@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : CDKL1_HUMAN: (2015-10-05 )
MEKYEKIGKIGEGSYGVVFKCRNRDTGQIVAIKKFLESEDDPVIKKIALREIRMLKQLKHPNLVNLLEVFRRKRRLHLVFEYCDHTVLHELDRYQRGVPEHLVKSITWQTLQAVNFCHKHNCIHRDVKPENILITKHSVIKLCDFGFARLLAGPSDYYTDYVATRWYRSPELLVGDTQYGPPVDVWAIGCVFAELLSGVPLWPGKSDVDQLYLIRKTLGDLIPRHQQVFSTNQYFSGVKIPDPEDMEPLELKFPNISYPALGLLKGCLHMDPTQRLTCEQLLHHPYFENIREIEDLAKEHNKPTRKTLRKSRKHHCFTETSKLQYLPQLTGSSILPALDNKKYYCDTKKLNYRFPNI
Atome Classification :
(101 SA)
.........10........20...-.....30......-..40........50........60........-----70------..-----......80........90.---...-....100.......110.......120.......130.....-..140.......150-.......160.......170.......180.......190.....-..200.......210.......----------220....-..-.230-.---........240.......250..-..-...260.......270.......280.......290.......300.......310.......320.......330.......340.......350.....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
E
K
Y
E
K
IGKIGEG
S
Y
G
V
V
F
K
CRNR-DTG
Q
I
V
A
I
K
K
F
L
E-SED
D
P
V
I
K
K
I
A
L
R
E
I
R
M
L
K
Q
LKHP
N
L
V
N
L
L
E
V
-----
F
R
------RK-----
R
R
L
H
L
V
F
E
YC
D
H
T
V
L
H
E
L
D
---
R
Y
Q-RG
V
P
E
H
L
V
K
S
I
T
W
Q
T
L
Q
A
V
N
F
C
H
KHNCIHRDVKPE
N
I
L
I
T
K
H
-
S
V
I
K
L
C
D
F
G
F
A
R
L
LA-GP
S
D
Y
Y
T
D
Y
V
A
T
R
WYRSPE
L
L
V
GDTQYGPP
V
D
V
W
A
I
G
C
V
F
A
E
L
LS-GVPLWPGKS
D
V
D
Q
L
Y
L
I
R
K
T
L
G
----------
D
L
I
P
R
H
Q
-
Q
V
-FS---T---NQYFSGVKIPDPEDMEP
L
E
L
KFP-NI-SY
P
A
L
G
L
L
K
G
C
LHMDPTQRL
T
C
E
Q
L
LH
H
P
Y
F
E
N
I
R
E
I
E
D
L
A
K
E
HNK
P
T
R
K
T
L
R
K
SRKHHCFTET
S
K
L
Q
Y
L
P
Q
LTGSSILPALDNK
K
Y
Y
CDTKKLNYRFPNI
21
PsiBlast_CBE
97.88
98%
-133
- C1 -
4AGU
1
CDKL1_HUMAN
C:
[3-292]
-
E
K
Y
E
K
I
G
K
I
G
E
G
S
Y
G
V
V
F
K
C
R
N
R
-
D
T
G
Q
I
V
A
I
K
K
F
L
E
-
S
E
D
D
P
V
I
K
K
I
A
L
R
E
I
R
M
L
K
Q
L
K
H
P
N
L
V
N
L
L
E
V
-----
F
R
------
R
K
-----
R
R
L
H
L
V
F
E
Y
C
D
H
T
V
L
H
E
L
D
---
R
Y
Q
-
R
G
V
P
E
H
L
V
K
S
I
T
W
Q
T
L
Q
A
V
N
F
C
H
K
H
N
C
I
H
R
D
V
K
P
E
N
I
L
I
T
K
H
-
S
V
I
K
L
C
D
F
G
F
A
R
L
L
T
-------------
R
W
Y
R
S
P
E
L
L
V
G
D
T
Q
Y
G
P
P
V
D
V
W
A
I
G
C
V
F
A
E
L
L
S
-
G
V
P
L
W
P
G
K
S
D
V
D
Q
L
Y
L
I
R
K
T
L
G
----------
D
L
I
P
R
H
Q
-
Q
V
-
F
S
---
T
---
N
Q
Y
F
S
G
V
K
I
P
D
P
E
D
M
E
P
L
E
L
K
F
P
-
N
I
-
S
Y
P
A
L
G
L
L
K
G
C
L
H
M
D
P
T
E
R
L
T
C
E
Q
L
L
H
H
P
Y
F
E
N
I
R
------------------------------------------------------------------
110
HHSearch
97.81
98%
-134
- C1 -
4AGU
1
CDKL1_HUMAN
A:
[3-292]
-
E
K
Y
E
K
I
G
K
I
G
E
G
S
Y
G
V
V
F
K
C
R
N
R
-
D
T
G
Q
I
V
A
I
K
K
F
L
E
-
S
E
D
-
P
V
I
K
K
I
A
L
R
E
I
R
M
L
K
Q
L
K
H
P
N
L
V
N
L
L
E
V
-----
F
R
------
R
K
-----
R
R
L
H
L
V
F
E
Y
C
D
H
T
V
L
H
E
L
D
---
R
Y
Q
-
R
G
V
P
E
H
L
V
K
S
I
T
W
Q
T
L
Q
A
V
N
F
C
H
K
H
N
C
I
H
R
D
V
K
P
E
N
I
L
I
T
K
H
-
S
V
I
K
L
C
D
F
G
F
A
R
L
L
T
-------------
R
W
Y
R
S
P
E
L
L
V
G
D
T
Q
Y
G
P
P
V
D
V
W
A
I
G
C
V
F
A
E
L
L
S
-
G
V
P
L
W
P
G
K
S
D
V
D
Q
L
Y
L
I
R
K
T
L
G
----------
D
L
I
P
R
H
Q
-
Q
V
-
F
S
---
T
---
N
Q
Y
F
S
G
V
K
I
P
D
P
E
D
M
E
P
L
E
L
K
F
P
-
N
I
-
S
Y
P
A
L
G
L
L
K
G
C
L
H
M
D
P
T
E
R
L
T
C
E
Q
L
L
H
H
P
Y
F
E
N
I
R
------------------------------------------------------------------
1
PsiBlast_PDB
97.81
98%
-134
- C1 -
4AGU
1
CDKL1_HUMAN
A:
[3-292]
-
E
K
Y
E
K
I
G
K
I
G
E
G
S
Y
G
V
V
F
K
C
R
N
R
-
D
T
G
Q
I
V
A
I
K
K
F
L
E
-
S
E
D
-
P
V
I
K
K
I
A
L
R
E
I
R
M
L
K
Q
L
K
H
P
N
L
V
N
L
L
E
V
-----
F
R
------
R
K
-----
R
R
L
H
L
V
F
E
Y
C
D
H
T
V
L
H
E
L
D
---
R
Y
Q
-
R
G
V
P
E
H
L
V
K
S
I
T
W
Q
T
L
Q
A
V
N
F
C
H
K
H
N
C
I
H
R
D
V
K
P
E
N
I
L
I
T
K
H
-
S
V
I
K
L
C
D
F
G
F
A
R
L
L
T
-------------
R
W
Y
R
S
P
E
L
L
V
G
D
T
Q
Y
G
P
P
V
D
V
W
A
I
G
C
V
F
A
E
L
L
S
-
G
V
P
L
W
P
G
K
S
D
V
D
Q
L
Y
L
I
R
K
T
L
G
----------
D
L
I
P
R
H
Q
-
Q
V
-
F
S
---
T
---
N
Q
Y
F
S
G
V
K
I
P
D
P
E
D
M
E
P
L
E
L
K
F
P
-
N
I
-
S
Y
P
A
L
G
L
L
K
G
C
L
H
M
D
P
T
E
R
L
T
C
E
Q
L
L
H
H
P
Y
F
E
N
I
R
------------------------------------------------------------------
22
PsiBlast_CBE
96.11
98%
-135
- C1 -
4AGU
1
CDKL1_HUMAN
B:
[4-293]
--
K
Y
E
K
I
G
K
I
G
E
G
S
Y
G
V
V
F
K
C
R
N
R
-
D
T
G
Q
I
V
A
I
K
K
F
L
E
-
S
--
D
P
V
I
K
K
I
A
L
R
E
I
R
M
L
K
Q
L
K
H
P
N
L
V
N
L
L
E
V
-----
F
R
------
R
K
-----
R
R
L
H
L
V
F
E
Y
C
D
H
T
V
L
H
E
L
D
---
R
Y
Q
-
R
G
V
P
E
H
L
V
K
S
I
T
W
Q
T
L
Q
A
V
N
F
C
H
K
H
N
C
I
H
R
D
V
K
P
E
N
I
L
I
T
K
H
-
S
V
I
K
L
C
D
F
G
F
A
R
L
L
T
-------------
R
W
Y
R
S
P
E
L
L
V
G
D
T
Q
Y
G
P
P
V
D
V
W
A
I
G
C
V
F
A
E
L
L
S
-
G
V
P
L
W
P
G
K
S
D
V
D
Q
L
Y
L
I
R
K
T
L
G
----------
D
L
I
P
R
H
Q
-
Q
V
-
F
S
---
T
---
N
Q
Y
F
S
G
V
K
I
P
D
P
E
D
M
E
P
L
E
L
K
F
P
-
N
I
-
S
Y
P
A
L
G
L
L
K
G
C
L
H
M
D
P
T
E
R
L
T
C
E
Q
L
L
H
H
P
Y
F
E
N
I
R
E
-----------------------------------------------------------------
111
HHSearch
79.41
57%
-132
- C1 -
4AAA
7
CDKL2_HUMAN
A:
[24-319]
M
E
K
Y
E
N
L
G
L
V
G
E
G
S
Y
G
M
V
M
K
C
R
N
K
-
D
T
G
R
I
V
A
I
K
K
F
L
E
-
S
D
D
D
K
M
V
K
K
I
A
M
R
E
I
K
L
L
K
Q
L
R
H
E
N
L
V
N
L
L
E
V
-----
C
K
------
K
K
-----
K
R
W
Y
L
V
F
E
F
V
D
H
T
I
L
D
D
L
E
---
L
F
P
-
N
G
L
D
Y
Q
V
V
Q
K
Y
L
F
Q
I
I
N
G
I
G
F
C
H
S
H
N
I
I
H
R
D
I
K
P
E
N
I
L
V
S
Q
S
-
G
V
V
K
L
C
D
F
G
F
A
-------------
E
V
A
T
R
W
Y
R
A
P
E
L
L
V
G
D
V
K
Y
G
K
A
V
D
V
W
A
I
G
C
L
V
T
E
M
F
M
-
G
E
P
L
F
P
G
D
S
D
I
D
Q
L
Y
H
I
M
M
C
L
G
----------
N
L
I
P
R
H
Q
-
E
L
-
F
N
---
K
---
N
P
V
F
A
G
V
R
L
P
E
I
K
E
R
E
P
L
E
R
R
Y
P
-
K
L
-
S
E
V
V
I
D
L
A
K
K
C
L
H
I
D
P
D
K
R
P
F
C
A
E
L
L
H
H
D
F
F
Q
M
D
G
F
A
E
R
F
S
Q
E
L
Q
L
-------------------------------------------------------
2
PsiBlast_PDB
78.47
57%
-135
- C1 -
4AAA
7
CDKL2_HUMAN
A:
[24-311]
M
E
K
Y
E
N
L
G
L
V
G
E
G
S
Y
G
M
V
M
K
C
R
N
K
-
D
T
G
R
I
V
A
I
K
K
F
L
E
-
S
D
D
D
K
M
V
K
K
I
A
M
R
E
I
K
L
L
K
Q
L
R
H
E
N
L
V
N
L
L
E
V
-----
C
K
------
K
K
-----
K
R
W
Y
L
V
F
E
F
V
D
H
T
I
L
D
D
L
E
---
L
F
P
-
N
G
L
D
Y
Q
V
V
Q
K
Y
L
F
Q
I
I
N
G
I
G
F
C
H
S
H
N
I
I
H
R
D
I
K
P
E
N
I
L
V
S
Q
S
-
G
V
V
K
L
C
D
F
G
F
A
-------------
E
V
A
T
R
W
Y
R
A
P
E
L
L
V
G
D
V
K
Y
G
K
A
V
D
V
W
A
I
G
C
L
V
T
E
M
F
M
-
G
E
P
L
F
P
G
D
S
D
I
D
Q
L
Y
H
I
M
M
C
L
G
----------
N
L
I
P
R
H
Q
-
E
L
-
F
N
---
K
---
N
P
V
F
A
G
V
R
L
P
E
I
K
E
R
E
P
L
E
R
R
Y
P
-
K
L
-
S
E
V
V
I
D
L
A
K
K
C
L
H
I
D
P
D
K
R
P
F
C
A
E
L
L
H
H
D
F
F
Q
M
D
G
F
A
E
R
F
S
Q
E
L
Q
L
-------------------------------------------------------
3
PsiBlast_PDB
77.60
57%
-134
- C1 -
4BBM
3
CDKL2_HUMAN
A:
[24-311]
M
E
K
Y
E
N
L
G
L
V
G
--
S
Y
G
M
V
M
K
C
R
N
K
-
D
T
G
R
I
V
A
I
K
K
F
L
E
-
S
D
D
D
K
M
V
K
K
I
A
M
R
E
I
K
L
L
K
Q
L
R
H
E
N
L
V
N
L
L
E
V
-----
C
K
------
K
K
-----
K
R
W
Y
L
V
F
E
F
V
D
H
T
I
L
D
D
L
E
---
L
F
P
-
N
G
L
D
Y
Q
V
V
Q
K
Y
L
F
Q
I
I
N
G
I
G
F
C
H
S
H
N
I
I
H
R
D
I
K
P
E
N
I
L
V
S
Q
S
-
G
V
V
K
L
C
D
F
G
F
A
R
T
L
A
-
A
P
G
E
V
Y
D
D
E
V
A
T
R
W
Y
R
A
P
E
L
L
V
G
D
V
K
Y
G
K
A
V
D
V
W
A
I
G
C
L
V
T
E
M
F
M
-
G
E
P
L
F
P
G
D
S
D
I
D
Q
L
Y
H
I
M
M
C
L
G
----------
N
L
I
P
R
H
Q
-
E
L
-
F
N
---
K
---
N
P
V
F
A
G
V
R
L
P
E
I
K
E
R
E
P
L
E
R
R
Y
P
-
K
L
-
S
E
V
V
I
D
L
A
K
K
C
L
H
I
D
P
D
K
R
P
F
C
A
E
L
L
H
H
D
F
F
Q
M
D
G
F
A
E
R
F
S
Q
E
L
Q
L
K
V
Q
K
D
A
-------------------------------------------------
4
PsiBlast_PDB
74.49
48%
-115
- C1 -
3ZDU
3
CDKL3_HUMAN
A:
[2-299]
M
E
M
Y
E
T
L
G
K
V
G
E
G
S
Y
G
T
V
M
K
C
K
H
K
-
N
T
G
Q
I
V
A
I
K
I
F
Y
---------
N
K
I
A
M
R
E
I
K
F
L
K
Q
F
H
H
E
N
L
V
N
L
I
E
V
-----
F
R
------
Q
K
-----
K
K
I
H
L
V
F
E
F
I
D
H
T
V
L
D
E
L
Q
---
H
Y
C
-
H
G
L
E
S
K
R
L
R
K
Y
L
F
Q
I
L
R
A
I
D
Y
L
H
S
N
N
I
I
H
R
D
I
K
P
E
N
I
L
V
S
Q
S
-
G
I
T
K
L
C
D
F
G
F
A
R
T
------
D
I
Y
D
D
E
V
A
T
R
W
Y
R
A
P
E
L
V
L
K
D
T
S
Y
G
K
P
V
D
I
W
A
L
G
C
M
I
I
E
M
A
T
-
G
N
P
Y
L
P
S
S
S
D
L
D
L
L
H
K
I
V
L
K
V
G
----------
N
L
S
P
H
L
Q
-
N
I
-
F
S
---
K
---
S
P
I
F
A
G
V
V
L
P
Q
V
Q
H
P
K
N
A
R
K
K
Y
P
-
K
L
-
N
G
L
L
A
D
I
V
H
A
C
L
Q
I
D
P
A
D
R
I
S
S
S
D
L
L
H
H
E
Y
F
T
R
D
G
F
I
E
K
F
M
P
E
L
K
A
K
L
L
Q
E
A
K
V
-----------------------------------------------
23
PsiBlast_CBE
73.82
57%
-136
- C1 -
4BBM
3
CDKL2_HUMAN
B:
[24-311]
M
E
K
Y
E
N
L
G
-----
S
Y
G
M
V
M
K
C
R
N
K
-
D
T
G
R
I
V
A
I
K
K
F
----------
K
K
I
A
M
R
E
I
K
L
L
K
Q
L
R
H
E
N
L
V
N
L
L
E
V
-----
C
-----------------
Y
L
V
F
E
F
V
D
H
T
I
L
D
D
L
E
---
L
F
P
-
N
G
L
D
Y
Q
V
V
Q
K
Y
L
F
Q
I
I
N
G
I
G
F
C
H
S
H
N
I
I
H
R
D
I
K
P
E
N
I
L
V
S
Q
S
-
G
V
V
K
L
C
D
F
G
F
A
R
T
L
A
-
A
P
G
E
V
Y
D
D
E
V
A
T
R
W
Y
R
A
P
E
L
L
V
G
D
V
K
Y
G
K
A
V
D
V
W
A
I
G
C
L
V
T
E
M
F
M
-
G
E
P
L
F
P
G
D
S
D
I
D
Q
L
Y
H
I
M
M
C
L
G
----------
N
L
I
P
R
H
Q
-
E
L
-
F
N
---
K
---
N
P
V
F
A
G
V
R
L
P
E
I
K
E
R
E
P
L
E
R
R
Y
P
-
K
L
-
S
E
V
V
I
D
L
A
K
K
C
L
H
I
D
P
D
K
R
P
F
C
A
E
L
