@TOME V2.3
(Nov 2016)
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : CDK4_HUMAN: (2015-10-05 )
MATSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVVTLWYRAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLHKDEGNPE
Atome Classification :
(74 SA)
.........10........20........30........40........50........60........70........80..-..-....90........100....--...110.......120.......130.......140.......150........160......-----.-170.......180.......-190........200.......-----------210......-------.220.......230.......240.-..-----.---...250-..-...-..260.-.------------.....270.......280.......290.......300.
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MATSRYE
P
V
A
E
IGVGAYG
T
V
Y
KARDPHSG
H
F
V
A
L
K
S
V
RVPNGGGGGGGL
P
I
S
T
V
R
E
V
A
L
L
R
R
L
E
A
FEHP
N
V
V
R
L
M
D
V
CATSRT-D
R
-
E
I
K
V
T
L
V
F
E
HV
D
Q
D
L
R
T
Y
L
DK--APPPGL
P
A
E
T
I
K
D
L
M
R
Q
F
L
R
G
L
D
F
L
H
A
N
C
I
V
HRDLKPE
N
I
L
V
TS-G
G
T
V
K
L
A
D
F
G
L
A
R
I
Y
S
Y
Q
-----
M
-
A
L
T
P
V
V
V
T
L
W
YR
A
P
E
V
L
L
Q
S-T-YAT
P
V
D
M
W
S
V
G
C
I
F
A
E
M
F
R-----------RKPLFCGNS-------
E
A
D
Q
L
G
K
I
F
D
LIGLPPEDDWPRDVS-LP-----R---GAFPPR-GP-R
P
V
-
Q
S
V
V
P
E
-
M
------------
E
E
S
G
A
Q
L
L
L
E
M
LTFNP
H
K
R
I
S
A
F
R
A
L
Q
H
S
Y
LHKDEGNPE
78
PsiBlast_CBE
80.61
45%
-130
- C1 -
2W06
2
CDK2_HUMAN
A:
[4-287]
-----
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
----------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
T
-------
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
--
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
--------------
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
-
M
P
DY---
K
---
P
S
F
P
K
W
-
A
R
-
Q
D
F
-
S
K
V
V
P
P
-
L
------------
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
91
PsiBlast_CBE
80.40
45%
-131
- C1 -
2VTI
1
CDK2_HUMAN
A:
[4-287]
-----
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
-----------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
T
-------
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
--
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
---------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
-
M
P
DY---
K
---
P
S
F
P
K
W
-
A
R
-
Q
D
F
-
S
K
V
V
P
P
-
L
------------
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
43
PsiBlast_CBE
80.14
45%
-132
- C1 -
4D1X
1
CDK2_HUMAN
A:
[4-287]
-----
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
--------------
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
T
-------
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
--
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
----------------
T
L
W
Y
R
A
P
E
I
L
L
G
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
-
M
P
DY---
K
---
P
S
F
P
K
W
-
A
R
-
Q
D
F
-
S
K
V
V
P
P
-
L
------------
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
92
PsiBlast_CBE
79.97
45%
-131
- C1 -
2VTH
2
CDK2_HUMAN
A:
[4-287]
-----
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
------------
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
T
-------
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
--
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
----------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
-
M
P
DY---
K
---
P
S
F
P
K
W
-
A
R
-
Q
D
F
-
S
K
V
V
P
P
-
L
------------
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
70
PsiBlast_CBE
79.76
45%
-129
- C1 -
2XNB
1
CDK2_HUMAN
A:
[4-287]
-----
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
--
T
E
G
---
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
T
-------
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
--
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
-----
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
-
M
P
DY---
K
---
P
S
F
P
K
W
-
A
R
-
Q
D
F
-
S
K
V
V
P
P
-
L
------------
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
66
PsiBlast_CBE
79.76
45%
-129
- C1 -
3EOC
1
CDK2_HUMAN
A:
[4-287]
-----
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
---
T
E
G
---
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
T
-------
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
--
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
-----
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
-
M
P
DY---
K
---
P
S
F
P
K
W
-
A
R
-
Q
D
F
-
S
K
V
V
P
P
-
L
------------
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
56
PsiBlast_CBE
79.72
45%
-131
- C1 -
3NS9
1
CDK2_HUMAN
A:
[4-287]
-----
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
-------
G
---
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
T
-------
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
--
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
-----
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
-
M
P
DY---
K
---
P
S
F
P
K
W
-
A
R
-
Q
D
F
-
S
K
V
V
P
P
-
L
------------
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
86
PsiBlast_CBE
79.71
45%
-128
- C1 -
2VTO
1
CDK2_HUMAN
A:
[4-287]
-----
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
----------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
T
-------
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
--
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
-------------
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
-
M
P
DY---
K
---
P
S
F
P
K
W
-
A
R
-
Q
D
F
-
S
K
V
V
P
P
-
L
------------
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
71
PsiBlast_CBE
79.69
45%
-125
- C1 -
2XMY
1
CDK2_HUMAN
A:
[4-287]
-----
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
---
G
---
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
T
-------
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
--
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
-----
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
-
M
P
DY---
K
---
P
S
F
P
K
W
-
A
R
-
Q
D
F
-
S
K
V
V
P
P
-
L
------------
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
94
PsiBlast_CBE
79.67
45%
-130
- C1 -
2V0D
1
CDK2_HUMAN
A:
[4-287]
