@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : CDK18_HUMAN: (2015-10-04 )
MNKMKNFKRRFSLSVPRTETIEESLAEFTEQFNQLHNRRNENLQLGPLGRDPPQECSTFSPTDSGEEPGQLSPGVQFQRRQNQRRFSMEDVSKRLSLPMDIRLPQEFLQKLQMESPDLPKPLSRMSRRASLSDIGFGKLETYVKLDKLGEGTYATVFKGRSKLTENLVALKEIRLEHEEGAPCTAIREVSLLKNLKHANIVTLHDLIHTDRSLTLVFEYLDSDLKQYLDHCGNLMSMHNVKIFMFQLLRGLAYCHHRKILHRDLKPQNLLINERGELKLADFGLARAKSVPTKTYSNEVVTLWYRPPDVLLGSTEYSTPIDMWGVGCIHYEMATGRPLFPGSTVKEELHLIFRLLGTPTEETWPGVTAFSEFRTYSFPCYLPQPLINHAPRLDTDGIHLLSSLLLYESKSRMSAEAALSHSYFRSLGERVHQLEDTASIFSLKEIQLQKDPGYRGLAFQQPGRGKNRRQSIF
Atome Classification :
(99 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160--.......170....-..-.-180.......190.......200.....--.-----.------210-----........220.......230-.---.-.---......240.......250.......260.......270---..-.-.....280.......--290.......300.......310.......320.......330.-.-.....340..----.....350.......360.......370.----..--....380-..-..----...-.-390........400.......410.......420.......430....-.---..440.......450-.......460.......470
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
N
K
M
K
N
F
K
R
R
FSLSVP
R
T
E
T
I
E
E
S
L
A
E
F
T
E
Q
F
N
Q
L
H
NRRNENLQLGPLGRD
P
P
Q
ECSTFSPTDSGEEPGQLSPG
V
Q
F
Q
R
R
QNQRRF
S
M
E
D
V
S
K
R
LSLPMDIR
L
P
Q
E
F
L
Q
K
L
QMESPDLP
K
P
L
S
R
M
S
R
RASLSDIG
F
G
K
L
E
T
Y
V
K
L
DKLGEGT
Y
A
T
V
FK
G
R
S
K
--
L
T
E
N
L
V
A
L
K
E
I
R
L
E-HE-E-GAP
C
T
A
I
R
E
V
S
L
L
K
NLKHA
N
I
V
T
L
H
D
L
I--H-----T------DR------
S
L
T
L
V
F
E
Y
L
D
S
D
L
K
Q
Y
L
D
H---C---
G
-
N
---
L
M
S
M
H
N
V
K
I
F
M
F
Q
L
L
R
G
L
A
Y
C
H
H
R
K
I
L
H
RDLKPQ
N
L
L
I----NE-R-G
E
L
K
L
A
DFGLARAKS--VPTKTYSN
E
V
V
T
L
W
YR
P
P
D
V
L
LGSTEYSTPID
M
W
G
V
G
C
I
H
Y
EMA-T-GRPLFPG
S
T
V
----
K
E
E
L
H
L
I
F
R
L
LGTPTEETWPG
V
T
A
F
S
EFR----TY--SFPCY-L-
P
Q
-
P
L
----
I
NH-A-PR-LDT
D
G
I
H
L
L
S
S
L
L
L
Y
ESKSRM
S
A
E
A
A
L
S
H
S
Y
F
R
S
L
G
E
R
V
H
Q
L
E
D
T
-
A
---
S
I
F
S
L
K
E
I
Q
L
QKDPG-YRGLAFQQPGRGKNRRQSIF
13
PsiBlast_PDB
86.49
53%
-101
- C1 -
1OGU
1
CDK2_HUMAN
A:
[2-300]
---------------------------------------------------------------------------------------------------------------------------------------
P
G
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
L
----T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
-----
T
------
E
N
------
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
---
A
L
T
---
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
-
E
-
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
--
V
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
-
R
R
A
L
F
P
G
D
S
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
----
P
---
S
F
P
K
W
-
A
-
R
Q
-
D
F
----
S
K
V
-
V
-
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
-------------------------------------------
82
PsiBlast_CBE
86.48
53%
-111
- C1 -
2VTS
1
CDK2_HUMAN
A:
[1-296]
------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
----------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
-----
T
------
E
N
------
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
---
A
L
T
---
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
-
E
-
G
A
I
K
L
A
D
F
G
L
A
R
A
F
----------
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
-
R
R
A
L
F
P
G
D
S
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
----
P
---
S
F
P
K
W
-
A
-
R
Q
-
D
F
----
S
K
V
-
V
-
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
------------------------------------------
25
PsiBlast_CBE
86.28
53%
-109
- C1 -
5A14
2
?
A:
[2-297]
------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
L
D
---T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
-----
T
------
E
N
------
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
---
A
L
T
---
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
-
E
-
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
-
R
R
A
L
F
P
G
D
S
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
----
P
---
S
F
P
K
W
-
A
-
R
Q
-
D
F
----
S
K
V
-
V
-
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
--------------------------------------------
46
PsiBlast_CBE
85.97
53%
-110
- C1 -
3WBL
1
CDK2_HUMAN
A:
[1-296]
------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
---
T
G
E
V
V
A
L
K
K
I
R
L
-------
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
-----
T
------
E
N
------
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
---
A
L
T
---
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
-
E
-
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-----------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
-
R
R
A
L
F
P
G
D
S
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
----
P
---
S
F
P
K
W
-
A
-
R
Q
-
D
F
----
S
K
V
-
V
-
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
------------------------------------------
96
PsiBlast_CBE
85.88
53%
-113
- C1 -
2UZN
1
CDK2_HUMAN
A:
[1-296]
------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
-----------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
-----
T
------
E
N
------
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
---
A
L
T
---
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
-
E
-
G
A
I
K
L
A
D
F
G
L
A
R
A
F
------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
-
R
R
A
L
F
P
G
D
S
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
----
P
---
S
F
P
K
W
-
A
-
R
Q
-
D
F
----
S
K
V
-
V
-
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
------------------------------------------
123
HHSearch
85.86
57%
-108
- C1 -
4AU8
2
CDK5_HUMAN
A:
[6-293]
-------------------------------------------------------------------------------------------------------------------------------------------
Q
K
Y
E
K
L
E
K
I
G
E
G
T
Y
G
T
V
F
K
A
K
N
R
--
E
T
H
E
I
V
A
L
K
R
V
-----------
P
S
S
A
L
R
E
I
C
L
L
K
E
L
K
H
K
N
I
V
R
L
H
D
V
L
--
H
--------------------
K
L
T
L
V
F
E
F
C
D
Q
D
L
K
K
Y
F
D
S
---
C
---
N
-
G
---
D
L
D
P
E
I
V
K
S
F
L
F
Q
L
L
K
G
L
G
F
C
H
S
R
N
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
R
-
N
-
G
E
L
K
L
A
D
F
G
L
A
R
A
F
G
--
I
P
V
R
--
S
A
E
V
V
T
L
W
Y
R
P
P
D
V
L
F
G
A
K
L
Y
S
T
S
I
D
M
W
S
A
G
C
I
F
A
E
L
A
-
N
A
G
R
P
L
F
P
G
N
D
V
----
D
D
Q
L
K
R
I
F
R
L
L
G
T
P
T
E
E
Q
W
P
S
M
T
K
L
P
D
Y
K
----
P
----
Y
P
M
Y
-
P
-
A
T
T
S
L
----
V
N
V
-
V
-
P
K
-
L
N
A
T
G
R
D
L
L
Q
N
L
L
K
C
N
P
V
Q
R
I
S
A
E
E
A
L
Q
H
P
Y
F
S
D
F
---------------------------------------------------
70
PsiBlast_CBE
85.76
53%
-109
- C1 -
2XNB
1
CDK2_HUMAN
A:
[1-296]
------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
L
D
---T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
-----
T
------
E
N
------
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
---
A
L
T
---
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
-
E
-
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
--
V
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
-
R
R
A
L
F
P
G
D
S
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
----
P
---
S
F
P
K
W
-
A
-
R
Q
-
D
F
----
S
K
V
-
V
-
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
------------------------------------------
86
PsiBlast_CBE
85.75
53%
-111
- C1 -
2VTO
1
CDK2_HUMAN
A:
[1-296]
------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
---------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
-----
T
------
E
N
------
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
---
A
L
T
---
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
-
E
-
G
A
I
K
L
A
D
F
G
L
A
R
A
F
----------
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
-
R
R
A
L
F
P
G
D
S
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
----
P
---
S
F
P
K
W
-
A
-
R
Q
-
D
F
----
S
K
V
-
V
-
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
------------------------------------------
15
PsiBlast_PDB
85.67
53%
-104
- C1 -
1OIU
1
CDK2_HUMAN
A:
[2-300]
---------------------------------------------------------------------------------------------------------------------------------------
P
G
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
L
----T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
-----
T
------
E
N
------
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
---
A
L
T
---
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
-
E
-
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
--
V
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
-
R
R
A
L
F
P
G
D
S
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
----
P
---
S
F
P
K
W
-
A
-
R
Q
-
D
F
----
S
K
V
-
V
-
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
-------------------------------------------
57
PsiBlast_CBE
85.65
53%
-109
- C1 -
3LFS
1
CDK2_HUMAN
A:
[1-296]
------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
----------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
-----
T
------
E
N
------
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
---
A
L
T
---
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
-
E
-
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
--
V
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
-
R
R
A
L
F
P
G
D
S
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
----
P
---
S
F
P
K
W
-
A
-
R
Q
-
D
F
----
S
K
V
-
V
-
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
------------------------------------------
67
PsiBlast_CBE
85.60
53%
-103
- C1 -
3EJ1
1
CDK2_HUMAN
C:
[1-296]
------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
L
----T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
-----
T
------
E
N
------
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
---
A
L
T
---
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
-
E
-
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
--
V
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
-
R
R
A
L
F
P
G
D
S
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
----
P
---
S
F
P
K
W
-
A
-
R
Q
-
D
F
----
S
K
V
-
V
-
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
-------------------------------------------
12
PsiBlast_PDB
85.60
53%
-111
- C1 -
3EZV
1
CDK2_HUMAN
A:
[3-298]
------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
---------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
-----
T
------
E
N
------
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
---
A
L
T
---
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
-
E
-
G
A
I
K
L
A
D
F
G
L
