@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : CSKP_HUMAN: (2015-10-06 )
MADDDVLFEDVYELCEVIGKGPFSVVRRCINRETGQQFAVKIVDVAKFTSSPGLSTEDLKREASICHMLKHPHIVELLETYSSDGMLYMVFEFMDGADLCFEIVKRADAGFVYSEAVASHYMRQILEALRYCHDNNIIHRDVKPHCVLLASKENSAPVKLGGFGVAIQLGESGLVAGGRVGTPHFMAPEVVKREPYGKPVDVWGCGVILFILLSGCLPFYGTKERLFEGIIKGKYKMNPRQWSHISESAKDLVRRMLMLDPAERITVYEALNHPWLKERDRYAYKIHLPETVEQLRKFNARRKLKGAVLAAVSSHKFNSFYGDPPEELPDFSEDPTSSGLLAAERAVSQVLDSLEEIHALTDCSEKDLDFLHSVFQDQHLHTLLDLYDKINTKSSPQIRNPPSDAVQRAKEVLEEISCYPENNDAKELKRILTQPHFMALLQTHDVVAHEVYSDEALRVTPPPTSPYLNGDSPESANGDMDMENVTRVRLVQFQKNTDEPMGITLKMNELNHCIVARIMHGGMIHRQGTLHVGDEIREINGISVANQTVEQLQKMLREMRGSITFKIVPSYRTQSSSCERDSPSTSRQSPANGHSSTNNSVSDLPSTTQPKGRQIYVRAQFEYDPAKDDLIPCKEAGIRFRVGDIIQIISKDDHNWWQGKLENSKNGTAGLIPSPELQEWRVACIAMEKTKQEQQASCTWFGKKKKQYKDKYLAKHNAVFDQLDLVTYEEVVKLPAFKRKTLVLLGAHGVGRRHIKNTLITKHPDRFAYPIPHTTRPPKKDEENGKNYYFVSHDQMMQDISNNEYLEYGSHEDAMYGTKLETIRKIHEQGLIAILDVEPQALKVLRTAEFAPFVVFIAAPTITPGLNEDESLQRLQKESDILQRTYAHYFDLTIINNEIDETIRHLEEAVELVCTAPQWVPVSWVY
Atome Classification :
(46 SA)
.........10........20........30........40........50-.-.......60-.....--....70---.........80........90........100...----------------------------------....110.......120.......130.......140.......150.-....-..160.......170-........180.......190------.--......200.......210.......220.-.--.-.-.-...230.......240.......250.......260.......270.......280----...--......290--.-......300.......310........320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770.......780.......790.......800.......810.......820.......830.......840.......850.......860.......870.......880.......890.......900.......910.......920....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MAD
D
D
V
L
F
E
D
V
Y
E
L
C
E
V
IGKG
P
F
S
V
V
R
R
C
I
N
R
ET
G
Q
Q
F
A
V
K
I
V
D
V
A
K
FTSS-P-GL
S
T
E
D
L
K
--
R
E
A
S
I
--
C
H
M
LK----H
P
H
I
V
E
L
L
E
T
YSSD
G
M
L
Y
M
V
F
E
FMD
G
A
D
L
C
F
E
I
V
K
----------------------------------RADAG
F
V
Y
S
E
A
V
A
S
H
Y
M
R
Q
I
L
E
A
L
R
Y
C
HDNNIIHRDVKP
H
C
V
L
L
ASKE-NSA
P
-
V
K
LG
G
F
G
V
A
I
Q
LGE--SGLVAGGRVGTPHFMA
P
E
V
V
K------R--EPYGKPVDV
W
G
C
G
V
I
L
F
I
L
L
SGCLPFYG-
T
-
K
--
E
-
R
-
L
-
F
E
G
I
IKGKYKM
N
P
R
Q
W
S
H
I
S
E
S
A
K
D
L
V
R
R
M
L
MLDPA
E
R
I
T
V
Y
E
ALNH
P
W
L
K
ERD------
R
Y
A
--
Y
K
I
H
L
P
E
T
V
--
E
-
Q
L
R
K
F
N
A
R
R
K
L
K
G
A
V
L
A
-
A
V
SSHKFNSFYGD
P
P
E
ELPDFSEDPTSS
G
L
L
A
A
E
R
A
V
S
Q
V
L
D
S
L
E
E
I
H
A
LTDCSEK
D
L
D
F
L
H
S
V
F
QD
Q
H
L
H
T
L
L
D
L
Y
D
KINTKSSPQIRNP
P
S
D
A
V
Q
R
A
K
E
V
L
E
E
ISCYPENN
D
A
K
E
L
K
R
I
LT
Q
P
H
F
M
A
L
L
Q
T
H
D
V
V
A
H
EVYSDE
A
L
R
VTPPPTSPYLNGDSPESANGDM
D
M
E
N
V
T
R
V
R
L
V
Q
F
QKNTDEP
M
G
I
T
L
K
M
N
E
L
N
H
C
I
V
A
R
I
M
HG
G
M
I
HRQG
T
L
HVGD
E
I
R
EINGI
S
V
A
N
Q
T
V
E
Q
L
Q
K
M
L
R
E
MRG
S
I
T
F
K
I
VPSYRTQSSSCERDSPSTSRQSPANGHSSTNNSVSDLPSTTQPKG
R
Q
I
Y
V
R
A
Q
F
EYDPAKDDLI
P
C
K
EA
G
I
R
F
R
V
G
D
I
I
Q
I
I
SKDDHNWWQGKLENSKNGTAGLIPS
P
E
L
Q
E
W
R
V
A
C
I
A
M
E
KT
K
Q
E
Q
QASCTWFG
K
K
K
K
Q
Y
K
D
K
Y
L
A
K
H
N
A
V
F
D
Q
L
D
L
V
T
Y
E
E
V
V
KLPAFK
R
K
T
L
V
L
L
GAHGV
G
R
R
H
I
K
N
T
LITKHPDRFAYPIPHTTRPPKKDEENGK
N
Y
Y
F
V
S
H
D
Q
M
M
Q
D
ISNNE
Y
L
EYGSHEDAMYG
T
K
L
E
T
I
R
K
I
H
EQG
L
I
A
I
L
DV
E
P
Q
A
L
K
V
L
R
TAEFA
P
F
V
V
F
I
AAPTITPGLN
E
D
E
S
L
Q
R
L
Q
K
E
S
D
I
L
Q
R
T
Y
A
H
Y
F
D
L
T
I
IN
N
E
I
D
E
T
I
R
H
L
E
E
A
V
E
L
VCTAPQ
W
V
PVSWVY
2
PsiBlast_PDB
95.44
100%
-127
- C2 -
3C0G
1
CSKP_HUMAN
A:
[20-336]
-----
V
L
F
E
D
V
Y
E
L
C
E
V
I
G
K
G
P
F
S
V
V
R
R
C
I
N
R
E
T
G
Q
Q
F
A
V
K
I
V
D
V
A
K
F
T
S
S
-
P
-
G
L
S
T
E
D
L
K
--
R
E
A
S
I
--
C
H
M
L
K
----
H
P
H
I
V
E
L
L
E
T
Y
S
S
D
G
M
L
Y
M
V
F
E
F
M
D
G
A
D
L
C
F
E
I
V
K
----------------------------------
R
A
D
A
G
F
V
Y
S
E
A
V
A
S
H
Y
M
R
Q
I
L
E
A
L
R
Y
C
H
D
N
N
I
I
H
R
D
V
K
P
H
C
V
L
L
A
S
K
E
-
N
S
A
P
-
V
K
L
G
G
F
G
V
A
I
Q
L
G
E
--
S
G
L
V
A
G
G
R
V
G
T
P
H
F
M
A
P
E
V
V
K
------
R
--
E
P
Y
G
K
P
V
D
V
W
G
C
G
V
I
L
F
I
L
L
S
G
C
L
P
F
Y
G
-
T
-
K
--
E
-
R
-
L
-
F
E
G
I
I
K
G
K
