@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : CDK14_HUMAN: (2015-10-04 )
MCDLIEPQPAEKIGKMKKLRRTLSESFSRIALKKDDTTFDEICVTKMSTRNCQGMDSVIKPLDTIPEDKKVRVQRTQSTFDPFEKPANQVKRVHSENNACINFKTSSTGKESPKVRRHSSPSSPTSPKFGKADSYEKLEKLGEGSYATVYKGKSKVNGKLVALKVIRLQEEEGTPFTAIREASLLKGLKHANIVLLHDIIHTKETLTLVFEYVHTDLCQYMDKHPGGLHPDNVKLFLFQLLRGLSYIHQRYILHRDLKPQNLLISDTGELKLADFGLARAKSVPSHTYSNEVVTLWYRPPDVLLGSTEYSTCLDMWGVGCIFVEMIQGVAAFPGMKDIQDQLERIFLVLGTPNEDTWPGVHSLPHFKPERFTLYSSKNLRQAWNKLSYVNHAEDLASKLLQCSPKNRLSAQAALSHEYFSDLPPRLWELTDMSSIFTVPNVRLQPEAGESMRAFGKNNSYGKSLSNSKH
Atome Classification :
(99 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130-........140.......150...--....160.......-170........180.......190.......200.-----.------.-......210.......220---.---.-----.-....230.......240.......250.......260..----.-....270.......280.-......290.......300.......310.......320.....-..330......----.340.......350.......360......--.370---...-.-....380..---..---.--..390.......400.......410.......420.......430.......440.......450.......460.......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MCDLIEP
Q
P
A
E
K
I
G
K
M
K
K
L
R
R
T
L
S
E
S
F
S
R
IALKKDDT
T
F
D
E
I
C
V
T
KMSTRNCQ
G
M
D
S
V
I
K
P
L
DTIPEDK
K
V
R
V
Q
RTQSTFD
P
F
E
K
P
A
N
Q
V
K
R
V
HSEN
N
A
C
I
N
F
K
TSSTGKESPKVRRHSSPSSPTSPKFGK--AD
S
Y
E
K
L
E
K
LGEG
S
Y
A
T
V
YKGKSK--VN
G
K
L
V
A
L
K
V
I
R
L
Q-EE-EGTP
F
T
A
I
R
E
A
S
L
L
K
GLKHA
N
I
V
L
L
H
D
I
I--H-----T------
K
-
E
T
L
T
L
V
F
E
Y
V
H
T
D
L
C
Q
Y
M
D---K---H-----P-GGLHP
D
N
V
K
L
F
L
F
Q
L
L
R
G
L
S
Y
I
H
Q
R
Y
I
L
HRDLKPQ
N
L
L
I----S-DTG
E
L
K
L
ADFGL
A
R
A
KSV-PSHTYSN
E
V
V
T
L
W
YR
P
P
D
V
L
LGST
E
Y
S
T
C
L
D
M
W
G
V
G
C
I
F
V
E
M
I
Q
-
G
V
AAFP
G
M
K
D
I
----
Q
D
Q
L
E
R
I
F
L
V
L
GTPNEDTWPGVHSLPHFKP--E
R
F
----
T
L
Y-S-SK
N
L
R
Q
A
W
N
---
K
L---S--YV
N
H
A
E
D
L
A
S
K
L
L
QCSPKNR
L
S
A
Q
A
A
L
S
H
E
Y
F
SDL
P
P
R
L
W
E
LTDMS
S
I
F
TVPN
V
R
LQPEAG
E
S
M
R
A
FGKNNSYGKSLSNSKH
7
PsiBlast_PDB
86.80
52%
-110
- C1 -
3NIZ
1
?
A:
[18-311]
---------------------------------------------------------------------------------------------------------------------------------
G
L
--
M
E
K
Y
Q
K
L
E
K
V
G
E
G
T
Y
G
V
V
Y
K
A
K
D
S
---
Q
G
R
I
V
A
L
K
R
I
R
-------
G
I
P
S
T
A
I
R
E
I
S
L
L
K
E
L
H
H
P
N
I
V
S
L
I
D
V
I
--
H
-----
S
------
E
-
R
C
L
T
L
V
F
E
F
M
E
K
D
L
K
K
V
L
D
---
E
---
N
-----
K
-
T
G
L
Q
D
S
Q
I
K
I
Y
L
Y
Q
L
L
R
G
V
A
H
C
H
Q
H
R
I
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
-
S
D
G
A
L
K
L
A
D
F
G
L
A
R
A
F
G
I
-
P
V
R
---
H
E
V
V
T
L
W
Y
R
A
P
D
V
L
M
G
S
K
K
Y
S
T
S
V
D
I
W
S
I
G
C
I
F
A
E
M
I
T
-
G
K
P
L
F
P
G
V
T
D
-----
D
D
Q
L
P
K
I
F
S
I
L
G
T
P
N
P
R
E
W
P
Q
V
Q
E
L
P
L
W
K
Q
--
R
T
F
----
Q
V
F
-
E
-
K
K
----
P
W
S
---
S
I
I
P-
G
--
F
C
Q
E
G
I
D
L
L
S
N
M
L
C
F
D
P
N
K
R
I
S
A
R
D
A
M
N
H
P
Y
F
K
D
L
D
P
Q
I
-------------------------------------------
20
PsiBlast_PDB
86.55
52%
-106
- C1 -
1V0P
1
CDC2H_PLAFK
A:
[2-286]
--------------------------------------------------------------------------------------------------------------------------------------
E
K
Y
H
G
L
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
Q
N
N
--
Y
-
G
E
T
F
A
L
K
K
I
R
L
E
K
E
D
-
E
G
I
P
S
T
T
I
R
E
I
S
I
L
K
E
L
K
H
S
N
I
V
K
L
Y
D
V
I
--
H
-----
T
------
K
-
K
R
L
V
L
V
F
E
H
L
D
Q
D
L
K
K
L
L
D
---
V
---
C
-----
E
-
G
G
L
E
S
V
T
A
K
S
F
L
L
Q
L
L
N
G
I
A
Y
C
H
D
R
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
-
R
E
G
E
L
K
I
A
D
F
G
L
A
R
A
F
G
----------
I
V
T
L
W
Y
R
A
P
D
V
L
M
G
S
K
K
Y
S
T
T
I
D
I
W
S
V
G
C
I
F
A
E
M
V
N
-
G
T
P
L
F
P
G
V
S
E
-----
A
D
Q
L
M
R
I
F
R
I
L
G
T
P
N
S
K
N
W
P
N
V
T
E
L
P
K
Y
D
P
---
N
F
----
T
V
Y
-
E
-
P
L
P
W
E
S
F
L
K
---
G
L
---
D
----
E
S
G
I
D
L
L
S
K
M
L
K
L
D
P
N
Q
R
I
T
A
K
Q
A
L
E
H
A
Y
F
K
E
------------------------------------------------
121
HHSearch
86.33
51%
-105
- C1 -
3NIZ
1
?
