@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : CHK2_HUMAN: (2015-10-05 )
MSRESDVEAQQSHGSSACSQPHGSVTQSQGSSSQSQGISSSSTSTMPNSSQSSHSSSGTLSSLETVSTQELYSIPEDQEPEDQEPEEPTPAPWARLWALQDGFANLECVNDNYWFGRDKSCEYCFDEPLLKRTDKYRTYSKKHFRIFREVGPKNSYIAYIEDHSGNGTFVNTELVGKGKRRPLNNNSEIALSLSRNKVFVFFDLTVDDQSVYPKALRDEYIMSKTLGSGACGEVKLAFERKTCKKVAIKIISKRKFAIGSAREADPALNVETEIEILKKLNHPCIIKIKNFFDAEDYYIVLELMEGGELFDKVVGNKRLKEATCKLYFYQMLLAVQYLHENGIIHRDLKPENVLLSSQEEDCLIKITDFGHSKILGETSLMRTLCGTPTYLAPEVLVSVGTAGYNRAVDCWSLGVILFICLSGYPPFSEHRTQVSLKDQITSGKYNFIPEVWAEVSEKALDLVKKLLVVDPKARFTTEEALRHPWLQDEDMKRKFQDLLSEENESTALPQVLAQPSTSRKRPREGEAEGAETTKRPAVCAAVL
Atome Classification :
(71 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.........260.......270------.---.......280........290-..-.-.-.-.-.300.......310...--------------------------------------...----.320.......330.......340.......350......-.-360-.......370-...-----....380-.......390....---...400-.......410.......420.......--430.......440.......450.......460.......470.......480......--------.490.......500.......510.......520.......530.......540.
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MSRE
S
D
V
E
A
Q
Q
SHGSSACSQPHGSVTQSQGSSSQSQGISSSSTSTMPNSSQSSHSSSGTL
S
S
L
E
TV
S
T
Q
E
L
YSIPEDQEPEDQEPEEPTP
A
P
W
A
R
L
W
A
L
QDGFAN
L
E
C
VNDNYWFGRDKS
C
E
Y
C
FD
E
P
L
L
K
R
T
D
K
YRT
Y
S
K
K
H
F
R
I
F
R
E
VGPKN
S
Y
I
A
Y
I
EDHSGN
G
T
F
V
N
T
E
L
VGKGKRRPLNNN
S
E
I
A
L
S
LSR
N
K
V
F
V
F
F
D
L
T
VDDQSV
Y
P
K
A
L
R
D
E
Y
I
M
S
KTLGSGACG
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
--
I
SKRKFAIGSAREADPALN
V
E
-------
T
---
E
I
E
I
L
K
KLN-H
P
C
I
I
K
I
K
NFF-DA-E-
D
-
Y
-
Y
-
I
V
L
E
LMEG
G
E
L
F
D
K
V
VG--------------------------------------N
K
R
----
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
ENG
I
I
HRDLKPE
N
V
L
LSSQ-E-E
D
C
-
L
I
K
I
TDFGHS-KIL-----
G
E
T
S
L
M
R
-
T
L
CGTPTYL
A
P
E
V
L
---
V
S
VGTA-GYNR
A
V
D
C
W
S
L
G
V
I
L
F
I
CLSGYPPFSE--H
R
T
Q
V
S
L
K
DQITSGKYN
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
VVDPKARF
T
T
E
E
A
LRHPWLQ
D
--------
E
D
M
K
R
K
F
Q
D
L
L
SEENESTA
L
P
Q
V
LAQPSTSRKRPREGEAEGAETTKRPA
V
C
AAVL
25
PsiBlast_CBE
74.94
100%
-133
- C1 -
4BDG
2
CHK2_HUMAN
A:
[8-310]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
V
Y
P
K
A
L
R
D
E
Y
I
M
S
K
T
L
G
S
---
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
--
I
S
K
---------------
N
V
E
-------
T
---
E
I
E
I
L
K
K
L
N
-
H
P
C
I
I
K
I
K
N
F
F
-
D
A
-
E
-
D
-
Y
-
Y
-
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
--------------------------------------
N
K
R
----
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
Q
-
E
-
E
D
C
-
L
I
K
I
T
D
F
G
H
S
-
K
I
L
-----
G
E
T
S
L
M
R
-
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
---
V
S
V
G
T
A
-
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
--
H
R
T
Q
V
S
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
Q
D
--------
E
D
M
K
R
K
F
Q
D
L
L
S
E
E
N
E
S
T
A
L
P
Q
V
L
-------------------------------
23
PsiBlast_CBE
74.86
100%
-129
- C1 -
4BDI
7
CHK2_HUMAN
A:
[8-313]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
V
Y
P
K
A
L
R
D
E
Y
I
M
S
K
T
L
G
----
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
--
I
S
K
-------------
A
L
N
V
E
-------
T
---
E
I
E
I
L
K
K
L
N
-
H
P
C
I
I
K
I
K
N
F
F
-
D
A
-
E
-
D
-
Y
-
Y
-
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
--------------------------------------
N
K
R
----
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
Q
-
E
-
E
D
C
-
L
I
K
I
T
D
F
G
H
S
-
K
I
L
-----
G
E
T
S
L
M
R
-
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
---
V
S
V
G
T
A
-
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
--
H
R
T
Q
V
S
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
Q
D
--------
E
D
M
K
R
K
F
Q
D
L
L
S
E
E
N
E
S
T
A
L
P
Q
V
L
A
Q
P
----------------------------
7
PsiBlast_PDB
74.29
100%
-132
- C1 -
2YCQ
1
CHK2_HUMAN
A:
[3-302]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
Y
P
K
A
L
R
D
E
Y
I
M
S
K
T
L
G
S
G
A
C
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
--
I
S
K
---------------
N
V
E
-------
T
---
E
I
E
I
L
K
K
L
N
-
H
P
C
I
I
K
I
K
N
F
F
-
D
A
-
E
-
D
-
Y
-
Y
-
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
--------------------------------------
N
K
R
----
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
Q
-
E
-
E
D
C
-
L
I
K
I
T
D
F
G
H
S
-
K
I
L
-----
G
E
T
S
L
M
R
-
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
---
V
S
V
G
T
A
-
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
--
H
R
T
Q
V
S
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
Q
D
--------
E
D
M
K
R
K
F
Q
D
L
L
S
E
E
N
E
S
T
A
L
P
Q
---------------------------------
6
PsiBlast_PDB
73.84
100%
-133
- C1 -
2YIT
1
CHK2_HUMAN
A:
[3-302]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
Y
P
K
A
L
R
D
E
Y
I
M
S
K
T
L
G
S
G
A
C
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
--
I
S
K
--------------
L
N
V
E
-------
T
---
E
I
E
I
L
K
K
L
N
-
H
P
C
I
I
K
I
K
N
F
F
-
D
A
-
E
-
D
-
Y
-
Y
-
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
--------------------------------------
N
K
R
----
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
Q
-
E
-
E
D
C
-
L
I
K
I
T
D
F
G
H
S
-
K
I
L
-----
G
E
T
S
L
M
R
-
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
---
V
S
V
G
T
A
-
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
--
H
R
T
Q
V
S
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
Q
D
--------
E
D
M
K
R
K
F
Q
D
L
L
S
E
E
N
E
S
T
A
L
P
Q
---------------------------------
13
PsiBlast_PDB
73.51
100%
-129
- C1 -
2WTI
3
CHK2_HUMAN
A:
[8-310]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
V
Y
P
K
A
L
R
D
E
Y
I
M
S
K
T
L
G
S
----
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
--
I
S
K
------------
P
A
L
N
V
E
-------
T
---
E
I
E
I
L
K
K
L
N
-
H
P
C
I
I
K
I
K
N
F
F
-
D
A
-
E
-
D
-
Y
-
Y
-
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
--------------------------------------
N
K
R
----
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
Q
-
E
-
E
D
C
-
L
I
K
I
T
D
F
G
H
S
-
K
I
L
------
E
T
S
L
M
R
-
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
---
V
S
V
G
T
A
-
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
--
H
R
T
Q
V
S
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
Q
D
--------
E
D
M
K
R
K
F
Q
D
L
L
S
E
E
N
E
S
T
A
L
P
Q
V
L
-------------------------------
31
PsiBlast_CBE
73.20
100%
-130
- C1 -
2YCF
1
CHK2_HUMAN
A:
[2-302]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
V
Y
P
K
A
L
R
D
E
Y
I
M
S
K
T
L
G
S
G
A
C
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
--
I
S
K
---------------
N
V
E
-------
T
---
E
I
E
I
L
K
K
L
N
-
H
P
C
I
I
K
I
K
N
F
F
-
D
A
-
E
-
D
-
Y
-
Y
-
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
--------------------------------------
N
K
R
----
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
Q
-
E
-
E
D
C
-
L
I
K
I
T
D
F
G
H
S
-
K
I
L
-----
G
E
T
S
L
M
R
-
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
---
V
S
V
G
T
A
-
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
--
H
R
T
Q
V
S
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
Q
D
--------
E
D
M
K
R
K
F
Q
D
L
L
S
E
E
N
E
S
T
A
L
P
Q
---------------------------------
128
HHSearch
73.19
100%
-130
- C1 -
2YCF
1
CHK2_HUMAN
A:
[2-302]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
V
Y
P
K
A
L
R
D
E
Y
I
M
S
K
T
L
G
S
G
A
C
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
--
I
S
K
---------------
N
V
E
-------
T
---
E
I
E
I
L
K
K
L
N
-
H
P
C
I
I
K
I
K
N
F
F
-
D
A
-
E
-
D
-
Y
-
Y
-
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
--------------------------------------
N
K
R
----
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
Q
-
E
-
E
D
C
-
L
I
K
I
T
D
F
G
H
S
-
K
I
L
-----
G
E
T
S
L
M
R
-
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
---
V
S
V
G
T
A
-
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
--
H
R
T
Q
V
S
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
Q
D
--------
E
D
M
K
R
K
F
Q
D
L
L
S
E
E
N
E
S
T
A
L
P
Q
---------------------------------
26
PsiBlast_CBE
73.09
100%
-133
- C1 -
4BDF
3
CHK2_HUMAN
A:
[8-310]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
V
Y
P
K
A
L
R
D
E
Y
I
M
S
K
T
L
G
----
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
--
I
S
K
---------------
N
V
E
-------
T
---
E
I
E
I
L
K
K
L
N
-
H
P
C
I
I
K
I
K
N
F
F
-
D
A
-
E
-
D
-
Y
-
Y
-
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
--------------------------------------
N
K
R
----
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
Q
-
E
-
E
D
C
-
L
I
K
I
T
D
F
G
H
S
-
K
I
L
-----
G
E
T
S
L
M
R
-
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
---
V
S
V
G
T
A
-
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
--
H
R
T
Q
V
S
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
Q
D
--------
E
D
M
K
R
K
F
Q
D
L
L
S
E
E
N
E
S
T
A
L
P
Q
V
L
-------------------------------
21
PsiBlast_CBE
73.02
100%
-130
- C1 -
4BDK
4
CHK2_HUMAN
A:
[9-311]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
Y
P
K
A
L
R
D
E
Y
I
M
S
K
T
L
G
----
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
--
I
S
K
-------------
A
L
N
V
E
-------
T
---
E
I
E
I
L
K
K
L
N
-
H
P
C
I
I
K
I
K
N
F
F
-
D
A
-