----------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
-
R
R
A
L
F
P
G
D
S
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
----
P
---
S
F
P
K
W
-
A
-
R
Q
-
D
F
----
S
K
V
-
V
-
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
------------------------------------------
49
PsiBlast_CBE
85.57
53%
-112
- C1 -
3ULI
1
CDK2_HUMAN
A:
[1-296]
------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
-----
T
------
E
N
------
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
---
A
L
T
---
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
-
E
-
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
--
V
-------
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
-
R
R
A
L
F
P
G
D
S
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
----
P
---
S
F
P
K
W
-
A
-
R
Q
-
D
F
----
S
K
V
-
V
-
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
------------------------------------------
95
PsiBlast_CBE
85.51
53%
-108
- C1 -
2UZO
1
CDK2_HUMAN
A:
[1-296]
------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
L
--------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
-----
T
------
E
N
------
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
---
A
L
T
---
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
-
E
-
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
--
V
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
-
R
R
A
L
F
P
G
D
S
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
----
P
---
S
F
P
K
W
-
A
-
R
Q
-
D
F
----
S
K
V
-
V
-
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
--------------------------------------------
16
PsiBlast_PDB
85.40
53%
-101
- C1 -
1OIY
1
CDK2_HUMAN
A:
[4-300]
-----------------------------------------------------------------------------------------------------------------------------------------
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
L
----T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
-----
T
------
E
N
------
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
---
A
L
T
---
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
-
E
-
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
--
V
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
-
R
R
A
L
F
P
G
D
S
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
----
P
---
S
F
P
K
W
-
A
-
R
Q
-
D
F
----
S
K
V
-
V
-
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
--------------------------------------------
78
PsiBlast_CBE
85.38
53%
-109
- C1 -
2W06
2
CDK2_HUMAN
A:
[1-296]
------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
---------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
-----
T
------
E
N
------
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
---
A
L
T
---
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
-
E
-
G
A
I
K
L
A
D
F
G
L
A
R
A
F
-----------
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
-
R
R
A
L
F
P
G
D
S
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
----
P
---
S
F
P
K
W
-
A
-
R
Q
-
D
F
----
S
K
V
-
V
-
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
------------------------------------------
50
PsiBlast_CBE
85.33
53%
-110
- C1 -
3TIZ
9
CDK2_HUMAN
A:
[2-296]
-------------------------------------------------------------------------------------------------------------------------------------------
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
-----T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
-----
T
------
E
N
------
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
---
A
L
T
---
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
-
E
-
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
--
V
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
-
R
R
A
L
F
P
G
D
S
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
----
P
---
S
F
P
K
W
-
A
-
R
Q
-
D
F
----
S
K
V
-
V
-
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
------------------------------------------
71
PsiBlast_CBE
85.26
53%
-108
- C1 -
2XMY
1
CDK2_HUMAN
A:
[1-296]
------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
----
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
-----
T
------
E
N
------
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
---
A
L
T
---
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
-
E
-
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
--
V
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
-
R
R
A
L
F
P
G
D
S
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
----
P
---
S
F
P
K
W
-
A
-
R
Q
-
D
F
----
S
K
V
-
V
-
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
------------------------------------------
2
PsiBlast_PDB
85.19
57%
-109
- C1 -
4AU8
2
CDK5_HUMAN
A:
[6-290]
-------------------------------------------------------------------------------------------------------------------------------------------
Q
K
Y
E
K
L
E
K
I
G
E
G
T
Y
G
T
V
F
K
A
K
N
R
--
E
T
H
E
I
V
A
L
K
R
V
-----------
P
S
S
A
L
R
E
I
C
L
L
K
E
L
K
H
K
N
I
V
R
L
H
D
V
L
--
H
--------------------
K
L
T
L
V
F
E
F
C
D
Q
D
L
K
K
Y
F
D
S
---
C
---
N
-
G
---
D
L
D
P
E
I
V
K
S
F
L
F
Q
L
L
K
G
L
G
F
C
H
S
R
N
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
R
-
N
-
G
E
L
K
L
A
D
F
G
L
A
R
A
F
G
--
I
P
V
R
--
S
A
E
V
V
T
L
W
Y
R
P
P
D
V
L
F
G
A
K
L
Y
S
T
S
I
D
M
W
S
A
G
C
I
F
A
E
L
A
N
A
-
G
R
P
L
F
P
G
N
D
V
----
D
D
Q
L
K
R
I
F
R
L
L
G
T
P
T
E
E
Q
W
P
S
M
T
K
L
P
D
Y
K
----
P
Y
----
P
M
Y
P
A
-
T
T
-
S
L
----
V
N
V
-
V
-
P
K
-
L
N
A
T
G
R
D
L
L
Q
N
L
L
K
C
N
P
V
Q
R
I
S
A
E
E
A
L
Q
H
P
Y
F
S
D
F
---------------------------------------------------
56
PsiBlast_CBE
85.15
53%
-111
- C1 -
3NS9
1
CDK2_HUMAN
A:
[3-296]
--------------------------------------------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
---------
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
-----
T
------
E
N
------
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
---
A
L
T
---
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
-
E
-
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
--
V
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
-
R
R
A
L
F
P
G
D
S
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
----
P
---
S
F
P
K
W
-
A
-
R
Q
-
D
F
----
S
K
V
-
V
-
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
------------------------------------------
94
PsiBlast_CBE
85.09
53%
-109
- C1 -
2V0D
1
CDK2_HUMAN
A:
[1-296]
------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
L
--------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
-----
T
------
E
N
------
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
---
A
L
T
---
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
-
E
-
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
--
V
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
-
R
R
A
L
F
P
G
D
S
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
----
P
---
S
F
P
K
W
-
A
-
R
Q
-
D
F
----
S
K
V
-
V
-
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
------------------------------------------
59
PsiBlast_CBE
85.09
53%
-115
- C1 -
3LFN
1
CDK2_HUMAN
A:
[1-296]
------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
-----T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
-----
T
------
E
N
------
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
---
A
L
T
---
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
-
E
-
G
A
I
K
L
A
D
F
G
L
A
R
A
-----------
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
-
R
R
A
L
F
P
G
D
S
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
----
P
---
S
F
P
K
W
-
A
-
R
Q
-
D
F
----
S
K
V
-
V
-
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
------------------------------------------
68
PsiBlast_CBE
85.08
53%
-104
- C1 -
3EJ1
1
CDK2_HUMAN
A:
[1-296]
------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
L
----T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
-----
T
------
E
N
------
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
---
A
L
T
---
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
-
E
-
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
--
V
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
-
R
R
A
L
F
P
G
D
S
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
----
P
---
S
F
P
K
W
-
A
-
R
Q
-
D
F
----
S
K
V
-
V
-
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
------------------------------------------
17
PsiBlast_PDB
85.08
53%
-103
- C1 -
4CFN
1
CDK2_HUMAN
A:
[2-300]
---------------------------------------------------------------------------------------------------------------------------------------
P
G
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
L
----T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
-----
T
------
E
N
------
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
---
A
L
T
---
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
-
E
-
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
--
V
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
-
R
R
A
L
F
P
G
D
S
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
----
P
---
S
F
P
K
W
-
A
-
R
Q
-
D
F
----
S
K
V
-
V
-
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
-------------------------------------------
51
PsiBlast_CBE
85.04
53%
-113
- C1 -
3TIY
13
CDK2_HUMAN
A:
[2-296]
-------------------------------------------------------------------------------------------------------------------------------------------
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
-----T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
-----
T
------
E
N
------
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
---
A
L
T
---
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
-
E
-
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
--
V
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
-
R
R
A
L
F
P
G
D
S
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
----
P
---
S
F
P
K
W
-
A
-
R
Q
-
D
F
----
S
K
V
-
V
-
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
------------------------------------------
14
PsiBlast_PDB
85.04
53%
-104
- C1 -
1OI9
1
CDK2_HUMAN
A:
[4-300]
-----------------------------------------------------------------------------------------------------------------------------------------
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
L
--
T
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
