--
W
A
R
Q
D
F
S
------
K
V
V
P
P
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
---------------------------
93
PsiBlast_CBE
57.05
45%
-11
- C1 -
4FKW
2
CDK2_HUMAN
A:
[4-295]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
--
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-----
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------
H
---
T
---
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
A
L
T
G
-----
I
P
-
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
E
G
A
I
K
L
A
D
F
G
L
A
------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
-
K
P
--
S
F
P
K
--
W
A
R
Q
D
F
S
------
K
V
V
P
P
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
---------------------------
100
PsiBlast_CBE
56.58
45%
-15
- C1 -
4FKJ
1
CDK2_HUMAN
A:
[4-295]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
--
K
L
T
G
E
V
V
A
L
K
K
I
---------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------
H
---
T
---
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
A
L
T
G
-----
I
P
-
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
----------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
-
K
P
--
S
F
P
K
--
W
A
R
Q
D
F
S
------
K
V
V
P
P
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
---------------------------
121
HHSearch
56.24
44%
-4
* C1 *
4EK4
1
CDK2_HUMAN
A:
[4-293]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
--
K
L
T
G
E
V
V
A
L
K
K
I
---------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
----
E
----------
N
K
-
L
Y
L
V
F
E
F
L
H
Q
D
L
-----
K
K
F
M
D
A
-----
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
-
V
----
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
-
P
--
S
F
P
K
--
W
A
R
Q
D
F
S
------
K
V
V
P
P
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
--
V
T
K
P
V
P
H
L
---------------------------