@TOME V2.3
(Nov 2016)

Ref. - - Doc.
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Alignment:

3D Common Core:

Structural Clustering:

Modeller Result :

Complexes Modeling
Templates Information:
Sequence & Result Tab:

Values color: [ Good | Correct | Middling | Bad ]Sequence color : MutatedHelixStrandConserved

Query sequence : CDKL3_HUMAN: (2015-10-05 )
MEMYETLGKVGEGSYGTVMKCKHKNTGQIVAIKIFYERPEQSVNKIAMREIKFLKQFHHENLVNLIEVFRQKKKIHLVFEFIDHTVLDELQHYCHGLESKRLRKYLFQILRAIDYLHSNNIIHRDIKPENILVSQSGITKLCDFGFARTLAAPGDIYTDYVATRWYRAPELVLKDTSYGKPVDIWALGCMIIEMATGNPYLPSSSDLDLLHKIVLKVGNLSPHLQNIFSKSPIFAGVVLPQVQHPKNARKKYPKLNGLLADIVHACLQIDPADRISSSDLLHHEYFTRDGFIEKFMPELKAKLLQEAKVNSLIKPKESSKENELRKDERKTVYTNTLLSSSVLGKEIEKEKKPKEIKVRVIKVKGGRGDISEPKKKEYEGGLGQQDANENVHPMSPDTKLVTIEPPNPINPSTNCNGLKENPHCGGSVTMPPINLTNSNLMAANLSSNLFHPSVRLTERAKKRRTSSQSIGQVMPNSRQEDPGPIQSQMEKGIFNERTGHSDQMANENKRKLNFSRSDRKEFHFPELPVTIQSKDTKGMEVKQIKMLKRESKKTESSKIPTLLNVDQNQEKQEGGDGHCEGKNLKRNRFFFW

Atome Classification :

(102 SA) .........10........20...-.....30..-......--40.-..-......50........60........70.-----.------......80........90--...---------..--...100.......110.......120.......130.......140.......150.......160.......170.......180.......190....-...200.......210.......----220.......----230.......240....--.....250----....-.--------------....260---........270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590
(Atome) (Ident) (Tito) (Num) (Ligand) (Uniprot) MEMYETLGKVGEGSYGTVMKCKHK-NTGQIVAIK-IFYERP--E-Q-SV-NKIAMREIKFLKQFHHENLVNLIEVFRQK-----K------KIHLVFEFIDHTVLDELQ--HYC---------HG--LESKRLRKYLFQILRAIDYLHSNNIIHRDIKPENILVSQSGITKLCDFGFARTLAAPGDIYTDYVATRWYRAPELVLKDTSYGKPVDIWALGCMIIEMAT-GNPYLPSSSDLDLLHKIVLKVGN----LSPHLQNIFS----KSPIFAGVVLP--QVQH--PKNARK------KYPK-L--------------NGLLAD----IVHACLQIDPADRISSSDLLHHEYFTRDGFIEKFMPELKAKLLQEAKVNSLIKPKESSKENELRKDERKTVYTNTLLSSSVLGKEIEKEKKPKEIKVRVIKVKGGRGDISEPKKKEYEGGLGQQDANENVHPMSPDTKLVTIEPPNPINPSTNCNGLKENPHCGGSVTMPPINLTNSNLMAANLSSNLFHPSVRLTERAKKRRTSSQSIGQVMPNSRQEDPGPIQSQMEKGIFNERTGHSDQMANENKRKLNFSRSDRKEFHFPELPVTIQSKDTKGMEVKQIKMLKRESKKTESSKIPTLLNVDQNQEKQEGGDGHCEGKNLKRNRFFFW
110 HHSearch 96.6399%-128 - C3 -3ZDU CDKL3_HUMAN A:[2-310] MEMYETLGKVGEGSYGTVMKCKHK-NTGQIVAIK-IFY------------NKIAMREIKFLKQFHHENLVNLIEVFRQK-----K------KIHLVFEFIDHTVLDELQ--HYC---------HG--LESKRLRKYLFQILRAIDYLHSNNIIHRDIKPENILVSQSGITKLCDFGFART-----DIYDDEVATRWYRAPELVLKDTSYGKPVDIWALGCMIIEMAT-GNPYLPSSSDLDLLHKIVLKVGN----LSPHLQNIFS----KSPIFAGVVLP--QVQH--PKNARK------KYPK-L--------------NGLLAD----IVHACLQIDPADRISSSDLLHHEYFTRDGFIEKFMPELKAKLLQEAKV-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1 PsiBlast_PDB 96.6399%-128 - C3 -3ZDU CDKL3_HUMAN A:[2-310] MEMYETLGKVGEGSYGTVMKCKHK-NTGQIVAIK-IFY------------NKIAMREIKFLKQFHHENLVNLIEVFRQK-----K------KIHLVFEFIDHTVLDELQ--HYC---------HG--LESKRLRKYLFQILRAIDYLHSNNIIHRDIKPENILVSQSGITKLCDFGFART-----DIYDDEVATRWYRAPELVLKDTSYGKPVDIWALGCMIIEMAT-GNPYLPSSSDLDLLHKIVLKVGN----LSPHLQNIFS----KSPIFAGVVLP--QVQH--PKNARK------KYPK-L--------------NGLLAD----IVHACLQIDPADRISSSDLLHHEYFTRDGFIEKFMPELKAKLLQEAKV-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