Y
K
M
N
P
R
Q
W
S
H
I
S
E
S
A
K
D
L
V
R
R
M
L
M
L
D
P
A
E
R
I
T
V
Y
E
A
L
N
H
P
W
L
K
E
R
D
------
R
Y
A
--
Y
K
I
H
L
P
E
T
V
--
E
-
Q
L
R
K
F
N
A
R
R
K
L
K
--
V
L
A
-
A
V
S
------
F
Y
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
93.83
100%
-128
- C2 -
3C0H
1
CSKP_HUMAN
B:
[19-318]
----
D
V
L
F
E
D
V
Y
E
L
C
E
V
I
G
K
G
P
F
S
V
V
R
R
C
I
N
R
E
T
G
Q
Q
F
A
V
K
I
V
D
V
A
K
F
T
S
S
-
P
-
G
L
S
T
E
D
L
K
--
R
E
A
S
I
--
C
H
M
L
K
----
H
P
H
I
V
E
L
L
E
T
Y
S
S
D
G
M
L
Y
M
V
F
E
F
M
D
G
A
D
L
C
F
E
I
V
K
----------------------------------
R
A
D
A
G
F
V
Y
S
E
A
V
A
S
H
Y
M
R
Q
I
L
E
A
L
R
Y
C
H
D
N
N
I
I
H
R
D
V
K
P
H
C
V
L
L
A
S
K
E
-
N
S
A
P
-
V
K
L
G
G
F
G
V
A
I
Q
L
G
E
--
S
G
L
V
A
G
G
R
V
G
T
P
H
F
M
A
P
E
V
V
K
------
R
--
E
P
Y
G
K
P
V
D
V
W
G
C
G
V
I
L
F
I
L
L
S
G
C
L
P
F
Y
G
-
T
-
K
--
E
-
R
-
L
-
F
E
G
I
I
K
G
K
Y
K
M
N
P
R
Q
W
S
H
I
S
E
S
A
K
D
L
V
R
R
M
L
M
L
D
P
A
E
R
I
T
V
Y
E
A
L
N
H
P
W
L
K
E
R
D
------
R
Y
A
--
Y
K
I
H
L
P
E
T
V
--
E
-
Q
L
R
K
F
N
A
R
R
K
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
93.75
100%
-122
- C2 -
3C0G
1
CSKP_HUMAN
B:
[19-338]
----
D
V
L
F
E
D
V
Y
E
L
C
E
V
I
G
K
G
P
F
S
V
V
R
R
C
I
N
R
E
T
G
Q
Q
F
A
V
K
I
V
D
V
A
K
F
T
S
S
-
P
-
G
L
S
T
E
D
L
K
--
R
E
A
S
I
--
C
H
M
L
K
----
H
P
H
I
V
E
L
L
E
T
Y
S
S
D
G
M
L
Y
M
V
F
E
F
M
D
G
A
D
L
C
F
E
I
V
K
----------------------------------
R
A
D
A
G
F
V
Y
S
E
A
V
A
S
H
Y
M
R
Q
I
L
E
A
L
R
Y
C
H
D
N
N
I
I
H
R
D
V
K
P
H
C
V
L
L
A
S
K
E
-
N
S
A
P
-
V
K
L
G
G
F
G
V
A
I
Q
L
G
E
--
S
G
L
V
A
G
G
R
V
G
T
P
H
F
M
A
P
E
V
V
K
------
R
--
E
P
Y
G
K
P
V
D
V
W
G
C
G
V
I
L
F
I
L
L
S
G
C
L
P
F
Y
G
-
T
-
K
--
E
-
R
-
L
-
F
E
G
I
I
K
G
K
Y
K
M
N
P
R
Q
W
S
H
I
S
E
S
A
K
D
L
V
R
R
M
L
M
L
D
P
A
E
R
I
T
V
Y
E
A
L
N
H
P
W
L
K
E
R
D
------
R
Y
A
--
Y
K
I
H
L
P
E
T
V
--
E
-
Q
L
R
K
F
N
A
R
R
K
L
K
G
A
V
L
A
-
A
V
S
S
H
K
F
N
S
F
Y
G
D
P
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
93.64
100%
-132
- C2 -
3C0H
1
CSKP_HUMAN
A:
[19-318]
----
D
V
L
F
E
D
V
Y
E
L
C
E
V
I
G
K
G
P
F
S
V
V
R
R
C
I
N
R
E
T
G
Q
Q
F
A
V
K
I
V
D
V
A
K
F
T
S
S
-
P
-
G
L
S
T
E
D
L
K
--
R
E
A
S
I
--
C
H
M
L
K
----
H
P
H
I
V
E
L
L
E
T
Y
S
S
D
G
M
L
Y
M
V
F
E
F
M
D
G
A
D
L
C
F
E
I
V
K
----------------------------------
R
A
D
A
G
F
V
Y
S
E
A
V
A
S
H
Y
M
R
Q
I
L
E
A
L
R
Y
C
H
D
N
N
I
I
H
R
D
V
K
P
H
C
V
L
L
A
S
K
E
-
N
S
A
P
-
V
K
L
G
G
F
G
V
A
I
Q
L
G
E
--
S
G
L
V
A
G
G
R
V
G
T
P
H
F
M
A
P
E
V
V
K
------
R
--
E
P
Y
G
K
P
V
D
V
W
G
C
G
V
I
L
F
I
L
L
S
G
C
L
P
F
Y
G
-
T
-
K
--
E
-
R
-
L
-
F
E
G
I
I
K
G
K
Y
K
M
N
P
R
Q
W
S
H
I
S
E
S
A
K
D
L
V
R
R
M
L
M
L
D
P
A
E
R
I
T
V
Y
E
A
L
N
H
P
W
L
K
E
R
D
------
R
Y
A
--
Y
K
I
H
L
P
E
T
V
--
E
-
Q
L
R
K
F
N
A
R
R
K
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
92.53
98%
-125
- C2 -
3MFR
1
CSKP_HUMAN
A:
[19-320]
----
D
V
L
F
E
D
V
Y
E
L
C
E
V
I
G
K
G
A
F
S
V
V
R
R
C
I
N
R
E
T
G
Q
Q
F
A
V
K
I
V
D
V
A
K
F
T
S
S
-
P
-
G
L
S
T
E
D
L
K
--
R
E
A
S
I
--
C
H
M
L
K
----
H
P
H
I
V
E
L
L
E
T
Y
S
S
D
G
M
L
Y
M
V
F
E
F
M
D
G
A
D
L
C
F
E
I
V
K
----------------------------------
R
A
D
A
G
F
V
Y
S
E
A
V
A
S
H
Y
M
R
Q
I
L
E
A
L
R
Y
C
H
D
N
N
I
I
H
R
D
V
K
P
E
N
V
L
L
A
S
K
E
-
N
S
A
P
-
V
K
L
G
D
F
G
V
A
I
Q
L
G
E
--
S
G
L
V
A
G
G
R
V
G
T
P
H
F
M
A
P
E
V
V
K
------
R
--
E
P
Y
G
K
P
V
D
V
W
G
C
G
V
I
L
F
I
L
L
S
G
C
L
P
F
Y
G
-
T
-
K
--
E
-
R
-
L
-
F
E
G
I
I
K
G
K
Y
K
M
N
P
R
Q
W
S
H
I
S
E
S
A
K
D
L
V
R
R
M
L
M
L
D
P
A
E
R
I
T
V
Y
E
A
L
N
H
P
W
L
K
E
R
D
------
R
Y
A
--
Y
K
I
H
L
P
E
T
V
--
E
-
Q
L
R
K
F
N
A
R
R
K
L
K
G
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
92.38
98%
-125
- C2 -
3MFU
1
CSKP_HUMAN
A:
[19-320]
----
D
V
L
F
E
D
V
Y
E
L
C
E
V
I
G
K
G
A
F
S
V
V
R
R
C
I
N
R
E
T
G
Q
Q
F
A
V
K
I
V
D
V
A
K
F
T
S
S
-
P
-
G
L
S
T
E
D
L
K
--
R
E
A
S
I
--
C
H
M
L
K
----
H
P
H
I
V
E
L
L
E
T
Y
S
S
D
G
M
L
Y
M
V
F
E
F
M
D
G
A
D
L
C
F
E
I
V
K
----------------------------------
R
A
D
A
G
F
V
Y
S
E
A
V
A
S
H
Y
M
R
Q
I
L
E
A
L
R
Y
C
H
D
N
N
I
I
H
R
D
V
K
P
E
N
V
L
L
