@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : CDK19_HUMAN: (2015-10-04 )
MDYDFKAKLAAERERVEDLFEYEGCKVGRGTYGHVYKARRKDGKDEKEYALKQIEGTGISMSACREIALLRELKHPNVIALQKVFLSHSDRKVWLLFDYAEHDLWHIIKFHRASKANKKPMQLPRSMVKSLLYQILDGIHYLHANWVLHRDLKPANILVMGEGPERGRVKIADMGFARLFNSPLKPLADLDPVVVTFWYRAPELLLGARHYTKAIDIWAIGCIFAELLTSEPIFHCRQEDIKTSNPFHHDQLDRIFSVMGFPADKDWEDIRKMPEYPTLQKDFRRTTYANSSLIKYMEKHKVKPDSKVFLLLQKLLTMDPTKRITSEQALQDPYFQEDPLPTLDVFAGCQIPYPKREFLNEDDPEEKGDKNQQQQQNQHQQPTAPPQQAAAPPQAPPPQQNSTQTNGTAGGAGAGVGGTGAGLQHSQDSSLNQVPPNKKPRLGPSGANSGGPVMPSDYQHSSSRLNYQSSVQGSSQSQSTLGYSSSSQQSSQYHPSHQAHRY
Atome Classification :
(105 SA)
.........10........20........30........40........50...----..----...60---.........70........80.......--.90---.........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......-230.......240.......250.......260.......270....-...280.....--..290........300..--.....310.......320.......330.....--..340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MDYD
F
K
A
K
L
A
A
E
R
E
R
V
E
D
L
F
E
YEGCKVGRGTYG
H
V
Y
K
A
RRKDGK
D
E
K
E
Y
A
L
K
Q
I----EG----TGI
S
----
M
S
A
C
R
E
I
A
L
L
R
E
LKHP
N
V
I
A
L
Q
K
V
F
LSH--SD----
R
K
V
W
L
L
F
DYAE
H
D
L
W
H
I
I
K
F
H
RASKANKK
P
M
Q
L
P
R
S
M
V
K
S
L
L
Y
Q
I
L
D
G
I
H
Y
L
HA
N
W
V
L
HRDLKPA
N
I
L
V
MGEGPERG
R
V
K
I
A
D
M
G
F
A
R
L
FNSPLKPLADLD
P
V
V
V
T
F
W
YR
A
P
E
L
L
L
GARH
Y
T
K
A
I
D
I
W
A
I
G
C
I
F
A
E
L
LT-SEP
I
F
H
C
R
QEDIKTSNPF
H
H
D
Q
L
D
R
I
F
S
V
MGFPADK
D
W
E
D
I
R
KMPEY-P
T
L
Q
K
D
F
R
R
TT--YA
N
-
S
S
L
I
K
Y
M
E
K
HKVKP--D
S
K
V
F
L
L
L
Q
K
L
LTMDPTKRI
T
S
E
Q
ALQDPYFQE--DPL
P
T
L
D
V
FAGCQIPY
P
K
R
E
FLNEDDPEEKGD
K
N
Q
Q
Q
Q
Q
N
QHQQPTAPPQQAAAPPQAPPPQQNSTQTNGTAGGAGAGVGGTGAGLQHSQDSSLNQVPPNKKPRLGPSGANSGGPVMPSDYQHSSSRLNYQSSVQGSSQSQSTLGYSSSSQQSSQYHPSHQAHRY
2
PsiBlast_PDB
95.10
87%
-124
- C1 -
4F6S
6
CDK8_HUMAN
A:
[3-361]
M
D
Y
D
F
K
V
K
L
S
S
E
R
E
R
V
E
D
L
F
E
Y
E
G
C
K
V
G
R
G
T
Y
G
H
V
Y
K
A
K
R
K
D
G
K
D
D
K
D
Y
A
L
K
Q
I
----
E
G
----
T
G
I
S
----
M
S
A
C
R
E
I
A
L
L
R
E
L
K
H
P
N
V
I
S
L
Q
K
V
F
L
S
H
--
A
D
----
R
K
V
W
L
L
F
D
Y
A
E
H
D
L
W
H
I
I
K
F
H
R
A
S
--------
L
P
R
G
M
V
K
S
L
L
Y
Q
I
L
D
G
I
H
Y
L
H
A
N
W
V
L
H
R
D
L
K
P
A
N
I
L
V
M
G
E
G
P
E
R
G
R
V
K
I
A
D
M
G
F
A
-----------------
V
T
F
W
Y
R
A
P
E
L
L
L
G
A
R
H
Y
T
K
A
I
D
I
W
A
I
G
C
I
F
A
E
L
L
T
-
S
E
P
I
F
H
C
R
-------
N
P
Y
H
H
D
Q
L
D
R
I
F
N
V
M
G
F
P
A
D
K
D
W
E
D
I
K
K
M
P
E
H
-
S
T
L
M
K
D
F
R
R
N
T
--
Y
T
N
-
C
S
L
I
K
Y
M
E
K
H
K
V
K
P
--
D
S
K
A
F
H
L
L
Q
K
L
L
T
M
D
P
I
K
R
I
T
S
E
Q
A
M
Q
D
P
Y
F
L
E
--
D
P
L
P
T
S
D
V
F
A
G
C
Q
I
P
Y
P
K
R
E
F
L
-----------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
94.58
87%
-126
- C1 -
4F70
1
CDK8_HUMAN
A:
[3-361]
M
D
Y
D
F
K
V
K
L
S
S
E
R
E
R
V
E
D
L
F
E
Y
E
G
C
K
V
G
R
G
T
Y
G
H
V
Y
K
A
K
R
K
D
G
K
D
D
K
D
Y
A
L
K
Q
I
----
E
G
----
T
G
I
S
----
M
S
A
C
R
E
I
A
L
L
R
E
L
K
H
P
N
V
I
S
L
Q
K
V
F
L
S
H
--
A
D
----
R
K
V
W
L
L
F
D
Y
A
E
H
D
L
W
H
I
I
K
F
H
R
A
S
K
A
------
L
P
R
G
M
V
K
S
L
L
Y
Q
I
L
D
G
I
H
Y
L
H
A
N
W
V
L
H
R
D
L
K
P
A
N
I
L
V
M
G
E
G
P
E
R
G
R
V
K
I
A
D
M
--------------------
V
T
F
W
Y
R
A
P
E
L
L
L
G
A
R
H
Y
T
K
A
I
D
I
W
A
I
G
C
I
F
A
E
L
L
T
-
S
E
P
I
F
H
C
R
-------
N
P
Y
H
H
D
Q
L
D
R
I
F
N
V
M
G
F
P
A
D
K
D
W
E
D
I
K
K
M
P
E
H
-
S
T
L
M
K
D
F
R
R
N
T
--
Y
T
N
-
C
S
L
I
K
Y
M
E
K
H
K
V
K
P
--
D
S
K
A
F
H
L
L
Q
K
L
L
T
M
D
P
I
K
R
I
T
S
E
Q
A
M
Q
D
P
Y
F
L
E
--
D
P
L
P
T
S
D
V
F
A
G
C
Q
I
P
Y
P
K
R
E
F
L
-----------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
94.49
87%
-121
- C1 -
4F6W
10
CDK8_HUMAN
A:
[3-361]
M
D
Y
D
F
K
V
K
L
S
S
E
R
E
R
V
E
D
L
F
E
Y
E
G
C
K
V
G
R
G
T
Y
G
H
V
Y
K
A
K
R
K
D
G
K
D
D
K
D
Y
A
L
K
Q
I
----
E
G
----
T
G
I
S
----
M
S
A
C
R
E
I
A
L
L
R
E
L
K
H
P
N
V
I
S
L
Q
K
V
F
L
S
H
--
A
D
----
R
K
V
W
L
L
F
D
Y
A
E
H
D
L
W
H
I
I
K
F
H
R
A
S
K
-----
V
Q
L
P
R
G
M
V
K
S
L
L
Y
Q
I
L
D
G
I
H
Y
L
H
A
N
W
V
L
H
R
D
L
K
P
A
N
I
L
V
M
G
E
G
P
E
R
G
R
V
K
I
A
D
M
G
F
A
------------------
T
F
W
Y
R
A
P
E
L
L
L
G
A
R
H
Y
T
K
A
I
D
I
W
A
I
G
C
I
F
A
E
L
L
T
-
S
E
P
I
F
H
C
R
Q
------
N
P
Y
H
H
D
Q
L
D
R
I
F
N
V
M
G
F
P
A
D
K
D
W
E
D
I
K
K
M
P
E
H
-
S
T
L
M
K
D
F
R
R
N
T
--
Y
T
N
-
C
S
L
I
K
Y
M
E
K
H
K
V
K
P
--
D
S
K
A
F
H
L
L
Q
K
L
L
T
M
D
P
I
K
R
I
T
S
E
Q
A
M
Q
D
P
Y
F
L
E
--
D
P
L
P
T
S
D
V
F
A
G
C
Q
I
P
Y
P
K
R
E
F
L
-----------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
94.38
87%
-125
- C1 -
4F7N
2
CDK8_HUMAN
A:
[3-363]
M
D
Y
D
F
K
V
K
L
S
S
E
R
E
R
V
E
D
L
F
E
Y
E
G
C
K
V
G
R
G
T
Y
G
H
V
Y
K
A
K
R
K
D
G
K
D
D
K
D
Y
A
L
K
Q
I
----
E
G
----
T
G
I
S
----
M
S
A
C
R
E
I
A
L
L
R
E
L
K
H
P
N
V
I
S
L
Q
K
V
F
L
S
H
--
A
D
----
R
K
V
W
L
L
F
D
Y
A
E
H
D
L
W
H
I
I
K
F
H
R
A
S
------
V
Q
L
P
R
G
M
V
K
S
L
L
Y
Q
I
L
D
G
I
H
Y
L
H
A
N
W
V
L
H
R
D
L
K
P
A
N
I
L
V
M
G
E
G
P
E
R
G
R
V
K
I
A
D
M
G
F
-----------------
V
V
T
F
W
Y
R
A
P
E
L
L
L
G
A
R
H
Y
T
K
A
I
D
I
W
A
I
G
C
I
F
A
E
L
L
T
-
S
E
P
I
F
H
C
R
Q
E
-----
N
P
Y
H
H
D
Q
L
D
R
I
F
N
V
M
G
F
P
A
D
K
D
W
E
D
I
K
K
M
P
E
H
-
S
T
L
M
K
D
F
R
R
N
T
--
Y
T
N
-
C
S
L
I
K
Y
M
E
K
H
K
V
K
P
--
D
S
K
A
F
H
L
L
Q
K
L
L
T
M
D
P
I
K
R
I
T
S
E
Q
A
M
Q
D
P
Y
F
L
E
--
D
P
L
P
T
S
D
V
F
A
G
C