A:
[15-311]
------------------------------------------------------------------------------------------------------------------------------
Y
F
Q
G
L
--
M
E
K
Y
Q
K
L
E
K
V
G
E
G
T
Y
G
V
V
Y
K
A
K
D
---
S
Q
G
R
I
V
A
L
K
R
I
R
-------
G
I
P
S
T
A
I
R
E
I
S
L
L
K
E
L
H
H
P
N
I
V
S
L
I
D
V
I
--
H
-----
S
------
E
-
R
C
L
T
L
V
F
E
F
M
E
K
D
L
K
K
V
L
D
---
E
---
N
-----
K
-
T
G
L
Q
D
S
Q
I
K
I
Y
L
Y
Q
L
L
R
G
V
A
H
C
H
Q
H
R
I
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
-
S
D
G
A
L
K
L
A
D
F
G
L
A
R
A
F
G
I
-
P
V
R
---
H
E
V
V
T
L
W
Y
R
A
P
D
V
L
M
G
S
K
K
Y
S
T
S
V
D
I
W
S
I
G
C
I
F
A
E
M
I
T
-
G
K
P
L
F
P
G
V
T
D
-----
D
D
Q
L
P
K
I
F
S
I
L
G
T
P
N
P
R
E
W
P
Q
V
Q
E
L
P
L
W
K
Q
--
R
T
F
----
Q
V
F
-
E
-
K
K
P
W
S
S
I
I
P
--------
G
--
F
C
Q
E
G
I
D
L
L
S
N
M
L
C
F
D
P
N
K
R
I
S
A
R
D
A
M
N
H
P
Y
F
K
D
L
D
P
Q
I
-------------------------------------------
21
PsiBlast_CBE
86.07
54%
-118
- C1 -
4AU8
2
CDK5_HUMAN
B:
[8-293]
----------------------------------------------------------------------------------------------------------------------------------------
Y
E
K
L
E
K
I
G
E
G
T
Y
G
T
V
F
K
A
K
N
R
--
E
T
H
E
I
V
A
L
K
R
V
R
L
-----
E
G
V
P
S
S
A
L
R
E
I
C
L
L
K
E
L
K
H
K
N
I
V
R
L
H
D
V
L
--
H
-----
S
--------
K
K
L
T
L
V
F
E
F
C
D
Q
D
L
K
K
Y
F
D
---
S
---
C
-----
N
-
G
D
L
D
P
E
I
V
K
S
F
L
F
Q
L
L
K
G
L
G
F
C
H
S
R
N
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
-
R
N
G
E
L
K
L
A
D
F
G
L
A
R
A
F
G
I
-
P
V
------
V
V
T
L
W
Y
R
P
P
D
V
L
F
G
A
K
L
Y
S
T
S
I
D
M
W
S
A
G
C
I
F
A
E
L
A
N
A
G
R
P
L
F
P
G
-
N
D
V
----
D
D
Q
L
K
R
I
F
R
L
L
G
T
P
T
E
E
Q
W
P
S
M
T
K
L
P
D
Y
K
P
----
Y
----
P
M
Y
P
A
-
T
T
S
L
V
N
V
V
P
---
K
L
---
N
--
A
T
--
G
R
D
L
L
Q
N
L
L
K
C
N
P
V
Q
R
I
S
A
E
E
A
L
Q
H
P
Y
F
S
D
F
-----------------------------------------------
60
PsiBlast_CBE
85.75
51%
-114
- C1 -
3R8P
1
CDK2_HUMAN
A:
[9-297]
-------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
-----T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
-----
T
------
E
-
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
---
A
---
S
-----
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
-
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
-
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-----
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
-
F
----
P
K
W
-
A
-
R
Q
D
F
S
K
V
V
P
---
P
L
---
D
----
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
--------------------------------------
95
PsiBlast_CBE
85.61
51%
-114
- C1 -
3QRT
3
CDK2_HUMAN
A:
[9-297]
-------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
-----T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
-----
T
------
E
-
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
---
A
---
S
-----
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
-
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
-
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-----
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
-
F
----
P
K
W
-
A
-
R
Q
D
F
S
K
V
V
P
---
P
L
---
D
----
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
--------------------------------------
76
PsiBlast_CBE
85.60
51%
-115
- C1 -
3QZI
2
CDK2_HUMAN
A:
[9-297]
-------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
-----T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
-----
T
------
E
-
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
---
A
---
S
-----
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
-
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
-
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-----
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
-
F
----
P
K
W
-
A
-
R
Q
D
F
S
K
V
V
P
---
P
L
---
D
----
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
--------------------------------------
28
PsiBlast_CBE
85.51
51%
-102
- C1 -
4GCJ
5
CDK2_HUMAN
A:
[5-297]
-----------------------------------------------------------------------------------------------------------------------------
S
P
E
F
----
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
-----
T
------
E
-
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
---
A
---
S
-----
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
-
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
-
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-----
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
-
F
----
P
K
W
-
A
-
R
Q
D
F
S
K
V
V
P
---
P
L
---
D
----
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
--------------------------------------
96
PsiBlast_CBE
85.34
51%
-114
- C1 -
3QQL
1
CDK2_HUMAN
A:
[9-297]
-------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
-----T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
-----
T
------
E
-
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
---
A
---
S
-----
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
-
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
-
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-----
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
-
F
----
P
K
W
-
A
-
R
Q
D
F
S
K
V
V
P
---
P
L
---
D
----
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
--------------------------------------
5
PsiBlast_PDB
85.31
54%
-111
- C1 -
1UNL
1
CDK5_HUMAN
A:
[4-291]
----------------------------------------------------------------------------------------------------------------------------------------
Y
E
K
L
E
K
I
G
E
G
T
Y
G
T
V
F
K
A
K
N
R
--
E
T
H
E
I
V
A
L
K
R
V
R
L
D
-
D
D
D
E
G
V
P
S
S
A
L
R
E
I
C
L
L
K
E
L
K
H
K
N
I
V
R
L
H
D
V
L
--
H
-----
S
------
D
-
K
K
L
T
L
V
F
E
F
C
D
Q
D
L
K
K
Y
F
D
---
S
---
C
-----
N
-
G
D
L
D
P
E
I
V
K
S
F
L
F
Q
L
L
K
G
L
G
F
C
H
S
R
N
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
-
R
N
G
E
L
K
L
A
N
F
G
L
A
R
A
F
G
I
-
P
V
R
C
Y
S
A
E
V
V
T
L
W
Y
R
P
P
D
V
L
F
G
A
K
L
Y
S
T
S
I
D
M
W
S
A
G
C
I
F
A
E
L
A
N
A
G
R
P
L
F
P
G
-
N
D
V
----
D
D
Q
L
K
R
I
F
R
L
L
G
T
P
T
E
E
Q
W
P
S
M
T
K
L
P
D
Y
K
P
----
Y
----
P
M
Y
P
A
-
T
T
S
L
V
N
V
V
P
---
K
L
---
N
--
A
T
--
G
R
D
L
L
Q
N
L
L
K
C
N
P
V
Q
R
I
S
A
E
E
A
L
Q
H
P
Y
F
S
D
F
C
P
P
--------------------------------------------
72
PsiBlast_CBE
85.25
51%
-112
- C1 -
3R28
2
CDK2_HUMAN
A:
[9-297]
-------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
-----T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
-----
T
------
E
-
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
---
A
---
S
-----
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
-
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
-
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-----
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
-
F
----
P
K
W
-
A
-
R
Q
D
F
S
K
V
V
P
---
P
L
---
D
----
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
--------------------------------------
47
PsiBlast_CBE
85.21
51%
-111
- C1 -
3RK5
1
CDK2_HUMAN
A:
[9-297]
-------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
-----T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
-----
T
------
E
-
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
---
A
---
S
-----
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
-
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
-
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-----
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
-
F
----
P
K
W
-
A
-
R
Q
D
F
S
K
V
V
P
---
P
L
---
D
----
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
--------------------------------------
30
PsiBlast_CBE
85.21
51%
-111
- C1 -
4EZ3
2
CDK2_HUMAN
A:
[9-297]
-------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
-----T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
-----
T
------
E
-
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
---
A
---
S
-----
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
-
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
-
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-----
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
-
F
----
P
K
W
-
A
-
R
Q
D
F
S
K
V
V
P
---
P
L
---
D
----
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
--------------------------------------
101
PsiBlast_CBE
85.18
51%
-110
- C1 -
3QQF
2
CDK2_HUMAN
A:
[9-297]
-------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
-----T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
-----
T
------
E
-
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
---
A
---
S
-----
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
-
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
-
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-----
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
-
F
----
P
K
W
-
A
-
R
Q
D
F
S
K
V
V
P
---
P
L
---
D
----
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
--------------------------------------
62
PsiBlast_CBE
85.16
51%
-114
- C1 -
3R8L
1
CDK2_HUMAN
A:
[9-297]
-------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
-----T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
-----
T
------
E
-
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
---
A
---
S
-----
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
-
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
-
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-----
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
-
F
----
P
K
W
-
A
-
R
Q
D
F
S
K
V
V
P
---
P
L
---
D
----
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
--------------------------------------
77
PsiBlast_CBE
85.05
51%
-112
- C1 -
3QZH
2
CDK2_HUMAN
A:
[9-297]
-------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
-----T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
-----
T
------
E
-
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
---
A
---
S
-----
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
-
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
-
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-----
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