E
-
D
-
Y
-
Y
-
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
--------------------------------------
N
K
R
----
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
Q
-
E
-
E
D
C
-
L
I
K
I
T
D
F
G
H
S
-
K
I
L
-----
G
E
T
S
L
M
R
-
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
---
V
S
V
G
T
A
-
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
--
H
R
T
Q
V
S
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
Q
D
--------
E
D
M
K
R
K
F
Q
D
L
L
S
E
E
N
E
S
T
A
L
P
Q
V
L
A
------------------------------
29
PsiBlast_CBE
72.87
100%
-133
- C1 -
4BDC
2
CHK2_HUMAN
A:
[8-310]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
V
Y
P
K
A
L
R
D
E
Y
I
M
S
K
T
L
G
S
----
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
--
I
S
K
---------------
N
V
E
-------
T
---
E
I
E
I
L
K
K
L
N
-
H
P
C
I
I
K
I
K
N
F
F
-
D
A
-
E
-
D
-
Y
-
Y
-
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
--------------------------------------
N
K
R
----
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
Q
-
E
-
E
D
C
-
L
I
K
I
T
D
F
G
H
S
-
K
I
L
------
E
T
S
L
M
R
-
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
---
V
S
V
G
T
A
-
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
--
H
R
T
Q
V
S
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
Q
D
--------
E
D
M
K
R
K
F
Q
D
L
L
S
E
E
N
E
S
T
A
L
P
Q
V
L
-------------------------------
22
PsiBlast_CBE
72.86
100%
-132
- C1 -
4BDJ
1
CHK2_HUMAN
A:
[9-311]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
Y
P
K
A
L
R
D
E
Y
I
M
S
K
T
L
G
-----
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
--
I
S
K
---------------
N
V
E
-------
T
---
E
I
E
I
L
K
K
L
N
-
H
P
C
I
I
K
I
K
N
F
F
-
D
A
-
E
-
D
-
Y
-
Y
-
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
--------------------------------------
N
K
R
----
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
Q
-
E
-
E
D
C
-
L
I
K
I
T
D
F
G
H
S
-
K
I
L
------
E
T
S
L
M
R
-
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
---
V
S
V
G
T
A
-
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
--
H
R
T
Q
V
S
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
Q
D
--------
E
D
M
K
R
K
F
Q
D
L
L
S
E
E
N
E
S
T
A
L
P
Q
V
L
A
------------------------------
4
PsiBlast_PDB
72.86
100%
-132
- C1 -
2YIQ
1
CHK2_HUMAN
A:
[3-302]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
Y
P
K
A
L
R
D
E
Y
I
M
S
K
T
L
G
----
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
--
I
S
K
----------------
V
E
-------
T
---
E
I
E
I
L
K
K
L
N
-
H
P
C
I
I
K
I
K
N
F
F
-
D
A
-
E
-
D
-
Y
-
Y
-
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
--------------------------------------
N
K
R
----
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
Q
-
E
-
E
D
C
-
L
I
K
I
T
D
F
G
H
S
-
K
I
L
-----
G
E
T
S
L
M
R
-
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
---
V
S
V
G
T
A
-
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
--
H
R
T
Q
V
S
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
Q
D
--------
E
D
M
K
R
K
F
Q
D
L
L
S
E
E
N
E
S
T
A
L
P
Q
---------------------------------
5
PsiBlast_PDB
72.80
100%
-132
- C1 -
2YIR
1
CHK2_HUMAN
A:
[2-301]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
V
Y
P
K
A
L
R
D
E
Y
I
M
S
K
T
L
G
S
G
A
C
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
--
I
S
K
--------------
L
N
V
E
-------
T
---
E
I
E
I
L
K
K
L
N
-
H
P
C
I
I
K
I
K
N
F
F
-
D
A
-
E
-
D
-
Y
-
Y
-
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
--------------------------------------
N
K
R
----
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
Q
-
E
-
E
D
C
-
L
I
K
I
T
D
F
G
H
S
-
K
I
L
-----
G
E
T
S
L
M
R
-
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
---
V
S
V
G
T
A
-
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
--
H
R
T
Q
V
S
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
Q
D
--------
E
D
M
K
R
K
F
Q
D
L
L
S
E
E
N
E
S
T
A
L
P
----------------------------------
12
PsiBlast_PDB
72.58
100%
-132
- C1 -
2WTD
4
CHK2_HUMAN
A:
[8-310]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
V
Y
P
K
A
L
R
D
E
Y
I
M
S
K
T
L
G
S
----
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
--
I
S
K
------------
P
A
L
N
V
E
-------
T
---
E
I
E
I
L
K
K
L
N
-
H
P
C
I
I
K
I
K
N
F
F
-
D
A
-
E
-
D
-
Y
-
Y
-
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
--------------------------------------
N
K
R
----
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
Q
-
E
-
E
D
C
-
L
I
K
I
T
D
F
G
H
S
-
K
I
L
-------
T
S
L
M
R
-
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
---
V
S
V
G
T
A
-
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
--
H
R
T
Q
V
S
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
Q
D
--------
E
D
M
K
R
K
F
Q
D
L
L
S
E
E
N
E
S
T
A
L
P
Q
V
L
-------------------------------
14
PsiBlast_PDB
72.35
100%
-132
- C1 -
2WTJ
5
CHK2_HUMAN
A:
[8-310]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
V
Y
P
K
A
L
R
D
E
Y
I
M
S
K
T
L
G
S
----
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
--
I
S
K
------------
P
A
L
N
V
E
-------
T
---
E
I
E
I
L
K
K
L
N
-
H
P
C
I
I
K
I
K
N
F
F
-
D
A
-
E
-
D
-
Y
-
Y
-
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
--------------------------------------
N
K
R
----
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
Q
-
E
-
E
D
C
-
L
I
K
I
T
D
F
G
H
S
-
K
I
L
------
E
T
S
L
M
R
-
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
---
V
S
V
G
T
A
-
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
--
H
R
T
Q
V
S
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
Q
D
--------
E
D
M
K
R
K
F
Q
D
L
L
S
E
E
N
E
S
T
A
L
P
Q
V
L
-------------------------------
9
PsiBlast_PDB
72.10
100%
-131
- C1 -
2CN5
1
CHK2_HUMAN
A:
[8-302]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
V
Y
P
K
A
L
R
D
E
Y
I
M
S
K
T
L
G
S
G
A
C
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
--
I
S
K
R
--------------
N
V
E
-------
T
---
E
I
E
I
L
K
K
L
N
-
H
P
C
I
I
K
I
K
N
F
F
-
D
A
-
E
-
D
-
Y
-
Y
-
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
--------------------------------------
N
K
R
----
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
Q
-
E
-
E
D
C
-
L
I
K
I
T
D
F
G
H
S
-
K
I
L
-----
G
E
T
S
L
M
R
-
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
---
V
S
V
G
T
A
-
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
--
H
R
T
Q
V
S
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
Q
D
--------
E
D
M
K
R
K
F
Q
D
L
L
S
E
E
N
E
---------------------------------------
20
PsiBlast_PDB
71.99
100%
-135
- C1 -
4BDA
8
CHK2_HUMAN
A:
[8-310]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
V
Y
P
K
A
L
R
D
E
Y
I
M
S
K
T
L
G
S
----
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
--
I
S
K
---------------
N
V
E
-------
T
---
E
I
E
I
L
K
K
L
N
-
H
P
C
I
I
K
I
K
N
F
F
-
D
A
-
E
-
D
-
Y
-
Y
-
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
--------------------------------------
N
K
R
----
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
Q
-
E
-
E
D
C
-
L
I
K
I
T
D
F
G
H
S
-
K
I
L
------
E
T
S
L
M
R
-
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
---
V
S
V
G
T
A
-
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
--
H
R
T
Q
V
S
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
Q
D
--------
E
D
M
K
R
K
F
Q
D
L
L
S
E
E
N
E
S
T
A
L
P
Q
V
L
-------------------------------
32
PsiBlast_CBE
71.56
99%
-132
- C1 -
2YCR
1
CHK2_HUMAN
A:
[3-302]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
Y
P
K
A
L
R
D
E
Y
I
M
S
K
T
L
G
S
---
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
--
I
S
K
---------------
N
V
E
-------
T
---
E
I
E
I
L
K
K
L
N
-
H
P
C
I
I
K
I
K
N
F
F
-
D
A
-
E
-
D
-
Y
-
Y
-
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
--------------------------------------
N
K
R
----
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
Q
-
E
-
E
D
C
-
L
I
K
I
T
D
F
G
H
S
-
K
I
L
-----
G
E
T
S
L
M
R
-
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
---
V
S
V
G
T
A
-
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
--
H
R
T
Q
V
S
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
Q
D
--------
E
D
M
K
R
K
F
Q
D
L
L
S
E
E
N
E
S
T
A
K
P
Q
---------------------------------
28
PsiBlast_CBE
71.38
100%
-140
- C1 -
4BDD
4
CHK2_HUMAN
A:
[8-310]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
V
Y
P
K
A
L
R
D
E
Y
I
M
S
K
T
L
------
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
--
I
S
K
---------------
N
V
E
-------
T
---
E
I
E
I
L
K
K
L
N
-
H
P
C
I
I
K
I
K
N
F
F
-
D
A
-
E
-
D
-
Y
-
Y
-
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
--------------------------------------
N
K
R
----
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
Q
-
E
-
E
D
C
-
L
I
K
I
T
D
F
G
H
S
-
K
I
L
-------
T
S
L
M
R
-
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
---
V
S
V
G
T
A
-
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
--
H
R
T
Q
V
S
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
Q
D
--------
E
D
M
K
R
K
F
Q
D
L
L
S
E
E
N
E
S
T
A
L
P
Q
V
L
-------------------------------
15
PsiBlast_PDB
71.22
100%
-130
- C1 -
2XM9
1
CHK2_HUMAN
A:
[9-310]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
Y
P
K
A
L
R
D
E
Y
I
M
S
K
T
L
G
S
---
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
--
I
S
K