Q
I
P
Y
P
K
R
E
F
L
T
E
---------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
94.29
87%
-123
- C1 -
4F7S
8
CDK8_HUMAN
A:
[3-361]
M
D
Y
D
F
K
V
K
L
S
S
E
R
E
R
V
E
D
L
F
E
Y
E
G
C
K
V
G
R
G
T
Y
G
H
V
Y
K
A
K
R
K
D
G
K
D
D
K
D
Y
A
L
K
Q
I
----
E
G
----
T
G
I
S
----
M
S
A
C
R
E
I
A
L
L
R
E
L
K
H
P
N
V
I
S
L
Q
K
V
F
L
S
H
--
A
D
----
R
K
V
W
L
L
F
D
Y
A
E
H
D
L
W
H
I
I
K
F
H
R
A
S
K
------
Q
L
P
R
G
M
V
K
S
L
L
Y
Q
I
L
D
G
I
H
Y
L
H
A
N
W
V
L
H
R
D
L
K
P
A
N
I
L
V
M
G
E
G
P
E
R
G
R
V
K
I
A
D
M
G
F
A
R
L
F
N
S
P
L
K
P
---------
T
F
W
Y
R
A
P
E
L
L
L
G
A
R
H
Y
T
K
A
I
D
I
W
A
I
G
C
I
F
A
E
L
L
T
-
S
E
P
I
F
H
C
R
-----
T
S
N
P
Y
H
H
D
Q
L
D
R
I
F
N
V
M
G
F
P
A
D
K
D
W
E
D
I
K
K
M
P
E
H
-
S
T
L
M
K
D
F
R
R
N
T
--
Y
T
N
-
C
S
L
I
K
Y
M
E
K
H
K
V
K
P
--
D
S
K
A
F
H
L
L
Q
K
L
L
T
M
D
P
I
K
R
I
T
S
E
Q
A
M
Q
D
P
Y
F
L
E
--
D
P
L
P
T
S
D
V
F
A
G
C
Q
I
P
Y
P
K
R
E
F
L
-----------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
93.95
87%
-130
- C1 -
3RGF
6
CDK8_HUMAN
A:
[3-355]
M
D
Y
D
F
K
V
K
L
S
S
E
R
E
R
V
E
D
L
F
E
Y
E
G
C
K
V
G
-----
H
V
Y
K
A
K
R
K
D
G
K
D
D
K
D
Y
A
L
K
Q
I
----
E
G
----
T
G
I
S
----
M
S
A
C
R
E
I
A
L
L
R
E
L
K
H
P
N
V
I
S
L
Q
K
V
F
L
S
H
--
A
D
----
R
K
V
W
L
L
F
D
Y
A
E
H
D
L
W
H
I
I
K
F
H
R
A
S
K
-------
L
P
R
G
M
V
K
S
L
L
Y
Q
I
L
D
G
I
H
Y
L
H
A
N
W
V
L
H
R
D
L
K
P
A
N
I
L
V
M
G
E
G
P
E
R
G
R
V
K
I
A
D
M
G
F
A
R
----------------
V
T
F
W
Y
R
A
P
E
L
L
L
G
A
R
H
Y
T
K
A
I
D
I
W
A
I
G
C
I
F
A
E
L
L
T
-
S
E
P
I
F
H
C
R
Q
------
N
P
Y
H
H
D
Q
L
D
R
I
F
N
V
M
G
F
P
A
D
K
D
W
E
D
I
K
K
M
P
E
H
-
S
T
L
M
K
D
F
R
R
N
T
--
Y
T
N
-
C
S
L
I
K
Y
M
E
K
H
K
V
K
P
--
D
S
K
A
F
H
L
L
Q
K
L
L
T
M
D
P
I
K
R
I
T
S
E
Q
A
M
Q
D
P
Y
F
L
E
--
D
P
L
P
T
S
D
V
F
A
G
C
Q
I
P
Y
-----------------------------------------------------------------------------------------------------------------------------------------------------
111
HHSearch
93.52
88%
-122
- C1 -
4F6U
10
CDK8_HUMAN
A:
[3-361]
M
D
Y
D
F
K
V
K
L
S
S
E
R
E
R
V
E
D
L
F
E
Y
E
G
C
K
V
G
R
G
T
Y
G
H
V
Y
K
A
K
R
K
D
G
K
D
D
K
D
Y
A
L
K
Q
I
----
E
G
----
T
G
I
S
----
M
S
A
C
R
E
I
A
L
L
R
E
L
K
H
P
N
V
I
S
L
Q
K
V
F
L
S
H
--
A
D
----
R
K
V
W
L
L
F
D
Y
A
E
H
D
L
W
H
I
I
K
F
H
R
A
S
K
-----
V
Q
L
P
R
G
M
V
K
S
L
L
Y
Q
I
L
D
G
I
H
Y
L
H
A
N
W
V
L
H
R
D
L
K
P
A
N
I
L
V
M
G
E
G
P
E
R
G
R
V
K
I
A
D
M
G
F
-----------------
V
V
T
F
W
Y
R
A
P
E
L
L
L
G
A
R
H
Y
T
K
A
I
D
I
W
A
I
G
C
I
F
A
E
L
L
T
-
S
E
P
I
F
H
C
R
Q
E
-----
N
P
Y
H
H
D
Q
L
D
R
I
F
N
V
M
G
F
P
A
D
K
D
W
E
D
I
K
K
M
P
E
H
-
S
T
L
M
K
D
F
R
R
N
T
--
Y
T
N
-
C
S
L
I
K
Y
M
E
K
H
K
V
K
P
--
D
S
K
A
F
H
L
L
Q
K
L
L
T
M
D
P
I
K
R
I
T
S
E
Q
A
M
Q
D
P
Y
F
L
E
--
D
P
L
P
T
S
D
V
F
A
G
C
Q
I
P
Y
P
K
R
E
F
L
-----------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
93.44
87%
-122
- C1 -
4F7L
1
CDK8_HUMAN
A:
[3-361]
M
D
Y
D
F
K
V
K
L
S
S
E
R
E
R
V
E
D
L
F
E
Y
E
G
C
K
V
G
R
G
T
Y
G
H
V
Y
K
A
K
R
K
D
G
K
D
D
K
D
Y
A
L
K
Q
I
----
E
G
----
T
G
I
S
----
M
S
A
C
R
E
I
A
L
L
R
E
L
K
H
P
N
V
I
S
L
Q
K
V
F
L
S
H
--
A
D
----
R
K
V
W
L
L
F
D
Y
A
E
H
D
L
W
H
I
I
K
F
H
R
A
S
-------
Q
L
P
R
G
M
V
K
S
L
L
Y
Q
I
L
D
G
I
H
Y
L
H
A
N
W
V
L
H
R
D
L
K
P
A
N
I
L
V
M
G
E
G
P
E
R
G
R
V
K
I
A
D
M
G
--------------------
T
F
W
Y
R
A
P
E
L
L
L
G
A
R
H
Y
T
K
A
I
D
I
W
A
I
G
C
I
F
A
E
L
L
T
-
S
E
P
I
F
H
C
R
Q
------
N
P
Y
H
H
D
Q
L
D
R
I
F
N
V
M
G
F
P
A
D
K
D
W
E
D
I
K
K
M
P
E
H
-
S
T
L
M
K
D
F
R
R
N
T
--
Y
T
N
-
C
S
L
I
K
Y
M
E
K
H
K
V
K
P
--
D
S
K
A
F
H
L
L
Q
K
L
L
T
M
D
P
I
K
R
I
T
S
E
Q
A
M
Q
D
P
Y
F
L
E
--
D
P
L
P
T
S
D
V
F
A
G
C
Q
I
P
Y
P
K
R
E
F
L
-----------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
93.26
87%
-122
- C1 -
4F6U
10
CDK8_HUMAN
A:
[3-361]
M
D
Y
D
F
K
V
K
L
S
S
E
R
E
R
V
E
D
L
F
E
Y
E
G
C
K
V
G
R
G
T
Y
G
H
V
Y
K
A
K
R
K
D
G
K
D
D
K
D
Y
A
L
K
Q
I
----
E
G
----
T
G
I
S
----
M
S
A
C
R
E
I
A
L
L
R
E
L
K
H
P
N
V
I
S
L
Q
K
V
F
L
S
H
--
A
D
----
R
K
V
W
L
L
F
D
Y
A
E
H
D
L
W
H
I
I
K
F
H
R
A
S
K
-----
V
Q
L
P
R
G
M
V
K
S
L
L
Y
Q
I
L
D
G
I
H
Y
L
H
A
N
W
V
L
H
R
D
L
K
P
A
N
I
L
V
M
G
E
G
P
E
R
G
R
V
K
I
A
D
M
G
F
-----------------
V
V
T
F
W
Y
R
A
P
E
L
L
L
G
A
R
H
Y
T
K
A
I
D
I
W
A
I
G
C
I
F
A
E
L
L
T
-
S
E
P
I
F
H
C
R
Q
E
-----
N
P
Y
H
H
D
Q
L
D
R
I
F
N
V
M
G
F
P
A
D
K
D
W
E
D
I
K
K
M
P
E
H
-
S
T
L
M
K
D
F
R
R
N
T
--
Y
T
N
-
C
S
L
I
K
Y
M
E
K
H
K
V
K
P
--
D
S
K
A
F
H
L
L
Q
K
L
L
T
M
D
P
I
K
R
I
T
S
E
Q
A
M
Q
D
P
Y
F
L
E
--
D
P
L
P
T
S
D
V
F
A
G
C
Q
I
P
Y
P
K
R
E
F
L
-----------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
92.18
87%
-126
- C1 -
4F7J
3
CDK8_HUMAN
A:
[3-361]
M
D
Y
D
F
K
V
K
L
S
S
E
R
E
R
V
E
D
L
F
E
Y
E
G
C
K
V
G
R
G
T
Y
G
H
V
Y
K
A
K
R
K
D
G
K
D
D
K
D
Y
A
L
K
Q
I
----
E
G
----
T
G
I
S
----
M
S
A
C
R
E
I
A
L
L
R
E
L
K
H
P
N
V
I
S
L
Q
K
V
F
L
S
H
--
A
D
----
R
K
V
W
L
L
F
D
Y
A
E
H
D
L
W
H
I
I
K
F
H
R
---------
Q
L
P
R
G
M
V
K
S
L
L
Y
Q
I
L
D
G
I
H
Y
L
H
A
N
W
V
L
H
R
D
L
K
P
A
N
I
L
V
M
G
E
G
P
E
R
G
R
V
K
I
A
D
M
G
F
------------------
V
T
F
W
Y
R
A
P
E
L
L
L
G
A
R
H
Y
T
K
A
I
D
I
W
A
I
G
C
I
F
A
E
L
L
T
-
S
E
P
I
F
H
C
R
Q
------
N
P
Y
H
H
D
Q
L
D
R
I
F
N
V
M
G
F
P
A
D
K
D
W
E
D
I
K
K
M
P
E
H
-
S
T
L
M
K
D
F
R
R
N
T
--
Y
T
N
-
C
S
