@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : CLK2_HUMAN: (2015-10-05 )
MPHPRRYHSSERGSRGSYREHYRSRKHKRRRSRSWSSSSDRTRRRRREDSYHVRSRSSYDDRSSDRRVYDRRYCGSYRRNDYSRDRGDAYYDTDYRHSYEYQRENSSYRSQRSSRRKHRRRRRRSRTFSRSSSQHSSRRAKSVEDDAEGHLIYHVGDWLQERYEIVSTLGEGTFGRVVQCVDHRRGGARVALKIIKNVEKYKEAARLEINVLEKINEKDPDNKNLCVQMFDWFDYHGHMCISFELLGLSTFDFLKDNNYLPYPIHQVRHMAFQLCQAVKFLHDNKLTHTDLKPENILFVNSDYELTYNLEKKRDERSVKSTAVRVVDFGSATFDHEHHSTIVSTRHYRAPEVILELGWSQPCDVWSIGCIIFEYYVGFTLFQTHDNREHLAMMERILGPIPSRMIRKTRKQKYFYRGRLDWDENTSAGRYVRENCKPLRRYLTSEAEEHHQLFDLIESMLEYEPAKRLTLGEALQHPFFARLRAEPPNKLWDSSRDISR
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......--200.......210.......220.......230---.........240.......250....-...260.......270.......280.......290.......300.....-..310.....-----..-----.320.......330--.......340.......350...-....360.......370.......380.......390.......400...---..-..---410...--.-.--.----.-420--.......430--.--.----.-------------....-.440.--------....-----------..450.-......460.......470.......480.......490.......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MPHPRRYHSSERGSRG
S
Y
R
E
H
Y
R
S
R
K
H
K
R
R
RSRSWSSS
S
D
R
T
R
R
R
RREDS
Y
H
VRSRSSYDDRSSDR
R
V
Y
D
R
R
Y
CGSYRRNDYSRDRGDAYYDTDYRH
S
Y
E
YQREN
S
S
Y
R
S
Q
R
S
S
R
R
K
H
R
R
R
R
R
RSRTFSRSSSQHSSRRAKSVEDDAE
G
H
L
I
Y
H
V
G
D
W
L
Q
E
R
Y
E
I
V
S
T
LGE
G
T
F
G
R
V
V
Q
C
V
D
HRRG
G
A
R
V
A
L
K
I
I
K
N
V
E
--
K
Y
K
E
A
A
R
L
E
I
N
V
L
E
K
INEKDPDNK
N
L
C
V
Q
M
F
-----
D
W
FDYHG
H
M
C
I
S
F
E
L
LG
L
S
T
F
D
FLKD-NNYLPY
P
I
H
Q
V
R
H
M
A
F
Q
L
C
Q
A
V
K
F
L
HDNKLTHTDLKPE
N
I
L
F
VNSD
Y
E
L
T
Y
-NLE-KK
R
D
E
R
-----
S
V-----
K
S
T
A
V
R
V
V
DFGSAT--FDHEH
H
S
T
I
V
STRHYR
A
P
E
V
I
L
E-LGWSQPC
D
V
W
S
I
G
C
I
I
F
E
Y
Y
V
G
F
T
L
F
QTHD
N
R
E
H
L
A
M
M
E
R
I
LGPI
P
S
R
M
I
---
R
K
-
T
R
---
K
Q
K
Y
F
Y--R-G--R----L-DWD--ENTSA
G
R
Y
-
V
--
R
--
E
----
N
-------------
C
K
P
L
-
R
R
Y
L
T
--------
S
E
A
E
-----------
E
H
H
Q
L
F
-
D
L
I
E
S
M
L
EYEPAKRL
T
L
G
E
A
L
Q
H
P
F
F
A
R
LRAEP
P
N
KLWDSSRDISR
22
PsiBlast_CBE
93.71
99%
-119
- C1 -
3NR9
1
CLK2_HUMAN
B:
[8-354]
---------------------------------------------------------------------------------------------------------------------------------------
S
S
R
R
A
K
S
V
E
D
D
A
E
G
H
L
I
Y
H
V
G
D
W
L
Q
E
R
Y
E
I
V
S
T
L
G
E
G
T
F
G
R
V
V
Q
C
V
D
H
R
R
G
G
A
R
V
A
L
K
I
I
K
N
V
E
--
K
Y
K
E
A
A
R
L
E
I
N
V
L
E
K
I
N
E
K
D
P
D
N
K
N
L
C
V
Q
M
F
-----
D
W
F
D
Y
H
G
H
M
C
I
S
F
E
L
L
G
L
S
T
F
D
F
L
K
D
-
N
N
Y
L
P
Y
P
I
H
Q
V
R
H
M
A
F
Q
L
C
Q
A
V
K
F
L
H
D
N
K
L
T
H
T
D
L
K
P
E
N
I
L
F
V
N
S
D
Y
E
L
T
Y
-
N
L
E
-
K
K
R
D
E
R
-----
S
V
-----
K
S
T
A
V
R
V
V
D
F
G
S
A
T
--
F
D
H
E
H
H
S
T
I
V
S
T
R
H
Y
R
A
P
E
V
I