-----
T
------
E
N
------
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
---
A
L
T
---
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
-
E
-
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
--
V
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
-
R
R
A
L
F
P
G
D
S
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
----
P
---
S
F
P
K
W
-
A
-
R
Q
-
D
F
----
S
K
V
-
V
-
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
--------------------------------------------
44
PsiBlast_CBE
85.01
53%
-115
- C1 -
4BZD
1
CDK2_HUMAN
A:
[2-297]
------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
-
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
L
--------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
-----
T
------
E
N
------
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
---
A
L
T
---
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
-
E
-
G
A
I
K
L
A
D
F
G
L
----------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
-
R
R
A
L
F
P
G
D
S
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
----
P
---
S
F
P
K
W
-
A
-
R
Q
-
D
F
----
S
K
V
-
V
-
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
------------------------------------------
93
PsiBlast_CBE
84.96
53%
-112
- C1 -
2VTA
3
CDK2_HUMAN
A:
[1-296]
------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
-----------
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
-----
T
------
E
N
------
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
---
A
L
T
---
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
-
E
-
G
A
I
K
L
A
D
F
G
L
A
R
A
F
-------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
-
R
R
A
L
F
P
G
D
S
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
----
P
---
S
F
P
K
W
-
A
-
R
Q
-
D
F
----
S
K
V
-
V
-
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
------------------------------------------
48
PsiBlast_CBE
84.95
53%
-109
- C1 -
3UNJ
1
CDK2_HUMAN
A:
[1-296]
------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
-----T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
-----
T
------
E
N
------
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
---
A
L
T
---
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
-
E
-
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
--
V
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
-
R
R
A
L
F
P
G
D
S
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
----
P
---
S
F
P
K
W
-
A
-
R
Q
-
D
F
----
S
K
V
-
V
-
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
------------------------------------------
10
PsiBlast_PDB
84.95
53%
-103
- C1 -
2IW8
1
CDK2_HUMAN
A:
[4-300]
-----------------------------------------------------------------------------------------------------------------------------------------
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
-----
T
------
E
N
------
K
L
Y
L
V
F
E
H
V
D
Q
D
L
K
K
F
M
D
A
---
S
---
A
L
T
---
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
-
E
-
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
--
V
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
-
R
R
A
L
F
P
G
D
S
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
----
P
---
S
F
P
K
W
-
A
-
R
Q
-
D
F
----
S
K
V
-
V
-
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
-------------------------------------------
92
PsiBlast_CBE
84.94
53%
-113
- C1 -
2VTH
2
CDK2_HUMAN
A:
[1-296]
------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
-----------
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
-----
T
------
E
N
------
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
---
A
L
T
---
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
-
E
-
G
A
I
K
L
A
D
F
G
L
A
R
A
F
-------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
-
R
R
A
L
F
P
G
D
S
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
----
P
---
S
F
P
K
W
-
A
-
R
Q
-
D
F
----
S
K
V
-
V
-
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
------------------------------------------
45
PsiBlast_CBE
84.80
53%
-117
- C1 -
4BGH
1
CDK2_HUMAN
A:
[1-296]
------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
-----------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
-----
T
------
E
N
------
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
---
A
L
T
---
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
-
E
-
G
A
I
K
L
A
D
F
G
L
A
----------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
-
R
R
A
L
F
P
G
D
S
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
----
P
---
S
F
P
K
W
-
A
-
R
Q
-
D
F
----
S
K
V
-
V
-
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
------------------------------------------
20
PsiBlast_PDB
84.80
53%
-103
- C1 -
1H1P
1
CDK2_HUMAN
A:
[5-301]
-----------------------------------------------------------------------------------------------------------------------------------------
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
-----
T
------
E
N
------
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
---
A
L
T
---
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
-
E
-
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
--
V
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
-
R
R
A
L
F
P
G
D
S
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
----
P
---
S
F
P
K
W
-
A
-
R
Q
-
D
F
----
S
K
V
-
V
-
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
--------------------------------------------
18
PsiBlast_PDB
84.79
53%
-100
- C1 -
4EOS
1
CDK2_HUMAN
A:
[2-299]
----------------------------------------------------------------------------------------------------------------------------------------
G
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
L
D
----
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
-----
T
------
E
N
------
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
---
A
L
T
---
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
-
E
-
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
--
V
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
-
R
R
A
L
F
P
G
D
S
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
----
P
---
S
F
P
K
W
-
A
-
R
Q
-
D
F
----
S
K
V
-
V
-
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
-------------------------------------------
79
PsiBlast_CBE
84.76
53%
-117
- C1 -
2W05
1
CDK2_HUMAN
A:
[1-296]
------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
-----------
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
-----
T
------
E
N
------
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
---
A
L
T
---
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
-
E
-
G
A
I
K
L
A
D
F
G
L
---------------
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
-
R
R
A
L
F
P
G
D
S
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
----
P
---
S
F
P
K
W
-
A
-
R
Q
-
D
F
----
S
K
V
-
V
-
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
------------------------------------------
52
PsiBlast_CBE
84.70
53%
-112
- C1 -
3TI1
9
CDK2_HUMAN
A:
[1-296]
------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
-----T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
-----
T
------
E
N
------
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
---
A
L
T
---
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
-
E
-
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
--
V
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
-
R
R
A
L
F
P
G
D
S
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
----
P
---
S
F
P
K
W
-
A
-
R
Q
-
D
F
----
S
K
V
-
V
-
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
------------------------------------------
43
PsiBlast_CBE
84.70
53%
-112
- C1 -
4D1X
1
CDK2_HUMAN
A:
[3-296]
--------------------------------------------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
-------------
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
-----
T
------
E
N
------
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
---
A
L
T
---
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
-
E
-
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-------------
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
-
R
R
A
L
F
P
G
D
S
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
----
P
---
S
F
P
K
W
-
A
-
R
Q
-
D
F
----
S
K
V
-
V
-
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
------------------------------------------
11
PsiBlast_PDB
84.70
53%
-115
- C1 -
3EZR
2
CDK2_HUMAN
A:
[3-298]
------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
---------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
-----
T
------
E
N
------
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
---
A
L
T
---
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
-
E
-
G
A
I
K
L
A
D
F
--------------------
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
-
R
R
A
L
F
P
G
D
S
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
----
P
---
S
F
P
K
W
-
A
-
R
Q
-
D
F
----
S
K
V
-
V
-
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
------------------------------------------
91
PsiBlast_CBE
84.69
53%
-115
- C1 -
2VTI
1
CDK2_HUMAN
A:
[1-296]
------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
----------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
-----
T
------
E
N
------
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
---
A
L
T
---
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
-
E
-
G
A
I
K
L
A
D
F
G
L
A
R
A
F
------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
-
R
R
A
L
F
P
G
D
S
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
----
P
---
S
F
P
K
W
-
A
-
R
Q
-
D
F
----
S
K
V
-
V
-
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
------------------------------------------
89
PsiBlast_CBE
84.69
53%
-110
- C1 -
2VTL
1
CDK2_HUMAN
A:
[1-296]
------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
----------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
-----
T
------
E
N
------
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
---
A
L
T
---
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
-
E
-
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
--
V
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
-
R
R
A
L
F
P
G
D
S
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
----
P
---
S
F
P
K
W
-
A
-
R
Q
-
D
F
----
S
K
V
-
V
-
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
------------------------------------------
63
PsiBlast_CBE
84.47
53%
-102
- C1 -
3F5X
2
CDK2_HUMAN
C:
[1-296]
------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
-----
T
------
E
N
------
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
---
A
L
T
---
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
-
E
-
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
--
V
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
-
R
R
A
L
F
P
G
D
S
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
----
P
---
S
F
P
K
W
-
A
-
R
Q
-
D
F
----
S
K
V
-
V
-
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
------------------------------------------
99
PsiBlast_CBE
84.42
53%
-114
- C1 -
2R64
1
CDK2_HUMAN
A:
[1-296]
------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
----------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
-----
T
------
E
N
------
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
---
A
L
T
---
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
-
E
-
G
A
I
K
L
A
D
F
G
L
A
R
A
F
-------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
-
R
R
A
L
F
P
G
D
S
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
----
P
---
S
F
P
K
W
-
A
-
R
Q
-
D
F
----
S
K
V
-
V
-
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
------------------------------------------
81
PsiBlast_CBE
84.36
53%
-108
- C1 -
2VU3
1
CDK2_HUMAN
A:
[1-296]
------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
L
-----------
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
-----
T
------
E
N
------
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
---
A
L
T
---
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
-
E
-
G
A
I
K
L
A
D
F
G
----
F
G
--
V
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
-
R
R
A
L
F
P
G
D
S
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
----
P
---
S
F
P
K
W
-
A
-
R
Q
-
D
F
----
S
K
V
-
V
-
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
------------------------------------------
19
PsiBlast_PDB
84.36
53%
-103
- C1 -
4EOQ
1
CDK2_HUMAN
A:
[3-300]
----------------------------------------------------------------------------------------------------------------------------------------
G
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
L
----T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
-----
T
------
E
N
------
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
---
A
L
T
---
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
-
E
-
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
--
V
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
-
R
R
A
L
F
P
G
D
S
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
----
P
---
S
F
P
K
W
-
A
-
R
Q
-
D
F
----
S
K
V
-
V
-
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
-------------------------------------------
47
PsiBlast_CBE
84.35
53%
-105
- C1 -
3UNK
1
CDK2_HUMAN
A:
[1-296]
------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
----
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
-----
T
------
E
N
------
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
---
A
L
T
---
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
-
E
-
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
--
V
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
-
R
R
A
L
F
P
G
D
S
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
----
P
---
S
F
P
K
W
-
A
-
R
Q
-
D
F
----
S
K
V
-
V
-
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
------------------------------------------
26
PsiBlast_CBE
84.33
53%
-105
- C1 -
4LYN
1
CDK2_HUMAN
A:
[1-296]
------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
-----
T
------
E
N
------
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
---
A
L
T
---
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
-
E
-
G
A
I
K
L
A
D
F
G
L
A
R
A
F
-------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
-
R
R
A
L
F
P
G
D
S
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
----
P
---
S
F
P
K
W
-
A
-
R
Q
-
D
F
----
S
K
V
-
V
-
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
------------------------------------------
69
PsiBlast_CBE
84.32
53%
-107
- C1 -
3EID
1
CDK2_HUMAN
A:
[1-296]
------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
L
----T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
-----
T
------
E
N
------
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
---
A
L
T
---
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
-
E
-
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
--
V
P
V
R
T
Y
T
--
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
-
R
R
A
L
F
P
G
D
S
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
----
P
---
S
F
P
K
W
-
A
-
R
Q
-
D
F
----
S
K
V
-
V
-
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
-------------------------------------------
90
PsiBlast_CBE
84.26
53%
-115
- C1 -
2VTJ
2
CDK2_HUMAN
A:
[1-296]
------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
-----------
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
-----
T
------
E
N
------
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
---
A
L
T
---
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
-
E
-
G
A
I
K
L
A
D
F
G
L
A
R
---------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
-
R
R
A
L
F
P
G
D
S
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
----
P
---
S
F
P
K
W
-
A
-
R
Q
-
D
F
----
S
K
V
-
V
-
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
------------------------------------------
76
PsiBlast_CBE
84.21
53%
-108
- C1 -
2W1H
1
CDK2_HUMAN
A:
[1-296]
------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
-----T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
-----
T
------
E
N
------
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
---
A
L
T
---
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
-
E
-
G
A
I
K
L
A
D
F
G
L
A
R
A
F
-------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
-
R
R
A
L
F
P
G
D
S
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
----
P
---
S
F
P
K
W
-
A
-
R
Q
-
D
F
----
S
K
V
-
V
-
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
------------------------------------------
55
PsiBlast_CBE
84.14
53%
-112
- C1 -
3S2P
1
CDK2_HUMAN
A:
[1-296]
------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
----------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
-----
T
------
E
N
------
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
---
A
L
T
---
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
-
E
-
G
A
I
K
L
A
D
F
G
L
A
R
A
F
-------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
-
R
R
A
L
F
P
G
D
S
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
----
P
---
S
F
P
K
W
-
A
-
R
Q
-
D
F
----
S
K
V
-
V
-
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
------------------------------------------
85
PsiBlast_CBE
84.12
53%
-112
- C1 -
2VTP
1
CDK2_HUMAN
A:
[1-296]
------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
----------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
-----
T
------
E
N
------
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
---
A
L
T
---
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
-
E
-
G
A
I
K
L
A
D
F
G
L
A
R
A
F
-----------
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
-
R
R
A
L
F
P
G
D
S
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
----
P
---
S
F
P
K
W
-
A
-
R
Q
-
D
F
----
S
K
V
-
V
-
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
------------------------------------------
62
PsiBlast_CBE
84.10
53%
-109
- C1 -
3FZ1
1
CDK2_HUMAN
A:
[1-296]
------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
---------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
-----
T
------
E
N
------
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
---
A
L
T
---
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
-
E
-
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
---------
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
-
R
R
A
L
F
P
G
D
S
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
----
P
---
S
F
P
K
W
-
A
-
R
Q
-
D
F
----
S
K
V
-
V
-
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
------------------------------------------
21
PsiBlast_CBE
84.06
57%
-115
- C1 -
4AU8
2
CDK5_HUMAN
B:
[6-290]
-------------------------------------------------------------------------------------------------------------------------------------------
Q
K
Y
E
K
L
E
K
I
G
E
G
T
Y
G
T
V
F
K
A
K
N
R
--
E
T
H
E
I
V
A
L
K
R
V
R
L
-----
E
-
G
V
P
S
S
A
L
R
E
I
C
L
L
K
E
L
K
H
K
N
I
V
R
L
H
D
V
L
--
H
-----
S
-------
K
------
K
L
T
L
V
F
E
F
C
D
Q
D
L
K
K
Y
F
D
S
---
C
---
N
-
G
---
D
L
D
P
E
I
V
K
S
F
L
F
Q
L
L
K
G
L
G
F
C
H
S
R
N
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
R
-
N
-
G
E
L
K
L
A
D
F
G
L
A
R
A
F
G
--
I
P
V
------
V
V
T
L
W
Y
R
P
P
D
V
L
F
G
A
K
L
Y
S
T
S
I
D
M
W
S
A
G
C
I
F
A
E
L
A
N
A
-
G
R
P
L
F
P
G
N
D
V
----
D
D
Q
L
K
R
I
F
R
L
L
G
T
P
T
E
E
Q
W
P
S
M
T
K
L
P
D
Y
K
----
P
Y
----
P
M
Y
P
A
-
T
T
-
S
L
----
V
N
V
-
V
-
P
K
-
L
N
A
T
G
R
D
L
L
Q
N
L
L
K
C
N
P
V
Q
R
I
S
A
E
E
A
L
Q
H
P
Y
F
S
D
F
---------------------------------------------------
87
PsiBlast_CBE
83.90
53%
-113
- C1 -
2VTN
1
CDK2_HUMAN
A:
[1-296]
------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
----------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
-----
T
------
E
N
------
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
---
A
L
T
---
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
-
E
-
G
A
I
K
L
A
D
F
G
------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
-
R
R
A
L
F
P
G
D
S
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
----
P
---
S
F
P
K
W
-
A
-
R
Q
-
D
F
----
S
K
V
-
V
-
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
------------------------------------------
5
PsiBlast_PDB
83.69
56%
-112
- C1 -
1UNL
1
CDK5_HUMAN
A:
[1-286]
------------------------------------------------------------------------------------------------------------------------------------------
M
Q
K
Y
E
K
L
E
K
I
G
E
G
T
Y
G
T
V
F
K
A
K
N
R
--
E
T
H
E
I
V
A
L
K
R
V
R
L
D
-
D
D
D
E
-
G
V
P
S
S
A
L
R
E
I
C
L
L
K
E
L
K
H
K
N
I
V
R
L
H
D
V
L
--
H
-----
S
------
D
K
------
K
L
T
L
V
F
E
F
C
D
Q
D
L
K
K
Y
F
D
S
---
C
---
N
-
G
---
D
L
D
P
E
I
V
K
S
F
L
F
Q
L
L
K
G
L
G