111 HHSearch 83.5958%-129 - C3 -4AAA CDKL2_HUMAN A:[24-325] MEKYENLGLVGEGSYGMVMKCRNK-DTGRIVAIK-KFLESD--D-DKMV-KKIAMREIKLLKQLRHENLVNLLEVCKKK-----K------RWYLVFEFVDHTILDDLE--LFP---------NG--LDYQVVQKYLFQIINGIGFCHSHNIIHRDIKPENILVSQSGVVKLCDFGFA------------EVATRWYRAPELLVGDVKYGKAVDVWAIGCLVTEMFM-GEPLFPGDSDIDQLYHIMMCLGN----LIPRHQELFN----KNPVFAGVRLP--EIKE--REPLER------RYPK-L--------------SEVVID----LAKKCLHIDPDKRPFCAELLHHDFFQMDGFAERFSQELQL---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2 PsiBlast_PDB 83.5857%-129 - C3 -4AAA CDKL2_HUMAN A:[24-325] MEKYENLGLVGEGSYGMVMKCRNK-DTGRIVAIK-KFLESD--DDK-MV-KKIAMREIKLLKQLRHENLVNLLEVCKKK-----K------RWYLVFEFVDHTILDDLE--LFP---------NG--LDYQVVQKYLFQIINGIGFCHSHNIIHRDIKPENILVSQSGVVKLCDFGFA------------EVATRWYRAPELLVGDVKYGKAVDVWAIGCLVTEMFM-GEPLFPGDSDIDQLYHIMMCLGN----LIPRHQELFN----KNPVFAGVRLP--EIKE--REPLER------RYPK-L--------------SEVVID----LAKKCLHIDPDKRPFCAELLHHDFFQMDGFAERFSQELQL---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3 PsiBlast_PDB 80.0657%-121 - C3 -4BBM CDKL2_HUMAN A:[24-331] MEKYENLGLVG--SYGMVMKCRNK-DTGRIVAIK-KFLESD--DDK-MV-KKIAMREIKLLKQLRHENLVNLLEVCKKK-----K------RWYLVFEFVDHTILDDLE--LFP---------NG--LDYQVVQKYLFQIINGIGFCHSHNIIHRDIKPENILVSQSGVVKLCDFGFARTLAAPGEVYDDEVATRWYRAPELLVGDVKYGKAVDVWAIGCLVTEMFM-GEPLFPGDSDIDQLYHIMMCLGN----LIPRHQELFN----KNPVFAGVRLP--EIKE--REPLER------RYPK-L--------------SEVVID----LAKKCLHIDPDKRPFCAELLHHDFFQMDGFAERFSQELQLKVQKDA---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
113 HHSearch 77.3742%-127 - C3 -4BGQ CDKL5_HUMAN A:[11-301] MNKFEILGVVGEGAYGVVLKCRHK-ETHEIVAIK-KFK----------V-KETTLRELKMLRTLKQENIVELKEAFRRR-----G------KLYLVFEYVEKNMLELLE--EMP---------NG--VPPEKVKSYIYQLIKAIHWCHKNDIVHRDIKPENLLISHNDVLKLCDFGFARNLSE----------TRWYRSPELLLG-APYGKSVDMWSVGCILGELSD-GQPLFPGESEIDQLFTIQKVLGP----LPSEQMKLFY----SNPRFHGLRFP--AVNH--PQSLER------RYLGIL--------------NSVLLD----LMKNLLKLDPADRYLTEQCLNHPTFQTQRL-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21 PsiBlast_CBE 76.9957%-122 - C3 -4BBM CDKL2_HUMAN B:[24-331] MEKYENLG-----SYGMVMKCRNK-DTGRIVAIK-KF-------------KKIAMREIKLLKQLRHENLVNLLEVC-----------------YLVFEFVDHTILDDLE--LFP---------NG--LDYQVVQKYLFQIINGIGFCHSHNIIHRDIKPENILVSQSGVVKLCDFGFARTLAAPGEVYDDEVATRWYRAPELLVGDVKYGKAVDVWAIGCLVTEMFM-GEPLFPGDSDIDQLYHIMMCLGN----LIPRHQELFN----KNPVFAGVRLP--EIKE--REPLER------RYPK-L--------------SEVVID----LAKKCLHIDPDKRPFCAELLHHDFFQMDGFAERFSQELQLKVQKDA---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5 PsiBlast_PDB 76.8342%-127 - C3 -4BGQ CDKL5_HUMAN A:[11-298] MNKFEILGVVGEGAYGVVLKCRHK-ETHEIVAIK-KFK----------V-KETTLRELKMLRTLKQENIVELKEAFRRR-----G------KLYLVFEYVEKNMLELLE--EMP---------NG--VPPEKVKSYIYQLIKAIHWCHKNDIVHRDIKPENLLISHNDVLKLCDFGFARNLSE----------TRWYRSPELLL-GAPYGKSVDMWSVGCILGELSD-GQPLFPGESEIDQLFTIQKVLGP----LPSEQMKLFY----SNPRFHGLRFP--AVNH--PQSLER------RYLGIL--------------NSVLLD----LMKNLLKLDPADRYLTEQCLNHPTFQTQRL-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22 PsiBlast_CBE 76.6549%-118 - C3 -4AGU CDKL1_HUMAN C:[3-288] -EKYEKIGKIGEGSYGVVFKCRNR-DTGQIVAIK-KFLESE--D-D-PVIKKIALREIRMLKQLKHPNLVNLLEVFRRK-----R------RLHLVFEYCDHTVLHELD--RYQ---------RG--VPEHLVKSITWQTLQAVNFCHKHNCIHRDVKPENILITKHSVIKLCDFGFARLLT------------RWYRSPELLVGDTQYGPPVDVWAIGCVFAELLS-GVPLWPGKSDVDQLYLIRKTLGD----LIPRHQQVFS----TNQYFSGVKIP--DPED--MEPLEL------KFPN-I--------------SYPALG----LLKGCLHMDPTERLTCEQLLHHPYFENIR--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