-
F
----
P
K
W
-
A
-
R
Q
D
F
S
K
V
V
P
---
P
L
---
D
----
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
--------------------------------------
29
PsiBlast_CBE
85.00
51%
-106
- C1 -
4EZ7
7
CDK2_HUMAN
A:
[5-297]
-----------------------------------------------------------------------------------------------------------------------------
S
P
E
F
----
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
-----
T
------
E
-
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
---
A
---
S
-----
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
-
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
-
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-----
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
-
F
----
P
K
W
-
A
-
R
Q
D
F
S
K
V
V
P
---
P
L
---
D
----
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
--------------------------------------
64
PsiBlast_CBE
84.93
51%
-113
- C1 -
3R7Y
2
CDK2_HUMAN
A:
[9-297]
-------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
-----T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
-----
T
------
E
-
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
---
A
---
S
-----
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
-
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
-
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-----
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
-
F
----
P
K
W
-
A
-
R
Q
D
F
S
K
V
V
P
---
P
L
---
D
----
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
--------------------------------------
83
PsiBlast_CBE
84.91
51%
-112
- C1 -
3QX2
2
CDK2_HUMAN
A:
[9-297]
-------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
-----T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
-----
T
------
E
-
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
---
A
---
S
-----
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
-
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
-
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-----
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
-
F
----
P
K
W
-
A
-
R
Q
D
F
S
K
V
V
P
---
P
L
---
D
----
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
--------------------------------------
65
PsiBlast_CBE
84.84
51%
-114
- C1 -
3R7V
2
CDK2_HUMAN
A:
[9-297]
-------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
-----T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
-----
T
------
E
-
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
---
A
---
S
-----
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
-
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
-
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-----
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
-
F
----
P
K
W
-
A
-
R
Q
D
F
S
K
V
V
P
---
P
L
---
D
----
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
--------------------------------------
45
PsiBlast_CBE
84.82
51%
-109
- C1 -
3RK9
1
CDK2_HUMAN
A:
[9-297]
-------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
-----T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
-----
T
------
E
-
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
---
A
---
S
-----
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
-
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
-
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-----
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
-
F
----
P
K
W
-
A
-
R
Q
D
F
S
K
V
V
P
---
P
L
---
D
----
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
--------------------------------------
42
PsiBlast_CBE
84.73
51%
-114
- C1 -
3RM7
2
CDK2_HUMAN
A:
[9-297]
-------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
-----T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
-----
T
------
E
-
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
---
A
---
S
-----
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
-
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
-
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-----
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
-
F
----
P
K
W
-
A
-
R
Q
D
F
S
K
V
V
P
---
P
L
---
D
----
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
--------------------------------------
74
PsiBlast_CBE
84.70
51%
-112
- C1 -
3R1S
2
CDK2_HUMAN
A:
[9-297]
-------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
-----T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
-----
T
------
E
-
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
---
A
---
S
-----
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
-
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
-
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-----
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
-
F
----
P
K
W
-
A
-
R
Q
D
F
S
K
V
V
P
---
P
L
---
D
----
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
--------------------------------------
84
PsiBlast_CBE
84.68
51%
-112
- C1 -
3QWK
5
CDK2_HUMAN
A:
[9-297]
-------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
-----T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
-----
T
------
E
-
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
---
A
---
S
-----
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
-
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
-
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-----
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
-
F
----
P
K
W
-
A
-
R
Q
D
F
S
K
V
V
P
---
P
L
---
D
----
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
--------------------------------------
73
PsiBlast_CBE
84.65
51%
-111
- C1 -
3R1Y
2
CDK2_HUMAN
A:
[9-297]
-------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
-----T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
-----
T
------
E
-
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
---
A
---
S
-----
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
-
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
-
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-----
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
-
F
----
P
K
W
-
A
-
R
Q
D
F
S
K
V
V
P
---
P
L
---
D
----
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
--------------------------------------
48
PsiBlast_CBE
84.60
51%
-113
- C1 -
3RJC
1
CDK2_HUMAN
A:
[9-297]
-------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
-----T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
-----
T
------
E
-
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
---
A
---
S
-----
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
-
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
-
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-----
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
-
F
----
P
K
W
-
A
-
R
Q
D
F
S
K
V
V
P
---
P
L
---
D
----
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
--------------------------------------
69
PsiBlast_CBE
84.58
51%
-112
- C1 -
3R73
2
CDK2_HUMAN
A:
[9-297]
-------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
-----T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
-----
T
------
E
-
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
---
A
---
S
-----
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
-
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
-
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-----
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
-
F
----
P
K
W
-
A
-
R
Q
D
F
S
K
V
V
P
---
P
L
---
D
----
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
--------------------------------------
38
PsiBlast_CBE
84.55
51%
-110
- C1 -
3RPO
2
CDK2_HUMAN
A:
[9-297]
-------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
-----T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
-----
T
------
E
-
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
---
A
---
S
-----
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
-
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
-
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-----
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
-
F
----
P
K
W
-
A
-
R
Q
D
F
S
K
V
V
P
---
P
L
---
D
----
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
--------------------------------------
51
PsiBlast_CBE
84.47
51%
-111
- C1 -
3RAI
2
CDK2_HUMAN
A:
[9-297]
-------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
-----T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
-----
T
------
E
-
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
---
A
---
S
-----
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
-
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
-
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-----
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
-
F
----
P
K
W
-
A
-
R
Q
D
F
S
K
V
V
P
---
P
L
---
D
----
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
--------------------------------------
75
PsiBlast_CBE
84.45
51%
-111
- C1 -
3R1Q
2
CDK2_HUMAN
A:
[9-297]
-------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
-----T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
-----
T
------
E
-
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
---
A
---
S
-----
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
-
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
-
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-----
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
-
F
----
P
K
W
-
A
-
R
Q
D
F
S
K
V
V
P
---
P
L
---
D
----
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
--------------------------------------
70
PsiBlast_CBE
84.45
51%
-111
- C1 -
3R71
2
CDK2_HUMAN
A:
[9-297]
-------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
-----T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
-----
T
------
E
-
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
---
A
---
S
-----
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
-
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
-
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-----
