@TOME V2.3
(Nov 2016)

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3D Common Core:

Structural Clustering:

Modeller Result :

Complexes Modeling
Templates Information:
Sequence & Result Tab:

Values color: [ Good | Correct | Middling | Bad ]Sequence color : MutatedHelixStrandConserved

Query sequence : CDKL2_HUMAN: (2015-10-05 )
MEKYENLGLVGEGSYGMVMKCRNKDTGRIVAIKKFLESDDDKMVKKIAMREIKLLKQLRHENLVNLLEVCKKKKRWYLVFEFVDHTILDDLELFPNGLDYQVVQKYLFQIINGIGFCHSHNIIHRDIKPENILVSQSGVVKLCDFGFARTLAAPGEVYTDYVATRWYRAPELLVGDVKYGKAVDVWAIGCLVTEMFMGEPLFPGDSDIDQLYHIMMCLGNLIPRHQELFNKNPVFAGVRLPEIKEREPLERRYPKLSEVVIDLAKKCLHIDPDKRPFCAELLHHDFFQMDGFAERFSQELQLKVQKDARNVSLSKKSQNRKKEKEKDDSLVEERKTLVVQDTNADPKIKDYKLFKIKGSKIDGEKAEKGNRASNASCLHDSRTSHNKIVPSTSLKDCSNVSVDHTRNPSVAIPPLTHNLSAVAPSINSGMGTETIPIQGYRVDEKTKKCSIPFVKPNRHSPSGIYNINVTTLVSGPPLSDDSGADLPQMEHQH

Atome Classification :

(102 SA) .........10........20...-.....30.......-.40........50........60........70..------.------.....80......---..90....-....100.......110.......120.......130.......140.......150.......160.......170.......180.......190.....-..200.......210.......220..--------.....230--........-.240..------...--..250...-....260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.
(Atome) (Ident) (Tito) (Num) (Ligand) (Uniprot) MEKYENLGLVGEGSYGMVMKCRNK-DTGRIVAIKKFLES-DDDKMVKKIAMREIKLLKQLRHENLVNLLEVCKKK------K------RWYLVFEFVDHTI---LDDLELFP-NGLDYQVVQKYLFQIINGIGFCHSHNIIHRDIKPENILVSQSGVVKLCDFGFARTLAAPGEVYTDYVATRWYRAPELLVGDVKYGKAVDVWAIGCLVTEMFM-GEPLFPGDSDIDQLYHIMMCLGNLIPR--------HQELFN----KNPVFAGV-RLPEIK------ERE--PLERRYPK-LSEVVIDLAKKCLHIDPDKRPFCAELLHHDFFQMDGFAERFSQELQLKVQKDARNVSLSKKSQNRKKEKEKDDSLVEERKTLVVQDTNADPKIKDYKLFKIKGSKIDGEKAEKGNRASNASCLHDSRTSHNKIVPSTSLKDCSNVSVDHTRNPSVAIPPLTHNLSAVAPSINSGMGTETIPIQGYRVDEKTKKCSIPFVKPNRHSPSGIYNINVTTLVSGPPLSDDSGADLPQMEHQH
111 HHSearch 94.2999%-149 - C2 -4AAA CDKL2_HUMAN A:[24-325] MEKYENLGLVGEGSYGMVMKCRNK-DTGRIVAIKKFLES-DDDKMVKKIAMREIKLLKQLRHENLVNLLEVCKKK------K------RWYLVFEFVDHTI---LDDLELFP-NGLDYQVVQKYLFQIINGIGFCHSHNIIHRDIKPENILVSQSGVVKLCDFGFA------------EVATRWYRAPELLVGDVKYGKAVDVWAIGCLVTEMFM-GEPLFPGDSDIDQLYHIMMCLGNLIPR--------HQELFN----KNPVFAGV-RLPEIK------ERE--PLERRYPK-LSEVVIDLAKKCLHIDPDKRPFCAELLHHDFFQMDGFAERFSQELQL-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1 PsiBlast_PDB 94.2999%-149 - C2 -4AAA CDKL2_HUMAN A:[24-325] MEKYENLGLVGEGSYGMVMKCRNK-DTGRIVAIKKFLES-DDDKMVKKIAMREIKLLKQLRHENLVNLLEVCKKK------K------RWYLVFEFVDHTI---LDDLELFP-NGLDYQVVQKYLFQIINGIGFCHSHNIIHRDIKPENILVSQSGVVKLCDFGFA------------EVATRWYRAPELLVGDVKYGKAVDVWAIGCLVTEMFM-GEPLFPGDSDIDQLYHIMMCLGNLIPR--------HQELFN----KNPVFAGV-RLPEIK------ERE--PLERRYPK-LSEVVIDLAKKCLHIDPDKRPFCAELLHHDFFQMDGFAERFSQELQL-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2 