@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : CDK17_HUMAN: (2015-10-04 )
MKKFKRRLSLTLRGSQTIDESLSELAEQMTIEENSSKDNEPIVKNGRPPTSHSMHSFLHQYTGSFKKPPLRRPHSVIGGSLGSFMAMPRNGSRLDIVHENLKMGSDGESDQASGTSSDEVQSPTGVCLRNRIHRRISMEDLNKRLSLPADIRIPDGYLEKLQINSPPFDQPMSRRSRRASLSEIGFGKMETYIKLEKLGEGTYATVYKGRSKLTENLVALKEIRLEHEEGAPCTAIREVSLLKDLKHANIVTLHDIVHTDKSLTLVFEYLDKDLKQYMDDCGNIMSMHNVKLFLYQILRGLAYCHRRKVLHRDLKPQNLLINEKGELKLADFGLARAKSVPTKTYSNEVVTLWYRPPDVLLGSSEYSTQIDMWGVGCIFFEMASGRPLFPGSTVEDELHLIFRLLGTPSQETWPGISSNEEFKNYNFPKYKPQPLINHAPRLDSEGIELITKFLQYESKKRVSAEEAMKHVYFRSLGPRIHALPESVSIFSLKEIQLQKDPGFRNSSYPETGHGKNRRQSMLF
Atome Classification :
(102 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210--.......220....-..-.-230.......240.......250.....--.-----.------260-----........270.......280-.---.-.---......290.......300.......310.......320---..-.-.....330.......--340.......350.......360.......370.......380.-.-.....390..----.....400.......410.......420----..--.--....430-.-.-------..----.-.-.440........450.......460.......470.......480.....---..490.......500-.......510.......520.
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
K
K
F
K
R
R
L
S
L
T
LRGS
Q
T
I
D
E
S
L
S
E
L
A
E
Q
MTIEENSSKDNEPIVKNGRPPT
S
H
S
M
H
S
F
L
H
Q
YTGSFKKPPLRR
P
H
S
V
IGGS
L
G
S
FMAMPRNG
S
R
L
D
I
V
H
E
NLKMGSDGESDQASGTSSDEVQS
P
T
G
V
C
L
R
N
R
I
H
R
RI
S
M
E
D
L
N
K
R
LSLP
A
D
I
RIPD
G
Y
L
E
K
L
QINSPPFD
Q
P
M
S
R
R
S
R
RA
S
L
S
EIGFG
K
M
E
T
Y
I
K
L
EKLGEG
T
Y
A
T
V
YK
G
R
S
K
--
L
T
E
N
L
V
A
L
K
E
I
R
L
E-HE-E-GAP
C
T
A
I
R
E
V
S
L
L
K
D
L
K
HA
N
I
V
T
L
H
D
I
V--H-----T------DK------
S
L
T
L
V
F
E
Y
L
D
K
D
L
K
Q
Y
M
D
D
---
C
---
G
-
N
---
I
M
S
M
H
N
V
K
L
F
L
Y
Q
I
L
R
G
L
A
Y
C
H
R
R
K
V
L
H
RDLKPQ
N
L
L
I----NE-K-G
E
L
K
L
ADFGLARAKS--VPTKTYSN
E
V
V
T
L
W
YR
P
P
D
V
L
LGSSEY
S
T
Q
ID
M
W
G
V
G
C
I
F
F
EMA-S-GRPLFPGST
V
----
E
D
E
L
H
L
I
F
R
L
LGTPSQETWPGISSNEEF----KN--Y--NFPKYKP-Q-P-------LI----N-H-APR-LDSE
G
I
E
L
I
T
K
F
L
Q
Y
E
S
KKRV
S
A
E
E
A
M
K
H
V
Y
F
R
SLG
P
R
IHALPES
V
---
S
I
F
S
L
K
E
I
Q
LQKDPG-FRNSSYPETGHGKN
R
R
QSMLF
41
PsiBlast_CBE
83.98
53%
-114
- C1 -
3RM7
2
CDK2_HUMAN
A:
[9-297]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
-----T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
-----
T
------
E
N
------
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
---
A
L
T
---
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
-
E
-
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
--
V
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
-
R
R
A
L
F
P
G
D
S
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
----
K
P
-----
S
F
P
K
W
A
R
-
Q
-
D
-------
F
S
----
K
-
V
-
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
------------------------------------------
42
PsiBlast_CBE
82.97
53%
-111
- C1 -
3RM6
2
CDK2_HUMAN
A:
[9-297]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
-
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
-----T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
-----
T
------
E
N
------
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
---
A
L
T
---
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
-
E
-
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
--
V
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
-
R
R
A
L
F
P
G
D
S
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
----
K
P
-----
S
F
P
K
W
A
R
-
Q
-
D
-------
F
S
----
K
-
V
-
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
------------------------------------------
100
PsiBlast_CBE
82.88
53%
-111
- C1 -
3QQF
2
CDK2_HUMAN
A:
[9-297]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
-----T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
-----
T
------
E
N
------
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
---
A
L
T
---
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
-
E
-
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
--
V
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
-
R
R
A
L
F
P
G
D
S
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
----
K
P
-----
S
F
P
K
W
A
R
-
Q
-
D
-------
F
S
----
K
-
V
-
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
------------------------------------------
73
PsiBlast_CBE
82.69
53%
-112
- C1 -
3R1S
2
CDK2_HUMAN
A:
[9-297]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
-----T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
-----
T
------
E
N
------
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
---
A
L
T
---
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
-
E
-
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
--
V
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
-
R
R
A
L
F
P
G
D
S
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
----
K
P
-----
S
F
P
K
W
A
R
-
Q
-
D
-------
F
S
----
K
-
V
-
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
------------------------------------------
74
PsiBlast_CBE
82.68
53%
-109
- C1 -
3R1Q
2
CDK2_HUMAN
A:
[9-297]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
-----T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
-----
T
------
E
N
------
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
---
A
L
T
---
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
-
E
-
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
--
V
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
-
R
R
A
L
F
P
G
D
S
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
----
K
P
-----
S
F
P
K
W
A
R
-
Q
-
D
-------
F
S
----
K
-
V
-
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
------------------------------------------
83
PsiBlast_CBE
82.41
53%
-112
- C1 -
3QWK
5
CDK2_HUMAN
A:
[9-297]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
-----T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
-----
T
------
E
N
------
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
---
A
L
T
---
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
-
E
-
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
--
V
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
-
R
R
A
L
F
P
G
D
S
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
----
K
P
-----
S
F
P
K
W
A
R
-
Q
-
D
-------
F
S
----
K
-
V
-
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
------------------------------------------
38
PsiBlast_CBE
82.33
53%
-109
- C1 -
3ROY
2
CDK2_HUMAN
A:
[9-297]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
-----T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
-----
T
------
E
N
------
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
---
A
L
T
---
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
-
E
-
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
--
V
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
-
R
R
A
L
F
P
G
D
S
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
----
K
P
-----
S
F
P
K
W
A
R
-
Q
-
D
-------
F
S
----
K
-
V
-
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
------------------------------------------
69
PsiBlast_CBE
82.30
53%
-110
- C1 -
3R71
2
CDK2_HUMAN
A:
[9-297]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
-----T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
-----
T
------
E
N
------
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
---
A
L
T
---
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
-
E
-
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
--
V
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
-
R
R
A
L
F
P
G
D
S
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
----
K
P
-----
S
F
P
K
W
A
R
-
Q
-
D
-------
F
S
----
K
-
V
-
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
------------------------------------------
76
PsiBlast_CBE
82.26
53%
-111
- C1 -
3QZH
2
CDK2_HUMAN
A:
[9-297]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
-----T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
-----
T
------
E
N
------
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
---
A
L
T
---
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
-
E
-
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
--
V
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
-
R
R
A
L
F
P
G
D
S
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
----
K
P
-----
S
F
P
K
W
A
R
-
Q
-
D
-------
F
S
----
K
-
V
-
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
------------------------------------------
81
PsiBlast_CBE
82.18
53%
-112
- C1 -
3QX4
3
CDK2_HUMAN
A:
[9-297]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
-----T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
-----
T
------
E
N
------
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
---
A
L
T
---
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
-
E
-
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
--
V
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
-
R
R
A
L
F
P
G
D
S
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
----
K
P
-----
S
F
P
K
W
A
R
-
Q
-
D
-------
F
S
----
K
-
V
-
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
------------------------------------------
94
PsiBlast_CBE
82.16
53%
-112
- C1 -
3QRT
3
CDK2_HUMAN
A:
[9-297]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
-----T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
-----
T
------
E
N
------
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
---
A
L
T
---
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
-
E
-
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
--
V
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
-
R
R
A
L
F
P
G
D
S
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
----
K
P
-----
S
F
P
K
W
A
R
-
Q
-
D
-------
F
S
----
K
-
V
-
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
------------------------------------------
80
PsiBlast_CBE
82.00
53%
-111
- C1 -
3QXO
2
CDK2_HUMAN
A:
[9-297]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
-----T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
-----
T
------
E
N
------
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
---
A
L
T
---
