@TOME V2.3
(Nov 2016)

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Alignment:

3D Common Core:

Structural Clustering:

Modeller Result :

Complexes Modeling
Templates Information:
Sequence & Result Tab:

Values color: [ Good | Correct | Middling | Bad ]Sequence color : MutatedHelixStrandConserved

Query sequence : CLK4_HUMAN: (2015-10-05 )
MRHSKRTHCPDWDSRESWGHESYRGSHKRKRRSHSSTQENRHCKPHHQFKESDCHYLEARSLNERDYRDRRYVDEYRNDYCEGYVPRHYHRDIESGYRIHCSKSSVRSRRSSPKRKRNRHCSSHQSRSKSHRRKRSRSIEDDEEGHLICQSGDVLRARYEIVDTLGEGAFGKVVECIDHGMDGMHVAVKIVKNVGRYREAARSEIQVLEHLNSTDPNSVFRCVQMLEWFDHHGHVCIVFELLGLSTYDFIKENSFLPFQIDHIRQMAYQICQSINFLHHNKLTHTDLKPENILFVKSDYVVKYNSKMKRDERTLKNTDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFQTHDSKEHLAMMERILGPIPQHMIQKTRKRKYFHHNQLDWDEHSSAGRYVRRRCKPLKEFMLCHDEEHEKLFDLVRRMLEYDPTQRITLDEALQHPFFDLLKKK

Atome Classification :

(20 SA) .........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.---.--.--....200.......210.......-220.......230---..------.......240.......250..-.....260.......270.......280.......290.-----......300.......--310-.-----.......320.......-330--........340.......350.-.......360.......370.......380.......390.......400--....---..-.-.410--....-----------.-.-----.--..420...-..--.-----.----430--.....----.-------...440--.----......450.......460.......470.......480
(Atome) (Ident) (Tito) (Num) (Ligand) (Uniprot) MRHSKRTHCPDWDSRESWGHESYRGSHKRKRRSHSSTQENRHCKPHHQFKESDCHYLEARSLNERDYRDRRYVDEYRNDYCEGYVPRHYHRDIESGYRIHCSKSSVRSRRSSPKRKRNRHCSSHQSRSKSHRRKRSRSIEDDEEGHLICQSGDVLRARYEIVDTLGEGAFGKVVECIDHGMDGMHVAVKIVKN---V--G--RYREAARSEIQVLEHLNSTDPNSV-FRCVQMLEWFD-----HH------GHVCIVFELLGLSTYDFIKENS-FLPFQIDHIRQMAYQICQSINFLHHNKLTHTDLKPENIL-----FVKSDYVVKYNSKMKR--DE--R-----TLKNTDIKVVDFGSATY-DD---EHHSTLVSTRHYRAPEVILA-L-GWSQPCDVWSIGCILIEYYLGFTVFQTHDSKEHLAMMERILGPIPQHMI---QKTR---KR-K-YF----HHNQ-----------L-D-----W--DEHSSAGR-YV--R-----R----R----CKPLK----E-------FMLCHD--E----EHEKLFDLVRRMLEYDPTQRITLDEALQHPFFDLLKKK
34 HHSearch 92.2387%-120 - C1 -1Z57 CLK1_HUMAN A:[2-337] ------------------------------------------------------------------------------------------------------------------------------------------------MHLICQSGDVLSARYEIVDTLGEGAFGKVVECIDHKAGGRHVAVKIVKN---V--D--RYCEAARSEIQVLEHLNTTDPNST-FRCVQMLEWFE-----HH------GHICIVFELLGLSTYDFIKENG-FLPFRLDHIRKMAYQICKSVNFLHSNKLTHTDLKPENIL-----FVQSDYTEAYN----R--DE--R-----TLINPDIKVVDFGSATY-DD---EHHSTLVSTRHYRAPEVILA-L-GWSQPCDVWSIGCILIEYYLGFTVFPTHDSKEHLAMMERILGPLPKHMI---QKTR---KR-K-YF----HHDR-----------L-D-----W--DEHSSAGR-YV--S-----R----A----CKPLK----E-------FMLSQD--V----EHERLFDLIQKMLEYDPAKRITLREALKHPFFDLLKK-