PsiBlast_PDB 93.4999%-140 - C2 -4BBM CDKL2_HUMAN A:[24-331] MEKYENLGLVG--SYGMVMKCRNK-DTGRIVAIKKFLES-DDDKMVKKIAMREIKLLKQLRHENLVNLLEVCKKK------K------RWYLVFEFVDHTI---LDDLELFP-NGLDYQVVQKYLFQIINGIGFCHSHNIIHRDIKPENILVSQSGVVKLCDFGFARTLAAPGEVYDDEVATRWYRAPELLVGDVKYGKAVDVWAIGCLVTEMFM-GEPLFPGDSDIDQLYHIMMCLGNLIPR--------HQELFN----KNPVFAGV-RLPEIK------ERE--PLERRYPK-LSEVVIDLAKKCLHIDPDKRPFCAELLHHDFFQMDGFAERFSQELQLKVQKDA-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21 PsiBlast_CBE 92.3799%-143 - C2 -4BBM CDKL2_HUMAN B:[24-331] MEKYENLG-----SYGMVMKCRNK-DTGRIVAIKKF----------KKIAMREIKLLKQLRHENLVNLLEVC------------------YLVFEFVDHTI---LDDLELFP-NGLDYQVVQKYLFQIINGIGFCHSHNIIHRDIKPENILVSQSGVVKLCDFGFARTLAAPGEVYDDEVATRWYRAPELLVGDVKYGKAVDVWAIGCLVTEMFM-GEPLFPGDSDIDQLYHIMMCLGNLIPR--------HQELFN----KNPVFAGV-RLPEIK------ERE--PLERRYPK-LSEVVIDLAKKCLHIDPDKRPFCAELLHHDFFQMDGFAERFSQELQLKVQKDA-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
112 HHSearch 81.1857%-123 - C2 -3ZDU CDKL3_HUMAN A:[2-310] MEMYETLGKVGEGSYGTVMKCKHK-NTGQIVAIKIFY---------NKIAMREIKFLKQFHHENLVNLIEVFRQK------K------KIHLVFEFIDHTV---LDELQHYC-HGLESKRLRKYLFQILRAIDYLHSNNIIHRDIKPENILVSQSGITKLCDFGFART-----DIYDDEVATRWYRAPELVLKDTSYGKPVDIWALGCMIIEMAT-GNPYLPSSSDLDLLHKIVLKVGNLSPH--------LQNIFS----KSPIFAGV-VLPQVQ------HPK--NARKKYPK-LNGLLADIVHACLQIDPADRISSSDLLHHEYFTRDGFIEKFMPELKAKLLQEAKV---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3 PsiBlast_PDB 80.9256%-123 - C2 -3ZDU CDKL3_HUMAN A:[2-310] MEMYETLGKVGEGSYGTVMKCKHK-NTGQIVAIKIFY---------NKIAMREIKFLKQFHHENLVNLIEVFRQK------K------KIHLVFEFIDHTV---LDELQHYC-HGLESKRLRKYLFQILRAIDYLHSNNIIHRDIKPENILVSQSGITKLCDFGFART-----DIYDDEVATRWYRAPELVLKDTSYGKPVDIWALGCMIIEMAT-GNPYLPSSSDLDLLHKIVLKVGNLSPH--------LQNIFS----KSPIFAGV-VLPQVQ------HPK--NARKKYPK-LNGLLADIVHACLQIDPADRISSSDLLHHEYFTRDGFIEKFMPELKAKLLQEAKV---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
113 HHSearch 77.3456%-132 - C2 -4AGU CDKL1_HUMAN A:[3-292] -EKYEKIGKIGEGSYGVVFKCRNR-DTGQIVAIKKFLES-ED-PVIKKIALREIRMLKQLKHPNLVNLLEVFRRK------R------RLHLVFEYCDHTV---LHELDRYQ-RGVPEHLVKSITWQTLQAVNFCHKHNCIHRDVKPENILITKHSVIKLCDFGFARLLT------------RWYRSPELLVGDTQYGPPVDVWAIGCVFAELLS-GVPLWPGKSDVDQLYLIRKTLGDLIPR--------HQQVFS----TNQYFSGV-KIPDPE------DME--PLELKFPN-ISYPALGLLKGCLHMDPTERLTCEQLLHHPYFENIR----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4 PsiBlast_PDB 77.1657%-133 - C2 -4AGU CDKL1_HUMAN A:[3-289] -EKYEKIGKIGEGSYGVVFKCRNR-DTGQIVAIKKFLES-ED-PVIKKIALREIRMLKQLKHPNLVNLLEVFRRK------R------RLHLVFEYCDHTV---LHELDRYQ-RGVPEHLVKSITWQTLQAVNFCHKHNCIHRDVKPENILITKHSVIKLCDFGFARLLT------------RWYRSPELLVGDTQYGPPVDVWAIGCVFAELLS-GVPLWPGKSDVDQLYLIRKTLGDLIPR--------HQQVFS----TNQYFSGV-KIPDPE------DME--PLELKFPN-ISYPALGLLKGCLHMDPTERLTCEQLLHHPYFENIR----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23 PsiBlast_CBE 76.7657%-136 - C2 -4AGU CDKL1_HUMAN B:[4-289] --KYEKIGKIGEGSYGVVFKCRNR-DTGQIVAIKKFLES---DPVIKKIALREIRMLKQLKHPNLVNLLEVFRRK------R------RLHLVFEYCDHTV---LHELDRYQ-RGVPEHLVKSITWQTLQAVNFCHKHNCIHRDVKPENILITKHSVIKLCDFGFARLLT------------RWYRSPELLVGDTQYGPPVDVWAIGCVFAELLS-GVPLWPGKSDVDQLYLIRKTLGDLIPR--------HQQVFS----TNQYFSGV-KIPDPE------DME--PLELKFPN-ISYPALGLLKGCLHMDPTERLTCEQLLHHPYFENIRE---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22 PsiBlast_CBE 76.3457%-134 - C2 -4AGU CDKL1_HUMAN C:[3-289] -EKYEKIGKIGEGSYGVVFKCRNR-DTGQIVAIKKFLES-EDDPVIKKIALREIRMLKQLKHPNLVNLLEVFRRK------R------RLHLVFEYCDHTV---LHELDRYQ-RGVPEHLVKSITWQTLQAVNFCHKHNCIHRDVKPENILITKHSVIKLCDFGFARLLT------------RWYRSPELLVGDTQYGPPVDVWAIGCVFAELLS-GVPLWPGKSDVDQLYLIRKTLGDLIPR--------HQQVFS----TNQYFSGV-KIPDPE------DME--PLELKFPN-ISYPALGLLKGCLHMDPTERLTCEQLLHHPYFENIR----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
114 HHSearch 72.0349%-141 - C2 -4BGQ CDKL5_HUMAN A:[11-301] MNKFEILGVVGEGAYGVVLKCRHK-ETHEIVAIKKFK--------VKETTLRELKMLRTLKQENIVELKEAFRRR------G------KLYLVFEYVEKNM---LELLEEMP-NGVPPEKVKSYIYQLIKAIHWCHKNDIVHRDIKPENLLISHNDVLKLCDFGFARNLSE----------TRWYRSPELLLG-APYGKSVDMWSVGCILGELSD-GQPLFPGESEIDQLFTIQKVLGPLPSE--------QMKLFY----SNPRFHGL-RFPAVN------HPQ--SLERRYLGILNSVLLDLMKNLLKLDPADRYLTEQCLNHPTFQTQRL---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5 PsiBlast_PDB 71.6148%-142 - C2 -4BGQ CDKL5_HUMAN A:[11-299] MNKFEILGVVGEGAYGVVLKCRHK-ETHEIVAIKKFK--------VKETTLRELKMLRTLKQENIVELKEAFRRR------G------KLYLVFEYVEKNM---LELLEEMP-NGVPPEKVKSYIYQLIKAIHWCHKNDIVHRDIKPENLLISHNDVLKLCDFGFARNLSE----------TRWYRSPELLLG-APYGKSVDMWSVGCILGELSD-GQPLFPGESEIDQLFTIQKVLGPLPSE--------QMKLFY----SNPRFHGL-RFPAVN------HPQ--SLERRYLGILNSVLLDLMKNLLKLDPADRYLTEQCLNHPTFQTQRL---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
59 PsiBlast_CBE 70.0041%-133 - C2 -3LFN CDK2_HUMAN A:[1-287] MENFQKVEKIGEGTYGVVYKARNK-LTGEVVALKKIR-----TEGVPSTAIREISLLKELNHPNIVKLLDVIHTE------N------KLYLVFEFLHQDLKKFMDASAL---TGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARA---------HEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVT-RRALFPGDSEIDQLFRIFRTLGT-----------------P----DEVVWPGVTSMPDYKPSFPKWARQ--DFSKVVPP-LDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11 PsiBlast_PDB 69.5541%-131 - C2 -1DI8 CDK2_HUMAN A:[1-287] MENFQKVEKIGEGTYGVVYKARNK-LTGEVVALKKIR-------GVPSTAIREISLLKELNHPNIVKLLDVIHTE------N------KLYLVFEFLHQDLKKFMDASAL---TGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAF---------EVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVT-RRALFPGDSEIDQLFRIFRTLGT-----------------P----DEVVWPGVTSMPDYKPSFPKWARQ--DFSKVVPP-LDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6 PsiBlast_PDB 69.5341%-121 - C2 -4EOI CDK2_HUMAN A:[2-288] MENFQKVEKIGEGTYGVVYKARNK-LTGEVVALKKIRL-----EGVPSTAIREISLLKELNHPNIVKLLDVIHTE------N------KLYLVFEFLHQDL---KDFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPENLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVT-RRALFPGDSEIDQLFRIFRTLGT-----------------P----DEVVWPGVTSMPDYKPSFPKWARQ--DFSKVVPP-LDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27 PsiBlast_CBE 69.4941%-123 - C2 -4KD1 CDK2_HUMAN A:[1-287] MENFQKVEKIGEGTYGVVYKARNK-LTGEVVALKKIRLD-TETEGVPSTAIREISLLKELNHPNIVKLLDVIHTE------N------KLYLVFEFLHQDLKKFMDASAL---TGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVT-RRALFPGDSEIDQLFRIFRTLGT-----------------P----DEVVWPGVTSMPDYKPSFPKWARQ--DFSKVVPP-LDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
50 PsiBlast_CBE 69.3941%-131 - C2 -3TIZ CDK2_HUMAN A:[2-287] -ENFQKVEKIGEGTYGVVYKARNK-LTGEVVALKKIR-----TEGVPSTAIREISLLKELNHPNIVKLLDVIHTE------N------KLYLVFEFLHQDLKKFMDASAL---TGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVT-RRALFPGDSEIDQLFRIFRTLGT-----------------P----DEVVWPGVTSMPDYKPSFPKWARQ--DFSKVVPP-LDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
99 PsiBlast_CBE 69.3741%-135 - C2 -2R64 CDK2_HUMAN A:[1-287] MENFQKVEKIGEGTYGVVYKARNK-LTGEVVALKKI---------VPSTAIREISLLKELNHPNIVKLLDVIHTE------N------KLYLVFEFLHQDLKKFMDASAL---TGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAF-----------VTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVT-RRALFPGDSEIDQLFRIFRTLGT-----------------P----DEVVWPGVTSMPDYKPSFPKWARQ--DFSKVVPP-LDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
20 PsiBlast_PDB 69.3441%-131 - C2 -1KE6 CDK2_HUMAN A:[1-287] MENFQKVEKIGEGTYGVVYKARNK-LTGEVVALKKIR--------VPSTAIREISLLKELNHPNIVKLLDVIHTE------N------KLYLVFEFLHQDLKKFMDASAL---TGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAF-----------VTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVT-RRALFPGDSEIDQLFRIFRTLGT-----------------P----DEVVWPGVTSMPDYKPSFPKWARQ--DFSKVVPP-LDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26 PsiBlast_CBE 69.1341%-125 - C2 -4LYN CDK2_HUMAN A:[1-287] MENFQKVEKIGEGTYGVVYKARNK-LTGEVVALKKIRLD-TETEGVPSTAIREISLLKELNHPNIVKLLDVIHTE------N------KLYLVFEFLHQDLKKFMDASAL---TGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAF-----------VTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVT-RRALFPGDSEIDQLFRIFRTLGT-----------------P----DEVVWPGVTSMPDYKPSFPKWARQ--DFSKVVPP-LDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
71 PsiBlast_CBE 69.0841%-124 - C2 -2XMY CDK2_HUMAN A:[1-287] MENFQKVEKIGEGTYGVVYKARNK-LTGEVVALKKIRLD-T---GVPSTAIREISLLKELNHPNIVKLLDVIHTE------N------KLYLVFEFLHQDLKKFMDASAL---TGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVT-RRALFPGDSEIDQLFRIFRTLGT-----------------P----DEVVWPGVTSMPDYKPSFPKWARQ--DFSKVVPP-LDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
94 PsiBlast_CBE 69.0241%-126 - C2 -2V0D CDK2_HUMAN A:[1-287] MENFQKVEKIGEGTYGVVYKARNK-LTGEVVALKKIRL-------VPSTAIREISLLKELNHPNIVKLLDVIHTE------N------KLYLVFEFLHQDLKKFMDASAL---TGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVT-RRALFPGDSEIDQLFRIFRTLGT-----------------P----DEVVWPGVTSMPDYKPSFPKWARQ--DFSKVVPP-LDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
48 PsiBlast_CBE 69.0141%-126 - C2 -3UNJ CDK2_HUMAN A:[1-287] MENFQKVEKIGEGTYGVVYKARNK-LTGEVVALKKIR-----TEGVPSTAIREISLLKELNHPNIVKLLDVIHTE------N------KLYLVFEFLHQDLKKFMDASAL---TGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVT-RRALFPGDSEIDQLFRIFRTLGT-----------------P----DEVVWPGVTSMPDYKPSFPKWARQ--DFSKVVPP-LDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
97 PsiBlast_CBE 68.8841%-123 - C2 -2UUE CDK2_HUMAN C:[1-287] MENFQKVEKIGEGTYGVVYKARNK-LTGEVVALKKIRLD-TETEGVPSTAIREISLLKELNHPNIVKLLDVIHTE------N------KLYLVFEFLHQDLKKFMDASAL---TGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVT-RRALFPGDSEIDQLFRIFRTLGT-----------------P----DEVVWPGVTSMPDYKPSFPKWARQ--DFSKVVPP-LDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLR---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10 PsiBlast_PDB 68.8141%-136 - C2 -1CKP CDK2_HUMAN A:[1-287] MENFQKVEKIGEGTYGVVYKARNK-LTGEVVALKKI---------VPSTAIREISLLKELNHPNIVKLLDVIHTE------N------KLYLVFEFLHQDLKKFMDASAL---TGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAF-----------VTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVT-RRALFPGDSEIDQLFRIFRTLGT-----------------P----DEVVWPGVTSMPDYKPSFPKWARQ--DFSKVVPP-LDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
76 PsiBlast_CBE 68.7941%-128 - C2 -2W1H CDK2_HUMAN A:[1-287] MENFQKVEKIGEGTYGVVYKARNK-LTGEVVALKKIR-----TEGVPSTAIREISLLKELNHPNIVKLLDVIHTE------N------KLYLVFEFLHQDLKKFMDASAL---TGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAF-----------VTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVT-RRALFPGDSEIDQLFRIFRTLGT-----------------P----DEVVWPGVTSMPDYKPSFPKWARQ--DFSKVVPP-LDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
72 PsiBlast_CBE 68.7941%-122 - C2 -2X1N CDK2_HUMAN C:[1-287] MENFQKVEKIGEGTYGVVYKARNK-LTGEVVALKKIRLD-TETEGVPSTAIREISLLKELNHPNIVKLLDVIHTE------N------KLYLVFEFLHQDLKKFMDASAL---TGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVT-RRALFPGDSEIDQLFRIFRTLGT-----------------P----DEVVWPGVTSMPDYKPSFPKWARQ--DFSKVVPP-LDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLR---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14 PsiBlast_PDB 68.7541%-122 - C2 -1FVV CDK2_HUMAN A:[1-287] MENFQKVEKIGEGTYGVVYKARNK-LTGEVVALKKIRLD-TETEGVPSTAIREISLLKELNHPNIVKLLDVIHTE------N------KLYLVFEFLHQDLKKFMDASAL---TGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVT-RRALFPGDSEIDQLFRIFRTLGT-----------------P----DEVVWPGVTSMPDYKPSFPKWARQ--DFSKVVPP-LDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13 PsiBlast_PDB 68.7141%-133 - C2 -1FVT CDK2_HUMAN A:[1-287] MENFQKVEKIGEGTYGVVYKARNK-LTGEVVALKKIR--------VPSTAIREISLLKELNHPNIVKLLDVIHTE------N------KLYLVFEFLHQDLKKFMDASAL---TGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFG---------VVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVT-RRALFPGDSEIDQLFRIFRTLGT-----------------P----DEVVWPGVTSMPDYKPSFPKWARQ--DFSKVVPP-LDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
29 PsiBlast_CBE 68.6441%-125 - C2 -4FX3 CDK2_HUMAN A:[1-287] MENFQKVEKIGEGTYGVVYKARNK-LTGEVVALKKIRLD-TETEGVPSTAIREISLLKELNHPNIVKLLDVIHTE------N------KLYLVFEFLHQDLKKFMDASAL---TGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVT-RRALFPGDSEIDQLFRIFRTLGT-----------------P----DEVVWPGVTSMPDYKPSFPKWARQ--DFSKVVPP-LDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28 PsiBlast_CBE 68.5941%-122 - C2 -4FX3 CDK2_HUMAN C:[1-287] MENFQKVEKIGEGTYGVVYKARNK-LTGEVVALKKIRLD-TETEGVPSTAIREISLLKELNHPNIVKLLDVIHTE------N------KLYLVFEFLHQDLKKFMDASAL---TGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVT-RRALFPGDSEIDQLFRIFRTLGT-----------------P----DEVVWPGVTSMPDYKPSFPKWARQ--DFSKVVPP-LDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
51 PsiBlast_CBE 68.5341%-131 - C2 -3TIY CDK2_HUMAN A:[2-287] -ENFQKVEKIGEGTYGVVYKARNK-LTGEVVALKKIR-----TEGVPSTAIREISLLKELNHPNIVKLLDVIHTE------N------KLYLVFEFLHQDLKKFMDASAL---TGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVT-RRALFPGDSEIDQLFRIFRTLGT-----------------P----DEVVWPGVTSMPDYKPSFPKWARQ--DFSKVVPP-LDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
82 PsiBlast_CBE 68.4341%-130 - C2 -2VTS CDK2_HUMAN A:[1-287] MENFQKVEKIGEGTYGVVYKARNK-LTGEVVALKKIR---------PSTAIREISLLKELNHPNIVKLLDVIHTE------N------KLYLVFEFLHQDLKKFMDASAL---TGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAF--------HEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVT-RRALFPGDSEIDQLFRIFRTLGT-----------------P----DEVVWPGVTSMPDYKPSFPKWARQ--DFSKVVPP-LDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
44 PsiBlast_CBE 68.4141%-130 - C2 -4BZD CDK2_HUMAN A:[2-288] MENFQKVEKIGEG-YGVVYKARNK-LTGEVVALKKIRL-------VPSTAIREISLLKELNHPNIVKLLDVIHTE------N------KLYLVFEFLHQDLKKFMDASAL---TGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGL--------------VVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVT-RRALFPGDSEIDQLFRIFRTLGT-----------------P----DEVVWPGVTSMPDYKPSFPKWARQ--DFSKVVPP-LDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------