F
C
H
S
R
N
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
R
-
N
-
G
E
L
K
L
A
N
F
G
L
A
R
A
F
G
--
I
P
V
R
C
Y
S
A
E
V
V
T
L
W
Y
R
P
P
D
V
L
F
G
A
K
L
Y
S
T
S
I
D
M
W
S
A
G
C
I
F
A
E
L
A
N
A
-
G
R
P
L
F
P
G
N
D
V
----
D
D
Q
L
K
R
I
F
R
L
L
G
T
P
T
E
E
Q
W
P
S
M
T
K
L
P
D
Y
K
----
P
Y
----
P
M
Y
P
A
-
T
T
-
S
L
----
V
N
V
-
V
-
P
K
-
L
N
A
T
G
R
D
L
L
Q
N
L
L
K
C
N
P
V
Q
R
I
S
A
E
E
A
L
Q
H
P
Y
F
S
D
F
C
P
P
------------------------------------------------
65
PsiBlast_CBE
83.66
53%
-104
- C1 -
3EOC
1
CDK2_HUMAN
C:
[1-296]
------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
L
----T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
-----
T
------
E
N
------
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
---
A
L
T
---
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
-
E
-
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
--
V
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
-
R
R
A
L
F
P
G
D
S
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
----
P
---
S
F
P
K
W
-
A
-
R
Q
-
D
F
----
S
K
V
-
V
-
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
--------------------------------------------
97
PsiBlast_CBE
83.61
53%
-102
- C1 -
2UUE
1
CDK2_HUMAN
C:
[1-296]
------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
-----
T
------
E
N
------
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
---
A
L
T
---
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
-
E
-
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
--
V
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
-
R
R
A
L
F
P
G
D
S
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
----
P
---
S
F
P
K
W
-
A
-
R
Q
-
D
F
----
S
K
V
-
V
-
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
-------------------------------------------
27
PsiBlast_CBE
83.60
53%
-109
- C1 -
4KD1
2
CDK2_HUMAN
A:
[1-296]
------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
-----
T
------
E
N
------
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
---
A
L
T
---
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
-
E
-
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
--
V
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
-
R
R
A
L
F
P
G
D
S
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
----
P
---
S
F
P
K
W
-
A
-
R
Q
-
D
F
----
S
K
V
-
V
-
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
------------------------------------------
83
PsiBlast_CBE
83.56
53%
-109
- C1 -
2VTR
1
CDK2_HUMAN
A:
[1-296]
------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
----------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
-----
T
------
E
N
------
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
---
A
L
T
---
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
-
E
-
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
--
V
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
-
R
R
A
L
F
P
G
D
S
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
----
P
---
S
F
P
K
W
-
A
-
R
Q
-
D
F
----
S
K
V
-
V
-
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
------------------------------------------
64
PsiBlast_CBE
83.53
53%
-106
- C1 -
3F5X
2
CDK2_HUMAN
A:
[1-296]
------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
-----
T
------
E
N
------
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
---
A
L
T
---
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
-
E
-
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
--
V
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
-
R
R
A
L
F
P
G
D
S
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
----
P
---
S
F
P
K
W
-
A
-
R
Q
-
D
F
----
S
K
V
-
V
-
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
-
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
------------------------------------------
98
PsiBlast_CBE
83.47
53%
-99
- C1 -
2UUE
1
CDK2_HUMAN
A:
[1-296]
------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
-----
T
------
E
N
------
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
---
A
L
T
---
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
-
E
-
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
--
V
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
-
R
R
A
L
F
P
G
D
S
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
----
P
---
S
F
P
K
W
-
A
-
R
Q
-
D
F
----
S
K
V
-
V
-
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
--------------------------------------------
66
PsiBlast_CBE
83.45
53%
-103
- C1 -
3EOC
1
CDK2_HUMAN
A:
[1-296]
------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
L
----T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
-----
T
------
E
N
------
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
---
A
L
T
---
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
-
E
-
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
--
V
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
-
R
R
A
L
F
P
G
D
S
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
----
P
---
S
F
P
K
W
-
A
-
R
Q
-
D
F
----
S
K
V
-
V
-
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
------------------------------------------
58
PsiBlast_CBE
83.23
53%
-112
- C1 -
3LFQ
1
CDK2_HUMAN
A:
[1-296]
------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
-----------
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
-----
T
------
E
N
------
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
---
A
L
T
---
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
-
E
-
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
--
V
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
-
R
R
A
L
F
P
G
D
S
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
----
P
---
S
F
P
K
W
-
A
-
R
Q
-
D
F
----
S
K
V
-
V
-
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
------------------------------------------
75
PsiBlast_CBE
83.21
53%
-100
- C1 -
2WEV
1
CDK2_HUMAN
A:
[1-296]
------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
-----
T
------
E
N
------
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
---
A
L
T
---
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
-
E
-
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
--
V
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
-
R
R
A
L
F
P
G
D
S
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
----
P
---
S
F
P
K
W
-
A
-
R
Q
-
D
F
----
S
K
V
-
V
-
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
--------------------------------------------
28
PsiBlast_CBE
83.18
53%
-99
- C1 -
4FX3
1
CDK2_HUMAN
C:
[1-296]
------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
-----
T
------
E
N
------
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
---
A
L
T
---
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
-
E
-
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
--
V
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
-
R
R
A
L
F
P
G
D
S
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
----
P
---
S
F
P
K
W
-
A
-
R
Q
-
D
F
----
S
K
V
-
V
-
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
------------------------------------------
29
PsiBlast_CBE
83.03
53%
-102
- C1 -
4FX3
2
CDK2_HUMAN
A:
[1-296]
------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
-----
T
------
E
N
------
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
---
A
L
T
---
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
-
E
-
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
--
V
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
-
R
R
A
L
F
P
G
D
S
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
----
P
---
S
F
P
K
W
-
A
-
R
Q
-
D
F
----
S
K
V
-
V
-
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
------------------------------------------
74
PsiBlast_CBE
83.02
53%
-103
- C1 -
2WEV
1
CDK2_HUMAN
C:
[1-296]
------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
-----
T
------
E
N
------
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
---
A
L
T
---
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
-
E
-
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
--
V
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
-
R
R
A
L
F
P
G
D
S
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
----
P
---
S
F
P
K
W
-
A
-
R
Q
-
D
F
----
S
K
V
-
V
-
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
-------------------------------------------
72
PsiBlast_CBE
82.95
53%
-102
- C1 -
2X1N
1
CDK2_HUMAN
C:
[1-296]
------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
-----
T
------
E
N
------
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
---
A
L
T
---
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
-
E
-
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
--
V
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
-
R
R
A
L
F
P
G
D
S
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
----
P
---
S
F
P
K
W
-
A
-
R
Q
-
D
F
----
S
K
V
-
V
-
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
-------------------------------------------
88
PsiBlast_CBE
82.93
53%
-108
- C1 -
2VTM
1
CDK2_HUMAN
A:
[1-296]
------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
----------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
-----
T
------
E
N
------
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
---
A
L
T
---
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
-
E
-
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
--
V
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
-
R
R
A
L
F
P
G
D
S
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
----
P
---
S
F
P
K
W
-
A
-
R
Q
-
D
F
----
S
K
V
-
V
-
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
------------------------------------------
73
PsiBlast_CBE
82.64
53%
-99
- C1 -
2X1N
1
CDK2_HUMAN
A:
[1-296]
------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
-----
T
------
E
N
------
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
---
A
L
T
---
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
-
E
-
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
--
V
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
-
R
R
A
L
F
P
G
D
S
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
----
P
---
S
F
P
K
W
-
A
-
R
Q
-
D
F
----
S
K
V
-
V
-
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
--------------------------------------------
24
PsiBlast_CBE
82.52
53%
-117
- C1 -
5D1J
1
?
A:
[1-296]
------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
--
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
----------------
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
-----
T
------
E
N
------
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
---
A
L
T
---
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
-
E
-
G
A
I
K
L
A
D
F
-------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
-
R
R
A
L
F
P
G
D
S
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
----
P
---
S
F
P
K
W
-
A
-
R
Q
-
D
F
----
S
K
V
-
V
-
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
------------------------------------------
3
PsiBlast_PDB
82.43
56%
-116
- C1 -
1UNG
1
CDK5_HUMAN
A:
[1-286]
------------------------------------------------------------------------------------------------------------------------------------------
M
Q
K
Y
E
K
L
E
K
I
----
Y
G
T
V
F
K
A
K
N
R
--
E
T
H
E
I
V
A
L
K
R
V
R
L
D
-
D
D
D
E
-
G
V
P
S
S
A
L
R
E
I
C
L
L
K
E
L
K
H
K
N
I
V
R
L
H
D
V
L
--
H
-----
S
------
D
K
------
K
L
T
L
V
F
E
F
C
D
Q
D
L
K
K
Y
F
D
S
---
C
---
N
-
G
---
D
L
D
P
E
I
V
K
S
F
L
F
Q
L
L
K
G
L
G
F
C
H
S
R
N
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
R
-
N
-
G
E
L
K
L
A
N
F
G
L
A
R
A
F
G
--
I
P
V
R
C
Y
S
A
E
V
V
T
L
W
Y
R
P
P
D
V
L
F
G
A
K
L
Y
S
T
S
I
D
M
W
S
A
G
C
I
F
A
E
L
A
N
A
-
G
R
P
L
F
P
G
N
D
V
----
D
D
Q
L
K
R
I
F
R
L
L
G
T
P
T
E
E
Q
W
P
S
M
T
K
L
P
D
Y
K
----
P
Y
----
P
M
Y
P
A
-
T
T
-
S
L
----
V
N
V
-
V
-
P
K
-
L
N
A
T
G
R
D
L
L
Q
N
L
L
K
C
N
P
V
Q
R
I
S
A
E
E
A
L
Q
H
P
Y
F
S
D
F
C
P
P
------------------------------------------------
128
HHSearch
82.32
51%
-108
- C1 -
3NIZ
1
?
A:
[15-309]
-------------------------------------------------------------------------------------------------------------------------------------
Y
F
Q
G
L
M
E
K
Y
Q
K
L
E
K
V
G
E
G
T
Y
G
V
V
Y
K
A
K
D
---
S
Q
G
R
I
V
A
L
K
R
I
R
--------
G
I
P
S
T
A
I
R
E
I
S
L
L
K
E
L
H
H
P
N
I
V
S
L
I
D
V
I
--
H
-----
S
------
E
R
------
C
L
T
L
V
F
E
F
M
E
K
D
L
K
K
V
L
D
E
---
N
---
K
-
T
---
G
L
Q
D
S
Q
I
K
I
Y
L
Y
Q
L
L
R
G
V
A
H
C
H
Q
H
R
I
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
S
-
D
-
G
A
L
K
L
A
D
F
G
L
A
R
A
F
G
--
I
P
V
R
---
H
E
V
V
T
L
W
Y
R
A
P
D
V
L
M
G
S
K
K
Y
S
T
S
V
D
I
W
S
I
G
C
I
F
A
E
M
I
-
T
-
G
K
P
L
F
P
G
V
T
D
----
D
D
Q
L
P
K
I
F
S
I
L
G
T
P
N
P
R
E
W
P
Q
V
Q
E
L
P
L
W
K
----
Q
R
--
T
F
Q
V
F
-
E
-
K
K
-
P
W
----
S
S
I
-
I
-
P
G
-
F
C
Q
E
G
I
D
L
L
S
N
M
L
C
F
D
P
N
K
R
I
S
A
R
D
A
M
N
H
P
Y
F
K
D
L
D
P
Q
I
-----------------------------------------------
84
PsiBlast_CBE
82.23
53%
-114
- C1 -
2VTQ
1
CDK2_HUMAN
A:
[1-296]
------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
-----------
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
-----
T
------
E
N
------
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
---
A
L
T
---
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
-
E
-
G
A
I
K
L
A
D
F
G
-----------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
-
R
R
A
L
F
P
G
D
S
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
----
P
---
S
F
P
K
W
-
A
-
R
Q
-
D
F
----
S
K
V
-
V
-
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
------------------------------------------
22
PsiBlast_CBE
82.17
56%
-117
- C1 -
3O0G
1
CDK5_HUMAN
B:
[6-286]
-----------------------------------------------------------------------------------------------------------------------------------------------
K
L
E
K
I
G
-----
T
V
F
K
A
--------
E
I
V
A
L
K
R
V
R
----------
P
S
S
A
L
R
E
I
C
L
L
K
E
L
K
H
K
N
I
V
R
L
H
D
V
L
--
H
-----
S
------
D
K
------
K
L
T
L
V
F
E
F
C
D
Q
D
L
K
K
Y
F
D
S
---
C
---
N
-
G
---
D
L
D
P
E
I
V
K
S
F
L
F
Q
L
L
K
G
L
G
F
C
H
S
R
N
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
R
-
N
-
G
E
L
K
L
A
N
F
G
L
A
R
A
F
G
--
I
P
V
R
C
Y
S
A
E
V
V
T
L
W
Y
R
P
P
D
V
L
F
G
A
K
L
Y
S
T
S
I
D
M
W
S
A
G
C
I
F
A
E
L
A
N
A
-
G
R
P
L
F
P
G
N
D
V
----
D
D
Q
L
K
R
I
F
R
L
L
G
T
P
T
E
E
Q
W
P
S
M
T
K
L
P
D
Y
K
----
P
Y
----
P
M
Y
P
A
-
T
T
-
S
L
----
V
N
V
-
V
-
P
K
-
L
N
A
T
G
R
D
L
L
Q
N
L
L
K
C
N
P
V
Q
R
I
S
A
E
E
A
L
Q
H
P
Y
F
S
D
----------------------------------------------------
8
PsiBlast_PDB
81.29
50%
-106
- C1 -
4Y72
1
?
A:
[3-294]
---------------------------------------------------------------------------------------------------------------------------------------
L
G
S
M
E
D
Y
T
K
I
E
K
I
G
E
G
T
Y
G
V
V
Y
K
G
R
H
K
--
T
T
G
Q
V
V
A
M
K
K
I
R
L
E
S
E
E
-
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
R
H
P
N
I
V
S
L
Q
D
V
L
--
M
-----
Q
------
D
S
------
R
L
Y
L
I
F
E
F
L
S
M
D
L
K
K
Y
L
D
S
---
I
PP-
G
-
Q
---
Y
M
D
S
S
L
V
K
S
Y
L
Y
Q
I
L
Q
G
I
V
F
C
H
S
R
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
D
D
-
K
-
G
T
I
K
L
A
D
F
G
L
A
R
A
F
G
--
I
P
I
R
V
Y
T
H
E
V
V
T
L
W
Y
R
S
P
E
V
L
L
G
S
A
R
Y
S
T
P
V
D
I
W
S
I
G
T
I
F
A
E
L
A
-
T
-
K
K
P
L
F
H
G
D
S
E
----
I
D
Q
L
F
R
I
F
R
A
L
G
T
P
N
N
E
V
W
P
E
V
E
S
L
Q
D
Y
K
----
N
---
T
F
P
K
W
-
K
-
P
G
-
S
L
----
A
S
H
-
V
-
K
N
-
L
D
E
N
G
L
D
L
L
S
K
M
L
I
Y
D
P
A
K
R
I
S
G
K
M
A
L
N
H
P
Y
F
N
D
----------------------------------------------------
113
HHSearch
74.06
30%
-99
- C1 -
3EB0
3
?
A:
[7-375]
-------------------------------------------------------------------------------------------------------------------------------------------
K
K
Y
S
L
G
K
T
L
G
T
G
-
F
G
I
V
C
E
V
F
D
I
--
E
S
G
K
R
F
A
L
K
K
V
L
Q
D
--------
P
R
Y
K
N
R
E
L
D
I
M
K
V
L
D
H
V
N
I
I
K
L
V
D
Y
F
--
Y
-----
T
T-----
N
K
------
Y
L
N
V
I
M
E
Y
V
P
D
T
L
H
K
V
L
K
S
F
I
R
S
---
G
-
R
---
S
I
P
M
N
L
I
S
I
Y
I
Y
Q
L
F
R
A
V
G
F
I
H
S
L
G
I
C
H
R
D
I
K
P
Q
N
L
L
V
----
N
S
K
D
-
N
T
L
K
L
C
D
F
G
S
A
K
K
L
I
---
P
S
E
P
S
V
A
Y
I
C
S
R
F
Y
R
A
P
E
L
M
L
G
A
T
E
Y
T
P
S
I
D
L
W
S
I
G
C
V
F
G
E
L
I
-
L
-
G
K
P
L
F
S
G
E
T
S
----
I
D
Q
L
V
R
I
I
Q
I
M
G
T
P
T
K
E
Q
M
I
R
M
--
N
P
H
Y
------
V
--
R
F
P
T
L
-
K
-
A
K
-
D
W
----
R
K
I
-
L
-
P
E
G
T
P
S
L
A
I
D
L
L
E
Q
I
L
R
Y
E
P
D
L
R
I
N
P
Y
E
A
M
A
H
P
F
F
D
H
L
R
N
S
-------I
P
---
Q
L
F
N
F
S
P
Y
E
L
S
I
I
P
G
N
V
L
N
R
I
L
P
K
------------
130
HHSearch
73.86
34%
-103
- C1 -
2B9H
1
FUS3_YEAST
A:
[4-314]
------------------------------------------------------------------------------------------------------------------------------------
R
I
V
Y
N
I
S
S
D
F
Q
L
K
S
L
L
G
E
G
A
Y
G
V
V
C
S
A
T
H
K
--
P
T
G
E
I
V
A
I
K
K
I
E
P
F
-
D
K
-
P
-
L
F
A
L
R
T
L
R
E
I
K
I
L
K
H
F
K
H
E
N
I
I
T
I
F
N
I
Q
--
R
PDSFE
N
------
F
N
------
E
V
Y
I
I
Q
E
L
M
Q
T
D
L
H
R
V
I
S
T
---------
Q
---
M
L
S
D
D
H
I
Q
Y
F
I
Y
Q
T
L
R
A
V
K
V
L
H
G
S
N
V
I
H
R
D
L
K
P
S
N
L
L
I
----
N
S
-
N
-
C
D
L
K
V
C
D
F
G
L
A
R
I
I
D
--------
V
E
F
V
A
T
R
W
Y
R
A
P
E
V
M
L
T
S
A
K
Y
S
R
A
M
D
V
W
S
C
G
C
I
L
A
E
L
F
-
L
-
R
R
P
I
F
P
G
R
D
Y
----
R
H
Q
L
L
L
I
F
G
I
I
G
T
P
H
S
D
N
D
L
R
C
I
E
S
P
R
A
R
----
E
Y
I
K
S
L
P
M
Y
-
P
-
A
A
-
P
L
----
E
K
M
-
F
-
P
R
-
V
N
P
K
G
I
D
L
L
Q
R
M
L
V
F
D
P
A
K
R
I
T
A
K
E
A
L
E
H
P
Y
L
Q
T
Y
H
D
P
N
D
E
P
E
G
E
-
P
---
I
P
P
S
F
F
E
F
D
H
Y
K
E
A
L
-
T
T
K
D
L
K
K
L
I
W
N
E
I
F
S
-----
122
HHSearch
70.59
31%
-99
- C1 -
1J1B
1
GSK3B_HUMAN
A:
[54-374]
-------------------------------------------------------------------------------------------------------------------------------------------
V
S
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
C
--
D
S
G
E
L
V
A
I
K
K
V
L
Q
D
-
K
-------
R
F
K
N
R
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
L
R
Y
F
F
--
Y
-----
S
S
GEKKD
E
V
------
Y
L
N
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
H
---
Y
S
R
A
K
-
Q
---
T
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
----
D
P
-
D
T
A
V
L
K
L
C
D
F
G
S
A
K
Q
L
V
RG
E
P
N
V
S
---
Y
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
-
L
-
G
Q
P
I
F
P
G
D
S
G
----
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
R
E
Q
I
R
E
M
--
N
P
N
Y
T
----
E
F
--
K
F
P
Q
I
-
K
-
A
H
-
P
W
----
T
K
V
-
F
R
P
R
-
T
P
P
E
A
I
A
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
D
P
N
V
K
L
P
N
G
-
R
DTP
A
L
F
N
F
T
T
Q
E
L
S
S
N
P
P
-
L
A
T
I
L
I
P
P
H
A
R
I
Q
A
A
A
----
115
HHSearch
70.20
40%
-95
- C1 -
1UA2
1
CDK7_HUMAN
A:
[13-298]
----------------------------------------------------------------------------------------------------------------------------------------------
E
K
L
D
F
L
G
E
G
Q
F
A
T
V
Y
K
A
R
D
K
--
N
T
N
Q
I
V
A
I
K
K
I
-----------
N
R
T
A
L
R
E
I
K
L
L
Q
E
L
S
H
P
N
I
I
G
L
L
D
A
F
--
G
-----
H
------
K
S
------
N
I
S
L
V
F
D
F
M
E
T
D
L
E
V
I
I
K
D
---
N
---
S
-
L
---
V
L
T
P
S
H
I
K
A
Y
M
L
M
T
L
Q
G
L
E
Y
L
H
Q
H
W
I
L
H
R
D
L
K
P
N
N
L
L
L
----
D
E
-
N
-
G
V
L
K
L
A
D
F
G
L
A
K
S
F
G
--
S
P
N
R
A
Y
T
H
Q
V
V
T
R
W
Y
R
A
P
E
L
L
F
G
A
R
M
Y
G
V
G
V
D
M
W
A
V
G
C
I
L
A
E
L
L
-
L
-
R
V
P
F
L
P
G
D
S
D
----
L
D
Q
L
T
R
I
F
E
T
L
G
T
P
T
E
E
Q
W
P
D
M
C
S
L
P
D
Y
V
--------
T
F
K
S
F
-
P
-
G
I
-
P
L
----
H
H
I
-
F
-
S
A
-
A
G
D
D
L
L
D
L
I
Q
G
L
F
L
F
N
P
C
A
R
I
T
A
T
Q
A
L
K
M
K
Y
F
S
N
R
P
G
P
T
P
G
C
Q
L
P
-
R
---
P
N
----------------------------------
132
HHSearch
68.91
36%
-106
- C1 -
4BGQ
3
CDKL5_HUMAN
A:
[11-300]
------------------------------------------------------------------------------------------------------------------------------------------
M
N
K
F
E
I
L
G
V
V
G
E
G
A
Y
G
V
V
L
K
C
R
H
K
--
E
T
H
E
I
V
A
I
K
K
F
K
---------
V
K
E
T
T
L
R
E
L
K
M
L
R
T
L
K
Q
E
N
I
V
E
L
K
E
A
F
--
R
-----
R
------
R
G
------
K
L
Y
L
V
F
E
Y
V
E
K
N
M
L
E
L
L
E
E
---
M
---
P
-
N
---
G
V
P
P
E
K
V
K
S
Y
I
Y
Q
L
I
K
A
I
H
W
C
H
K
N
D
I
V
H
R
D
I
K
P
E
N
L
L
I
----
S
H
-
N
-
D
V
L
K
L
C
D
F
G
F
A
R
N
L
S
--
E
----------
T
R
W
Y
R
S
P
E
L
L
L
G
-
A
P
Y
G
K
S
V
D
M
W
S
V
G
C
I
L
G
E
L
S
-
D
-
G
Q
P
L
F
P
G
E
S
E
----
I
D
Q
L
F
T
I
Q
K
V
L
G
P
L
P
S
E
Q
M
K
L
F
Y
S
N
P
R
F
H
----
G
L
--
R
F
P
A
V
-
N
H
P
Q
-
S
L
----
E
R
R
Y
L
-
G
I
-
L
N
S
V
L
L
D
L
M
K
N
L
L
K
L
D
P
A
D
R
Y
L
T
E
Q
C
L
N
H
P
T
F
Q
T
Q
R
L
-------------------------------------------------
131
HHSearch
67.06
35%
-113
- C1 -
2FST
3
MK14_HUMAN
X:
[25-319]
---------------------------------------------------------------------------------------------------------------------------------------
W
E
V
P
E
R
Y
Q
N
L
S
P
V
G
----
G
S
V
C
A
A
F
D
T
--
K
T
G
L
R
V
A
V
K
K
L
S
R
P
-
F
Q
-
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
--
T
-----
P
------
A
R
SLEEFN
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
------------
Q
-----
K
L
T
D
D
H
V
Q
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
----
N
E
-
D
-
C
E
L
K
I
L
D
--------------------
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
-
T
-
G
R
T
L
F
P
G
T
D
H
----
I
D
Q
L
K
L
I
L
R
L
V
G
T
P
G
A
E
L
L
K
K
I
S
S
E
S
-
A
R
----
N
Y
IQ
S
L
T
Q
M
-
P
-
K
M
-
N
F
----
A
N
V
-
F
-
I
G
-
A
N
P
L
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
P
V
A
D
-
P
---
Y
D
Q
S
L
E
S
R
D
L
L
I
D
E
W
-
K
S
L
T
Y
D
E
V
I
S
F
V
P
P
P
-----
133
HHSearch
66.23
36%
-114
- C1 -
4F6U
10
CDK8_HUMAN
A:
[27-339]
-------------------------------------------------------------------------------------------------------------------------------------------------
C
K
V
G
R
G
T
Y
G
H
V
Y
K
A
K
R
K
DG
K
D
D
K
D
Y
A
L
K
Q
I
E
G
-----
T
-
G
I
S
M
S
A
C
R
E
I
A
L
L
R
E
L
K
H
P
N
V
I
S
L
Q
K
V
F
L
S
H
-----
A
------
D
R
------
K
V
W
L
L
F
D
Y
A
E
H
D
L
W
H
I
I
K
F
---
H
---
R
-
A
S
KV
Q
L
P
R
G
M
V
K
S
L
L
Y
Q
I
L
D
G
I
H
Y
L
H
A
N
W
V
L
H
R
D
L
K
P
A
N
I
L
V
M
G
EG
P
E
-
R
-
G
R
V
K
I
A
D
M
G
F
----------------
V
V
T
F
W
Y
R
A
P
E
L
L
L
G
A
R
H
Y
T
K
A
I
D
I
W
A
I
G
C
I
F
A
E
L
L
-
T
-
S
E
P
I
F
H
C
R
Q
E
NPYH
H
D
Q
L
D
R
I
F
N
V
M
G
F
P
A
D
K
D
W
E
D
I
K
K
M
P
E
H
S
T
L
M
K
D
F
--
R
R
N
T
Y
-
T
-
N
C
-
S
L
I
K
Y
M
E
K
H
-
K
-
V
K
-
P
D
S
K
A
F
H
L
L
Q
K
L
L
T
M
D
P
I
K
R
I
T
S
E
Q
A
M
Q
D
P
Y
F
L
E
D
P
L
P
T
S
D
V
F
A
G
-
C
---
Q
I
P
Y
P
K
R
E
F
L
--------------------------
33
PsiBlast_CBE
61.62
53%
-2
- C1 -
4FKQ
2
CDK2_HUMAN
A:
[4-297]
------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
L
--------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
-----
T
------
E
N
------
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
---
A
L
T
---
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
-
E
-
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-----------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
-
R
R
A
L
F
P
G
D
S
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
----
P
---
S
F
P
K
W
-
A
-
R
Q
-
D
F
----
S
K
V
-
V
-
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
------------------------------------------
35
PsiBlast_CBE
61.40
53%
4
- C1 -
4FKO
1
CDK2_HUMAN
A:
[4-297]
------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
L
---------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
-----
T
------
E
N
------
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
---
A
L
T
---
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
-
E
-
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
--
V
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
-
R
R
A
L
F
P
G
D
S
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
----
P
---
S
F
P
K
W
-
A
-
R
Q
-
D
F
----
S
K
V
-
V
-
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
------------------------------------------
60
PsiBlast_CBE
59.66
53%
7
- C1 -
3IGG
1
CDK2_HUMAN
A:
[4-297]
------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
----------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
-----
T
------
E
N
------
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
---
A
L
T
---
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
-
E
-
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
--
V
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
-
R
R
A
L
F
P
G
D
S
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
----
P
---
S
F
P
K
W
-
A
-
R
Q
-
D
F
----
S
K
V
-
V
-
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
------------------------------------------
77
PsiBlast_CBE
52.30
53%
2