A
S
K
E
-
N
S
A
P
-
V
K
L
G
D
F
G
V
A
I
Q
L
G
E
--
S
G
L
V
A
G
G
R
V
G
T
P
H
F
M
A
P
E
V
V
K
------
R
--
E
P
Y
G
K
P
V
D
V
W
G
C
G
V
I
L
F
I
L
L
S
G
C
L
P
F
Y
G
-
T
-
K
--
E
-
R
-
L
-
F
E
G
I
I
K
G
K
Y
K
M
N
P
R
Q
W
S
H
I
S
E
S
A
K
D
L
V
R
R
M
L
M
L
D
P
A
E
R
I
T
V
Y
E
A
L
N
H
P
W
L
K
E
R
D
------
R
Y
A
--
Y
K
I
H
L
P
E
T
V
--
E
-
Q
L
R
K
F
N
A
R
R
K
L
K
G
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
92.04
98%
-127
- C2 -
3MFS
1
CSKP_HUMAN
A:
[18-320]
---
D
D
V
L
F
E
D
V
Y
E
L
C
E
V
I
G
K
G
A
F
S
V
V
R
R
C
I
N
R
E
T
G
Q
Q
F
A
V
K
I
V
D
V
A
K
F
T
S
S
-
P
-
G
L
S
T
E
D
L
K
--
R
E
A
S
I
--
C
H
M
L
K
----
H
P
H
I
V
E
L
L
E
T
Y
S
S
D
G
M
L
Y
M
V
F
E
F
M
D
G
A
D
L
C
F
E
I
V
K
----------------------------------
R
A
D
A
G
F
V
Y
S
E
A
V
A
S
H
Y
M
R
Q
I
L
E
A
L
R
Y
C
H
D
N
N
I
I
H
R
D
V
K
P
E
N
V
L
L
A
S
K
E
-
N
S
A
P
-
V
K
L
G
D
F
G
V
A
I
Q
L
G
E
--
S
G
L
V
A
G
G
R
V
G
T
P
H
F
M
A
P
E
V
V
K
------
R
--
E
P
Y
G
K
P
V
D
V
W
G
C
G
V
I
L
F
I
L
L
S
G
C
L
P
F
Y
G
-
T
-
K
--
E
-
R
-
L
-
F
E
G
I
I
K
G
K
Y
K
M
N
P
R
Q
W
S
H
I
S
E
S
A
K
D
L
V
R
R
M
L
M
L
D
P
A
E
R
I
T
V
Y
E
A
L
N
H
P
W
L
K
E
R
D
------
R
Y
A
--
Y
K
I
H
L
P
E
T
V
--
E
-
Q
L
R
K
F
N
A
R
R
K
L
K
G
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
125
HHSearch
91.77
100%
-127
- C2 -
3C0I
1
CSKP_HUMAN
A:
[20-317]
-----
V
L
F
E
D
V
Y
E
L
C
E
V
I
G
K
G
P
F
S
V
V
R
R
C
I
N
R
E
T
G
Q
Q
F
A
V
K
I
V
D
V
A
K
F
T
S
S
-
P
-
G
L
S
T
E
D
L
K
--
R
E
A
S
I
--
C
H
M
L
K
----
H
P
H
I
V
E
L
L
E
T
Y
S
S
D
G
M
L
Y
M
V
F
E
F
M
D
G
A
D
L
C
F
E
I
V
K
----------------------------------
R
A
D
A
G
F
V
Y
S
E
A
V
A
S
H
Y
M
R
Q
I
L
E
A
L
R
Y
C
H
D
N
N
I
I
H
R
D
V
K
P
H
C
V
L
L
A
S
K
E
-
N
S
A
P
-
V
K
L
G
G
F
G
V
A
I
Q
L
G
E
--
S
G
L
V
A
G
G
R
V
G
T
P
H
F
M
A
P
E
V
V
K
------
R
--
E
P
Y
G
K
P
V
D
V
W
G
C
G
V
I
L
F
I
L
L
S
G
C
L
P
F
Y
G
-
T
-
K
--
E
-
R
-
L
-
F
E
G
I
I
K
G
K
Y
K
M
N
P
R
Q
W
S
H
I
S
E
S
A
K
D
L
V
R
R
M
L
M
L
D
P
A
E
R
I
T
V
Y
E
A
L
N
H
P
W
L
K
E
R
D
------
R
Y
A
--
Y
K
I
H
L
P
E
T
V
--
E
-
Q
L
R
K
F
N
A
R
R
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
91.77
100%
-127
- C2 -
3C0I
1
CSKP_HUMAN
A:
[20-317]
-----
V
L
F
E
D
V
Y
E
L
C
E
V
I
G
K
G
P
F
S
V
V
R
R
C
I
N
R
E
T
G
Q
Q
F
A
V
K
I
V
D
V
A
K
F
T
S
S
-
P
-
G
L
S
T
E
D
L
K
--
R
E
A
S
I
--
C
H
M
L
K
----
H
P
H
I
V
E
L
L
E
T
Y
S
S
D
G
M
L
Y
M
V
F
E
F
M
D
G
A
D
L
C
F
E
I
V
K
----------------------------------
R
A
D
A
G
F
V
Y
S
E
A
V
A
S
H
Y
M
R
Q
I
L
E
A
L
R
Y
C
H
D
N
N
I
I
H
R
D
V
K
P
H
C
V
L
L
A
S
K
E
-
N
S
A
P
-
V
K
L
G
G
F
G
V
A
I
Q
L
G
E
--
S
G
L
V
A
G
G
R
V
G
T
P
H
F
M
A
P
E
V
V
K
------
R
--
E
P
Y
G
K
P
V
D
V
W
G
C
G
V
I
L
F
I
L
L
S
G
C
L
P
F
Y
G
-
T
-
K
--
E
-
R
-
L
-
F
E
G
I
I
K
G
K
Y
K
M
N
P
R
Q
W
S
H
I
S
E
S
A
K
D
L
V
R
R
M
L
M
L
D
P
A
E
R
I
T
V
Y
E
A
L
N
H
P
W
L
K
E
R
D
------
R
Y
A
--
Y
K
I
H
L
P
E
T
V
--
E
-
Q
L
R
K
F
N
A
R
R
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
76.22
46%
-112
- C2 -
2V7O
3
KCC2G_HUMAN
A:
[29-321]
-------
F
T
D
D
Y
Q
L
F
E
E
L
G
K
G
-
F
S
V
V
R
R
C
V
K
K
T
P
T
Q
E
Y
A
A
K
I
I
N
T
K
K
L
S
A
R
-----
D
H
Q
K
L
E
--
R
E
A
R
I
--
C
R
L
L
K
----
H
P
N
I
V
R
L
H
D
S
I
S
E
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
----------------------------------
R
E
----
Y
Y
S
E
A
D
A
S
H
C
I
H
Q
I
L
E
S
V
N
H
I
H
Q
H
D
I
V
H
R
D
L
K
P
E
N
L
L
L
A
S
K
C
-
K
G
A
A
-
V
K
L
A
D
F
G
L
A
I
E
V
Q
G
--
E
Q
Q
A
W
F
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
R
------
K
--
D
P
Y
G
K
P
V
D
I
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
D
-
E
-
D
--
Q
H
K
-
L
-
Y
Q
Q
I
K
A
G
A
Y
D
F
P
S
P
E
W
D
T
V
T
P
E
A
K
N
L
I
N
Q
M
L
T
I
N
P
A
K
R
I
T
A
D
Q
A
L
K
H
P
W
V
C
Q
R
S
------
T
V
A
--
S
M
M
H
R
Q
E
T
V
--
E
-
C
L
R
K
F
N
A
R
R
K
L
K
G
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
76.16
47%
-115
- C2 -
3BHH
1
KCC2B_HUMAN
A:
[4-293]
---------
D
E
Y
Q
L
Y
E
D
I
G
----
S
V
V
R
R
C
V
K
L
C
T
G
H
E
Y
A
A
K
I
I
N
T
K
K
L
S
A
R
-----
D
H
Q
K
L
E
--
R
E
A
R
I
--
C
R
L
L
K
----
H
S
N
I
V
R
L
H
D