L
H
H
D
F
F
Q
M
D
G
F
A
E
R
F
S
Q
E
L
Q
L
K
V
Q
K
D
A
-------------------------------------------------
113
HHSearch
72.74
49%
-118
- C1 -
3ZDU
3
CDKL3_HUMAN
A:
[2-291]
M
E
M
Y
E
T
L
G
K
V
G
E
G
S
Y
G
T
V
M
K
C
K
H
K
-
N
T
G
Q
I
V
A
I
K
I
F
Y
---------
N
K
I
A
M
R
E
I
K
F
L
K
Q
F
H
H
E
N
L
V
N
L
I
E
V
-----
F
R
------
Q
K
-----
K
K
I
H
L
V
F
E
F
I
D
H
T
V
L
D
E
L
Q
---
H
Y
C
-
H
G
L
E
S
K
R
L
R
K
Y
L
F
Q
I
L
R
A
I
D
Y
L
H
S
N
N
I
I
H
R
D
I
K
P
E
N
I
L
V
S
Q
S
-
G
I
T
K
L
C
D
F
G
F
A
R
T
------
D
I
Y
D
D
E
V
A
T
R
W
Y
R
A
P
E
L
V
L
K
D
T
S
Y
G
K
P
V
D
I
W
A
L
G
C
M
I
I
E
M
A
T
-
G
N
P
Y
L
P
S
S
S
D
L
D
L
L
H
K
I
V
L
K
V
G
----------
N
L
S
P
H
L
Q
-
N
I
-
F
S
---
K
---
S
P
I
F
A
G
V
V
L
P
Q
V
Q
H
P
K
N
A
R
K
K
Y
P
-
K
L
-
N
G
L
L
A
D
I
V
H
A
C
L
Q
I
D
P
A
D
R
I
S
S
S
D
L
L
H
H
E
Y
F
T
R
D
G
F
I
E
K
F
M
P
E
L
K
A
K
L
L
Q
E
A
K
V
-----------------------------------------------
15
PsiBlast_PDB
72.52
39%
-123
- C1 -
1FVT
1
CDK2_HUMAN
A:
[1-289]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
-
L
T
G
E
V
V
A
L
K
K
I
R
--------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
-----
I
H
------
T
E
-----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
---
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
-
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
----------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
TPDEVVWPGV
T
S
M
P
D
Y
K
-
P
S
-
F
P
K
W
-
A
---
R
Q
D
F
S
K
V
V
P
P
L
D
E
D
----------------
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
----------------------------------------------------------
26
PsiBlast_CBE
72.15
39%
-120
- C1 -
4LYN
1
CDK2_HUMAN
A:
[1-289]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
-
L
T
G
E
V
V
A
L
K
K
I
R
L
-
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
-----
I
H
------
T
E
-----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
---
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
-
G
A
I
K
L
A
D
F
G
L
A
R
A
F
------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
TPDEVVWPGV
T
S
M
P
D
Y
K
-
P
S
-
F
P
K
W
-
A
---
R
Q
D
F
S
K
V
V
P
P
L
D
E
D
----------------
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
----------------------------------------------------------
99
PsiBlast_CBE
72.10
39%
-124
- C1 -
2R64
1
CDK2_HUMAN
A:
[1-289]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
-
L
T
G
E
V
V
A
L
K
K
I
---------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
-----
I
H
------
T
E
-----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
---
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
-
G
A
I
K
L
A
D
F
G
L
A
R
A
F
------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
TPDEVVWPGV
T
S
M
P
D
Y
K
-
P
S
-
F
P
K
W
-
A
---
R
Q
D
F
S
K
V
V
P
P
L
D
E
D
----------------
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
----------------------------------------------------------
112
HHSearch
71.80
47%
-127
- C1 -
4BGQ
3
CDKL5_HUMAN
A:
[11-302]
M
N
K
F
E
I
L
G
V
V
G
E
G
A
Y
G
V
V
L
K
C
R
H
K
-
E
T
H
E
I
V
A
I
K
K
F
K
--------
V
K
E
T
T
L
R
E
L
K
M
L
R
T
L
K
Q
E
N
I
V
E
L
K
E
A
-----
F
R
------
R
R
-----
G
K
L
Y
L
V
F
E
Y
V
E
K
N
M
L
E
L
L
E
---
E
M
P
-
N
G
V
P
P
E
K
V
K
S
Y
I
Y
Q
L
I
K
A
I
H
W
C
H
K
N
D
I
V
H
R
D
I
K
P
E
N
L
L
I
S
H
N
-
D
V
L
K
L
C
D
F
G
F
A
R
N
L
S
-
E
----------
T
R
W
Y
R
S
P
E
L
L
L
G
-
A
P
Y
G
K
S
V
D
M
W
S
V
G
C
I
L
G
E
L
S
D
-
G
Q
P
L
F
P
G
E
S
E
I
D
Q
L
F
T
I
Q
K
V
L
G
----------
P
L
P
S
E
Q
M
-
K
L
-
F
Y
---
S
---
N
P
R
F
H
G
L
R
F
P
A
V
N
H
P
Q
S
L
E
R
R
Y
L
G
I
L
-
N
S
V
L
L
D
L
M
K
N
L
L
K
L
D
P
A
D
R
Y
L
T
E
Q
C
L
N
H
P
T
F
Q
T
Q
R
L
-----------------------------------------------------------------
92
PsiBlast_CBE
71.80
39%
-123
- C1 -
2VTH
2
CDK2_HUMAN
A:
[1-289]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
-
L
T
G
E
V
V
A
L
K
K
I
R
----------
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
-----
I
H
------
T
E
-----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
---
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
-
G
A
I
K
L
A
D
F
G
L
A
R
A
F
------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
TPDEVVWPGV
T
S
M
P
D
Y
K
-
P
S
-
F
P
K
W
-
A
---
R
Q
D
F
S
K
V
V
P
P
L
D
E
D
----------------
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
----------------------------------------------------------
78
PsiBlast_CBE
71.79
39%
-124
- C1 -
2W06
2
CDK2_HUMAN
A:
[1-289]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
-
L
T
G
E
V
V
A
L
K
K
I
R
--------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
-----
I
H
------
T
E
-----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
---
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
-
G
A
I
K
L
A
D
F
G
L
A
R
A
F
----------
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
TPDEVVWPGV
T
S
M
P
D
Y
K
-
P
S
-
F
P
K
W
-
A
---
R
Q
D
F
S
K
V
V
P
P
L
D
E
D
----------------
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
----------------------------------------------------------
58
PsiBlast_CBE
71.79
39%
-119
- C1 -
3LFQ
1
CDK2_HUMAN
A:
[1-289]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
-
L
T
G
E
V
V
A
L
K
K
I
R
----------
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
-----
I
H
------
T
E
-----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
---
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
-
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
TPDEVVWPGV
T
S
M
P
D
Y
K
-
P
S
-
F
P
K
W
-
A
---
R
Q
D
F
S
K
V
V
P
P
L
D
E
D
----------------
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
----------------------------------------------------------
19
PsiBlast_PDB
71.70
39%
-122
- C1 -
1JVP
1
CDK2_HUMAN
P:
[1-289]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
-
L
T
G
E
V
V
A
L
K
K
I
R
--------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
-----
I
H
------
T
E
-----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
---
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
-
G
A
I
K
L
A
D
F
G
L
A
R
A
F
-----------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
TPDEVVWPGV
T
S
M
P
D
Y
K
-
P
S
-
F
P
KW-
A
---
R
Q
D
F
S
K
V
V
P
P
L
D
E
D
----------------
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
----------------------------------------------------------
62
PsiBlast_CBE
71.68
39%
-123
- C1 -
3FZ1
1
CDK2_HUMAN
A:
[1-289]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
-
L
T
G
E
V
V
A
L
K
K
I
R
--------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
-----
I
H
------
T
E
-----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
---
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
-
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
--------
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
TPDEVVWPGV
T
S
M
P
D
Y
K
-
P
S
-
F
P
K
W
-
A
---
R
Q
D
F
S
K
V
V
P
P
L
D
E
D
----------------
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
----------------------------------------------------------
91
PsiBlast_CBE
71.63
39%
-124
- C1 -
2VTI
1
CDK2_HUMAN
A:
[1-289]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
-
L
T
G
E
V
V
A
L
K
K
I
---------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
-----
I
H
------
T
E
-----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
---
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
-
G
A
I
K
L
A
D
F
G
L
A
R
A
F
-----------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
TPDEVVWPGV
T
S
M
P
D
Y
K
-
P
S
-
F
P
K
W
-
A
---
R
Q
D
F
S
K
V
V
P
P
L
D
E
D
----------------
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
----------------------------------------------------------
86
PsiBlast_CBE
71.60
39%
-122
- C1 -
2VTO
1
CDK2_HUMAN
A:
[1-289]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
-
L
T
G
E
V
V
A
L
K
K
I
R
--------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
-----
I
H
------
T
E
-----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
---
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
-
G
A
I
K
L
A
D
F
G
L
A
R
A
F
---------
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
TPDEVVWPGV
T
S
M
P
D
Y
K
-
P
S
-
F
P
K
W
-
A
---
R
Q
D
F
S
K
V
V
P
P
L
D
E
D
----------------
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
----------------------------------------------------------
11
PsiBlast_PDB
71.57
39%
-124
- C1 -
1CKP
2
CDK2_HUMAN
A:
[1-289]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
-
L
T
G
E
V
V
A
L
K
K
I
---------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
-----
I
H
------
T
E
-----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
---