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
-
E
-
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
--
V
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
-
R
R
A
L
F
P
G
D
S
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
----
K
P
-----
S
F
P
K
W
A
R
-
Q
-
D
-------
F
S
----
K
-
V
-
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
------------------------------------------
67
PsiBlast_CBE
81.94
53%
-113
- C1 -
3R7E
2
CDK2_HUMAN
A:
[9-297]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
-----T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
-----
T
------
E
N
------
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
---
A
L
T
---
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
-
E
-
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
--
V
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
-
R
R
A
L
F
P
G
D
S
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
----
K
P
-----
S
F
P
K
W
A
R
-
Q
-
D
-------
F
S
----
K
-
V
-
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
------------------------------------------
75
PsiBlast_CBE
81.74
53%
-110
- C1 -
3QZI
2
CDK2_HUMAN
A:
[9-297]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
-----T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
-----
T
------
E
N
------
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
---
A
L
T
---
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
-
E
-
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
--
V
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
-
R
R
A
L
F
P
G
D
S
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
----
K
P
-----
S
F
P
K
W
A
R
-
Q
-
D
-------
F
S
----
K
-
V
-
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
------------------------------------------
71
PsiBlast_CBE
81.66
53%
-109
- C1 -
3R28
2
CDK2_HUMAN
A:
[9-297]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
-----T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
-----
T
------
E
N
------
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
---
A
L
T
---
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
-
E
-
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
--
V
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
-
R
R
A
L
F
P
G
D
S
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
----
K
P
-----
S
F
P
K
W
A
R
-
Q
-
D
-------
F
S
----
K
-
V
-
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
------------------------------------------
95
PsiBlast_CBE
81.63
53%
-111
- C1 -
3QQL
1
CDK2_HUMAN
A:
[9-297]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
-----T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
-----
T
------
E
N
------
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
---
A
L
T
---
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
-
E
-
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
--
V
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
-
R
R
A
L
F
P
G
D
S
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
----
K
P
-----
S
F
P
K
W
A
R
-
Q
-
D
-------
F
S
----
K
-
V
-
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
------------------------------------------
39
PsiBlast_CBE
81.49
53%
-110
- C1 -
3RNI
1
CDK2_HUMAN
A:
[9-297]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
-----T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
-----
T
------
E
N
------
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
---
A
L
T
---
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
-
E
-
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
--
V
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
-
R
R
A
L
F
P
G
D
S
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
----
K
P
-----
S
F
P
K
W
A
R
-
Q
-
D
-------
F
S
----
K
-
V
-
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
------------------------------------------
61
PsiBlast_CBE
81.48
53%
-115
- C1 -
3R8L
1
CDK2_HUMAN
A:
[9-297]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
-----T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
-----
T
------
E
N
------
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
---
A
L
T
---
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
-
E
-
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
--
V
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
-
R
R
A
L
F
P
G
D
S
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
----
K
P
-----
S
F
P
K
W
A
R
-
Q
-
D
-------
F
S
----
K
-
V
-
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
------------------------------------------
68
PsiBlast_CBE
81.34
53%
-109
- C1 -
3R73
2
CDK2_HUMAN
A:
[9-297]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
-----T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
-----
T
------
E
N
------
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
---
A
L
T
---
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
-
E
-
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
--
V
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
-
R
R
A
L
F
P
G
D
S
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
----
K
P
-----
S
F
P
K
W
A
R
-
Q
-
D
-------
F
S
----
K
-
V
-
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
------------------------------------------
77
PsiBlast_CBE
81.25
53%
-115
- C1 -
3QZG
2
CDK2_HUMAN
A:
[9-297]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
-----T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
-----
T
------
E
N
------
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
---
A
L
T
---
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
-
E
-
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
--
V
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
-
R
R
A
L
F
P
G
D
S
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
----
K
P
-----
S
F
P
K
W
A
R
-
Q
-
D
-------
F
S
----
K
-
V
-
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
------------------------------------------
78
PsiBlast_CBE
81.24
53%
-109
- C1 -
3QZF
1
CDK2_HUMAN
A:
[9-297]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
-----T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
-----
T
------
E
N
------
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
---
A
L
T
---
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
-
E
-
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
--
V
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
-
R
R
A
L
F
P
G
D
S
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
----
K
P
-----
S
F
P
K
W
A
R
-
Q
-
D
-------
F
S
----
K
-
V
-
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
------------------------------------------
37
PsiBlast_CBE
81.20
53%
-110
- C1 -
3RPO
2
CDK2_HUMAN
A:
[9-297]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
-----T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
-----
T
------
E
N
------
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
---
A
L
T
---
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
-
E
-
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
--
V
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
-
R
R
A
L
F
P
G
D
S
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
----
K
P
-----
S
F
P
K
W
A
R
-
Q
-
D
-------
F
S
----
K
-
V
-
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
------------------------------------------
46
PsiBlast_CBE
81.15
53%
-110
- C1 -
3RK5
1
CDK2_HUMAN
A:
[9-297]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
-----T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
-----
T
------
E
N
------
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
---
A
L
T
---
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
-
E
-
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
--
V
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
-
R
R
A
L
F
P
G
D
S
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
----
K
P
-----
S
F
P
K
W
A
R
-
Q
-
D
-------
F
S
----
K
-
V
-
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
------------------------------------------
72
PsiBlast_CBE
81.12
53%
-110
- C1 -
3R1Y
2
CDK2_HUMAN
A:
[9-297]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
-----T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
-----
T
------
E
N
------
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
---
A
L
T
---
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
-
E
-
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
--
V
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
-
R
R
A
L
F
P
G
D
S
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
----
K
P
-----
S
F
P
K
W
A
R
-
Q
-
D
-------
F
S
----
K
-
V
-
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
------------------------------------------
84
PsiBlast_CBE
81.09
53%
-109
- C1 -
3QWJ
2
CDK2_HUMAN
A:
[9-297]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
-----T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
-----
T
------
E
N
------
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
---
A
L
T
---
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
-
E
-
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
--
V
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
-
R
R
A
L
F
P
G
D
S
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
----
K
P
-----
S
F
P
K
W
A
R
-
Q
-
D
-------
F
S
----
K
-
V
-
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
------------------------------------------
32
PsiBlast_CBE
81.08
53%
-113
- C1 -
3S00
1
CDK2_HUMAN
A:
[9-297]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
-----T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
-----
T
------
E
N
------
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
---
A
L
T
---
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
-
E
-
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
--
V
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
-
R
R
A
L
F
P
G
D
S
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
----
K
P
-----
S
F
P
K
W
A
R
-
Q
-
D
-------
F
S
----
K
-
V
-
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