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
-
F
----
P
K
W
-
A
-
R
Q
D
F
S
K
V
V
P
---
P
L
---
D
----
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
--------------------------------------
68
PsiBlast_CBE
84.35
51%
-114
- C1 -
3R7E
2
CDK2_HUMAN
A:
[9-297]
-------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
-----T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
-----
T
------
E
-
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
---
A
---
S
-----
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
-
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
-
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-----
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
-
F
----
P
K
W
-
A
-
R
Q
D
F
S
K
V
V
P
---
P
L
---
D
----
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
--------------------------------------
97
PsiBlast_CBE
84.29
51%
-110
- C1 -
3QQK
6
CDK2_HUMAN
A:
[9-297]
-------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
-----T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
-----
T
------
E
-
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
---
A
---
S
-----
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
-
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
-
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-----
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
-
F
----
P
K
W
-
A
-
R
Q
D
F
S
K
V
V
P
---
P
L
---
D
----
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
--------------------------------------
94
PsiBlast_CBE
84.26
51%
-109
- C1 -
3QRU
2
CDK2_HUMAN
A:
[9-297]
-------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
L
----T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
-----
T
------
E
-
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
---
A
---
S
-----
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
-
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
-
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-----
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
-
F
----
P
K
W
-
A
-
R
Q
D
F
S
K
V
V
P
---
P
L
---
D
----
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
--------------------------------------
36
PsiBlast_CBE
84.25
51%
-110
- C1 -
3RPV
2
CDK2_HUMAN
A:
[9-297]
-------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
-----T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
-----
T
------
E
-
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
---
A
---
S
-----
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
-
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
-
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-----
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
-
F
----
P
K
W
-
A
-
R
Q
D
F
S
K
V
V
P
---
P
L
---
D
----
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
--------------------------------------
78
PsiBlast_CBE
84.19
51%
-112
- C1 -
3QZG
2
CDK2_HUMAN
A:
[9-297]
-------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
-----T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
-----
T
------
E
-
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
---
A
---
S
-----
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
-
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
-
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-----
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
-
F
----
P
K
W
-
A
-
R
Q
D
F
S
K
V
V
P
---
P
L
---
D
----
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
--------------------------------------
71
PsiBlast_CBE
84.19
51%
-112
- C1 -
3R6X
2
CDK2_HUMAN
A:
[9-297]
-------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
-----T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
-----
T
------
E
-
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
---
A
---
S
-----
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
-
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
-
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-----
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
-
F
----
P
K
W
-
A
-
R
Q
D
F
S
K
V
V
P
---
P
L
---
D
----
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
--------------------------------------
81
PsiBlast_CBE
84.15
51%
-111
- C1 -
3QXO
2
CDK2_HUMAN
A:
[9-297]
-------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
-----T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
-----
T
------
E
-
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
---
A
---
S
-----
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
-
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
-
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-----
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
-
F
----
P
K
W
-
A
-
R
Q
D
F
S
K
V
V
P
---
P
L
---
D
----
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
--------------------------------------
63
PsiBlast_CBE
84.14
51%
-111
- C1 -
3R83
2
CDK2_HUMAN
A:
[9-297]
-------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
-----T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
-----
T
------
E
-
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
---
A
---
S
-----
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
-
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
-
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-----
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
-
F
----
P
K
W
-
A
-
R
Q
D
F
S
K
V
V
P
---
P
L
---
D
----
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
--------------------------------------
2
PsiBlast_PDB
84.12
54%
-111
- C1 -
4AU8
2
CDK5_HUMAN
A:
[8-293]
----------------------------------------------------------------------------------------------------------------------------------------
Y
E
K
L
E
K
I
G
E
G
T
Y
G
T
V
F
K
A
K
N
R
--
E
T
H
E
I
V
A
L
K
R
V
----------
P
S
S
A
L
R
E
I
C
L
L
K
E
L
K
H
K
N
I
V
R
L
H
D
V
L
--
H
---------------
K
L
T
L
V
F
E
F
C
D
Q
D
L
K
K
Y
F
D
---
S
---
C
-----
N
-
G
D
L
D
P
E
I
V
K
S
F
L
F
Q
L
L
K
G
L
G
F
C
H
S
R
N
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
-
R
N
G
E
L
K
L
A
D
F
G
L
A
R
A
F
G
I
-
P
V
R
--
S
A
E
V
V
T
L
W
Y
R
P
P
D
V
L
F
G
A
K
L
Y
S
T
S
I
D
M
W
S
A
G
C
I
F
A
E
L
A
N
A
G
R
P
L
F
P
G
-
N
D
V
----
D
D
Q
L
K
R
I
F
R
L
L
G
T
P
T
E
E
Q
W
P
S
M
T
K
L
P
D
Y
K
P
----
Y
----
P
M
Y
P
A
-
T
T
S
L
V
N
V
V
P
---
K
L
---
N
--
A
T
--
G
R
D
L
L
Q
N
L
L
K
C
N
P
V
Q
R
I
S
A
E
E
A
L
Q
H
P
Y
F
S
D
F
-----------------------------------------------
39
PsiBlast_CBE
84.03
51%
-110
- C1 -
3ROY
2
CDK2_HUMAN
A:
[9-297]
-------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
-----T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
-----
T
------
E
-
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
---
A
---
S
-----
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
-
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
-
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-----
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
-
F
----
P
K
W
-
A
-
R
Q
D
F
S
K
V
V
P
---
P
L
---
D
----
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
--------------------------------------
46
PsiBlast_CBE
84.01
51%
-108
- C1 -
3RK7
2
CDK2_HUMAN
A:
[9-297]
-------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
-----T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
-----
T
------
E
-
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
---
A
---
S
-----
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
-
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
-
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-----
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
-
F
----
P
K
W
-
A
-
R
Q
D
F
S
K
V
V
P
---
P
L
---
D
----
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
--------------------------------------
56
PsiBlast_CBE
83.99
51%
-110
- C1 -
3R9D
1
CDK2_HUMAN
A:
[9-297]
-------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
-----T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
-----
T
------
E
-
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
---
A
---
S
-----
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
-
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
-
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-----
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
-
F
----
P
K
W
-
A
-
R
Q
D
F
S
K
V
V
P
---
P
L
---
D
----
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
--------------------------------------
57
PsiBlast_CBE
83.90
51%
-112
- C1 -
3R8Z
1
CDK2_HUMAN
A:
[9-297]
-------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
-----T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
-----
T
------
E
-
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
---
A
---
S
-----
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
-
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
-
P
----
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-----
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
-
F
----
P
K
W
-
A
-
R
Q
D
F
S
K
V
V
P
---
P
L
---
D
----
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
--------------------------------------
55
PsiBlast_CBE
83.89
51%
-112
- C1 -
3R9H
1
CDK2_HUMAN
A:
[9-297]
-------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
-----T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
-----
T
------
E
-
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
---
A
---
S
-----
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
-
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
-
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-----
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
-
F
----
P
K
W
-
A
-
R
Q
D
F
S
K
V
V
P
---
P
L
---
D
----
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
--------------------------------------
93
PsiBlast_CBE
83.85
51%
-109
- C1 -
3QTQ
2
CDK2_HUMAN
A:
[9-297]
-------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
-----T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