------------
P
A
L
N
V
E
-------
T
---
E
I
E
I
L
K
K
L
N
-
H
P
C
I
I
K
I
K
N
F
F
-
D
A
-
E
-
D
-
Y
-
Y
-
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
--------------------------------------
N
K
R
----
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
Q
-
E
-
E
D
C
-
L
I
K
I
T
D
F
G
H
S
-
K
I
L
-----
G
E
T
S
L
M
R
-
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
---
V
S
V
G
T
A
-
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
--
H
R
T
Q
V
S
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
Q
D
--------
E
D
M
K
R
K
F
Q
D
L
L
S
E
E
N
E
S
T
A
L
P
Q
V
L
-------------------------------
3
PsiBlast_PDB
71.05
100%
-133
- C1 -
2W0J
1
CHK2_HUMAN
A:
[2-302]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
V
Y
P
K
A
L
R
D
E
Y
I
M
S
K
T
L
G
S
---
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
--
I
S
K
---------------
N
V
E
-------
T
---
E
I
E
I
L
K
K
L
N
-
H
P
C
I
I
K
I
K
N
F
F
-
D
A
-
E
-
D
-
Y
-
Y
-
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
--------------------------------------
N
K
R
----
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
Q
-
E
-
E
D
C
-
L
I
K
I
T
D
F
G
H
S
-
K
I
L
-------
T
S
L
M
R
-
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
---
V
S
V
G
T
A
-
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
--
H
R
T
Q
V
S
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
Q
D
--------
E
D
M
K
R
K
F
Q
D
L
L
S
E
E
N
E
-
T
A
L
P
Q
---------------------------------
11
PsiBlast_PDB
70.86
100%
-129
- C1 -
2WTC
1
CHK2_HUMAN
A:
[9-310]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
Y
P
K
A
L
R
D
E
Y
I
M
S
K
T
L
G
S
----
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
--
I
S
K
------------
P
A
L
N
V
E
-------
T
---
E
I
E
I
L
K
K
L
N
-
H
P
C
I
I
K
I
K
N
F
F
-
D
A
-
E
-
D
-
Y
-
Y
-
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
--------------------------------------
N
K
R
----
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
Q
-
E
-
E
D
C
-
L
I
K
I
T
D
F
G
H
S
-
K
I
L
-------
T
S
L
M
R
-
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
---
V
S
V
G
T
A
-
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
--
H
R
T
Q
V
S
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
Q
D
--------
E
D
M
K
R
K
F
Q
D
L
L
S
E
E
N
E
S
T
A
L
P
Q
V
L
-------------------------------
8
PsiBlast_PDB
69.54
100%
-130
- C1 -
2YCS
1
CHK2_HUMAN
A:
[2-302]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
V
Y
P
K
A
L
R
D
E
Y
I
M
S
K
T
L
G
S
---
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
--
I
S
K
---------------
N
V
E
-------
T
---
E
I
E
I
L
K
K
L
N
-
H
P
C
I
I
K
I
K
N
F
F
-
D
A
-
E
-
D
-
Y
-
Y
-
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
--------------------------------------
N
K
R
----
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
Q
-
E
-
E
D
C
-
L
I
K
I
T
D
F
G
H
S
-
K
I
L
-------
T
S
L
M
R
-
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
---
V
S
V
G
T
A
-
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
--
H
R
T
Q
V
S
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
Q
D
--------
E
D
M
K
R
K
F
Q
D
L
L
S
E
E
N
E
S
T
A
L
P
Q
---------------------------------
10
PsiBlast_PDB
67.60
100%
-135
- C1 -
2CN8
1
CHK2_HUMAN
A:
[10-301]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
P
K
A
L
R
D
E
Y
I
M
S
K
T
L
G
S
----
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
--
I
S
K
---------------
N
V
E
-------
T
---
E
I
E
I
L
K
K
L
N
-
H
P
C
I
I
K
I
K
N
F
F
-
D
A
-
E
-
D
-
Y
-
Y
-
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
--------------------------------------
N
K
R
----
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
Q
-
E
-
E
D
C
-
L
I
K
I
T
D
F
G
H
S
-
K
I
L
-------
T
S
L
M
R
-
T
L
C
--
P
T
Y
L
A
P
E
V
L
---
V
S
V
G
T
A
-
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
--
H
---
V
S
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
Q
D
--------
E
D
M
K
R
K
F
Q
D
L
L
S
E
E
N
----------------------------------------
41
PsiBlast_CBE
54.19
42%
-126
- C1 -
4FG7
1
KCC1A_HUMAN
A:
[16-276]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
R
D
I
Y
D
F
R
D
V
L
G
T
G
A
F
S
E
V
I
L
A
E
D
K
R
T
Q
K
L
V
A
I
K
C
--
I
A
----------------
S
M
E
-------
N
---
E
I
A
V
L
H
K
I
K
-
H
P
N
I
V
A
L
D
D
I
Y
-
E
S
-
G
-
G
-
H
L
Y
-
L
I
M
Q
L
V
S
G
G
E
L
F
D
R
I
V
E
--------------------------------------
K
G
F
----
Y
T
E
R
D
A
S
R
L
I
F
Q
V
L
D
A
V
K
Y
L
H
D
L
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
Y
S
L
-
D
-
E
D
S
-
K
I
M
I
S
D
F
G
L
S
-
K
M
E
-----
D
P
G
---------
T
P
G
Y
V
A
P
E
V
L
------
A
Q
K
---
S
K
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
Y
D
---
E
N
D
A
K
L
F
E
Q
I
L
K
A
E
Y
E
F
D
S
P
Y
W
D
D
I
S
D
S
A
K
D
F
I
R
H
L
M
E
K
D
P
E
K
R
F
T
C
E
Q
A
L
Q
H
P
W
I
A
----------------------------------------------------------------
46
PsiBlast_CBE
53.89
42%
-128
- C1 -
3LIJ
1
?
A:
[35-297]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
E
M
Y
Q
R
V
K
K
L
G
S
---
G
E
V
L
L
C
R
D
K
V
T
H
V
E
R
A
I
K
I
--
I
--
R
K
-----
S
S
N
S
----
K
L
L
-------
E
---
E
V
A
V
L
K
L
L
D
-
H
P
N
I
M
K
L
Y
D
F
F
E
D
K
-
R
-
N
-
Y
-
Y
-
L
V
M
E
C
Y
K
G
G
E
L
F
D
E
I
I
H
--------------------------------------
R
M
K
----
F
N
E
V
D
A
A
V
I
I
K
Q
V
L
S
G
V
T
Y
L
H
K
H
N
I
V
H
R
D
L
K
P
E
N
L
L
L
E
S
K
-
E
-
K
D
A
-
L
I
K
I
V
D
F
G
L
S
-
A
V
F
-----
E
N
Q
K
K
M
K
-
E
R
L
G
T
A
Y
Y
I
A
P
E
V
L
-------
R
K
-
K
Y
D
E
K
C
D
V
W
S
I
G
V
I
L
F
I
L
L
A
G
Y
P
P
F
G
G
--
Q
T
D
Q
E
I
L
R
-
K
V
E
K
G
K
Y
T
F
D
S
P
E
W
K
N
V
S
E
G
A
K
D
L
I
K
Q
M
L
Q
F
D
S
Q
R
R
I
S
A
Q
Q
A
L
E
H
P
W
I
K
E
--------
M
C
S
K
K
E
S
L
P
S
L
A
N
A
I
E
N
M
R
K
F
Q
N
S
Q
K
L
A
Q
A
A
L
L
Y
M
A
S
K
L
T
S
Q
E
E
T
K
E
L
T
D
I
F
R
H
I
93
PsiBlast_CBE
51.17
38%
-121
- C1 -
3MFS
1
CSKP_HUMAN
A:
[22-294]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
D
V
Y
E
L
C
E
V
I
G
K
G
A
F
S
V
V
R
R
C
I
N
R
E
T
G
Q
Q
F
A
V
K
I
--
V
D
V
A
K
F
T
------
S
S
P
G
L
S
T
E
-------
D
L
K
R
E
A
S
I
C
H
M
L
K
-
H
P
H
I
V
E
L
L
E
T
Y
-
S
S
-
D
-
G
-
M
L
Y
-
M
V
F
E
F
M
D
G
A
D
L
C
F
E
I
V
K
--------------------------------------
R
A
D
A
G
F
V
Y
S
E
A
V
A
S
H
Y
M
R
Q
I
L
E
A
L
R
Y
C
H
D
N
N
I
I
H
R
D
V
K
P
E
N
V
L
L
A
S
K
-
E
-
N
S
A
-
P
V
K
L
G
D
F
G
V
A
-
I
Q
L
-----
G
E
S
G
L
V
A
G
G
R
V
G
T
P
H
F
M
A
P
E
V
------
V
K
R
E
-
P
Y
G
K
P
V
D
V
W
G
C
G
V
I
L
F
I
L
L
S
G
C
L
P
F
----
Y
G
T
K
E
R
L
F
E
G
I
I
K
G
K
Y
K
M
N
P
R
Q
W
S
H
I
S
E
S
A
K
D
L
V
R
R
M
L
M
L
D
P
A
E
R
I
T
V
Y
E
A
L
N
H
P
W
L
K
E
--------
R
D
R
Y
A
Y
K
I
H
L
P
E
T
V
E
Q
L
R
K
F
N
A
R
R
K
L
K
G
---------------------------
92
PsiBlast_CBE
50.74
38%
-121
- C1 -
3MFU
1
CSKP_HUMAN
A:
[22-294]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
D
V
Y
E
L
C
E
V
I
G
K
G
A
F
S
V
V
R
R
C
I
N
R
E
T
G
Q
Q
F
A
V
K
I
--
V
D
V
A
K
F
T
------
S
S
P
G
L
S
T
E
-------
D
L
K
R
E
A
S
I
C
H
M
L
K
-
H
P
H
I
V
E
L
L
E
T
Y
-
S
S
-
D
-
G
-
M
L
Y
-
M
V
F
E
F
M
D
G
A
D
L
C
F
E
I
V
K
--------------------------------------
R
A
D
A
G
F
V
Y
S
E
A
V
A
S
H
Y
M
R
Q
I
L
E
A
L
R
Y
C
H
D
N
N
I
I
H
R
D
V
K
P
E
N
V
L
L
A
S
K
-
E
-
N
S
A
-
P
V
K
L
G
D
F
G
V
A
-
I
Q
L
-----
G
E
S
G
L
V
A
G
G
R
V
G
T
P
H
F
M
A
P
E
V
------
V
K
R
E
-
P
Y
G
K
P
V
D
V
W
G
C
G
V
I
L
F
I
L
L
S
G
C
L
P
F
----
Y
G
T
K
E
R
L
F
E
G
I
I
K
G
K
Y
K
M
N
P
R
Q
W
S
H
I
S
E
S
A
K
D
L
V
R
R
M
L
M
L
D
P
A
E
R
I
T
V
Y
E
A
L
N
H
P
W
L
K
E
--------
R
D
R
Y
A
Y
K
I
H
L
P
E
T
V
E
Q
L
R
K
F
N
A
R
R
K
L
K
G
---------------------------
39
PsiBlast_CBE
50.58
42%
-132
- C1 -
4FG8
1
KCC1A_HUMAN
B:
[16-276]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
R
D
I
Y
D
F
R
D
V
L
G
T
G
A
F
S
E
V
I
L
A
E
D
K
R
T
Q
K
L
V
A
I
K
C
--
I
A
K
-------------------------
N
---
E
I
A
V
L
H
K
I
K
-
H
P
N
I
V
A
L
D
D
I
Y
-
E
S
-
G
-
G
-
H
L
Y
-
L
I
M
Q
L
V
S
G
G
E
L
F
D
R
I
V
E
--------------------------------------
K
G
F
----
Y
T
E
R
D
A
S
R
L
I
F
Q
V
L
D
A
V
K
Y
L
H
D
L
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
Y
S
L
-
D
-
E
D
S
-
K
I
M
I
S
D
F
G
-------------
G
S
V
L
S
-
T
A
C
G
T
P
G
Y
V
A
P
E
V
L
------
A
Q
K
-
P
Y
S
K
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
Y
D
---
E
N
D
A
K
L
F
E
Q
I
L
K
A
E
Y
E
F
D
S
P
Y
W
D
D
I
S
D
S
A
K
D
F
I
R
H
L
M
E
K
D
P
E
K
R
F
T
C
E
Q
A
L
Q
H
P
W
I
A
G
--------
D
T
A
L
D
K
N
I
H
Q
S
V
S
E
Q
I
K
K
N
F
A
----------------------------------
104
PsiBlast_CBE
49.08
36%
-115
- C1 -
2V7O
3
KCC2G_HUMAN
A:
[31-291]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
Y
Q
L
F
E
E
L
G
K
G
-
F
S
V
V
R
R
C
V
K
K
T
P
T
Q
E
Y
A
A
K
I
--
I
N
T
K
K
L
---
S
A
R
D
H
Q
---
K
L
E
-------
R
---
E
A
R
I
C
R
L
L
K
-
H
P
N
I
V
R
L
H
D
S
I
-
S
E
-
E
-
G
-
F
H
Y
-
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
--------------------------------------
R
E
Y
----
Y
S
E
A
D
A
S
H
C
I
H
Q
I
L
E
S
V
N
H
I
H
Q
H
D
I
V
H
R
D
L
K
P
E
N
L
L
L
A
S
K
-
C
-
K
G
A
-
A
V
K
L
A
D
F
G
L
A
I
E
V
Q
-----
G
E
Q
Q
A
W
F
-
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
---
R
K
---
D
-
P
Y
G
K
P
V
D
I
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
D
---
E
D
Q
H
K
L
Y
Q
Q
I
K
A
G
A
Y
D
F
P
S
P
E
W
D
T
V
T
P
E
A
K
N
L
I
N
Q
M
L
T
I
N
P
A
K
R
I
T
A
D
Q
A
L
K
H
P
W
V
C
Q
--------
R
S
T
V
A
S
M
M
H
R
Q
E
T
V
E
C
L
R
K
F
N
A
R
R
K
L
K
G
---------------------------
57
PsiBlast_CBE
49.05
41%
-113
- C1 -
4MXA
1
?