1 PsiBlast_PDB 92.1986%-122 - C1 -1Z57 CLK1_HUMAN A:[3-337] -------------------------------------------------------------------------------------------------------------------------------------------------HLICQSGDVLSARYEIVDTLGEGAFGKVVECIDHKAGGRHVAVKIVKN---V--D--RYCEAARSEIQVLEHLNTTDPNST-FRCVQMLEWFE-----HH------GHICIVFELLGLSTYDFIKENG-FLPFRLDHIRKMAYQICKSVNFLHSNKLTHTDLKPENIL-----FVQSDYTEAYN----R--DE--R-----TLINPDIKVVDFGSATY-DD---EHHSTLVSTRHYRAPEVILA-L-GWSQPCDVWSIGCILIEYYLGFTVFPTHDSKEHLAMMERILGPLPKHMI---QKTR---KR-K-YF----HHDR-----------L-D-----W--DEHSSAGR-YV--S-----R----A----CKPLK----E-------FMLSQD--V----EHERLFDLIQKMLEYDPAKRITLREALKHPFFDLLKK-
2 PsiBlast_PDB 92.0886%-125 - C1 -2VAG CLK1_HUMAN A:[3-336] -------------------------------------------------------------------------------------------------------------------------------------------------HLICQSGDVLSARYEIVDTLGEGAFGKVVECIDHKAGGRHVAVKIVKN---V--D--RYCEAARSEIQVLEHLNTTDPNST-FRCVQMLEWFE-----HH------GHICIVFELLGLSTYDFIKENG-FLPFRLDHIRKMAYQICKSVNFLHSNKLTHTDLKPENIL-----FVQSDYTEAYN---KR--DE--R-----TLINPDIKVVDFGSATY-DD---EHHSTLVSTRHYRAPEVILA-L-GWSQPCDVWSIGCILIEYYLGFTVFPTHDSKEHLAMMERILGPLPKHMI---QKTR---KR-K-YF----HHDR-----------L-D-----W--DEHSSAGR-YV--S-----R----A----CKPLK----E-------FMLSQD--V----EHERLFDLIQKMLEYDPAKRITLREALKHPFFDLLK--
22 PsiBlast_CBE 90.2666%-118 - C1 -3NR9 CLK2_HUMAN B:[15-354] ------------------------------------------------------------------------------------------------------------------------------------------VEDDAEGHLIYHVGDWLQERYEIVSTLGEGTFGRVVQCVDHRRGGARVALKIIKN---V--E--KYKEAARLEINVLEKINEKDPDNK-NLCVQMFDWFD-----YH------GHMCISFELLGLSTFDFLKDNN-YLPYPIHQVRHMAFQLCQAVKFLHDNKLTHTDLKPENIL-----FVNSDYELTYNLEKKR--DE--R-----SVKSTAVRVVDFGSATF-DH---EHHSTIVSTRHYRAPEVILE-L-GWSQPCDVWSIGCIIFEYYVGFTLFQTHDNREHLAMMERILGPIPSRMI---RKTR---KQ-K-YF----YRGR-----------L-D-----W--DENTSAGR-YV--R-----E----N----CKPLR----R-------YLTSEA--E----EHHQLFDLIESMLEYEPAKRLTLGEALQHPFFARL---
3 PsiBlast_PDB 90.0966%-120 - C1 -3NR9 CLK2_HUMAN A:[15-356] ------------------------------------------------------------------------------------------------------------------------------------------VEDDAEGHLIYHVGDWLQERYEIVSTLGEGTFGRVVQCVDHRRGGARVALKIIKN---V--E--KYKEAARLEINVLEKINEKDPDNK-NLCVQMFDWFD-----YH------GHMCISFELLGLSTFDFLKDNN-YLPYPIHQVRHMAFQLCQAVKFLHDNKLTHTDLKPENIL-----FVNSDYELT---------DE--R-----SVKSTAVRVVDFGSATF-DH---EHHSTIVSTRHYRAPEVILE-L-GWSQPCDVWSIGCIIFEYYVGFTLFQTHDNREHLAMMERILGPIPSRMI---RKTR---KQ-K-YF----YRGR-----------L-D-----W--DENTSAGR-YV--R-----E----N----CKPLR----R-------YLTSEA--E----EHHQLFDLIESMLEYEPAKRLTLGEALQHPFFARLRA-