L
E
-
L
G
W
S
Q
P
C
D
V
W
S
I
G
C
I
I
F
E
Y
Y
V
G
F
T
L
F
Q
T
H
D
N
R
E
H
L
A
M
M
E
R
I
L
G
P
I
P
S
R
M
I
---
R
K
-
T
R
---
K
Q
K
Y
F
Y
--
R
-
G
--
R
----
L
-
D
W
D
--
E
N
T
S
A
G
R
Y
-
V
--
R
--
E
----
N
-------------
C
K
P
L
-
R
R
Y
L
T
--------
S
E
A
E
-----------
E
H
H
Q
L
F
-
D
L
I
E
S
M
L
E
Y
E
P
A
K
R
L
T
L
G
E
A
L
Q
H
P
F
F
A
R
L
-----------------
1
PsiBlast_PDB
93.39
99%
-123
- C1 -
3NR9
1
CLK2_HUMAN
A:
[9-356]
----------------------------------------------------------------------------------------------------------------------------------------
S
R
R
A
K
S
V
E
D
D
A
E
G
H
L
I
Y
H
V
G
D
W
L
Q
E
R
Y
E
I
V
S
T
L
G
E
G
T
F
G
R
V
V
Q
C
V
D
H
R
R
G
G
A
R
V
A
L
K
I
I
K
N
V
E
--
K
Y
K
E
A
A
R
L
E
I
N
V
L
E
K
I
N
E
K
D
P
D
N
K
N
L
C
V
Q
M
F
-----
D
W
F
D
Y
H
G
H
M
C
I
S
F
E
L
L
G
L
S
T
F
D
F
L
K
D
-
N
N
Y
L
P
Y
P
I
H
Q
V
R
H
M
A
F
Q
L
C
Q
A
V
K
F
L
H
D
N
K
L
T
H
T
D
L
K
P
E
N
I
L
F
V
N
S
D
Y
E
L
T
---------
D
E
R
-----
S
V
-----
K
S
T
A
V
R
V
V
D
F
G
S
A
T
--
F
D
H
E
H
H
S
T
I
V
S
T
R
H
Y
R
A
P
E
V
I
L
E
-
L
G
W
S
Q
P
C
D
V
W
S
I
G
C
I
I
F
E
Y
Y
V
G
F
T
L
F
Q
T
H
D
N
R
E
H
L
A
M
M
E
R
I
L
G
P
I
P
S
R
M
I
---
R
K
-
T
R
---
K
Q
K
Y
F
Y
--
R
-
G
--
R
----
L
-
D
W
D
--
E
N
T
S
A
G
R
Y
-
V
--
R
--
E
----
N
-------------
C
K
P
L
-
R
R
Y
L
T
--------
S
E
A
E
-----------
E
H
H
Q
L
F
-
D
L
I
E
S
M
L
E
Y
E
P
A
K
R
L
T
L
G
E
A
L
Q
H
P
F
F
A
R
L
R
A
---------------
21
PsiBlast_CBE
93.15
99%
-119
- C1 -
3NR9
1
CLK2_HUMAN
C:
[9-355]
----------------------------------------------------------------------------------------------------------------------------------------
S
R
R
A
K
S
V
E
D
D
A
E
G
H
L
I
Y
H
V
G
D
W
L
Q
E
R
Y
E
I
V
S
T
L
G
E
G
T
F
G
R
V
V
Q
C
V
D
H
R
R
G
G
A
R
V
A
L
K
I
I
K
N
V
E
--
K
Y
K
E
A
A
R
L
E
I
N
V
L
E
K
I
N
E
K
D
P
D
N
K
N
L
C
V
Q
M
F
-----
D
W
F
D
Y
H
G
H
M
C
I
S
F
E
L
L
G
L
S
T
F
D
F
L
K
D
-
N
N
Y
L
P
Y
P
I
H
Q
V
R
H
M
A
F
Q
L
C
Q
A
V
K
F
L
H
D
N
K
L
T
H
T
D
L
K
P
E
N
I
L
F
V
N
S
D
Y
E
L
T
Y
-
N
L
E
-
K
K
R
D
E
R
-----
S
V
-----
K
S
T
A
V
R
V
V
D
F
G
S
A
T
--
F
D
H
E
H
H
S
T
I
V
S
T
R
H
Y
R
A
P
E
V
I
L
E
-
L
G
W
S
Q
P
C
D
V
W
S
I
G
C
I
I
F
E
Y
Y
V
G
F
T
L
F
Q
T
H
D
N
R
E
H
L
A
M
M
E
R
I
L
G
P
I
P
S
R
M
I
---
R
K
-
T
R
---
K
Q
K
Y
F
Y
--
R
-
G
--
R
----
L
-
D
W
D
--
E
N
T
S
A
G
R
Y
-
V
--
R
--
E
----
N
-------------
C
K
P
L
-
R
R
Y
L
T
--------
S
E
A
E
-----------
E
H
H
Q
L
F
-
D
L
I
E
S
M
L
E
Y
E
P
A
K
R
L
T
L
G
E
A
L
Q
H
P
F
F
A
R
L
R
----------------
2
PsiBlast_PDB
87.14
71%
-118
- C1 -
2WU6
7
CLK3_HUMAN
A:
[31-375]
--------------------------------------------------------------------------------------------------------------------------------------------
R
S
V
E
D
D
K
E
G
H
L
V
C
R
I
G
D
W
L