A:
[27-287]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
R
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
--
I
S
K
R
Q
V
K
Q
K
T
D
K
E
S
-----
L
L
-------
R
---
E
V
Q
L
L
K
Q
L
D
-
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
-
G
-
Y
-
Y
-
Y
-
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
--------------------------------------
R
K
R
----
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
E
S
K
-
S
-
K
D
A
-
N
I
R
I
I
D
F
G
L
S
-
T
H
F
-----
E
A
S
K
K
M
K
-
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
-----
H
G
T
---
Y
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
--
A
N
E
Y
D
I
L
K
-
K
V
E
K
G
K
Y
T
F
E
L
P
Q
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
A
R
D
A
L
D
H
E
W
I
Q
T
--------
Y
T
K
E
Q
I
S
V
D
V
P
S
L
D
N
A
I
L
N
I
R
Q
F
Q
G
T
Q
K
L
A
Q
A
A
L
L
Y
M
G
S
K
L
T
S
Q
D
E
T
K
E
L
T
A
I
F
H
86
PsiBlast_CBE
48.95
39%
-125
- C1 -
3Q5I
1
?
A:
[38-306]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
F
K
V
R
K
L
G
S
--
Y
G
E
V
L
L
C
K
E
K
N
G
H
S
E
K
A
I
K
V
--
I
K
K
------------------KF
H
E
E
I
Y
N
---
E
I
S
L
L
K
S
L
D
-
H
P
N
I
I
K
L
F
D
V
F
E
D
K
-
K
-
Y
-
F
-
Y
-
L
V
T
E
F
Y
E
G
G
E
L
F
E
Q
I
I
N
--------------------------------------
R
H
K
----
F
D
E
C
D
A
A
N
I
M
K
Q
I
L
S
G
I
C
Y
L
H
K
H
N
I
V
H
R
D
I
K
P
E
N
I
L
L
E
N
K
-
N
-
S
L
L
-
N
I
K
I
V
D
F
G
L
S
-
S
F
F
-----
S
K
D
Y
K
L
R
-
D
R
L
G
T
A
Y
Y
I
A
P
E
V
L
-------
K
K
-
K
Y
N
E
K
C
D
V
W
S
C
G
V
I
M
Y
I
L
L
C
G
Y
P
P
F
G
G
--
Q
N
D
Q
D
I
I
K
-
K
V
E
K
G
K
Y
Y
F
D
F
N
D
W
K
N
I
S
D
E
A
K
E
L
I
K
L
M
L
T
Y
D
Y
N
K
R
C
T
A
E
E
A
L
N
S
R
W
I
K
K
--------
Y
A
N
N
I
N
K
S
D
Q
K
T
L
C
G
A
L
S
N
M
R
K
F
E
G
S
Q
K
L
A
Q
A
A
I
L
F
I
G
S
K
L
T
T
L
E
E
R
K
E
L
T
D
I
F
K
64
PsiBlast_CBE
48.88
40%
-117
- C1 -
4WG5
1
?
A:
[26-286]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
R
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
--
I
S
K
R
Q
V
K
Q
K
T
D
K
E
S
-----
L
L
-------
R
---
E
V
Q
L
L
K
Q
L
D
-
H
P
N
I
M
K
L
Y
E
F
F
-
E
D
-
K
-
G
-
Y
F
Y
-
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
--------------------------------------
R
K
R
----
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
E
S
K
-
S
-
K
D
A
-
N
I
R
I
I
D
F
G
L
S
-
T
H
F
-----
E
A
S
K
K
M
K
-
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
-------
H
G
-
T
Y
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
--
A
N
E
Y
D
I
L
K
-
K
V
E
K
G
K
Y
T
F
E
L
P
Q
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
A
R
D
A
L
D
H
E
W
I
Q
T
--------
Y
T
K
E
Q
I
S
V
D
V
P
S
L
D
N
A
I
L
N
I
R
Q
F
Q
G
T
Q
K
L
A
Q
A
A
L
L
Y
M
G
S
K
L
T
S
Q
D
E
T
K
E
L
T
A
I
F
H
136
HHSearch
48.55
35%
-111
- C1 -
3HKO
2
?
A:
[17-336]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
G
G
S
L
L
E
L
Q
K
K
Y
H
L
K
G
A
I
G
Q
G
S
Y
G
V
V
R
V
A
I
E
N
Q
T
R
A
I
R
A
I
K
I
--
M
N
K
N
K
I
R
Q
------
K
D
V
E
R
I
K
-------
T
---
E
V
R
L
M
K
K
L
H
-
H
P
N
I
A
R
L
Y
E
V
Y
-
E
D
-
E
-
Q
Y
I
-
C
-
L
V
M
E
L
C
H
G
G
H
L
L
D
K
L
N
V
F
I
DDSTG
K
C
A
M
D
V
V
KTQICPC
P
E
C
N
E
E
A
I
N
G
SIF
R
E
S
L
D
F
V
----
Q
R
E
K
L
I
S
N
I
M
R
Q
I
F
S
A
L
H
Y
L
H
N
Q
G
I
C
H
R
D
I
K
P
E
N
F
L
F
S
T
N
-
K
--
S
F
-
E
I
K
L
V
D
F
G
L
S
-
K
E
F
YKLNN
G
---------
A
G
T
P
Y
F
V
A
P
E
V
L
---
N
T
T
-
N
E
-
S
Y
G
P
K
C
D
A
W
S
A
G
V
L
L
H
L
L
L
M
G
A
V
P
F
P
G
--
V
-
N
D
A
D
T
I
S
Q
V
L
N
K
K
L
C
F
E
N
P
N
Y
N
V
L
S
P
L
A
R
D
L
L
S
N
L
L
N
R
N
V
D
E
R
F
D
A
M
R
A
L
Q
H
P
W
I
S
Q
--------
F
S
D
K
I
Y
K
M
S
----------------------------------------------
43
PsiBlast_CBE
48.49
44%
-121
- C1 -
2JAM
3
KCC1G_HUMAN
A:
[7-265]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
R
K
T
F
I
F
M
E
V
L
G
S
G
A
F
S
E
V
F
L
V
K
Q
R
L
T
G
K
L
F
A
L
K
C
--
I
K
K
-----------
S
---
S
L
E
-------
N
---
E
I
A
V
L
K
K
I
K
-
H
E
N
I
V
T
L
E
D
I
Y
-
E
S
-
T
T
H
-
Y
-
Y
-
L
V
M
Q
L
V
S
G
G
E
L
F
D
R
I
L
E
--------------------------------------
R
G
V
----
Y
T
E
K
D
A
S
L
V
I
Q
Q
V
L
S
A
V
K
Y
L
H
E
N
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
L
T
P
-
E
-
E
N
S
-
K
I
M
I
T
D
F
G
L
S
-
K
-
M
-----
E
Q
N
G
I
M
S
-
T
A
C
G
T
P
G
Y
V
A
P
E
V
L
------
A
Q
K
-
P
Y
S
K
A
V
D
C
W
S
I
G
V
I
T
Y
I
L
L
C
G
Y
P
P
F
Y
E
---
E
T
E
S
K
L
F
E
K
I
K
E
G
Y
Y
E
F
E
S
P
F
W
D
D
I
S
E
S
A
K
D
F
I
C
H
L
L
E
K
D
P
N
E
R
Y
T
C
E
K
A
L
S
H
P
W
I
D
G
--------
N
T
A
L
H
R
D
I
Y
P
S
V
S
L
Q
I
Q
K
N
F
A
K
S
--------------------------------
42
PsiBlast_CBE
48.38
44%
-118
- C1 -
2JAM
3
KCC1G_HUMAN
B:
[7-265]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
R
K
T
F
I
F
M
E
V
L
G
S
G
A
F
S
E
V
F
L
V
K
Q
R
L
T
G
K
L
F
A
L
K
C
--
I
K
K
-----------
S
---
S
L
E
-------
N
---
E
I
A
V
L
K
K
I
K
-
H
E
N
I
V
T
L
E
D
I
Y
-
E
S
-
T
T
H
-
Y
-
Y
-
L
V
M
Q
L
V
S
G
G
E
L
F
D
R
I
L
E
--------------------------------------
R
G
V
----
Y
T
E
K
D
A
S
L
V
I
Q
Q
V
L
S
A
V
K
Y
L
H
E
N
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
L
T
P
-
E
-
E
N
S
-
K
I
M
I
T
D
F
G
L
S
-
K
-
M
-----
E
Q
N
G
I
M
S
-
T
A
C
G
T
P
G
Y
V
A
P
E
V
L
------
A
Q
K
-
P
Y
S
K
A
V
D
C
W
S
I
G
V
I
T
Y
I
L
L
C
G
Y
P
P
F
Y
E
---
E
T
E
S
K
L
F
E
K
I
K
E
G
Y
Y
E
F
E
S
P
F
W
D
D
I
S
E
S
A
K
D
F
I
C
H
L
L
E
K
D
P
N
E
R
Y
T
C
E
K
A
L
S
H
P
W
I
D
G
--------
N
T
A
L
H
R
D
I
Y
P
S
V
S
L
Q
I
Q
K
N
F
A
K
---------------------------------
87
PsiBlast_CBE
48.21
38%
-124
- C1 -
4QOX
1
CDPK4_PLAF7
A:
[74-338]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
F
N
E
Q
Y
K
G
I
K
I
L
G
K
G
S
F
G
E
V
I
L
S
R
D
K
H
T
G
H
E
Y
A
I
K
V
--
I
S
K
K
H
V
K
R
K
T
D
K
E
S
-----
L
L
-------
R
---
E
V
E
L
L
K
M
L
D
-
H
I
N
I
M
K
L
Y
E
F
F
E
D
N
-
N
-
Y
-
Y
-
Y
-
L
V
S
D
V
Y
T
G
G
E
L
F
D
E
I
I
S
--------------------------------------
R
K
R
----
F
Y
E
I
D
A
A
R
I
I
K
Q
I
L
S
G
I
T
Y
M
H
K
N
N
V
V
H
R
D
L
K
P
E
N
I
L
L
E
T
K
N--
E
D
M
-
I
I
K
I
I
D
F
G
L
S
-
T
H
F
-----
E
Y
S
------
K
I
G
T
A
Y
Y
I
A
P
D
V
L
-------
H
G
-
T
Y
D
E
K
C
D
I
W
S
C
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
--
S
N
E
Y
D
I
L
K
-
K
V
E
A
G
K
Y
T
F
D
L
P
Q
F
K
K
I
S
D
K
A
K
D
L
I
K
K
M
L
M
Y
T
S
A
V
R
I
S
A
R
D
A
L
E
H
E
W
I
K
M
--------
M
T
S
K
L
E
L
S
I
A
N
I
R
Q
F
Q
S
T
Q
K
L
A
Q
A
A
L
L
Y
M
G
S
K
L
T
T
I
D
E
T
K
E
L
T
K
I
F
K
K
M
D
K
N
G
D
G
134
HHSearch
48.11
34%
-110
- C1 -
2Y0A
1
DAPK1_HUMAN
A:
[6-282]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
E
N
V
D
D
Y
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
--
I
K
K
R
R
T
K
S
--
S
R
R
G
V
S
R
E
D
I
E
-------
R
---
E
V
S
I
L
K
E
I
Q
-
H
P
N
V
I
T
L
H
E
V
Y
-
E
N
-
K
-
T
D
V
-
I
-
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
--------------------------------------
K
E
S
----
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
-
N
V
P
K
P
-
R
I
K
I
I
D
F
G
L
A
-
H
K
I
-----
D
F
G
N
E
F
K
-
N
I
F
G
T
P
E
F
V
A
P
E
I
V
---
N
Y
---
E
-
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
--
D
T
-
K
Q
E
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
P
--------
K
D
T
Q
Q
A
L
S
R
K
A
S
A
V
N
M
E
K
F
K
K
F
A
A
R
------------------------------
68
PsiBlast_CBE
47.99
40%
-111
- C1 -
4ONA
1
?