21 PsiBlast_CBE 89.4866%-119 - C1 -3NR9 CLK2_HUMAN C:[15-355] ------------------------------------------------------------------------------------------------------------------------------------------VEDDAEGHLIYHVGDWLQERYEIVSTLGEGTFGRVVQCVDHRRGGARVALKIIKN---V--E--KYKEAARLEINVLEKINEKDPDNK-NLCVQMFDWFD-----YH------GHMCISFELLGLSTFDFLKDNN-YLPYPIHQVRHMAFQLCQAVKFLHDNKLTHTDLKPENIL-----FVNSDYELTYNLEKKR--DE--R-----SVKSTAVRVVDFGSATF-DH---EHHSTIVSTRHYRAPEVILE-L-GWSQPCDVWSIGCIIFEYYVGFTLFQTHDNREHLAMMERILGPIPSRMI---RKTR---KQ-K-YF----YRGR-----------L-D-----W--DENTSAGR-YV--R-----E----N----CKPLR----R-------YLTSEA--E----EHHQLFDLIESMLEYEPAKRLTLGEALQHPFFARLR--
4 PsiBlast_PDB 87.6362%-117 - C1 -2WU6 CLK3_HUMAN A:[31-369] ----------------------------------------------------------------------------------------------------------------------------------------RSVEDDKEGHLVCRIGDWLQERYEIVGNLGEGTFGKVVECLDHARGKSQVALKIIRN---V--G--KYREAARLEINVLKKIKEKDKENK-FLCVLMSDWFN-----FH------GHMCIAFELLGKNTFEFLKENN-FQPYPLPHVRHMAYQLCHALRFLHENQLTHTDLKPENIL-----FVNSEFETLYNEHKSC--EE--K-----SVKNTSIRVADFGSATF-DH---EHHTTIVATRHYRPPEVILE-L-GWAQPCDVWSIGCILFEYYRGFTLFQTHENREHLVMMEKILGPIPSHMI---HRTR---KQ-K-YF----YKGG-----------L-V-----W--DENSSDGR-YV--K-----E----N----CKPLK----S-------YMLQDS--L----EHVQLFDLMRRMLEFDPAQRITLAEALLHPFFAGLTPE
6 PsiBlast_PDB 86.5362%-115 - C1 -3RAW CLK3_HUMAN A:[31-369] ----------------------------------------------------------------------------------------------------------------------------------------RSVEDDKEGHLVCRIGDWLQERYEIVGNLGEGTFGKVVECLDHARGKSQVALKIIRN---V--G--KYREAARLEINVLKKIKEKDKENK-FLCVLMSDWFN-----FH------GHMCIAFELLGKNTFEFLKENN-FQPYPLPHVRHMAYQLCHALRFLHENQLTHTDLKPENIL-----FVNSEFETLYNEHKSC--EE--K-----SVKNTSIRVADFGSATF-DH---EHHTTIVATRHYRPPEVILE-L-GWAQPCDVWSIGCILFEYYRGFTLFQTHENREHLVMMEKILGPIPSHMI---HRTR---KQ-K-YF----YKGG-----------L-V-----W--DENSSDGR-YV--K-----E----N----CKPLK----S-------YMLQDS--L----EHVQLFDLMRRMLEFDPAQRITLAEALLHPFFAGLTPE
23 PsiBlast_CBE 85.3662%-114 - C1 -3RAW CLK3_HUMAN B:[33-369] ------------------------------------------------------------------------------------------------------------------------------------------VEDDKEGHLVCRIGDWLQERYEIVGNLGEGTFGKVVECLDHARGKSQVALKIIRN---V--G--KYREAARLEINVLKKIKEKDKENK-FLCVLMSDWFN-----FH------GHMCIAFELLGKNTFEFLKENN-FQPYPLPHVRHMAYQLCHALRFLHENQLTHTDLKPENIL-----FVNSEFETLYNEHKSC--EE--K-----SVKNTSIRVADFGSATF-DH---EHHTTIVATRHYRPPEVILE-L-GWAQPCDVWSIGCILFEYYRGFTLFQTHENREHLVMMEKILGPIPSHMI---HRTR---KQ-K-YF----YKGG-----------L-V-----W--DENSSDGR-YV--K-----E----N----CKPLK----S-------YMLQDS--L----EHVQLFDLMRRMLEFDPAQRITLAEALLHPFFAGLTPE