L
I
K
Y
M
E
K
H
K
V
K
P
--
D
S
K
A
F
H
L
L
Q
K
L
L
T
M
D
P
I
K
R
I
T
S
E
Q
A
M
Q
D
P
Y
F
L
E
--
D
P
L
P
T
S
D
V
F
A
G
C
Q
I
P
Y
P
K
R
E
F
L
-----------------------------------------------------------------------------------------------------------------------------------------------
27
PsiBlast_CBE
69.52
40%
-107
- C1 -
3S00
1
CDK2_HUMAN
A:
[17-304]
-------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
--
V
A
L
K
K
I
R----
T
----
E
G
V
P
----
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
--
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------
71
PsiBlast_CBE
69.41
40%
-104
- C1 -
3QZH
2
CDK2_HUMAN
A:
[17-304]
-------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
--
V
A
L
K
K
I
R----
T
----
E
G
V
P
----
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
--
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------
65
PsiBlast_CBE
69.22
40%
-105
- C1 -
3R6X
2
CDK2_HUMAN
A:
[17-304]
-------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
--
V
A
L
K
K
I
R----
T
----
E
G
V
P
----
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
--
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------
98
PsiBlast_CBE
69.15
40%
-104
- C1 -
3PJ8
1
CDK2_HUMAN
A:
[10-297]
-------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
--
V
A
L
K
K
I
R---
E
T
----
E
G
V
P
----
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
--
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
-----------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------
57
PsiBlast_CBE
69.08
40%
-105
- C1 -
3R83
2
CDK2_HUMAN
A:
[17-304]
-------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
--
V
A
L
K
K
I
R----
T
----
E
G
V
P
----
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
--
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------
67
PsiBlast_CBE
69.06
40%
-103
- C1 -
3R1Y
2
CDK2_HUMAN
A:
[17-304]
-------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
--
V
A
L
K
K
I
R----
T
----
E
G
V
P
----
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
--
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------
93
PsiBlast_CBE
68.88
40%
-103
- C1 -
3QQH
5
CDK2_HUMAN
A:
[17-304]
-------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
--
V
A
L
K
K
I
R----
T
----
E
G
V
P
----
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
--
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------
68
PsiBlast_CBE
68.88
40%
-104
- C1 -
3R1S
2
CDK2_HUMAN
A:
[17-304]
-------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
--
V
A
L
K
K
I
R----
T
----
E
G
V
P
----
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
--
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------
63
PsiBlast_CBE
68.80
40%
-105
- C1 -
3R73
2
CDK2_HUMAN
A:
[17-304]
-------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
--
V
A
L
K
K
I
R----
T
----
E
G
V
P
----
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
--
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------
51
PsiBlast_CBE
68.80
40%
-107
- C1 -
3R8Z
1
CDK2_HUMAN
A:
[17-304]
-------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
--
V
A
L
K
K
I
R----
T
----
E
G
V
P
----
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
--
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
----
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------
66
PsiBlast_CBE
68.76
40%
-102
- C1 -
3R28
2
CDK2_HUMAN
A:
[17-304]
-------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
--
V
A
L
K
K
I
R----
T
----
E
G
V
P
----
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
--
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------
92
PsiBlast_CBE
68.61
40%
-99
- C1 -
3QQJ
2
CDK2_HUMAN
A:
[17-304]
-------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
--
V
A
L
K
K
I
R----
T
----
E
G
V
P
----
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
--
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------
60
PsiBlast_CBE
68.61
40%
-104
- C1 -
3R7U
2
CDK2_HUMAN
A:
[17-304]
-------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
--
V
A
L
K
K
I
R------------
P
----
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
--
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
-----------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
68.58
40%
-103
- C1 -
3PY0
2
CDK2_HUMAN
A:
[17-304]
-------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
--
V
A
L
K
K
I
R----
T
----
E
G
V
P
----
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
--
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------
62
PsiBlast_CBE
68.42
40%
-107
- C1 -
3R7E
2
CDK2_HUMAN
A:
[17-304]
-------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
--
V
A
L
K
K
I
R----
T
----
E
G
V
P
----
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
--
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------
85
PsiBlast_CBE
68.28
40%
-106
- C1 -
3QTS
1
CDK2_HUMAN
A:
[17-304]
-------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
--
V
A
L
K
K
I
R------------
P
----
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
--
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
-----------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------
53
PsiBlast_CBE
68.25
40%
-100
- C1 -
3R8U
1
CDK2_HUMAN
A:
[17-304]
-------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
--
V
A
L
K
K
I
R----
T
----
E
G
V
P
----
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
--
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------
36
PsiBlast_CBE
68.22
40%
-104
- C1 -
3RM7
2
CDK2_HUMAN
A:
[17-304]
-------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
--
V
A
L
K
K
I
R----
T
----
E
G
V
P
----
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
--
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
68.16
40%
-104
- C1 -
3QQF
2
CDK2_HUMAN
A:
[17-304]
-------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
--
V
A
L
K
K
I
R----
T
----
E
G
V
P
----
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
--
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------
72
PsiBlast_CBE
68.15
40%
-104
- C1 -
3QZG
3
CDK2_HUMAN
A:
[17-304]
-------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
--
V
A
L
K
K
I
R----
T
----
E
G
V
P
----
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
--
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------
64
PsiBlast_CBE
68.12
40%
-106
- C1 -
3R71
2
CDK2_HUMAN
A:
[17-304]
-------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
--
V
A
L
K
K
I
R----
T
----
E
G
V
P
----
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
--
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------
59
PsiBlast_CBE
68.06
40%
-104
- C1 -
3R7V
2
CDK2_HUMAN
A:
[17-304]
-------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
--
V
A
L
K
K
I
R----
T
----
E
G
V
P
----
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
--
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------
52
PsiBlast_CBE
68.04
40%
-105
- C1 -
3R8V
1
CDK2_HUMAN
A:
[17-304]
-------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
--
V
A
L
K
K
I
R----
T
----
E
G
V
P
----
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
--
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
67.99
40%
-103
- C1 -
3QL8
2
CDK2_HUMAN
A:
[17-304]
-------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
--
V
A
L
K
K
I
R----
T
----
E
G
V
P
----
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
--
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------
54
PsiBlast_CBE
67.97
40%
-105
- C1 -
3R8P
1
CDK2_HUMAN
A:
[17-304]
-------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
--
V
A
L
K
K
I
R----
T
----
E
G
V
P
----
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
--
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
67.93
40%
-102
- C1 -
3PXF
7
CDK2_HUMAN
A:
[17-304]
-------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
--
V
A
L
K
K
I
R
L
D
T
E
T
----
E
G
V
P
----
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
--
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------
41
PsiBlast_CBE
67.91
40%
-104
- C1 -
3RK5
1
CDK2_HUMAN
A:
[17-304]
-------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
--
V
A
L
K
K
I
R----
T
----
E
G
V
P
----
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
--
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------
69
PsiBlast_CBE
67.90
40%
-103
- C1 -
3R1Q
2
CDK2_HUMAN
A:
[17-304]
-------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
--
V
A
L
K
K
I
R----
T
----
E
G
V
P
----
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
--
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------
94
PsiBlast_CBE
67.87
40%
-101
- C1 -
3QQG
2
CDK2_HUMAN
A:
[17-304]
-------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
--
V
A
L
K
K
I
R----
T
----
E
G
V
P
----
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
--
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------
87
PsiBlast_CBE
67.87
40%
-103
- C1 -
3QTQ
2
CDK2_HUMAN
A:
[17-304]
-------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
--
V
A
L
K
K
I
R----
T
----
E
G
V
P
----
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
--
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------
70
PsiBlast_CBE
67.85
40%
-104
- C1 -
3QZI
2
CDK2_HUMAN
A:
[17-304]
-------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
--
V
A
L
K
K
I
R----
T
----
E
G
V
P
----
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
--
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
67.83
40%
-101
- C1 -
3PXZ
3
CDK2_HUMAN
A:
[17-304]
-------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
--
V
A
L
K
K
I
R
L
D
T
E
T
----
E
G
V
P
----
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
--
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------
61
PsiBlast_CBE
67.82
40%
-102
- C1 -
3R7I
2
CDK2_HUMAN
A:
[17-304]
-------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
--
V
A
L
K
K
I
R------------
P
----
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
--
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
-----------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------
31
PsiBlast_CBE
67.78
40%
-107
- C1 -
3RPR
1
CDK2_HUMAN
A:
[17-304]
-------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
--
V
A
L
K
K
I
R------------
P
----
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
--
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
-----------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
67.77
40%
-100
- C1 -
3PXY
1
CDK2_HUMAN
A:
[17-304]
-------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
--
V
A
L
K
K
I
R----
T
----
E
G
V
P
----
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
--
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------
42
PsiBlast_CBE
67.73
40%
-106
- C1 -
3RJC
1
CDK2_HUMAN
A:
[17-304]
-------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
--
V
A
L
K
K
I
R----
T
----
E
G
V
P
----
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
--
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------
33
PsiBlast_CBE
67.66
40%
-104
- C1 -
3ROY
2
CDK2_HUMAN
A:
[17-304]
-------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
--
V
A
L
K
K
I
R----
T
----
E
G
V
P
----
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
--
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------
45
PsiBlast_CBE
67.56
40%
-104
- C1 -
3RAI
2
CDK2_HUMAN
A:
[17-304]
-------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
--
V
A
L
K
K
I
R----
T
----
E
G
V
P
----
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
--
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------
32
PsiBlast_CBE
67.55
40%
-102
- C1 -
3RPO
2
CDK2_HUMAN
A:
[17-304]
-------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
--
V
A
L
K
K
I
R----
T
----
E
G
V
P
----
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
--
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------
46
PsiBlast_CBE
67.53
40%
-104
- C1 -
3RAH
1
CDK2_HUMAN
A:
[17-304]
-------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
--
V
A
L
K
K
I
R------------
P
----
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
--
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
-----------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------
48
PsiBlast_CBE
67.45
40%
-105
- C1 -
3R9N
1
CDK2_HUMAN
A:
[17-304]
-------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
--
V
A
L
K
K
I
R------------
P
----
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
--
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
-----------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------
58
PsiBlast_CBE
67.35
40%
-104
- C1 -
3R7Y
2
CDK2_HUMAN
A:
[17-304]
-------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
--
V
A
L
K
K
I
R----
T
----
E
G
V
P
----
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
--
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------
56
PsiBlast_CBE
67.35
40%
-106
- C1 -
3R8L
1
CDK2_HUMAN
A:
[17-304]
-------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
--
V
A
L
K
K
I
R----
T
----
E
G
V
P
----
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
--
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------
23
PsiBlast_CBE
67.27
40%
-104
- C1 -
4EZ3
2
CDK2_HUMAN
A:
[17-304]
-------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
--
V
A
L
K
K
I
R----
T
----
E
G
V
P
----
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
--
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------
80
PsiBlast_CBE
67.25
40%
-99
- C1 -
3QU0
4
CDK2_HUMAN
A:
[17-304]
-------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
--
V
A
L
K
K
I
R----
T
----
E
G
V
P
----
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
--
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------
135
HHSearch
67.20
38%
-117
- C1 -
4NST
3
CDK12_HUMAN
A:
[19-313]
------------------------
G
I
I
G
E
G
T
Y
G
Q
V
Y
K
A
K
D
K
D
--
T
G
E
L
V
A
L
K
K
V
----
R
L
DNEK
E
G
F
P
----
I
T
A
I
R
E
I
K
I
L
R
Q
L
I
H
R
S
V
V
N
M
K
E
I
V
T
D
K
QD------
G
A
F
Y
L
V
F
E
Y
M
D
H
D
L
M
G
L
L
E
S
G
--------
L
V
H
F
S
E
D
H
I
K
S
F
M
K
Q
L
M
E
G
L
E
Y
C
H
K
K
N
F
L
H
R
D
I
K
C
S
N
I
L
L
N
N
----
S
G
Q
I
K
L
A
D
F
G
L
A
R
L
Y
N
S
E
E
S
--
R
P
Y
T
N
K
V
I
T
L
W
Y
R
P
P
E
L
L
L
G
E
E
R
Y
T
P
A
I
D
V
W
S
C
G
C
I
L
G
E
L
F
T
-
K
K
P
I
F
Q
A
N
L
---------
E
L
A
Q
L
E
L
I
S
R
L
C
G
S
P
C
P
A
V
W
P
D
V
I
K
L
P
Y
F
-
N
T
M
K
P
---
K
K
Q
--
Y
R
R
-
R
-
L
R
---
E
E
F
S
-
F
I
--
P
S
A
A
L
D
L
L
D
H
M
L
T
L
D
P
S
K
R
C
T
A
E
Q
T
L
Q
S
D
F
L
K
D
--
V
E
L
S
K
M
A
P
P
D
L
P
H
W
Q
D
C
H
E
L
W
S
K
K
---------------------------------------------------------------------------------------------------------------------------------------------
77
PsiBlast_CBE
67.14
40%
-102
- C1 -
3QX2
2
CDK2_HUMAN
A:
[17-304]
-------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
--
V
A
L
K
K
I
R----
T
----
E
G
V
P
----
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
--
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------
75
PsiBlast_CBE
67.02
40%
-102
- C1 -
3QXO
2
CDK2_HUMAN
A:
[17-304]
-------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
--
V
A
L
K
K
I
R----
T
----
E
G
V
P
----
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
--
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------
73
PsiBlast_CBE
66.80
40%
-102
- C1 -
3QZF
1
CDK2_HUMAN
A:
[17-304]