S
I
S
E
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
----------------------------------
R
E
----
Y
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
A
V
L
H
C
H
Q
M
G
V
V
H
R
D
L
K
P
E
N
L
L
L
A
S
K
C
-
K
G
A
A
-
V
K
L
A
D
F
G
L
A
I
E
V
Q
G
--
D
Q
Q
A
W
F
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
R
------
K
--
E
A
Y
G
K
P
V
D
I
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
D
-
E
D
Q
--
H
-
K
-
L
-
Y
Q
Q
I
K
A
G
A
Y
D
F
P
S
P
E
W
D
T
V
T
P
E
A
K
N
L
I
N
Q
M
L
T
I
N
P
A
K
R
I
T
A
H
E
A
L
K
H
P
W
V
C
Q
R
S
------
T
V
A
--
S
M
M
H
R
Q
E
T
V
--
E
-
C
L
K
K
F
N
A
R
R
K
L
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
PsiBlast_CBE
76.02
47%
-116
- C2 -
3BHH
1
KCC2B_HUMAN
B:
[4-293]
---------
D
E
Y
Q
L
Y
E
D
I
G
K
---
S
V
V
R
R
C
V
K
L
C
T
G
H
E
Y
A
A
K
I
I
N
T
K
K
L
S
A
R
-----
D
H
Q
K
L
E
--
R
E
A
R
I
--
C
R
L
L
K
----
H
S
N
I
V
R
L
H
D
S
I
S
E
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
----------------------------------
R
E
----
Y
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
A
V
L
H
C
H
Q
M
G
V
V
H
R
D
L
K
P
E
N
L
L
L
A
S
K
C
-
K
G
A
A
-
V
K
L
A
D
F
G
L
A
I
E
V
Q
G
--
D
Q
Q
A
W
F
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
R
------
K
--
E
A
Y
G
K
P
V
D
I
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
D
-
E
D
Q
--
H
-
K
-
L
-
Y
Q
Q
I
K
A
G
A
Y
D
F
P
S
P
E
W
D
T
V
T
P
E
A
K
N
L
I
N
Q
M
L
T
I
N
P
A
K
R
I
T
A
H
E
A
L
K
H
P
W
V
C
Q
R
S
------
T
V
A
--
S
M
M
H
R
Q
E
T
V
--
E
-
C
L
K
K
F
N
A
R
R
K
L
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
74.55
47%
-114
- C2 -
2VN9
2
KCC2D_HUMAN
A:
[4-300]
---------
D
E
Y
Q
L
F
E
E
L
G
K
G
A
F
S
V
V
R
R
C
M
K
I
P
T
G
Q
E
Y
A
A
K
I
I
N
T
K
K
L
S
A
R
-----
D
H
Q
K
L
E
--
R
E
A
R
I
--
C
R
L
L
K
----
H
P
N
I
V
R
L
H
D
S
I
S
E
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
----------------------------------
R
E
----
Y
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
L
N
G
I
V
H
R
D
L
K
P
E
N
L
L
L
A
S
K
S
-
K
G
A
A
-
V
K
L
A
D
F
G
L
A
I
E
V
Q
G
--
D
Q
Q
A
W
F
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
R
------
K
--
D
P
Y
G
K
P
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
D
-
E
-
D
--
Q
H
R
-
L
-
Y
Q
Q
I
K
A
G
A
Y
D
F
P
S
P
E
W
D
T
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
A
K
R
I
T
A
S
E
A
L
K
H
P
W
I
C
Q
R
S
------
T
V
A
--
S
M
M
H
R
Q
E
T
V
--
D
-
C
L
K
K
F
N
A
R
R
K
L
K
G
A
I
L
T
-
T
M
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
PsiBlast_CBE
74.12
47%
-113
- C2 -
2VN9
1
KCC2D_HUMAN
B:
[4-300]
---------
D
E
Y
Q
L
F
E
E
L
G
K
G
A
F
S
V
V
R
R
C
M
K
I
P
T
G
Q
E
Y
A
A
K
I
I
N
T
K
K
L
S
A
R
-----
D
H
Q
K
L
E
--
R
E
A
R
I
--
C
R
L
L
K
----
H
P
N
I
V
R
L
H
D
S
I
S
E
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
----------------------------------
R
E
----
Y
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
L
N
G
I
V
H
R
D
L
K
P
E
N
L
L
L
A
S
K
S
-
K
G
A
A
-
V
K
L
A
D
F
G
L
A
I
E
V
Q
G
--
D
Q
Q
A
W
F
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
R
------
K
--
D
P
Y
G
K
P
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
D
-
E
-
D
--
Q
H
R
-
L
-
Y
Q
Q
I
K
A
G
A
Y
D
F
P
S
P
E
W
D
T
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
A
K
R
I
T
A
S
E
A
L
K
H
P
W
I
C
Q
R
S
------
T
V
A
--
S
M
M
H
R
Q
E
T
V
--
D
-
C
L
K
K
F
N
A
R
R
K
L
K
G
A
I
L
T
-
T
M
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
72.88
47%
-121
- C2 -
2WEL
7
KCC2D_HUMAN
A:
[4-300]
---------
D
E
Y
Q
L
F
E
E
L
G
K
G
A
F
S
V
V
R
R
C
M
K
I
P
T
G
Q
E
Y
A
A
K
I
I
N
T
K
K
L
S
A
R
-----
D
H
Q
K
L
E
--
R
E
A
R
I
--
C
R
L
L
K
----
H
P
N
I
V
R
L
H
D
S
I
S
E
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
----------------------------------
R
E
----
Y
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
L
N
G
I
V
H
R
D
L
K
P
E
N
L
L
L
A
S
K
S
-
K
G
A
A
-
V
K
L
A
D
F
G
L
A
I
E
V
Q
G
--
D
Q
Q
A
W
F
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
R
------
K
--
D
P
Y
G
K
P