5 PsiBlast_PDB 84.4462%-118 - C1 -2WU7 CLK3_HUMAN A:[32-369] -----------------------------------------------------------------------------------------------------------------------------------------SVEDDKEGHLVCRIGDWLQERYEIVGNLGEGTFGKVVECLDHARGKSQVALKIIRN---V--G--KYREAARLEINVLKKIKEKDKENK-FLCVLMSDWFN-----FH------GHMCIAFELLGKNTFEFLKENN-FQPYPLPHVRHMAYQLCHALRFLHENQLTHTDLKPENIL-----FVNSEFETLYNEHKSC--EE--K-----SVKNTSIRVADFGSATF-DH---EHHTTIVATRHYRPPEVILE-L-GWAQPCDVWSIGCILFEYYRGFTLFQTHENREHLVMMEKILGPIPSHMI---HRTR---KQ-K-YF----YKGG-----------L-V-----W--DENSSDGR-YV--K-----E----N----CKPLK----S-------YMLQDS--L----EHVQLFDLMRRMLEFDPAQRITLAEALLHPFFAGLTPE
36 HHSearch 70.4437%-114 - C1 -3LLT ? A:[20-360] ---------------------------------------------------------------------------------------------------------------------------------------------DEIVHFSWKKGMLLNNAFLVIRKMGDGTFGRVLLCQHI-DNKKYYAVKVVRN---I--K--KYTRSAKIEADILKKIQNDDINN--NNIVKYHGKFM-----YY------DHMCLIFEPLGPSLYEIITRNN-YNGFHIEDIKLYCIEILKALNYLRKMSLTHTDLKPENIL-----LDDPYF-EKSLITVRRVTDG--KKIQIYRTKSTGIKLIDFGCATF-KS---DYHGSIINTRQYRAPEVILN-L-GWDVSSDMWSFGCVLAELYTGSLLFRTHEHMEHLAMMESIIQPIPKNML---YEATKTNGS-K-YV----NKDELK---------L-A-----W--PENASSIN-SIKHV-----K----K----CLPLY----K-------II-----------KHELFCDFLYSILQIDPTLRPSPAELLKHKFLE-----
9 PsiBlast_PDB 68.9937%-111 - C1 -3LLT ? A:[20-360] ---------------------------------------------------------------------------------------------------------------------------------------------DEIVHFSWKKGMLLNNAFLVIRKMGDGTFGRVLLC-QHIDNKKYYAVKVVRN---I--K--KYTRSAKIEADILKKIQNDD-INN-NNIVKYHGKFM-----YY------DHMCLIFEPLGPSLYEIITRNN-YNGFHIEDIKLYCIEILKALNYLRKMSLTHTDLKPENILLDDPYFEKSLITVRRVTDGKK--IQIYR-----T-KSTGIKLIDFGCATF-KS---DYHGSIINTRQYRAPEVILN-L-GWDVSSDMWSFGCVLAELYTGSLLFRTHEHMEHLAMMESIIQPIPKNMLYEATKTN---GS-K-YV----NKDE-----------L-KLA---W--PENASSIN-SI--KHV---K----K----CLPLY----K-------II-----------KHELFCDFLYSILQIDPTLRPSPAELLKHKFLE-----