112 HHSearch 76.3548%-117 - C3 -4AGU CDKL1_HUMAN A:[3-292] -EKYEKIGKIGEGSYGVVFKCRNR-DTGQIVAIK-KFLESE--D--PVI-KKIALREIRMLKQLKHPNLVNLLEVFRRK-----R------RLHLVFEYCDHTVLHELD--RYQ---------RG--VPEHLVKSITWQTLQAVNFCHKHNCIHRDVKPENILITKHSVIKLCDFGFARLLT------------RWYRSPELLVGDTQYGPPVDVWAIGCVFAELLS-GVPLWPGKSDVDQLYLIRKTLGD----LIPRHQQVFS----TNQYFSGVKIP--DPED--MEPLEL------KFPN-I--------------SYPALG----LLKGCLHMDPTERLTCEQLLHHPYFENIR--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4 PsiBlast_PDB 75.7549%-119 - C3 -4AGU CDKL1_HUMAN A:[3-288] -EKYEKIGKIGEGSYGVVFKCRNR-DTGQIVAIK-KFLESE--D---PVIKKIALREIRMLKQLKHPNLVNLLEVFRRK-----R------RLHLVFEYCDHTVLHELD--RYQ---------RG--VPEHLVKSITWQTLQAVNFCHKHNCIHRDVKPENILITKHSVIKLCDFGFARLLT------------RWYRSPELLVGDTQYGPPVDVWAIGCVFAELLS-GVPLWPGKSDVDQLYLIRKTLGD----LIPRHQQVFS----TNQYFSGVKIP--DPED--MEPLEL------KFPN-I--------------SYPALG----LLKGCLHMDPTERLTCEQLLHHPYFENIR--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23 PsiBlast_CBE 75.5449%-121 - C3 -4AGU CDKL1_HUMAN B:[4-288] --KYEKIGKIGEGSYGVVFKCRNR-DTGQIVAIK-KFLES-----D-PVIKKIALREIRMLKQLKHPNLVNLLEVFRRK-----R------RLHLVFEYCDHTVLHELD--RYQ---------RG--VPEHLVKSITWQTLQAVNFCHKHNCIHRDVKPENILITKHSVIKLCDFGFARLLT------------RWYRSPELLVGDTQYGPPVDVWAIGCVFAELLS-GVPLWPGKSDVDQLYLIRKTLGD----LIPRHQQVFS----TNQYFSGVKIP--DPED--MEPLEL------KFPN-I--------------SYPALG----LLKGCLHMDPTERLTCEQLLHHPYFENIRE-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8 PsiBlast_PDB 68.7637%-115 - C3 -3NIZ ? A:[20-304] MEKYQKLEKVGEGTYGVVYKAK-D-SQGRIVALKRIR----------GI-PSTAIREISLLKELHHPNIVSLIDVIHSE-----R------CLTLVFEFMEKDLKKVLD--ENK---------TG--LQDSQIKIYLYQLLRGVAHCHQHRILHRDLKPQNLLINSDGALKLADFGLARAFGIPVR---HEVVTLWYRAPDVLMGSKKYSTSVDIWSIGCIFAEMIT-GKPLFPGVTDDDQLPKIFSILGT----PNPREWPQVQ----ELPLWKQRTF---QVFE--KKPWSS------IIPG-F--------------CQEGID----LLSNMLCFDPNKRISARDAMNHPYFKDLDPQI-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
127 HHSearch 67.9835%-111 - C3 -4AU8 CDK5_HUMAN A:[6-292] -QKYEKLEKIGEGTYGTVFKAKNR-ETHEIVALK-RV-------------PSSALREICLLKELKHKNIVRLHDVLH--------------KLTLVFEFCDQDLKKYFD--SCN---------GD--LDPEIVKSFLFQLLKGLGFCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVR--SAEVVTLWYRPPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGT----PTEEQWPSMT----KLPDYKP--YP--MYPA--TTSLVN------VVPK-L--------------NATGRD----LLQNLLKCNPVQRISAEEALQHPYFSDF---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6 PsiBlast_PDB 66.5337%-110 - C3 -4Y72 ? A:[6-292] MEDYTKIEKIGEGTYGVVYKGRHK-TTGQVVAMKKIRLESE--E-E-GV-PSTAIREISLLKELRHPNIVSLQDVLMQD-----S------RLYLIFEFLSMDLKKYLD--SIP---------PGQYMDSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELAT-KKPLFHGDSEIDQLFRIFRALG------TPNNE----------------VWP--EVES--LQDYKN------TFPK-WKPGSLASHVKNLDENGL--D----LLSKMLIYDPAKRISGKMALNHPYFND----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