-------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
--
V
A
L
K
K
I
R----
T
----
E
G
V
P
----
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
--
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------
40
PsiBlast_CBE
66.78
40%
-100
- C1 -
3RK7
2
CDK2_HUMAN
A:
[17-304]
-------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
--
V
A
L
K
K
I
R----
T
----
E
G
V
P
----
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
--
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------
34
PsiBlast_CBE
66.65
40%
-103
- C1 -
3RNI
1
CDK2_HUMAN
A:
[17-304]
-------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
--
V
A
L
K
K
I
R----
T
----
E
G
V
P
----
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
--
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------
49
PsiBlast_CBE
66.64
40%
-105
- C1 -
3R9H
1
CDK2_HUMAN
A:
[17-304]
-------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
--
V
A
L
K
K
I
R----
T
----
E
G
V
P
----
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
--
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------
78
PsiBlast_CBE
66.59
40%
-101
- C1 -
3QWK
5
CDK2_HUMAN
A:
[17-304]
-------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
--
V
A
L
K
K
I
R----
T
----
E
G
V
P
----
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
--
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------
100
PsiBlast_CBE
66.41
40%
-103
- C1 -
4LYN
1
CDK2_HUMAN
A:
[9-296]
-------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
--
V
A
L
K
K
I
R
LDT
E
T
----
E
G
V
P
----
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
--
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
--------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------
89
PsiBlast_CBE
66.31
40%
-100
- C1 -
3QRT
3
CDK2_HUMAN
A:
[17-304]
-------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
--
V
A
L
K
K
I
R----
T
----
E
G
V
P
----
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
--
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------
39
PsiBlast_CBE
66.29
40%
-100
- C1 -
3RK9
1
CDK2_HUMAN
A:
[17-304]
-------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
--
V
A
L
K
K
I
R----
T
----
E
G
V
P
----
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
--
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------
26
PsiBlast_CBE
66.28
40%
-104
- C1 -
3S0O
1
CDK2_HUMAN
A:
[17-304]
-------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
--
V
A
L
K
K
I
R
L---
T
----
E
G
V
P
----
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
--
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
----
I
K
L
A
D
F
--
A
R
A
F
G
V
P
V
R
T
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------
82
PsiBlast_CBE
66.19
40%
-99
- C1 -
3QTX
1
CDK2_HUMAN
A:
[17-304]
-------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
--
V
A
L
K
K
I
R----
T
----
E
G
V
P
----
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
--
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------
88
PsiBlast_CBE
66.14
40%
-99
- C1 -
3QRU
2
CDK2_HUMAN
A:
[17-304]
-------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
--
V
A
L
K
K
I
R
L---
T
----
E
G
V
P
----
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
--
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------
81
PsiBlast_CBE
66.06
40%
-104
- C1 -
3QTZ
3
CDK2_HUMAN
A:
[17-304]
-------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
--
V
A
L
K
K
I
R----
T
----
E
G
V
P
----
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
--
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------
74
PsiBlast_CBE
66.03
40%
-103
- C1 -
3QXP
2
CDK2_HUMAN
A:
[17-304]
-------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
--
V
A
L
K
K
I
R----
T
----
E
G
V
P
----
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
--
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------
43
PsiBlast_CBE
66.01
40%
-105
- C1 -
3RAL
1
CDK2_HUMAN
A:
[17-304]
-------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
--
V
A
L
K
K
I
R------------
P
----
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
--
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
----------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------
76
PsiBlast_CBE
66.00
40%
-105
- C1 -
3QX4
3
CDK2_HUMAN
A:
[17-304]
-------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
--
V
A
L
K
K
I
R----
T
----
E
G
V
P
----
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
--
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------
50
PsiBlast_CBE
65.97
40%
-99
- C1 -
3R9D
1
CDK2_HUMAN
A:
[17-304]
-------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
--
V
A
L
K
K
I
R----
T
----
E
G
V
P
----
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
--
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------
90
PsiBlast_CBE
65.91
40%
-103
- C1 -
3QQL
1
CDK2_HUMAN
A:
[17-304]
-------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
--
V
A
L
K
K
I
R----
T
----
E
G
V
P
----
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
--
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------
99
PsiBlast_CBE
65.87
40%
-107
- C1 -
5A14
2
?