-----
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
---------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
T
-------
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
--
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
-----
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
-
M
P
DY---
K
---
P
S
F
P
K
W
-
A
R
-
Q
D
F
-
S
K
V
V
P
P
-
L
------------
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
55
PsiBlast_CBE
79.64
45%
-130
- C1 -
3S2P
1
CDK2_HUMAN
A:
[4-287]
-----
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
-----------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
T
-------
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
--
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
----------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
-
M
P
DY---
K
---
P
S
F
P
K
W
-
A
R
-
Q
D
F
-
S
K
V
V
P
P
-
L
------------
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
49
PsiBlast_CBE
79.51
45%
-130
- C1 -
3ULI
1
CDK2_HUMAN
A:
[4-287]
-----
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
--------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
T
-------
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
--
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
------------
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
-
M
P
DY---
K
---
P
S
F
P
K
W
-
A
R
-
Q
D
F
-
S
K
V
V
P
P
-
L
------------
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
97
PsiBlast_CBE
79.38
45%
-127
- C1 -
2UUE
1
CDK2_HUMAN
C:
[4-287]
-----
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
---
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
T
-------
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
--
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
-----
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
-
M
P
DY---
K
---
P
S
F
P
K
W
-
A
R
-
Q
D
F
-
S
K
V
V
P
P
-
L
------------
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
85
PsiBlast_CBE
79.38
45%
-130
- C1 -
2VTP
1
CDK2_HUMAN
A:
[4-287]
-----
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
-----------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
T
-------
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
--
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
--------------
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
-
M
P
DY---
K
---
P
S
F
P
K
W
-
A
R
-
Q
D
F
-
S
K
V
V
P
P
-
L
------------
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
68
PsiBlast_CBE
79.33
45%
-130
- C1 -
3EJ1
1
CDK2_HUMAN
A:
[4-287]
-----
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
---
T
E
G
---
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
T
-------
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
--
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
-----
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
-
M
P
DY---
K
---
P
S
F
P
K
W
-
A
R
-
Q
D
F
-
S
K
V
V
P
P
-
L
------------
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
95
PsiBlast_CBE
79.28
45%
-129
- C1 -
2UZO
1
CDK2_HUMAN
A:
[4-287]
-----
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
---------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
T
-------
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
--
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
-----
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
-
M
P
DY---
K
---
P
S
F
P
K
W
-
A
R
-
Q
D
F
-
S
K
V
V
P
P
-
L
------------
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
51
PsiBlast_CBE
79.28
45%
-132
- C1 -
3TIY
12
CDK2_HUMAN
A:
[4-287]
-----
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
---
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
T
-------
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
--
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
-----
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
-
M
P
DY---
K
---
P
S
F
P
K
W
-
A
R
-
Q
D
F
-
S
K
V
V
P
P
-
L
------------
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
72
PsiBlast_CBE
79.25
45%
-126
- C1 -
2X1N
1
CDK2_HUMAN
C:
[4-287]
-----
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
---
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
T
-------
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
--
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
-----
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
-
M
P
DY---
K
---
P
S
F
P
K
W
-
A
R
-
Q
D
F
-
S
K
V
V
P
P
-
L
------------
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
63
PsiBlast_CBE
79.25
45%
-128
- C1 -
3F5X
2
CDK2_HUMAN
C:
[4-287]
-----
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
---
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
T
-------
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
--
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
-----
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
-
M
P
DY---
K
---
P
S
F
P
K
W
-
A
R
-
Q
D
F
-
S
K
V
V
P
P
-
L
------------
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
59
PsiBlast_CBE
79.25
45%
-128
- C1 -
3LFN
1
CDK2_HUMAN
A:
[4-287]
-----
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
---
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
T
-------
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
--
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
--------------
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
-
M
P
DY---
K
---
P
S
F
P
K
W
-
A
R
-
Q
D
F
-
S
K
V
V
P
P
-
L
------------
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
47
PsiBlast_CBE
79.25
45%
-126
- C1 -
3UNK
1
CDK2_HUMAN
A:
[4-287]
-----
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
---
E
T
E
G
---
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
T
-------
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
--
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
-----
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
-
M
P
DY---
K
---
P
S
F
P
K
W
-
A
R
-
Q
D
F
-
S
K
V
V
P
P
-
L