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
D
-
E
-
D
--
Q
H
R
-
L
-
Y
Q
Q
I
K
A
G
A
Y
D
F
P
S
P
E
W
D
T
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
A
K
R
I
T
A
S
E
A
L
K
H
P
W
I
C
Q
R
------------
S
M
M
H
R
Q
E
T
V
--
D
-
C
L
K
K
F
N
A
R
R
K
L
K
G
A
I
L
T
-
T
M
L
A
T
R
N
F
S
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
140
HHSearch
70.43
36%
-115
- C2 -
2W4O
1
KCC4_HUMAN
A:
[50-346]
------
A
L
S
D
F
F
E
V
E
S
E
L
G
R
G
A
T
S
I
V
Y
R
C
K
Q
K
G
T
Q
K
P
Y
A
L
K
V
L
K
K
---------------------
I
G
V
--
L
L
R
L
S
----
H
P
N
I
I
K
L
K
E
I
F
E
T
P
T
E
I
S
L
V
L
E
L
V
T
G
G
E
L
F
D
R
I
V
E
----------------------------------
K
---
G
-
Y
Y
S
E
R
D
A
A
D
A
V
K
Q
I
L
E
A
V
A
Y
L
H
E
N
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
A
T
P
A
-
P
D
A
P
-
L
K
I
A
D
F
-------------------
G
T
P
G
Y
C
A
P
E
I
L
R
------
G
--
C
A
Y
G
P
E
V
D
M
W
S
V
G
I
I
T
Y
I
L
L
C
G
F
E
P
F
Y
D
-
E
-
R
G
D
Q
-
F
-
M
-
F
R
R
I
L
N
C
E
Y
Y
F
I
S
P
W
W
D
E
V
S
L
N
A
K
D
L
V
R
K
L
I
V
L
D
P
K
K
R
L
T
T
F
Q
A
L
Q
H
P
W
V
T
G
K
A
--------
A
--
N
F
V
H
M
D
T
A
Q
--
K
-
K
L
Q
E
F
N
A
R
R
K
L
K
A
A
V
K
A
-
V
V
A
S
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
136
HHSearch
69.40
33%
-115
- C2 -
3HKO
2
?
A:
[23-344]
------
E
L
Q
K
K
Y
H
L
K
G
A
I
G
Q
G
S
Y
G
V
V
R
V
A
I
E
N
Q
T
R
A
I
R
A
I
K
I
M
N
K
N
K
I
R
Q
-----
K
D
V
E
R
I
K
--
T
E
V
R
L
--
M
K
K
L
H
----
H
P
N
I
A
R
L
Y
E
V
Y
E
D
E
Q
Y
I
C
L
V
M
E
L
C
H
G
G
H
L
L
D
K
L
N
V
F
I
DDSTG
K
C
A
M
D
V
V
KTQICPC
P
E
C
N
E
E
A
I
N
G
SIF
R
E
S
L
D
F
V
Q
R
E
K
L
I
S
N
I
M
R
Q
I
F
S
A
L
H
Y
L
H
N
Q
G
I
C
H
R
D
I
K
P
E
N
F
L
F
S
T
N
--
K
S
F
E
-
I
K
L
V
D
F
G
L
S
K
E
F
Y
K
LN
N
G
------
A
G
T
P
Y
F
V
A
P
E
V
L
N
------
T
TN
E
S
Y
G
P
K
C
D
A
W
S
A
G
V
L
L
H
L
L
L
M
G
A
V
P
F
P
G
-
V
N
D
--
A
-
D
-
T
-
I
S
Q
V
L
N
K
K
L
C
F
E
N
P
N
Y
N
V
L
S
P
L
A
R
D
L
L
S
N
L
L
N
R
N
V
D
E
R
F
D
A
M
R
A
L
Q
H
P
W
I
S
Q
F
S
------
D
K
I
--
Y
K
M
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
89
PsiBlast_CBE
69.25
34%
-114
- C2 -
2CKE
1
DAPK2_HUMAN
A:
[11-302]
--------
E
D
F
Y
D
I
G
E
E
L
G
S
G
Q
F
A
I
V
K
K
C
R
E
K
S
T
G
L
E
Y
A
A
K
F
I
K
K
R
Q
S
R
A
S
-
R
R
G
V
S
R
E
E
I
E
--
R
E
V
S
I
--
L
R
Q
V
L
----
H
H
N
V
I
T
L
H
D
V
Y
E
N
R
T
D
V
V
L
I
L
E
L
V
S
G
G
E
L
-
F
D
F
L
A
----------------------------------
Q
K
E
S
---
L
S
E
E
E
A
T
S
F
I
K
Q
I
L
D
G
V
N
Y
L
H
T
K
K
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
K
N
-
I
P
I
P
H
I
K
L
I
D
F
G
L
A
H
E
I
-
E
--
D
G
V
E
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
------
Y
--
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
-
K
--
Q
-
E
-
T
-
L
A
N
I
T
S
V
S
Y
D
F
D
E
E
F
F
S
H
T
S
E
L
A
K
D
F
I
R
K
L
L
V
K
E
T
R
K
R
L
T
I
Q
E
A
L
R
H
P
W
I
T
P
V
D
------
N
Q
Q
--
A
M
V
R
R
E
S
V
V
N
L
E
-
N
F
R
K
Q
Y
V
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
88
PsiBlast_CBE
69.21
34%
-118
- C2 -
2CKE
1
DAPK2_HUMAN
B:
[11-302]
--------
E
D
F
Y
D
I
G
E
E
L
G
S
G
Q
F
A
I
V
K
K
C
R
E
K
S
T
G
L
E
Y
A
A
K
F
I
K
K
R
Q
S
R
A
S
-
R
R
G
V
S
R
E
E
I
E
--
R
E
V
S
I
--
L
R
Q
V
L
----
H
H
N
V
I
T
L
H
D
V
Y
E
N
R
T
D
V
V
L
I
L
E
L
V
S
G
G
E
L
-
F
D
F
L
A
----------------------------------
Q
K
E
S
---
L
S
E
E
E
A
T
S
F
I
K
Q
I
L
D
G
V
N
Y
L
H
T
K
K
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
K
N
-
I
P
I
P
H
I
K
L
I
D
F
G
L
A
H
E
I
-
E
--
D
G
V
E
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
------
Y
--
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
-
K
--
Q
-
E
-
T
-
L
A
N
I
T
S
V
S
Y
D
F
D
E
E
F
F
S
H
T
S
E
L
A
K
D
F
I
R
K
L
L
V
K
E
T
R
K
R
L
T
I
Q
E
A
L
R
H
P
W
I
T
P
V
D
------
N
Q
Q
--
A
M
V
R
R
E
S
V
V
N
L
E
-
N
F
R
K
Q
Y
V
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
79
PsiBlast_CBE
68.84
37%
-128
- C2 -
2Y7J
1
PHKG2_HUMAN
D:
[92-364]
-------
F
Y
Q
K
Y
D
P
K
D
V
I
G
R
G
V
S
S
V
V
R
R
C
V
H
R
A
T
G
H
E
F
A
V
K
I
M
E
V
---------
R
L
S
P
E
Q
L
E
EV
R
E
A
T
R
RE
T
H
I
L
R
QVAG
H
P
H
I
I
T
L
I
D
S
Y
E
S
S
S
F
M
F
L
V
F
D
L
M
R
K
G
E
L