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
-
G
A
I
K
L
A
D
F
G
L
A
R
A
F
------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
TPDEVVWPGV
T
S
M
P
D
Y
K
-
P
S
-
F
P
K
W
-
A
---
R
Q
D
F
S
K
V
V
P
P
L
D
E
D
----------------
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
----------------------------------------------------------
5
PsiBlast_PDB
71.33
47%
-128
- C1 -
4BGQ
3
CDKL5_HUMAN
A:
[11-302]
M
N
K
F
E
I
L
G
V
V
G
E
G
A
Y
G
V
V
L
K
C
R
H
K
-
E
T
H
E
I
V
A
I
K
K
F
K
--------
V
K
E
T
T
L
R
E
L
K
M
L
R
T
L
K
Q
E
N
I
V
E
L
K
E
A
-----
F
R
------
R
R
-----
G
K
L
Y
L
V
F
E
Y
V
E
K
N
M
L
E
L
L
E
---
E
M
P
-
N
G
V
P
P
E
K
V
K
S
Y
I
Y
Q
L
I
K
A
I
H
W
C
H
K
N
D
I
V
H
R
D
I
K
P
E
N
L
L
I
S
H
N
-
D
V
L
K
L
C
D
F
G
F
A
R
N
L
S
E-----------
T
R
W
Y
R
S
P
E
L
L
L
G
-
A
P
Y
G
K
S
V
D
M
W
S
V
G
C
I
L
G
E
L
S
D
-
G
Q
P
L
F
P
G
E
S
E
I
D
Q
L
F
T
I
Q
K
V
L
G
----------
P
L
P
S
E
Q
M
-
K
L
-
F
Y
---
S
---
N
P
R
F
H
G
L
R
F
P
A
V
N
H
P
Q
S
L
E
R
R
Y
L
-
G
I
L
N
S
V
L
L
D
L
M
K
N
L
L
K
L
D
P
A
D
R
Y
L
T
E
Q
C
L
N
H
P
T
F
Q
T
Q
R
L
-----------------------------------------------------------------
82
PsiBlast_CBE
71.27
39%
-120
- C1 -
2VTS
1
CDK2_HUMAN
A:
[1-289]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
-
L
T
G
E
V
V
A
L
K
K
I
R
---------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
-----
I
H
------
T
E
-----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
---
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
-
G
A
I
K
L
A
D
F
G
L
A
R
A
F
---------
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
TPDEVVWPGV
T
S
M
P
D
Y
K
-
P
S
-
F
P
K
W
-
A
---
R
Q
D
F
S
K
V
V
P
P
L
D
E
D
----------------
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
----------------------------------------------------------
93
PsiBlast_CBE
71.01
39%
-123
- C1 -
2VTA
3
CDK2_HUMAN
A:
[1-289]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
-
L
T
G
E
V
V
A
L
K
K
I
R
----------
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
-----
I
H
------
T
E
-----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
---
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
-
G
A
I
K
L
A
D
F
G
L
A
R
A
F
------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
TPDEVVWPGV
T
S
M
P
D
Y
K
-
P
S
-
F
P
K
W
-
A
---
R
Q
D
F
S
K
V
V
P
P
L
D
E
D
----------------
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
----------------------------------------------------------
96
PsiBlast_CBE
70.97
39%
-126
- C1 -
2UZN
1
CDK2_HUMAN
A:
[1-289]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
-
L
T
G
E
V
V
A
L
K
K
I
----------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
-----
I
H
------
T
E
-----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
---
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
-
G
A
I
K
L
A
D
F
G
L
A
R
A
F
-----------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
TPDEVVWPGV
T
S
M
P
D
Y
K
-
P
S
-
F
P
K
W
-
A
---
R
Q
D
F
S
K
V
V
P
P
L
D
E
D
----------------
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
----------------------------------------------------------
57
PsiBlast_CBE
70.89
39%
-119
- C1 -
3LFS
1
CDK2_HUMAN
A:
[1-289]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
-
L
T
G
E
V
V
A
L
K
K
I
R
---------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
-----
I
H
------
T
E
-----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
---
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
-
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
TPDEVVWPGV
T
S
M
P
D
Y
K
-
P
S
-
F
P
K
W
-
A
---
R
Q
D
F
S
K
V
V
P
P
L
D
E
D
----------------
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
----------------------------------------------------------
71
PsiBlast_CBE
70.70
39%
-116
- C1 -
2XMY
1
CDK2_HUMAN
A:
[1-289]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
-
L
T
G
E
V
V
A
L
K
K
I
R
L
-
D
T
---
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
-----
I
H
------
T
E
-----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
---
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
-
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
TPDEVVWPGV
T
S
M
P
D
Y
K
-
P
S
-
F
P
K
W
-
A
---
R
Q
D
F
S
K
V
V
P
P
L
D
E
D
----------------
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
----------------------------------------------------------
95
PsiBlast_CBE
70.61
39%
-115
- C1 -
2UZO
1
CDK2_HUMAN
A:
[1-289]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
-
L
T
G
E
V
V
A
L
K
K
I
R
L
-------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
-----
I
H
------
T
E
-----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
---
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
-
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
TPDEVVWPGV
T
S
M
P
D
Y
K
-
P
S
-
F
P
K
W
-
A
---
R
Q
D
F
S
K
V
V
P
P
L
D
E
D
----------------
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
------------------------------------------------------------
27
PsiBlast_CBE
70.58
39%
-115
- C1 -
4KD1
2
CDK2_HUMAN
A:
[1-289]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
-
L
T
G
E
V
V
A
L
K
K
I
R
L
-
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
-----
I
H
------
T
E
-----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
---
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
-
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
TPDEVVWPGV
T
S
M
P
D
Y
K
-
P
S
-
F
P
K
W
-
A
---
R
Q
D
F
S
K
V
V
P
P
L
D
E
D
----------------
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
----------------------------------------------------------
47
PsiBlast_CBE
70.54
39%
-118
- C1 -
3UNK
1
CDK2_HUMAN
A:
[1-289]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
-
L
T
G
E
V
V
A
L
K
K
I
R
----
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
-----
I
H
------
T
E
-----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
---
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
-
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
TPDEVVWPGV
T
S
M
P
D
Y
K
-
P
S
-
F
P
K
W
-
A
---
R
Q
D
F
S
K
V
V
P
P
L
D
E
D
----------------
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
----------------------------------------------------------
51
PsiBlast_CBE
70.46
39%
-120
- C1 -
3TIY
12
CDK2_HUMAN
A:
[2-289]
-
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
-
L
T
G
E
V
V
A
L
K
K
I
R
-----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
-----
I
H
------
T
E
-----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
---
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
-
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
TPDEVVWPGV
T
S
M
P
D
Y
K
-
P
S
-
F
P
K
W
-
A
---
R
Q
D
F
S
K
V
V
P
P
L
D
E
D
----------------
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
----------------------------------------------------------
83
PsiBlast_CBE
70.41
39%
-115
- C1 -
2VTR
1
CDK2_HUMAN
A:
[1-289]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
-
L
T
G
E
V
V
A
L
K
K
I
R
---------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
-----
I
H
------
T
E
-----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
---
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
-
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
TPDEVVWPGV
T
S
M
P
D
Y
K
-
P
S
-
F
P
K
W
-
A
---
R
Q
D
F
S
K
V
V
P
P
L
D
E
D
----------------
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
----------------------------------------------------------
46
PsiBlast_CBE
70.34
39%
-121
- C1 -
3WBL
1
CDK2_HUMAN
A:
[1-289]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
T
G
E
V
V
A
L
K
K
I
R
L
------
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
-----
I
H
------
T
E
-----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
---
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
-
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
----------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
TPDEVVWPGV
T
S
M
P
D
Y
K
-
P
S
-
F
P
K
W
-
A
---
R
Q
D
F
S
K
V
V
P
P
L
D
E
D
----------------
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
----------------------------------------------------------
43
PsiBlast_CBE
70.18
39%
-124
- C1 -
4D1X
1
CDK2_HUMAN
A:
[3-289]
--
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
-
L
T
G
E
V
V
A
L
K
K
I
------------
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
-----
I
H
------
T
E
-----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
---
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
-
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
------------
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