Q
E
R
Y
E
I
V
G
N
L
G
E
G
T
F
G
K
V
V
E
C
L
D
H
A
R
G
K
S
Q
V
A
L
K
I
I
R
N
V
G
--
K
Y
R
E
A
A
R
L
E
I
N
V
L
K
K
I
K
E
K
D
K
E
N
K
F
L
C
V
L
M
S
-----
D
W
F
N
F
H
G
H
M
C
I
A
F
E
L
L
G
K
N
T
F
E
F
L
K
E
-
N
N
F
Q
P
Y
P
L
P
H
V
R
H
M
A
Y
Q
L
C
H
A
L
R
F
L
H
E
N
Q
L
T
H
T
D
L
K
P
E
N
I
L
F
V
N
S
E
F
E
T
L
Y
-
N
E
H
-
K
S
C
E
E
K
-----
S
V
-----
K
N
T
S
I
R
V
A
D
F
G
S
A
T
--
F
D
H
E
H
H
T
T
I
V
A
T
R
H
Y
R
P
P
E
V
I
L
E
-
L
G
W
A
Q
P
C
D
V
W
S
I
G
C
I
L
F
E
Y
Y
R
G
F
T
L
F
Q
T
H
E
N
R
E
H
L
V
M
M
E
K
I
L
G
P
I
P
S
H
M
I
---
H
R
-
T
R
---
K
Q
K
Y
F
Y
--
K
-
G
--
G
----
L
-
V
W
D
--
E
N
S
S
D
G
R
Y
-
V
--
K
--
E
----
N
-------------
C
K
P
L
-
K
S
Y
M
L
--------
Q
D
S
L
-----------
E
H
V
Q
L
F
-
D
L
M
R
R
M
L
E
F
D
P
A
Q
R
I
T
L
A
E
A
L
L
H
P
F
F
A
G
L
T
P
E
E
R
S
F
H
---------
3
PsiBlast_PDB
85.20
71%
-117
- C1 -
2WU7
1
CLK3_HUMAN
A:
[32-375]
---------------------------------------------------------------------------------------------------------------------------------------------
S
V
E
D
D
K
E
G
H
L
V
C
R
I
G
D
W
L
Q
E
R
Y
E
I
V
G
N
L
G
E
G
T
F
G
K
V
V
E
C
L
D
H
A
R
G
K
S
Q
V
A
L
K
I
I
R
N
V
G
--
K
Y
R
E
A
A
R
L
E
I
N
V
L
K
K
I
K
E
K
D
K
E
N
K
F
L
C
V
L
M
S
-----
D
W
F
N
F
H
G
H
M
C
I
A
F
E
L
L
G
K
N
T
F
E
F
L
K
E
-
N
N
F
Q
P
Y
P
L
P
H
V
R
H
M
A
Y
Q
L
C
H
A
L
R
F
L
H
E
N
Q
L
T
H
T
D
L
K
P
E
N
I
L
F
V
N
S
E
F
E
T
L
Y
-
N
E
H
-
K
S
C
E
E
K
-----
S
V
-----
K
N
T
S
I
R
V
A
D
F
G
S
A
T
--
F
D
H
E
H
H
T
T
I
V
A
T
R
H
Y
R
P
P
E
V
I
L
E
-
L
G
W
A
Q
P
C
D
V
W
S
I
G
C
I
L
F
E
Y
Y
R
G
F
T
L
F
Q
T
H
E
N
R
E
H
L
V
M
M
E
K
I
L
G
P
I
P
S
H
M
I
---
H
R
-
T
R
---
K
Q
K
Y
F
Y
--
K
-
G
--
G
----
L
-
V
W
D
--
E
N
S
S
D
G
R
Y
-
V
--
K
--
E
----
N
-------------
C
K
P
L
-
K
S
Y
M
L
--------
Q
D
S
L
-----------
E
H
V
Q
L
F
-
D
L
M
R
R
M
L
E
F
D
P
A
Q
R
I
T
L
A
E
A
L
L
H
P
F
F
A
G
L
T
P
E
E
R
S
F
----------
4
PsiBlast_PDB
84.85
71%
-118
- C1 -
3RAW
1
CLK3_HUMAN
A:
[31-375]
--------------------------------------------------------------------------------------------------------------------------------------------
R
S
V
E
D
D
K
E
G
H
L
V
C
R
I
G
D
W
L
Q
E
R
Y
E
I
V
G
N
L
G
E
G
T
F
G
K
V
V
E
C
L
D
H
A
R
G
K
S
Q
V
A
L
K
I
I
R
N
V
G
--
K
Y
R
E
A
A
R
L
E
I
N
V
L
K
K
I
K
E
K
D
K
E
N
K
F
L
C
V
L
M
S
-----
D
W
F
N
F
H
G
H
M
C
I
A
F
E
L
L
G
K
N
T
F
E
F
L
K
E
-
N
N
F
Q
P
Y
P
L
P
H
V
R
H
M
A
Y
Q
L
C
H
A
L
R
F
L
H
E
N
Q
L
T
H
T
D
L
K
P
E
N
I
L
F
V
N
S
E
F
E
T
L
Y
-
N
E
H
-
K
S
C
E
E
K
-----
S
V
-----
K
N
T
S
I
R
V
A
D
F
G
S
A
T
--
F
D
H
E
H
H
T
T
I
V
A
T
R
H
Y
R
P
P
E
V
I
L
E
-
L
G
W
A
Q
P
C
D
V
W
S
I
G
C
I
L
F
E
Y
Y
R
G
F
T
L
F
Q
T
H
E
N
R
E
H
L
V
M
M
E
K
I
L
G
P
I
P
S
H
M
I
---
H
R
-
T
R
---
K
Q
K
Y
F
Y
--
K
-
G
--
G
----
L
-
V
W
D
--
E
N
S