F
D
Y
L
T
E
----------------------------------
K
V
----
A
L
S
E
K
E
T
R
S
I
M
R
S
L
L
E
A
V
S
F
L
H
A
N
N
I
V
H
R
D
L
K
P
E
N
I
L
L
---
D
-
D
N
M
Q
-
I
R
L
S
D
F
G
F
S
C
H
L
-
E
--
P
G
E
K
L
R
E
L
C
G
T
P
G
Y
L
A
P
E
I
L
K
CSMDET
H
--
P
G
Y
G
K
E
V
D
L
W
A
C
G
V
I
L
F
T
L
L
A
G
S
P
P
F
W
H
-
R
-
R
--
Q
-
I
-
L
M
L
R
M
I
M
E
G
Q
Y
Q
F
S
S
P
E
W
D
D
R
S
S
T
V
K
D
L
I
S
R
L
L
Q
V
D
P
E
A
R
L
T
A
E
Q
A
L
Q
H
P
F
F
E
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
69
PsiBlast_CBE
68.69
36%
-120
- C2 -
4FG8
1
KCC1A_HUMAN
B:
[18-299]
---------
D
I
Y
D
F
R
D
V
L
G
T
G
A
F
S
E
V
I
L
A
E
D
K
R
T
Q
K
L
V
A
I
K
C
I
A
K
-------------------
N
E
I
A
V
--
L
H
K
I
K
----
H
P
N
I
V
A
L
D
D
I
Y
E
S
G
G
H
L
Y
L
I
M
Q
L
V
S
G
G
E
L
F
D
R
I
V
E
----------------------------------
K
---
G
F
-
Y
T
E
R
D
A
S
R
L
I
F
Q
V
L
D
A
V
K
Y
L
H
D
L
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
Y
S
L
D
-
E
D
S
K
-
I
M
I
S
D
F
G
----------
G
S
V
L
S
T
A
C
G
T
P
G
Y
V
A
P
E
V
L
A
------
Q
--
K
P
Y
S
K
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
Y
D
-
E
-
N
--
D
A
K
-
L
-
F
E
Q
I
L
K
A
E
Y
E
F
D
S
P
Y
W
D
D
I
S
D
S
A
K
D
F
I
R
H
L
M
E
K
D
P
E
K
R
F
T
C
E
Q
A
L
Q
H
P
W
I
A
G
D
T
------
A
L
D
--
K
N
I
H
-
Q
S
V
S
--
E
-
Q
I
K
K
N
F
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
86
PsiBlast_CBE
68.60
34%
-111
- C2 -
2CKE
1
DAPK2_HUMAN
D:
[11-302]
--------
E
D
F
Y
D
I
G
E
E
L
G
S
G
Q
F
A
I
V
K
K
C
R
E
K
S
T
G
L
E
Y
A
A
K
F
I
K
K
R
Q
S
R
A
S
-
R
R
G
V
S
R
E
E
I
E
--
R
E
V
S
I
--
L
R
Q
V
L
----
H
H
N
V
I
T
L
H
D
V
Y
E
N
R
T
D
V
V
L
I
L
E
L
V
S
G
G
E
L
-
F
D
F
L
A
----------------------------------
Q
K
E
S
---
L
S
E
E
E
A
T
S
F
I
K
Q
I
L
D
G
V
N
Y
L
H
T
K
K
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
K
N
-
I
P
I
P
H
I
K
L
I
D
F
G
L
A
H
E
I
-
E
--
D
G
V
E
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
------
Y
--
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
-
K
--
Q
-
E
-
T
-
L
A
N
I
T
S
V
S
Y
D
F
D
E
E
F
F
S
H
T
S
E
L
A
K
D
F
I
R
K
L
L
V
K
E
T
R
K
R
L
T
I
Q
E
A
L
R
H
P
W
I
T
P
V
D
------
N
Q
Q
--
A
M
V
R
R
E
S
V
V
NL
E
-
N
F
R
K
Q
Y
V
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
77
PsiBlast_CBE
68.57
36%
-131
- C2 -
4FG7
1
KCC1A_HUMAN
A:
[18-276]
---------
D
I
Y
D
F
R
D
V
L
G
T
G
A
F
S
E
V
I
L
A
E
D
K
R
T
Q
K
L
V
A
I
K
C
I
A
---------------
S
M
E
--
N
E
I
A
V
--
L
H
K
I
K
----
H
P
N
I
V
A
L
D
D
I
Y
E
S
G
G
H
L
Y
L
I
M
Q
L
V
S
G
G
E
L
F
D
R
I
V
E
----------------------------------
K
---
G
F
-
Y
T
E
R
D
A
S
R
L
I
F
Q
V
L
D
A
V
K
Y
L
H
D
L
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
Y
S
L
D
-
E
D
S
K
-
I
M
I
S
D
F
G
L
S
-
K
M
E
D
--
P
G
--------
T
P
G
Y
V
A
P
E
V
L
A
------
Q
--
K
--
S
K
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
Y
D
-
E
-
N
--
D
A
K
-
L
-
F
E
Q
I
L
K
A
E
Y
E
F
D
S
P
Y
W
D
D
I
S
D
S
A
K
D
F
I
R
H
L
M
E
K
D
P
E
K
R
F
T
C
E
Q
A
L
Q
H
P
W
I
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
110
PsiBlast_CBE
68.56
34%
-112
- C2 -
2YAA
1
DAPK2_MOUSE
B:
[11-302]
--------
E
D
F
Y
D
I
G
E
E
L
G
S
G
Q
F
A
I
V
K
K
C
R
E
K
S
T
G
L
E
Y
A
A
K
F
I
K
K
R
Q
S
R
A
S
-
R
R
G
V
C
R
E
E
I
E
--
R
E
V
S
I
--
L
R
Q
V
L
----
H
P
N
I
I
T
L
H
D
V
Y
E
N
R
T
D
V
V
L
I
L
E
L
V
S
G
G
E
L
-
F
D
F
L
A
----------------------------------
Q
K
E
S
---
L
S
E
E
E
A
T
S
F
I
K
Q
I
L
D
G
V
N
Y
L
H
T
K
K
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
K
N
-
I
P
I
P
H
I
K
L
I
D
F
G
L
A
H
E
I
-
E
--
D
G
V
E
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
------
Y
--
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
-
K
--
Q
-
E
-
T
-
L
A
N
I
T
A
V
S
Y
D
F
D
E
E
F
F
S
Q
T
S
E
L
A
K
D
F
I
R
K
L
L
V
K
E
T
R
K
R
L
T
I
Q
E
A
L
R
H
P
W
I
T
P
V
D
------
T
Q
Q
--
A
M
V
R
R
E
S
V
V
N
L
E
-
N
F
K
K
Q
Y
V
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
111
PsiBlast_CBE
68.21
34%
-113
- C2 -
2YAA
1
DAPK2_MOUSE
A:
[11-302]
--------
E
D
F
Y
D
I
G
E
E
L
G
S
G
Q
F
A
I
V
K
K
C
R
E
K
S
T
G
L
E
Y
A
A
K
F
I
K
K
R
Q
S