39 HHSearch 68.0936%-111 - C1 -3KVW DYRK2_HUMAN A:[80-413] -------------------------------------------------------------------------------------------------------------------------------------------YDDDQGSYVQVPHDHVAYRYEVLKVIGKGSFGQVVKAYDHK-VHQHVALKMVRN---E--K--RFHRQAAEEIRILEHLRKQDKDNT-MNVIHMLENFT-----FR------NHICMTFELLSMNLYELIKKNK-FQGFSLPLVRKFAHSILQCLDALHKNRIIHCDLKPENIL-----LKQQG--------------------------RSGIKVIDFGSSCY-EH---QRVYTYIQSRFYRAPEVILG-A-RYGMPIDMWSLGCILAELLTGYPLLPGEDEGDQLACMIELLGMPSQKLL---DASK---RA-KNFV----SSKG-----------YPR-----YCTVTTLSD---VV--LNGGRSRRGKLRGPPESREWG----N-------ALK--G--C----DDPLFLDFLKQCLEWDPAVRMTPGQALRHPWLR-----
40 HHSearch 66.1732%-109 - C1 -4IIR PRP4B_HUMAN A:[13-350] -------------------------------------------------------------------------------------------------------------------------------------------WTDAEGYYRVNIGEVLDKRYNVYGYTGQG--SNVVRARDNARANQEVAVKIIRN---N--E--LMQKTGLKELEFLKKLNDADPDDK-FHCLRLFRHFY-----HK------QHLCLVFEPLSMNLREVLKKYGKDVGLHIKAVRSYSQQLFLALKLLKRCNILHADIKPDNIL-----VNES---------------------------KTILKLCDFGSASHVAD---NDITPYLVSRFYRAPEIIIG-K-SYDYGIDMWSVGCTLYELYTGKILFPGKTNNHMLKLAMDLKGKMPNKMI---RKGV---FKDQ-HF----DQ-N-----------L-NFMYIE--------REKVTV--M-----S----T----INPTKDLLAD-------LI----LPEDQRKKVHQLKDLLDQILMLDPAKRISINQALQHAFIQE----
10 PsiBlast_PDB 64.8633%-106 - C1 -3KVW DYRK2_HUMAN A:[81-412] --------------------------------------------------------------------------------------------------------------------------------------------DDDQGSYVQVPHDHVAYRYEVLKVIGKGSFGQVVKAYDHKVH-QHVALKMVRN---E--K--RFHRQAAEEIRILEHLRKQDKDNT-MNVIHMLENFT-----FR------NHICMTFELLSMNLYELIKKNK-FQGFSLPLVRKFAHSILQCLDALHKNRIIHCDLKPENIL------------------LKQ--QG--R---------SGIKVIDFGSSCY-EH---QRVYTYIQSRFYRAPEVILG-A-RYGMPIDMWSLGCILAELLTGYPLLPGEDEGDQLACMIELLGMPSQKLL---DASK---RA-K-NF----VSSKGYPRYCTVTTLS-D---------VVLNGGR-SR--R-----G----K----LRGPP----ESREWGNALKGCDD---------PLFLDFLKQCLEWDPAVRMTPGQALRHPWLR-----
11 PsiBlast_PDB 63.6033%-106 - C1 -4AZF DYRK2_HUMAN A:[81-412] --------------------------------------------------------------------------------------------------------------------------------------------DDDQGSYVQVPHDHVAYRYEVLKVIGKGSFGQVVKAYDHKVH-QHVALKMVRN---E--K--RFHRQAAEEIRILEHLRKQDKDNT-MNVIHMLENFT-----FR------NHICMTFELLSMNLYELIKKNK-FQGFSLPLVRKFAHSILQCLDALHKNRIIHCDLKPENIL------------------LKQ--QG--R---------SGIKVIDFGSSCY-EH---QRVYTYIQSRFYRAPEVILG-A-RYGMPIDMWSLGCILAELLTGYPLLPGEDEGDQLACMIELLGMPSQKLL---DASK---RA-K-NF----VSSKGYPRYCTVTTLS-D---------VVLNGGR-SR--R-----G----K----LRGPP----ESREWGNALKGCDD---------PLFLDFLKQCLEWDPAVRMTPGQALRHPWLR-----