S
D
G
R
Y
-
V
--
K
--
E
----
N
-------------
C
K
P
L
-
K
S
Y
M
L
--------
Q
D
S
L
-----------
E
H
V
Q
L
F
-
D
L
M
R
R
M
L
E
F
D
P
A
Q
R
I
T
L
A
E
A
L
L
H
P
F
F
A
G
L
T
P
E
E
R
S
F
H
T
--------
23
PsiBlast_CBE
83.91
71%
-114
- C1 -
3RAW
1
CLK3_HUMAN
B:
[33-375]
----------------------------------------------------------------------------------------------------------------------------------------------
V
E
D
D
K
E
G
H
L
V
C
R
I
G
D
W
L
Q
E
R
Y
E
I
V
G
N
L
G
E
G
T
F
G
K
V
V
E
C
L
D
H
A
R
G
K
S
Q
V
A
L
K
I
I
R
N
V
G
--
K
Y
R
E
A
A
R
L
E
I
N
V
L
K
K
I
K
E
K
D
K
E
N
K
F
L
C
V
L
M
S
-----
D
W
F
N
F
H
G
H
M
C
I
A
F
E
L
L
G
K
N
T
F
E
F
L
K
E
-
N
N
F
Q
P
Y
P
L
P
H
V
R
H
M
A
Y
Q
L
C
H
A
L
R
F
L
H
E
N
Q
L
T
H
T
D
L
K
P
E
N
I
L
F
V
N
S
E
F
E
T
L
Y
-
N
E
H
-
K
S
C
E
E
K
-----
S
V
-----
K
N
T
S
I
R
V
A
D
F
G
S
A
T
--
F
D
H
E
H
H
T
T
I
V
A
T
R
H
Y
R
P
P
E
V
I
L
E
-
L
G
W
A
Q
P
C
D
V
W
S
I
G
C
I
L
F
E
Y
Y
R
G
F
T
L
F
Q
T
H
E
N
R
E
H
L
V
M
M
E
K
I
L
G
P
I
P
S
H
M
I
---
H
R
-
T
R
---
K
Q
K
Y
F
Y
--
K
-
G
--
G
----
L
-
V
W
D
--
E
N
S
S
D
G
R
Y
-
V
--
K
--
E
----
N
-------------
C
K
P
L
-
K
S
Y
M
L
--------
Q
D
S
L
-----------
E
H
V
Q
L
F
-
D
L
M
R
R
M
L
E
F
D
P
A
Q
R
I
T
L
A
E
A
L
L
H
P
F
F
A
G
L
T
P
E
E
R
S
F
H
T
--------
8
PsiBlast_PDB
82.80
65%
-122
- C1 -
2VAG
1
CLK1_HUMAN
A:
[3-336]
-----------------------------------------------------------------------------------------------------------------------------------------------------
H
L
I
C
Q
S
G
D
V
L
S
A
R
Y
E
I
V
D
T
L
G
E
G
A
F
G
K
V
V
E
C
I
D
H
K
A
G
G
R
H
V
A
V
K
I
V
K
N
V
D
--
R
Y
C
E
A
A
R
S
E
I
Q
V
L
E
H
L
N
T
T
D
P
N
S
T
F
R
C
V
Q
M
L
-----
E
W
F
E
H
H
G
H
I
C
I
V
F
E
L
L
G
L
S
T
Y
D
F
I
K
E
-
N
G
F
L
P
F
R
L
D
H
I
R
K
M
A
Y
Q
I
C
K
S
V
N
F
L
H
S
N
K
L
T
H
T
D
L
K
P
E
N
I
L
F
V
Q
S
D
Y
T
E
A
Y
-
N
----
K
R
D
E
R
-----
T
L
-----
I
N
P
D
I
K
V
V
D
F
G
S
A
T
--
Y
D
D
E
H
H
S
T
L
V
S
T
R
H
Y
R
A
P
E
V
I
L
A
-
L
G
W
S
Q
P
C
D
V
W
S
I
G
C
I
L
I
E
Y
Y
L
G
F
T
V
F
P
T
H
D
S
K
E
H
L
A
M
M
E
R
I
L
G
P
L
P
K
H
M
I
---
Q
K
-
T
R
---
K
R
K
Y
F
H
--
H
-
D
--
R
----
L
-
D
W
D
--
E
H
S
S
A
G
R
Y
-
V
--
S
--
R
----
A
-------------
C
K
P
L
-
K
E
F
M
L
--------
S
Q
D
V
-----------
E
H
E
R
L
F
-
D
L
I
Q
K
M
L
E
Y
D
P
A
K
R
I
T
L
R
E
A
L
K
H
P
F
F
D
L
L
K
----------------
37
HHSearch
82.66
66%
-119
- C1 -
1Z57
1
CLK1_HUMAN
A:
[2-337]
----------------------------------------------------------------------------------------------------------------------------------------------------
M
H
L
I
C
Q
S
G
D
V
L
S
A
R
Y
E
I
V
D
T
L
G
E
G
A
F
G
K
V
V
E
C
I
D
H
K
A
G
G
R
H
V
A
V
K
I
V
K
N
V
D
--
R
Y
C
E
A
A
R
S
E
I
Q
V
L
E
H
L
N
T
T
D
P
N
S
T
F
R
C
V
Q
M
L
-----
E
W
F
E
H
H
G
H
I
C
I
V
F
E
L
L