R
A
S
-
R
R
G
V
C
R
E
E
I
E
--
R
E
V
S
I
--
L
R
Q
V
L
----
H
P
N
I
I
T
L
H
D
V
Y
E
N
R
T
D
V
V
L
I
L
E
L
V
S
G
G
E
L
-
F
D
F
L
A
----------------------------------
Q
K
E
S
---
L
S
E
E
E
A
T
S
F
I
K
Q
I
L
D
G
V
N
Y
L
H
T
K
K
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
K
N
-
I
P
I
P
H
I
K
L
I
D
F
G
L
A
H
E
I
-
E
--
D
G
V
E
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
------
Y
--
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
-
K
--
Q
-
E
-
T
-
L
A
N
I
T
A
V
S
Y
D
F
D
E
E
F
F
S
Q
T
S
E
L
A
K
D
F
I
R
K
L
L
V
K
E
T
R
K
R
L
T
I
Q
E
A
L
R
H
P
W
I
T
P
V
D
------
T
Q
Q
--
A
M
V
R
R
E
S
V
V
N
L
E
-
N
F
K
K
Q
Y
V
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
81
PsiBlast_CBE
68.20
37%
-128
- C2 -
2Y7J
1
PHKG2_HUMAN
A:
[92-364]
-------
F
Y
Q
K
Y
D
P
K
D
V
I
G
R
G
V
S
S
V
V
R
R
C
V
H
R
A
T
G
H
E
F
A
V
K
I
M
E
V
----
T
A
-
E
-
R
L
S
P
E
Q
L
E
E
V
R
E
A
T
R
R
E
T
H
I
L
R
Q
V
AG
H
P
H
I
I
T
L
I
D
S
Y
E
S
S
S
F
M
F
L
V
F
D
L
M
R
K
G
E
L
F
D
Y
L
T
E
----------------------------------
K
V
----
A
L
S
E
K
E
T
R
S
I
M
R
S
L
L
E
A
V
S
F
L
H
A
N
N
I
V
H
R
D
L
K
P
E
N
I
L
L
---
D
-
D
N
M
Q
-
I
R
L
S
D
F
G
F
S
C
H
L
-
E
--
P
G
E
K
L
R
E
L
C
G
T
P
G
Y
L
A
P
E
I
L
K
C
S
M
D
ET
H
--
P
G
Y
G
K
E
V
D
L
W
A
C
G
V
I
L
F
T
L
L
A
G
S
P
P
F
W
H
-
R
-
R
--
Q
-
I
-
L
M
L
R
M
I
M
E
G
Q
Y
Q
F
S
S
P
E
W
D
D
R
S
S
T
V
K
D
L
I
S
R
L
L
Q
V
D
P
E
A
R
L
T
A
E
Q
A
L
Q
H
P
F
F
E
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
84
PsiBlast_CBE
68.03
36%
-119
- C2 -
2JC6
1
KCC1D_HUMAN
C:
[23-314]
----------
I
F
E
F
K
E
T
L
G
T
G
A
F
S
E
V
V
L
A
E
E
K
A
T
G
K
L
F
A
V
K
C
I
P
K
K
A
------------
S
I
E
--
N
E
I
A
V
--
L
R
K
I
K
----
H
E
N
I
V
A
L
E
D
I
Y
E
S
P
N
H
L
Y
L
V
M
Q
L
V
S
G
G
E
L
F
D
R
I
V
E
----------------------------------
K
---
G
F
-
Y
T
E
K
D
A
S
T
L
I
R
Q
V
L
D
A
V
Y
Y
L
H
R
M
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
Y
S
Q
D
-
E
E
S
K
-
I
M
I
S
-----------------------
P
G
Y
V
A
P
E
V
L
A
------
Q
--
K
P
Y
S
K
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
Y
D
-
E
-
N
--
D
S
K
-
L
-
F
E
Q
I
L
K
A
E
Y
E
F
D
S
P
Y
W
D
D
I
S
D
S
A
K
D
F
I
R
N
L
M
E
K
D
P
N
K
R
Y
T
C
E
Q
A
A
R
H
P
W
I
A
G
D
T
------
A
L
N
--
K
N
I
H
--
E
S
V
--
S
A
Q
I
R
K
N
F
A
K
S
K
W
R
Q
A
F
N
A
T----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
70
PsiBlast_CBE
68.02
36%
-120
- C2 -
4FG8
1
KCC1A_HUMAN
A:
[18-299]
---------
D
I
Y
D
F
R
D
V
L
G
T
G
A
F
S
E
V
I
L
A
E
D
K
R
T
Q
K
L
V
A
I
K
C
I
A
K
E
------------------
N
E
I
A
V
--
L
H
K
I
K
----
H
P
N
I
V
A
L
D
D
I
Y
E
S
G
G
H
L
Y
L
I
M
Q
L
V
S
G
G
E
L
F
D
R
I
V
E
----------------------------------
K
---
G
F
-
Y
T
E
R
D
A
S
R
L
I
F
Q
V
L
D
A
V
K
Y
L
H
D
L
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
Y
S
L
D
-
E
D
S
K
-
I
M
I
S
D
F
--------------------
T
P
G
Y
V
A
P
E
V
L
A
------
Q
--
K
P
Y
S
K
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
Y
D
-
E
-
N
--
D
A
K
-
L
-
F
E
Q
I
L
K
A
E
Y
E
F
D
S
P
Y
W
D
D
I
S
D
S
A
K
D
F
I
R
H
L
M
E
K
D
P
E
K
R
F
T
C
E
Q
A
L
Q
H
P
W
I
A
G
D
T
------
A
L
D
--
K
N
I
H
-
Q
S
V
S
--
E
-
Q
I
K
K
N
F
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
87
PsiBlast_CBE
67.97
34%
-112
- C2 -
2CKE
1
DAPK2_HUMAN
C:
[11-302]
--------
E
D
F
Y
D
I
G
E
E
L
G
S
G
Q
F
A
I
V
K
K
C
R
E
K
S
T
G
L
E
Y
A
A
K
F
I
K
K
R
Q
S
R
A
S
-
R
R
G
V
S
R
E
E
I
E
--
R
E
V
S
I
--
L
R
Q
V
L
----
H
H
N
V
I
T
L
H
D
V
Y
E
N
R
T
D
V
V
L
I
L
E
L
V
S
G
G
E
L
-
F
D
F
L
A
----------------------------------
Q
K
E
S
---
L
S
E
E
E
A
T
S
F
I
K
Q
I
L
D
G
V
N
Y
L
H
T
K
K
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
K
N
-
I
P
I
P
H
I
K
L
I
D
F
G
L
A
H
E
I
-
E
--
D
G
V
E
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
------
Y
--
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
-
K
--
Q
-
E
-
T
-
L
A
N
I
T
S
V
S
Y
D
F
D
E
E
F
F
S
H
T
S
E
L
A
K
D
F
I
R
K
L
L
V
K
E
T
R
K
R
L
T
I
Q
E
A
L
R
H
P
W
I
T
P
V
D
------
N
Q
Q
--
A
M
V
R
R
E
S
V
V
NL
E
-
N
F
R
K
Q
Y
V