54 HHSearch 61.9334%-111 - C1 -2B9H FUS3_YEAST A:[6-312] -------------------------------------------------------------------------------------------------------------------------------------------------------VYNISSDFQLKSLLGEGAYGVVCSATHK-PTGEIVAIKKIEP---F--DKPLFALRTLREIKILKHFKH--ENIITIFNIQRPDSFE-----NF------NEVYIIQELMQTDLHRVISTQ----MLSDDHIQYFIYQTLRAVKVLHGSNVIHRDLKPSNLL-----IN----------------------------SNCDLKVCDFGLARI-ID------VEFVATRWYRAPEVMLTSA-KYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTPHSD-------------------------ND-----------L-R-----C--IESPRARE-YI--K-----SLPMYP----AAPLE----K-------MFPR---------VNPKGIDLLQRMLVFDPAKRITAKEALEHPYLQTYHDP
49 HHSearch 60.3230%-120 - C1 -4QNY ? A:[18-315] ----------------------------------------------------------------------------------------------------------------------------------------------------------LDDRYLLERIIGAGSYGVVIRARDTKSDNRLVAMKRVNK---EIFEEVILAKRILREIKLLAHFND--DN-----IIGLRNILTPEDPENF------DHFYIVMDIMETDLKQVLRSGQ---ELTEAHIQFFIYQALRALHIIHSAGVIHRDITPANIL-----VN----------------------------TNCDLKICDFGLAKE-E-G--EYMTDYVTMRWYRAPELVMEDK-DYSAQIDVWGIGCILGELLGSRPLFQGKDRVNQLDKIVDVIGTPSEEDI---NSVGSSAAQ-K-YLKKKSHRPQ-----------A-D-----W--R-------------------------------------Q-------RY---P--T----ASPEALDLLRHMLVFNPKRRITVLQAMRHPFLEQLHDD
46 HHSearch 58.1230%-122 - C1 -1CM8 MK12_HUMAN A:[23-315] ----------------------------------------------------------------------------------------------------------------------------------------------------------VRAVYRDLQPV------AVCSAVDG-RTGAKVAIKKLYRPFQS--E--LFAKRAYRELRLLKHMRH--EN-----VIGLLDVFT-----PDETLDDFTDFYLVMPFMGTDLGKLMKHE----KLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLA-----VNE----------------------------DCELKILDFGLARQ-AD---SEMTGYVVTRWYRAPEVILNWM-RYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFV---QRLQ---SD---------------------------------------EAKN-YM--K-----GLPELE----KKDFA----S-------ILT-----N----ASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHQV
45 HHSearch 52.5031%-107 - C1 -1UA2 CDK7_HUMAN A:[13-297] ---------------------------------------------------------------------------------------------------------------------------------------------------------------EKLDFLGEGQFATVYKARDK-NTNQIVAIKKI-------------NRTALREIKLLQELS--HPN-----IIGLLDAFG-----HK------SNISLVFDFMETDLEVIIKDNS--LVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLL-----LD----------------------------ENGVLKLADFGLAKS-FGSPNRAYTHQVVTRWYRAPELLFG-ARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEE----------------------------------------Q-----W--PDMCSLPD-YV--T-----F----KSFP-GIPLH----H-------IFSA---------AGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGP