@TOME V2.3
(Nov 2016)

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3D Common Core:

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Modeller Result :

Complexes Modeling
Templates Information:
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Values color: [ Good | Correct | Middling | Bad ]Sequence color : MutatedHelixStrandConserved

Query sequence : CDK19_HUMAN: (2015-10-04 )
MDYDFKAKLAAERERVEDLFEYEGCKVGRGTYGHVYKARRKDGKDEKEYALKQIEGTGISMSACREIALLRELKHPNVIALQKVFLSHSDRKVWLLFDYAEHDLWHIIKFHRASKANKKPMQLPRSMVKSLLYQILDGIHYLHANWVLHRDLKPANILVMGEGPERGRVKIADMGFARLFNSPLKPLADLDPVVVTFWYRAPELLLGARHYTKAIDIWAIGCIFAELLTSEPIFHCRQEDIKTSNPFHHDQLDRIFSVMGFPADKDWEDIRKMPEYPTLQKDFRRTTYANSSLIKYMEKHKVKPDSKVFLLLQKLLTMDPTKRITSEQALQDPYFQEDPLPTLDVFAGCQIPYPKREFLNEDDPEEKGDKNQQQQQNQHQQPTAPPQQAAAPPQAPPPQQNSTQTNGTAGGAGAGVGGTGAGLQHSQDSSLNQVPPNKKPRLGPSGANSGGPVMPSDYQHSSSRLNYQSSVQGSSQSQSTLGYSSSSQQSSQYHPSHQAHRY

Atome Classification :

(105 SA) .........10........20........30........40........50...----..----...60---.........70........80.......--.90---.........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......-230.......240.......250.......260.......270....-...280.....--..290........300..--.....310.......320.......330.....--..340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500
(Atome) (Ident) (Tito) (Num) (Ligand) (Uniprot) MDYDFKAKLAAERERVEDLFEYEGCKVGRGTYGHVYKARRKDGKDEKEYALKQI----EG----TGIS----MSACREIALLRELKHPNVIALQKVFLSH--SD----RKVWLLFDYAEHDLWHIIKFHRASKANKKPMQLPRSMVKSLLYQILDGIHYLHANWVLHRDLKPANILVMGEGPERGRVKIADMGFARLFNSPLKPLADLDPVVVTFWYRAPELLLGARHYTKAIDIWAIGCIFAELLT-SEPIFHCRQEDIKTSNPFHHDQLDRIFSVMGFPADKDWEDIRKMPEY-PTLQKDFRRTT--YAN-SSLIKYMEKHKVKP--DSKVFLLLQKLLTMDPTKRITSEQALQDPYFQE--DPLPTLDVFAGCQIPYPKREFLNEDDPEEKGDKNQQQQQNQHQQPTAPPQQAAAPPQAPPPQQNSTQTNGTAGGAGAGVGGTGAGLQHSQDSSLNQVPPNKKPRLGPSGANSGGPVMPSDYQHSSSRLNYQSSVQGSSQSQSTLGYSSSSQQSSQYHPSHQAHRY
2 PsiBlast_PDB 95.1087%-124 - C1 -4F6S CDK8_HUMAN A:[3-361] MDYDFKVKLSSERERVEDLFEYEGCKVGRGTYGHVYKAKRKDGKDDKDYALKQI----EG----TGIS----MSACREIALLRELKHPNVISLQKVFLSH--AD----RKVWLLFDYAEHDLWHIIKFHRAS--------LPRGMVKSLLYQILDGIHYLHANWVLHRDLKPANILVMGEGPERGRVKIADMGFA-----------------VTFWYRAPELLLGARHYTKAIDIWAIGCIFAELLT-SEPIFHCR-------NPYHHDQLDRIFNVMGFPADKDWEDIKKMPEH-STLMKDFRRNT--YTN-CSLIKYMEKHKVKP--DSKAFHLLQKLLTMDPIKRITSEQAMQDPYFLE--DPLPTSDVFAGCQIPYPKREFL-----------------------------------------------------------------------------------------------------------------------------------------------
5 PsiBlast_PDB 94.5887%-126 - C1 -4F70 CDK8_HUMAN A:[3-361] MDYDFKVKLSSERERVEDLFEYEGCKVGRGTYGHVYKAKRKDGKDDKDYALKQI----EG----TGIS----MSACREIALLRELKHPNVISLQKVFLSH--AD----RKVWLLFDYAEHDLWHIIKFHRASKA------LPRGMVKSLLYQILDGIHYLHANWVLHRDLKPANILVMGEGPERGRVKIADM--------------------VTFWYRAPELLLGARHYTKAIDIWAIGCIFAELLT-SEPIFHCR-------NPYHHDQLDRIFNVMGFPADKDWEDIKKMPEH-STLMKDFRRNT--YTN-CSLIKYMEKHKVKP--DSKAFHLLQKLLTMDPIKRITSEQAMQDPYFLE--DPLPTSDVFAGCQIPYPKREFL-----------------------------------------------------------------------------------------------------------------------------------------------
4 PsiBlast_PDB 94.4987%-121 - C1 -4F6W CDK8_HUMAN A:[3-361] MDYDFKVKLSSERERVEDLFEYEGCKVGRGTYGHVYKAKRKDGKDDKDYALKQI----EG----TGIS----MSACREIALLRELKHPNVISLQKVFLSH--AD----RKVWLLFDYAEHDLWHIIKFHRASK-----VQLPRGMVKSLLYQILDGIHYLHANWVLHRDLKPANILVMGEGPERGRVKIADMGFA------------------TFWYRAPELLLGARHYTKAIDIWAIGCIFAELLT-SEPIFHCRQ------NPYHHDQLDRIFNVMGFPADKDWEDIKKMPEH-STLMKDFRRNT--YTN-CSLIKYMEKHKVKP--DSKAFHLLQKLLTMDPIKRITSEQAMQDPYFLE--DPLPTSDVFAGCQIPYPKREFL-----------------------------------------------------------------------------------------------------------------------------------------------
8 PsiBlast_PDB 94.3887%-125 - C1 -4F7N CDK8_HUMAN A:[3-363] MDYDFKVKLSSERERVEDLFEYEGCKVGRGTYGHVYKAKRKDGKDDKDYALKQI----EG----TGIS----MSACREIALLRELKHPNVISLQKVFLSH--AD----RKVWLLFDYAEHDLWHIIKFHRAS------VQLPRGMVKSLLYQILDGIHYLHANWVLHRDLKPANILVMGEGPERGRVKIADMGF-----------------VVTFWYRAPELLLGARHYTKAIDIWAIGCIFAELLT-SEPIFHCRQE-----NPYHHDQLDRIFNVMGFPADKDWEDIKKMPEH-STLMKDFRRNT--YTN-CSLIKYMEKHKVKP--DSKAFHLLQKLLTMDPIKRITSEQAMQDPYFLE--DPLPTSDVFAGCQIPYPKREFLTE---------------------------------------------------------------------------------------------------------------------------------------------
9 PsiBlast_PDB 94.2987%-123 - C1 -4F7S CDK8_HUMAN A:[3-361] MDYDFKVKLSSERERVEDLFEYEGCKVGRGTYGHVYKAKRKDGKDDKDYALKQI----EG----TGIS----MSACREIALLRELKHPNVISLQKVFLSH--AD----RKVWLLFDYAEHDLWHIIKFHRASK------QLPRGMVKSLLYQILDGIHYLHANWVLHRDLKPANILVMGEGPERGRVKIADMGFARLFNSPLKP---------TFWYRAPELLLGARHYTKAIDIWAIGCIFAELLT-SEPIFHCR-----TSNPYHHDQLDRIFNVMGFPADKDWEDIKKMPEH-STLMKDFRRNT--YTN-CSLIKYMEKHKVKP--DSKAFHLLQKLLTMDPIKRITSEQAMQDPYFLE--DPLPTSDVFAGCQIPYPKREFL-----------------------------------------------------------------------------------------------------------------------------------------------
1 PsiBlast_PDB 93.9587%-130 - C1 -3RGF CDK8_HUMAN A:[3-355] MDYDFKVKLSSERERVEDLFEYEGCKVG-----HVYKAKRKDGKDDKDYALKQI----EG----TGIS----MSACREIALLRELKHPNVISLQKVFLSH--AD----RKVWLLFDYAEHDLWHIIKFHRASK-------LPRGMVKSLLYQILDGIHYLHANWVLHRDLKPANILVMGEGPERGRVKIADMGFAR----------------VTFWYRAPELLLGARHYTKAIDIWAIGCIFAELLT-SEPIFHCRQ------NPYHHDQLDRIFNVMGFPADKDWEDIKKMPEH-STLMKDFRRNT--YTN-CSLIKYMEKHKVKP--DSKAFHLLQKLLTMDPIKRITSEQAMQDPYFLE--DPLPTSDVFAGCQIPY-----------------------------------------------------------------------------------------------------------------------------------------------------
111 HHSearch 93.5288%-122 - C1 -4F6U CDK8_HUMAN A:[3-361] MDYDFKVKLSSERERVEDLFEYEGCKVGRGTYGHVYKAKRKDGKDDKDYALKQI----EG----TGIS----MSACREIALLRELKHPNVISLQKVFLSH--AD----RKVWLLFDYAEHDLWHIIKFHRASK-----VQLPRGMVKSLLYQILDGIHYLHANWVLHRDLKPANILVMGEGPERGRVKIADMGF-----------------VVTFWYRAPELLLGARHYTKAIDIWAIGCIFAELLT-SEPIFHCRQE-----NPYHHDQLDRIFNVMGFPADKDWEDIKKMPEH-STLMKDFRRNT--YTN-CSLIKYMEKHKVKP--DSKAFHLLQKLLTMDPIKRITSEQAMQDPYFLE--DPLPTSDVFAGCQIPYPKREFL-----------------------------------------------------------------------------------------------------------------------------------------------
7 PsiBlast_PDB 93.4487%-122 - C1 -4F7L CDK8_HUMAN A:[3-361] MDYDFKVKLSSERERVEDLFEYEGCKVGRGTYGHVYKAKRKDGKDDKDYALKQI----EG----TGIS----MSACREIALLRELKHPNVISLQKVFLSH--AD----RKVWLLFDYAEHDLWHIIKFHRAS-------QLPRGMVKSLLYQILDGIHYLHANWVLHRDLKPANILVMGEGPERGRVKIADMG--------------------TFWYRAPELLLGARHYTKAIDIWAIGCIFAELLT-SEPIFHCRQ------NPYHHDQLDRIFNVMGFPADKDWEDIKKMPEH-STLMKDFRRNT--YTN-CSLIKYMEKHKVKP--DSKAFHLLQKLLTMDPIKRITSEQAMQDPYFLE--DPLPTSDVFAGCQIPYPKREFL-----------------------------------------------------------------------------------------------------------------------------------------------
3 PsiBlast_PDB 93.2687%-122 - C1 -4F6U CDK8_HUMAN A:[3-361] MDYDFKVKLSSERERVEDLFEYEGCKVGRGTYGHVYKAKRKDGKDDKDYALKQI----EG----TGIS----MSACREIALLRELKHPNVISLQKVFLSH--AD----RKVWLLFDYAEHDLWHIIKFHRASK-----VQLPRGMVKSLLYQILDGIHYLHANWVLHRDLKPANILVMGEGPERGRVKIADMGF-----------------VVTFWYRAPELLLGARHYTKAIDIWAIGCIFAELLT-SEPIFHCRQE-----NPYHHDQLDRIFNVMGFPADKDWEDIKKMPEH-STLMKDFRRNT--YTN-CSLIKYMEKHKVKP--DSKAFHLLQKLLTMDPIKRITSEQAMQDPYFLE--DPLPTSDVFAGCQIPYPKREFL-----------------------------------------------------------------------------------------------------------------------------------------------
6 PsiBlast_PDB 92.1887%-126 - C1 -4F7J CDK8_HUMAN A:[3-361] MDYDFKVKLSSERERVEDLFEYEGCKVGRGTYGHVYKAKRKDGKDDKDYALKQI----EG----TGIS----MSACREIALLRELKHPNVISLQKVFLSH--AD----RKVWLLFDYAEHDLWHIIKFHR---------QLPRGMVKSLLYQILDGIHYLHANWVLHRDLKPANILVMGEGPERGRVKIADMGF------------------VTFWYRAPELLLGARHYTKAIDIWAIGCIFAELLT-SEPIFHCRQ------NPYHHDQLDRIFNVMGFPADKDWEDIKKMPEH-STLMKDFRRNT--YTN-CSLIKYMEKHKVKP--DSKAFHLLQKLLTMDPIKRITSEQAMQDPYFLE--DPLPTSDVFAGCQIPYPKREFL-----------------------------------------------------------------------------------------------------------------------------------------------
27 PsiBlast_CBE 69.5240%-107 - C1 -3S00 CDK2_HUMAN A:[17-304] -------------------------KIGEGTYGVVYKARNKLTGEV--VALKKIR----T----EGVP----STAIREISLLKELNHPNIVKLLDVI--H--TE----NKLYLVFEFLHQDL---KKFMDASALTGIPLPL----IKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGA----IKLADFGLARAFGVPVRTYTH---EVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVT-RRALFPGDSEI---------DQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQ---------------DFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL-------------------------------------------------------------------------------------------------------------------------------------------------------------
71 PsiBlast_CBE 69.4140%-104 - C1 -3QZH CDK2_HUMAN A:[17-304] -------------------------KIGEGTYGVVYKARNKLTGEV--VALKKIR----T----EGVP----STAIREISLLKELNHPNIVKLLDVI--H--TE----NKLYLVFEFLHQDL---KKFMDASALTGIPLPL----IKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGA----IKLADFGLARAFGVPVRTYTH---EVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVT-RRALFPGDSEI---------DQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQ---------------DFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL-------------------------------------------------------------------------------------------------------------------------------------------------------------
65 PsiBlast_CBE 69.2240%-105 - C1 -3R6X CDK2_HUMAN A:[17-304] -------------------------KIGEGTYGVVYKARNKLTGEV--VALKKIR----T----EGVP----STAIREISLLKELNHPNIVKLLDVI--H--TE----NKLYLVFEFLHQDL---KKFMDASALTGIPLPL----IKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGA----IKLADFGLARAFGVPVRTYTH---EVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVT-RRALFPGDSEI---------DQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQ---------------DFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL-------------------------------------------------------------------------------------------------------------------------------------------------------------
98 PsiBlast_CBE 69.1540%-104 - C1 -3PJ8 CDK2_HUMAN A:[10-297] -------------------------KIGEGTYGVVYKARNKLTGEV--VALKKIR---ET----EGVP----STAIREISLLKELNHPNIVKLLDVI--H--TE----NKLYLVFEFLHQDL---KKFMDASALTGIPLPL----IKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGA----IKLADFGLARAFGV-----------VVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVT-RRALFPGDSEI---------DQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQ---------------DFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL-------------------------------------------------------------------------------------------------------------------------------------------------------------