- C1 -
2W17
1
CDK2_HUMAN
A:
[4-297]
------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
-
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
-----
T
------
E
-------
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
---
A
L
T
---
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
-
E
-
G
A
I
K
L
A
D
F
G
L
A
---------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
-
R
R
A
L
F
P
G
D
S
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
----
P
---
S
F
P
K
W
-
A
-
R
Q
-
D
F
----
S
K
V
-
V
-
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
------------------------------------------
31
PsiBlast_CBE
52.09
53%
0
- C1 -
4FKV
2
CDK2_HUMAN
A:
[4-297]
------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
L
-------
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
-----
T
------
E
N
------
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
---
A
L
T
---
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
-
E
-
G
A
I
K
L
A
D
F
G
L
A
R
-------------
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
-
R
R
A
L
F
P
G
D
S
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
----
P
---
S
F
P
K
W
-
A
-
R
Q
-
D
F
----
S
K
V
-
V
-
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
------------------------------------------
40
PsiBlast_CBE
52.03
53%
3
- C1 -
4EK6
1
CDK2_HUMAN
A:
[4-297]
------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
------------
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
-----
T
------
E
N
------
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
---
A
L
T
---
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
-
E
-
G
A
I
K
L
A
D
F
G
L
A
R
A
------------
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
-
R
R
A
L
F
P
G
D
S
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
----
P
---
S
F
P
K
W
-
A
-
R
Q
-
D
F
----
S
K
V
-
V
-
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
------------------------------------------
53
PsiBlast_CBE
51.90
53%
-1
- C1 -
3SW7
1
CDK2_HUMAN
A:
[4-297]
------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
L
---------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
-----
T
------
E
N
------
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
---
A
L
T
---
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
-
E
-
G
A
I
K
L
A
D
F
G
L
A
---------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
-
R
R
A
L
F
P
G
D
S
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
----
P
---
S
F
P
K
W
-
A
-
R
Q
-
D
F
----
S
K
V
-
V
-
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
------------------------------------------
80
PsiBlast_CBE
51.81
53%
1
- C1 -
2VV9
1
CDK2_HUMAN
A:
[4-297]
------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
L
--------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
-----
T
------
E
N
------
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
---
A
L
T
---
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
-
E
-
G
A
I
K
L
A
D
F
G
L
A
---------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
-
R
R
A
L
F
P
G
D
S
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
----
P
---
S
F
P
K
W
-
A
-
R
Q
-
D
F
----
S
K
V
-
V
-
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
------------------------------------------
37
PsiBlast_CBE
51.56
53%
1
- C1 -
4FKJ
1
CDK2_HUMAN
A:
[4-297]
------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
-----------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
-----
T
------
E
N
------
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
---
A
L
T
---
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
-
E
-
G
A
I
K
L
A
D
F
G
L
A
R
A
-------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
-
R
R
A
L
F
P
G
D
S
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
----
P
---
S
F
P
K
W
-
A
-
R
Q
-
D
F
----
S
K
V
-
V
-
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
------------------------------------------
30
PsiBlast_CBE
51.27
53%
3
- C1 -
4FKW
2
CDK2_HUMAN
A:
[4-297]
------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
L
-------
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
-----
T
------
E
N
------
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
---
A
L
T
---
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
-
E
-
G
A
I
K
L
A
D
F
G
L
A
---------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
-
R
R
A
L
F
P
G
D
S
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
----
P
---
S
F
P
K
W
-
A
-
R
Q
-
D
F
----
S
K
V
-
V
-
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
------------------------------------------
38
PsiBlast_CBE
51.20
53%
8
- C1 -
4FKG
1
CDK2_HUMAN
A:
[4-297]
------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
-----------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
-----
T
------
E
N
------
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
---
A
L
T
---
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
-
E
-
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-----
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
-
R
R
A
L
F
P
G
D
S
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
----
P
---
S
F
P
K
W
-
A
-
R
Q
-
D
F
----
S
K
V
-
V
-
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
------------------------------------------
32
PsiBlast_CBE
50.93
53%
0
- C1 -
4FKR
2
CDK2_HUMAN
A:
[4-297]
------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
L
---------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
-----
T
------
E
N
------
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
---
A
L
T
---
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
-
E
-
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-----------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
-
R
R
A
L
F
P
G
D
S
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
----
P
---
S
F
P
K
W
-
A
-
R
Q
-
D
F
----
S
K
V
-
V
-
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
------------------------------------------
120
HHSearch
49.90
54%
7
- C1 -
4EK4
1
CDK2_HUMAN
A:
[4-291]
------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
-----------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
-----
T
------
E
N
------
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
---
A
-
L
T--
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
-
E
-
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
--
V
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
-
R
R
A
L
F
P
G
D
S
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
----
P
---
S
F
P
K
W
-
A
-
R
Q
-
D
F
----
S
K
V
-
V
-
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
--------------------------------------------
41
PsiBlast_CBE
49.86
53%
7
- C1 -
4EK5
1
CDK2_HUMAN
A:
[4-297]
------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
-----------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
-----
T
------
E
N
------
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
---
A
L
T
---
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
-
E
-
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
--
V
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
-
R
R
A
L
F
P
G
D
S
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
----
P
---
S
F
P
K
W
-
A
-
R
Q
-
D
F
----
S
K
V
-
V
-
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
------------------------------------------
42
PsiBlast_CBE
49.46
53%
9
- C1 -
4EK4
1
CDK2_HUMAN
A:
[4-297]
------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
-----------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
-----
T
------
E
N
------
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
---
A
L
T
---
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
-
E
-
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
--
V
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
-
R
R
A
L
F
P
G
D
S
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
----
P
---
S
F
P
K
W
-
A
-
R
Q
-
D
F
----
S
K
V
-
V
-
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
--------------------------------------------
61
PsiBlast_CBE
48.33
53%
7
- C1 -
3IG7
1
CDK2_HUMAN
A:
[4-297]
------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
----------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
-----
T
------
E
N
------
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
---
A
L
T
---
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
-
E
-
G
A
I
K
L
A
D
F
G
L
A
R
A
F
--------------
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
-
R
R
A
L
F
P
G
D
S
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
----
P
---
S
F
P
K
W
-
A
-
R
Q
-
D
F
----
S
K
V
-
V
-
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
------------------------------------------