A:
[26-286]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
R
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
--
I
S
K
R
Q
V
K
Q
K
T
D
K
E
S
-----
L
L
-------
R
---
E
V
Q
L
L
K
Q
L
D
-
H
P
N
I
M
K
L
Y
E
F
F
-
E
D
-
K
-
G
-
Y
F
Y
-
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
--------------------------------------
R
K
R
----
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
E
S
K
-
S
-
K
D
A
-
N
I
R
I
I
D
F
G
L
S
-
T
H
F
-----
E
A
S
K
K
M
K
-
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
-------
H
G
-
T
Y
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
--
A
N
E
Y
D
I
L
K
-
K
V
E
K
G
K
Y
T
F
E
L
P
Q
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
A
R
D
A
L
D
H
E
W
I
Q
T
--------
Y
T
K
E
Q
I
S
V
D
V
P
S
L
D
N
A
I
L
N
I
R
Q
F
Q
G
T
Q
K
L
A
Q
A
A
L
L
Y
M
G
S
K
L
T
S
Q
D
E
T
K
E
L
T
A
I
F
H
40
PsiBlast_CBE
47.85
42%
-134
- C1 -
4FG8
1
KCC1A_HUMAN
A:
[16-276]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
R
D
I
Y
D
F
R
D
V
L
G
T
G
A
F
S
E
V
I
L
A
E
D
K
R
T
Q
K
L
V
A
I
K
C
--
I
A
K
E
------------------------
N
---
E
I
A
V
L
H
K
I
K
-
H
P
N
I
V
A
L
D
D
I
Y
-
E
S
-
G
-
G
-
H
L
Y
-
L
I
M
Q
L
V
S
G
G
E
L
F
D
R
I
V
E
--------------------------------------
K
G
F
----
Y
T
E
R
D
A
S
R
L
I
F
Q
V
L
D
A
V
K
Y
L
H
D
L
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
Y
S
L
-
D
-
E
D
S
-
K
I
M
I
S
D
F
------------------------
T
P
G
Y
V
A
P
E
V
L
------
A
Q
K
-
P
Y
S
K
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
Y
D
---
E
N
D
A
K
L
F
E
Q
I
L
K
A
E
Y
E
F
D
S
P
Y
W
D
D
I
S
D
S
A
K
D
F
I
R
H
L
M
E
K
D
P
E
K
R
F
T
C
E
Q
A
L
Q
H
P
W
I
A
G
--------
D
T
A
L
D
K
N
I
H
Q
S
V
S
E
Q
I
K
K
N
F
A
----------------------------------
47
PsiBlast_CBE
47.71
43%
-122
- C1 -
3HZT
9
?
A:
[3-263]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
D
R
Y
Q
R
V
K
K
L
G
S
G
A
Y
G
E
V
L
L
C
K
D
K
L
T
G
A
E
R
A
I
K
I
--
I
K
K
S
S
V
T
T
T
S
N
S
G
A
-----
L
L
-------
D
---
E
V
A
V
L
K
Q
L
D
-
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
-
R
-
N
-
Y
-
Y
-
L
V
M
E
V
Y
R
G
G
E
L
F
D
E
I
I
L
--------------------------------------
R
Q
K
----
F
S
E
V
D
A
A
V
I
M
K
Q
V
L
S
G
T
T
Y
L
H
K
H
N
I
V
H
R
D
L
K
P
E
N
L
L
L
E
S
K
-
S
-
R
D
A
-
L
I
K
I
V
D
F
G
L
S
-
A
H
F
-----
E
V
G
---------
T
A
Y
Y
I
A
P
E
V
L
-------
R
K
-
K
Y
D
E
K
C
D
V
W
S
C
G
V
I
L
Y
I
L
L
C
G
Y
P
P
F
G
G
--
Q
T
D
Q
E
I
L
K
-
R
V
E
K
G
K
F
S
F
D
P
P
D
W
T
Q
V
S
D
E
A
K
Q
L
V
K
L
M
L
T
Y
E
P
S
K
R
I
S
A
E
E
A
L
N
H
P
W
I
V
K
--------
F
C
S
Q
V
G
K
H
A
L
T
G
A
L
G
N
M
K
K
F
Q
S
S
Q
K
L
A
Q
A
A
M
L
F
M
G
S
K
L
T
T
L
E
E
T
K
E
L
T
Q
I
F
R
Q
L
D
58
PsiBlast_CBE
47.32
41%
-113
- C1 -
4MX9
1
?
A:
[27-287]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
R
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
--
I
S
K
R
Q
V
K
Q
K
T
D
K
E
S
-----
L
L
-------
R
---
E
V
Q
L
L
K
Q
L
D
-
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
-
G
-
Y
-
Y
-
Y
-
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
--------------------------------------
R
K
R
----
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
E
S
K
-
S
-
K
D
A
-
N
I
R
I
I
D
F
G
L
S
-
T
H
F
-----
E
A
S
K
K
M
K
-
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
-----
H
G
T
---
Y
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
--
A
N
E
Y
D
I
L
K
-
K
V
E
K
G
K
Y
T
F
E
L
P
Q
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
A
R
D
A
L
D
H
E
W
I
Q
T
--------
Y
T
K
E
Q
I
S
V
D
V
P
S
L
D
N
A
I
L
N
I
R
Q
F
Q
G
T
Q
K
L
A
Q
A
A
L
L
Y
M
G
S
K
L
T
S
Q
D
E
T
K
E
L
T
A
I
F
H
108
PsiBlast_CBE
47.24
36%
-112
- C1 -
2Y7J
1
PHKG2_HUMAN
D:
[90-364]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
E
F
Y
Q
K
Y
D
P
K
D
V
I
G
R
G
V
S
S
V
V
R
R
C
V
H
R
A
T
G
H
E
F
A
V
K
I
ME
V
---
R
L
S
P
E
Q
L
E
E
V
R
E
A
T
R
R
E
-------
T
---
H
I
-
L
R
Q
V
A
G
-
H
P
H
I
I
T
L
I
D
S
Y
-
E
S
-
S
-
S
-
F
M
F
-
L
V
F
D
L
M
R
K
G
E
L
F
D
Y
L
T
E
--------------------------------------
K
V
A
----
L
S
E
K
E
T
R
S
I
M
R
S
L
L
E
A
V
S
F
L
H
A
N
N
I
V
H
R
D
L
K
P
E
N
I
L
L
----
D
-
D
N
M
-
Q
I
R
L
S
D
F
G
F
S
-
C
H
L
-----
E
P
G
E
K
L
R
-
E
L
C
G
T
P
G
Y
L
A
P
E
I
L
KCS
M
D
E
T
H
P
-
G
Y
G
K
E
V
D
L
W
A
C
G
V
I
L
F
T
L
L
A
G
S
P
P
F
W
---
H
R
R
Q
I
L
M
L
R
M
I
M
E
G
Q
Y
Q
F
S
S
P
E
W
D
D
R
S
S
T
V
K
D
L
I
S
R
L
L
Q
V
D
P
E
A
R
L
T
A
E
Q
A
L
Q
H
P
F
F
E
R
---------------------------------------------------------------
77
PsiBlast_CBE
47.20
40%
-114
- C1 -
3T3U
5
?
A:
[26-286]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
R
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
--
I
S
K
R
Q
V
K
Q
K
T
D
K
E
S
-----
L
L
-------
R
---
E
V
Q
L
L
K
Q
L
D
-
H
P
N
I
M
K
L
Y
E
F
F
-
E
D
-
K
-
G
-
Y
F
Y
-
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
--------------------------------------
R
K
R
----
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
E
S
K
-
S
-
K
D
A
-
N
I
R
I
I
D
F
G
L
S
-
T
H
F
-----
E
A
S
K
K
M
K
-
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
-------
H
G
-
T
Y
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
--
A
N
E
Y
D
I
L
K
-
K
V
E
K
G
K
Y
T
F
E
L
P
Q
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
A
R
D
A
L
D
H
E
W
I
Q
T
--------
Y
T
K
E
Q
I
S
V
D
V
P
S
L
D
N
A
I
L
N
I
R
Q
F
Q
G
T
Q
K
L
A
Q
A
A
L
L
Y
M
G
S
K
L
T
S
Q
D
E
T
K
E
L
T
A
I
F
H
38
PsiBlast_CBE
47.10
42%
-132
- C1 -
4FG9
1
KCC1A_HUMAN
A:
[16-276]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
R
D
I
Y
D
F
R
D
V
L
G
T
G
A
F
S
E
V
I
L
A
E
D
K
R
T
Q
K
L
V
A
I
K
C
--
I
A
K
E
----------------
E
-------
N
---
E
I
A
V
L
H
K
I
K
-
H
P
N
I
V
A
L
D
D
I
Y
-
E
S
-
G
-
G
-
H
L
Y
-
L
I
M
Q
L
V
S
G
G
E
L
F
D
R
I
V
E
--------------------------------------
K
G
F
----
Y
T
E
R
D
A
S
R
L
I
F
Q
V
L
D
A
V
K
Y
L
H
D
L
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
Y
S
L
-
D
-
E
D
S
-
K
I
M
I
S
D
F
-------------------------
P
G
Y
V
A
P
E
V
L
------
A
Q
K
-
P
Y
S
K
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
Y
D
---
E
N
D
A
K
L
F
E
Q
I
L
K
A
E
Y
E
F
D
S
P
Y
W
D
D
I
S
D
S
A
K
D
F
I
R
H
L
M
E
K
D
P
E
K
R
F
T
C
E
Q
A
L
Q
H
P
W
I
A
G
--------
D
T
A
L
D
K
N
I
H
Q
S
V
S
E
Q
I
K
K
N
F
A
K
S
K
W
K
Q
A
F
N
A
T
A
V
V
R
-------------------
49
PsiBlast_CBE
46.86
40%
-114
- C1 -
2W4O
1
KCC4_HUMAN
A:
[50-344]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
L
S
D
F
F
E
V
E
S
E
L
G
R
G
A
T
S
I
V
Y
R
C
K
Q
K
G
T
Q
K
P
Y
A
L
K
V
--
L
K
K
------------------------------
I
G
V
L
L
R
L
S
-
H
P
N
I
I
K
L
K
E
I
F
-
E
T
P
T
-
E
-
I
-
S
-
L
V
L
E
L
V
T
G
G
E
L
F
D
R
I
V
E
--------------------------------------
K
G
Y
----
Y
S
E
R
D
A
A
D
A
V
K
Q
I
L
E
A
V
A
Y
L
H
E
N
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
A
T
P
-
A
-
P
D
A
-
P
L
K
I
A
D
F
-----------------------
G
T
P
G
Y
C
A
P
E
I
L
---
R
G
---
C
-
A
Y
G
P
E
V
D
M
W
S
V
G
I
I
T
Y
I
L
L
C
G
F
E
P
F
Y
D
--
E
R
G
D
Q
F
M
F
R
R
I
L
N
C
E
Y
Y
F
I
S
P
W
W
D
E
V
S
L
N
A
K
D
L
V
R
K
L
I
V
L
D
P
K
K
R
L
T
T
F
Q
A
L
Q
H
P
W
V
T
G
KAANFVHM
D
T
A
Q
K
K
L
Q
E
F
N
A
R
R
K
L
K
A
A
V
K
A
V
V
A
S
S
----------------------------
79
PsiBlast_CBE
46.76
40%
-117
- C1 -
3SX9
1
?
A:
[26-286]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
R
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
--
I
S
K
R
Q
V
K
Q
K
T
D
K
E
S
-----
L
L
-------
R
---
E
V
Q
L
L
K
Q
L
D
-
H
P
N
I
M
K
L
Y
E
F
F
-
E
D
-
K
-
G
-
Y
F
Y
-
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
--------------------------------------
R
K
R
----
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
E
S
K
-
S
-
K
D
A
-
N
I
R
I
I
D
F
G
L
S
-
T
H
F
-----
E
A
S
K
K
M
K
-
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
-------
H
G
-
T
Y
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
--
A
N
E
Y
D
I
L
K
-
K
V
E
K
G
K
Y
T
F
E
L
P
Q
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
A
R
D
A
L
D
H
E
W
I
Q
T
--------
Y
T
K
D
V
P
S
L
D
N
A
I
L
N
I
R
Q
F
Q
G
T
Q
K
L
A
Q
A
A
L
L
Y
M
G
S
K
L
T
S
Q
D
E
T
K
E
L
T
A
I
F
H
K
M
D
K
N
37
PsiBlast_CBE
46.75
42%
-133
- C1 -
4FG9
1
KCC1A_HUMAN
B:
[16-276]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
R
D
I
Y
D
F
R
D
V
L
G
T
G
A
F
S
E
V
I
L
A
E
D
K
R
T
Q
K
L
V
A
I
K
C
--
I
A
K
-----------------------------
E
I
A
V
L
H
K
I
K
-
H
P
N
I
V
A
L
D
D
I
Y
-
E
S
-
G
-
G
-
H
L
Y
-
L
I
M
Q
L
V
S
G
G
E
L
F
D
R
I
V
E
--------------------------------------
K
G
F
----
Y
T
E
R
D
A
S
R
L
I
F
Q
V
L
D
A
V
K
Y
L
H
D
L
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
Y
S
L
-
D
-
E
D
S
-
K
I
M
I
S
D
F
----------------
V
L
S
-
T
A
C
G
T
P
G
Y
V
A
P
E
V
L
------
A
Q
K
-
P
Y
S
K
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
Y
D
---
E
N
D
A
K
L
F
E
Q
I
L
K
A
E
Y
E
F
D
S
P
Y
W
D
D
I
S
D
S
A
K
D
F
I
R
H
L
M
E
K
D
P
E
K
R
F
T
C
E
Q
A
L
Q
H
P
W
I
A
G
--------
D
T
A
L
D
K
N
I
H
Q
S
V
S
E
Q
I
K
K
N
F
A
K
S
K
W
K
Q
A
F
N
A
T
A
V
V
R
-------------------
67
PsiBlast_CBE
46.65
40%
-117
- C1 -
4TZR
1
?
A:
[26-286]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
R
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
--
I
S
K
R
Q
V
K
Q
K
T
D
K
E
S
-----
L
L
-------
R
---
E
V
Q
L
L
K
Q
L
D
-
H
P
N
I
M
K
L
Y
E
F
F
-
E
D
-
K
-
G
-
Y
F
Y
-
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
--------------------------------------
R
K
R
----
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
E
S
K
-
S
-
K
D
A
-
N
I
R
I
I
D
F
G
L
S
-
T
H
F
-----
E
A
S
K
K
M
K
-
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
-------
H
G
-
T
Y
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
--
A
N
E
Y
D
I
L
K
-
K
V
E
K
G
K
Y
T
F
E
L
P
Q
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
A
R
D
A
L
D
H
E
W
I
Q
T
--------
Y
T
K
D
V
P
S
L
D
N
A
I
L
N
I
R
Q
F
Q
G
T
Q
K
L
A
Q
A
A
L
L
Y
M
G
S
K
L
T
S
Q
D
E
T
K
E
L
T
A
I
F
H
K
M
D
K
N
78
PsiBlast_CBE
46.40
40%
-112
- C1 -
3SXF
3
?
A:
[26-286]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
R
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
--
I
S
K
R
Q
V
K
Q
K
T
D
K
E
S
-----
L
L
-------
R
---
E
V
Q
L
L
K
Q
L
D
-
H
P
N
I
M
K
L
Y
E
F
F
-
E
D
-
K
-
G
-
Y
F
Y
-
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
--------------------------------------
R
K
R
----
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
E
S
K
-
S
-
K
D
A
-
N
I
R
I
I
D
F
G
L
S
-
T
H
F
-----
E
A
S
K
K
M
K
-
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
-------
H
G
-
T
Y
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
--
A
N
E
Y
D
I
L
K
-
K
V
E
K
G
K
Y
T
F
E
L
P
Q
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
A
R
D
A
L
D
H
E
W
I
Q
T
--------
Y
T
K
E
Q
I
S
V
D
V
P
S
L
D
N
A
I
L
N
I
R
Q
F
Q
G
T
Q
K
L
A
Q
A
A
L
L
Y
M
G
S
K
L
T
S
Q
D
E
T
K
E
L
T
A
I
F
H
55
PsiBlast_CBE
46.26
41%
-116
- C1 -
4IFG
1
?
A:
[49-309]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
R
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
--
I
S
K
R
Q
V
K
Q
K
T
D
K
E
S
-----
L
L
-------
R
---
E
V
Q
L
L
K
Q
L
D
-
H
P
N
I
M
K
L
Y
E
F
F
-
E
D
-
K
-
G
-
Y
F
Y
-
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
--------------------------------------
R
K
R
----
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
E
S
K
-
S
-
K
D
A
-
N
I
R
I
I
D
F
G
L
S
-
T
H
F
-----
E
A
S
K
K
M
K
-
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
-----
H
G
T
---
Y
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
--
A
N
E
Y
D
I
L
K
-
K
V
E
K
G
K
Y
T
F
E
L
P
Q
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
A
R
D
A
L
D
H
E
W
I
Q
T
--------
Y
T
K
D
V
P
S
L
D
N
A
I
L
N
I
R
Q
F
Q
G
T
Q
K
L
A
Q
A
A
L
L
Y
M
G
S
K
L
T
S
Q
D
E
T
K
E
L
T
A
I
F
H
K
M
D
K
N
97
PsiBlast_CBE
46.24
39%
-112
- C1 -
2PHK
2
PHKG1_RABIT
A:
[10-275]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
L
G
R
G
V
S
S
V
V
R
R
C
I
H
K
P
T
C
K
E
Y
A
V
K
I
--
I
D
V
T
G
G
G
S
F
S
A
E
E
V
Q
E
L
R
E
A
T
-------
L
K
--
E
V
D
I
L
R
K
V
S
G
H
P
N
I
I
Q
L
K
D
T
Y
-
E
T
-
N
-
T
-
F
-
F
F
L
V
F
D
L
M
K
K
G
E
L
F
D
Y
L
T
E
--------------------------------------
K
V
T
----
L
S
E
K
E
T
R
K
I
M
R
A
L
L
E
V
I
C
A
L
H
K
L
N
I
V
H
R
D
L
K
P
E
N
I
L
L
----
D
-
D
D
M
-
N
I
K
L
T
D
F
G
F
S
-
C
Q
L
-----
D
P
G
E
K
L
R
-
E
V
C
G
T
P
S
Y
L
A
P
E
I
I
E
C
S
M
N
D
N
H
P
-
G
Y
G
K
E
V
D
M
W
S
T
G
V
I
M
Y
T
L
L
A
G
S
P
P
F
W
---
H
R
K
Q
M
L
M
L
R
M
I
M
S
G
N
Y
Q
F
G
S
P
E
W
D
D
Y
S
D
T
V
K
D
L
V
S
R
F
L
V
V
Q
P
Q
K
R
Y
T
A
E
E
A
L
A
H
P
F
F
Q
Q
--------
Y
------------------------------------------------------
140
HHSearch
46.13
40%
-117
- C1 -
3MWU
1
?
A:
[18-282]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
T
F
A
E
R
Y
N
I
V
C
M
L
G
K
G
S
F
G
E
V
L
K
C
K
D
R
I
T
Q
Q
E
Y
A
V
K
V
--
I
N
K
A
S
A
K
N
------
K
D
T
S
T
I
L
-------
R
---
E
V
E
L
L
K
K
L
D
-
H
P
N
I
M
K
L
F
E
I
L
-
E
D
-
S
-
S
S
F
-
Y
-
I
V
G
E
L
Y
T
G
G
E
L
F
D
E
I
I
K
--------------------------------------
R
K
R
----
F
S
E
H
D
A
A
R
I
I
K
Q
V
F
S
G
I
T
Y
M
H
K
H
N
I
V
H
R
D
L
K
P
E
N
I
L
L
E
S
K
-
E
-
K
D
C
-
D
I
K
I
I
D
F
G
L
S
-
T
C
F
-----
Q
Q
N
-----
D
R
I
G
T
A
Y
Y
I
A
P
E
V
L
---
R
--
G
---
T
Y
D
E
K
C
D
V
W
S
A
G
V
I
L
Y
I
L
L
S
G
T
P
P
F
Y
G
---
K
N
E
Y
D
I
L
K
R
V
E
T
G
K
Y
A
F
D
L
P
Q
W
R
T
I
S
D
D
A
K
D
L
I
R
K
M
L
T
F
H
P
S
L
R
I
T
A
T
Q
C
L
E
H
P
W
I
Q
K
--------
Y
S
S
E
T
P
T
I
S
D
L
P
S
L
E
S
A
M
T
N
I
R
Q
F
Q
A
E
K
K
L
A
Q
A
A
L
L
Y
M
A
S
K
L
T
T
L
D
E
T
K
Q
L
T
E
I
F
85
PsiBlast_CBE
45.79
40%
-119
- C1 -
3MA6
1
?
A:
[32-292]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
R
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
--
I
S
K
R
Q
V
K
Q
K
T
D
K
E
S
-----
L
L
-------
R
---
E
V
Q
L
L
K
Q
L
D
-
H
P
N
I
M
K
L
Y
E
F
F
-
E
D
-
K
-
G
-
Y
F
Y
-
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
--------------------------------------
R
K
R
----
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
E
S
K
-
S
-
K
D
A
-
N
I
R
I
I
D
F
G
L
S
-
T
H
F
-----
E
-
S
K
K
M
K
-
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
-------
H
G
-
T
Y
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
--
A
N
E
Y
D
I
L
K
-
K
V
E
K
G
K
Y
T
F
E
L
P
Q
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
A
R
D
A
L
D
H
E
W
I
Q
T
--------
Y
T
K
----------------------------------------------------
80
PsiBlast_CBE
45.70
40%
-115
- C1 -
3N51
3
?
A:
[26-286]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
R
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
--
I
S
K
R
Q
V
K
Q
K
T
D
K
E
S
-----
L
L
-------
R
---
E
V
Q
L
L
K
Q
L
D
-
H
P
N
I
M
K
L
Y
E
F
F
-
E
D
-
K
-
G
-
Y
F
Y
-
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
--------------------------------------
R
K
R
----
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
E
S
K
-
S
-
K
D
A
-
N
I
R
I
I
D
F
G
L
S
-
T
H
F
-----
E
A
S
K
K
M
K
-
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
-------
H
G
-
T
Y
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
--
A
N
E
Y
D
I
L
K
-
K
V
E
K
G
K
Y
T
F
E
L
P
Q
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
A
R
D
A
L
D
H
E
W
I
Q
T
--------
Y
T
K
E
Q
I
S
V
D
V
P
S
L
D
N
A
I
L
N
I
R
Q
F
Q
G
T
Q
K
L
A
Q
A
A
L
L
Y
M
G
S
K
L
T
S
Q
D
E
T
K
E
L
T
A
I
F
H
81
PsiBlast_CBE
45.59
40%
-115
- C1 -
3I7B
4
?
A:
[26-286]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
R
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
--
I
S
K
R
Q
V
K
Q
K
T
D
K
E
S
-----
L
L
-------
R
---
E
V
Q
L
L
K
Q
L
D
-
H
P
N
I
M
K
L
Y
E
F
F
-
E
D
-
K
-
G
-
Y
F
Y
-
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
--------------------------------------
R
K
R
----
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
E
S
K
-
S
-
K
D
A
-
N
I
R
I
I
D
F
G
L
S
-
T
H
F
-----
E
A
S
K
K
M
K
-
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
-------
H
G
-
T
Y
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
--
A
N
E
Y
D
I
L
K
-
K
V
E
K
G
K
Y
T
F
E
L
P
Q
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
A
R
D
A
L
D
H
E
W
I
Q
T
--------
Y
T
K
E
Q
I
S
V
D
V
P
S
L
D
N
A
I
L
N
I
R
Q
F
Q
G
T
Q
K
L
A
Q
A
A
L
L
Y
M
G
S
K
L
T
S
Q
D
E
T
K
E
L
T
A
I
F
H
96
PsiBlast_CBE
45.39
39%
-109
- C1 -
1PHK
1
PHKG1_RABIT
A:
[23-288]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
L
G
R
G
V
S
S
V
V
R
R
C
I
H
K
P
T
C
K
E
Y
A
V
K
I
--
I
D
V
T
G
G
G
S
F
S
A
E
E
V
Q
E
L
R
E
A
T
-------
L
K
--
E
V
D
I
L
R
K
V
S
G
H
P
N
I
I
Q
L
K
D
T
Y
-
E
T
-
N
-
T
-
F
-
F
F
L
V
F
D
L
M
K
K
G
E
L
F
D
Y
L
T
E
--------------------------------------
K
V
T
----
L
S
E
K
E
T
R
K
I
M
R
A
L
L
E
V
I
C
A
L
H
K
L
N
I
V
H
R
D
L
K
P
E
N
I
L
L
----
D
-
D
D
M
-
N
I
K
L
T
D
F
G
F
S
-
C
Q
L
-----
D
P
G
E
K
L
R
-
E
V
C
G
T
P
S
Y
L
A
P
E
I
I
E
C
S
M
N
D
N
H
P
-
G
Y
G
K
E
V
D
M
W
S
T
G
V
I
M
Y
T
L
L
A
G
S
P
P
F
W
---
H
R
K
Q
M
L
M
L
R
M
I
M
S
G
N
Y
Q
F
G
S
P
E
W
D
D
Y
S
D
T
V
K
D
L
V
S
R
F
L
V
V
Q
P
Q
K
R
Y
T
A
E
E
A
L
A
H
P
F
F
Q
Q
--------
Y
V
-----------------------------------------------------
76
PsiBlast_CBE
45.31
40%
-115
- C1 -
3T3V
2
?
A:
[26-286]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
R
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
--
I
S
K
R
Q
V
K
Q
K
T
D
K
E
S
-----
L
L
-------
R
---
E
V
Q
L
L
K
Q
L
D
-
H
P
N
I
M
K
L
Y
E
F
F
-
E
D
-
K
-
G
-
Y
F
Y
-
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
--------------------------------------
R
K
R
----
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
E
S
K
-
S
-
K
D
A
-
N
I
R
I
I
D
F
G
L
S
-
T
H
F
-----
E
A
S
K
K
M
K
-
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
-------
H
G
-
T
Y
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
--
A
N
E
Y
D
I
L
K
-
K
V
E
K
G
K
Y
T
F
E
L
P
Q
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
A
R
D
A
L
D
H
E
W
I
Q
T
--------
Y
T
K
D
V
P
S
L
D
N
A
I
L
N
I
R
Q
F
Q
G
T
Q
K
L
A
Q
A
A
L
L
Y
M
G
S
K
L
T
S
Q
D
E
T
K
E
L
T
A
I
F
H
K
M
D
K
N
65
PsiBlast_CBE
45.27
40%
-114
- C1 -
4WG4
1
?
A:
[26-286]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
R
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
--
I
S
K
R
Q
V
K
Q
K
T
D
K
E
S
-----
L
L
-------
R
---
E
V
Q
L
L
K
Q
L
D
-
H
P
N
I
M
K
L
Y
E
F
F
-
E
D
-
K
-
G
-
Y
F
Y
-
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
--------------------------------------
R
K
R
----
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
E
S
K
-
S
-
K
D
A
-
N
I
R
I
I
D
F
G
L
S
-
T
H
F
-----
E
A
S
K
K
M
K
-
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
-------
H
G
-
T
Y
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
--
A
N
E
Y
D
I
L
K
-
K
V
E
K
G
K
Y
T
F
E
L
P
Q
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
A
R
D
A
L
D
H
E
W
I
Q
T
--------
Y
T
K
D
V
P
S
L
D
N
A
I
L
N
I
R
Q
F
Q
G
T
Q
K
L
A
Q
A
A
L
L
Y
M
G
S
K
L
T
S
Q
D
E
T
K
E
L
T
A
I
F
H
K
M
D
K
N
110
PsiBlast_CBE
45.17
36%
-112
- C1 -
2Y7J
1
PHKG2_HUMAN
A:
[90-364]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
E
F
Y
Q
K
Y
D
P
K
D
V
I
G
R
G
V
S
S
V
V
R
R
C
V
H
R
A
T
G
H
E
F
A
V
K
I
M
E
V
T
A
E
R
L
S
P
E
Q
L
E
E
V
R
E
A
T
R
R
E
-------
T
---
H
I
-
L
R
Q
V
A
G
-
H
P
H
I
I
T
L
I
D
S
Y
-
E
S
-
S
-
S
-
F
M
F
-
L
V
F
D
L
M
R
K
G
E
L
F
D
Y
L
T
E
--------------------------------------
K
V
A
----
L
S
E
K
E
T
R
S
I
M
R
S
L
L
E
A
V
S
F
L
H
A
N
N
I
V
H
R
D
L
K
P
E
N
I
L
L
----
D
-
D
N
M
-
Q
I
R
L
S
D
F
G
F
S
-
C
H
L
-----
E
P
G
E
K
L
R
-
E
L
C
G
T
P
G
Y
L
A
P
E
I
L
K
C
S
M
D
E
T
H
P
-
G
Y
G
K
E
V
D
L
W
A
C
G
V
I
L
F
T
L
L
A
G
S
P
P
F
W
---
H
R
R
Q
I
L
M
L
R
M
I
M
E
G
Q
Y
Q
F
S
S
P
E
W
D
D
R
S
S
T
V
K
D
L
I
S
R
L
L
Q
V
D
P
E
A
R
L
T
A
E
Q
A
L
Q
H
P
F
F
E
R
---------------------------------------------------------------
73
PsiBlast_CBE
45.12
40%
-116
- C1 -
3V51
1
?
A:
[26-286]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
R
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
--
I
S
K
R
Q
V
K
Q
K
T
D
K
E
S
-----
L
L
-------
R
---
E
V
Q
L
L
K
Q
L
D
-
H
P
N
I
M
K
L
Y
E
F
F
-
E
D
-
K
-
G
-
Y
F
Y
-
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
--------------------------------------
R
K
R
----
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
E
S
K
-
S
-
K
D
A
-
N
I
R
I
I
D
F
G
L
S
-
T
H
F
-----
E
A
S
K
K
M
K
-
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
-------
H
G
-
T
Y
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
--
A
N
E
Y
D
I
L
K
-
K
V
E
K
G
K
Y
T
F
E
L
P
Q
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
A
R
D
A
L
D
H
E
W
I
Q
T
--------
Y
T
K
D
V
P
S
L
D
N
A
I
L
N
I
R
Q
F
Q
G
T
Q
K
L
A
Q
A
A
L
L
Y
M
G
S
K
L
T
S
Q
D
E
T
K
E
L
T
A
I
F
H
K
M
D
K
N
48
PsiBlast_CBE
45.10
39%
-128
- C1 -
4PDS
1
RAD53_YEAST
B:
[26-302]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
G
I
F
K
D
F
S
I
I
------------------------
A
T
V
K
K
A
I
E
R
T
T
G
K
T
F
S
V
K
I
--
I
------------------
V
T
-------
R
---
E
L
E
V
L
Q
K
L
N
-
H
P
R
I
V
R
L
K
G
F
Y
--------
Y
-
Y
-
M
V
M
E
F
V
S
G
G
D
L
M
D
F
V
A
A
--------------------------------------
H
G
A
----
V
G
E
D
A
G
R
E
I
S
R
Q
I
L
T
A
I
K
Y
I
H
S
M
G
I
S
H
R
D
L
K
P
D
N
I
L
I
-
E
Q
-
D
-
D
P
V
-
L
V
K
I
T
A
F
G
L
A
-
K
V
------------------
T
L
A
Y
V
A
P
E
V
I
---------N
E
Y
S
S
L
V
D
M
W
S
M
G
C
L
V
Y
V
I
L
T
G
H
L
P
F
S
---
G
S
T
Q
D
Q
L
Y
K
Q
I
G
R
G
S
Y
H
E
G
P
L
K
D
F
R
I
S
E
E
A
R
D
F
I
D
S
L
L
Q
V
D
P
N
N
R
S
T
A
A
K
A
L
N
H
P
W
I
K
M
--------
S
P
L
Y
G
D
F
S
Q
I
S
L
S
Q
S
L
S
Q
Q
K
L
L
---------------------------------
83
PsiBlast_CBE
44.79
40%
-109
- C1 -
2WEI
1
?
A:
[22-281]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
R
Y
N
I
V
C
M
L
G
K
G
S
F
G
E
V
L
K
C
K
D
R
I
T
Q
Q
E
Y
A
V
K
V
--
I
N
K
-----
A
S
A
K
N
K
D
T
S
-
T
I
L
-------
R
---
E
V
E
L
L
K
K
L
D
-
H
P
N
I
M
K
L
F
E
I
L
E
D
S
-
S
-
S
-
F
-
Y
-
I
V
G
E
L
Y
T
G
G
E
L
F
D
E
I
I
K
--------------------------------------
R
K
R
----
F
S
E
H
D
A
A
R
I
I
K
Q
V
F
S
G
I
T
Y
M
H
K
H
N
I
V
H
R
D
L
K
P
E
N
I
L
L
E
S
K
-
E
-
K
D
C
-
D
I
K
I
I
D
F
G
L
S
-
T
C
F
-----
Q
Q
N
T
K
M
K
-
D
R
I
G
T
A
Y
Y
I
A
P
E
V
L
-------
R
G
-
T
Y
D
E
K
C
D
V
W
S
A
G
V
I
L
Y
I
L
L
S
G
T
P
P
F
Y
---
G
K
N
E
Y
D
I
L
K
R
V
E
T
G
K
Y
A
F
D
L
P
Q
W
R
T
I
S
D
D
A
K
D
L
I
R
K
M
L
T
F
H
P
S
L
R
I
T
A
T
Q
C
L
E
H
P
W
I
Q
K
--------
Y
S
S
E
---------------------------------------------------
84
PsiBlast_CBE
44.73
40%
-116
- C1 -
3MA6
1
?
B:
[32-292]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
R
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
--
I
S
K
R
Q
V
K
Q
-
T
D
K
E
S
-----
L
L
-------
R
---
E
V
Q
L
L
K
Q
L
D
-
H
P
N
I
M
K
L
Y
E
F
F
-
E
D
-
K
-
G
-
Y
F
Y
-
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
--------------------------------------
R
K
R
----
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
E
S
K
-
S
-
K
D
A
-
N
I
R
I
I
D
F
G
L
S
-
T
H
F
-----
E
A
S
K
K
M
K
-
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
-------
H
G
-
T
Y
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
--
A
N
E
Y
D
I
L
K
-
K
V
E
K
G
K
Y
T
F
E
L
P
Q
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
A
R
D
A
L
D
H
E
W
I
Q
T
--------
Y
T
-----------------------------------------------------
71
PsiBlast_CBE
44.48
40%
-116
- C1 -
3V5T
1
?
A:
[26-286]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
R
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
--
I
S
K
R
Q
V
K
Q
K
T
D
K
E
S
-----
L
L
-------
R
---
E
V
Q
L
L
K
Q
L
D
-
H
P
N
I
M
K
L
Y
E
F
F
-
E
D
-
K
-
G
-
Y
F
Y
-
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
--------------------------------------
R
K
R
----
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
E
S
K
-
S
-
K
D
A
-
N
I
R
I
I
D
F
G
L
S
-
T
H
F
-----
E
A
S
K
K
M
K
-
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
-------
H
G
-
T
Y
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
--
A
N
E
Y
D
I
L
K
-
K
V
E
K
G
K
Y
T
F
E
L
P
Q
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
A
R
D
A
L
D
H
E
W
I
Q
T
--------
Y
T
K
D
V
P
S
L
D
N
A
I
L
N
I
R
Q
F
Q
G
T
Q
K
L
A
Q
A
A
L
L
Y
M
G
S
K
L
T
S
Q
D
E
T
K
E
L
T
A
I
F
H
K
M
D
K
N
95
PsiBlast_CBE
44.44
39%
-109
- C1 -
1QL6
1
PHKG1_RABIT
A:
[23-288]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
L
G
R
G
V
S
S
V
V
R
R
C
I
H
K
P
T
C
K
E
Y
A
V
K
I
--
I
D
V
T
G
G
G
S
F
S
A
E
E
V
Q
E
L
R
E
A
T
-------
L
K
--
E
V
D
I
L
R
K
V
S
G
H
P
N
I
I
Q
L
K
D
T
Y
-
E
T
-
N
-
T
-
F
-
F
F
L
V
F
D
L
M
K
K
G
E
L
F
D
Y
L
T
E
--------------------------------------
K
V
T
----
L
S
E
K
E
T
R
K
I
M
R
A
L
L
E
V
I
C
A
L
H
K
L
N
I
V
H
R
D
L
K
P
E
N
I
L
L
----
D
-
D
D
M
-
N
I
K
L
T
D
F
G
F
S
-
C
Q
L
-----
D
P
G
E
K
L
R
-
S
V
C
G
T
P
S
Y
L
A
P
E
I
I
E
C
S
M
N
D
N
H
P
-
G
Y
G
K
E
V
D
M
W
S
T
G
V
I
M
Y
T
L
L
A
G
S
P
P
F
W
---
H
R
K
Q
M
L
M
L
R
M
I
M
S
G
N
Y
Q
F
G
S
P
E
W
D
D
Y
S
D
T
V
K
D
L
V
S
R
F
L
V
V
Q
P
Q
K
R
Y
T
A
E
E
A
L
A
H
P
F
F
Q
Q
--------
Y
V
-----------------------------------------------------
70
PsiBlast_CBE
44.39
40%
-113
- C1 -
4JBV
1
?
A:
[26-286]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
R
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
--
I
S
K
R
Q
V
K
Q
K
T
D
K
E
S
-----
L
L
-------
R
---
E
V
Q
L
L
K
Q
L
D
-
H
P
N
I
M
K
L
Y
E
F
F
-
E
D
-
K
-
G
-
Y
F
Y
-
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
--------------------------------------
R
K
R
----
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
E
S
K
-
S
-
K
D
A
-
N
I
R
I
I
D
F
G
L
S
-
T
H
F
-----
E
A
S
K
K
M
K
-
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
-------
H
G
-
T
Y
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
--
A
N
E
Y
D
I
L
K
-
K
V
E
K
G
K
Y
T
F
E
L
P
Q
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
A
R
D
A
L
D
H
E
W
I
Q
T
--------
Y
T
K
D
V
P
S
L
D
N
A
I
L
N
I
R
Q
F
Q
G
T
Q
K
L
A
Q
A
A
L
L
Y
M
G
S
K
L
T
S
Q
D
E
T
K
E
L
T
A
I
F
H
K
M
D
K
N
109
PsiBlast_CBE
44.31
36%
-111
- C1 -
2Y7J
1
PHKG2_HUMAN
C:
[90-364]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
E
F
Y
Q
K
Y
D
P
K
D
V
I
G
R
G
V
S
S
V
V
R
R
C
V
H
R
A
T
G
H
E
F
A
V
K
I
ME
V
T
A
E
R
L
S
P
E
Q
L
E
E
V
R
E
A
T
R
R
E
-------
T
---
H
I
-
L
R
Q
V
A
G
-
H
P
H
I
I
T
L
I
D
S
Y
-
E
S
-
S
-
S
-
F
M
F
-
L
V
F
D
L
M
R
K
G
E
L
F
D
Y
L
T
E
--------------------------------------
K
V
A
----
L
S
E
K
E
T
R
S
I
M
R
S
L
L
E
A
V
S
F
L
H
A
N
N
I
V
H
R
D
L
K
P
E
N
I
L
L
----
D
-
D
N
M
-
Q
I
R
L
S
D
F
G
F
S
-
C
H
L
-----
E
P
G
E
K
L
R
-
E
L
C
G
T
P
G
Y
L
A
P
E
I
L
KCS
M
D
E
T
H
P
-
G
Y
G
K
E
V
D
L
W
A
C
G
V
I
L
F
T
L
L
A
G
S
P
P
F
W
---
H
R
R
Q
I
L
M
L
R
M
I
M
E
G
Q
Y
Q
F
S
S
P
E
W
D
D
R
S
S
T
V
K
D
L
I
S
R
L
L
Q
V
D
P
E
A
R
L
T
A
E
Q
A
L
Q
H
P
F
F
E
R
---------------------------------------------------------------
66
PsiBlast_CBE
44.16
40%
-114
- C1 -
4WG3
1
?
A:
[26-286]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
R
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
--
I
S
K
R
Q
V
K
Q
K
T
D
K
E
S
-----
L
L
-------
R
---
E
V
Q
L
L
K
Q
L
D
-
H
P
N
I
M
K
L
Y
E
F
F
-
E
D
-
K
-
G
-
Y
F
Y
-
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
--------------------------------------
R
K
R
----
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
E
S
K
-
S
-
K
D
A
-
N
I
R
I
I
D
F
G
L
S
-
T
H
F
-----
E
A
S
K
K
M
K
-
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
-------
H
G
-
T
Y
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
--
A
N
E
Y
D
I
L
K
-
K
V
E
K
G
K
Y
T
F
E
L
P
Q
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
A
R
D
A
L
D
H
E
W
I
Q
T
--------
Y
T
K
D
V
P
S
L
D
N
A
I
L
N
I
R
Q
F
Q
G
T
Q
K
L
A
Q
A
A
L
L
Y
M
G
S
K
L
T
S
Q
D
E
T
K
E
L
T
A
I
F
H
K
M
D
K
N
51
PsiBlast_CBE
43.20
41%
-117
- C1 -
3NCG
1
?
A:
[30-281]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
K
G
S
F
G
E
V
L
K
C
K
D
R
I
T
Q
Q
E
Y
A
V
K
V
--
I
N
K
-----
A
S
A
K
N
K
D
T
S
-
T
I
L
-------
R
---
E
V
E
L
L
K
K
L
D
-
H
P
N
I
M
K
L
F
E
I
L
E
D
S
-
S
-
S
-
F
-
Y
-
I
V
G
E
L
Y
T
G
G
E
L
F
D
E
I
I
K
--------------------------------------
R
K
R
----
F
S
E
H
D
A
A
R
I
I
K
Q
V
F
S
G
I
T
Y
M
H
K
H
N
I
V
H
R
D
L
K
P
E
N
I
L
L
E
S
K
-
E
-
K
D
C
-
D
I
K
I
I
D
F
G
L
S
-
T
C
F
-----
Q
Q
N
T
------
I
G
T
A
Y
Y
I
A
P
E
V
L
-------
R
G
-
T
Y
D
E
K
C
D
V
W
S
A
G
V
I
L
Y
I
L
L
S
G
T
P
P
F
Y
---
G
K
N
E
Y
D
I
L
K
R
V
E
T
G
K
Y
A
F
D
L
P
Q
W
R
T
I
S
D
D
A
K
D
L
I
R
K
M
L
T
F
H
P
S
L
R
I
T
A
T
Q
C
L
E
H
P
W
I
Q
K
--------
Y
S
S
E
T
P
T
I
S
D
L
P
S
L
E
S
A
M
T
N
I
R
Q
F
Q
A
E
K
K
L
A
Q
A
A
L
L
Y
M
A
S
K
L
T
T
L
D
E
T
K
Q
L
T
E
I
F
116
PsiBlast_CBE
41.05
38%
-104
- C1 -
4D9U
1
A:
[22-291]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
G
Y
E
V
K
E
D
I
G
V
G
S
Y
S
V
C
K
R
C
I
H
K
A
T
N
M
E
F
A
V
K
I
--
I
D
K
S
K
--------
R
D
P
T
-----------
E
---
E
I
E
I
L
L
R
Y
G
Q
H
P
N
I
I
T
L
K
D
V
Y
-
D
D
-
G
-
K
-
Y
V
Y
-
V
V
T
E
L
M
K
G
G
E
L
L
D
K
I
L
R
--------------------------------------
Q
K
F
----
F
S
E
R
E
A
S
A
V
L
F
T
I
T
K
T
V
E
Y
L
H
A
Q
G
V
V
H
R
D
L
K
P
S
N
I
L
Y
V
D
E
-
S
-
G
N
P
E
S
I
R
I
C
D
F
G
F
A
-
K
Q
L
R----
A
E
N
G
L
L
M
-
T
P
C
Y
T
A
N
F
V
A
P
E
V
L
------
E
R
Q
-
G
Y
D
A
A
C
D
I
W
S
L
G
V
L
L
Y
T
M
L
T
G
Y
T
P
F
A
N
GP
D
D
T
P
E
E
I
L
A
R
I
G
S
G
K
F
S
L
S
G
G
Y
W
N
S
V
S
D
T
A
K
D
L
V
S
K
M
L
H
V
D
P
H
Q
R
L
T
A
A
L
V
L
R
H
P
W
I
V
H
--------
W
D
Q
L
P
Q
Y
Q
L
N
R
Q
D
A
P
H
L
V
K
G
A
M
A
A
T
Y
S
A
L
N
R
N
Q
----------------------