G
L
S
T
Y
D
F
I
K
E
-
N
G
F
L
P
F
R
L
D
H
I
R
K
M
A
Y
Q
I
C
K
S
V
N
F
L
H
S
N
K
L
T
H
T
D
L
K
P
E
N
I
L
F
V
Q
S
D
Y
T
E
A
Y
-
N
-----
R
D
E
R
-----
T
L
-----
I
N
P
D
I
K
V
V
D
F
G
S
A
T
--
Y
D
D
E
H
H
S
T
L
V
S
T
R
H
Y
R
A
P
E
V
I
L
A
-
L
G
W
S
Q
P
C
D
V
W
S
I
G
C
I
L
I
E
Y
Y
L
G
F
T
V
F
P
T
H
D
S
K
E
H
L
A
M
M
E
R
I
L
G
P
L
P
K
H
M
I
---
Q
K
-
T
R
---
K
R
K
Y
F
H
--
H
-
D
--
R
----
L
-
D
W
D
--
E
H
S
S
A
G
R
Y
-
V
--
S
--
R
----
A
-------------
C
K
P
L
-
K
E
F
M
L
--------
S
Q
D
V
-----------
E
H
E
R
L
F
-
D
L
I
Q
K
M
L
E
Y
D
P
A
K
R
I
T
L
R
E
A
L
K
H
P
F
F
D
L
L
K
K
---------------
7
PsiBlast_PDB
82.63
66%
-120
- C1 -
1Z57
1
CLK1_HUMAN
A:
[3-336]
-----------------------------------------------------------------------------------------------------------------------------------------------------
H
L
I
C
Q
S
G
D
V
L
S
A
R
Y
E
I
V
D
T
L
G
E
G
A
F
G
K
V
V
E
C
I
D
H
K
A
G
G
R
H
V
A
V
K
I
V
K
N
V
D
--
R
Y
C
E
A
A
R
S
E
I
Q
V
L
E
H
L
N
T
T
D
P
N
S
T
F
R
C
V
Q
M
L
-----
E
W
F
E
H
H
G
H
I
C
I
V
F
E
L
L
G
L
S
T
Y
D
F
I
K
E
-
N
G
F
L
P
F
R
L
D
H
I
R
K
M
A
Y
Q
I
C
K
S
V
N
F
L
H
S
N
K
L
T
H
T
D
L
K
P
E
N
I
L
F
V
Q
S
D
Y
T
E
A
Y
-
N
-----
R
D
E
R
-----
T
L
-----
I
N
P
D
I
K
V
V
D
F
G
S
A
T
--
Y
D
D
E
H
H
S
T
L
V
S
T
R
H
Y
R
A
P
E
V
I
L
A
-
L
G
W
S
Q
P
C
D
V
W
S
I
G
C
I
L
I
E
Y
Y
L
G
F
T
V
F
P
T
H
D
S
K
E
H
L
A
M
M
E
R
I
L
G
P
L
P
K
H
M
I
---
Q
K
-
T
R
---
K
R
K
Y
F
H
--
H
-
D
--
R
----
L
-
D
W
D
--
E
H
S
S
A
G
R
Y
-
V
--
S
--
R
----
A
-------------
C
K
P
L
-
K
E
F
M
L
--------
S
Q
D
V
-----------
E
H
E
R
L
F
-
D
L
I
Q
K
M
L
E
Y
D
P
A
K
R
I
T
L
R
E
A
L
K
H
P
F
F
D
L
L
K
K
---------------
38
HHSearch
68.97
38%
-109
- C1 -
3LLT
1
?
A:
[20-360]
-------------------------------------------------------------------------------------------------------------------------------------------------
D
E
I
V
H
F
S
W
K
K
G
M
L
L
N
N
A
F
L
V
I
R
K
M
G
D
G
T
F
G
R
V
L
L
C
Q
H
I
-
D
N
K
K
Y
Y
A
V
K
V
V
R
N
I
K
--
K
Y
T
R
S
A
K
I
E
A
D
I
L
K
K
I
Q
N
D
D
I
N
N
N
N
-
I
V
K
Y
H
-----
G
K
F
M
Y
Y
D
H
M
C
L
I
F
E
P
L
G
P
S
L
Y
E
I
I
T
R
-
N
N
Y
N
G
F
H
I
E
D
I
K
L
Y
C
I
E
I
L
K
A
L
N
Y
L
R
K
M
S
L
T
H
T
D
L
K
P
E
N
I
L
L
D
D
P
Y
F
E
K
S
L
-
I
T
V
R
R
V
T
D
G
K
K
I
Q
I
Y
R
T
-----
K
S
T
G
I
K
L
I
D
F
G
C
A
T
--
F
K
S
D
Y
H
G
S
I
I
N
T
R
Q
Y
R
A
P
E
V
I
L
N
-
L
G
W
D
V
S
S
D
M
W
S
F
G
C
V
L
A
E
L
Y
T
G
S
L
L
F
R
T
H
E
H
M
E
H
L
A
M
M
E
S
I
I
Q
P
I
P
K
N
M
L
---
Y
E
-
A
T
K
T
N
G
S
K
Y
V
N
--
K
-
D
--
E
LK--
L
-
A
W
P
--
E
N
A
S
S
I
N
S
-
I
K
H
V
--
K
----
K
-------------
C
L
P
L
-
Y
K
I
I
------------------------
K
H
E
L
F
C
-
D
F
L
Y
S
I
L
Q
I
D
P
T
L
R
P
S
P
A
E
L
L
K
H
K
F
L
E
-------------------
9
PsiBlast_PDB
67.90
37%
-115
- C1 -
3LLT
1
?
A:
[20-359]
-------------------------------------------------------------------------------------------------------------------------------------------------
D
E
I
V
H
F
S
W
K
K
G
M
L
L
N
N
A
F
L
V
I
R
K
M
G
D
G
T
F
G
R
V
L
L
C
-
Q
H
I
D
N
K
K
Y
Y
A
V
K
V
V
R
N
I
K
--
K
Y
T
R
S
A
K
I
E
A
D
I
L
K
K
I
-
Q
N
D
D
I
N
N
N
N
I
V
K
Y
H
-----
G
K
F
M
Y
Y
D
H
M
C
L
I
F
E
P
L
G
P
S
L
Y
E
I
I
T
R
-
N
N
Y
N
G
F
H
I
E
D
I
K
L
Y
C
I
E
I
L
K
A
L
N
Y
L
R
K
M
S
L
T
H
T
D
L
K
P
E
N
I
L
L
D
D
P
Y
F
E
K
S
L
I
T
V
R
-
R
V
T
D
G
K
-----
K
I
Q
I
Y
R
T
K
S
T
G
I
K
L
I
D
F
G
C
A
T
--
F
K
S
D
Y
H
G
S
I
I
N
T
R
Q
Y
R
A
P
E
V
I
L
N
-
L
G
W
D
V
S
S
D
M
W
S
F
G
C
V
L
A
E
L
Y
T
G
S
L
L
F
R
T
H
E
H
M
E
H
L
A
M
M
E
S
I
I
Q
P
I
P
K
N
M
L
Y
E
A
T
K
-
T
N
---
G
S
K
Y
V
N
--
K
-
D
EL
K
----
L
-
A
W
P
--
E
N
A
S
S
I
N
S
-
I
--
K
H
V
K
----
K
-------------
C
L
P
L
-
Y
K
I
I
K
-------------------------
H
E
L
F
C
D
F
L
Y
S
I
L
Q
I
D
P
T
L
R
P
S
P
A
E
L
L
K
H
K
F
L
E
-------------------
41
HHSearch
67.21
33%
-114
- C1 -
3KVW
1
DYRK2_HUMAN
A:
[80-413]
-----------------------------------------------------------------------------------------------------------------------------------------------
Y
D
D
D
Q
G
S
Y
V
Q
V
P
H
D
H
V
A
Y
R
Y
E
V
L
K
V
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
H
K
-
V
H
Q
H
V
A
L
K
M
V
R
N
E
K
--
R
F
H
R
Q
A
A
E
E
I
R
I
L
E
H
L
R
K
Q
D
K
D
N
T
M
N
V
I
H
M
L
-----
E
N
F
T
F
R
N
H
I
C
M
T
F
E
L
L
S
M
N
L
Y
E
L
I
K
K
-
N
K
F
Q
G
F
S
L
P
L
V
R
K
F
A
H
S
I
L
Q
C
L
D
A
L
H
K
N
R
I
I
H
C
D
L
K
P
E
N
I
L
L
K
Q
Q
G
-----------------------------
R
S
G
I
K
V
I
D
F
G
S
S
C
--
Y
E
H
Q
R
V
Y
T
Y
I
Q
S
R
F
Y
R
A
P
E
V
I
L
G
-
A
R
Y
G
M
P
I
D
M
W
S
L
G
C
I
L
A
E
L
L
T
G
Y
P
L
L
P
G
E
D
E
G
D
Q
L
A
C
M
I
E
L
L
G
M
P
S
Q
K
L
L
---
D
A
-
S
K
---
R
A
K
N
F
V
--
S
S
K
--
G
----
Y
P
R
Y
C
T
V
T
T
L
S
D
--
V
-
V
--
L
--
N
----
G
G
RSR
R
G
K
L
R
G
PPE
S
R
E
W
-
G
N
A
L
K
----------
G
C
-----------
D
D
P
L
F
L
-
D
F
L
K
Q
C
L
E
W
D
P
A
V
R
M
T
P
G
Q
A
L
R
H
P
W
L
R
-------------------
15
PsiBlast_PDB
66.35
31%
-118
- C1 -
4IIR
1
PRP4B_HUMAN
A:
[15-348]
-------------------------------------------------------------------------------------------------------------------------------------------------
D
A
E
G
Y
Y
R
V
N
I
G
E
V
L
D
K
R
Y
N
V
Y
G
Y
T
G
Q
G
--
S
N
V
V
R
A
R
D
N
A
R
A
N
Q
E
V
A
V
K
I
I
R
N
N
E
--
L
M
Q
K
T
G
L
K
E
L
E
F
L
K
K
L
N
D
A
D
P
D
D
K
F
H
C
L
R
L
F
-----
R
H
F
Y
H
K
Q
H
L
C
L
V
F
E
P
L
S
M
N
L
R
E
V
L
K
K
Y
G
K
D
V
G
L
H
I
K
A
V
R
S
Y
S
Q
Q
L
F
L
A
L
K
L
L
K
R
C
N
I
L
H
A
D
I
K
P
D
N
I
L
V
N
E
S
------------------------------
K
T
I
L
K
L
C
D
F
G
S
A
S
HV
A
D
N
D
I
T
P
Y
L
V
S
-
R
F
Y
R
A
P
E
I
I
I
G
-
K
S
Y
D
Y
G
I
D
M
W
S
V
G
C
T
L
Y
E
L
Y
T
G
K
I
L
F
P
G
K
T
N
N
H
M
L
K
L
A
M
D
L
K
G
K
M
P
N
K
M
I
---
R
K
G
V
F
---
K
D
Q
H
F
D
--
Q
-
N
--
L
N
F
M
Y
I
-
E
--------
R
E
K
V
T
V
--
M
--
S
----
T
-------------
I
N
P
T
-
K
D
L
L
A
D
LIL
P
E
--
D
Q
R
K
-----------
K
V
H
Q
L
K
-
D
L
L
D
Q
I
L
M
L
D
P
A
K
R
I
S
I
N
Q
A
L
Q
H
A
F
I
Q
E
------------------
14