57 PsiBlast_CBE 69.0840%-105 - C1 -3R83 CDK2_HUMAN A:[17-304] -------------------------KIGEGTYGVVYKARNKLTGEV--VALKKIR----T----EGVP----STAIREISLLKELNHPNIVKLLDVI--H--TE----NKLYLVFEFLHQDL---KKFMDASALTGIPLPL----IKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGA----IKLADFGLARAFGVPVRTYTH---EVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVT-RRALFPGDSEI---------DQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQ---------------DFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL-------------------------------------------------------------------------------------------------------------------------------------------------------------
67 PsiBlast_CBE 69.0640%-103 - C1 -3R1Y CDK2_HUMAN A:[17-304] -------------------------KIGEGTYGVVYKARNKLTGEV--VALKKIR----T----EGVP----STAIREISLLKELNHPNIVKLLDVI--H--TE----NKLYLVFEFLHQDL---KKFMDASALTGIPLPL----IKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGA----IKLADFGLARAFGVPVRTYTH---EVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVT-RRALFPGDSEI---------DQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQ---------------DFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL-------------------------------------------------------------------------------------------------------------------------------------------------------------
93 PsiBlast_CBE 68.8840%-103 - C1 -3QQH CDK2_HUMAN A:[17-304] -------------------------KIGEGTYGVVYKARNKLTGEV--VALKKIR----T----EGVP----STAIREISLLKELNHPNIVKLLDVI--H--TE----NKLYLVFEFLHQDL---KKFMDASALTGIPLPL----IKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGA----IKLADFGLARAFGVPVRTYTH---EVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVT-RRALFPGDSEI---------DQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQ---------------DFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL-------------------------------------------------------------------------------------------------------------------------------------------------------------
68 PsiBlast_CBE 68.8840%-104 - C1 -3R1S CDK2_HUMAN A:[17-304] -------------------------KIGEGTYGVVYKARNKLTGEV--VALKKIR----T----EGVP----STAIREISLLKELNHPNIVKLLDVI--H--TE----NKLYLVFEFLHQDL---KKFMDASALTGIPLPL----IKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGA----IKLADFGLARAFGVPVRTYTH---EVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVT-RRALFPGDSEI---------DQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQ---------------DFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL-------------------------------------------------------------------------------------------------------------------------------------------------------------
63 PsiBlast_CBE 68.8040%-105 - C1 -3R73 CDK2_HUMAN A:[17-304] -------------------------KIGEGTYGVVYKARNKLTGEV--VALKKIR----T----EGVP----STAIREISLLKELNHPNIVKLLDVI--H--TE----NKLYLVFEFLHQDL---KKFMDASALTGIPLPL----IKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGA----IKLADFGLARAFGVPVRTYTH---EVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVT-RRALFPGDSEI---------DQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQ---------------DFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL-------------------------------------------------------------------------------------------------------------------------------------------------------------
51 PsiBlast_CBE 68.8040%-107 - C1 -3R8Z CDK2_HUMAN A:[17-304] -------------------------KIGEGTYGVVYKARNKLTGEV--VALKKIR----T----EGVP----STAIREISLLKELNHPNIVKLLDVI--H--TE----NKLYLVFEFLHQDL---KKFMDASALTGIPLPL----IKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGA----IKLADFGLARAFGVP----TH---EVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVT-RRALFPGDSEI---------DQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQ---------------DFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL-------------------------------------------------------------------------------------------------------------------------------------------------------------
66 PsiBlast_CBE 68.7640%-102 - C1 -3R28 CDK2_HUMAN A:[17-304] -------------------------KIGEGTYGVVYKARNKLTGEV--VALKKIR----T----EGVP----STAIREISLLKELNHPNIVKLLDVI--H--TE----NKLYLVFEFLHQDL---KKFMDASALTGIPLPL----IKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGA----IKLADFGLARAFGVPVRTYTH---EVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVT-RRALFPGDSEI---------DQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQ---------------DFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL-------------------------------------------------------------------------------------------------------------------------------------------------------------
92 PsiBlast_CBE 68.6140% -99 - C1 -3QQJ CDK2_HUMAN A:[17-304] -------------------------KIGEGTYGVVYKARNKLTGEV--VALKKIR----T----EGVP----STAIREISLLKELNHPNIVKLLDVI--H--TE----NKLYLVFEFLHQDL---KKFMDASALTGIPLPL----IKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGA----IKLADFGLARAFGVPVRTYTH---EVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVT-RRALFPGDSEI---------DQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQ---------------DFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL-------------------------------------------------------------------------------------------------------------------------------------------------------------
60 PsiBlast_CBE 68.6140%-104 - C1 -3R7U CDK2_HUMAN A:[17-304] -------------------------KIGEGTYGVVYKARNKLTGEV--VALKKIR------------P----STAIREISLLKELNHPNIVKLLDVI--H--TE----NKLYLVFEFLHQDL---KKFMDASALTGIPLPL----IKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGA----IKLADFGLARAFGV-----------VVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVT-RRALFPGDSEI---------DQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQ---------------DFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL-------------------------------------------------------------------------------------------------------------------------------------------------------------
17 PsiBlast_PDB 68.5840%-103 - C1 -3PY0 CDK2_HUMAN A:[17-304] -------------------------KIGEGTYGVVYKARNKLTGEV--VALKKIR----T----EGVP----STAIREISLLKELNHPNIVKLLDVI--H--TE----NKLYLVFEFLHQDL---KKFMDASALTGIPLPL----IKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGA----IKLADFGLARAFGVPVRTYTH---EVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVT-RRALFPGDSEI---------DQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQ---------------DFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL-------------------------------------------------------------------------------------------------------------------------------------------------------------