32 PsiBlast_CBE 66.3936%-122 - C3 -3S00 CDK2_HUMAN A:[9-294] MENFQKVEKIGEGTYGVVYKARNK-LTGEVVALKKIR------T-E-GV-PSTAIREISLLKELNHPNIVKLLDVIHTE-----N------KLYLVFEFL-HQDLKKFMDASAL---------TG--IPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVT-RRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPD----YKPSF--------------PKWARQ------DFSK-V--------------VPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
93 PsiBlast_CBE 65.7936%-115 - C3 -3QRU CDK2_HUMAN A:[9-294] MENFQKVEKIGEGTYGVVYKARNK-LTGEVVALKKIRL-----T-E-GV-PSTAIREISLLKELNHPNIVKLLDVIHTE-----N------KLYLVFEFL-HQDLKKFMDASAL---------TG--IPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVT-RRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPD----YKPSF--------------PKWARQ------DFSK-V--------------VPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
41 PsiBlast_CBE 65.7536%-120 - C3 -3RM7 CDK2_HUMAN A:[9-294] MENFQKVEKIGEGTYGVVYKARNK-LTGEVVALKKIR------T-E-GV-PSTAIREISLLKELNHPNIVKLLDVIHTE-----N------KLYLVFEFL-HQDLKKFMDASAL---------TG--IPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVT-RRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPD----YKPSF--------------PKWARQ------DFSK-V--------------VPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
37 PsiBlast_CBE 65.6136%-119 - C3 -3RPO CDK2_HUMAN A:[9-294] MENFQKVEKIGEGTYGVVYKARNK-LTGEVVALKKIR------T-E-GV-PSTAIREISLLKELNHPNIVKLLDVIHTE-----N------KLYLVFEFL-HQDLKKFMDASAL---------TG--IPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVT-RRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPD----YKPSF--------------PKWARQ------DFSK-V--------------VPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
92 PsiBlast_CBE 65.6036%-117 - C3 -3QTQ CDK2_HUMAN A:[9-294] MENFQKVEKIGEGTYGVVYKARNK-LTGEVVALKKIR------T-E-GV-PSTAIREISLLKELNHPNIVKLLDVIHTE-----N------KLYLVFEFL-HQDLKKFMDASAL---------TG--IPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVT-RRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPD----YKPSF--------------PKWARQ------DFSK-V--------------VPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
62 PsiBlast_CBE 65.5236%-120 - C3 -3R83 CDK2_HUMAN A:[9-294] MENFQKVEKIGEGTYGVVYKARNK-LTGEVVALKKIR------T-E-GV-PSTAIREISLLKELNHPNIVKLLDVIHTE-----N------KLYLVFEFL-HQDLKKFMDASAL---------TG--IPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVT-RRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPD----YKPSF--------------PKWARQ------DFSK-V--------------VPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
57 PsiBlast_CBE 65.4036%-119 - C3 -3R8V CDK2_HUMAN A:[9-294] MENFQKVEKIGEGTYGVVYKARNK-LTGEVVALKKIR------T-E-GV-PSTAIREISLLKELNHPNIVKLLDVIHTE-----N------KLYLVFEFL-HQDLKKFMDASAL---------TG--IPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVT-RRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPD----YKPSF--------------PKWARQ------DFSK-V--------------VPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
