@TOME V2.3
(Nov 2016)

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Alignment:

3D Common Core:

Structural Clustering:

Modeller Result :

Complexes Modeling
Templates Information:
Sequence & Result Tab:

Values color: [ Good | Correct | Middling | Bad ]Sequence color : MutatedHelixStrandConserved

Query sequence : CDK8_HUMAN: (2015-10-05 )
MDYDFKVKLSSERERVEDLFEYEGCKVGRGTYGHVYKAKRKDGKDDKDYALKQIEGTGISMSACREIALLRELKHPNVISLQKVFLSHADRKVWLLFDYAEHDLWHIIKFHRASKANKKPVQLPRGMVKSLLYQILDGIHYLHANWVLHRDLKPANILVMGEGPERGRVKIADMGFARLFNSPLKPLADLDPVVVTFWYRAPELLLGARHYTKAIDIWAIGCIFAELLTSEPIFHCRQEDIKTSNPYHHDQLDRIFNVMGFPADKDWEDIKKMPEHSTLMKDFRRNTYTNCSLIKYMEKHKVKPDSKAFHLLQKLLTMDPIKRITSEQAMQDPYFLEDPLPTSDVFAGCQIPYPKREFLTEEEPDDKGDKKNQQQQQGNNHTNGTGHPGNQDSSHTQGPPLKKVRVVPPTTTSGGLIMTSDYQRSNPHAAYPNPGPSTSQPQSSMGYSATSQQPPQYSHQTHRY

Atome Classification :

(104 SA) .........10........20........30........40........50...----.....----60........70........80........90---.........100.......110.......120-.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......-230.......240.......250.......260.......270.......280.....--..290........300..--.....310.......320.......330...--....340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460..
(Atome) (Ident) (Tito) (Num) (Ligand) (Uniprot) MDYDFKVKLSSERERVEDLFEYEGCKVGRGTYGHVYKAKRKDGKDDKDYALKQI----EGTGI----SMSACREIALLRELKHPNVISLQKVFLSHAD----RKVWLLFDYAEHDLWHIIKFHRASKANKKPVQ-LPRGMVKSLLYQILDGIHYLHANWVLHRDLKPANILVMGEGPERGRVKIADMGFARLFNSPLKPLADLDPVVVTFWYRAPELLLGARHYTKAIDIWAIGCIFAELLT-SEPIFHCRQEDIKTSNPYHHDQLDRIFNVMGFPADKDWEDIKKMPEHSTLMKDFRRNT--YTN-CSLIKYMEKHKVKP--DSKAFHLLQKLLTMDPIKRITSEQAMQDPYF--LEDPLPTSDVFAGCQIPYPKREFLTEEEPDDKGDKKNQQQQQGNNHTNGTGHPGNQDSSHTQGPPLKKVRVVPPTTTSGGLIMTSDYQRSNPHAAYPNPGPSTSQPQSSMGYSATSQQPPQYSHQTHRY
2 PsiBlast_PDB 95.35100%-126 - C1 -4F6S CDK8_HUMAN A:[3-361] MDYDFKVKLSSERERVEDLFEYEGCKVGRGTYGHVYKAKRKDGKDDKDYALKQI----EGTGI----SMSACREIALLRELKHPNVISLQKVFLSHAD----RKVWLLFDYAEHDLWHIIKFHRAS---------LPRGMVKSLLYQILDGIHYLHANWVLHRDLKPANILVMGEGPERGRVKIADMGFA-----------------VTFWYRAPELLLGARHYTKAIDIWAIGCIFAELLT-SEPIFHCR-------NPYHHDQLDRIFNVMGFPADKDWEDIKKMPEHSTLMKDFRRNT--YTN-CSLIKYMEKHKVKP--DSKAFHLLQKLLTMDPIKRITSEQAMQDPYF--LEDPLPTSDVFAGCQIPYPKREFL---------------------------------------------------------------------------------------------------------
4 PsiBlast_PDB 94.98100%-122 - C1 -4F6W CDK8_HUMAN A:[3-361] MDYDFKVKLSSERERVEDLFEYEGCKVGRGTYGHVYKAKRKDGKDDKDYALKQI----EGTGI----SMSACREIALLRELKHPNVISLQKVFLSHAD----RKVWLLFDYAEHDLWHIIKFHRASK-----VQ-LPRGMVKSLLYQILDGIHYLHANWVLHRDLKPANILVMGEGPERGRVKIADMGFA------------------TFWYRAPELLLGARHYTKAIDIWAIGCIFAELLT-SEPIFHCRQ------NPYHHDQLDRIFNVMGFPADKDWEDIKKMPEHSTLMKDFRRNT--YTN-CSLIKYMEKHKVKP--DSKAFHLLQKLLTMDPIKRITSEQAMQDPYF--LEDPLPTSDVFAGCQIPYPKREFL---------------------------------------------------------------------------------------------------------
8 PsiBlast_PDB 94.89100%-127 - C1 -4F7N CDK8_HUMAN A:[3-363] MDYDFKVKLSSERERVEDLFEYEGCKVGRGTYGHVYKAKRKDGKDDKDYALKQI----EGTGI----SMSACREIALLRELKHPNVISLQKVFLSHAD----RKVWLLFDYAEHDLWHIIKFHRAS------VQ-LPRGMVKSLLYQILDGIHYLHANWVLHRDLKPANILVMGEGPERGRVKIADMGF-----------------VVTFWYRAPELLLGARHYTKAIDIWAIGCIFAELLT-SEPIFHCRQE-----NPYHHDQLDRIFNVMGFPADKDWEDIKKMPEHSTLMKDFRRNT--YTN-CSLIKYMEKHKVKP--DSKAFHLLQKLLTMDPIKRITSEQAMQDPYF--LEDPLPTSDVFAGCQIPYPKREFLTE-------------------------------------------------------------------------------------------------------
5 PsiBlast_PDB 94.71100%-128 - C1 -4F70 CDK8_HUMAN A:[3-361] MDYDFKVKLSSERERVEDLFEYEGCKVGRGTYGHVYKAKRKDGKDDKDYALKQI----EGTGI----SMSACREIALLRELKHPNVISLQKVFLSHAD----RKVWLLFDYAEHDLWHIIKFHRASKA-------LPRGMVKSLLYQILDGIHYLHANWVLHRDLKPANILVMGEGPERGRVKIADM--------------------VTFWYRAPELLLGARHYTKAIDIWAIGCIFAELLT-SEPIFHCR-------NPYHHDQLDRIFNVMGFPADKDWEDIKKMPEHSTLMKDFRRNT--YTN-CSLIKYMEKHKVKP--DSKAFHLLQKLLTMDPIKRITSEQAMQDPYF--LEDPLPTSDVFAGCQIPYPKREFL---------------------------------------------------------------------------------------------------------
110 HHSearch 94.36100%-123 - C1 -4F6U CDK8_HUMAN A:[3-361] MDYDFKVKLSSERERVEDLFEYEGCKVGRGTYGHVYKAKRKDGKDDKDYALKQI----EGTGI----SMSACREIALLRELKHPNVISLQKVFLSHAD----RKVWLLFDYAEHDLWHIIKFHRASK-----VQ-LPRGMVKSLLYQILDGIHYLHANWVLHRDLKPANILVMGEGPERGRVKIADMGF-----------------VVTFWYRAPELLLGARHYTKAIDIWAIGCIFAELLT-SEPIFHCRQE-----NPYHHDQLDRIFNVMGFPADKDWEDIKKMPEHSTLMKDFRRNT--YTN-CSLIKYMEKHKVKP--DSKAFHLLQKLLTMDPIKRITSEQAMQDPYF--LEDPLPTSDVFAGCQIPYPKREFL---------------------------------------------------------------------------------------------------------
3 PsiBlast_PDB 94.36100%-123 - C1 -4F6U CDK8_HUMAN A:[3-361] MDYDFKVKLSSERERVEDLFEYEGCKVGRGTYGHVYKAKRKDGKDDKDYALKQI----EGTGI----SMSACREIALLRELKHPNVISLQKVFLSHAD----RKVWLLFDYAEHDLWHIIKFHRASK-----VQ-LPRGMVKSLLYQILDGIHYLHANWVLHRDLKPANILVMGEGPERGRVKIADMGF-----------------VVTFWYRAPELLLGARHYTKAIDIWAIGCIFAELLT-SEPIFHCRQE-----NPYHHDQLDRIFNVMGFPADKDWEDIKKMPEHSTLMKDFRRNT--YTN-CSLIKYMEKHKVKP--DSKAFHLLQKLLTMDPIKRITSEQAMQDPYF--LEDPLPTSDVFAGCQIPYPKREFL---------------------------------------------------------------------------------------------------------
9 PsiBlast_PDB 93.97100%-124 - C1 -4F7S CDK8_HUMAN A:[3-361] MDYDFKVKLSSERERVEDLFEYEGCKVGRGTYGHVYKAKRKDGKDDKDYALKQI----EGTGI----SMSACREIALLRELKHPNVISLQKVFLSHAD----RKVWLLFDYAEHDLWHIIKFHRASK------Q-LPRGMVKSLLYQILDGIHYLHANWVLHRDLKPANILVMGEGPERGRVKIADMGFARLFNSPLKP---------TFWYRAPELLLGARHYTKAIDIWAIGCIFAELLT-SEPIFHCR-----TSNPYHHDQLDRIFNVMGFPADKDWEDIKKMPEHSTLMKDFRRNT--YTN-CSLIKYMEKHKVKP--DSKAFHLLQKLLTMDPIKRITSEQAMQDPYF--LEDPLPTSDVFAGCQIPYPKREFL---------------------------------------------------------------------------------------------------------
6 PsiBlast_PDB 93.06100%-126 - C1 -4F7J CDK8_HUMAN A:[3-361] MDYDFKVKLSSERERVEDLFEYEGCKVGRGTYGHVYKAKRKDGKDDKDYALKQI----EGTGI----SMSACREIALLRELKHPNVISLQKVFLSHAD----RKVWLLFDYAEHDLWHIIKFHR---------Q-LPRGMVKSLLYQILDGIHYLHANWVLHRDLKPANILVMGEGPERGRVKIADMGF------------------VTFWYRAPELLLGARHYTKAIDIWAIGCIFAELLT-SEPIFHCRQ------NPYHHDQLDRIFNVMGFPADKDWEDIKKMPEHSTLMKDFRRNT--YTN-CSLIKYMEKHKVKP--DSKAFHLLQKLLTMDPIKRITSEQAMQDPYF--LEDPLPTSDVFAGCQIPYPKREFL---------------------------------------------------------------------------------------------------------
7 PsiBlast_PDB 92.68100%-124 - C1 -4F7L CDK8_HUMAN A:[3-361] MDYDFKVKLSSERERVEDLFEYEGCKVGRGTYGHVYKAKRKDGKDDKDYALKQI----EGTGI----SMSACREIALLRELKHPNVISLQKVFLSHAD----RKVWLLFDYAEHDLWHIIKFHRAS-------Q-LPRGMVKSLLYQILDGIHYLHANWVLHRDLKPANILVMGEGPERGRVKIADMG--------------------TFWYRAPELLLGARHYTKAIDIWAIGCIFAELLT-SEPIFHCRQ------NPYHHDQLDRIFNVMGFPADKDWEDIKKMPEHSTLMKDFRRNT--YTN-CSLIKYMEKHKVKP--DSKAFHLLQKLLTMDPIKRITSEQAMQDPYF--LEDPLPTSDVFAGCQIPYPKREFL---------------------------------------------------------------------------------------------------------
1 PsiBlast_PDB 92.16100%-132 - C1 -3RGF CDK8_HUMAN A:[3-355] MDYDFKVKLSSERERVEDLFEYEGCKVG-----HVYKAKRKDGKDDKDYALKQI----EGTGI----SMSACREIALLRELKHPNVISLQKVFLSHAD----RKVWLLFDYAEHDLWHIIKFHRASK--------LPRGMVKSLLYQILDGIHYLHANWVLHRDLKPANILVMGEGPERGRVKIADMGFAR----------------VTFWYRAPELLLGARHYTKAIDIWAIGCIFAELLT-SEPIFHCRQ------NPYHHDQLDRIFNVMGFPADKDWEDIKKMPEHSTLMKDFRRNT--YTN-CSLIKYMEKHKVKP--DSKAFHLLQKLLTMDPIKRITSEQAMQDPYF--LEDPLPTSDVFAGCQIPY---------------------------------------------------------------------------------------------------------------
27 PsiBlast_CBE 66.2738%-108 - C1 -3S00 CDK2_HUMAN A:[17-302] -------------------------KIGEGTYGVVYKARNK--LTGEVVALKKIR----TEGV----PSTAIREISLLKELNHPNIVKLLDVI--HTE----NKLYLVFEFLHQDL---KKFMDASALTGIPLP-L----IKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGA----IKLADFGLARAFGVPVRTYTH---EVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVT-RRALFPGDSEI---------DQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQD--FS------------KVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL-----------------------------------------------------------------------------------------------------------------------
65 PsiBlast_CBE 66.2038%-108 - C1 -3R6X CDK2_HUMAN A:[17-302] -------------------------KIGEGTYGVVYKARNK--LTGEVVALKKIR----TEGV----PSTAIREISLLKELNHPNIVKLLDVI--HTE----NKLYLVFEFLHQDL---KKFMDASALTGIPLP-L----IKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGA----IKLADFGLARAFGVPVRTYTH---EVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVT-RRALFPGDSEI---------DQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQD--FS------------KVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL-----------------------------------------------------------------------------------------------------------------------
68 PsiBlast_CBE 66.0638%-107 - C1 -3R1S CDK2_HUMAN A:[17-302] -------------------------KIGEGTYGVVYKARNK--LTGEVVALKKIR----TEGV----PSTAIREISLLKELNHPNIVKLLDVI--HTE----NKLYLVFEFLHQDL---KKFMDASALTGIPLP-L----IKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGA----IKLADFGLARAFGVPVRTYTH---EVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVT-RRALFPGDSEI---------DQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQD--FS------------KVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL-----------------------------------------------------------------------------------------------------------------------
57 PsiBlast_CBE 65.6238%-108 - C1 -3R83 CDK2_HUMAN A:[17-302] -------------------------KIGEGTYGVVYKARNK--LTGEVVALKKIR----TEGV----PSTAIREISLLKELNHPNIVKLLDVI--HTE----NKLYLVFEFLHQDL---KKFMDASALTGIPLP-L----IKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGA----IKLADFGLARAFGVPVRTYTH---EVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVT-RRALFPGDSEI---------DQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQD--FS------------KVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL-----------------------------------------------------------------------------------------------------------------------
67 PsiBlast_CBE 65.4038%-105 - C1 -3R1Y CDK2_HUMAN A:[17-302] -------------------------KIGEGTYGVVYKARNK--LTGEVVALKKIR----TEGV----PSTAIREISLLKELNHPNIVKLLDVI--HTE----NKLYLVFEFLHQDL---KKFMDASALTGIPLP-L----IKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGA----IKLADFGLARAFGVPVRTYTH---EVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVT-RRALFPGDSEI---------DQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQD--FS------------KVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL-----------------------------------------------------------------------------------------------------------------------
52 PsiBlast_CBE 65.3738%-106 - C1 -3R8V CDK2_HUMAN A:[17-302] -------------------------KIGEGTYGVVYKARNK--LTGEVVALKKIR----TEGV----PSTAIREISLLKELNHPNIVKLLDVI--HTE----NKLYLVFEFLHQDL---KKFMDASALTGIPLP-L----IKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGA----IKLADFGLARAFGVPVRTYTH---EVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVT-RRALFPGDSEI---------DQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQD--FS------------KVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL-----------------------------------------------------------------------------------------------------------------------
53 PsiBlast_CBE 65.3438%-103 - C1 -3R8U CDK2_HUMAN A:[17-302] -------------------------KIGEGTYGVVYKARNK--LTGEVVALKKIR----TEGV----PSTAIREISLLKELNHPNIVKLLDVI--HTE----NKLYLVFEFLHQDL---KKFMDASALTGIPLP-L----IKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGA----IKLADFGLARAFGVPVRTYTH---EVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVT-RRALFPGDSEI---------DQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQD--FS------------KVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL-----------------------------------------------------------------------------------------------------------------------
71 PsiBlast_CBE 65.2938%-107 - C1 -3QZH CDK2_HUMAN A:[17-302] -------------------------KIGEGTYGVVYKARNK--LTGEVVALKKIR----TEGV----PSTAIREISLLKELNHPNIVKLLDVI--HTE----NKLYLVFEFLHQDL---KKFMDASALTGIPLP-L----IKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGA----IKLADFGLARAFGVPVRTYTH---EVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVT-RRALFPGDSEI---------DQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQD--FS------------KVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL-----------------------------------------------------------------------------------------------------------------------
66 PsiBlast_CBE 65.1238%-104 - C1 -3R28 CDK2_HUMAN A:[17-302] -------------------------KIGEGTYGVVYKARNK--LTGEVVALKKIR----TEGV----PSTAIREISLLKELNHPNIVKLLDVI--HTE----NKLYLVFEFLHQDL---KKFMDASALTGIPLP-L----IKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGA----IKLADFGLARAFGVPVRTYTH---EVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVT-RRALFPGDSEI---------DQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQD--FS------------KVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL-----------------------------------------------------------------------------------------------------------------------
45 PsiBlast_CBE 65.0938%-107 - C1 -3RAI CDK2_HUMAN A:[17-302] -------------------------KIGEGTYGVVYKARNK--LTGEVVALKKIR----TEGV----PSTAIREISLLKELNHPNIVKLLDVI--HTE----NKLYLVFEFLHQDL---KKFMDASALTGIPLP-L----IKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGA----IKLADFGLARAFGVPVRTYTH---EVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVT-RRALFPGDSEI---------DQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQD--FS------------KVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL-----------------------------------------------------------------------------------------------------------------------
20 PsiBlast_PDB 65.0738%-107 - C1 -3QQF CDK2_HUMAN A:[17-302] -------------------------KIGEGTYGVVYKARNK--LTGEVVALKKIR----TEGV----PSTAIREISLLKELNHPNIVKLLDVI--HTE----NKLYLVFEFLHQDL---KKFMDASALTGIPLP-L----IKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGA----IKLADFGLARAFGVPVRTYTH---EVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVT-RRALFPGDSEI---------DQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQD--FS------------KVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL-----------------------------------------------------------------------------------------------------------------------
63 PsiBlast_CBE 65.0438%-108 - C1 -3R73 CDK2_HUMAN A:[17-302] -------------------------KIGEGTYGVVYKARNK--LTGEVVALKKIR----TEGV----PSTAIREISLLKELNHPNIVKLLDVI--HTE----NKLYLVFEFLHQDL---KKFMDASALTGIPLP-L----IKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGA----IKLADFGLARAFGVPVRTYTH---EVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVT-RRALFPGDSEI---------DQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQD--FS------------KVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL-----------------------------------------------------------------------------------------------------------------------
92 PsiBlast_CBE 65.0038%-103 - C1 -3QQJ CDK2_HUMAN A:[17-302] -------------------------KIGEGTYGVVYKARNK--LTGEVVALKKIR----TEGV----PSTAIREISLLKELNHPNIVKLLDVI--HTE----NKLYLVFEFLHQDL---KKFMDASALTGIPLP-L----IKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGA----IKLADFGLARAFGVPVRTYTH---EVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVT-RRALFPGDSEI---------DQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQD--FS------------KVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL-----------------------------------------------------------------------------------------------------------------------
33 PsiBlast_CBE 64.9538%-107 - C1 -3ROY CDK2_HUMAN A:[17-302] -------------------------KIGEGTYGVVYKARNK--LTGEVVALKKIR----TEGV----PSTAIREISLLKELNHPNIVKLLDVI--HTE----NKLYLVFEFLHQDL---KKFMDASALTGIPLP-L----IKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGA----IKLADFGLARAFGVPVRTYTH---EVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVT-RRALFPGDSEI---------DQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQD--FS------------KVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL-----------------------------------------------------------------------------------------------------------------------
36 PsiBlast_CBE 64.8338%-107 - C1 -3RM7 CDK2_HUMAN A:[17-302] -------------------------KIGEGTYGVVYKARNK--LTGEVVALKKIR----TEGV----PSTAIREISLLKELNHPNIVKLLDVI--HTE----NKLYLVFEFLHQDL---KKFMDASALTGIPLP-L----IKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGA----IKLADFGLARAFGVPVRTYTH---EVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVT-RRALFPGDSEI---------DQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQD--FS------------KVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL-----------------------------------------------------------------------------------------------------------------------