PsiBlast_PDB
64.89
31%
-116
- C1 -
4IFC
1
PRP4B_HUMAN
A:
[15-348]
-------------------------------------------------------------------------------------------------------------------------------------------------
D
A
E
G
Y
Y
R
V
N
I
G
E
V
L
D
K
R
Y
N
V
Y
G
Y
T
G
Q
G
V
F
S
N
V
V
R
A
R
D
N
A
R
A
N
Q
E
V
A
V
K
I
I
R
N
N
E
--
L
M
Q
K
T
G
L
K
E
L
E
F
L
K
K
L
N
D
A
D
P
D
D
K
F
H
C
L
R
L
F
-----
R
H
F
Y
H
K
Q
H
L
C
L
V
F
E
P
L
S
M
N
L
R
E
V
L
K
K
Y
G
K
D
V
G
L
H
I
K
A
V
R
S
Y
S
Q
Q
L
F
L
A
L
K
L
L
K
R
C
N
I
L
H
A
D
I
K
P
D
N
I
L
V
N
E
S
------------------------------
K
T
I
L
K
L
C
D
F
G
S
A
S
HV
A
D
N
D
I
T
P
Y
L
V
S
-
R
F
Y
R
A
P
E
I
I
I
G
-
K
S
Y
D
Y
G
I
D
M
W
S
V
G
C
T
L
Y
E
L
Y
T
G
K
I
L
F
P
G
K
T
N
N
H
M
L
K
L
A
M
D
L
K
G
K
M
P
N
K
M
I
---
R
K
G
V
F
---
K
D
Q
H
F
D
--
Q
-
N
--
L
N
F
M
Y
I
-
E
--------
R
E
K
V
T
V
--
M
--
S
----
T
-------------
I
N
P
T
-
K
D
L
L
A
D
LIL
P
E
--
D
Q
R
K
-----------
K
V
H
Q
L
K
-
D
L
L
D
Q
I
L
M
L
D
P
A
K
R
I
S
I
N
Q
A
L
Q
H
A
F
I
Q
E
------------------
16
PsiBlast_PDB
64.04
31%
-116
- C1 -
4IJP
1
PRP4B_HUMAN
A:
[15-348]
-------------------------------------------------------------------------------------------------------------------------------------------------
D
A
E
G
Y
Y
R
V
N
I
G
E
V
L
D
K
R
Y
N
V
Y
G
Y
T
G
Q
G
V
F
S
N
V
V
R
A
R
D
N
A
R
A
N
Q
E
V
A
V
K
I
I
R
N
N
E
--
L
M
Q
K
T
G
L
K
E
L
E
F
L
K
K
L
N
D
A
D
P
D
D
K
F
H
C
L
R
L
F
-----
R
H
F
Y
H
K
Q
H
L
C
L
V
F
E
P
L
S
M
N
L
R
E
V
L
K
K
Y
G
K
D
V
G
L
H
I
K
A
V
R
S
Y
S
Q
Q
L
F
L
A
L
K
L
L
K
R
C
N
I
L
H
A
D
I
K
P
D
N
I
L
V
N
E
S
------------------------------
K
T
I
L
K
L
C
D
F
G
S
A
S
HV
A
D
N
D
I
T
P
Y
L
V
S
-
R
F
Y
R
A
P
E
I
I
I
G
-
K
S
Y
D
Y
G
I
D
M
W
S
V
G
C
T
L
Y
E
L
Y
T
G
K
I
L
F
P
G
K
T
N
N
H
M
L
K
L
A
M
D
L
K
G
K
M
P
N
K
M
I
---
R
K
G
V
F
---
K
D
Q
H
F
D
--
Q
-
N
--
L
N
F
M
Y
I
-
E
V
D
-----
E
R
E
K
V
T
V
--
M
--
S
----
T
-------------
I
N
P
T
-
K
D
L
L
A
D
LIQRL
P
E
D
Q
R
K
-----------
K
V
H
Q
L
K
-
D
L
L
D
Q
I
L
M
L
D
P
A
K
R
I
S
I
N
Q
A
L
Q
H
A
F
I
Q
E
------------------
12
PsiBlast_PDB
61.45
31%
-106
- C1 -
4AZF
2
DYRK2_HUMAN
A:
[81-413]
------------------------------------------------------------------------------------------------------------------------------------------------
D
D
D
Q
G
S
Y
V
Q
V
P
H
D
H
V
A
Y
R
Y
E
V
L
K
V
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
H
K
V
H
-
Q
H
V
A
L
K
M
V
R
N
E
K
--
R
F
H
R
Q
A
A
E
E
I
R
I
L
E
H
L
R
K
Q
D
K
D
N
T
M
N
V
I
H
M
L
-----
E
N
F
T
F
R
N
H
I
C
M
T
F
E
L
L
S
M
N
L
Y
E
L
I
K
K
-
N
K
F
Q
G
F
S
L
P
L
V
R
K
F
A
H
S
I
L
Q
C
L
D
A
L
H
K
N
R
I
I
H
C
D
L
K
P
E
N
I
L
L
---------------
K
Q
Q
G
R
-----
S
---------
G
I
K
V
I
D
F
G
S
S
C
--
Y
E
H
Q
R
V
Y
T
Y
I
Q
S
R
F
Y
R
A
P
E
V
I
L
G
-
A
R
Y
G
M
P
I
D
M
W
S
L
G
C
I
L
A
E
L
L
T
G
Y
P
L
L
P
G
E
D
E
G
D
Q
L
A
C
M
I
E
L
L
G
M
P
S
Q
K
L
L
---
D
A
-
S
K
---
R
A
K
N
F
V
SS
K
-
G
YP
R
----
Y
-
C
T
V
--
T
T
L
S
D
--
V
-
V
--
L
--
N
----
G
-------------
G
R
S
R
-
R
G
K
L
R
--------
G
P
P
E
S
R
E
W
G
N
ALKGC
D
D
P
L
F
L
-
D
F
L
K
Q
C
L
E
W
D
P
A
V
R
M
T
P