------------------------------------------
50
PsiBlast_CBE
81.07
53%
-109
- C1 -
3RAI
2
CDK2_HUMAN
A:
[9-297]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
-----T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
-----
T
------
E
N
------
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
---
A
L
T
---
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
-
E
-
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
--
V
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
-
R
R
A
L
F
P
G
D
S
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
----
K
P
-----
S
F
P
K
W
A
R
-
Q
-
D
-------
F
S
----
K
-
V
-
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
------------------------------------------
54
PsiBlast_CBE
81.06
53%
-112
- C1 -
3R9H
1
CDK2_HUMAN
A:
[9-297]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
-----T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
-----
T
------
E
N
------
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
---
A
L
T
---
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
-
E
-
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
--
V
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
-
R
R
A
L
F
P
G
D
S
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
----
K
P
-----
S
F
P
K
W
A
R
-
Q
-
D
-------
F
S
----
K
-
V
-
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
------------------------------------------
101
PsiBlast_CBE
81.04
53%
-108
- C1 -
3QL8
2
CDK2_HUMAN
A:
[9-297]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
-----T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
-----
T
------
E
N
------
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
---
A
L
T
---
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
-
E
-
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
--
V
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
-
R
R
A
L
F
P
G
D
S
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
----
K
P
-----
S
F
P
K
W
A
R
-
Q
-
D
-------
F
S
----
K
-
V
-
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
------------------------------------------
93
PsiBlast_CBE
80.97
53%
-108
- C1 -
3QRU
2
CDK2_HUMAN
A:
[9-297]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
L
----T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
-----
T
------
E
N
------
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
---
A
L
T
---
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
-
E
-
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
--
V
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
-
R
R
A
L
F
P
G
D
S
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
----
K
P
-----
S
F
P
K
W
A
R
-
Q
-
D
-------
F
S
----
K
-
V
-
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
------------------------------------------
70
PsiBlast_CBE
80.96
53%
-109
- C1 -
3R6X
2
CDK2_HUMAN
A:
[9-297]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
-----T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
-----
T
------
E
N
------
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
---
A
L
T
---
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
-
E
-
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
--
V
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
-
R
R
A
L
F
P
G
D
S
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
----
K
P
-----
S
F
P
K
W
A
R
-
Q
-
D
-------
F
S
----
K
-
V
-
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
------------------------------------------
59
PsiBlast_CBE
80.83
53%
-111
- C1 -
3R8P
1
CDK2_HUMAN
A:
[9-297]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
-----T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
-----
T
------
E
N
------
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
---
A
L
T
---
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
-
E
-
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
--
V
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
-
R
R
A
L
F
P
G
D
S
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
----
K
P
-----
S
F
P
K
W
A
R
-
Q
-
D
-------
F
S
----
K
-
V
-
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
------------------------------------------
44
PsiBlast_CBE
80.79
53%
-109
- C1 -
3RK9
1
CDK2_HUMAN
A:
[9-297]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
-----T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
-----
T
------
E
N
------
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
---
A
L
T
---
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
-
E
-
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
--
V
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
-
R
R
A
L
F
P
G
D
S
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
----
K
P
-----
S
F
P
K
W
A
R
-
Q
-
D
-------
F
S
----
K
-
V
-
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
------------------------------------------
20
PsiBlast_PDB
80.78
53%
-105
- C1 -
1OI9
1
CDK2_HUMAN
A:
[4-293]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
L
--
T
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
-----
T
------
E
N
------
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
---
A
L
T
---
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
-
E
-
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
--
V
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
-
R
R
A
L
F
P
G
D
S
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
----
K
P
-----
S
F
P
K
W
A
R
-
Q
-
D
-------
F
S
----
K
-
V
-
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
--------------------------------------------
43
PsiBlast_CBE
80.77
53%
-110
- C1 -
3RKB
2
CDK2_HUMAN
A:
[9-297]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
-----T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
-----
T
------
E
N
------
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
---
A
L
T
---
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
-
E
-
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
--
V
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
-
R
R
A
L
F
P
G
D
S
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
----
K
P
-----
S
F
P
K
W
A
R
-
Q
-
D
-------
F
S
----
K
-
V
-
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
------------------------------------------
96
PsiBlast_CBE
80.74
53%
-109
- C1 -
3QQK
6
CDK2_HUMAN
A:
[9-297]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
-----T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
-----
T
------
E
N
------
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
---
A
L
T
---
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
-
E
-
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
--
V
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
-
R
R
A
L
F
P
G
D
S
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
----
K
P
-----
S
F
P
K
W
A
R
-
Q
-
D
-------
F
S
----
K
-
V
-
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
------------------------------------------
66
PsiBlast_CBE
80.69
53%
-114
- C1 -
3R7I
2
CDK2_HUMAN
A:
[9-297]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
----------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
-----
T
------
E
N
------
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
---
A
L
T
---
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
-
E
-
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
--
V
--------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
-
R
R
A
L
F
P
G
D
S
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
----
K
P
-----
S
F
P
K
W
A
R
-
Q
-
D
-------
F
S
----
K
-
V
-
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
------------------------------------------
58
PsiBlast_CBE
80.69
53%
-110
- C1 -
3R8U
1
CDK2_HUMAN
A:
[9-297]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
-----T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
-----
T
------
E
N
------
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
---
A
L
T
---
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
-
E
-
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
--
V
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
-
R
R
A
L
F
P
G
D
S
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
----
K
P
-----
S
F
P
K
W
A
R
-
Q
-
D
-------
F
S
----
K
-
V
-
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
------------------------------------------
82
PsiBlast_CBE
80.68
53%
-110
- C1 -
3QX2
2
CDK2_HUMAN
A:
[9-297]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
-----T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
-----
T
------
E
N
------
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
---
A
L
T
---
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
-
E
-
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
--
V
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
-
R
R
A
L
F
P
G
D
S
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
----
K
P
-----
S
F
P
K
W
A
R
-
Q
-
D
-------
F
S
----
K
-
V
-
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
------------------------------------------
65
PsiBlast_CBE
80.68
53%
-114
- C1 -
3R7U
2
CDK2_HUMAN
A:
[9-297]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
----------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
-----
T
------
E
N
------
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
---
A
L
T
---
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
-
E
-
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
--
V
--------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
-
R
R
A
L
F
P
G
D
S
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
----
K
P
-----
S
F
P
K
W
A
R
-
Q
-
D
-------
F
S
----
K
-
V
-
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
------------------------------------------
92
PsiBlast_CBE
80.65
53%
-108
- C1 -
3QTQ
2
CDK2_HUMAN
A:
[9-297]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
-----T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
-----
T
------
E
N
------
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
---
A