TPDEVVWPGV
T
S
M
P
D
Y
K
-
P
S
-
F
P
K
W
-
A
---
R
Q
D
F
S
K
V
V
P
P
L
D
E
D
----------------
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
----------------------------------------------------------
76
PsiBlast_CBE
70.12
39%
-119
- C1 -
2W1H
1
CDK2_HUMAN
A:
[1-289]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
-
L
T
G
E
V
V
A
L
K
K
I
R
-----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
-----
I
H
------
T
E
-----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
---
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
-
G
A
I
K
L
A
D
F
G
L
A
R
A
F
------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
TPDEVVWPGV
T
S
M
P
D
Y
K
-
P
S
-
F
P
K
W
-
A
---
R
Q
D
F
S
K
V
V
P
P
L
D
E
D
----------------
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
----------------------------------------------------------
90
PsiBlast_CBE
70.01
39%
-117
- C1 -
2VTJ
2
CDK2_HUMAN
A:
[1-289]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
-
L
T
G
E
V
V
A
L
K
K
I
R
----------
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
-----
I
H
------
T
E
-----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
---
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
-
G
A
I
K
L
A
D
F
G
L
A
R
--------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
TPDEVVWPGV
T
S
M
P
D
Y
K
-
P
S
-
F
P
K
W
-
A
---
R
Q
D
F
S
K
V
V
P
P
L
D
E
D
----------------
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
----------------------------------------------------------
50
PsiBlast_CBE
69.99
39%
-121
- C1 -
3TIZ
9
CDK2_HUMAN
A:
[2-289]
-
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
-
L
T
G
E
V
V
A
L
K
K
I
R
-----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
-----
I
H
------
T
E
-----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
---
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
-
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
TPDEVVWPGV
T
S
M
P
D
Y
K
-
P
S
-
F
P
K
W
-
A
---
R
Q
D
F
S
K
V
V
P
P
L
D
E
D
----------------
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
----------------------------------------------------------
59
PsiBlast_CBE
69.97
39%
-123
- C1 -
3LFN
1
CDK2_HUMAN
A:
[1-289]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
-
L
T
G
E
V
V
A
L
K
K
I
R
-----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
-----
I
H
------
T
E
-----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
---
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
-
G
A
I
K
L
A
D
F
G
L
A
R
A
----------
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
TPDEVVWPGV
T
S
M
P
D
Y
K
-
P
S
-
F
P
K
W
-
A
---
R
Q
D
F
S
K
V
V
P
P
L
D
E
D
----------------
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
----------------------------------------------------------
89
PsiBlast_CBE
69.87
39%
-117
- C1 -
2VTL
1
CDK2_HUMAN
A:
[1-289]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
-
L
T
G
E
V
V
A
L
K
K
I
---------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
-----
I
H
------
T
E
-----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
---
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
-
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
TPDEVVWPGV
T
S
M
P
D
Y
K
-
P
S
-
F
P
K
W
-
A
---
R
Q
D
F
S
K
V
V
P
P
L
D
E
D
----------------
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
----------------------------------------------------------
55
PsiBlast_CBE
69.84
39%
-120
- C1 -
3S2P
1
CDK2_HUMAN
A:
[1-289]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
-
L
T
G
E
V
V
A
L
K
K
I
---------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
-----
I
H
------
T
E
-----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
---
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
-
G
A
I
K
L
A
D
F
G
L
A
R
A
F
------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
TPDEVVWPGV
T
S
M
P
D
Y
K
-
P
S
-
F
P
K
W
-
A
---
R
Q
D
F
S
K
V
V
P
P
L
D
E
D
----------------
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
----------------------------------------------------------
56
PsiBlast_CBE
69.64
39%
-122
- C1 -
3NS9
1
CDK2_HUMAN
A:
[3-289]
--
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
-
L
T
G
E
V
V
A
L
K
K
I
--------
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
-----
I
H
------
T
E
-----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
---
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
-
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
TPDEVVWPGV
T
S
M
P
D
Y
K
-
P
S
-
F
P
K
W
-
A
---
R
Q
D
F
S
K
V
V
P
P
L
D
E
D
----------------
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
----------------------------------------------------------
13
PsiBlast_PDB
69.53
39%
-125
- C1 -
1DI8
1
CDK2_HUMAN
A:
[1-289]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
-
L
T
G
E
V
V
A
L
K
K
I
R
-------
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
-----
I
H
------
T
E
-----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
---
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
-
G
A
I
K
L
A
D
F
G
L
A
R
A
F
----------
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
TPDEVVWPGV
T
S
M
P
D
Y
K
-
P
S
-
F
P
K
W
-
A
---
R
Q
D
F
S
K
V
V
P
P
L
D
E
D
----------------
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
----------------------------------------------------------
48
PsiBlast_CBE
69.51
39%
-117
- C1 -
3UNJ
1
CDK2_HUMAN
A:
[1-289]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
-
L
T
G
E
V
V
A
L
K
K
I
R
-----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
-----
I
H
------
T
E
-----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
---
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
-
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
TPDEVVWPGV
T
S
M
P
D
Y
K
-
P
S
-
F
P
K
W
-
A
---
R
Q
D
F
S
K
V
V
P
P
L
D
E
D
----------------
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
----------------------------------------------------------
49
PsiBlast_CBE
69.34
39%
-122
- C1 -
3ULI
1
CDK2_HUMAN
A:
[1-289]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
-
L
T
G
E
V
V
A
L
K
K
I
R
L
-
D
-----
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
-----
I
H
------
T
E
-----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
---
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
-
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
-------
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
TPDEVVWPGV
T
S
M
P
D
Y
K
-
P
S
-
F
P
K
W
-
A
---
R
Q
D
F
S
K
V
V
P
P
L
D
E
D
----------------
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
----------------------------------------------------------
88
PsiBlast_CBE
69.31
39%
-116
- C1 -
2VTM
1
CDK2_HUMAN
A:
[1-289]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
-
L
T
G
E
V
V
A
L
K
K
I
---------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
-----
I
H
------
T
E
-----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
---
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
-
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
TPDEVVWPGV
T
S
M
P
D
Y
K
-
P
S
-
F
P
K
W
-
A
---
R
Q
D
F
S
K
V
V
P
P
L
D
E
D
----------------
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
----------------------------------------------------------
16
PsiBlast_PDB
69.28
39%
-113
- C1 -
1FVV
1
CDK2_HUMAN
A:
[1-289]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
-
L
T
G
E
V
V
A
L
K
K
I
R
L
-
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
-----
I
H
------
T
E
-----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
---
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
-
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
TPDEVVWPGV
T
S
M
P
D
Y
K
-
P
S
-
F
P
K
W
-
A
---
R
Q
D
F
S
K
V
V
P
P
L
D
E
D
----------------
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
----------------------------------------------------------
85
PsiBlast_CBE
69.27
39%
-121
- C1 -
2VTP
1
CDK2_HUMAN
A:
[1-289]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
-
L
T
G
E
V
V
A
L
K
K
I
---------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
-----
I
H
------
T
E
-----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
---
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
-
G
A
I
K
L
A
D
F
G
L
A
R
A
F
----------
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
TPDEVVWPGV
T
S
M
P
D
Y
K
-
P
S
-
F
P
K
W
-
A
---
R
Q
D
F
S
K
V
V
P
P
L
D
E
D
----------------
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
----------------------------------------------------------
20
PsiBlast_PDB
69.27
39%
-118
- C1 -
1GIH
1
CDK2_HUMAN
A:
[1-289]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
-
L
T
G
E
V
V
A
L
K
K
I
R
---------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
-----
I
H
------
T
E
-----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
---
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
-
G
A
I
K
L
A
D
F
G
L
A
---------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
TPDEVVWPGV
T
S
M
P
D
Y
K
-
P
S
-
F
P
K
W
-
A
---
R
Q
D
F
S
K
V
V
P
P
L
D
E
D
----------------
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
----------------------------------------------------------
97
PsiBlast_CBE
69.25
39%
-111
- C1 -
2UUE
1
CDK2_HUMAN
C:
[1-289]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
-
L
T
G
E
V
V
A
L
K
K
I
R
L
-
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
-----
I
H
------
T
E
-----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
---
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
-
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
TPDEVVWPGV
T
S
M
P
D
Y
K
-
P
S
-
F
P
KW-
A
---
R
Q
D
F
S
K
V
V
P
P
L
D
E
D
----------------
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
-----------------------------------------------------------
8
PsiBlast_PDB
69.16
39%
-119
- C1 -
3EZV
1
CDK2_HUMAN
A:
[3-291]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
-
L
T
G
E
V
V
A
L
K
K
I
R
--------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
-----
I
H
------
T
E
-----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
---
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
-
G
A
I
K
L
A
D
F
G
L
---------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
TPDEVVWPGV
T
S
M
P
D
Y
K
-
P
S
-
F
P
K
W
-
A
---
R
Q
D
F
S
K
V
V
P
P
L
D
E
D
----------------
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
----------------------------------------------------------
70
PsiBlast_CBE
69.09
39%
-116
- C1 -
2XNB
1
CDK2_HUMAN
A:
[1-289]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
-
L
T
G
E
V
V
A
L
K
K
I
R
L
-
D
--
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
-----
I
H
------
T
E
-----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
---
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
-
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
TPDEVVWPGV
T
S
M
P
D
Y
K
-
P
S
-
F
P
K
W
-
A
---
R
Q
D
F
S
K
V
V
P
P
L
D
E
D
----------------
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
----------------------------------------------------------
69
PsiBlast_CBE
68.88
39%
-115
- C1 -
3EID
1
CDK2_HUMAN
A:
[1-289]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
-
L
T
G
E
V
V
A
L
K
K
I
R
L
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
-----
I
H
------
T
E
-----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
---
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
-
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
P
V
R
T
Y
T
--
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
TPDEVVWPGV
T
S
M
P
D
Y
K
-
P
S
-
F
P
K
W
-
A
---
R
Q
D
F
S
K
V
V
P
P
L
D
E
D
----------------
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
-----------------------------------------------------------
68
PsiBlast_CBE
68.86
39%
-113
- C1 -
3EJ1
1
CDK2_HUMAN
A:
[1-289]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
-
L
T
G
E
V
V
A
L
K
K
I
R
L
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
-----
I
H
------
T
E
-----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
---
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
-
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
TPDEVVWPGV
T
S
M
P
D
Y
K
-
P
S
-
F
P
K
W
-
A
---
R
Q
D
F
S
K
V
V
P
P
L
D
E
D
----------------
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
----------------------------------------------------------
52
PsiBlast_CBE
68.84
39%
-119
- C1 -
3TI1
9
CDK2_HUMAN
A:
[1-289]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
-
L
T
G
E
V
V
A
L
K
K
I
R
-----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
-----
I
H
------
T
E
-----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
---
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
-
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
TPDEVVWPGV
T
S
M
P
D
Y
K
-
P
S
-
F
P
K
W
-
A
---
R
Q
D
F
S
K
V
V
P
P
L
D
E
D
----------------
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
----------------------------------------------------------
45
PsiBlast_CBE
68.81
39%
-118
- C1 -
4BGH
1
CDK2_HUMAN
A:
[1-289]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
-
L
T
G
E
V
V
A
L
K
K
I
----------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
-----
I
H
------
T
E
-----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
---
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
-
G
A
I
K
L
A
D
F
G
L
A
---------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
TPDEVVWPGV
T
S
M
P
D
Y
K
-
P
S
-
F
P
K
W
-
A
---
R
Q
D
F
S
K
V
V
P
P
L
D
E
D
----------------
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
----------------------------------------------------------
44
PsiBlast_CBE
68.78
39%
-118
- C1 -
4BZD
1
CDK2_HUMAN
A:
[2-290]
M
E
N
F
Q
K
V
E
K
I
G
E
G
-
Y
G
V
V
Y
K
A
R
N
K
-
L
T
G
E
V
V
A
L
K
K
I
R
L
-------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
-----
I
H
------
T
E
-----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
---
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
-
G
A
I
K
L
A
D
F
G
L
---------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
TPDEVVWPGV
T
S
M
P
D
Y
K
-
P
S
-
F
P
K
W
-
A
---
R
Q
D
F
S
K
V
V
P
P
L
D
E
D
----------------
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
----------------------------------------------------------
79
PsiBlast_CBE
68.64
39%
-121
- C1 -
2W05
1
CDK2_HUMAN
A:
[1-289]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
-
L
T
G
E
V
V
A
L
K
K
I
R
----------
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
-----
I
H
------
T
E
-----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
---
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
-
G
A
I
K
L
A
D
F
G
L
--------------
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
TPDEVVWPGV
T
S
M
P
D
Y
K
-
P
S
-
F
P
K
W
-
A
---
R
Q
D
F
S
K
V
V
P
P
L
D
E
D
----------------
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
----------------------------------------------------------
72
PsiBlast_CBE
68.58
39%
-110
- C1 -
2X1N
1
CDK2_HUMAN
C:
[1-289]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
-
L
T
G
E
V
V
A
L
K
K
I
R
L
-
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
-----
I
H
------
T
E
-----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
---
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
-
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
TPDEVVWPGV
T
S
M
P
D
Y
K
-
P
S
-
F
P
KW-
A
---
R
Q
D
F
S
K
V
V
P
P
L
D
E
D
----------------
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
-----------------------------------------------------------
28
PsiBlast_CBE
68.53
39%
-112
- C1 -
4FX3
1
CDK2_HUMAN
C:
[1-289]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
-
L
T
G
E
V
V
A
L
K
K
I
R
L
-
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
-----
I
H
------
T
E
-----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
---
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
-
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
TPDEVVWPGV
T
S
M
P
D
Y
K
-
P
S
-
F
P
KW-
A
---
R
Q
D
F
S
K
V
V
P
P
L
D
E
D
----------------
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
----------------------------------------------------------
74
PsiBlast_CBE
68.45
39%
-111
- C1 -
2WEV
1
CDK2_HUMAN
C:
[1-289]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
-
L
T
G
E
V
V
A
L
K
K
I
R
L
-
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
-----
I
H
------
T
E
-----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
---
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
-
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
TPDEVVWPGV
T
S
M
P
D
Y
K
-
P
S
-
F
P
KW-
A
---
R
Q
D
F
S
K
V
V
P
P
L
D
E
D
----------------
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
-----------------------------------------------------------
18
PsiBlast_PDB
68.36
39%
-121
- C1 -
1G5S
1
CDK2_HUMAN
A:
[1-289]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
-
L
T
G
E
V
V
A
L
K
K
I
R
----------
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
-----
I
H
------
T
E
-----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
---
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
-
G
A
I
K
L
A
D
F
G
L
---------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
TPDEVVWPGV
T
S
M
P
D
Y
K
-
P
S
-
F
P
K
W
-
A
---
R
Q
D
F
S
K
V
V
P
P
L
D
E
D
----------------
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
----------------------------------------------------------
94
PsiBlast_CBE
68.25
39%
-116
- C1 -
2V0D
1
CDK2_HUMAN
A:
[1-289]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
-
L
T
G
E
V
V
A
L
K
K
I
R
L
-------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
-----
I
H
------
T
E
-----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
---
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
-
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
TPDEVVWPGV
T
S
M
P
D
Y
K
-
P
S
-
F
P
K
W
-
A
---
R
Q
D
F
S
K
V
V
P
P
L
D
E
D
----------------
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
----------------------------------------------------------
29
PsiBlast_CBE
68.06
39%
-114
- C1 -
4FX3
2
CDK2_HUMAN
A:
[1-289]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
-
L
T
G
E
V
V
A
L
K
K
I
R
L
-
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
-----
I
H
------
T
E
-----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
---
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
-
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
TPDEVVWPGV
T
S
M
P
D
Y
K
-
P
S
-
F
P
K
W
-
A
---
R
Q
D
F
S
K
V
V
P
P
L
D
E
D
----------------
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
----------------------------------------------------------
98
PsiBlast_CBE
68.01
39%
-111
- C1 -
2UUE
1
CDK2_HUMAN
A:
[1-289]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
-
L
T
G
E
V
V
A
L
K
K
I
R
L
-
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
-----
I
H
------
T
E
-----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
---
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
-
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
TPDEVVWPGV
T
S
M
P
D
Y
K
-
P
S
-
F
P
K
W
-
A
---
R
Q
D
F
S
K
V
V
P
P
L
D
E
D
----------------
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
------------------------------------------------------------
81
PsiBlast_CBE
67.86
39%
-115
- C1 -
2VU3
1
CDK2_HUMAN
A:
[1-289]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
-
L
T
G
E
V
V
A
L
K
K
I
R
L
----------
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
-----
I
H
------
T
E
-----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
---
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
-
G
A
I
K
L
A
D
F
G
----
F
G
-
V
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
TPDEVVWPGV
T
S
M
P
D
Y
K
-
P
S
-
F
P
K
W
-
A
---
R
Q
D
F
S
K
V
V
P
P
L
D
E
D
----------------
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
----------------------------------------------------------
7
PsiBlast_PDB
67.81
39%
-119
- C1 -
3EZR
2
CDK2_HUMAN
A:
[3-291]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
-
L
T
G
E
V
V
A
L
K
K
I
R
--------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
-----
I
H
------
T
E
-----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
---
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
-
G
A
I
K
L
A
D
F
-------------------
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
TPDEVVWPGV
T
S
M
P
D
Y
K
-
P
S
-
F
P
K
W
-
A
---
R
Q
D
F
S
K
V
V
P
P
L
D
E
D
----------------
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
----------------------------------------------------------
9
PsiBlast_PDB
67.75
39%
-113
- C1 -
2IW8
1
CDK2_HUMAN
A:
[5-293]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
-
L
T
G
E
V
V
A
L
K
K
I
R
L
-
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
-----
I
H
------
T
E
-----
N
K
L
Y
L
V
F
E
H
V
D
Q
D
L
K
K
F
M
D
---
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
-
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
TPDEVVWPGV
T
S
M
P
D
Y
K
-
P
S
-
F
P
K
W
-
A
---
R
Q
D
F
S
K
V
V
P
P
L
D
E
D
----------------
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
-----------------------------------------------------------
87
PsiBlast_CBE
67.72
39%
-115
- C1 -
2VTN
1
CDK2_HUMAN
A:
[1-289]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
-
L
T
G
E
V
V
A
L
K
K
I
R
---------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
-----
I
H
------
T
E
-----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
---
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
-
G
A
I
K
L
A
D
F
G
-----------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
TPDEVVWPGV
T
S
M
P
D
Y
K
-
P
S
-
F
P
K
W
-
A
---
R
Q
D
F
S
K
V
V
P
P
L
D
E
D
----------------
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
----------------------------------------------------------
67
PsiBlast_CBE
67.67
39%
-112
- C1 -
3EJ1
1
CDK2_HUMAN
C:
[1-289]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
-
L
T
G
E
V
V
A
L
K
K
I
R
L
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
-----
I
H
------
T
E
-----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
---
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
-
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
TPDEVVWPGV
T
S
M
P
D
Y
K
-
P
S
-
F
P
KW-
A
---
R
Q
D
F
S
K
V
V
P
P
L
D
E
D
----------------
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
-----------------------------------------------------------
84
PsiBlast_CBE
67.55
39%
-120
- C1 -
2VTQ
1
CDK2_HUMAN
A:
[1-289]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
-
L
T
G
E
V
V
A
L
K
K
I
R
----------
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
-----
I
H
------
T
E
-----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
---
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
-
G
A
I
K
L
A
D
F
G
----------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
TPDEVVWPGV
T
S
M
P
D
Y
K
-
P
S
-
F
P
K
W
-
A
---
R
Q
D
F
S
K
V
V
P
P
L
D
E
D
----------------
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
----------------------------------------------------------
63
PsiBlast_CBE
67.55
39%
-114
- C1 -
3F5X
2
CDK2_HUMAN
C:
[1-289]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
-
L
T
G
E
V
V
A
L
K
K
I
R
L
-
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
-----
I
H
------
T
E
-----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
---
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
-
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
TPDEVVWPGV
T
S
M
P
D
Y
K
-
P
S
-
F
P
KW-
A
---
R
Q
D
F
S
K
V
V
P
P
L
D
E
D
----------------
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
----------------------------------------------------------
73
PsiBlast_CBE
67.51
39%
-110
- C1 -
2X1N
1
CDK2_HUMAN
A:
[1-289]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
-
L
T
G
E
V
V
A
L
K
K
I
R
L
-
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
-----
I
H
------
T
E
-----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
---
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
-
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
TPDEVVWPGV
T
S
M
P
D
Y
K
-
P
S
-
F
P
K
W
-
A
---
R
Q
D
F
S
K
V
V
P
P
L
D
E
D
----------------
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
------------------------------------------------------------
6
PsiBlast_PDB
67.47
39%
-120
- C1 -
1OIT
1
CDK2_HUMAN
A:
[3-289]
--
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
-
L
-
G
E
V
V
A
L
K
K
I
------------
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
-----
I
H
------
T
E
-----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
---
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
S
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
-
G
A
I
K
L
A
D
F
G
L
A
R
A
------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
TPDEVVWPGV
T
S
M
P
D
Y
K
-
P
S
-
F
P
K
W
-
A
---
R
Q
D
F
S
K
V
V
P
P
L
D
E
D
----------------
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
----------------------------------------------------------
66
PsiBlast_CBE
67.44
39%
-111
- C1 -
3EOC
1
CDK2_HUMAN
A:
[1-289]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
-
L
T
G
E
V
V
A
L
K
K
I
R
L
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
-----
I
H
------
T
E
-----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
---
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
-
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
TPDEVVWPGV
T
S
M
P
D
Y
K
-
P
S
-
F
P
K
W
-
A
---
R
Q
D
F
S
K
V
V
P
P
L
D
E
D
----------------
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
----------------------------------------------------------
25
PsiBlast_CBE
67.37
39%
-115
- C1 -
5A14
2
?
A:
[2-290]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
-
L
T
G
E
V
V
A
L
K
K
I
R
L
-
D
--
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
-----
I
H
------
T
E
-----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
---
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
-
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-----------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
TPDEVVWPGV
T
S
M
P
D
Y
K
-
P
S
-
F
P
K
W
-
A
---
R
Q
D
F
S
K
V
V
P
P
L
D
E
D
----------------
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
------------------------------------------------------------
65
PsiBlast_CBE
67.29
39%
-112
- C1 -
3EOC
1
CDK2_HUMAN
C:
[1-289]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
-
L
T
G
E
V
V
A
L
K
K
I
R
L
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
-----
I
H
------
T
E
-----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
---
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
-
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
TPDEVVWPGV
T
S
M
P
D
Y
K
-
P
S
-
F
P
KW-
A
---
R
Q
D
F
S
K
V
V
P
P
L
D
E
D
----------------
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
------------------------------------------------------------
75
PsiBlast_CBE
67.23
39%
-112
- C1 -
2WEV
1
CDK2_HUMAN
A:
[1-289]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
-
L
T
G
E
V
V
A
L
K
K
I
R
L
-
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
-----
I
H
------
T
E
-----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
---
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
-
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
TPDEVVWPGV
T
S
M
P
D
Y
K
-
P
S
-
F
P
K
W
-
A
---
R
Q
D
F
S
K
V
V
P
P
L
D
E
D
----------------
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
------------------------------------------------------------
10
PsiBlast_PDB
66.42
39%
-110
- C1 -
1FIN
1
CDK2_HUMAN
A:
[1-289]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
-
L
T
G
E
V
V
A
L
K
K
I
R
L
-
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
-----
I
H
------
T
E
-----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
---
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
-
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
TPDEVVWPGV
T
S
M
P
D
Y
K
-
P
S
-
F
P
K
W
-
A
---
R
Q
D
F
S
K
V
V
P
P
L
D
E
D
----------------
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
----------------------------------------------------------
64
PsiBlast_CBE
66.07
39%
-114
- C1 -
3F5X
2
CDK2_HUMAN
A:
[1-289]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
-
L
T
G
E
V
V
A
L
K
K
I
R
L
-
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
-----
I
H
------
T
E
-----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
---
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
-
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
TPDEVVWPGV
T
S
M
P
D
Y
K
-
P
S
-
F
P
K
W
-
A
---
R
Q
D
F
S
K
V
V
P
P
L
D
E
D
----------------
G
R
S
L
L
S
Q
M
L
H
Y
D
P
-
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
----------------------------------------------------------
129
HHSearch
65.06
40%
-112
- C1 -
4AU8
2
CDK5_HUMAN
A:
[6-293]
-
Q
K
Y
E
K
L
E
K
I
G
E
G
T
Y
G
T
V
F
K
A
K
N
R
-
E
T
H
E
I
V
A
L
K
R
V
----------
P
S
S
A
L
R
E
I
C
L
L
K
E
L
K
H
K
N
I
V
R
L
H
D
V
-----
L
H
--------------
K
L
T
L
V
F
E
F
C
D
Q
D
L
K
K
Y
F
D
---
S
C
N
-
G
D
L
D
P
E
I
V
K
S
F
L
F
Q
L
L
K
G
L
G
F
C
H
S
R
N
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
R
N
-
G
E
L
K
L
A
D
F
G
L
A
R
A
F
G
-
I
P
V
R
--
S
A
E
V
V
T
L
W
Y
R
P
P
D
V
L
F
G
A
K
L
Y
S
T
S
I
D
M
W
S
A
G
C
I
F
A
E
L
A
N
A
G
R
P
L
F
P
G
N
D
V
D
D
Q
L
K
R
I
F
R
L
L
G
----------
T
P
T
E
E
Q
W
-
P
S
-
M
T
---
K
L--
P
D
Y
---
K
P
Y
P
M
Y
P
A
T
T
S
L
V
N
V
V
P
-
K
L
-
N
A
T
G
R
D
L
L
Q
N
L
L
K
C
N
P
V
Q
R
I
S
A
E
E
A
L
Q
H
P
Y
F
S
D
F
-------------------------------------------------------------------
125
HHSearch
64.65
33%
-123
- C1 -
2B9H
1
FUS3_YEAST
A:
[11-314]
-
S
D
F
Q
L
K
S
L
L
G
E
G
A
Y
G
V
V
C
S
A
T
H
K
-
P
T
G
E
I
V
A
I
K
K
I
E
--
P
F
D
K
P
L
F
A
L
R
T
L
R
E
I
K
I
L
K
H
F
K
H
E
N
I
I
T
I
F
N
I
QRPDS
F
E
------
N
F
-----
N
E
V
Y
I
I
Q
E
L
M
Q
T
D
L
H
R
V
I
S
---
T
---
Q
M
L
S
D
D
H
I
Q
Y
F
I
Y
Q
T
L
R
A
V
K
V
L
H
G
S
N
V
I
H
R
D
L
K
P
S
N
L
L
I
N
S
N
-
C
D
L
K
V
C
D
F
G
L
A
R
I
I
D
-------
V
E
F
V
A
T
R
W
Y
R
A
P
E
V
M
L
T
S
A
K
Y
S
R
A
M
D
V
W
S
C
G
C
I
L
A
E
L
F
L
-
R
R
P
I
F
P
G
R
D
Y
R
H
Q
L
L
L
I
F
G
I
I
G
----------
T
P
H
S
D
N
D
-
L
R
C
I
E
S
P
R
A
---
R
E
Y
I
K
--
S
L
P
M
Y
-
P
A
A
P
L
E
K
M
F
P
-
R
V
-
N
P
K
G
I
D
L
L
Q
R
M
L
V
F
D
P
A
K
R
I
T
A
K
E
A
L
E
H
P
Y
L
Q
T
Y
H
D
P
N
D
E
P
E
G
E
P
I
P
P
S
F
F
E
F
D
H
Y
K
E
A
L
T
T
K
D
L
K
K
L
I
W
N
E
I
F
S
--------------------------
130
HHSearch
64.44
31%
-106
- C1 -
4QNY
1
?
A:
[20-317]
-
D
R
Y
L
L
E
R
I
I
G
A
G
S
Y
G
V
V
I
R
A
R
D
T
K
S
D
N
R
L
V
A
M
K
R
V
N
K
E
I
F
E
E
V
I
L
A
K
R
I
L
R
E
I
K
L
L
A
H
F
N
D
D
N
I
I
G
L
R
N
I
-----
L
T
------
P
E
DPENF
D
H
F
Y
I
V
M
D
I
M
E
T
D
L
K
Q
V
L
R
---
S
-
G
-
Q
E
L
T
E
A
H
I
Q
F
F
I
Y
Q
A
L
R
A
L
H
I
I
H
S
A
G
V
I
H
R
D
I
T
P
A
N
I
L
V
N
T
N
-
C
D
L
K
I
C
D
F
G
L
A
K
E
E
----
G
E
Y
M
T
D
Y
V
T
M
R
W
Y
R
A
P
E
L
V
M
E
D
K
D
Y
S
A
Q
I
D
V
W
G
I
G
C
I
L
G
E
L
L
G
-
S
R
P
L
F
Q
G
K
D
R
V
N
Q
L
D
K
I
V
D
V
I
G
----------
T
P
S
E
E
D
I
-
N
S
-
V
G
---
S
S
A
A
Q
K
Y
L
K
K
K
S
---
H
R
P
Q
A
D
W
R
Q
R
Y
P
-
T
A
-
S
P
E
A
L
D
L
L
R
H
M
L
V
F
N
P
K
R
R
I
T
V
L
Q
A
M
R
H
P
F
L
E
Q
L
H
D
D
Y
A
L
F
R
F
D
T
I
V
D
V
K
R
A
I
Y
E
E
S
V
K
F
-----------------------------------------
24
PsiBlast_CBE
64.10
39%
-121
- C1 -
5D1J
1
?
A:
[1-289]
M
E
N
F
Q
K
V
E
K
I
G
E
--
Y
G
V
V
Y
K
A
R
N
K
-
L
T
G
E
V
V
A
L
K
K
I
R
---------------
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
-----
I
H
------
T
E
-----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
---
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
-
G
A
I
K
L
A
D
F
------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
TPDEVVWPGV
T
S
M
P
D
Y
K
-
P
S
-
F
P
K
W
-
A
---
R
Q
D
F
S
K
V
V
P
P
L
D
E
D
----------------
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
----------------------------------------------------------
115
HHSearch
62.83
39%
-109
- C1 -
1UA2
1
CDK7_HUMAN
A:
[13-298]
----
E
K
L
D
F
L
G
E
G
Q
F
A
T
V
Y
K
A
R
D
K
-
N
T
N
Q
I
V
A
I
K
K
I
----------
N
R
T
A
L
R
E
I
K
L
L
Q
E
L
S
H
P
N
I
I
G
L
L
D
A
-----
F
G
------
H
K
-----
S
N
I
S
L
V
F
D
F
M
E
T
D
L
E
V
I
I
K
---
D
N
S
-
L
V
L
T
P
S
H
I
K
A
Y
M
L
M
T
L
Q
G
L
E
Y
L
H
Q
H
W
I
L
H
R
D
L
K
P
N
N
L
L
L
D
E
N
-
G
V
L
K
L
A
D
F
G
L
A
K
S
F
G
-
S
P
N
R
A
Y
T
H
Q
V
V
T
R
W
Y
R
A
P
E
L
L
F
G
A
R
M
Y
G
V
G
V
D
M
W
A
V
G
C
I
L
A
E
L
L
L
-
R
V
P
F
L
P
G
D
S
D
L
D
Q
L
T
R
I
F
E
T
L
G
----------
T
P
T
E
E
Q
W
P
D
M
-
C
S
---
L
---
P
D
Y
V
T
F
K
S
F
P
----
G
I
P
L
H
H
I
F
S
-
A
A
-
G
D
D
L
L
D
L
I
Q
G
L
F
L
F
N
P
C
A
R
I
T
A
T
Q
A
L
K
M
K
Y
F
S
N
R
P
G
P
T
P
G
C
Q
L
P
R
P
N
------------------------------------------------------
126
HHSearch
62.56
37%
-116
- C1 -
1J1B
1
GSK3B_HUMAN
A:
[55-346]
--
S
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
C
-
D
S
G
E
L
V
A
I
K
K
V
L
Q
-
D
K
R
------
F
K
N
R
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
L
R
Y
F
-----
F
Y
S
S
GEKK
D
E
-----
V
Y
L
N
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
H
Y
S
R
A
K
-
Q
T
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
D
P
D
T
A
V
L
K
L
C
D
F
G
S
A
K
Q
L
V
--
R
G
E
P
N
V
S
Y
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
-
G
Q
P
I
F
P
G
D
S
G
V
D
Q
L
V
E
I
I
K
V
L
G
----------
T
--
P
T
R
E
-
Q
I
-
R
E
---
M
---
N
P
N
Y
T
E
F
K
F
P
Q
I
K
-
A
H
P
W
T
K
V
F
R
P
R
T
-
P
P
E
A
I
A
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
D
P
N
V
K
L
P
N
G
R
D
T
P
A
L
F
N
F
T
T
Q
E
L
S
S
N
P
P
L
A
T
I
L
I
P
P
H
A
R
I
Q
A
A
A
----------------------
42
PsiBlast_CBE
44.13
39%
-6
- C1 -
4EK4
1
CDK2_HUMAN
A:
[4-290]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
-
L
T
G
E
V
V
A
L
K
K
I
----------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
-----
I
H
------
T
E
-----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
---
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
-
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
TPDEVVWPGV
T
S
M
P
D
Y
K
-
P
S
-
F
P
K
W
-
A
---
R
Q
D
F
S
K
V
V
P
P
L
D
E
D
----------------
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
------------------------------------------------------------
80
PsiBlast_CBE
37.84
39%
-10
- C1 -
2VV9
1
CDK2_HUMAN
A:
[4-290]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
-
L
T
G
E
V
V
A
L
K
K
I
R
L
-------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
-----
I
H
------
T
E
-----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
---
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
-
G
A
I
K
L
A
D
F
G
L
A
--------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
TPDEVVWPGV
T
S
M
P
D
Y
K
-
P
S
-
F
P
K
W
-
A
---
R
Q
D
F
S
K
V
V
P
P
L
D
E
D
----------------
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
----------------------------------------------------------
41
PsiBlast_CBE
37.44
39%
-12
- C1 -
4EK5
1
CDK2_HUMAN
A:
[4-290]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
-
L
T
G
E
V
V
A
L
K
K
I
----------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
-----
I
H
------
T
E
-----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
---
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
-
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
TPDEVVWPGV
T
S
M
P
D
Y
K
-
P
S
-
F
P
K
W
-
A
---
R
Q
D
F
S
K
V
V
P
P
L
D
E
D
----------------
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
----------------------------------------------------------
77
PsiBlast_CBE
37.21
39%
-10
- C1 -
2W17
1
CDK2_HUMAN
A:
[4-290]
M
E
N
F
Q
K
V
E
K
I
G
E
-
T
Y
G
V
V
Y
K
A
R
N
K
-
L
T
G
E
V
V
A
L
K
K
I
R
L
-
D
-----
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
-----
I
H
------
T
E
------
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
---
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
-
G
A
I
K
L
A
D
F
G
L
A
--------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
TPDEVVWPGV
T
S
M
P
D
Y
K
-
P
S
-
F
P
K
W
-
A
---
R
Q
D
F
S
K
V
V
P
P
L
D
E
D
----------------
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
----------------------------------------------------------
35
PsiBlast_CBE
37.20
39%
-7
- C1 -
4FKO
1
CDK2_HUMAN
A:
[4-290]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
-
L
T
G
E
V
V
A
L
K
K
I
R
L
--------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
-----
I
H
------
T
E
-----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
---
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
-
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
TPDEVVWPGV
T
S
M
P
D
Y
K
-
P
S
-
F
P
K
W
-
A
---
R
Q
D
F
S
K
V
V
P
P
L
D
E
D
----------------
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
----------------------------------------------------------
31
PsiBlast_CBE
36.86
39%
-12
- C1 -
4FKV
2
CDK2_HUMAN
A:
[4-290]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
-
L
T
G
E
V
V
A
L
K
K
I
R
L
------
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
-----
I
H
------
T
E
-----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
---
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
-
G
A
I
K
L
A
D
F
G
L
A
R
------------
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
TPDEVVWPGV
T
S
M
P
D
Y
K
-
P
S
-
F
P
K
W
-
A
---
R
Q
D
F
S
K
V
V
P
P
L
D
E
D
----------------
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
----------------------------------------------------------
33
PsiBlast_CBE
36.80
39%
-12
- C1 -
4FKQ
2
CDK2_HUMAN
A:
[4-290]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
-
L
T
G
E
V
V
A
L
K
K
I
R
L
-------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
-----
I
H
------
T
E
-----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
---
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
-
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
----------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
TPDEVVWPGV
T
S
M
P
D
Y
K
-
P
S
-
F
P
K
W
-
A
---
R
Q
D
F
S
K
V
V
P
P
L
D
E
D
----------------
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
----------------------------------------------------------
38
PsiBlast_CBE
36.62
39%
-9
- C1 -
4FKG
1
CDK2_HUMAN
A:
[4-290]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
-
L
T
G
E
V
V
A
L
K
K
I
----------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
-----
I
H
------
T
E
-----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
---
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
-
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
----
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
TPDEVVWPGV
T
S
M
P
D
Y
K
-
P
S
-
F
P
K
W
-
A
---
R
Q
D
F
S
K
V
V
P
P
L
D
E
D
----------------
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
----------------------------------------------------------
60
PsiBlast_CBE
35.84
39%
-9
- C1 -
3IGG
1
CDK2_HUMAN
A:
[4-290]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
-
L
T
G
E
V
V
A
L
K
K
I
---------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
-----
I
H
------
T
E
-----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
---
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
-
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
TPDEVVWPGV
T
S
M
P
D
Y
K
-
P
S
-
F
P
K
W
-
A
---
R
Q
D
F
S
K
V
V
P
P
L
D
E
D
----------------
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
----------------------------------------------------------
53
PsiBlast_CBE
35.73
39%
-12
- C1 -
3SW7
1
CDK2_HUMAN
A:
[4-290]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
-
L
T
G
E
V
V
A
L
K
K
I
R
L
--------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
-----
I
H
------
T
E
-----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
---
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
-
G
A
I
K
L
A
D
F
G
L
A
--------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
TPDEVVWPGV
T
S
M
P
D
Y
K
-
P
S
-
F
P
K
W
-
A
---
R
Q
D
F
S
K
V
V
P
P
L
D
E
D
----------------
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
----------------------------------------------------------
37
PsiBlast_CBE
35.48
39%
-11
- C1 -
4FKJ
1
CDK2_HUMAN
A:
[4-290]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
-
L
T
G
E
V
V
A
L
K
K
I
----------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
-----
I
H
------
T
E
-----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
---
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
-
G
A
I
K
L
A
D
F
G
L
A
R
A
------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
TPDEVVWPGV
T
S
M
P
D
Y
K
-
P
S
-
F
P
K
W
-
A
---
R
Q
D
F
S
K
V
V
P
P
L
D
E
D
----------------
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
----------------------------------------------------------
32
PsiBlast_CBE
35.15
39%
-11
- C1 -
4FKR
2
CDK2_HUMAN
A:
[4-290]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
-
L
T
G
E
V
V
A
L
K
K
I
R
L
--------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
-----
I
H
------
T
E
-----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
---
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
-
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
----------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
TPDEVVWPGV
T
S
M
P
D
Y
K
-
P
S
-
F
P
K
W
-
A
---
R
Q
D
F
S
K
V
V
P
P
L
D
E
D
----------------
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
----------------------------------------------------------
40
PsiBlast_CBE
35.06
39%
-15
- C1 -
4EK6
1
CDK2_HUMAN
A:
[4-290]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
-
L
T
G
E
V
V
A
L
K
K
I
-----------
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
-----
I
H
------
T
E
-----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
---
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
-
G
A
I
K
L
A
D
F
G
L
A
R
A
-----------
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
TPDEVVWPGV
T
S
M
P
D
Y
K
-
P
S
-
F
P
K
W
-
A
---
R
Q
D
F
S
K
V
V
P
P
L
D
E
D
----------------
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
----------------------------------------------------------
30
PsiBlast_CBE
34.51
39%
-8
- C1 -
4FKW
2
CDK2_HUMAN
A:
[4-290]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
-
L
T
G
E
V
V
A
L
K
K
I
R
L
------
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
-----
I
H
------
T
E
-----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
---
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
-
G
A
I
K
L
A
D
F
G
L
A
--------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
TPDEVVWPGV
T
S
M
P
D
Y
K
-
P
S
-
F
P
K
W
-
A
---
R
Q
D
F
S
K
V
V
P
P
L
D
E
D
----------------
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
----------------------------------------------------------
61
PsiBlast_CBE
34.23
39%
-6
- C1 -
3IG7
1
CDK2_HUMAN
A:
[4-290]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
-
L
T
G
E
V
V
A
L
K
K
I
---------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
-----
I
H
------
T
E
-----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
---
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
-
G
A
I
K
L
A
D
F
G
L
A
R
A
F
-------------
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
TPDEVVWPGV
T
S
M
P
D
Y
K
-
P
S
-
F
P
K
W
-
A
---
R
Q
D
F
S
K
V
V
P
P
L
D
E
D
----------------
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
----------------------------------------------------------