-----
T
------
E
-
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
---
A
---
S
-----
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
-
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
-
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-----
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
-
F
----
P
K
W
-
A
-
R
Q
D
F
S
K
V
V
P
---
P
L
---
D
----
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
--------------------------------------
40
PsiBlast_CBE
83.76
51%
-108
- C1 -
3RNI
1
CDK2_HUMAN
A:
[9-297]
-------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
-----T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
-----
T
------
E
-
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
---
A
---
S
-----
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
-
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
-
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-----
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
-
F
----
P
K
W
-
A
-
R
Q
D
F
S
K
V
V
P
---
P
L
---
D
----
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
--------------------------------------
92
PsiBlast_CBE
83.63
51%
-112
- C1 -
3QTR
1
CDK2_HUMAN
A:
[9-297]
-------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
---------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
-----
T
------
E
-
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
---
A
---
S
-----
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
-
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
---------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-----
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
-
F
----
P
K
W
-
A
-
R
Q
D
F
S
K
V
V
P
---
P
L
---
D
----
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
--------------------------------------
44
PsiBlast_CBE
83.59
51%
-112
- C1 -
3RKB
2
CDK2_HUMAN
A:
[9-297]
-------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
-----T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
-----
T
------
E
-
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
---
A
---
S
-----
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
-
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
-
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-----
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
-
F
----
P
K
W
-
A
-
R
Q
D
F
S
K
V
V
P
---
P
L
---
D
----
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
--------------------------------------
98
PsiBlast_CBE
83.55
51%
-107
- C1 -
3QQJ
2
CDK2_HUMAN
A:
[9-297]
-------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
-----T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
-----
T
------
E
-
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
---
A
---
S
-----
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
-
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
-
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-----
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
-
F
----
P
K
W
-
A
-
R
Q
D
F
S
K
V
V
P
---
P
L
---
D
----
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
--------------------------------------
22
PsiBlast_CBE
83.51
54%
-118
- C1 -
3O0G
1
CDK5_HUMAN
B:
[6-288]
------------------------------------------------------------------------------------------------------------------------------------------
K
L
E
K
I
G
-----
T
V
F
K
A
--------
E
I
V
A
L
K
R
V
R
---------
P
S
S
A
L
R
E
I
C
L
L
K
E
L
K
H
K
N
I
V
R
L
H
D
V
L
--
H
-----
S
------
D
-
K
K
L
T
L
V
F
E
F
C
D
Q
D
L
K
K
Y
F
D
---
S
---
C
-----
N
-
G
D
L
D
P
E
I
V
K
S
F
L
F
Q
L
L
K
G
L
G
F
C
H
S
R
N
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
-
R
N
G
E
L
K
L
A
N
F
G
L
A
R
A
F
G
I
-
P
V
R
C
Y
S
A
E
V
V
T
L
W
Y
R
P
P
D
V
L
F
G
A
K
L
Y
S
T
S
I
D
M
W
S
A
G
C
I
F
A
E
L
A
N
A
G
R
P
L
F
P
G
-
N
D
V
----
D
D
Q
L
K
R
I
F
R
L
L
G
T
P
T
E
E
Q
W
P
S
M
T
K
L
P
D
Y
K
P
----
Y
----
P
M
Y
P
A
-
T
T
S
L
V
N
V
V
P
---
K
L
---
N
--
A
T
--
G
R
D
L
L
Q
N
L
L
K
C
N
P
V
Q
R
I
S
A
E
E
A
L
Q
H
P
Y
F
S
D
------------------------------------------------
31
PsiBlast_CBE
83.44
51%
-110
- C1 -
3SQQ
2
CDK2_HUMAN
A:
[9-297]
-------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
-----T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
-----
T
------
E
-
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
---
A
---
S
-----
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
-
T
E
G
A
I
K
L
A
D
F
G
L
A
R
-------
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-----
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
-
F
----
P
K
W
-
A
-
R
Q
D
F
S
K
V
V
P
---
P
L
---
D
----
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
--------------------------------------
59
PsiBlast_CBE
83.43
51%
-109
- C1 -
3R8U
1
CDK2_HUMAN
A:
[9-297]
-------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
-----T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
-----
T
------
E
-
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
---
A
---
S
-----
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
-
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
-
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-----
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
-
F
----
P
K
W
-
A
-
R
Q
D
F
S
K
V
V
P
---
P
L
---
D
----
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
--------------------------------------
79
PsiBlast_CBE
83.41
51%
-110
- C1 -
3QZF
1
CDK2_HUMAN
A:
[9-297]
-------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
-----T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
-----
T
------
E
-
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
---
A
---
S
-----
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
-
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
-
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-----
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
-
F
----
P
K
W
-
A
-
R
Q
D
F
S
K
V
V
P
---
P
L
---
D
----
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
--------------------------------------
67
PsiBlast_CBE
83.36
51%
-116
- C1 -
3R7I
2
CDK2_HUMAN
A:
[9-297]
-------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
---------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
-----
T
------
E
-
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
---
A
---
S
-----
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
-
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
---------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-----
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
-
F
----
P
K
W
-
A
-
R
Q
D
F
S
K
V
V
P
---
P
L
---
D
----
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
--------------------------------------
35
PsiBlast_CBE
83.35
51%
-120
- C1 -
3RPY
1
CDK2_HUMAN
A:
[9-297]
-------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
---------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
-----
T
------
E
-
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
---
A
---
S
-----
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
-
T
E
G
A
I
K
L
A
D
F
G
L
A
--------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-----
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
-
F
----
P
K
W
-
A
-
R
Q
D
F
S
K
V
V
P
---
P
L
---
D
----
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
--------------------------------------
100
PsiBlast_CBE
83.31
51%
-108
- C1 -
3QQG
2
CDK2_HUMAN
A:
[9-297]
-------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
-----T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
-----
T
------
E
-
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
---
A
---
S
-----
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
-
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
-
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-----
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
-
F
----
P
K
W
-
A
-
R
Q
D
F
S
K
V
V
P
---
P
L
---
D
----
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
--------------------------------------
90
PsiBlast_CBE
83.25
51%
-111
- C1 -
3QTU
1
CDK2_HUMAN
A:
[9-297]
-------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
-----T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
-----
T
------
E
-
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
---
A
---
S
-----
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
-
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
-
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-----
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
-
F
----
P
K
W
-
A
-
R
Q
D
F
S
K
V
V
P
---
P
L
---
D
----
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
--------------------------------------
86
PsiBlast_CBE
83.25
51%
-109
- C1 -
3QU0
5
CDK2_HUMAN
A:
[9-297]
-------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
-----T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
-----
T
------
E
-
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
---
A
---
S
-----
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
-
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
-
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-----
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
-
F
----
P
K
W
-
A
-
R
Q
D
F
S
K
V
V
P
---
P
L
---
D
----
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
--------------------------------------
82
PsiBlast_CBE
83.24
51%
-110
- C1 -
3QX4
3
CDK2_HUMAN
A:
[9-297]
-------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
-----T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
-----
T
------
E
-
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
---
A
---
S
-----
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
-
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
-
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-----
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
-
F
----
P
K
W
-
A
-
R
Q
D
F
S
K
V
V
P
---
P
L
---
D
----
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