L
T
---
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
-
E
-
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
--
V
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
-
R
R
A
L
F
P
G
D
S
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
----
K
P
-----
S
F
P
K
W
A
R
-
Q
-
D
-------
F
S
----
K
-
V
-
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
------------------------------------------
64
PsiBlast_CBE
80.59
53%
-113
- C1 -
3R7V
2
CDK2_HUMAN
A:
[9-297]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
-----T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
-----
T
------
E
N
------
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
---
A
L
T
---
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
-
E
-
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
--
V
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
-
R
R
A
L
F
P
G
D
S
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
----
K
P
-----
S
F
P
K
W
A
R
-
Q
-
D
-------
F
S
----
K
-
V
-
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
------------------------------------------
36
PsiBlast_CBE
80.52
53%
-115
- C1 -
3RPR
1
CDK2_HUMAN
A:
[9-297]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
----------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
-----
T
------
E
N
------
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
---
A
L
T
---
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
-
E
-
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
--
V
--------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
-
R
R
A
L
F
P
G
D
S
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
----
K
P
-----
S
F
P
K
W
A
R
-
Q
-
D
-------
F
S
----
K
-
V
-
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
------------------------------------------
90
PsiBlast_CBE
80.46
53%
-115
- C1 -
3QTS
1
CDK2_HUMAN
A:
[9-297]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
----------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
-----
T
------
E
N
------
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
---
A
L
T
---
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
-
E
-
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
--
V
--------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
-
R
R
A
L
F
P
G
D
S
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
----
K
P
-----
S
F
P
K
W
A
R
-
Q
-
D
-------
F
S
----
K
-
V
-
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
------------------------------------------
19
PsiBlast_PDB
80.38
53%
-102
- C1 -
1OGU
1
CDK2_HUMAN
A:
[2-293]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
G
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
L
----T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
-----
T
------
E
N
------
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
---
A
L
T
---
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
-
E
-
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
--
V
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
-
R
R
A
L
F
P
G
D
S
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
----
K
P
-----
S
F
P
K
W
A
R
-
Q
-
D
-------
F
S
----
K
-
V
-
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
-------------------------------------------
55
PsiBlast_CBE
80.35
53%
-108
- C1 -
3R9D
1
CDK2_HUMAN
A:
[9-297]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
-----T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
-----
T
------
E
N
------
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
---
A
L
T
---
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
-
E
-
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
--
V
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
-
R
R
A
L
F
P
G
D
S
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
----
K
P
-----
S
F
P
K
W
A
R
-
Q
-
D
-------
F
S
----
K
-
V
-
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
------------------------------------------
51
PsiBlast_CBE
80.35
53%
-113
- C1 -
3RAH
1
CDK2_HUMAN
A:
[9-297]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
----------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
-----
T
------
E
N
------
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
---
A
L
T
---
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
-
E
-
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
--
V
--------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
-
R
R
A
L
F
P
G
D
S
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
----
K
P
-----
S
F
P
K
W
A
R
-
Q
-
D
-------
F
S
----
K
-
V
-
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
------------------------------------------
63
PsiBlast_CBE
80.32
53%
-112
- C1 -
3R7Y
2
CDK2_HUMAN
A:
[9-297]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
-----T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
-----
T
------
E
N
------
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
---
A
L
T
---
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
-
E
-
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
--
V
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
-
R
R
A
L
F
P
G
D
S
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
----
K
P
-----
S
F
P
K
W
A
R
-
Q
-
D
-------
F
S
----
K
-
V
-
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
------------------------------------------
85
PsiBlast_CBE
80.31
53%
-111
- C1 -
3QU0
5
CDK2_HUMAN
A:
[9-297]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
-----T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
-----
T
------
E
N
------
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
---
A
L
T
---
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
-
E
-
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
--
V
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
-
R
R
A
L
F
P
G
D
S
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
----
K
P
-----
S
F
P
K
W
A
R
-
Q
-
D
-------
F
S
----
K
-
V
-
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
------------------------------------------
99
PsiBlast_CBE
80.19
53%
-110
- C1 -
3QQG
2
CDK2_HUMAN
A:
[9-297]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
-----T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
-----
T
------
E
N
------
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
---
A
L
T
---
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
-
E
-
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
--
V
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
-
R
R
A
L
F
P
G
D
S
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
----
K
P
-----
S
F
P
K
W
A
R
-
Q
-
D
-------
F
S
----
K
-
V
-
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
------------------------------------------
86
PsiBlast_CBE
80.16
53%
-109
- C1 -
3QTZ
3
CDK2_HUMAN
A:
[9-297]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
-----T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
-----
T
------
E
N
------
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
---
A
L
T
---
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
-
E
-
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
--
V
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
-
R
R
A
L
F
P
G
D
S
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
----
K
P
-----
S
F
P
K
W
A
R
-
Q
-
D
-------
F
S
----
K
-
V
-
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
------------------------------------------
57
PsiBlast_CBE
80.11
53%
-111
- C1 -
3R8V
1
CDK2_HUMAN
A:
[9-297]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
-----T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
-----
T
------
E
N
------
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
---
A
L
T
---
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
-
E
-
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
--
V
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
-
R
R
A
L
F
P
G
D
S
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
----
K
P
-----
S
F
P
K
W
A
R
-
Q
-
D
-------
F
S
----
K
-
V
-
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
------------------------------------------
53
PsiBlast_CBE
80.05
53%
-114
- C1 -
3R9N
1
CDK2_HUMAN
A:
[9-297]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
----------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
-----
T
------
E
N
------
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
---
A
L
T
---
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
-
E
-
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
--
V
--------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
-
R
R
A
L
F
P
G
D
S
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
----
K
P
-----
S
F
P
K
W
A
R
-
Q
-
D
-------
F
S
----
K
-
V
-
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
------------------------------------------
79
PsiBlast_CBE
80.02
53%
-110
- C1 -
3QXP
2
CDK2_HUMAN
A:
[9-297]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
-----T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
-----
T
------
E
N
------
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
---
A
L
T
---
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
-
E
-
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
--
V
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
-
R
R
A
L
F
P
G
D
S
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
----
K
P
-----
S
F
P
K
W
A
R
-
Q
-
D
-------
F
S
----
K
-
V
-
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
------------------------------------------
47
PsiBlast_CBE
79.99
53%
-112
- C1 -
3RJC
1
CDK2_HUMAN
A:
[9-297]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
-----T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
-----
T
------
E
N
------
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
---
A
L
T
---
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
-
E
-
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
--
V
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
-
R
R
A
L
F
P
G
D
S
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