------------
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
48
PsiBlast_CBE
79.18
45%
-132
- C1 -
3UNJ
1
CDK2_HUMAN
A:
[4-287]
-----
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
---
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
T
-------
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
--
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
-----
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
-
M
P
DY---
K
---
P
S
F
P
K
W
-
A
R
-
Q
D
F
-
S
K
V
V
P
P
-
L
------------
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
46
PsiBlast_CBE
79.08
45%
-129
- C1 -
3WBL
1
CDK2_HUMAN
A:
[4-287]
-----
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
-
T
G
E
V
V
A
L
K
K
I
R
L
-----
G
---
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
T
-------
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
--
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
--------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
-
M
P
DY---
K
---
P
S
F
P
K
W
-
A
R
-
Q
D
F
-
S
K
V
V
P
P
-
L
------------
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
99
PsiBlast_CBE
79.02
45%
-132
- C1 -
2R64
1
CDK2_HUMAN
A:
[4-287]
-----
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
-----------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
T
-------
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
--
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
----------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
-
M
P
DY---
K
---
P
S
F
P
K
W
-
A
R
-
Q
D
F
-
S
K
V
V
P
P
-
L
------------
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
50
PsiBlast_CBE
78.99
45%
-129
- C1 -
3TIZ
9
CDK2_HUMAN
A:
[4-287]
-----
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
---
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
T
-------
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
--
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
-----
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
-
M
P
DY---
K
---
P
S
F
P
K
W
-
A
R
-
Q
D
F
-
S
K
V
V
P
P
-
L
------------
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
96
PsiBlast_CBE
78.88
45%
-128
- C1 -
2UZN
1
CDK2_HUMAN
A:
[4-287]
-----
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
------------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
T
-------
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
--
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
---------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
-
M
P
DY---
K
---
P
S
F
P
K
W
-
A
R
-
Q
D
F
-
S
K
V
V
P
P
-
L
------------
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
64
PsiBlast_CBE
78.88
45%
-130
- C1 -
3F5X
2
CDK2_HUMAN
A:
[4-287]
-----
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
---
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
T
-------
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
--
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
-----
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
-
M
P
DY---
K
---
P
S
F
P
K
W
-
A
R
-
Q
D
F
-
S
K
V
V
P
P
-
L
------------
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
-
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
57
PsiBlast_CBE
78.76
45%
-130
- C1 -
3LFS
1
CDK2_HUMAN
A:
[4-287]
-----
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
-----------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
T
-------
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
--
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
-----
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
-
M
P
DY---
K
---
P
S
F
P
K
W
-
A
R
-
Q
D
F
-
S
K
V
V
P
P
-
L
------------
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
82
PsiBlast_CBE
78.65
45%
-129
- C1 -
2VTS
1
CDK2_HUMAN
A:
[4-287]
-----
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
-----------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
T
-------
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
--
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
-------------
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
-
M
P
DY---
K
---
P
S
F
P
K
W
-
A
R
-
Q
D
F
-
S
K
V
V
P
P
-
L
------------
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
76
PsiBlast_CBE
78.62
45%
-125
- C1 -
2W1H
1
CDK2_HUMAN
A:
[4-287]
-----
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
---
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
T
-------
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
--
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
----------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
-
M
P
DY---
K
---
P
S
F
P
K
W
-
A
R
-
Q
D
F
-
S
K
V
V
P
P
-
L
------------
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
98
PsiBlast_CBE
78.61
45%
-128
- C1 -
2UUE
1
CDK2_HUMAN
A:
[4-287]
-----
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
---
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
T
-------
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
--
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
-----
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
-
M
P
DY---
K
---
P
S
F
P
K
W
-
A
R
-
Q
D
F
-
S
K
V
V
P
P
-
L
------------
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
67
PsiBlast_CBE
78.56
45%
-129
- C1 -
3EJ1
1
CDK2_HUMAN
C:
[4-287]
-----
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
---
T
E
G
---
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
T
-------
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
--
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
-----
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
-
M
P
DY---
K
---
P
S
F
P
K
W
-
A
R
-
Q
D
F
-
S
K
V
V
P
P
-
L
------------
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
58
PsiBlast_CBE
78.50
45%
-130
- C1 -
3LFQ
1
CDK2_HUMAN
A:
[4-287]
-----
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
------------
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
T
-------
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
--
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
-----
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
-
M
P
DY---
K
---
P
S
F
P
K
W
-
A
R
-
Q
D
F
-
S
K
V
V
P
P
-
L
------------
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
65
PsiBlast_CBE
78.32
45%
-130
- C1 -
3EOC
1
CDK2_HUMAN
C:
[4-287]
-----
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
---
T
E
G
---
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
T
-------
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
--
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
-----
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
-
M
P
DY---
K
---
P
S
F
P
K
W
-
A
R
-
Q
D
F
-
S
K
V
V
P
P
-
L
------------
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
62
PsiBlast_CBE
78.17
45%
-127
- C1 -
3FZ1
1
CDK2_HUMAN
A:
[4-287]
-----
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
----------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
T
-------
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
--
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
------------
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
-
M
P
DY---
K
---
P
S
F
P
K
W
-
A
R
-
Q
D
F
-
S
K
V
V
P
P
-
L
------------
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
75
PsiBlast_CBE
78.16
45%
-127
- C1 -
2WEV
1
CDK2_HUMAN
A:
[4-287]
-----
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
---
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
T
-------
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
--
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
-----
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
-
M
P
DY---
K
---
P
S
F
P
K
W
-
A
R
-
Q
D
F
-
S
K
V
V
P
P
-
L
------------
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
83
PsiBlast_CBE
78.13
45%
-126
- C1 -
2VTR
1
CDK2_HUMAN
A:
[4-287]
-----
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
-----------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
T
-------
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
--
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
-----
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
-
M
P
DY---
K
---
P
S
F
P
K
W
-
A
R
-
Q
D
F
-
S
K
V
V
P
P
-
L
------------
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
44
PsiBlast_CBE
78.05
45%
-127
- C1 -
4BZD
1
CDK2_HUMAN
A:
[5-288]
-----
F
Q
K
V
E
K
I
G
E
G
-
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
---------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
T
-------
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
--
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
-------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
-
M
P
DY---
K
---
P
S
F
P
K
W
-
A
R
-
Q
D
F
-
S
K
V
V
P
P
-
L
------------
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
93
PsiBlast_CBE
77.91
45%
-126
- C1 -
2VTA
3
CDK2_HUMAN
A:
[4-287]
-----
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
------------
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
T
-------
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
--
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
----------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
-
M
P
DY---
K
---
P
S
F
P
K
W
-
A
R
-
Q
D
F
-
S
K
V
V
P
P
-
L
------------
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
87
PsiBlast_CBE
77.87
45%
-122
- C1 -
2VTN
1
CDK2_HUMAN
A:
[4-287]
-----
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
-----------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
T
-------
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
--
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
---------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
-
M
P
DY---
K
---
P
S
F
P
K
W
-
A
R
-
Q
D
F
-
S
K
V
V
P
P
-
L
------------
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
69
PsiBlast_CBE
77.87
45%
-131
- C1 -
3EID
1
CDK2_HUMAN
A:
[4-287]
-----
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
---
T
E
G
---
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
T
-------
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
--
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
-----
V
R
T
Y
T
--
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
-
M
P
DY---
K
---
P
S
F
P
K
W
-
A
R
-
Q
D
F
-
S
K
V
V
P
P
-
L
------------
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
45
PsiBlast_CBE
77.69
45%
-127
- C1 -
4BGH
1
CDK2_HUMAN
A:
[4-287]
-----
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
------------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
T
-------
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
--
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
-------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
-
M
P
DY---
K
---
P
S
F
P
K
W
-
A
R
-
Q
D
F
-
S
K
V
V
P
P
-
L
------------
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
88
PsiBlast_CBE
77.66
45%
-129
- C1 -
2VTM
1
CDK2_HUMAN
A:
[4-287]
-----
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
-----------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
T
-------
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
--
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
-----
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
-
M
P
DY---
K
---
P
S
F
P
K
W
-
A
R
-
Q
D
F
-
S
K
V
V
P
P
-
L
------------
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
73
PsiBlast_CBE
77.45
45%
-127
- C1 -
2X1N
1
CDK2_HUMAN
A:
[4-287]
-----
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
---
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
T
-------
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
--
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
-----
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
-
M
P
DY---
K
---
P
S
F
P
K
W
-
A
R
-
Q
D
F
-
S
K
V
V
P
P
-
L
------------
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
74
PsiBlast_CBE
77.32
45%
-126
- C1 -
2WEV
1
CDK2_HUMAN
C:
[4-287]
-----
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
---
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
T
-------
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
--
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
-----
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
-
M
P
DY---
K
---
P
S
F
P
K
W
-
A
R
-
Q
D
F
-
S
K
V
V
P
P
-
L
------------
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
79
PsiBlast_CBE
76.90
45%
-127
- C1 -
2W05
1
CDK2_HUMAN
A:
[4-287]
-----
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
------------
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
T
-------
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
--
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
------------------
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
-
M
P
DY---
K
---
P
S
F
P
K
W
-
A
R
-
Q
D
F
-
S
K
V
V
P
P
-
L
------------
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
89
PsiBlast_CBE
76.88
45%
-125
- C1 -
2VTL
1
CDK2_HUMAN
A:
[4-287]
-----
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
-----------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
T
-------
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
--
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
-----
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
-
M
P
DY---
K
---
P
S
F
P
K
W
-
A
R
-
Q
D
F
-
S
K
V
V
P
P
-
L
------------
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
90
PsiBlast_CBE
76.70
45%
-124
- C1 -
2VTJ
2
CDK2_HUMAN
A:
[4-287]
-----
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
------------
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
T
-------
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
--
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
-
M
P
DY---
K
---
P
S
F
P
K
W
-
A
R
-
Q
D
F
-
S
K
V
V
P
P
-
L
------------
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
84
PsiBlast_CBE
75.99
45%
-128
- C1 -
2VTQ
1
CDK2_HUMAN
A:
[4-287]
-----
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
------------
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
T
-------
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
--
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
--------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
-
M
P
DY---
K
---
P
S
F
P
K
W
-
A
R
-
Q
D
F
-
S
K
V
V
P
P
-
L
------------
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
124
HHSearch
75.29
46%
-120
- C1 -
4AU8
2
CDK5_HUMAN
A:
[4-293]
-
G
S
Q
K
Y
E
K
L
E
K
I
G
E
G
T
Y
G
T
V
F
K
A
K
N
R
E
T
H
E
I
V
A
L
K
R
V
------------
P
S
S
A
L
R
E
I
C
L
L
K
E
L
K
---
H
K
N
I
V
R
L
H
D
V
L
H
----------
K
L
T
L
V
F
E
F
C
D
Q
D
L
K
K
Y
F
D
S
--
C
N
-
G
D
L
D
P
E
I
V
K
S
F
L
F
Q
L
L
K
G
L
G
F
C
H
S
R
N
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
R
-
N
G
E
L
K
L
A
D
F
G
L
A
R
A
F
G
I
P
-----
V
R--
S
A
E
V
V
T
L
W
Y
R
P
P
D
V
L
F
G
A
-
K
L
Y
S
T
S
I
D
M
W
S
A
G
C
I
F
A
E
L
A
N
A
----------
G
R
P
L
F
P
G
N
D
-------
V
D
D
Q
L
K
R
I
F
R
L
L
G
T
P
T
E
E
Q
W
P
S
M
T
K
-
L
P
-----
D
Y
--
K
P
Y
P
M
Y
-
P
A
T
T
S
L
-
V
N
V
V
P
K
-
L
------------
N
A
T
G
R
D
L
L
Q
N
L
L
K
C
N
P
V
Q
R
I
S
A
E
E
A
L
Q
H
P
Y
F
S
D
F
-----
81
PsiBlast_CBE
75.13
45%
-126
- C1 -
2VU3
1
CDK2_HUMAN
A:
[4-287]
-----
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
------------
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
T
-------
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
--
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
----
F
G
V
P
-----
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
-
M
P
DY---
K
---
P
S
F
P
K
W
-
A
R
-
Q
D
F
-
S
K
V
V
P
P
-
L
------------
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
127
HHSearch
73.63
35%
-114
- C1 -
2B9H
1
FUS3_YEAST
A:
[10-312]
--
S
S
D
F
Q
L
K
S
L
L
G
E
G
A
Y
G
V
V
C
S
A
T
H
K
P
T
G
E
I
V
A
I
K
K
I
E
P
F
D
-
K
P
L
---
F
A
L
R
T
L
R
E
I
K
I
L
K
H
F
K
---
H
E
N
I
I
T
I
F
N
I
Q
R
P
D
S
F
-
E
N
-
F
N
E
V
Y
I
I
Q
E
L
M
Q
T
D
L
H
R
V
I
S
T
--
Q
---
M
L
S
D
D
H
I
Q
Y
F
I
Y
Q
T
L
R
A
V
K
V
L
H
G
S
N
V
I
H
R
D
L
K
P
S
N
L
L
I
N
S
-
N
C
D
L
K
V
C
D
F
G
L
A
R
I
I
D
-----------
V
E
F
V
A
T
R
W
Y
R
A
P
E
V
M
L
T
S
-
A
K
Y
S
R
A
M
D
V
W
S
C
G
C
I
L
A
E
L
F
L
-----------
R
R
P
I
F
P
G
R
D
-------
Y
R
H
Q
L
L
L
I
F
G
I
I
G
T
P
H
S
D
N
D
L
R
C
I
E
-
S
P
R
A
R
E
Y
I
---
K
S
L
P
M
Y
-
P
A
-
A
P
L
-
E
K
M
F
P
R
-
V
------------
N
P
K
G
I
D
L
L
Q
R
M
L
V
F
D
P
A
K
R
I
T
A
K
E
A
L
E
H
P
Y
L
Q
T
Y
H
D
P
N
D
116
HHSearch
72.67
39%
-102
- C1 -
3N9X
2
?
A:
[26-369]
---
D
N
Y
I
I
K
H
L
I
G
R
G
S
Y
G
Y
V
Y
L
A
Y
D
K
N
T
E
K
N
V
A
I
K
K
V
N
R
M
F
E
D
L
I
---
D
C
K
R
I
L
R
E
I
T
I
L
N
R
L
K
---
S
D
Y
I
I
R
L
Y
D
L
I
I
P
D
D
L
-
L
K
-
F
D
E
L
Y
I
V
L
E
I
A
D
S
D
L
K
K
L
F
K
T
--
P
--
I
F
L
T
E
E
H
I
K
T
I
L
Y
N
L
L
L
G
E
N
F
I
H
E
S
G
I
I
H
R
D
L
K
P
A
N
C
L
L
N
Q
-
D
C
S
V
K
V
C
D
F
G
L
A
R
T
I
--------------
H
V
V
T
R
W
Y
R
A
P
E
L
I
L
L
Q
-
E
N
Y
T
K
S
I
D
I
W
S
T
G
C
I
F
A
E
L
L
N
MLQSHINDPTN
R
F
P
L
F
P
G
S
S
CFPH
E
K
S
N
R
D
Q
L
N
I
I
F
N
I
I
G
T
P
T
E
D
D
L
K
N
I
N
K
-
P
E
V
I
K
Y
-
I
---
K
L
F
P
H
R
-
K
P
-
I
N
L
-
K
Q
K
Y
P
S
-
I
------------
S
D
D
G
I
N
L
L
E
S
M
L
K
F
N
P
N
K
R
I
T
I
D
Q
A
L
D
H
P
Y
L
K
D
V
R
K
K
K
L
130
HHSearch
69.85
35%
-109
- C1 -
4BGQ
3
CDKL5_HUMAN
A:
[11-301]
--
M
N
K
F
E
I
L
G
V
V
G
E
G
A
Y
G
V
V
L
K
C
R
H
K
E
T
H
E
I
V
A
I
K
K
F
K
----------
V
K
E
T
T
L
R
E
L
K
M
L
R
T
L
K
---
Q
E
N
I
V
E
L
K
E
A
F
R
R
-------
R
G
K
L
Y
L
V
F
E
Y
V
E
K
N
M
L
E
L
L
E
E
--
M
P
-
N
G
V
P
P
E
K
V
K
S
Y
I
Y
Q
L
I
K
A
I
H
W
C
H
K
N
D
I
V
H
R
D
I
K
P
E
N
L
L
I
S
H
-
N
D
V
L
K
L
C
D
F
G
F
A
R
N
L
S
E
---------------
T
R
W
Y
R
S
P
E
L
L
L
G
A
-
P
-
Y
G
K
S
V
D
M
W
S
V
G
C
I
L
G
E
L
S
D
-----------
G
Q
P
L
F
P
G
E
S
-------
E
I
D
Q
L
F
T
I
Q
K
V
L
G
P
L
P
S
E
Q
M
K
L
F
Y
S
-
N
P
-----
R
FHG
L
R
F
P
A
V
N
H
P
-
Q
S
L
E
R
R
Y
L
G
I
-
L
------------
N
S
V
L
L
D
L
M
K
N
L
L
K
L
D
P
A
D
R
Y
L
T
E
Q
C
L
N
H
P
T
F
Q
T
Q
R
L
---
117
HHSearch
69.67
30%
-123
- C1 -
3EB0
3
?
A:
[6-327]
--
S
K
K
Y
S
L
G
K
T
L
G
T
G
-
F
G
I
V
C
E
V
F
D
I
E
S
G
K
R
F
A
L
K
K
V
L
Q
D
P
R
---------
Y
K
N
R
E
L
D
I
M
K
V
L
---
D
H
V
N
I
I
K
L
V
D
Y
F
Y
T
T
------
N
K
Y
L
N
V
I
M
E
Y
V
P
D
T
L
H
K
V
L
K
S
F
I
R
S
G
R
S
I
P
M
N
L
I
S
I
Y
I
Y
Q
L
F
R
A
V
G
F
I
H
S
L
G
I
C
H
R
D
I
K
P
Q
N
L
L
V
N
S
K
D
N
T
L
K
L
C
D
F
G
S
A
K
K
L
I
P
S
-----
E
-
P
S
V
A
Y
I
C
S
R
F
Y
R
A
P
E
L
M
L
G
A
-
T
E
Y
T
P
S
I
D
L
W
S
I
G
C
V
F
G
E
L
I
L
-----------
G
K
P
L
F
S
G
E
T
-------
S
I
D
Q
L
V
R
I
I
Q
I
M
G
T
P
T
K
E
Q
M
I
R
M
N
P
H
Y
----------
V
R
F
P
T
L
-
K
A
-
K
D
W
-
R
K
I
L
P
E
G
T
------------
P
S
L
A
I
D
L
L
E
Q
I
L
R
Y
E
P
D
L
R
I
N
P
Y
E
A
M
A
H
P
F
F
D
H
L
R
N
S
I
P
115
HHSearch
67.03
38%
-108
- C1 -
1UA2
1
CDK7_HUMAN
A:
[13-299]
------
E
K
L
D
F
L
G
E
G
Q
F
A
T
V
Y
K
A
R
D
K
N
T
N
Q
I
V
A
I
K
K
I
------------
N
R
T
A
L
R
E
I
K
L
L
Q
E
L
S
---
H
P
N
I
I
G
L
L
D
A
F
G
H
-------
K
S
N
I
S
L
V
F
D
F
M
E
T
D
L
E
V
I
I
K
D
--
N
-
S
L
V
L
T
P
S
H
I
K
A
Y
M
L
M
T
L
Q
G
L
E
Y
L
H
Q
H
W
I
L
H
R
D
L
K
P
N
N
L
L
L
D
E
-
N
G
V
L
K
L
A
D
F
G
L
A
K
S
F
G
S
P
-----
N
R
A
Y
T
H
Q
V
V
T
R
W
Y
R
A
P
E
L
L
F
G
A
-
R
M
Y
G
V
G
V
D
M
W
A
V
G
C
I
L
A
E
L
L
L
-----------
R
V
P
F
L
P
G
D
S
-------
D
L
D
Q
L
T
R
I
F
E
T
L
G
T
P
T
E
E
Q
W
P
D
M
C
S
-
L
P
D
----
Y
---
V
T
F
K
S
F
-
P
G
-
I
P
L
-
H
H
I
F
S
A
-
A
------------
G
D
D
L
L
D
L
I
Q
G
L
F
L
F
N
P
C
A
R
I
T
A
T
Q
A
L
K
M
K
Y
F
S
N
R
P
G
P
T
P
122
HHSearch
65.82
37%
-115
- C1 -
1CM8
1
MK12_HUMAN
A:
[25-314]
---
A
V
Y
R
D
L
Q
P
V
------
A
V
C
S
A
V
D
G
R
T
G
A
K
V
A
I
K
K
L
Y
R
P
F
Q
S
E
L
---
F
A
K
R
A
Y
R
E
L
R
L
L
K
H
M
---
R
H
E
N
V
I
G
L
L
D
V
F
T
P
D
E
T
L
D
D
-
F
T
D
F
Y
L
V
M
P
F
M
G
T
D
L
G
K
L
M
K
H
--
E
---
K
L
G
E
D
R
I
Q
F
L
V
Y
Q
M
L
K
G
L
R
Y
I
H
A
A
G
I
I
H
R
D
L
K
P
G
N
L
A
V
N
E
-
D
C
E
L
K
I
L
D
F
G
L
A
R
Q
A
D
S
E
-----
M
---
T
G
Y
V
V
T
R
W
Y
R
A
P
E
V
I
L
N
W
M
R
-
Y
T
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
M
I
T
-----------
G
K
T
L
F
K
G
S
D
-------
H
L
D
Q
L
K
E
I
M
K
V
T
G
T
P
P
A
E
F
V
Q
R
L
Q
S
-
D
E
A
K
N
Y
-
M
---
K
G
L
P
E
L
-
E
K
-
K
D
F
-
A
S
I
L
T
N
-
A
------------
S
P
L
A
V
N
L
L
E
K
M
L
V
L
D
A
E
Q
R
V
T
A
G
E
A
L
A
H
P
Y
F
E
S
L
H
Q
V
Q
K
119
HHSearch
65.76
35%
-110
- C1 -
4IC7
1
MK07_HUMAN
A:
[55-352]
---
D
E
Y
E
I
I
E
T
I
G
N
G
A
Y
G
V
V
S
S
A
R
R
R
L
T
G
Q
Q
V
A
I
K
K
I
P
N
A
F
D
V
V
T
---
N
A
K
R
T
L
R
E
L
K
I
L
K
H
F
---
K
H
D
N
I
I
A
I
K
D
I
L
R
P
T
V
P
Y
G
E
-
F
K
S
V
Y
V
V
L
D
L
M
E
S
D
L
H
Q
I
I
H
S
--
S
--
Q
P
L
T
L
E
H
V
R
Y
F
L
Y
Q
L
L
R
G
L
K
Y
M
H
S
A
Q
V
I
H
R
D
L
K
P
S
N
L
L
V
N
E
-
N
C
E
L
K
I
G
D
F
G
M
A
R
G
L
C
T
S
PAEHQ
Y
-
F
M
T
E
Y
V
A
T
R
W
Y
R
A
P
E
L
M
L
S
L
H
E
-
Y
T
Q
A
I
D
L
W
S
V
G
C
I
F
G
E
M
L
A
-----------
R
R
Q
L
F
P
G
K
N
-------
Y
V
H
Q
L
Q
L
I
M
M
V
L
G
T
P
S
P
A
V
I
Q
A
V
G
A
-
E
R
VRAY-
I
---
Q
S
L
P
P
R
-
Q
P
-
V
P
W
-
E
T
V
Y
P
G
-
A
------------
D
R
Q
A
L
S
L
L
G
R
M
L
R
F
E
P
S
A
R
I
S
A
A
A
A
L
R
H
P
F
L
A
K
Y
H
D
P
D
D
126
HHSearch
65.56
36%
-99
- C1 -
3TTJ
1
MK10_HUMAN
A:
[61-361]
--
L
K
R
Y
Q
N
L
K
P
I
G
S
G
A
Q
G
I
V
C
A
A
Y
D
A
V
L
D
R
N
V
A
I
K
K
L
S
R
P
F
Q
N
Q
T
---
H
A
K
R
A
Y
R
E
L
V
L
M
K
C
V
---
N
H
K
N
I
I
S
L
L
N
V
F
T
P
Q
K
T
L
E
E
-
F
Q
D
V
Y
L
V
M
E
L
M
D
A
N
L
C
Q
V
I
Q
M
------
E
L
D
H
E
R
M
S
Y
L
L
Y
Q
M
L
C
G
I
K
H
L
H
S
A
G
I
I
H
R
D
L
K
P
S
N
I
V
V
K
S
-
D
C
T
L
K
I
L
D
F
G
L
A
-----
S
-----
F
-
M
M
----
V
T
R
Y
Y
R
A
P
E
V
I
L
G
M
-
G
-
Y
K
E
N
V
D
I
W
S
V
G
C
I
M
G
E
M
V
R
-----------
H
K
I
L
F
P
G
R
D
-------
Y
I
D
Q
W
N
K
V
I
E
Q
L
G
T
P
C
P
E
F
M
K
K
L
Q
P
-
T
V
R
N
Y
--
V
---
E
N
R
P
K
Y
-
A
G
-
L
T
F
-
P
K
L
F
P
D
-
S
LFPADS
E
H
N
K
L
K
A
S
Q
A
R
D
L
L
S
K
M
L
V
I
D
P
A
K
R
I
S
V
D
D
A
L
Q
H
P
Y
I
N
V
W
Y
D
P
A
E
128
HHSearch
65.35
36%
-115
- C1 -
2FST
3
MK14_HUMAN
X:
[29-318]
---
E
R
Y
Q
N
L
S
P
V
G
----
G
S
V
C
A
A
F
D
T
K
T
G
L
R
V
A
V
K
K
L
S
R
P
F
Q
S
I
I
---
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
---
H
E
N
V
I
G
L
L
D
V
F
T
P
A
R
S
-
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
----------
Q
K
L
T
D
D
H
V
Q
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
E
-
D
C
E
L
K
I
L
D
-----------------------
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
-
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
-----------
G
R
T
L
F
P
G
T
D
-------
H
I
D
Q
L
K
L
I
L
R
L
V
G
T
P
G
A
E
L
L
K
K
I
S
S
-
E
S
ARNY-
I
---
Q
S
L
T
Q
M
-
P
K
-
M
N
F
-
A
N
V
F
I
G
-
A
------------
N
P
L
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
35
PsiBlast_CBE
48.65
45%
-13
- C1 -
4FKO
1
CDK2_HUMAN
A:
[7-288]
-----
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
----------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
T
-------
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
--
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
-----
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
-
M
P
DY---
K
---
P
S
F
P
K
W
-
A
R
-
Q
D
F
-
S
K
V
V
P
P
-
L
------------
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
114
HHSearch
44.58
47%
-6
- C1 -
4EK4
1
CDK2_HUMAN
A:
[3-292]
-
E
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
------------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
---
N
H
P
N
I
V
K
L
L
D
V
I
H
T
-------
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
--
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
-----
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
-
M
P
DY---
K
---
P
S
F
P
K
W
-
A
R
-
Q
D
F
-
S
K
V
V
P
P
-
L
------------
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
38
PsiBlast_CBE
42.89
45%
-8
- C1 -
4FKG
1
CDK2_HUMAN
A:
[7-288]
-----
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
------------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
T
-------
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
--
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
--------R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
-
M
P
DY---
K
---
P
S
F
P
K
W
-
A
R
-
Q
D
F
-
S
K
V
V
P
P
-
L
------------
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
60
PsiBlast_CBE
42.84
45%
-14
- C1 -
3IGG
1
CDK2_HUMAN
A:
[7-288]
-----
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
-----------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
T
-------
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
--
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
-----
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
-
M
P
DY---
K
---
P
S
F
P
K
W
-
A
R
-
Q
D
F
-
S
K
V
V
P
P
-
L
------------
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
31
PsiBlast_CBE
42.77
45%
-9
- C1 -
4FKV
2
CDK2_HUMAN
A:
[7-288]
-----
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-----
G
---
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
T
-------
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
--
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
----------------
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
-
M
P
DY---
K
---
P
S
F
P
K
W
-
A
R
-
Q
D
F
-
S
K
V
V
P
P
-
L
------------
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
33
PsiBlast_CBE
42.00
45%
-12
- C1 -
4FKQ
2
CDK2_HUMAN
A:
[7-288]
-----
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
---------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
T
-------
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
--
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
--------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
-
M
P
DY---
K
---
P
S
F
P
K
W
-
A
R
-
Q
D
F
-
S
K
V
V
P
P
-
L
------------
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
40
PsiBlast_CBE
41.52
45%
-11
- C1 -
4EK6
1
CDK2_HUMAN
A:
[7-288]
-----
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
-------------
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
T
-------
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
--
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
---------------
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
-
M
P
DY---
K
---
P
S
F
P
K
W
-
A
R
-
Q
D
F
-
S
K
V
V
P
P
-
L
------------
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
41
PsiBlast_CBE
41.47
45%
-13
- C1 -
4EK5
1
CDK2_HUMAN
A:
[7-288]
-----
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
------------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
T
-------
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
--
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
-----
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
-
M
P
DY---
K
---
P
S
F
P
K
W
-
A
R
-
Q
D
F
-
S
K
V
V
P
P
-
L
------------
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
32
PsiBlast_CBE
40.75
45%
-9
- C1 -
4FKR
2
CDK2_HUMAN
A:
[7-288]
-----
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
----------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
T
-------
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
--
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
--------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
-
M
P
DY---
K
---
P
S
F
P
K
W
-
A
R
-
Q
D
F
-
S
K
V
V
P
P
-
L
------------
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
37
PsiBlast_CBE
40.37
45%
-10
- C1 -
4FKJ
1
CDK2_HUMAN
A:
[7-288]
-----
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
------------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
T
-------
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
--
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
----------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
-
M
P
DY---
K
---
P
S
F
P
K
W
-
A
R
-
Q
D
F
-
S
K
V
V
P
P
-
L
------------
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
61
PsiBlast_CBE
39.83
45%
-8
- C1 -
3IG7
1
CDK2_HUMAN
A:
[7-288]
-----
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
-----------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
T
-------
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
--
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
-----------------
T
L
W
Y
R
A
P
E
I
L
L
G
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
-
M
P
DY---
K
---
P
S
F
P
K
W
-
A
R
-
Q
D
F
-
S
K
V
V
P
P
-
L
------------
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
80
PsiBlast_CBE
39.72
45%
-6
- C1 -
2VV9
1
CDK2_HUMAN
A:
[7-288]
-----
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
---------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
T
-------
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
--
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
-
M
P
DY---
K
---
P
S
F
P
K
W
-
A
R
-
Q
D
F
-
S
K
V
V
P
P
-
L
------------
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
53
PsiBlast_CBE
39.50
45%
-10
- C1 -
3SW7
1
CDK2_HUMAN
A:
[7-288]
-----
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
----------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
T
-------
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
--
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
-
M
P
DY---
K
---
P
S
F
P
K
W
-
A
R
-
Q
D
F
-
S
K
V
V
P
P
-
L
------------
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
77
PsiBlast_CBE
38.99
45%
-6
- C1 -
2W17
1
CDK2_HUMAN
A:
[7-288]
-----
F
Q
K
V
E
K
I
G
E
-
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
--------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
T
-------
E
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
--
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
-
M
P
DY---
K
---
P
S
F
P
K
W
-
A
R
-
Q
D
F
-
S
K
V
V
P
P
-
L
------------
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P