--------------------------------------
118
HHSearch
83.11
55%
-106
- C1 -
4AU8
2
CDK5_HUMAN
A:
[5-293]
-------------------------------------------------------------------------------------------------------------------------------------
S
Q
K
Y
E
K
L
E
K
I
G
E
G
T
Y
G
T
V
F
K
A
K
N
R
--
E
T
H
E
I
V
A
L
K
R
V
----------
P
S
S
A
L
R
E
I
C
L
L
K
E
L
K
H
K
N
I
V
R
L
H
D
V
L
--
H
---------------
K
L
T
L
V
F
E
F
C
D
Q
D
L
K
K
Y
F
D
---
S
---
C
-----
N
-
G
D
L
D
P
E
I
V
K
S
F
L
F
Q
L
L
K
G
L
G
F
C
H
S
R
N
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
-
R
N
G
E
L
K
L
A
D
F
G
L
A
R
A
F
G
I
-
P
V
R
--
S
A
E
V
V
T
L
W
Y
R
P
P
D
V
L
F
G
A
K
L
Y
S
T
S
I
D
M
W
S
A
G
C
I
F
A
E
L
A
N
A
G
R
P
L
F
P
G
N
-
D
V
----
D
D
Q
L
K
R
I
F
R
L
L
G
T
P
T
E
E
Q
W
P
S
M
T
K
L
P
D
Y
K
P
--
Y
P
------
M
Y
-
P
A
T
T
S
L
---
V
N
---
V
V
P--
K
--
L
N
A
T
G
R
D
L
L
Q
N
L
L
K
C
N
P
V
Q
R
I
S
A
E
E
A
L
Q
H
P
Y
F
S
D
F
-----------------------------------------------
80
PsiBlast_CBE
83.08
51%
-109
- C1 -
3QXP
2
CDK2_HUMAN
A:
[9-297]
-------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
-----T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
-----
T
------
E
-
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
---
A
---
S
-----
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
-
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
-
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-----
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
-
F
----
P
K
W
-
A
-
R
Q
D
F
S
K
V
V
P
---
P
L
---
D
----
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
--------------------------------------
33
PsiBlast_CBE
83.06
51%
-113
- C1 -
3S00
1
CDK2_HUMAN
A:
[9-297]
-------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
-----T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
-----
T
------
E
-
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
---
A
---
S
-----
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
-
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
-
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-----
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
-
F
----
P
K
W
-
A
-
R
Q
D
F
S
K
V
V
P
---
P
L
---
D
----
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
--------------------------------------
89
PsiBlast_CBE
83.03
51%
-110
- C1 -
3QTW
6
CDK2_HUMAN
A:
[9-297]
-------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
-----T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
-----
T
------
E
-
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
---
A
---
S
-----
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
-
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
-
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-----
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
-
F
----
P
K
W
-
A
-
R
Q
D
F
S
K
V
V
P
---
P
L
---
D
----
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
--------------------------------------
87
PsiBlast_CBE
83.02
51%
-112
- C1 -
3QTZ
3
CDK2_HUMAN
A:
[9-297]
-------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
-----T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
-----
T
------
E
-
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
---
A
---
S
-----
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
-
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
-
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-----
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
-
F
----
P
K
W
-
A
-
R
Q
D
F
S
K
V
V
P
---
P
L
---
D
----
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
--------------------------------------
37
PsiBlast_CBE
83.02
51%
-114
- C1 -
3RPR
1
CDK2_HUMAN
A:
[9-297]
-------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
---------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
-----
T
------
E
-
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
---
A
---
S
-----
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
-
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
---------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-----
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
-
F
----
P
K
W
-
A
-
R
Q
D
F
S
K
V
V
P
---
P
L
---
D
----
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
--------------------------------------
85
PsiBlast_CBE
83.00
51%
-109
- C1 -
3QWJ
2
CDK2_HUMAN
A:
[9-297]
-------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
-----T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
-----
T
------
E
-
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
---
A
---
S
-----
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
-
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
-
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-----
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
-
F
----
P
K
W
-
A
-
R
Q
D
F
S
K
V
V
P
---
P
L
---
D
----
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
--------------------------------------
66
PsiBlast_CBE
82.95
51%
-115
- C1 -
3R7U
2
CDK2_HUMAN
A:
[9-297]
-------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
---------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
-----
T
------
E
-
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
---
A
---
S
-----
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
-
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
---------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-----
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
-
F
----
P
K
W
-
A
-
R
Q
D
F
S
K
V
V
P
---
P
L
---
D
----
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
--------------------------------------
52
PsiBlast_CBE
82.92
51%
-114
- C1 -
3RAH
1
CDK2_HUMAN
A:
[9-297]
-------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
---------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
-----
T
------
E
-
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
---
A
---
S
-----
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
-
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
---------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-----
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
-
F
----
P
K
W
-
A
-
R
Q
D
F
S
K
V
V
P
---
P
L
---
D
----
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
--------------------------------------
99
PsiBlast_CBE
82.87
51%
-105
- C1 -
3QQH
4
CDK2_HUMAN
A:
[9-297]
-------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
-----T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
-----
T
------
E
-
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
---
A
---
S
-----
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
-
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
-
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-----
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
-
F
----
P
K
W
-
A
-
R
Q
D
F
S
K
V
V
P
---
P
L
---
D
----
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
--------------------------------------
58
PsiBlast_CBE
82.87
51%
-110
- C1 -
3R8V
1
CDK2_HUMAN
A:
[9-297]
-------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
-----T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
-----
T
------
E
-
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
---
A
---
S
-----
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
-
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
-
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-----
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
-
F
----
P
K
W
-
A
-
R
Q
D
F
S
K
V
V
P
---
P
L
---
D
----
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
--------------------------------------
88
PsiBlast_CBE
82.80
51%
-110
- C1 -
3QTX
1
CDK2_HUMAN
A:
[9-297]
-------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
-----T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
-----
T
------
E
-
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
---
A
---
S
-----
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
-
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
-
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-----
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
-
F
----
P
K
W
-
A
-
R
Q
D
F
S
K
V
V
P
---
P
L
---
D
----
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
--------------------------------------
50
PsiBlast_CBE
82.72
51%
-119
- C1 -
3RAK
1
CDK2_HUMAN
A:
[9-297]
-------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
---------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
-----
T
------
E
-
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
---
A
---
S
-----
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
-
T
E
G
A
I
K
L
A
D
F
G
L
A
--------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-----
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
-
F
----
P
K
W
-
A
-
R
Q
D
F
S
K
V
V
P
---
P
L
---
D
----
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
--------------------------------------
18
PsiBlast_PDB
82.70
51%
-107
- C1 -
4CFV
1
CDK2_HUMAN
A:
[4-294]
---------------------------------------------------------------------------------------------------------------------------------
G
S
--
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
-----
T
------
E
-
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
---
A
---
S
-----
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
-
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
-
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-----
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
-
F
----
P
K
W
-
A
-
R
Q
D
F
S
K
V
V
P
---
P
L
---
D
----
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
--------------------------------------
91
PsiBlast_CBE
82.48
51%
-115
- C1 -
3QTS
1
CDK2_HUMAN
A:
[9-297]
-------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
---------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
-----
T
------
E
-
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
---
A
---