----
K
P
-----
S
F
P
K
W
A
R
-
Q
-
D
-------
F
S
----
K
-
V
-
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
------------------------------------------
45
PsiBlast_CBE
79.92
53%
-109
- C1 -
3RK7
2
CDK2_HUMAN
A:
[9-297]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
-----T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
-----
T
------
E
N
------
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
---
A
L
T
---
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
-
E
-
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
--
V
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
-
R
R
A
L
F
P
G
D
S
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
----
K
P
-----
S
F
P
K
W
A
R
-
Q
-
D
-------
F
S
----
K
-
V
-
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
------------------------------------------
62
PsiBlast_CBE
79.78
53%
-112
- C1 -
3R83
2
CDK2_HUMAN
A:
[9-297]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
-----T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
-----
T
------
E
N
------
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
---
A
L
T
---
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
-
E
-
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
--
V
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
-
R
R
A
L
F
P
G
D
S
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
----
K
P
-----
S
F
P
K
W
A
R
-
Q
-
D
-------
F
S
----
K
-
V
-
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
------------------------------------------
88
PsiBlast_CBE
79.74
53%
-106
- C1 -
3QTW
6
CDK2_HUMAN
A:
[9-297]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
-----T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
-----
T
------
E
N
------
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
---
A
L
T
---
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
-
E
-
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
--
V
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
-
R
R
A
L
F
P
G
D
S
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
----
K
P
-----
S
F
P
K
W
A
R
-
Q
-
D
-------
F
S
----
K
-
V
-
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
------------------------------------------
35
PsiBlast_CBE
79.67
53%
-110
- C1 -
3RPV
2
CDK2_HUMAN
A:
[9-297]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
-----T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
-----
T
------
E
N
------
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
---
A
L
T
---
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
-
E
-
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
--
V
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
-
R
R
A
L
F
P
G
D
S
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
----
K
P
-----
S
F
P
K
W
A
R
-
Q
-
D
-------
F
S
----
K
-
V
-
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
------------------------------------------
31
PsiBlast_CBE
79.56
53%
-110
- C1 -
3S0O
1
CDK2_HUMAN
A:
[9-297]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
L
----T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
-----
T
------
E
N
------
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
---
A
L
T
---
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
-
E
-
G
A
I
K
L
A
D
F
--
A
R
A
F
G
--
V
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
-
R
R
A
L
F
P
G
D
S
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
----
K
P
-----
S
F
P
K
W
A
R
-
Q
-
D
-------
F
S
----
K
-
V
-
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
------------------------------------------
89
PsiBlast_CBE
79.54
53%
-109
- C1 -
3QTU
1
CDK2_HUMAN
A:
[9-297]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
-----T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
-----
T
------
E
N
------
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
---
A
L
T
---
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
-
E
-
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
--
V
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
-
R
R
A
L
F
P
G
D
S
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
----
K
P
-----
S
F
P
K
W
A
R
-
Q
-
D
-------
F
S
----
K
-
V
-
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
------------------------------------------
29
PsiBlast_CBE
79.53
53%
-111
- C1 -
3SQQ
2
CDK2_HUMAN
A:
[9-297]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
-----T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
-----
T
------
E
N
------
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
---
A
L
T
---
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
-
E
-
G
A
I
K
L
A
D
F
G
L
A
R
--------
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
-
R
R
A
L
F
P
G
D
S
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
----
K
P
-----
S
F
P
K
W
A
R
-
Q
-
D
-------
F
S
----
K
-
V
-
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
------------------------------------------
56
PsiBlast_CBE
79.35
53%
-115
- C1 -
3R8Z
1
CDK2_HUMAN
A:
[9-297]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
-----T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
-----
T
------
E
N
------
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
---
A
L
T
---
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
-
E
-
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
--
V
P
----
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
-
R
R
A
L
F
P
G
D
S
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
----
K
P
-----
S
F
P
K
W
A
R
-
Q
-
D
-------
F
S
----
K
-
V
-
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
------------------------------------------
97
PsiBlast_CBE
79.32
53%
-107
- C1 -
3QQJ
2
CDK2_HUMAN
A:
[9-297]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
-----T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
-----
T
------
E
N
------
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
---
A
L
T
---
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
-
E
-
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
--
V
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
-
R
R
A
L
F
P
G
D
S
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
----
K
P
-----
S
F
P
K
W
A
R
-
Q
-
D
-------
F
S
----
K
-
V
-
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
------------------------------------------
87
PsiBlast_CBE
79.21
53%
-110
- C1 -
3QTX
1
CDK2_HUMAN
A:
[9-297]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
-----T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
-----
T
------
E
N
------
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
---
A
L
T
---
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
-
E
-
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
--
V
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
-
R
R
A
L
F
P
G
D
S
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
----
K
P
-----
S
F
P
K
W
A
R
-
Q
-
D
-------
F
S
----
K
-
V
-
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
------------------------------------------
98
PsiBlast_CBE
78.98
53%
-110
- C1 -
3QQH
4
CDK2_HUMAN
A:
[9-297]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
-----T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
-----
T
------
E
N
------
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
---
A
L
T
---
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
-
E
-
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
--
V
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
-
R
R
A
L
F
P
G
D
S
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
----
K
P
-----
S
F
P
K
W
A
R
-
Q
-
D
-------
F
S
----
K
-
V
-
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
------------------------------------------
28
PsiBlast_CBE
78.97
53%
-110
- C1 -
4EZ3
2
CDK2_HUMAN
A:
[9-297]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
-----T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
-----
T
------
E
N
------
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
---
A
L
T
---
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
-
E
-
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
--
V
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
-
R
R
A
L
F
P
G
D
S
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
----
K
P
-----
S
F
P
K
W
A
R
-
Q
-
D
-------
F
S
----
K
-
V
-
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
------------------------------------------
91
PsiBlast_CBE
78.79
53%
-109
- C1 -
3QTR
1
CDK2_HUMAN
A:
[9-297]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
----------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
-----
T
------
E
N
------
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
---
A
L
T
---
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
-
E
-
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
--
V
--------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
-
R
R
A
L
F
P
G
D
S
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
----
K
P
-----
S
F
P
K
W
A
R
-
Q
-
D
-------
F
S
----
K
-
V
-
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
------------------------------------------
34
PsiBlast_CBE
78.73
53%
-117
- C1 -
3RPY
1
CDK2_HUMAN
A:
[9-297]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
----------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
-----
T
------
E
N
------
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
---
A
L
T
---
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
-
E
-
G
A
I
K
L
A
D
F
G
L
A
---------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
-
R
R
A
L
F
P
G
D
S
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
----
K
P
-----
S
F
P
K
W
A
R
-
Q
-
D
-------
F
S
----
K
-
V
-
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
------------------------------------------
18
PsiBlast_PDB
78.72
53%
-111
- C1 -
3EZV
1
CDK2_HUMAN
A:
[3-291]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
---------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
-----
T
------
E
N
------
