@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : CDK6_HUMAN: (2015-10-05 )
MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA
Atome Classification :
(96 SA)
.........10........20........30........40........50........60........70........80.......-.90........100.......110--.......120.......130.......140.......150...-....160.......170.-----.-.....180.......190..-.-....200.......210..-----------.....220.-------......230.......240......-.250---.---.......-.260-......-.------------270.......280.......290.......300.......310.......320....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MEKDGLCRA
D
Q
Q
Y
E
C
V
A
E
IGEGAYG
K
V
F
K
ARDLKNG
G
R
F
V
A
L
K
R
V
R
VQTGEEGM
P
L
S
T
I
R
E
V
A
V
L
R
H
L
E
T
FEHP
N
V
V
R
L
F
D
V
C
TVSRT-DRE
T
K
L
T
L
V
F
E
H
VD
Q
D
L
T
T
Y
L
D
KV--PEPGV
P
T
E
T
I
K
D
M
M
F
Q
L
L
R
G
L
D
F
L
H
S
H
R
V
V
H
RDLKPQ
N
I
L
V
TS-SG
Q
I
K
L
A
D
F
G
L
A
R
I
Y
S
F
Q
-----
M
-
A
L
T
S
V
V
V
T
L
W
YRA
P
E
V
L
L
QS-S-YAT
P
V
D
L
W
S
V
G
C
I
F
A
E
M
F
R-----------RKPLFRGSS-------
D
V
D
Q
L
G
K
I
L
D
V
IGLPGEEDWPRDVA-L
P
-----
R
---
Q
A
FHSKS-A
Q
P
I
-
E
K
F
V
T
D
-
I
------------
D
E
L
G
K
D
L
L
L
K
C
LTFN
P
A
K
R
I
S
A
Y
S
ALS
H
P
Y
F
Q
D
L
E
R
C
K
E
N
L
D
SHLPPSQNTSELNTA
12
PsiBlast_PDB
92.26
100%
-136
- C1 -
4EZ5
1
CDK6_HUMAN
A:
[11-301]
----------
Q
Q
Y
E
C
V
A
E
I
G
E
G
A
-
G
K
V
F
K
A
R
D
L
K
N
G
G
R
F
V
A
L
K
R
V
---------
P
L
S
T
I
R
E
V
A
V
L
R
H
L
E
T
F
E
H
P
N
V
V
R
L
F
D
V
C
---------
T
K
L
T
L
V
F
E
H
V
D
Q
D
L
T
T
Y
L
D
K
V
--
P
E
P
G
V
P
T
E
T
I
K
D
M
M
F
Q
L
L
R
G
L
D
F
L
H
S
H
R
V
V
H
R
D
L
K
P
Q
N
I
L
V
T
S
-
S
G
Q
I
K
L
A
D
F
G
L
A
-------------------
V
T
L
W
Y
R
A
P
E
V
L
L
Q
S
-
S
-
Y
A
T
P
V
D
L
W
S
V
G
C
I
F
A
E
M
F
R
-----------
R
K
P
L
F
R
G
S
S
-------
D
V
D
Q
L
G
K
I
L
D
V
I
G
L
P
G
E
E
D
W
P
R
D
V
A
-
L
P
-----
R
---
Q
A
F
H
S
---
A
Q
P
I
-
E
K
F
V
T
D
-
I
------------
D
E
L
G
K
D
L
L
L
K
C
L
T
F
N
P
A
K
R
I
S
A
Y
S
A
L
S
H
P
Y
F
Q
-------------------------
10
PsiBlast_PDB
92.25
100%
-133
- C1 -
3NUX
1
CDK6_HUMAN
A:
[10-301]
---------
D
Q
Q
Y
E
C
V
A
E
I
G
E
G
A
-
G
K
V
F
K
A
R
D
L
K
N
G
G
R
F
V
A
L
K
R
V
R
--------
P
L
S
T
I
R
E
V
A
V
L
R
H
L
E
T
F
E
H
P
N
V
V
R
L
F
D
V
C
---------
T
K
L
T
L
V
F
E
H
V
D
Q
D
L
T
T
Y
L
D
K
V
--
P
E
P
G
V
P
T
E
T
I
K
D
M
M
F
Q
L
L
R
G
L
D
F
L
H
S
H
R
V
V
H
R
D
L
K
P
Q
N
I
L
V
T
S
-
S
G
Q
I
K
L
A
D
F
G
L
A
-------------------
V
T
L
W
Y
R
A
P
E
V
L
L
Q
S
-
S
-
Y
A
T
P
V
D
L
W
S
V
G
C
I
F
A
E
M
F
R
-----------
R
K
P
L
F
R
G
S
S
-------
D
V
D
Q
L
G
K
I
L
D
V
I
G
L
P
G
E
E
D
W
P
R
D
V
A
-
L
P
-----
R
---
Q
A
F
H
-
K
S
-
A
Q
P
I
-
E
K
F
V
T
D
-
I
------------
D
E
L
G
K
D
L
L
L
K
C
L
T
F
N
P
A
K
R
I
S
A
Y
S
A
L
S
H
P
Y
F
Q
-------------------------
7
PsiBlast_PDB
92.11
100%
-128
- C1 -
1XO2
1
CDK6_HUMAN
B:
[11-305]
----------
Q
Q
Y
E
C
V
A
E
I
G
E
G
A
Y
G
K
V
F
K
A
R
D
L
K
N
G
G
R
F
V
A
L
K
R
V
R
V
Q
T
G
E
E
G
M
P
L
S
T
I
R
E
V
A
V
L
R
H
L
E
T
F
E
H
P
N
V
V
R
L
F
D
V
C
T
V
S
----
R
E
T
K
L
T
L
V
F
E
H
V
D
Q
D
L
T
T
Y
L
D
K
V
--
P
E
P
G
V
P
T
E
T
I
K
D
M
M
F
Q
L
L
R
G
L
D
F
L
H
S
H
R
V
V
H
R
D
L
K
P
Q
N
I
L
V
T
S
-
S
G
Q
I
K
L
A
D
F
G
L
A
R
I
Y
S
F
Q
-----
M
-
A
L
T
S
V
V
V
T
L
W
Y
R
A
P
E
V
L
L
Q
S
-
S
-
Y
A
T
P
V
D
L
W
S
V
G
C
I
F
A
E
M
F
R
-----------
R
K
P
L
F
R
G
S
S
-------
D
V
D
Q
L
G
K
I
L
D
V
I
G
L
P
G
E
E
D
W
P
R
D
V
A
-
L
P
-----
R
---
Q
A
F
H
----
A
Q
P
I
-
E
K
F
V
T
D
-
I
------------
D
E
L
G
K
D
L
L
L
K
C
L
T
F
N
P
A
K
R
I
S
A
Y
S
A
L
S
H
P
Y
F
Q
D
L
E
R
---------------------
11
PsiBlast_PDB
90.49
100%
-136
- C1 -
4AUA
1
CDK6_HUMAN
A:
[11-301]
----------
Q
Q
Y
E
C
V
A
E
I
G
E
G
A
-
G
K
V
F
K
A
R
D
L
K
N
G
G
R
F
V
A
L
K
R
------------
S
T
I
R
E
V
A
V
L
R
H
L
E
T
F
E
H
P
N
V
V
R
L
F
D
V
C
---------
T
K
L
T
L
V
F
E
H
V
D
Q
D
L
T
T
Y
L
D
K
V
--
P
E
P
G
V
P
T
E
T
I
K
D
M
M
F
Q
L
L
R
G
L
D
F
L
H
S
H
R
V
V
H
R
D
L
K
P
Q
N
I
L
V
T
S
-
S
G
Q
I
K
L
A
D
F
G
L
A
--------------------
T
L
W
Y
R
A
P
E
V
L
L
Q
S
-
S
-
Y
A
T
P
V
D
L
W
S
V
G
C
I
F
A
E
M
F
R
-----------
R
K
P
L
F
R
G
S
S
-------
D
V
D
Q
L
G
K
I
L
D
V
I
G
L
P
G
E
E
D
W
P
R
D
V
A
-
L
P
-----
R
---
Q
A
F
H
S
K
S
-
A
Q
P
I
-
E
K
F
V
T
D
-
I
------------
D
E
L
G
K
D
L
L
L
K
C
L
T
F
N
P
A
K
R
I
S
A
Y
S
A
L
S
H
P
Y
F
Q
-------------------------
8
PsiBlast_PDB
90.20
100%
-130
- C1 -
2EUF
2
CDK6_HUMAN
B:
[10-305]
---------
D
Q
Q
Y
E
C
V
A
E
I
G
E
G
A
Y
G
K
V
F
K
A
R
D
L
K
N
G
G
R
F
V
A
L
K
R
V
R
V
Q
T
G
E
E
G
M
P
L
S
T
I
R
E
V
A
V
L
R
H
L
E
T
F
E
H
P
N
V
V
R
L
F
D
V
C
T
V
S
R
T
-
D
R
E
T
K
L
T
L
V
F
E
H
V
D
Q
D
L
T
T
Y
L
D
K
V
--
P
E
P
G
V
P
T
E
T
I
K
D
M
M
F
Q
L
L
R
G
L
D
F
L
H
S
H
R
V
V
H
R
D
L
K
P
Q
N
I
L
V
T
S
-
S
G
Q
I
K
L
A
D
F
G
L
A
R
I
Y
S
F
Q
-----
M
-
A
L
T
S
V
V
V
T
L
W
Y
R
A
P
E
V
L
L
Q
S
-
S
-
Y
A
T
P
V
D
L
W
S
V
G
C
I
F
A
E
M
F
R
-----------
R
K
P
L
F
R
G
S
S
-------
D
V
D
Q
L
G
K
I
L
D
V
I
G
L
P
G
E
E
D
W
P
------------------------
A
Q
P
I
-
E
K
F
V
T
D
-
I
------------
D
E
L
G
K
D
L
L
L
K
C
L
T
F
N
P
A
K
R
I
S
A
Y
S
A
L
S
H
P
Y
F
Q
D
L
E
R
---------------------
9
PsiBlast_PDB
89.64
100%
-129
- C1 -
2F2C
2
CDK6_HUMAN
B:
[9-305]
--------
A
D
Q
Q
Y
E
C
-
A
E
I
G
----
G
K
V
F
K
A
R
D
L
K
N
G
G
R
F
V
A
L
K
R
V
R
V
Q
T
G
E
E
G
M
P
L
S
T
I
R
E
V
A
V
L
R
H
L
E
T
F
E
H
P
N
V
V
R
L
F
D
V
C
T
V
S
-
T
-
D
R
E
T
K
L
T
L
V
F
E
H
V
D
Q
D
L
T
T
Y
L
D
K
V
--
P
E
P
G
V
P
T
E
T
I
K
D
M
M
F
Q
L
L
R
G
L
D
F
L
H
S
H
R
V
V
H
R
D
L
K
P
Q
N
I
L
V
T
S
-
S
G
Q
I
K
L
A
D
F
G
L
A
R
I
Y
S
F
Q
-----
M
-
A
L
T
S
V
V
V
T
L
W
Y
R
A
P
E
V
L
L
Q
S
-
S
-
Y
A
T
P
V
D
L
W
S
V
G
C
I
F
A
E
M
F
R
-----------
R
K
P
L
F
R
G
S
S
-------
D
V
D
Q
L
G
K
I
L
D
V
I
G
L
P
G
E
E
D
W
P
----------------
Q
A
F
-----
A
Q
P
I
-
E
K
F
V
T
D
-
I
------------
D
E
L
G
K
D
L
L
L
K
C
L
T
F
N
P
A
K
R
I
S
A
Y
S
A
L
S
H
P
Y
F
Q
D
L
E
R
---------------------
5
PsiBlast_PDB
87.04
100%
-134
- C1 -
4TTH
1
CDK6_HUMAN
B:
[15-304]
--------------
C
V
A
E
I
G
E
----
K
V
F
K
A
R
D
L
K
N
G
-
R
F
V
A
L
K
R
V
R
V
----
E
G
M
P
L
S
T
I
R
E
V
A
V
L
R
H
L
E
T
F
E
H
P
N
V
V
R
L
F
D
V
C
T
--------
T
K
L
T
L
V
F
E
H
V
D
Q
D
L
T
T
Y
L
D
K
V
--
P
E
P
G
V
P
T
E
T
I
K
D
M
M
F
Q
L
L
R
G
L
D
F
L
H
S
H
R
V
V
H
R
D
L
K
P
Q
N
I
L
V
T
S
-
S
G
Q
I
K
L
A
D
F
G
L
A
R
I
Y
S
F
Q
-----
M
-
A
L
T
S
V
V
V
T
L
W
Y
R
A
P
E
V
L
L
Q
S
-
S
-
Y
A
T
P
V
D
L
W
S
V
G
C
I
F
A
E
M
F
R
-----------
R
K
P
L
F
R
G
S
S
-------
D
V
D
Q
L
G
K
I
L
D
V
I
G
L
P
G
E
E
D
W
P
--------------------------
P
I
-
E
K
F
--
D
-
I
------------
D
E
L
G
K
D
L
L
L
K
C
L
T
F
N
P
A
K
R
I
S
A
Y
S
A
L
S
H
P
Y
F
Q
D
L
E
----------------------
87
PsiBlast_CBE
79.97
48%
-120
- C1 -
2VTO
1
CDK2_HUMAN
A:
[2-291]
----------
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
-------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
T
------
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
--
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
-------------
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
-
M
P
DY---
K
---
P
S
F
P
K
W
A
-
R
Q
D
F
-
S
K
V
V
P
P
-
L
------------
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
--------------
44
PsiBlast_CBE
79.63
48%
-125
- C1 -
4D1X
1
CDK2_HUMAN
A:
[3-291]
-----------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
-----------
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
T
------
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
--
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
----------------
T
L
W
Y
R
A
P
E
I
L
L
G
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
-
M
P
DY---
K
---
P
S
F
P
K
W
A
-
R
Q
D
F
-
S
K
V
V
P
P
-
L
------------
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
--------------
63
PsiBlast_CBE
79.13
48%
-118
- C1 -
3FZ1
1