A:
[10-297]
-------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
--
V
A
L
K
K
I
R
L
D
--
T
----
E
G
V
P
----
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
--
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
-------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
30
PsiBlast_CBE
65.65
40%
-101
- C1 -
3RPV
2
CDK2_HUMAN
A:
[17-304]
-------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
--
V
A
L
K
K
I
R----
T
----
E
G
V
P
----
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
--
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
65.62
40%
-110
- C1 -
2IW8
1
CDK2_HUMAN
A:
[13-300]
-------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
--
V
A
L
K
K
I
R
L
D
T
E
T
----
E
G
V
P
----
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
--
T
E
----
N
K
L
Y
L
V
F
E
H
V
D
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
--------------------------------------------------------------------------------------------------------------------------------------------------------------
91
PsiBlast_CBE
65.59
40%
-100
- C1 -
3QQK
6
CDK2_HUMAN
A:
[17-304]
-------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
--
V
A
L
K
K
I
R----
T
----
E
G
V
P
----
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
--
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------
37
PsiBlast_CBE
65.54
40%
-100
- C1 -
3RM6
2
CDK2_HUMAN
A:
[17-304]
-------------------------
K
I
G
E
G
T
-
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
--
V
A
L
K
K
I
R----
T
----
E
G
V
P
----
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
--
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
65.52
40%
-104
- C1 -
4GCJ
5
CDK2_HUMAN
A:
[17-304]
-------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
--
V
A
L
K
K
I
R
L
DT
E
T
----
E
G
V
P
----
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
--
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------
35
PsiBlast_CBE
65.32
40%
-102
- C1 -
3RMF
1
CDK2_HUMAN
A:
[17-304]
-------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
--
V
A
L
K
K
I
R
L-----------
P
----
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
--
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
----------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------
47
PsiBlast_CBE
65.26
40%
-99
- C1 -
3R9O
1
CDK2_HUMAN
A:
[17-304]
-------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
--
V
A
L
K
K
I
R------------
P
----
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
--
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
-----------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------
44
PsiBlast_CBE
65.12
40%
-105
- C1 -
3RAK
1
CDK2_HUMAN
A:
[17-304]
-------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
--
V
A
L
K
K
I
R------------
P
----
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
--
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
----------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------
79
PsiBlast_CBE
65.10
40%
-100
- C1 -
3QWJ
2
CDK2_HUMAN
A:
[17-304]
-------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
--
V
A
L
K
K
I
R----
T
----
E
G
V
P
----
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
--
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------
95
PsiBlast_CBE
65.09
40%
-104
- C1 -
1OIT
1
CDK2_HUMAN
A:
[9-296]
-------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
-
G
E
V
--
V
A
L
K
K
I
-------------------
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
--
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
S
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
--------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------
29
PsiBlast_CBE
65.08
40%
-103
- C1 -
3RPY
1
CDK2_HUMAN
A:
[17-304]
-------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
--
V
A
L
K
K
I
R------------
P
----
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
--
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
----------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------
115
HHSearch
65.07
42%
-103
- C1 -
1UA2
1
CDK7_HUMAN
A:
[16-311]
------------------------
D
F
L
G
E
G
Q
F
A
T
V
Y
K
A
R
D
K
N
--
T
N
Q
I
V
A
I
K
K
I
-------------
N
----
R
T
A
L
R
E
I
K
L
L
Q
E
L
S
H
P
N
I
I
G
L
L
D
A
F
G
----
H
K
----
S
N
I
S
L
V
F
D
F
M
E
T
D
L
E
V
I
I
K
D
N
--------
S
L
V
L
T
P
S
H
I
K
A
Y
M
L
M
T
L
Q
G
L
E
Y
L
H
Q
H
W
I
L
H
R
D
L
K
P
N
N
L
L
L
D
E
----
N
G
V
L
K
L
A
D
F
G
L
A
K
S
F
G
S
P
N
R
A
---
Y
T
H
Q
V
V
T
R
W
Y
R
A
P
E
L
L
F
G
A
R
M
Y
G
V
G
V
D
M
W
A
V
G
C
I
L
A
E
L
L
L
-
R
V
P
F
L
P
G
D
S
---------
D
L
D
Q
L
T
R
I
F
E
T
L
G
T
P
T
E
E
Q
W
P
D
M
C
S
L
P
D
Y
-
V
T
F
----
K
--
S
--
F
P
G
-
I
P
L
H
H
I
F
S
----
A
A
--
G
D
D
L
L
D
L
I
Q
G
L
F
L
F
N
P
C
A
R
I
T
A
T
Q
A
L
K
M
K
Y
F
S
N
--
R
P
G
P
T
P
----
G
C
Q
L
P
R
P
N
---------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
64.83
40%
-98
- C1 -
3PXQ
4
CDK2_HUMAN
A:
[17-304]
-------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
--
V
A
L
K
K
I
R----
T
----
E
G
V
P
----
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
--
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
64.80
40%
-95
- C1 -
4EZ7
7
CDK2_HUMAN
A:
[17-304]
-------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
--
V
A
L
K
K
I
RLDT
E
T
----
E
G
V
P
----
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
--
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------
38
PsiBlast_CBE
64.65
40%
-100
- C1 -
3RKB
2
CDK2_HUMAN
A:
[17-304]
-------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
--
V
A
L
K
K
I
R----
T
----
E
G
V
P
----
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
--
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------
24
PsiBlast_CBE
64.60
40%
-97
- C1 -
3SQQ
2
CDK2_HUMAN
A:
[17-304]
-------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
--
V
A
L
K
K
I
R----
T
----
E
G
V
P
----
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
--
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
------
R
T
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------
55
PsiBlast_CBE
64.59
40%
-101
- C1 -
3R8M
1
CDK2_HUMAN
A:
[17-304]
-------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