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
---
A
L
T
---
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
-
E
-
G
A
I
K
L
A
D
F
G
L
----------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
-
R
R
A
L
F
P
G
D
S
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
----
K
P
-----
S
F
P
K
W
A
R
-
Q
-
D
-------
F
S
----
K
-
V
-
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
------------------------------------------
49
PsiBlast_CBE
78.59
53%
-117
- C1 -
3RAK
1
CDK2_HUMAN
A:
[9-297]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
----------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
-----
T
------
E
N
------
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
---
A
L
T
---
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
-
E
-
G
A
I
K
L
A
D
F
G
L
A
---------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
-
R
R
A
L
F
P
G
D
S
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
----
K
P
-----
S
F
P
K
W
A
R
-
Q
-
D
-------
F
S
----
K
-
V
-
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
------------------------------------------
15
PsiBlast_PDB
78.59
54%
-110
- C1 -
1V0P
1
CDC2H_PLAFK
A:
[1-285]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
K
Y
H
G
L
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
Q
N
N
--
Y
G
E
T
F
-
A
L
K
K
I
R
L
E
-
K
E
D
E
-
G
I
P
S
T
T
I
R
E
I
S
I
L
K
E
L
K
H
S
N
I
V
K
L
Y
D
V
I
--
H
-----
T
------
K
K
------
R
L
V
L
V
F
E
H
L
D
Q
D
L
K
K
L
L
D
V
---
C
---
E
-
G
---
G
L
E
S
V
T
A
K
S
F
L
L
Q
L
L
N
G
I
A
Y
C
H
D
R
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
R
-
E
-
G
E
L
K
I
A
D
F
G
L
A
R
A
F
G
-----------
I
V
T
L
W
Y
R
A
P
D
V
L
M
G
S
K
K
Y
S
T
T
I
D
I
W
S
V
G
C
I
F
A
E
M
V
-
N
-
G
T
P
L
F
P
G
V
S
E
----
A
D
Q
L
M
R
I
F
R
I
L
G
T
P
N
S
K
N
W
P
N
V
T
E
L
P
K
Y
-----
D
--
P
--
N
F
T
V
Y
E
P
-
L
-
P
-------
W
E
----
S
-
F
-
L
K
G
-
L
D
E
S
G
I
D
L
L
S
K
M
L
K
L
D
P
N
Q
R
I
T
A
K
Q
A
L
E
H
A
Y
F
K
E
----------------------------------------------------
121
HHSearch
78.55
57%
-102
- C1 -
4AU8
2
CDK5_HUMAN
A:
[6-293]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
K
Y
E
K
L
E
K
I
G
E
G
T
Y
G
T
V
F
K
A
K
N
R
--
E
T
H
E
I
V
A
L
K
R
V
-----------
P
S
S
A
L
R
E
I
C
L
L
K
E
L
K
H
K
N
I
V
R
L
H
D
V
L
--
H
--------------------
K
L
T
L
V
F
E
F
C
D
Q
D
L
K
K
Y
F
D
S
---
C
---
N
-
G
---
D
L
D
P
E
I
V
K
S
F
L
F
Q
L
L
K
G
L
G
F
C
H
S
R
N
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
R
-
N
-
G
E
L
K
L
A
D
F
G
L
A
R
A
F
G
--
I
P
V
R
--
S
A
E
V
V
T
L
W
Y
R
P
P
D
V
L
F
G
A
K
L
Y
S
T
S
I
D
M
W
S
A
G
C
I
F
A
E
L
A
-
N
A
G
R
P
L
F
P
G
N
D
V
----
D
D
Q
L
K
R
I
F
R
L
L
G
T
P
T
E
E
Q
W
P
S
M
T
K
L
P
D
Y
----
K
P
------
Y
P
M
Y
P
A
-
T
T
S
-------
L
V
----
N
-
V
-
V
P
K
-
L
N
A
T
G
R
D
L
L
Q
N
L
L
K
C
N
P
V
Q
R
I
S
A
E
E
A
L
Q
H
P
Y
F
S
D
F
---------------------------------------------------
60
PsiBlast_CBE
78.48
53%
-111
- C1 -
3R8M
1
CDK2_HUMAN
A:
[9-297]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
-----T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
-----
T
------
E
N
------
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
---
A
L
T
---
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
-
E
-
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
----------
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
-
R
R
A
L
F
P
G
D
S
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
----
K
P
-----
S
F
P
K
W
A
R
-
Q
-
D
-------
F
S
----
K
-
V
-
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
------------------------------------------
16
PsiBlast_PDB
78.44
53%
-104
- C1 -
2IW8
1
CDK2_HUMAN
A:
[4-293]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
-----
T
------
E
N
------
K
L
Y
L
V
F
E
H
V
D
Q
D
L
K
K
F
M
D
A
---
S
---
A
L
T
---
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
-
E
-
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
--
V
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
-
R
R
A
L
F
P
G
D
S
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
----
K
P
-----
S
F
P
K
W
A
R
-
Q
-
D
-------
F
S
----
K
-
V
-
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
-------------------------------------------
52
PsiBlast_CBE
78.17
53%
-109
- C1 -
3R9O
1
CDK2_HUMAN
A:
[9-297]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
----------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
-----
T
------
E
N
------
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
---
A
L
T
---
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
-
E
-
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
--
V
--------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
-
R
R
A
L
F
P
G
D
S
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
----
K
P
-----
S
F
P
K
W
A
R
-
Q
-
D
-------
F
S
----
K
-
V
-
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
------------------------------------------
30
PsiBlast_CBE
78.16
53%
-116
- C1 -
3S1H
1
CDK2_HUMAN
A:
[9-297]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
----------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
-----
T
------
E
N
------
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
---
A
L
T
---
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
-
E
-
G
A
I
K
L
A
D
F
G
L
A
---------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
-
R
R
A
L
F
P
G
D
S
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
----
K
P
-----
S
F
P
K
W
A
R
-
Q
-
D
-------
F
S
----
K
-
V
-
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
------------------------------------------
17
PsiBlast_PDB
77.83
53%
-116
- C1 -
3EZR
2
CDK2_HUMAN
A:
[3-291]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
---------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
-----
T
------
E
N
------
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
---
A
L
T
---
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
-
E
-
G
A
I
K
L
A
D
F
--------------------
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
-
R
R
A
L
F
P
G
D
S
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
----
K
P
-----
S
F
P
K
W
A
R
-
Q
-
D
-------
F
S
----
K
-
V
-
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
------------------------------------------
33
PsiBlast_CBE
77.81
53%
-112
- C1 -
3RZB
1
CDK2_HUMAN
A:
[9-297]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
----------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
-----
T
------
E
N
------
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
---
A
L
T
---
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
-
E
-
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
--
V
--------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
-
R
R
A
L
F
P
G
D
S
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
----
K
P
-----
S
F
P
K
W
A
R
-
Q
-
D
-------
F
S
----
K
-
V
-
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
------------------------------------------
26
PsiBlast_CBE
77.67
53%
-100
- C1 -
4GCJ
5
CDK2_HUMAN
A:
[9-297]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
-----
T
------
E
N
------
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
---
A
L
T
---
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
-
E
-
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
--
V
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
-
R
R
A
L
F
P
G
D
S
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
----
K
P
-----
S
F
P
K
W
A
R
-
Q
-
D
-------
F
S
----
K
-
V
-
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
------------------------------------------
11
PsiBlast_PDB
77.32
52%
-105
- C1 -
3NIZ
1
?
A:
[18-311]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
L
M
E
K
Y
Q
K
L
E
K
V
G
E
G
T
Y
G
V
V
Y
K
A
K
D
S
---
Q
G
R
I
V
A
L
K
R
I
R
--------
G
I
P
S
T
A
I
R
E
I
S
L
L
K
E
L
H
H
P
N
I
V
S
L
I
D
V
I
--
H
-----
S
------
E
R
------
C
L
T
L
V
F
E
F
M
E
K
D
L
K
K
V
L
D
E
---
N
---
K
-
T
---
G
L
Q
D
S
Q
I
K
I
Y
L
Y
Q
L
L
R
G
V
A
H
C
H
Q
H
R
I
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
S
-
D
-
G
A
L
K
L
A
D
F
G
L
A
R
A
F
G
--
I
P
V
R
---
H
E
V
V
T
L
W
Y
R
A
P
D
V
L
M
G
S
K
K
Y
S
T
S
V
D
I
W
S
I
G
C
I
F
A
E
M
I
-
T
-
G
K
P
L
F
P
G
V
T
D
----
D
D
Q
L
P
K
I
F
S
I
L
G
T
P
N
P
R
E
W
P
Q
V
Q
E
L
P
L
W
----
K
Q
--
R
--
T
F
Q
V
F
E
K
-
K
-
P
-------
W
S
----
S
-
I
-
I
P
G
-
F
C
Q
E
G
I
D
L
L
S
N
M
L
C
F
D
P
N
K
R
I
S
A
R
D
A
M
N
H
P
Y
F
K
D
L
D
P
Q
I
-----------------------------------------------
40
PsiBlast_CBE
77.17
53%
-116
- C1 -
3RMF
1
CDK2_HUMAN
A:
[9-297]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
L
---------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
-----
T
------
E
N
------
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
---
A
L
T
---
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
-
E
-
G
A
I
K
L
A
D
F
G
L
A
---------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
-
R
R
A
L
F
P
G
D
S
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
----
K
P
-----
S
F
P
K
W
A
R
-
Q
-
D
-------
F
S
----
K
-
V
-
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
------------------------------------------
48
PsiBlast_CBE
76.91
53%
-118
- C1 -
3RAL
1
CDK2_HUMAN
A:
[9-297]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
----------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
-----
T
------
E
N
------
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
---
A
L
T
---
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
-
E
-
G
A
I
K
L
A
D
F
G
L
A
---------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
-
R
R
A
L
F
P
G
D
S
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
----
K
P
-----
S
F
P
K
W
A
R
-
Q
-
D
-------
F
S
----
K
-
V
-
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
------------------------------------------
7
PsiBlast_PDB
76.83
55%
-104
- C1 -
4AU8
2
CDK5_HUMAN
A:
[6-293]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
K
Y
E
K
L
E
K
I
G
E
G
T
Y
G
T
V
F
K
A
K
N
R
--
E
T
H
E
I
V
A
L
K
R
V
-----------
P
S
S
A
L
R
E
I
C
L
L
K
E
L
K
H
K
N
I
V
R
L
H
D
V
L
--
H
--------------------
K
L
T
L
V
F
E
F
C
D
Q
D
L
K
K
Y
F
D
S
---
C
---
N
-
G
---
D
L
D
P
E
I
V
K
S
F
L
F
Q
L
L
K
G
L
G
F
C
H
S
R
N
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
R
-
N
-
G
E
L
K
L
A
D
F
G
L
A
R
A
F
G
--
I
P
V
R
--
S
A
E
V
V
T
L
W
Y
R
P
P
D
V
L
F
G
A
K
L
Y
S
T
S
I
D
M
W
S
A
G
C
I
F
A
E
L
A
N
A
-
G
R
P
L
F
P
G
N
D
V
----
D
D
Q
L
K
R
I
F
R
L
L
G
T
P
T
E
E
Q
W
P
S
M
T
K
----------------
L
P
D
Y
K
P
-
Y
-
P
MYPATTS
L
V
----
N
-
V
-
V
P
K
-
L
N
A
T
G
R
D
L
L
Q
N
L
L
K
C
N
P
V
Q
R
I
S
A
E
E
A
L
Q
H
P
Y
F
S
D
F
---------------------------------------------------
25
PsiBlast_CBE
76.67
54%
-118
- C1 -
1V0P
1
CDC2H_PLAFK
B:
[2-285]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
K
Y
H
G
L
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
Q
N
N
--
Y
G
E
T
F
-
A
L
K
-------------
P
S
T
T
I
R
E
I
S
I
L
K
E
L
K
H
S
N
I
V
K
L
Y
D
V
I
--
H
-----
T
---------------
L
V
L
V
F
E
H
L
D
Q
D
L
K
K
L
L
D
V
---
C
---
E
-
G
---
G
L
E
S
V
T
A
K
S
F
L
L
Q
L
L
N
G
I
A
Y
C
H
D
R
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
R
-
E
-
G
E
L
K
I
A
D
F
G
L
A
R
A
F
---------------
L
W
Y
R
A
P
D
V
L
M
G
S
K
K
Y
S
T
T
I
D
I
W
S
V
G
C
I
F
A
E
M
V
-
N
-
G
T
P
L
F
P
G
V
S
E
----
A
D
Q
L
M
R
I
F
R
I
L
G
T
P
N
S
K
N
W
P
N
V
T
E
L
P
K
Y
-----
D
--
P
--
N
F
T
V
Y
E
P
-
L
-
P
-------
W
E
----
S
-
F
-
L
K
G
-
L
D
E
S
G
I
D
L
L
S
K
M
L
K
L
D
P
N
Q
R
I
T
A
K
Q
A
L
E
H
A
Y
F
K
E
----------------------------------------------------
27
PsiBlast_CBE
76.52
53%
-101
- C1 -
4EZ7
7
CDK2_HUMAN
A:
[9-297]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
-----
T
------
E
N
------
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
---
A
L
T
---
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
-
E
-
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
--
V
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
-
R
R
A
L
F
P
G
D
S
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
----
K
P
-----
S
F
P
K
W
A
R
-
Q
-
D
-------
F
S
----
K
-
V
-
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
------------------------------------------
127
HHSearch
76.47
52%
-104
- C1 -
3NIZ
1
?
A:
[15-310]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
F
Q
G
L
M
E
K
Y
Q
K
L
E
K
V
G
E
G
T
Y
G
V
V
Y
K
A
K
D
---
S
Q
G
R
I
V
A
L
K
R
I
R
--------
G
I
P
S
T
A
I
R
E
I
S
L
L
K
E
L
H
H
P
N
I
V
S
L
I
D
V
I
--
H
-----
S
------
E
R
------
C
L
T
L
V
F
E
F
M
E
K
D
L
K
K
V
L
D
E
---
N
---
K
-
T
---
G
L
Q
D
S
Q
I
K
I
Y
L
Y
Q
L
L
R
G
V
A
H
C
H
Q
H
R
I
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
S
-
D
-
G
A
L
K
L
A
D
F
G
L
A
R
A
F
G
--
I
P
V
R
---
H
E
V
V
T
L
W
Y
R
A
P
D
V
L
M
G
S
K
K
Y
S
T
S
V
D
I
W
S
I
G
C
I
F
A
E
M
I
-
T
-
G
K
P
L
F
P
G
V
T
D
----
D
D
Q
L
P
K
I
F
S
I
L
G
T
P
N
P
R
E
W
P
Q
V
Q
E
L
P
L
W
----
K
Q
--
R
--
T
F
Q
V
F
E
K
-
K
-
P
-------
W
S
----
S
-
I
-
I
P
G
-
F
C
Q
E
G
I
D
L
L
S
N
M
L
C
F
D
P
N
K
R
I
S
A
R
D
A
M
N
H
P
Y
F
K
D
L
D
P
Q
I
-----------------------------------------------
3
PsiBlast_PDB
75.44
55%
-108
- C1 -
1UNG
1
CDK5_HUMAN
A:
[1-291]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
Q
K
Y
E
K
L
E
K
I
----
Y
G
T
V
F
K
A
K
N
R
--
E
T
H
E
I
V
A
L
K
R
V
R
L
D
-
D
D
D
E
-
G
V
P
S
S
A
L
R
E
I
C
L
L
K
E
L
K
H
K
N
I
V
R
L
H
D
V
L
--
H
-----
S
------
D
K
------
K
L
T
L
V
F
E
F
C
D
Q
D
L
K
K
Y
F
D
S
---
C
---
N
-
G
---
D
L
D
P
E
I
V
K
S
F
L
F
Q
L
L
K
G
L
G
F
C
H
S
R
N
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
R
-
N
-
G
E
L
K
L
A
N
F
G
L
A
R
A
F
G
--
I
P
V
R
C
Y
S
A
E
V
V
T
L
W
Y
R
P
P
D
V
L
F
G
A
K
L
Y
S
T
S
I
D
M
W
S
A
G
C
I
F
A
E
L
A
N
A
-
G
R
P
L
F
P
G
N
D
V
----
D
D
Q
L
K
R
I
F
R
L
L
G
T
P
T
E
E
Q
W
P
S
M
T
K
----------------
L
P
D
Y
K
P
-
Y
-
P
MYPATTS
L
V
----
N
-
V
-
V
P
K
-
L
N
A
T
G
R
D
L
L
Q
N
L
L
K
C
N
P
V
Q
R
I
S
A
E
E
A
L
Q
H
P
Y
F
S
D
F
C
P
P
------------------------------------------------
5
PsiBlast_PDB
75.26
55%
-104
- C1 -
1UNL
1
CDK5_HUMAN
A:
[1-291]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
Q
K
Y
E
K
L
E
K
I
G
E
G
T
Y
G
T
V
F
K
A
K
N
R
--
E
T
H
E
I
V
A
L
K
R
V
R
L
D
-
D
D
D
E
-
G
V
P
S
S
A
L
R
E
I
C
L
L
K
E
L
K
H
K
N
I
V
R
L
H
D
V
L
--
H
-----
S
------
D
K
------
K
L
T
L
V
F
E
F
C
D
Q
D
L
K
K
Y
F
D
S
---
C
---
N
-
G
---
D
L
D
P
E
I
V
K
S
F
L
F
Q
L
L
K
G
L
G
F
C
H
S
R
N
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
R
-
N
-
G
E
L
K
L
A
N
F
G
L
A
R
A
F
G
--
I
P
V
R
C
Y
S
A
E
V
V
T
L
W
Y
R
P
P
D
V
L
F
G
A
K
L
Y
S
T
S
I
D
M
W
S
A
G
C
I
F
A
E
L
A
N
A
-
G
R
P
L
F
P
G
N
D
V
----
D
D
Q
L
K
R
I
F
R
L
L
G
T
P
T
E
E
Q
W
P
S
M
T
K
----------------
L
P
D
Y
K
P
-
Y
-
P
MYPATTS
L
V
----
N
-
V
-
V
P
K
-
L
N
A
T
G
R
D
L
L
Q
N
L
L
K
C
N
P
V
Q
R
I
S
A
E
E
A
L
Q
H
P
Y
F
S
D
F
C
P
P
------------------------------------------------
24
PsiBlast_CBE
75.22
54%
-105
- C1 -
1V0O
1
CDC2H_PLAFK
B:
[3-285]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
Y
H
G
L
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
Q
N
N
--
Y
G
E
T
F
-
A
L
K
K
I
R
L
------------
T
I
R
E
I
S
I
L
K
E
L
K
H
S
N
I
V
K
L
Y
D
V
I
--
H
-----
T
------
K
K
------
R
L
V
L
V
F
E
H
L
D
Q
D
L
K
K
L
L
D
V
---
C
---
E
-
G
---
G
L
E
S
V
T
A
K
S
F
L
L
Q
L
L
N
G
I
A
Y
C
H
D
R
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
R
-
E
-
G
E
L
K
I
A
D
F
G
L
A
R
A
F
G
--
I
P
V
R
K
Y
T
H
E
V
V
T
L
W
Y
R
A
P
D
V
L
M
G
S
K
K
Y
S
T
T
I
D
I
W
S
V
G
C
I
F
A
E
M
V
-
N
-
G
T
P
L
F
P
G
V
S
E
----
A
D
Q
L
M
R
I
F
R
I
L
G
T
P
N
S
K
N
W
P
N
V
T
E
L
P
K
Y
-----
D
--
P
--
N
F
T
V
Y
E
P
-
L
-
P
-------
W
E
----
S
-
F
-
L
K
G
-
L
D
E
S
G
I
D
L
L
S
K
M
L
K
L
D
P
N
Q
R
I
T
A
K
Q
A
L
E
H
A
Y
F
K
E
N
---------------------------------------------------
23
PsiBlast_CBE
75.10
55%
-109
- C1 -
4AU8
2
CDK5_HUMAN
B:
[6-293]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
K
Y
E
K
L
E
K
I
G
E
G
T
Y
G
T
V
F
K
A
K
N
R
--
E
T
H
E
I
V
A
L
K
R
V
R
L
-----
E
-
G
V
P
S
S
A
L
R
E
I
C
L
L
K
E
L
K
H
K
N
I
V
R
L
H
D
V
L
--
H
-----
S
-------
K
------
K
L
T
L
V
F
E
F
C
D
Q
D
L
K
K
Y
F
D
S
---
C
---
N
-
G
---
D
L
D
P
E
I
V
K
S
F
L
F
Q
L
L
K
G
L
G
F
C
H
S
R
N
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
R
-
N
-
G
E
L
K
L
A
D
F
G
L
A
R
A
F
G
--
I
P
V
------
V
V
T
L
W
Y
R
P
P
D
V
L
F
G
A
K
L
Y
S
T
S
I
D
M
W
S
A
G
C
I
F
A
E
L
A
N
A
-
G
R
P
L
F
P
G
N
D
V
----
D
D
Q
L
K
R
I
F
R
L
L
G
T
P
T
E
E
Q
W
P
S
M
T
K
----------------
L
P
D
Y
K
P
-
Y
-
P
M
Y
P
A
T
TS
L
V
----
N
-
V
-
V
P
K
-
L
N
A
T
G
R
D
L
L
Q
N
L
L
K
C
N
P
V
Q
R
I
S
A
E
E
A
L
Q
H
P
Y
F
S
D
F
---------------------------------------------------
13
PsiBlast_PDB
74.71
54%
-108
- C1 -
1V0O
1
CDC2H_PLAFK
A:
[3-285]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
Y
H
G
L
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
Q
N
N
--
Y
G
E
T
F
-
A
L
K
K
I
R
L
----------
S
T
T
I
R
E
I
S
I
L
K
E
L
K
H
S
N
I
V
K
L
Y
D
V
I
--
H
-----
T
------
K
K
------
R
L
V
L
V
F
E
H
L
D
Q
D
L
K
K
L
L
D
V
---
C
---
E
-
G
---
G
L
E
S
V
T
A
K
S
F
L
L
Q
L
L
N
G
I
A
Y
C
H
D
R
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
R
-
E
-
G
E
L
K
I
A
D
F
G
L
A
R
A
F
G
--
I
P
V
R
K
Y
T
H
E
V
V
T
L
W
Y
R
A
P
D
V
L
M
G
S
K
K
Y
S
T
T
I
D
I
W
S
V
G
C
I
F
A
E
M
V
-
N
-
G
T
P
L
F
P
G
V
S
E
----
A
D
Q
L
M
R
I
F
R
I
L
G
T
P
N
S
K
N
W
P
N
V
T
E
L
P
K
Y
-----
D
--
P
--
N
F
T
V
Y
E
P
-
L
-
P
-------
W
E
----
S
-
F
-
L
K
G
-
L
D
E
S
G
I
D
L
L
S
K
M
L
K
L
D
P
N
Q
R
I
T
A
K
Q
A
L
E
H
A
Y
F
K
E
N
---------------------------------------------------
21
PsiBlast_CBE
72.54
55%
-110
- C1 -
3O0G
1
CDK5_HUMAN
B:
[6-288]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
E
K
I
G
-----
T
V
F
K
A
--------
E
I
V
A
L
K
R
V
R
----------
P
S
S
A
L
R
E
I
C
L
L
K
E
L
K
H
K
N
I
V
R
L
H
D
V
L
--
H
-----
S
------
D
K
------
K
L
T
L
V
F
E
F
C
D
Q
D
L
K
K
Y
F
D
S
---
C
---
N
-
G
---
D
L
D
P
E
I
V
K
S
F
L
F
Q
L
L
K
G
L
G
F
C
H
S
R
N
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
R
-
N
-
G
E
L
K
L
A
N
F
G
L
A
R
A
F
G
--
I
P
V
R
C
Y
S
A
E
V
V
T
L
W
Y
R
P
P
D
V
L
F
G
A
K
L
Y
S
T
S
I
D
M
W
S
A
G
C
I
F
A
E
L
A
N
A
-
G
R
P
L
F
P
G
N
D
V
----
D
D
Q
L
K
R
I
F
R
L
L
G
T
P
T
E
E
Q
W
P
S
M
T
K
----------------
L
P
D
Y
K
P
-
Y
-
P
MYPATTS
L
V
----
N
-
V
-
V
P
K
-
L
N
A
T
G
R
D
L
L
Q
N
L
L
K
C
N
P
V
Q
R
I
S
A
E
E
A
L
Q
H
P
Y
F
S
D
----------------------------------------------------
8
PsiBlast_PDB
72.50
54%
-100
- C1 -
4Y72
1
?
A:
[3-294]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
S
M
E
D
Y
T
K
I
E
K
I
G
E
G
T
Y
G
V
V
Y
K
G
R
H
K
--
T
T
G
Q
V
V
A
M
K
K
I
R
L
E
S
E
E
-
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
R
H
P
N
I
V
S
L
Q
D
V
L
--
M
-----
Q
------
D
S
------
R
L
Y
L
I
F
E
F
L
S
M
D
L
K
K
Y
L
D
S
---
I
PP-
G
-
Q
---
Y
M
D
S
S
L
V
K
S
Y
L
Y
Q
I
L
Q
G
I
V
F
C
H
S
R
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
D
D
-
K
-
G
T
I
K
L
A
D
F
G
L
A
R
A
F
G
--
I
P
I
R
V
Y
T
H
E
V
V
T
L
W
Y
R
S
P
E
V
L
L
G
S
A
R
Y
S
T
P
V
D
I
W
S
I
G
T
I
F
A
E
L
A
-
T
-
K
K
P
L
F
H
G
D
S
E
----
I
D
Q
L
F
R
I
F
R
A
L
G
T
P
N
N
E
V
W
P
E
V
E
S
L
Q
D
Y
----
K
N
-----
T
F
P
K
W
K
P
-
G
-
S
-------
L
A
----
S
-
H
-
V
K
N
-
L
D
E
N
G
L
D
L
L
S
K
M
L
I
Y
D
P
A
K
R
I
S
G
K
M
A
L
N
H
P
Y
F
N
D
----------------------------------------------------
126
HHSearch
66.86
31%
-96
- C1 -
1J1B
1
GSK3B_HUMAN
A:
[55-372]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
C
--
D
S
G
E
L
V
A
I
K
K
V
L
Q
D
-
K
-------
R
F
K
N
R
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
L
R
Y
F
F
--
Y
-----
S
S
GEKKD
E
V
------
Y
L
N
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
H
---
Y
S
R
A
K
-
Q
---
T
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
----
D
P
-
D
T
A
V
L
K
L
C
D
F
G
S
A
K
Q
L
V
RG
E
P
N
V
S
---
Y
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
-
L
-
G
Q
P
I
F
P
G
D
S
G
----
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
R
E
Q
I
R
E
M
N
--
P
N
Y
----
T
E
--
F
--
K
F
P
Q
I
K
A
-
H
-
P
-------
W
T
----
K
-
V
F
R
P
R
-
T
P
P
E
A
I
A
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
D
P
N
V
K
L
P
N
G
R
DTP
A
L
F
N
F
T
T
Q
E
L
S
S
N
P
P
-
L
A
T
I
L
I
P
P
H
A
R
I
Q
A
A
A
-----
113
HHSearch
66.28
32%
-91
- C1 -
3EB0
3
?
A:
[7-375]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
K
Y
S
L
G
K
T
L
G
T
G
-
F
G
I
V
C
E
V
F
D
I
--
E
S
G
K
R
F
A
L
K
K
V
L
Q
D
--------
P
R
Y
K
N
R
E
L
D
I
M
K
V
L
D
H
V
N
I
I
K
L
V
D
Y
F
--
Y
-----
T
T-----
N
K
------
Y
L
N
V
I
M
E
Y
V
P
D
T
L
H
K
V
L
K
S
F
I
R
S
---
G
-
R
---
S
I
P
M
N
L
I
S
I
Y
I
Y
Q
L
F
R
A
V
G
F
I
H
S
L
G
I
C
H
R
D
I
K
P
Q
N
L
L
V
----
N
S
K
D
-
N
T
L
K
L
C
D
F
G
S
A
K
K
L
I
---
P
S
E
P
S
V
A
Y
I
C
S
R
F
Y
R
A
P
E
L
M
L
G
A
T
E
Y
T
P
S
I
D
L
W
S
I
G
C
V
F
G
E
L
I
-
L
-
G
K
P
L
F
S
G
E
T
S
----
I
D
Q
L
V
R
I
I
Q
I
M
G
T
P
T
K
E
Q
M
I
R
M
N
--
P
H
Y
--------
V
--
R
F
P
T
L
K
A
-
K
-
D
-------
W
R
----
K
-
I
-
L
P
E
G
T
P
S
L
A
I
D
L
L
E
Q
I
L
R
Y
E
P
D
L
R
I
N
P
Y
E
A
M
A
H
P
F
F
D
H
L
R
N
S
--------IP-
Q
L
F
N
F
S
P
Y
E
L
S
I
I
P
G
N
V
L
N
R
I
L
P
K
-------------
130
HHSearch
66.21
34%
-98
- C1 -
2B9H
1
FUS3_YEAST
A:
[5-314]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
Y
N
I
S
S
D
F
Q
L
K
S
L
L
G
E
G
A
Y
G
V
V
C
S
A
T
H
K
--
P
T
G
E
I
V
A
I
K
K
I
E
P
F
-
D
K
-
P
-
L
F
A
L
R
T
L
R
E
I
K
I
L
K
H
F
K
H
E
N
I
I
T
I
F
N
I
Q
--
R
PDSFE
N
------
F
N
------
E
V
Y
I
I
Q
E
L
M
Q
T
D
L
H
R
V
I
S
T
---------
Q
---
M
L
S
D
D
H
I
Q
Y
F
I
Y
Q
T
L
R
A
V
K
V
L
H
G
S
N
V
I
H
R
D
L
K
P
S
N
L
L
I
----
N
S
-
N
-
C
D
L
K
V
C
D
F
G
L
A
R
I
I
D
--------
V
E
F
V
A
T
R
W
Y
R
A
P
E
V
M
L
T
S
A
K
Y
S
R
A
M
D
V
W
S
C
G
C
I
L
A
E
L
F
-
L
-
R
R
P
I
F
P
G
R
D
Y
----
R
H
Q
L
L
L
I
F
G
I
I
G
T
P
H
S
D
N
D
L
R
C
I
E
S
P
R
A
----
R
E
Y
I
K
--
S
L
P
M
Y
P
A
-
A
-
P
-------
L
E
----
K
-
M
-
F
P
R
-
V
N
P
K
G
I
D
L
L
Q
R
M
L
V
F
D
P
A
K
R
I
T
A
K
E
A
L
E
H
P
Y
L
Q
T
Y
H
D
P
N
D
E
P
E
G
E
P
---
I
P
P
S
F
F
E
F
D
H
Y
K
E
A
L
-
T
T
K
D
L
K
K
L
I
W
N
E
I
F
S
------
115
HHSearch
61.34
39%
-94
- C1 -
1UA2
1
CDK7_HUMAN
A:
[13-298]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
K
L
D
F
L
G
E
G
Q
F
A
T
V
Y
K
A
R
D
K
--
N
T
N
Q
I
V
A
I
K
K
I
-----------
N
R
T
A
L
R
E
I
K
L
L
Q
E
L
S
H
P
N
I
I
G
L
L
D
A
F
--
G
-----
H
------
K
S
------
N
I
S
L
V
F
D
F
M
E
T
D
L
E
V
I
I
K
D
---
N
---
S
-
L
---
V
L
T
P
S
H
I
K
A
Y
M
L
M
T
L
Q
G
L
E
Y
L
H
Q
H
W
I
L
H
R
D
L
K
P
N
N
L
L
L
----
D
E
-
N
-
G
V
L
K
L
A
D
F
G
L
A
K
S
F
G
--
S
P
N
R
A
Y
T
H
Q
V
V
T
R
W
Y
R
A
P
E
L
L
F
G
A
R
M
Y
G
V
G
V
D
M
W
A
V
G
C
I
L
A
E
L
L
-
L
-
R
V
P
F
L
P
G
D
S
D
----
L
D
Q
L
T
R
I
F
E
T
L
G
T
P
T
E
E
Q
W
P
D
M
C
S
L
P
D
Y
----
V
------
T
F
K
S
F
P
G
-
I
-
P
-------
L
H
----
H
-
I
-
F
S
A
-
A
G
D
D
L
L
D
L
I
Q
G
L
F
L
F
N
P
C
A
R
I
T
A
T
Q
A
L
K
M
K
Y
F
S
N
R
P
G
P
T
P
G
C
Q
L
P
R
---
P
N
-----------------------------------
132
HHSearch
60.23
39%
-107
- C1 -
4F6U
10
CDK8_HUMAN
A:
[27-340]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
C
K
V
G
R
G
T
Y
G
H
V
Y
K
A
K
R
K
DG
K
D
D
K
D
Y
A
L
K
Q
I
E
G
-----
T
-
G
I
S
M
S
A
C
R
E
I
A
L
L
R
E
L
K
H
P
N
V
I
S
L
Q
K
V
F
L
S
H
-----
A
------
D
R
------
K
V
W
L
L
F
D
Y
A
E
H
D
L
W
H
I
I
K
F
---
H
---
R
-
A
S
KV
Q
L
P
R
G
M
V
K
S
L
L
Y
Q
I
L
D
G
I
H
Y
L
H
A
N
W
V
L
H
R
D
L
K
P
A
N
I
L
V
M
G
EG
P
E
-
R
-
G
R
V
K
I
A
D
M
G
F
----------------
V
V
T
F
W
Y
R
A
P
E
L
L
L
G
A
R
H
Y
T
K
A
I
D
I
W
A
I
G
C
I
F
A
E
L
L
-
T
-
S
E
P
I
F
H
C
R
Q
E
NPYH
H
D
Q
L
D
R
I
F
N
V
M
G
F
P
A
D
K
D
W
E
D
I
K
K
M
P
E
H
S
T
L
M
K
D
--
F
--
R
R
N
T
Y
T
N
-
C
-
S
-------
L
I
K
Y
M
E
K
-
H
-
K
V
K
-
P
D
S
K
A
F
H
L
L
Q
K
L
L
T
M
D
P
I
K
R
I
T
S
E
Q
A
M
Q
D
P
Y
F
L
E
D
P
L
P
T
S
D
V
F
A
G
C
---
Q
I
P
Y
P
K
R
E
F
L
---------------------------
133
HHSearch
59.27
37%
-102
- C1 -
4BGQ
3
CDKL5_HUMAN
A:
[11-300]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
N
K
F
E
I
L
G
V
V
G
E
G
A
Y
G
V
V
L
K
C
R
H
K
--
E
T
H
E
I
V
A
I
K
K
F
K
---------
V
K
E
T
T
L
R
E
L
K
M
L
R
T
L
K
Q
E
N
I
V
E
L
K
E
A
F
--
R
-----
R
------
R
G
------
K
L
Y
L
V
F
E
Y
V
E
K
N
M
L
E
L
L
E
E
---
M
---
P
-
N
---
G
V
P
P
E
K
V
K
S
Y
I
Y
Q
L
I
K
A
I
H
W
C
H
K
N
D
I
V
H
R
D
I
K
P
E
N
L
L
I
----
S
H
-
N
-
D
V
L
K
L
C
D
F
G
F
A
R
N
L
S
--
E
----------
T
R
W
Y
R
S
P
E
L
L
L
G
-
A
P
Y
G
K
S
V
D
M
W
S
V
G
C
I
L
G
E
L
S
-
D
-
G
Q
P
L
F
P
G
E
S
E
----
I
D
Q
L
F
T
I
Q
K
V
L
G
P
L
P
S
E
Q
M
K
L
F
Y
S
N
P
R
F
----
H
G
--
L
--
R
F
P
A
V
N
H
P
Q
-
S
-------
L
E
----
R
R
Y
-
L
G
I
-
L
N
S
V
L
L
D
L
M
K
N
L
L
K
L
D
P
A
D
R
Y
L
T
E
Q
C
L
N
H
P
T
F
Q
T
Q
R
L
-------------------------------------------------
131
HHSearch
58.09
36%
-109
- C1 -
2FST
3
MK14_HUMAN
X:
[25-320]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
V
P
E
R
Y
Q
N
L
S
P
V
G
----
G
S
V
C
A
A
F
D
T
--
K
T
G
L
R
V
A
V
K
K
L
S
R
P
-
F
Q
-
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
--
T
-----
P
------
A
R
SLEEFN
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
--------------
Q
---
K
L
T
D
D
H
V
Q
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
----
N
E
-
D
-
C
E
L
K
I
L
D
--------------------
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
-
T
-
G
R
T
L
F
P
G
T
D
H
----
I
D
Q
L
K
L
I
L
R
L
V
G
T
P
G
A
E
L
L
K
K
I
S
S
E
S
-
A
----
R
N
--
Y
IQ
S
L
T
Q
M
P
K
-
M
-
N
-------
F
A
----
N
-
V
-
F
I
G
-
A
N
P
L
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
P
V
A
D
P
---
Y
D
Q
S
L
E
S
R
D
L
L
I
D
E
W
-
K
S
L
T
Y
D
E
V
I
S
F
V
P
P
P
------
119
HHSearch
45.01
54%
22
* C1 *
4EK4
1
CDK2_HUMAN
A:
[4-291]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
-----------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
-----
T
------
E
N
------
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
---
A
-
L
T--
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
-
E
-
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
--
V
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
-
R
R
A
L
F
P
G
D
S
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
----
K
P
-----
S
F
P
K
W
A
R
-
Q
-
D
-------
F
S
----
K
-
V
-
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
--------------------------------------------