G
Q
A
L
R
H
P
W
L
R
-------------------
10
PsiBlast_PDB
61.20
31%
-103
- C1 -
3KVW
1
DYRK2_HUMAN
A:
[81-413]
------------------------------------------------------------------------------------------------------------------------------------------------
D
D
D
Q
G
S
Y
V
Q
V
P
H
D
H
V
A
Y
R
Y
E
V
L
K
V
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
H
K
V
H
-
Q
H
V
A
L
K
M
V
R
N
E
K
--
R
F
H
R
Q
A
A
E
E
I
R
I
L
E
H
L
R
K
Q
D
K
D
N
T
M
N
V
I
H
M
L
-----
E
N
F
T
F
R
N
H
I
C
M
T
F
E
L
L
S
M
N
L
Y
E
L
I
K
K
-
N
K
F
Q
G
F
S
L
P
L
V
R
K
F
A
H
S
I
L
Q
C
L
D
A
L
H
K
N
R
I
I
H
C
D
L
K
P
E
N
I
L
L
---------------
K
Q
Q
G
R
-----
S
---------
G
I
K
V
I
D
F
G
S
S
C
--
Y
E
H
Q
R
V
Y
T
Y
I
Q
S
R
F
Y
R
A
P
E
V
I
L
G
-
A
R
Y
G
M
P
I
D
M
W
S
L
G
C
I
L
A
E
L
L
T
G
Y
P
L
L
P
G
E
D
E
G
D
Q
L
A
C
M
I
E
L
L
G
M
P
S
Q
K
L
L
---
D
A
-
S
K
---
R
A
K
N
F
V
SS
K
-
G
YP
R
----
Y
-
C
T
V
--
T
T
L
S
D
--
V
-
V
--
L
--
N
----
G
-------------
G
R
S
R
-
R
G
K
L
R
--------
G
P
P
E
S
R
E
W
G
N
ALKGC
D
D
P
L
F
L
-
D
F
L
K
Q
C
L
E
W
D
P
A
V
R
M
T
P
G
Q
A
L
R
H
P
W
L
R
-------------------
56
HHSearch
58.26
31%
-117
- C1 -
2B9H
1
FUS3_YEAST
A:
[9-313]
--------------------------------------------------------------------------------------------------------------------------------------------------------------
I
S
S
D
F
Q
L
K
S
L
L
G
E
G
A
Y
G
V
V
C
S
A
T
H
K
-
P
T
G
E
I
V
A
I
K
K
I
E
P
F
D
K
P
L
F
A
L
R
T
L
R
E
I
K
I
L
K
H
F
K
H
--
E
-
N
---
I
I
T
I
F
NIQRP
D
S
F
E
N
F
N
E
V
Y
I
I
Q
E
L
M
Q
T
D
L
H
R
V
I
S
T
-
Q
---
M
L
S
D
D
H
I
Q
Y
F
I
Y
Q
T
L
R
A
V
K
V
L
H
G
S
N
V
I
H
R
D
L
K
P
S
N
L
L
I
N
S
-------------------------------
N
C
D
L
K
V
C
D
F
G
L
A
R
--
I
I
D
---
V
E
F
V
A
T
R
W
Y
R
A
P
E
V
M
L
T
S
A
K
Y
S
R
A
M
D
V
W
S
C
G
C
I
L
A
E
L
F
L
R
R
P
I
F
P
G
R
D
Y
R
H
Q
L
L
L
I
F
G
I
I
G
T
P
H
S
D
-----------------------
N
--
D
----
L
-
R
C
I
--
E
S
P
R
A
R
E
Y
-
I
--
K
--
S
LPMY
P
-------------
A
A
P
L
-
E
K
M
F
P
--------
R
--------------
V
N
P
K
G
I
-
D
L
L
Q
R
M
L
V
F
D
P
A
K
R
I
T
A
K
E
A
L
E
H
P
Y
L
Q
T
Y
H
D
P
N
D
E
P
E
G
E
P
I
P
P
S
F
F
44
HHSearch
58.12
30%
-118
- C1 -
4BGQ
3
CDKL5_HUMAN
A:
[10-300]
-------------------------------------------------------------------------------------------------------------------------------------------------------------
V
M
-
N
K
F
E
I
L
G
V
V
G
E
G
A
Y
G
V
V
L
K
C
R
H
K
E
-
T
H
E
I
V
A
I
K
K
F
K
------
V
K
E
T
T
L
R
E
L
K
M
L
R
T
L
K
Q
--
E
----
N
I
V
E
L
K
-----
E
A
F
R
R
R
G
K
L
Y
L
V
F
E
Y
V
E
K
N
M
L
E
L
L
E
E
-
M
P
-
N
G
V
P
P
E
K
V
K
S
Y
I
Y
Q
L
I
K
A
I
H
W
C
H
K
N
D
I
V
H
R
D
I
K
P
E
N
L
L
I
S
H
-------------------------------
N
D
V
L
K
L
C
D
F
G
F
A
R
--
N
L
S
E
-------
T
R
W
Y
R
S
P
E
L
L
L
G
-
A
P
Y
G
K
S
V
D
M
W
S
V
G
C
I
L
G
E
L
S
D
G
Q
P
L
F
P
G
E
S
E
I
D
Q
L
F
T
I
Q
K
V
L
G
P
L
P
S
E
Q
M
---
K
L
-
F
Y
---
S
N
P
R
F
H
--
G
---------
L
-
R
F
P
--
A
V
N
H
P
------------------------------
Q
S
L
E
R
R
Y
L
G
--------
I
--------------
L
N
S
V
L
L
-
D
L
M
K
N
L
L
K
L
D
P
A
D
R
Y
L
T
E
Q
C
L
N
H
P
T
F
Q
T
Q
R
L
---------------