S
-----
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
-
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
---------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-----
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
-
F
----
P
K
W
-
A
-
R
Q
D
F
S
K
V
V
P
---
P
L
---
D
----
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
--------------------------------------
43
PsiBlast_CBE
82.42
51%
-111
- C1 -
3RM6
2
CDK2_HUMAN
A:
[9-297]
-------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
-
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
-----T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
-----
T
------
E
-
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
---
A
---
S
-----
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
-
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
-
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-----
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
-
F
----
P
K
W
-
A
-
R
Q
D
F
S
K
V
V
P
---
P
L
---
D
----
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
--------------------------------------
54
PsiBlast_CBE
82.15
51%
-114
- C1 -
3R9N
1
CDK2_HUMAN
A:
[9-297]
-------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
---------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
-----
T
------
E
-
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
---
A
---
S
-----
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
-
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
---------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-----
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
-
F
----
P
K
W
-
A
-
R
Q
D
F
S
K
V
V
P
---
P
L
---
D
----
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
--------------------------------------
32
PsiBlast_CBE
81.93
51%
-117
- C1 -
3S1H
1
CDK2_HUMAN
A:
[9-297]
-------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
---------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
-----
T
------
E
-
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
---
A
---
S
-----
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
-
T
E
G
A
I
K
L
A
D
F
G
L
A
--------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-----
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
-
F
----
P
K
W
-
A
-
R
Q
D
F
S
K
V
V
P
---
P
L
---
D
----
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
--------------------------------------
17
PsiBlast_PDB
81.66
51%
-107
- C1 -
4CFU
1
CDK2_HUMAN
A:
[4-294]
---------------------------------------------------------------------------------------------------------------------------------
G
S
--
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
L
D
---T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
-----
T
------
E
-
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
---
A
---
S
-----
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
-
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
-
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-----
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
-
F
----
P
K
W
-
A
-
R
Q
D
F
S
K
V
V
P
---
P
L
---
D
----
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
--------------------------------------
26
PsiBlast_CBE
81.60
52%
-108
- C1 -
1V0O
1
CDC2H_PLAFK
B:
[3-286]
---------------------------------------------------------------------------------------------------------------------------------------
K
Y
H
G
L
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
Q
N
N
--
Y
-
G
E
T
F
A
L
K
K
I
R
L
-----------
T
I
R
E
I
S
I
L
K
E
L
K
H
S
N
I
V
K
L
Y
D
V
I
--
H
-----
T
------
K
-
K
R
L
V
L
V
F
E
H
L
D
Q
D
L
K
K
L
L
D
---
V
---
C
-----
E
-
G
G
L
E
S
V
T
A
K
S
F
L
L
Q
L
L
N
G
I
A
Y
C
H
D
R
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
-
R
E
G
E
L
K
I
A
D
F
G
L
A
R
A
F
G
I
-
P
V
R
K
Y
T
H
E
V
V
T
L
W
Y
R
A
P
D
V
L
M
G
S
K
K
Y
S
T
T
I
D
I
W
S
V
G
C
I
F
A
E
M
V
N
-
G
T
P
L
F
P
G
V
S
E
-----
A
D
Q
L
M
R
I
F
R
I
L
G
T
P
N
S
K
N
W
P
N
V
T
E
L
P
K
Y
D
P
---
N
F
----
T
V
Y
-
E
-
P
L
P
W
E
S
F
L
K
---
G
L
---
D
----
E
S
G
I
D
L
L
S
K
M
L
K
L
D
P
N
Q
R
I
T
A
K
Q
A
L
E
H
A
Y
F
K
E
N
-----------------------------------------------
15
PsiBlast_PDB
81.59
51%
-120
- C1 -
3EZR
2
CDK2_HUMAN
A:
[3-291]
-------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
--------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
-----
T
------
E
-
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
---
A
---
S
-----
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
-
T
E
G
A
I
K
L
A
D
F
-------------------
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-----
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
-
F
----
P
K
W
-
A
-
R
Q
D
F
S
K
V
V
P
---
P
L
---
D
----
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
--------------------------------------
27
PsiBlast_CBE
81.55
52%
-113
- C1 -
1V0P
1
CDC2H_PLAFK
B:
[2-286]
--------------------------------------------------------------------------------------------------------------------------------------
E
K
Y
H
G
L
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
Q
N
N
--
Y
-
G
E
T
F
A
L
K
------------
P
S
T
T
I
R
E
I
S
I
L
K
E
L
K
H
S
N
I
V
K
L
Y
D
V
I
--
H
-----
T
----------
L
V
L
V
F
E
H
L
D
Q
D
L
K
K
L
L
D
---
V
---
C
-----
E
-
G
G
L
E
S
V
T
A
K
S
F
L
L
Q
L
L
N
G
I
A
Y
C
H
D
R
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
-
R
E
G
E
L
K
I
A
D
F
G
L
A
R
A
F
--------------
L
W
Y
R
A
P
D
V
L
M
G
S
K
K
Y
S
T
T
I
D
I
W
S
V
G
C
I
F
A
E
M
V
N
-
G
T
P
L
F
P
G
V
S
E
-----
A
D
Q
L
M
R
I
F
R
I
L
G
T
P
N
S
K
N
W
P
N
V
T
E
L
P
K
Y
D
P
---
N
F
----
T
V
Y
-
E
-
P
L
P
W
E
S
F
L
K
---
G
L
---
D
----
E
S
G
I
D
L
L
S
K
M
L
K
L
D
P
N
Q
R
I
T
A
K
Q
A
L
E
H
A
Y
F
K
E
------------------------------------------------
41
PsiBlast_CBE
81.54
51%
-118
- C1 -
3RMF
1
CDK2_HUMAN
A:
[9-297]
-------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
L
--------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
-----
T
------
E
-
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
---
A
---
S
-----
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
-
T
E
G
A
I
K
L
A
D
F
G
L
A
--------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-----
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
-
F
----
P
K
W
-
A
-
R
Q
D
F
S
K
V
V
P
---
P
L
---
D
----
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
--------------------------------------
16
PsiBlast_PDB
81.48
51%
-113
- C1 -
3EZV
1
CDK2_HUMAN
A:
[3-291]
-------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
--------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
-----
T
------
E
-
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
---
A
---
S
-----
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
-
T
E
G
A
I
K
L
A
D
F
G
L
---------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-----
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
-
F
----
P
K
W
-
A
-
R
Q
D
F
S
K
V
V
P
---
P
L
---
D
----
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
--------------------------------------
34
PsiBlast_CBE
81.35
51%
-115
- C1 -
3RZB
1
CDK2_HUMAN
A:
[9-297]
-------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
---------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
-----
T
------
E
-
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
---
A
---
S
-----
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
-
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
---------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-----
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
-
F
----
P
K
W
-
A
-
R
Q
D
F
S
K
V
V
P
---
P
L
---
D
----
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
--------------------------------------
11
PsiBlast_PDB
81.32
52%
-102
- C1 -
4KRC
1
PHO85_YEAST
A:
[4-299]
-------------------------------------------------------------------------------------------------------------------------------------
S
S
Q
F
K
Q
L
E
K
L
G
N
G
T
Y
A
T
V
Y
K
G
L
N
K
--
T
T
G
V
Y
V
A
L
K
E
V
K
L
D
-
S
E
-
E
G
T
P
S
T
A
I
R
E
I
S
L
M
K
E
L
K
H
E
N
I
V
R
L
Y
D
V
I
--
H
-----
T
------
E
-
N
K
L
T
L
V
F
E
F
M
D
N
D
L
K
K
Y
M
D
---
S
---
R
T----
P
-
R
G
L
E
L
N
L
V
K
Y
F
Q
W
Q
L
L
Q
G
L
A
F
C
H
E
N
K
I
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
-
K
R
G
Q
L
K
L
G
D
F
G
L
A
R
A
F
G
I
-
P
V
N
T
F
S
S
E
V
V
T
L
W
Y
R
A
P
D
V
L
M
G
S
R
T
Y
S
T
S
I
D
I
W
S
C
G
C
I
L
A
E
M
I
T
-
G
K
P
L
F
P
G
T
N
D
-----
E
E
Q
L
K
L
I
F
D
I
M
G
T
P
N
E
S
L
W
P
S
V
T
K
L
P
K
Y
N
P
--
N
-
I
----
Q
Q
R
-
P
-
P
R
D
L
R
Q
V
L
Q
PHT
K
E
---
P
--
L
D
G
N
L
M
D
F
L
H
G
L
L
Q
L
N
P
D
M
R
L
S
A
K
Q
A
L
H
H
P
W
F
A
E
Y
Y
H
---------------------------------------------
49
PsiBlast_CBE
81.31
51%
-119
- C1 -
3RAL
1
CDK2_HUMAN
A:
[9-297]
-------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
---------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
-----
T
------
E
-
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
---
A
---
S
-----
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
-
T
E
G
A
I
K
L
A
D
F
G
L
A
--------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-----
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
-
F
----
P
K
W
-
A
-
R
Q
D
F
S
K
V
V
P
---
P
L
---
D
----
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
--------------------------------------
53
PsiBlast_CBE
81.19
51%
-112
- C1 -
3R9O
1
CDK2_HUMAN
A:
[9-297]
-------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
---------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
-----
T
------
E
-
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
---
A
---
S
-----
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
-
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
---------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-----
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
-
F
----
P
K
W
-
A
-
R
Q
D
F
S
K
V
V
P
---
P
L
---
D
----
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