73 PsiBlast_CBE 65.0936%-120 - C3 -3R1S CDK2_HUMAN A:[9-294] MENFQKVEKIGEGTYGVVYKARNK-LTGEVVALKKIR------T-E-GV-PSTAIREISLLKELNHPNIVKLLDVIHTE-----N------KLYLVFEFL-HQDLKKFMDASAL---------TG--IPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVT-RRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPD----YKPSF--------------PKWARQ------DFSK-V--------------VPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13 PsiBlast_PDB 65.0934%-115 - C3 -4KRC PHO85_YEAST A:[7-298] ---FKQLEKLGNGTYATVYKGLNK-TTGVYVALK-EVKLDS--E-E-GT-PSTAIREISLMKELKHENIVRLYDVIHTE-----N------KLTLVFEFMD----NDLK--KYMDSRTP----RG--LELNLVKYFQWQLLQGLAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPDVLMGSRTYSTSIDIWSCGCILAEMIT-GKPLFPGTNDEEQLKLIFDIMGT----PNESLWPSVT----KLPKYN----P--NIQQRPPRDLRQVLQPHTKEP--L--------------DGNLMD----FLHGLLQLNPDMRLSAKQALHHPWFAEYYH-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
63 PsiBlast_CBE 65.0236%-118 - C3 -3R7Y CDK2_HUMAN A:[9-294] MENFQKVEKIGEGTYGVVYKARNK-LTGEVVALKKIR------T-E-GV-PSTAIREISLLKELNHPNIVKLLDVIHTE-----N------KLYLVFEFL-HQDLKKFMDASAL---------TG--IPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVT-RRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPD----YKPSF--------------PKWARQ------DFSK-V--------------VPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
125 HHSearch 64.9033%-119 - C3 -1CM8 MK12_HUMAN A:[25-314] -AVYRDLQPV------AVCSAVDG-RTGAKVAIK-KLYRPFQ-S-E-LF-AKRAYRELRLLKHMRHENVIGLLDVFTPD-----ETLDDFTDFYLVMPFMGTDLGKLMK--H-----------EK--LGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQAD---SEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMIT-GKTLFKGSDHLDQLKEIMKVTGT----PPAEFVQRLQSDEAKN-YMK--GLP--ELE---KKDFAS------ILTN-A--------------SPLAVN----LLEKMLVLDAEQRVTAGEALAHPYFESLHQVQKYDDSRTLDEWKRVTYKEVLSFKP-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
70 PsiBlast_CBE 64.9036%-120 - C3 -3R6X CDK2_HUMAN A:[9-294] MENFQKVEKIGEGTYGVVYKARNK-LTGEVVALKKIR------T-E-GV-PSTAIREISLLKELNHPNIVKLLDVIHTE-----N------KLYLVFEFL-HQDLKKFMDASAL---------TG--IPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVT-RRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPD----YKPSF--------------PKWARQ------DFSK-V--------------VPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17 PsiBlast_PDB 64.8235%-113 - C3 -4EOK CDK2_HUMAN A:[4-289] MENFQKVEKIGEGTYGVVYKARNK-LTGEVVALKKIRL-------E-GV-PSTAIREISLLKELNHPNIVKLLDVIHTE-----N------KLYLVFEFLSMDLKDFMD--ASAL--------TG--IPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVT-RRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPD----YKPSF--------------PKWARQ------DFSK-V--------------VPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLR-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
100 PsiBlast_CBE 64.8136%-122 - C3 -3QQF CDK2_HUMAN A:[9-294] MENFQKVEKIGEGTYGVVYKARNK-LTGEVVALKKIR------T-E-GV-PSTAIREISLLKELNHPNIVKLLDVIHTE-----N------KLYLVFEFL-HQDLKKFMDASAL---------TG--IPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVT-RRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPD----YKPSF--------------PKWARQ------DFSK-V--------------VPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