--
V
A
L
K
K
I
R----
T
----
E
G
V
P
----
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
--
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
-----------
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------
86
PsiBlast_CBE
64.53
40%
-99
- C1 -
3QTR
1
CDK2_HUMAN
A:
[17-304]
-------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
--
V
A
L
K
K
I
R------------
P
----
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
--
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
-----------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------
96
PsiBlast_CBE
64.49
40%
-103
- C1 -
3EZV
1
CDK2_HUMAN
A:
[11-298]
-------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
--
V
A
L
K
K
I
R-----------
V
P
----
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
--
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
----
I
K
L
A
D
F
G
L
-----------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------
25
PsiBlast_CBE
64.37
40%
-103
- C1 -
3S1H
1
CDK2_HUMAN
A:
[17-304]
-------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
--
V
A
L
K
K
I
R------------
P
----
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
--
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
----------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
64.23
40%
-93
- C1 -
3PY1
4
CDK2_HUMAN
A:
[17-304]
-------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
--
V
A
L
K
K
I
R
L
D
T
E
T
----
E
G
V
P
----
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
--
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------
83
PsiBlast_CBE
64.18
40%
-95
- C1 -
3QTW
7
CDK2_HUMAN
A:
[17-304]
-------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
--
V
A
L
K
K
I
R----
T
----
E
G
V
P
----
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
--
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------
84
PsiBlast_CBE
63.89
40%
-100
- C1 -
3QTU
1
CDK2_HUMAN
A:
[17-304]
-------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
--
V
A
L
K
K
I
R----
T
----
E
G
V
P
----
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
--
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------
97
PsiBlast_CBE
63.36
40%
-101
- C1 -
3EZR
2
CDK2_HUMAN
A:
[11-298]
-------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
--
V
A
L
K
K
I
R-----------
V
P
----
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
--
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
----
I
K
L
A
D
F
---------------------
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------
28
PsiBlast_CBE
63.21
40%
-102
- C1 -
3RZB
1
CDK2_HUMAN
A:
[17-304]
-------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
--
V
A
L
K
K
I
R------------
P
----
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
--
H
--
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
-----------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------
131
HHSearch
63.09
42%
-114
- C1 -
4AU8
2
CDK5_HUMAN
A:
[12-293]
------------------------
E
K
I
G
E
G
T
Y
G
T
V
F
K
A
K
N
R
E
--
T
H
E
I
V
A
L
K
R
V
-------------
P
----
S
S
A
L
R
E
I
C
L
L
K
E
L
K
H
K
N
I
V
R
L
H
D
V
L
H
-----------
K
L
T
L
V
F
E
F
C
D
Q
D
L
K
K
Y
F
D
S
C
-----
N
---
G
D
L
D
P
E
I
V
K
S
F
L
F
Q
L
L
K
G
L
G
F
C
H
S
R
N
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
R
----
N
G
E
L
K
L
A
D
F
G
L
A
R
A
F
G
I
P
V
R
-----
S
A
E
V
V
T
L
W
Y
R
P
P
D
V
L
F
G
A
K
L
Y
S
T
S
I
D
M
W
S
A
G
C
I
F
A
E
L
A
N
A
G
R
P
L
F
P
G
N
D
V
---------
D
D
Q
L
K
R
I
F
R
L
L
G
T
P
T
E
E
Q
W
P
S
M
T
K
L
P
D
Y
-
K
P
Y
P
M
--------
Y
P
A
T
T
S
L
V
N
----
V
V
P
K
L
--
N
A
T
G
R
D
L
L
Q
N
L
L
K
C
N
P
V
Q
R
I
S
A
E
E
A
L
Q
H
P
Y
F
S
D
--
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
132
HHSearch
61.34
35%
-113
- C1 -
4BGQ
3
CDKL5_HUMAN
A:
[18-303]
------------------------
G
V
V
G
E
G
A
Y
G
V
V
L
K
C
R
H
K
E
--
T
H
E
I
V
A
I
K
K
F
----
K
-------
V
K
----
E
T
T
L
R
E
L
K
M
L
R
T
L
K
Q
E
N
I
V
E
L
K
E
A
F
R
R
----
R
----
G
K
L
Y
L
V
F
E
Y
V
E
K
N
M
L
E
L
L
E
E
M
--------
P
N
G
V
P
P
E
K
V
K
S
Y
I
Y
Q
L
I
K
A
I
H
W
C
H
K
N
D
I
V
H
R
D
I
K
P
E
N
L
L
I
S
H
----
N
D
V
L
K
L
C
D
F
G
F
A
R
N
L
S
E
-------------
T
R
W
Y
R
S
P
E
L
L
L
G
-
A
P
Y
G
K
S
V
D
M
W
S
V
G
C
I
L
G
E
L
S
D
-
G
Q
P
L
F
P
G
E
S
E
---------
I
D
Q
L
F
T
I
Q
K
V
L
G
P
L
P
S
E
Q
M
K
L
F
Y
S
N
P
R
F
-
H
G
L
R
--
F
P
A
V
N
--
H
P
Q
-
S
L
E
R
R
Y
L
----
G
I
L
--
N
S
V
L
L
D
L
M
K
N
L
L
K
L
D
P
A
D
R
Y
L
T
E
Q
C
L
N
H
P
T
F
Q
T
--
Q
R
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------
127
HHSearch
52.82
35%
-116
- C1 -
2FST
3
MK14_HUMAN
X:
[35-323]
------------------------
S
P
V
G
----
G
S
V
C
A
A
F
D
T
--
K
T
G
L
R
V
A
V
K
K
L
----
S
R
----
P
F
Q
S
IIHA
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
P
A
--
R
S
LEEF
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
---------------
Q
K
L
T
D
D
H
V
Q
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
E
----
D
C
E
L
K
I
L
D
---------------------
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
-
G
R
T
L
F
P
G
T
D
---------
H
I
D
Q
L
K
L
I
L
R
L
V
G
T
P
G
A
E
L
L
K
K
I
S
S
------
E
S
A
R
N
Y
I
Q
S
L
TQ
M
P
K
-
M
N
F
A
N
V
F
----
I
G
A
--
N
P
L
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
--
Y
H
D
P
D
D
E
P
V
A
D
P
Y
D
Q
S
L
E
S
R
D
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
V
P
P
P
---------------------------------------------------------------------------------------------------------------------------
130
HHSearch
24.99
41%
2
- C1 -
4EK4
1
CDK2_HUMAN
A:
[11-294]
------------------------
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
--
T
G
E
V
V
A
L
K
K
I
-------------
P
----
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
----
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
A
-------
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
----
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
---
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
---------
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
-
K
P
S
F
P
K
W
A
R
Q
D
--
F
S
------
K
V
----
V
P
P
L
--
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
--
V
T
K
P
V
P
H
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------