--------------------------------------
14
PsiBlast_PDB
80.17
52%
-110
- C1 -
1V0O
1
CDC2H_PLAFK
A:
[3-286]
---------------------------------------------------------------------------------------------------------------------------------------
K
Y
H
G
L
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
Q
N
N
--
Y
-
G
E
T
F
A
L
K
K
I
R
L
---------
S
T
T
I
R
E
I
S
I
L
K
E
L
K
H
S
N
I
V
K
L
Y
D
V
I
--
H
-----
T
------
K
-
K
R
L
V
L
V
F
E
H
L
D
Q
D
L
K
K
L
L
D
---
V
---
C
-----
E
-
G
G
L
E
S
V
T
A
K
S
F
L
L
Q
L
L
N
G
I
A
Y
C
H
D
R
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
-
R
E
G
E
L
K
I
A
D
F
G
L
A
R
A
F
G
I
-
P
V
R
K
Y
T
H
E
V
V
T
L
W
Y
R
A
P
D
V
L
M
G
S
K
K
Y
S
T
T
I
D
I
W
S
V
G
C
I
F
A
E
M
V
N
-
G
T
P
L
F
P
G
V
S
E
-----
A
D
Q
L
M
R
I
F
R
I
L
G
T
P
N
S
K
N
W
P
N
V
T
E
L
P
K
Y
D
P
---
N
F
----
T
V
Y
-
E
-
P
L
P
W
E
S
F
L
K
---
G
L
---
D
----
E
S
G
I
D
L
L
S
K
M
L
K
L
D
P
N
Q
R
I
T
A
K
Q
A
L
E
H
A
Y
F
K
E
N
-----------------------------------------------
61
PsiBlast_CBE
78.28
51%
-109
- C1 -
3R8M
1
CDK2_HUMAN
A:
[9-297]
-------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
-----T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
-----
T
------
E
-
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
---
A
---
S
-----
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
-
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
---------
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-----
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
-
F
----
P
K
W
-
A
-
R
Q
D
F
S
K
V
V
P
---
P
L
---
D
----
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
--------------------------------------
10
PsiBlast_PDB
74.34
52%
-100
- C1 -
2PMI
2
PHO85_YEAST
A:
[19-299]
----------------------------------------------------------------------------------------------------------------------------------------------------
A
T
V
Y
K
G
L
N
K
--
T
T
G
V
Y
V
A
L
K
E
V
K
L
D
-
S
E
-
E
G
T
P
S
T
A
I
R
E
I
S
L
M
K
E
L
K
H
E
N
I
V
R
L
Y
D
V
I
--
H
-----
T
------
E
-
N
K
L
T
L
V
F
E
F
M
D
N
D
L
K
K
Y
M
D
---
S
---
R
TVGN
T
P
-
R
G
L
E
L
N
L
V
K
Y
F
Q
W
Q
L
L
Q
G
L
A
F
C
H
E
N
K
I
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
-
K
R
G
Q
L
K
L
G
D
F
G
L
A
R
A
F
G
I
-
P
V
N
T
F
S
S
E
V
V
T
L
W
Y
R
A
P
D
V
L
M
G
S
R
T
Y
S
T
S
I
D
I
W
S
C
G
C
I
L
A
E
M
I
T
-
G
K
P
L
F
P
G
T
N
D
-----
E
E
Q
L
K
L
I
F
D
I
M
G
T
P
N
E
S
L
W
P
S
V
T
K
L
P
K
Y
N
P
--
N
-
I
----
Q
Q
R
-
P
-
P
R
D
L
R
Q
V
L
Q
PHT
K
E
---
P
--
L
D
G
N
L
M
D
F
L
H
G
L
L
Q
L
N
P
D
M
R
L
S
A
K
Q
A
L
H
H
P
W
F
A
E
Y
Y
H
---------------------------------------------
115
HHSearch
73.10
33%
-109
- C1 -
3EB0
3
?
A:
[7-329]
--------------------------------------------------------------------------------------------------------------------------------------
K
K
Y
S
L
G
K
T
L
G
T
G
-
F
G
I
V
C
E
V
F
D
I
--
E
S
G
K
R
F
A
L
K
K
V
L
Q
D
-
P
R
------
Y
K
N
R
E
L
D
I
M
K
V
L
D
H
V
N
I
I
K
L
V
D
Y
F
--
Y
-----
T
------
T
N
K
Y
L
N
V
I
M
E
Y
V
P
D
T
L
H
K
V
L
K
---
S
F
I
R
S
-----
G
-
R
S
I
P
M
N
L
I
S
I
Y
I
Y
Q
L
F
R
A
V
G
F
I
H
S
L
G
I
C
H
R
D
I
K
P
Q
N
L
L
V
----
N
S
K
D
N
T
L
K
L
C
D
F
G
S
A
K
K
L
I
--
P
S
E
P
S
V
A
Y
I
C
S
R
F
Y
R
A
P
E
L
M
L
G
A
T
E
Y
T
P
S
I
D
L
W
S
I
G
C
V
F
G
E
L
I
L
-
G
K
P
L
F
S
G
E
T
S
-----
I
D
Q
L
V
R
I
I
Q
I
M
G
T
P
T
K
E
Q
M
I
R
M
--
N
P
H
Y
----
V
R
F
----
P
T
L
-
K
-
A
K
D
W
R
K
I
L
P
---
E
----
G
--
T
P
S
L
A
I
D
L
L
E
Q
I
L
R
Y
E
P
D
L
R
I
N
P
Y
E
A
M
A
H
P
F
F
D
H
L
R
N
S
I
P
Q
L
F
N
F
S
P
Y
E
L
S
I
I
P
G
N
V
L
N
R
I
L
P
K
------------------
127
HHSearch
68.39
38%
-97
- C1 -
4NST
3
CDK12_HUMAN
A:
[6-314]
-------------------------------------------------------------------------------------------------------------------------------
D
W
G
K
RC
V
D
K
F
D
I
I
G
I
I
G
E
G
T
Y
G
Q
V
Y
K
A
K
D
K
--
D
T
G
E
L
V
A
L
K
K
V
R
L
D
-
N
E
K
E
G
F
P
I
T
A
I
R
E
I
K
I
L
R
Q
L
I
H
R
S
V
V
N
M
K
E
I
V
--
T
-----
D
KQD-----
G
A
F
Y
L
V
F
E
Y
M
D
H
D
L
M
G
L
L
E
---
S
---
G
-----
L
-
V
H
F
S
E
D
H
I
K
S
F
M
K
Q
L
M
E
G
L
E
Y
C
H
K
K
N
F
L
H
R
D
I
K
C
S
N
I
L
L
----
N
-
N
S
G
Q
I
K
L
A
D
F
G
L
A
R
L
Y
N
S
E
E
S
R
P
Y
T
N
K
V
I
T
L
W
Y
R
P
P
E
L
L
L
G
E
E
R
Y
T
P
A
I
D
V
W
S
C
G
C
I
L
G
E
L
F
T
-
K
K
P
I
F
Q
A
N
L
E
-----
L
A
Q
L
E
L
I
S
R
L
C
G
S
P
C
P
A
V
W
P
D
V
I
K
L
P
Y
F
N
T
--
M
K
P
----
K
K
Q
-
Y
-
R
R
R
L
R
E
E
F
S
---
F
I
-------
P
S
A
A
L
D
L
L
D
H
M
L
T
L
D
P
S
K
R
C
T
A
E
Q
T
L
Q
S
D
F
L
K
D
V
E
L
S
K
M
A
P
P
D
L
P
H
W
Q
D
C
H
E
L
W
S
K
K
------------------------
112
HHSearch
64.86
43%
-92
- C1 -
1UA2
1
CDK7_HUMAN
A:
[13-300]
-----------------------------------------------------------------------------------------------------------------------------------------
E
K
L
D
F
L
G
E
G
Q
F
A
T
V
Y
K
A
R
D
K
--
N
T
N
Q
I
V
A
I
K
K
I
----------
N
R
T
A
L
R
E
I
K
L
L
Q
E
L
S
H
P
N
I
I
G
L
L
D
A
F
--
G
-----
H
------
K
-
S
N
I
S
L
V
F
D
F
M
E
T
D
L
E
V
I
I
K
---
D
---
N
-----
S
-
L
V
L
T
P
S
H
I
K
A
Y
M
L
M
T
L
Q
G
L
E
Y
L
H
Q
H
W
I
L
H
R
D
L
K
P
N
N
L
L
L
----
D
-
E
N
G
V
L
K
L
A
D
F
G
L
A
K
S
F
G
S
-
P
N
R
A
Y
T
H
Q
V
V
T
R
W
Y
R
A
P
E
L
L
F
G
A
R
M
Y
G
V
G
V
D
M
W
A
V
G
C
I
L
A
E
L
L
L
-
R
V
P
F
L
P
G
D
S
D
-----
L
D
Q
L
T
R
I
F
E
T
L
G
T
P
T
E
E
Q
W
P
D
M
C
S
L
P
D
Y
V
T
----
F
----
K
S
F
-
P
-
G
I
P
L
H
H
I
F
S
---
A
-------
A
G
D
D
L
L
D
L
I
Q
G
L
F
L
F
N
P
C
A
R
I
T
A
T
Q
A
L
K
M
K
Y
F
S
N
R
P
G
P
T
P
G
C
Q
L
P
R
P
N
----------------------------------
129
HHSearch
63.74
31%
-102
- C1 -
2B9H
1
FUS3_YEAST
A:
[3-312]
----------------------------------------------------------------------------------------------------------------------------
K
R
I
V
Y
N
I
--
S
S
D
F
Q
L
K
S
L
L
G
E
G
A
Y
G
V
V
C
S
A
T
H
K
--
P
T
G
E
I
V
A
I
K
K
I
E
P
F
-
D
K
-
P
L
F
A
L
R
T
L
R
E
I
K
I
L
K
H
F
K
H
E
N
I
I
T
I
F
N
I
Q
--
R
PDSFE
N
------
F
-
N
E
V
Y
I
I
Q
E
L
M
Q
T
D
L
H
R
V
I
S
---
T
---
Q
--------
M
L
S
D
D
H
I
Q
Y
F
I
Y
Q
T
L
R
A
V
K
V
L
H
G
S
N
V
I
H
R
D
L
K
P
S
N
L
L
I
----
N
-
S
N
C
D
L
K
V
C
D
F
G
L
A
R
I
I
D
-------
V
E
F
V
A
T
R
W
Y
R
A
P
E
V
M
L
T
S
A
K
Y
S
R
A
M
D
V
W
S
C
G
C
I
L
A
E
L
F
L
-
R
R
P
I
F
P
G
R
-
D
Y
----
R
H
Q
L
L
L
I
F
G
I
I
G
T
P
H
S
D
N
D
L
R
C
I
E
S
P
R
A
R
E
Y
I
K
S
L
----
P
M
Y
-
P
-
A
A
P
L
E
K
M
F
P
---
R
-------
V
N
P
K
G
I
D
L
L
Q
R
M
L
V
F
D
P
A
K
R
I
T
A
K
E
A
L
E
H
P
Y
L
Q
T
Y
H
D
P
N
D
E
P
E
G
E
P
I
P
P
S
F
F
E
F
D
H
Y
K
E
A
L
T
T
K
D
L
K
K
L
I
W
N
E
I
F
S
------
128
HHSearch
62.15
37%
-103
- C1 -
4F6U
10
CDK8_HUMAN
A:
[27-341]
--------------------------------------------------------------------------------------------------------------------------------------------
C
K
V
G
R
G
T
Y
G
H
V
Y
K
A
K
R
K
DG
K
D
D
K
D
Y
A
L
K
Q
I
E
----
G
-
T
G
I
S
M
S
A
C
R
E
I
A
L
L
R
E
L
K
H
P
N
V
I
S
L
Q
K
V
F
L
S
H
-----
A
------
D
-
R
K
V
W
L
L
F
D
Y
A
E
H
D
L
W
H
I
I
K
---
F
---
H
R
A
S
K---
V
Q
L
P
R
G
M
V
K
S
L
L
Y
Q
I
L
D
G
I
H
Y
L
H
A
N
W
V
L
H
R
D
L
K
P
A
N
I
L
V
M
G
EG
P
-
E
R
G
R
V
K
I
A
D
M
G
F
---------------
V
V
T
F
W
Y
R
A
P
E
L
L
L
G
A
R
H
Y
T
K
A
I
D
I
W
A
I
G
C
I
F
A
E
L
L
T
-
S
E
P
I
F
H
C
R
Q
E
-NPYH
H
D
Q
L
D
R
I
F
N
V
M
G
F
P
A
D
K
D
W
E
D
I
K
K
M
P
E
H
S
T
--
L
M
K
D
F
RR
N
T
Y
-
T
-
N
C
S
L
I
K
Y
M
E
---
K
H
---
K
VK
P
D
S
K
A
F
H
L
L
Q
K
L
L
T
M
D
P
I
K
R
I
T
S
E
Q
A
M
Q
D
P
Y
F
L
E
D
P
L
P
T
S
D
V
F
A
G
C
Q
I
P
Y
P
K
R
E
F
L
--------------------------
130
HHSearch
61.61
34%
-106
- C1 -
1J1B
1
GSK3B_HUMAN
A:
[53-352]
-------------------------------------------------------------------------------------------------------------------------------------
E
V
S
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
C
--
D
S
G
E
L
V
A
I
K
K
V
L
Q
D
-
K
R
------
F
K
N
R
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
L
R
Y
F
F
--
Y
-----
S
S
GEKKD
E
-
V
Y
L
N
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
H
Y
S
R
---
A
-----
K
-
Q
T
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
----
D
P
D
T
A
V
L
K
L
C
D
F
G
S
A
K
Q
L
V
R
-
G
-
E
P
N
V
S
Y
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
-
G
Q
P
I
F
P
G
D
S
G
-----
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
R
E
Q
I
R
E
M
--
N
P
N
Y
T
E
--
F
K
F
----
P
Q
I
-
K
-
A
H
P
----
W
T
---
K
V
F
RP
R
--
T
P
P
E
A
I
A
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
D
P
N
V
K
L
P
N
G
R
D
T
P
A
L
F
N
F
T
T
Q
E
L
S
S
N
P
P
L
A
T
I
L
I
P
P
H
A
R
I
Q
A
A
A
--
132
HHSearch
56.84
37%
-102
- C1 -
4BGQ
3
CDKL5_HUMAN
A:
[12-301]
--------------------------------------------------------------------------------------------------------------------------------------
N
K
F
E
I
L
G
V
V
G
E
G
A
Y
G
V
V
L
K
C
R
H
K
--
E
T
H
E
I
V
A
I
K
K
F
K
--------
V
K
E
T
T
L
R
E
L
K
M
L
R
T
L
K
Q
E
N
I
V
E
L
K
E
A
F
--
R
-----
R
------
R
-
G
K
L
Y
L
V
F
E
Y
V
E
K
N
M
L
E
L
L
E
---
E
---
M
-----
P
-
N
G
V
P
P
E
K
V
K
S
Y
I
Y
Q
L
I
K
A
I
H
W
C
H
K
N
D
I
V
H
R
D
I
K
P
E
N
L
L
I
----
S
-
H
N
D
V
L
K
L
C
D
F
G
F
A
R
N
L
S
E
-----------
T
R
W
Y
R
S
P
E
L
L
L
G
-
A
P
Y
G
K
S
V
D
M
W
S
V
G
C
I
L
G
E
L
S
D
-
G
Q
P
L
F
P
G
E
S
E
-----
I
D
Q
L
F
T
I
Q
K
V
L
G
P
L
P
S
E
Q
M
K
L
F
Y
S
N
P
R
F
H
G
--
L
R
F
----
P
A
V
N
H
-
P
Q
S
L
E
R
R
Y
L
---
G
----
I
--
L
N
S
V
L
L
D
L
M
K
N
L
L
K
L
D
P
A
D
R
Y
L
T
E
Q
C
L
N
H
P
T
F
Q
T
Q
R
L
---------------------------------------------
116
HHSearch
36.29
51%
7
* C1 *
4EK4
1
CDK2_HUMAN
A:
[5-291]
--------------------------------------------------------------------------------------------------------------------------------------
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
----------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
-----
T
------
E
-
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
---
A
---
S
-----
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
-
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
-
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
-----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
-----
P
K
W
-
A
-
R
Q
D
F
S
K
V
V
P
---
P
-------
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
----------------------------------------