56 PsiBlast_CBE 64.8136%-122 - C3 -3R8Z CDK2_HUMAN A:[9-294] MENFQKVEKIGEGTYGVVYKARNK-LTGEVVALKKIR------T-E-GV-PSTAIREISLLKELNHPNIVKLLDVIHTE-----N------KLYLVFEFL-HQDLKKFMDASAL---------TG--IPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVP----THEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVT-RRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPD----YKPSF--------------PKWARQ------DFSK-V--------------VPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28 PsiBlast_CBE 64.7336%-122 - C3 -4EZ3 CDK2_HUMAN A:[9-294] MENFQKVEKIGEGTYGVVYKARNK-LTGEVVALKKIR------T-E-GV-PSTAIREISLLKELNHPNIVKLLDVIHTE-----N------KLYLVFEFL-HQDLKKFMDASAL---------TG--IPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVT-RRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPD----YKPSF--------------PKWARQ------DFSK-V--------------VPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
59 PsiBlast_CBE 64.7236%-119 - C3 -3R8P CDK2_HUMAN A:[9-294] MENFQKVEKIGEGTYGVVYKARNK-LTGEVVALKKIR------T-E-GV-PSTAIREISLLKELNHPNIVKLLDVIHTE-----N------KLYLVFEFL-HQDLKKFMDASAL---------TG--IPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVT-RRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPD----YKPSF--------------PKWARQ------DFSK-V--------------VPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
82 PsiBlast_CBE 64.7136%-118 - C3 -3QX2 CDK2_HUMAN A:[9-294] MENFQKVEKIGEGTYGVVYKARNK-LTGEVVALKKIR------T-E-GV-PSTAIREISLLKELNHPNIVKLLDVIHTE-----N------KLYLVFEFL-HQDLKKFMDASAL---------TG--IPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVT-RRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPD----YKPSF--------------PKWARQ------DFSK-V--------------VPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
68 PsiBlast_CBE 64.6836%-120 - C3 -3R73 CDK2_HUMAN A:[9-294] MENFQKVEKIGEGTYGVVYKARNK-LTGEVVALKKIR------T-E-GV-PSTAIREISLLKELNHPNIVKLLDVIHTE-----N------KLYLVFEFL-HQDLKKFMDASAL---------TG--IPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVT-RRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPD----YKPSF--------------PKWARQ------DFSK-V--------------VPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
99 PsiBlast_CBE 64.4536%-118 - C3 -3QQG CDK2_HUMAN A:[9-294] MENFQKVEKIGEGTYGVVYKARNK-LTGEVVALKKIR------T-E-GV-PSTAIREISLLKELNHPNIVKLLDVIHTE-----N------KLYLVFEFL-HQDLKKFMDASAL---------TG--IPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVT-RRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPD----YKPSF--------------PKWARQ------DFSK-V--------------VPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
96 PsiBlast_CBE 64.3136%-116 - C3 -3QQK CDK2_HUMAN A:[9-294] MENFQKVEKIGEGTYGVVYKARNK-LTGEVVALKKIR------T-E-GV-PSTAIREISLLKELNHPNIVKLLDVIHTE-----N------KLYLVFEFL-HQDLKKFMDASAL---------TG--IPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVT-RRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPD----YKPSF--------------PKWARQ------DFSK-V--------------VPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------