CDK2_HUMAN
A:
[2-291]
----------
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
-------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
T
------
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
--
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
------------
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
-
M
P
DY---
K
---
P
S
F
P
K
W
A
-
R
Q
D
F
-
S
K
V
V
P
P
-
L
------------
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
--------------
57
PsiBlast_CBE
79.08
48%
-122
- C1 -
3NS9
1
CDK2_HUMAN
A:
[3-291]
-----------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
-------
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
T
------
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
--
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
-----
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
-
M
P
DY---
K
---
P
S
F
P
K
W
A
-
R
Q
D
F
-
S
K
V
V
P
P
-
L
------------
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
--------------
79
PsiBlast_CBE
78.88
48%
-122
- C1 -
2W06
2
CDK2_HUMAN
A:
[2-291]
----------
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
-------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
T
------
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
--
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
--------------
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
-
M
P
DY---
K
---
P
S
F
P
K
W
A
-
R
Q
D
F
-
S
K
V
V
P
P
-
L
------------
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
--------------
19
PsiBlast_PDB
78.65
49%
-119
- C1 -
1GIJ
1
CDK2_HUMAN
A:
[2-291]
----------
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
-----------
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
T
------
E
N
K
L
Y
L
V
F
E
H
V
H
Q
D
L
K
T
F
M
D
A
S
--
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
-------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
-
M
P
DY---
K
---
P
S
F
P
K
W
A
-
R
Q
D
F
-
S
K
V
V
P
P
-
L
------------
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
--------------
60
PsiBlast_CBE
78.58
48%
-118
- C1 -
3LFN
1
CDK2_HUMAN
A:
[2-291]
----------
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
T
------
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
--
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
--------------
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
-
M
P
DY---
K
---
P
S
F
P
K
W
A
-
R
Q
D
F
-
S
K
V
V
P
P
-
L
------------
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
--------------
24
PsiBlast_CBE
78.45
48%
-119
- C1 -
3PJ8
1
CDK2_HUMAN
A:
[3-292]
----------
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
---
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
T
------
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
--
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
-------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
-
M
P
DY---
K
---
P
S
F
P
K
W
A
-
R
Q
D
F
-
S
K
V
V
P
P
-
L
------------
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
--------------
27
PsiBlast_CBE
78.44
48%
-116
- C1 -
4LYN
1
CDK2_HUMAN
A:
[2-291]
----------
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
T
------
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
--
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
----------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
-
M
P
DY---
K
---
P
S
F
P
K
W
A
-
R
Q
D
F
-
S
K
V
V
P
P
-
L
------------
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
--------------
94
PsiBlast_CBE
78.31
48%
-118
- C1 -
2VTA
3
CDK2_HUMAN
A:
[2-291]
----------
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
---------
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
T
------
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
--
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
----------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
-
M
P
DY---
K
---
P
S
F
P
K
W
A
-
R
Q
D
F
-
S
K
V
V
P
P
-
L
------------
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
--------------
28
PsiBlast_CBE
78.27
48%
-117
- C1 -
4KD1
2
CDK2_HUMAN
A:
[2-291]
----------
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
T
------
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
--
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
-----
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
-
M
P
DY---
K
---
P
S
F
P
K
W
A
-
R
Q
D
F
-
S
K
V
V
P
P
-
L
------------
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
--------------
93
PsiBlast_CBE
78.26
48%
-123
- C1 -
2VTH
2
CDK2_HUMAN
A:
[2-291]
----------
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
---------
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
T
------
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
--
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
----------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
-
M
P
DY---
K
---
P
S
F
P
K
W
A
-
R
Q
D
F
-
S
K
V
V
P
P
-
L
------------
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
--------------
50
PsiBlast_CBE
78.24
48%
-120
- C1 -
3ULI
1
CDK2_HUMAN
A:
[2-291]
----------
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-----
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
T
------
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
--
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
------------
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
-
M
P
DY---
K
---
P
S
F
P
K
W
A
-
R
Q
D
F
-
S
K
V
V
P
P
-
L
------------
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
--------------
46
PsiBlast_CBE
78.24
48%
-120
- C1 -
4BGH
1
CDK2_HUMAN
A:
[2-291]
----------
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
---------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
T
------
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
--
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
-------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
-
M
P
DY---
K
---
P
S
F
P
K
W
A
-
R
Q
D
F
-
S
K
V
V
P
P
-
L
------------
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
--------------
83
PsiBlast_CBE
78.21
48%
-120
- C1 -
2VTS
1
CDK2_HUMAN
A:
[2-291]
----------
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
--------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
T
------
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
--
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
-------------
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
-
M
P
DY---
K
---
P
S
F
P
K
W
A
-
R
Q
D
F
-
S
K
V
V
P
P
-
L
------------
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
--------------
92
PsiBlast_CBE
78.18
48%
-122
- C1 -
2VTI
1
CDK2_HUMAN
A:
[2-291]
----------
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
--------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
T
------
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
--
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
---------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
-
M
P
DY---
K
---
P
S
F
P
K
W
A
-
R
Q
D
F
-
S
K
V
V
P
P
-
L
------------
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
--------------
97
PsiBlast_CBE
78.15
48%
-125
- C1 -
2UZN
1
CDK2_HUMAN
A:
[2-291]
----------
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
---------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
T
------
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
--
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
---------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
-
M
P
DY---
K
---
P
S
F
P
K
W
A
-
R
Q
D
F
-
S
K
V
V
P
P
-
L
------------
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
--------------
86
PsiBlast_CBE
78.13
48%
-119
- C1 -
2VTP
1
CDK2_HUMAN
A:
[2-291]
----------
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
--------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
T
------
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
--
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
--------------
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
-
M
P
DY---
K
---
P
S
F
P
K
W
A
-
R
Q
D
F
-
S
K
V
V
P
P
-
L
------------
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
--------------
18
PsiBlast_PDB
78.09
49%
-121
- C1 -
1GII
1
CDK2_HUMAN
A:
[2-291]
----------
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
--------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
T
------
E
N
K
L
Y
L
V
F
E
H
V
H
Q
D
L
K
T
F
M
D
A
S
--
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
----------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
-
M
P
DY---
K
---
P
S
F
P
K
W
A
-
R
Q
D
F
-
S
K
V
V
P
P
-
L
------------
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
--------------
23
PsiBlast_CBE
78.08
48%
-118
- C1 -
3EZR
2
CDK2_HUMAN
A:
[4-293]
----------
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
-------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
T
------
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
--
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
-----------------------
T
L
W
Y
R
A
P
E
I
L
L
G
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
-
M
P
DY---
K
---
P
S
F
P
K
W
A
-
R
Q
D
F
-
S
K
V
V
P
P
-
L
------------
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
--------------
72
PsiBlast_CBE
78.06
48%
-116
- C1 -
2XMY
1
CDK2_HUMAN
A:
[2-291]
----------
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
---
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
T
------
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
--
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
-----
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
-
M
P
DY---
K
---
P
S
F
P
K
W
A
-
R
Q
D
F
-
S
K
V
V
P
P
-
L
------------
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
--------------
56
PsiBlast_CBE
78.05
48%
-123
- C1 -
3S2P
1
CDK2_HUMAN
A:
[2-291]
----------
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
--------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
T
------
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
--
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
----------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
-
M
P
DY---
K
---
P
S
F
P
K
W
A
-
R
Q
D
F
-
S
K
V
V
P
P
-
L
------------
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
--------------
100
PsiBlast_CBE
78.04
48%
-123
- C1 -
2R64
1
CDK2_HUMAN
A:
[2-291]
----------
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
--------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
T
------
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
--
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
----------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
-
M
P
DY---
K
---
P
S
F
P
K
W
A
-
R
Q
D
F
-
S
K
V
V
P
P
-
L
------------
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
--------------
69
PsiBlast_CBE
78.04
48%
-122
- C1 -
3EJ1
1
CDK2_HUMAN
A:
[2-291]
----------
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
---
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
T
------
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
--
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
-----
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
-
M
P
DY---
K
---
P
S
F
P
K
W
A
-
R
Q
D
F
-
S
K
V
V
P
P
-
L
------------
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
--------------
59
PsiBlast_CBE
77.93
48%
-119
- C1 -
3LFQ
1
CDK2_HUMAN
A:
[2-291]
----------
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
---------
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
T
------
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
--
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
-----
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
-
M
P
DY---
K
---
P
S
F
P
K
W
A
-
R
Q
D
F
-
S
K
V
V
P
P
-
L
------------
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
--------------
30
PsiBlast_CBE
77.89
48%
-119
- C1 -
4FX3
2
CDK2_HUMAN
A:
[2-291]
----------
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
T
------
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
--
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
-----
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
-
M
P
DY---
K
---
P
S
F
P
K
W
A
-
R
Q
D
F
-
S
K
V
V
P
P
-
L
------------
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
--------------
29
PsiBlast_CBE
77.80
48%
-116
- C1 -
4FX3
1
CDK2_HUMAN
C:
[2-291]
----------
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
T
------
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
--
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
-----
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
-
M
P
DY---
K
---
P
S
F
P
K
W
A
-
R
Q
D
F
-
S
K
V
V
P
P
-
L
------------
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
--------------
70
PsiBlast_CBE
77.76
48%
-123
- C1 -
3EID
1
CDK2_HUMAN
A:
[2-291]
----------
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
---
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
T
------
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
--
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
-----
V
R
T
Y
T
--
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
-
M
P
DY---
K
---
P
S
F
P
K
W
A
-
R
Q
D
F
-
S
K
V
V
P
P
-
L
------------
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
---------------
66
PsiBlast_CBE
77.66
48%
-121
- C1 -
3EOC
1
CDK2_HUMAN
C:
[2-291]
----------
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
---
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
T
------
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
--
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
-----
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
-
M
P
DY---
K
---
P
S
F
P
K
W
A
-
R
Q
D
F
-
S
K
V
V
P
P
-
L
------------
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
----------------
58
PsiBlast_CBE
77.64
48%
-120
- C1 -
3LFS
1
CDK2_HUMAN
A:
[2-291]
----------
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
--------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
T
------
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
--
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
-----
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
-
M
P
DY---
K
---
P
S
F
P
K
W
A
-
R
Q
D
F
-
S
K
V
V
P
P
-
L
------------
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
--------------
95
PsiBlast_CBE
77.63
48%
-123
- C1 -
2V0D
1
CDK2_HUMAN
A:
[2-291]
----------
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
T
------
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
--
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
-----
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
-
M
P
DY---
K
---
P
S
F
P
K
W
A
-
R
Q
D
F
-
S
K
V
V
P
P
-
L
------------
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
--------------
65
PsiBlast_CBE
77.60
48%
-120
- C1 -
3F5X
2
CDK2_HUMAN
A:
[2-291]
----------
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
T
------
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
--
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
-----
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
-
M
P
DY---
K
---
P
S
F
P
K
W
A
-
R
Q
D
F
-
S
K
V
V
P
P
-
L
------------
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
-
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
--------------
64
PsiBlast_CBE
77.58
48%
-119
- C1 -
3F5X
2
CDK2_HUMAN
C:
[2-291]
----------
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
T
------
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
--
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
-----
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
-
M
P
DY---
K
---
P
S
F
P
K
W
A
-
R
Q
D
F
-
S
K
V
V
P
P
-
L
------------
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
--------------
91
PsiBlast_CBE
77.55
48%
-118
- C1 -
2VTJ
2
CDK2_HUMAN
A:
[2-291]
----------
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
---------
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
T
------
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
--
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
-
M
P
DY---
K
---
P
S
F
P
K
W
A
-
R
Q
D
F
-
S
K
V
V
P
P
-
L
------------
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
--------------
67
PsiBlast_CBE
77.55
48%
-121
- C1 -
3EOC
1
CDK2_HUMAN
A:
[2-291]
----------
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
---
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
T
------
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
--
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
-----
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
-
M
P
DY---
K
---
P
S
F
P
K
W
A
-
R
Q
D
F
-
S
K
V
V
P
P
-
L
------------
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
--------------
47
PsiBlast_CBE
77.52
48%
-120
- C1 -
3WBL
1
CDK2_HUMAN
A:
[2-291]
----------
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
-
T
G
E
V
V
A
L
K
K
I
R
L
-----
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
T
------
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
--
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
--------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
-
M
P
DY---
K
---
P
S
F
P
K
W
A
-
R
Q
D
F
-
S
K
V
V
P
P
-
L
------------
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
--------------
77
PsiBlast_CBE
77.48
48%
-116
- C1 -
2W1H
1
CDK2_HUMAN
A:
[2-291]
----------
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
T
------
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
--
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
----------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
-
M
P
DY---
K
---
P
S
F
P
K
W
A
-
R
Q
D
F
-
S
K
V
V
P
P
-
L
------------
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
--------------
22
PsiBlast_CBE
77.44
48%
-115
- C1 -
3EZV
1
CDK2_HUMAN
A:
[4-293]
----------
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
-------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
T
------
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
--
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
-------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
-
M
P
DY---
K
---
P
S
F
P
K
W
A
-
R
Q
D
F
-
S
K
V
V
P
P
-
L
------------
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
--------------
71
PsiBlast_CBE
77.42
48%
-115
- C1 -
2XNB
1
CDK2_HUMAN
A:
[2-291]
----------
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
--
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
T
------
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
--
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
-----
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
-
M
P
DY---
K
---
P
S
F
P
K
W
A
-
R
Q
D
F
-
S
K
V
V
P
P
-
L
------------
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
--------------
84
PsiBlast_CBE
77.35
48%
-119
- C1 -
2VTR
1
CDK2_HUMAN
A:
[2-291]
----------
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
--------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
T
------
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
--
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
-----
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
-
M
P
DY---
K
---
P
S
F
P
K
W
A
-
R
Q
D
F
-
S
K
V
V
P
P
-
L
------------
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
--------------
52
PsiBlast_CBE
77.34
48%
-118
- C1 -
3TIY
12
CDK2_HUMAN
A:
[2-291]
----------
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
T
------
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
--
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
-----
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
-
M
P
DY---
K
---
P
S
F
P
K
W
A
-
R
Q
D
F
-
S
K
V
V
P
P
-
L
------------
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
--------------
90
PsiBlast_CBE
77.32
48%
-116
- C1 -
2VTL
1
CDK2_HUMAN
A:
[2-291]
----------
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
--------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
T
------
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
--
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
-----
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
-
M
P
DY---
K
---
P
S
F
P
K
W
A
-
R
Q
D
F
-
S
K
V
V
P
P
-
L
------------
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
--------------
53
PsiBlast_CBE
77.30
48%
-118
- C1 -
3TI1
9
CDK2_HUMAN
A:
[2-291]
----------
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
T
------
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
--
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
-----
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
-
M
P
DY---
K
---
P
S
F
P
K
W
A
-
R
Q
D
F
-
S
K
V
V
P
P
-
L
------------
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
--------------
96
PsiBlast_CBE
77.28
48%
-120
- C1 -
2UZO
1
CDK2_HUMAN
A:
[2-291]
----------
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
T
------
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
--
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
-----
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
-
M
P
DY---
K
---
P
S
F
P
K
W
A
-
R
Q
D
F
-
S
K
V
V
P
P
-
L
------------
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
----------------
51
PsiBlast_CBE
77.27
48%
-120
- C1 -
3TIZ
9
CDK2_HUMAN
A:
[2-291]
----------
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
T
------
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
--
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
-----
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
-
M
P
DY---
K
---
P
S
F
P
K
W
A
-
R
Q
D
F
-
S
K
V
V
P
P
-
L
------------
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
--------------
99
PsiBlast_CBE
77.16
48%
-117
- C1 -
2UUE
1
CDK2_HUMAN
A:
[2-291]
----------
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
T
------
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
--
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
-----
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
-
M
P
DY---
K
---
P
S
F
P
K
W
A
-
R
Q
D
F
-
S
K
V
V
P
P
-
L
------------
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
----------------
73
PsiBlast_CBE
77.16
48%
-118
- C1 -
2X1N
1
CDK2_HUMAN
C:
[2-291]
----------
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
T
------
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
--
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
-----
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
-
M
P
DY---
K
---
P
S
F
P
K
W
A
-
R
Q
D
F
-
S
K
V
V
P
P
-
L
------------
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
---------------
45
PsiBlast_CBE
77.09
48%
-118
- C1 -
4BZD
1
CDK2_HUMAN
A:
[3-292]
----------
E
N
F
Q
K
V
E
K
I
G
E
G
-
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
T
------
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
--
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
-------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
-
M
P
DY---
K
---
P
S
F
P
K
W
A
-
R
Q
D
F
-
S
K
V
V
P
P
-
L
------------
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
--------------
68
PsiBlast_CBE
77.08
48%
-121
- C1 -
3EJ1
1
CDK2_HUMAN
C:
[2-291]
----------
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
---
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
T
------
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
--
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
-----
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
-
M
P
DY---
K
---
P
S
F
P
K
W
A
-
R
Q
D
F
-
S
K
V
V
P
P
-
L
------------
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
---------------
49
PsiBlast_CBE
77.05
48%
-119
- C1 -
3UNJ
1
CDK2_HUMAN
A:
[2-291]
----------
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
T
------
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
--
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
-----
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
-
M
P
DY---
K
---
P
S
F
P
K
W
A
-
R
Q
D
F
-
S
K
V
V
P
P
-
L
------------
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
--------------
98
PsiBlast_CBE
77.02
48%
-116
- C1 -
2UUE
1
CDK2_HUMAN
C:
[2-291]
----------
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
T
------
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
--
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
-----
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
-
M
P
DY---
K
---
P
S
F
P
K
W
A
-
R
Q
D
F
-
S
K
V
V
P
P
-
L
------------
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
---------------
75
PsiBlast_CBE
77.01
48%
-113
- C1 -
2WEV
1
CDK2_HUMAN
C:
[2-291]
----------
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
T
------
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
--
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
-----
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
-
M
P
DY---
K
---
P
S
F
P
K
W
A
-
R
Q
D
F
-
S
K
V
V
P
P
-
L
------------
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
---------------
85
PsiBlast_CBE
76.98
48%
-119
- C1 -
2VTQ
1
CDK2_HUMAN
A:
[2-291]
----------
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
---------
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
T
------
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
--
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
--------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
-
M
P
DY---
K
---
P
S
F
P
K
W
A
-
R
Q
D
F
-
S
K
V
V
P
P
-
L
------------
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
--------------
21
PsiBlast_CBE
76.97
48%
-124
- C1 -
1OIT
1
CDK2_HUMAN
A:
[3-291]
-----------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
-
G
E
V
V
A
L
K
K
I
-----------
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
T
------
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
--
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
S
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
----------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
-
M
P
DY---
K
---
P
S
F
P
K
W
A
-
R
Q
D
F
-
S
K
V
V
P
P
-
L
------------
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
--------------
26
PsiBlast_CBE
76.72
48%
-118
- C1 -
5A14
2
?
A:
[3-292]
----------
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
--
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
T
------
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
--
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
---------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
-
M
P
DY---
K
---
P
S
F
P
K
W
A
-
R
Q
D
F
-
S
K
V
V
P
P
-
L
------------
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
----------------
48
PsiBlast_CBE
76.70
48%
-116
- C1 -
3UNK
1
CDK2_HUMAN
A:
[2-291]
----------
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
---
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
T
------
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
--
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
-----
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
-
M
P
DY---
K
---
P
S
F
P
K
W
A
-
R
Q
D
F
-
S
K
V
V
P
P
-
L
------------
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
--------------
80
PsiBlast_CBE
76.48
48%
-119
- C1 -
2W05
1
CDK2_HUMAN
A:
[2-291]
----------
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
---------
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
T
------
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
--
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
------------------
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
-
M
P
DY---
K
---
P
S
F
P
K
W
A
-
R
Q
D
F
-
S
K
V
V
P
P
-
L
------------
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
--------------
74
PsiBlast_CBE
76.48
48%
-118
- C1 -
2X1N
1
CDK2_HUMAN
A:
[2-291]
----------
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
T
------
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
--
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
-----
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
-
M
P
DY---
K
---
P
S
F
P
K
W
A
-
R
Q
D
F
-
S
K
V
V
P
P
-
L
------------
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
----------------
89
PsiBlast_CBE
76.31
48%
-119
- C1 -
2VTM
1
CDK2_HUMAN
A:
[2-291]
----------
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
--------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
T
------
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
--
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
-----
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
-
M
P
DY---
K
---
P
S
F
P
K
W
A
-
R
Q
D
F
-
S
K
V
V
P
P
-
L
------------
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
--------------
76
PsiBlast_CBE
76.21
48%
-119
- C1 -
2WEV
1
CDK2_HUMAN
A:
[2-291]
----------
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
T
------
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
--
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
-----
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
-
M
P
DY---
K
---
P
S
F
P
K
W
A
-
R
Q
D
F
-
S
K
V
V
P
P
-
L
------------
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
----------------
88
PsiBlast_CBE
74.98
48%
-113
- C1 -
2VTN
1
CDK2_HUMAN
A:
[2-291]
----------
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
--------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
T
------
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
--
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
---------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
-
M
P
DY---
K
---
P
S
F
P
K
W
A
-
R
Q
D
F
-
S
K
V
V
P
P
-
L
------------
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
--------------
82
PsiBlast_CBE
74.91
48%
-115
- C1 -
2VU3
1
CDK2_HUMAN
A:
[2-291]
----------
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
---------
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
T
------
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
--
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
----
F
G
V
P
-----
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
-
M
P
DY---
K
---
P
S
F
P
K
W
A
-
R
Q
D
F
-
S
K
V
V
P
P
-
L
------------
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
--------------
132
HHSearch
74.54
49%
-117
- C1 -
3NIZ
1
?
A:
[20-309]
---------
M
E
K
Y
Q
K
L
E
K
V
G
E
G
T
Y
G
V
V
Y
K
A
K
D
--
S
Q
G
R
I
V
A
L
K
R
I
R
------
G
I
P
S
T
A
I
R
E
I
S
L
L
K
E
L
H
---
H
P
N
I
V
S
L
I
D
V
I
H
S
------
E
R
C
L
T
L
V
F
E
F
M
E
K
D
L
K
K
V
L
D
E
N
---
K
T
G
L
Q
D
S
Q
I
K
I
Y
L
Y
Q
L
L
R
G
V
A
H
C
H
Q
H
R
I
L
H
R
D
L
K
P
Q
N
L
L
I
N
S
-
D
G
A
L
K
L
A
D
F
G
L
A
R
A
F
G
I
P
-----
V
R---
H
E
V
V
T
L
W
Y
R
A
P
D
V
L
M
G
S
K
K
-
Y
S
T
S
V
D
I
W
S
I
G
C
I
F
A
E
M
I
T
-----------
G
K
P
L
F
P
G
V
T
-------
D
D
D
Q
L
P
K
I
F
S
I
L
G
T
P
N
P
R
E
W
P
Q
V
Q
E
-
L
P
L
W
K
--
Q
---
R
T
F
Q
V
F
E
-
K
K
P
W
-
S
S
I
I
P
G
-
F
------------
C
Q
E
G
I
D
L
L
S
N
M
L
C
F
D
P
N
K
R
I
S
A
R
D
A
M
N
H
P
Y
F
K
D
L
D
P
Q
I
-------------------
25
PsiBlast_CBE
74.47
48%
-121
- C1 -
5D1J
1
?
A:
[2-291]
----------
E
N
F
Q
K
V
E
K
I
G
E
--
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
--------------
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
T
------
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
--
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
----------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
-
M
P
DY---
K
---
P
S
F
P
K
W
A
-
R
Q
D
F
-
S
K
V
V
P
P
-
L
------------
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
--------------
125
HHSearch
74.16
36%
-106
- C1 -
2B9H
1
FUS3_YEAST
A:
[1-314]
M
P
K
R
I
V
Y
N
I
S
S
D
F
Q
L
K
S
L
L
G
E
G
A
Y
G
V
V
C
S
A
T
H
-
K
P
T
G
E
I
V
A
I
K
K
I
E
P
F
D
-
K
P
L
F
A
L
R
T
L
R
E
I
K
I
L
K
H
F
K
---
H
E
N
I
I
T
I
F
N
I
Q
R
P
D
S
F
-
E
N
F
N
E
V
Y
I
I
Q
E
L
M
Q
T
D
L
H
R
V
I
S
T
Q
-----
M
L
S
D
D
H
I
Q
Y
F
I
Y
Q
T
L
R
A
V
K
V
L
H
G
S
N
V
I
H
R
D
L
K
P
S
N
L
L
I
N
S
-
N
C
D
L
K
V
C
D
F
G
L
A
R
I
I
D
-----------
V
E
F
V
A
T
R
W
Y
R
A
P
E
V
M
L
T
S
A
K
-
Y
S
R
A
M
D
V
W
S
C
G
C
I
L
A
E
L
F
L
-----------
R
R
P
I
F
P
G
R
D
-------
Y
R
H
Q
L
L
L
I
F
G
I
I
G
T
P
H
S
D
N
D
L
R
C
I
E
-
S
P
R
A
R
E
Y
I
---
K
S
L
P
M
Y
P
-
A
A
P
L
-
E
K
M
F
P
R
-
V
------------
N
P
K
G
I
D
L
L
Q
R
M
L
V
F
D
P
A
K
R
I
T
A
K
E
A
L
E
H
P
Y
L
Q
T
Y
H
D
P
N
D
E
P
E
G
E
P
I
P
P
S
F
F
E
F
D
H
Y
K
124
HHSearch
73.98
48%
-114
- C1 -
4AU8
2
CDK5_HUMAN
A:
[5-293]
---------
S
Q
K
Y
E
K
L
E
K
I
G
E
G
T
Y
G
T
V
F
K
A
K
N
-
R
E
T
H
E
I
V
A
L
K
R
V
---------
P
S
S
A
L
R
E
I
C
L
L
K
E
L
K
---
H
K
N
I
V
R
L
H
D
V
L
H
---------
K
L
T
L
V
F
E
F
C
D
Q
D
L
K
K
Y
F
D
S
C
--
N
-
G
D
L
D
P
E
I
V
K
S
F
L
F
Q
L
L
K
G
L
G
F
C
H
S
R
N
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
R
-
N
G
E
L
K
L
A
D
F
G
L
A
R
A
F
G
I
P
-----
V
R--
S
A
E
V
V
T
L
W
Y
R
P
P
D
V
L
F
G
A
-
K
L
Y
S
T
S
I
D
M
W
S
A
G
C
I
F
A
E
L
A
N
A
----------
G
R
P
L
F
P
G
N
D
-------
V
D
D
Q
L
K
R
I
F
R
L
L
G
T
P
T
E
E
Q
W
P
S
M
T
K
-
L
P
-----
D
Y
--
K
P
Y
P
M
Y
P
A
T
T
S
L
-
V
N
V
V
P
K
-
L
------------
N
A
T
G
R
D
L
L
Q
N
L
L
K
C
N
P
V
Q
R
I
S
A
E
E
A
L
Q
H
P
Y
F
S
D
F
-----------------------
115
HHSearch
71.16
37%
-99
- C1 -
3N9X
2
?
A:
[25-370]
---------
P
D
N
Y
I
I
K
H
L
I
G
R
G
S
Y
G
Y
V
Y
L
A
Y
D
-
K
N
T
E
K
N
V
A
I
K
K
V
N
R
M
F
E
D
L
I
D
C
K
R
I
L
R
E
I
T
I
L
N
R
L
K
---
S
D
Y
I
I
R
L
Y
D
L
I
I
P
D
D
L
-
L
K
F
D
E
L
Y
I
V
L
E
I
A
D
S
D
L
K
K
L
F
K
T
P
----
I
F
L
T
E
E
H
I
K
T
I
L
Y
N
L
L
L
G
E
N
F
I
H
E
S
G
I
I
H
R
D
L
K
P
A
N
C
L
L
N
Q
-
D
C
S
V
K
V
C
D
F
G
L
A
R
T
I
--------------
H
V
V
T
R
W
Y
R
A
P
E
L
I
L
L
Q
E
N
-
Y
T
K
S
I
D
I
W
S
T
G
C
I
F
A
E
L
L
N
MLQSHINDPTN
R
F
P
L
F
P
G
S
S
CFPH
E
K
S
N
R
D
Q
L
N
I
I
F
N
I
I
G
T
P
T
E
D
D
L
K
N
I
N
K
-
P
E
V
I
K
Y
-
I
---
K
L
F
P
H
R
K
-
P
I
N
L
-
K
Q
K
Y
P
S
-
I
------------
S
D
D
G
I
N
L
L
E
S
M
L
K
F
N
P
N
K
R
I
T
I
D
Q
A
L
D
H
P
Y
L
K
D
V
R
K
K
K
L
E
T
K
K
I
I
L
P
F
D
D
W
M
V
L
S
E
T
118
HHSearch
67.38
32%
-119
- C1 -
3EB0
3
?
A:
[6-328]
---------
S
K
K
Y
S
L
G
K
T
L
G
T
G
-
F
G
I
V
C
E
V
F
D
I
-
E
S
G
K
R
F
A
L
K
K
V
L
Q
D
P
R
------
Y
K
N
R
E
L
D
I
M
K
V
L
D
---
H
V
N
I
I
K
L
V
D
Y
F
Y
T
T
-----
N
K
Y
L
N
V
I
M
E
Y
V
P
D
T
L
H
K
V
L
K
S
F
I
R
S
G
R
S
I
P
M
N
L
I
S
I
Y
I
Y
Q
L
F
R
A
V
G
F
I
H
S
L
G
I
C
H
R
D
I
K
P
Q
N
L
L
V
N
S
K
D
N
T
L
K
L
C
D
F
G
S
A
K
K
L
I
P
S
-----
E
-
P
S
V
A
Y
I
C
S
R
F
Y
R
A
P
E
L
M
L
G
A
-
T
E
Y
T
P
S
I
D
L
W
S
I
G
C
V
F
G
E
L
I
L
-----------
G
K
P
L
F
S
G
E
T
-------
S
I
D
Q
L
V
R
I
I
Q
I
M
G
T
P
T
K
E
Q
M
I
R
M
N
P
H
Y
----------
V
R
F
P
T
L
K
-
A
K
D
W
-
R
K
I
L
P
E
G
T
------------
P
S
L
A
I
D
L
L
E
Q
I
L
R
Y
E
P
D
L
R
I
N
P
Y
E
A
M
A
H
P
F
F
D
H
L
R
N
S
I
P
Q
L
F
N
F
S
P
Y
E
L
S
I
I
P
G
N
V
L
119
HHSearch
66.67
35%
-106
- C1 -
4IC7
1
MK07_HUMAN
A:
[54-352]
---------
G
D
E
Y
E
I
I
E
T
I
G
N
G
A
Y
G
V
V
S
S
A
R
R
-
R
L
T
G
Q
Q
V
A
I
K
K
I
P
N
A
F
D
V
V
T
N
A
K
R
T
L
R
E
L
K
I
L
K
H
F
K
---
H
D
N
I
I
A
I
K
D
I
L
R
P
T
V
P
Y
G
E
F
K
S
V
Y
V
V
L
D
L
M
E
S
D
L
H
Q
I
I
H
S
S
----
Q
P
L
T
L
E
H
V
R
Y
F
L
Y
Q
L
L
R
G
L
K
Y
M
H
S
A
Q
V
I
H
R
D
L
K
P
S
N
L
L
V
N
E
-
N
C
E
L
K
I
G
D
F
G
M
A
R
G
L
C
T
S
PAEHQ
Y
-
F
M
T
E
Y
V
A
T
R
W
Y
R
A
P
E
L
M
L
S
L
H
E
-
Y
T
Q
A
I
D
L
W
S
V
G
C
I
F
G
E
M
L
A
-----------
R
R
Q
L
F
P
G
K
N
-------
Y
V
H
Q
L
Q
L
I
M
M
V
L
G
T
P
S
P
A
V
I
Q
A
V
G
A
-
E
R
VRAY-
I
---
Q
S
L
P
P
R
Q
-
P
V
P
W
-
E
T
V
Y
P
G
-
A
------------
D
R
Q
A
L
S
L
L
G
R
M
L
R
F
E
P
S
A
R
I
S
A
A
A
A
L
R
H
P
F
L
A
K
Y
H
D
P
D
D
E
P
D
C
A
P
P
F
D
F
A
F
D
R
E
A
L
T
116
HHSearch
65.70
38%
-100
- C1 -
1UA2
1
CDK7_HUMAN
A:
[13-299]
-------------
E
K
L
D
F
L
G
E
G
Q
F
A
T
V
Y
K
A
R
D
-
K
N
T
N
Q
I
V
A
I
K
K
I
---------
N
R
T
A
L
R
E
I
K
L
L
Q
E
L
S
---
H
P
N
I
I
G
L
L
D
A
F
G
H
------
K
S
N
I
S
L
V
F
D
F
M
E
T
D
L
E
V
I
I
K
D
N
---
S
L
V
L
T
P
S
H
I
K
A
Y
M
L
M
T
L
Q
G
L
E
Y
L
H
Q
H
W
I
L
H
R
D
L
K
P
N
N
L
L
L
D
E
-
N
G
V
L
K
L
A
D
F
G
L
A
K
S
F
G
S
P
-----
N
R
A
Y
T
H
Q
V
V
T
R
W
Y
R
A
P
E
L
L
F
G
A
-
R
M
Y
G
V
G
V
D
M
W
A
V
G
C
I
L
A
E
L
L
L
-----------
R
V
P
F
L
P
G
D
S
-------
D
L
D
Q
L
T
R
I
F
E
T
L
G
T
P
T
E
E
Q
W
P
D
M
C
S
-
L
P
D
----
Y
---
V
T
F
K
S
F
P
-
G
I
P
L
-
H
H
I
F
S
A
-
A
------------
G
D
D
L
L
D
L
I
Q
G
L
F
L
F
N
P
C
A
R
I
T
A
T
Q
A
L
K
M
K
Y
F
S
N
R
P
G
P
T
P
G
C
Q
L
P
R
P
N
----------
133
HHSearch
65.49
36%
-105
- C1 -
4BGQ
3
CDKL5_HUMAN
A:
[10-301]
--------
V
M
N
K
F
E
I
L
G
V
V
G
E
G
A
Y
G
V
V
L
K
C
R
H
-
K
E
T
H
E
I
V
A
I
K
K
F
K
-------
V
K
E
T
T
L
R
E
L
K
M
L
R
T
L
K
---
Q
E
N
I
V
E
L
K
E
A
F
R
R
------
R
G
K
L
Y
L
V
F
E
Y
V
E
K
N
M
L
E
L
L
E
E
M
--
P
-
N
G
V
P
P
E
K
V
K
S
Y
I
Y
Q
L
I
K
A
I
H
W
C
H
K
N
D
I
V
H
R
D
I
K
P
E
N
L
L
I
S
H
-
N
D
V
L
K
L
C
D
F
G
F
A
R
N
L
S
E
---------------
T
R
W
Y
R
S
P
E
L
L
L
G
A
-
P
-
Y
G
K
S
V
D
M
W
S
V
G
C
I
L
G
E
L
S
D
-----------
G
Q
P
L
F
P
G
E
S
-------
E
I
D
Q
L
F
T
I
Q
K
V
L
G
P
L
P
S
E
Q
M
K
L
F
Y
S
-
N
P
-----
R
FHG
L
R
F
P
A
V
N
H
P
Q
S
L
E
R
R
Y
L
G
I
-
L
------------
N
S
V
L
L
D
L
M
K
N
L
L
K
L
D
P
A
D
R
Y
L
T
E
Q
C
L
N
H
P
T
F
Q
T
Q
R
L
---------------------
127
HHSearch
60.61
35%
-95
- C1 -
3TTJ
1
MK10_HUMAN
A:
[60-361]
--------
V
L
K
R
Y
Q
N
L
K
P
I
G
S
G
A
Q
G
I
V
C
A
A
Y
D
-
A
V
L
D
R
N
V
A
I
K
K
L
S
R
P
F
Q
N
Q
T
H
A
K
R
A
Y
R
E
L
V
L
M
K
C
V
N
---
H
K
N
I
I
S
L
L
N
V
F
T
P
Q
K
T
L
E
E
F
Q
D
V
Y
L
V
M
E
L
M
D
A
N
L
C
Q
V
I
Q
M
------
E
L
D
H
E
R
M
S
Y
L
L
Y
Q
M
L
C
G
I
K
H
L
H
S
A
G
I
I
H
R
D
L
K
P
S
N
I
V
V
K
S
-
D
C
T
L
K
I
L
D
F
G
L
A
-----
S
-----
F
-
M
M
----
V
T
R
Y
Y
R
A
P
E
V
I
L
G
M
-
G
-
Y
K
E
N
V
D
I
W
S
V
G
C
I
M
G
E
M
V
R
-----------
H
K
I
L
F
P
G
R
D
-------
Y
I
D
Q
W
N
K
V
I
E
Q
L
G
T
P
C
P
E
F
M
K
K
L
Q
P
-
T
V
R
N
Y
--
V
---
E
N
R
P
K
Y
A
-
G
L
T
F
-
P
K
L
F
P
D
-
S
LFPADS
E
H
N
K
L
K
A
S
Q
A
R
D
L
L
S
K
M
L
V
I
D
P
A
K
R
I
S
V
D
D
A
L
Q
H
P
Y
I
N
V
W
Y
D
P
A
E
V
E
A
P
P
E
H
T
I
E
E
W
K
E
L
I
Y
K
128
HHSearch
60.04
35%
-106
- C1 -
2FST
3
MK14_HUMAN
X:
[28-318]
---------
P
E
R
Y
Q
N
L
S
P
V
G
----
G
S
V
C
A
A
F
D
-
T
K
T
G
L
R
V
A
V
K
K
L
S
R
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
---
H
E
N
V
I
G
L
L
D
V
F
T
P
A
R
S
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
----------
Q
K
L
T
D
D
H
V
Q
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
E
-
D
C
E
L
K
I
L
D
-----------------------
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
-
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
-----------
G
R
T
L
F
P
G
T
D
-------
H
I
D
Q
L
K
L
I
L
R
L
V
G
T
P
G
A
E
L
L
K
K
I
S
S
-
E
S
ARNY-
I
---
Q
S
L
T
Q
M
P
-
K
M
N
F
-
A
N
V
F
I
G
-
A
------------
N
P
L
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
P
V
A
D
P
Y
D
Q
S
L
E
S
R
D
L
L
I
78
PsiBlast_CBE
45.10
48%
3
- C1 -
2W17
1
CDK2_HUMAN
A:
[5-292]
----------
E
N
F
Q
K
V
E
K
I
G
E
-
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-----
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
T
------
E
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
--
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
-
M
P
DY---
K
---
P
S
F
P
K
W
A
-
R
Q
D
F
-
S
K
V
V
P
P
-
L
------------
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
--------------
61
PsiBlast_CBE
44.65
48%
3
- C1 -
3IGG
1
CDK2_HUMAN
A:
[5-292]
----------
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
--------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
T
------
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
--
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
-----
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
-
M
P
DY---
K
---
P
S
F
P
K
W
A
-
R
Q
D
F
-
S
K
V
V
P
P
-
L
------------
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
--------------
36
PsiBlast_CBE
43.82
48%
-0
- C1 -
4FKO
1
CDK2_HUMAN
A:
[5-292]
----------
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
T
------
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
--
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
-----
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
-
M
P
DY---
K
---
P
S
F
P
K
W
A
-
R
Q
D
F
-
S
K
V
V
P
P
-
L
------------
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
--------------
54
PsiBlast_CBE
43.74
48%
2
- C1 -
3SW7
1
CDK2_HUMAN
A:
[5-292]
----------
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
T
------
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
--
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
-
M
P
DY---
K
---
P
S
F
P
K
W
A
-
R
Q
D
F
-
S
K
V
V
P
P
-
L
------------
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
--------------
42
PsiBlast_CBE
43.64
48%
3
- C1 -
4EK5
1
CDK2_HUMAN
A:
[5-292]
----------
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
---------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
T
------
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
--
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
-----
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
-
M
P
DY---
K
---
P
S
F
P
K
W
A
-
R
Q
D
F
-
S
K
V
V
P
P
-
L
------------
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
--------------
114
HHSearch
43.56
50%
7
- C1 -
4EK4
1
CDK2_HUMAN
A:
[4-295]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
---------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
T
------
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
--
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
-----
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
-
M
P
DY---
K
---
P
S
F
P
K
W
A
-
R
Q
D
F
-
S
K
V
V
P
P
-
L
------------
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
----------------
81
PsiBlast_CBE
43.56
48%
3
- C1 -
2VV9
1
CDK2_HUMAN
A:
[5-292]
----------
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
T
------
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
--
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
-
M
P
DY---
K
---
P
S
F
P
K
W
A
-
R
Q
D
F
-
S
K
V
V
P
P
-
L
------------
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
--------------
43
PsiBlast_CBE
42.93
48%
6
- C1 -
4EK4
1
CDK2_HUMAN
A:
[5-292]
----------
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
---------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
T
------
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
--
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
-----
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
-
M
P
DY---
K
---
P
S
F
P
K
W
A
-
R
Q
D
F
-
S
K
V
V
P
P
-
L
------------
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
----------------
34
PsiBlast_CBE
42.92
48%
1
- C1 -
4FKQ
2
CDK2_HUMAN
A:
[5-292]
----------
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
T
------
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
--
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
--------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
-
M
P
DY---
K
---
P
S
F
P
K
W
A
-
R
Q
D
F
-
S
K
V
V
P
P
-
L
------------
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
--------------
32
PsiBlast_CBE
42.81
48%
2
- C1 -
4FKV
2
CDK2_HUMAN
A:
[5-292]
----------
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-----
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
T
------
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
--
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
----------------
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
-
M
P
DY---
K
---
P
S
F
P
K
W
A
-
R
Q
D
F
-
S
K
V
V
P
P
-
L
------------
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
--------------
38
PsiBlast_CBE
42.65
48%
3
- C1 -
4FKJ
1
CDK2_HUMAN
A:
[5-292]
----------
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
---------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
T
------
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
--
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
----------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
-
M
P
DY---
K
---
P
S
F
P
K
W
A
-
R
Q
D
F
-
S
K
V
V
P
P
-
L
------------
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
--------------
41
PsiBlast_CBE
42.58
48%
2
- C1 -
4EK6
1
CDK2_HUMAN
A:
[5-292]
----------
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
----------
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
T
------
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
--
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
---------------
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
-
M
P
DY---
K
---
P
S
F
P
K
W
A
-
R
Q
D
F
-
S
K
V
V
P
P
-
L
------------
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
--------------
31
PsiBlast_CBE
42.55
48%
4
- C1 -
4FKW
2
CDK2_HUMAN
A:
[5-292]
----------
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-----
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
T
------
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
--
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
-
M
P
DY---
K
---
P
S
F
P
K
W
A
-
R
Q
D
F
-
S
K
V
V
P
P
-
L
------------
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
--------------
39
PsiBlast_CBE
42.45
48%
7
- C1 -
4FKG
1
CDK2_HUMAN
A:
[5-292]
----------
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
---------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
T
------
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
--
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
--------R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
-
M
P
DY---
K
---
P
S
F
P
K
W
A
-
R
Q
D
F
-
S
K
V
V
P
P
-
L
------------
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
--------------
62
PsiBlast_CBE
42.31
48%
4
- C1 -
3IG7
1
CDK2_HUMAN
A:
[5-292]
----------
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
--------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
T
------
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
--
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
-----------------
T
L
W
Y
R
A
P
E
I
L
L
G
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
-
M
P
DY---
K
---
P
S
F
P
K
W
A
-
R
Q
D
F
-
S
K
V
V
P
P
-
L
------------
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
--------------
33
PsiBlast_CBE
42.17
48%
4
- C1 -
4FKR
2
CDK2_HUMAN
A:
[5-292]
----------
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
T
------
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
--
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
--------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
-
M
P
DY---
K
---
P
S
F
P
K
W
A
-
R
Q
D
F
-
S
K
V
V
P
P
-
L
------------
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
--------------