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
75
PsiBlast_CBE
67.79
36%
-104
- C2 -
2JAM
3
KCC1G_HUMAN
A:
[15-290]
---------------
E
V
L
G
S
G
A
F
S
E
V
F
L
V
K
Q
R
L
T
G
K
L
F
A
L
K
C
I
K
-----
K
--------
S
S
L
E
--
N
E
I
A
V
--
L
K
K
I
K
----
H
E
N
I
V
T
L
E
D
I
Y
E
S
T
T
H
Y
Y
L
V
M
Q
L
V
S
G
G
E
L
F
D
R
I
L
E
----------------------------------
R
G
----
V
Y
T
E
K
D
A
S
L
V
I
Q
Q
V
L
S
A
V
K
Y
L
H
E
N
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
L
T
P
E
-
E
N
S
K
-
I
M
I
T
D
F
G
L
S
-
K
M
E
Q
--
N
G
I
M
S
T
A
-
C
G
T
P
G
Y
V
A
P
E
V
L
A
------
Q
--
K
P
Y
S
K
A
V
D
C
W
S
I
G
V
I
T
Y
I
L
L
C
G
Y
P
P
F
Y
E
E
T
-
E
--
S
-
K
-
L
-
F
E
K
I
K
E
G
Y
Y
E
F
E
S
P
F
W
D
D
I
S
E
S
A
K
D
F
I
C
H
L
L
E
K
D
P
N
E
R
Y
T
C
E
K
A
L
S
H
P
W
I
D
G
N
T
------
A
L
H
--
R
D
I
Y
-
P
S
V
S
--
L
-
Q
I
Q
K
N
F
A
K
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
82
PsiBlast_CBE
67.71
34%
-112
- C2 -
2W4K
1
DAPK1_HUMAN
A:
[10-302]
--------
D
D
Y
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
R
T
K
S
S
-
R
R
G
V
S
R
E
D
I
E
--
R
E
V
S
I
--
L
K
E
I
Q
----
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
-
F
D
F
L
A
----------------------------------
E
K
E
S
---
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
-
V
P
K
P
R
I
K
I
I
D
F
G
L
A
H
K
I
-
D
--
F
G
N
E
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
------
Y
--
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
-
K
--
Q
-
E
-
T
-
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
P
K
D
T
Q
Q
A
L
S
R
K
A
--
S
A
V
N
M
------
E
-
K
F
K
K
F
A
A
R
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
80
PsiBlast_CBE
67.68
37%
-125
- C2 -
2Y7J
1
PHKG2_HUMAN
C:
[92-364]
-------
F
Y
Q
K
Y
D
P
K
D
V
I
G
R
G
V
S
S
V
V
R
R
C
V
H
R
A
T
G
H
E
F
A
V
K
I
M
E
V
----
T
A
-
E
-
R
L
S
P
E
Q
L
E
EV
R
E
A
T
R
RE
T
H
I
L
R
QVAG
H
P
H
I
I
T
L
I
D
S
Y
E
S
S
S
F
M
F
L
V
F
D
L
M
R
K
G
E
L
F
D
Y
L
T
E
----------------------------------
K
V
----
A
L
S
E
K
E
T
R
S
I
M
R
S
L
L
E
A
V
S
F
L
H
A
N
N
I
V
H
R
D
L
K
P
E
N
I
L
L
---
D
-
D
N
M
Q
-
I
R
L
S
D
F
G
F
S
C
H
L
-
E
--
P
G
E
K
L
R
E
L
C
G
T
P
G
Y
L
A
P
E
I
L
K
CSMDET
H
--
P
G
Y
G
K
E
V
D
L
W
A
C
G
V
I
L
F
T
L
L
A
G
S
P
P
F
W
H
-
R
-
R
--
Q
-
I
-
L
M
L
R
M
I
M
E
G
Q
Y
Q
F
S
S
P
E
W
D
D
R
S
S
T
V
K
D
L
I
S
R
L
L
Q
V
D
P
E
A
R
L
T
A
E
Q
A
L
Q
H
P
F
F
E
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
85
PsiBlast_CBE
67.66
36%
-117
- C2 -
2JC6
1
KCC1D_HUMAN
A:
[23-314]
----------
I
F
E
F
K
E
T
L
G
T
G
A
F
S
E
V
V
L
A
E
E
K
A
T
G
K
L
F
A
V
K
C
I
P
K
K
A
-------
S
----
S
I
E
--
N
E
I
A
V
--
L
R
K
I
K
----
H
E
N
I
V
A
L
E
D
I
Y
E
S
P
N
H
L
Y
L
V
M
Q
L
V
S
G
G
E
L
F
D
R
I
V
E
----------------------------------
K
---
G
F
-
Y
T
E
K
D
A
S
T
L
I
R
Q
V
L
D
A
V
Y
Y
L
H
R
M
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
Y
S
Q
D
-
E
E
S
K
-
I
M
I
S
-----------------------
P
G
Y
V
A
P
E
V
L
A
------
Q
--
K
P
Y
S
K
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
Y
D
-
E
-
N
--
D
S
K
-
L
-
F
E
Q
I
L
K
A
E
Y
E
F
D
S
P
Y
W
D
D
I
S
D
S
A
K
D
F
I
R
N
L
M
E
K
D
P
N
K
R
Y
T
C
E
Q
A
A
R
H
P
W
I
A
G
D
T
------
A
L
N
--
K
N
I
H
--
E
S
V
--
S
A
Q
I
R
K
N
F
A
K
S
K
W
R
Q
A
F
N
A
T----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
67
PsiBlast_CBE
67.61
36%
-110
- C2 -
4FG9
1
KCC1A_HUMAN
B:
[18-314]
---------
D
I
Y
D
F
R
D
V
L
G
T
G
A
F
S
E
V
I
L
A
E
D
K
R
T
Q
K
L
V
A
I
K
C
I
A
K
--------------------
E
I
A
V
--
L
H
K
I
K
----
H
P
N
I
V
A
L
D
D
I
Y
E
S
G
G
H
L
Y
L
I
M
Q
L
V
S
G
G
E
L
F
D
R
I
V
E
----------------------------------
K
---
G
F
-
Y
T
E
R
D
A
S
R
L
I
F
Q
V
L
D
A
V
K
Y
L
H
D
L
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
Y
S
L
D
-
E
D
S
K
-
I
M
I
S
D
F
-------------
V
L
S
T
A
C
G
T
P
G
Y
V
A
P
E
V
L
A
------
Q
--
K
P
Y
S
K
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
Y
D
-
E
-
N
--
D
A
K
-
L
-
F
E
Q
I
L
K
A
E
Y
E
F
D
S
P
Y
W
D
D
I
S
D
S
A
K
D
F
I
R
H
L
M
E
K
D
P
E
K
R
F
T
C
E
Q
A
L
Q
H
P
W
I
A
G
D
T
------
A
L
D
--
K
N
I
H
-
Q
S
V
S
--
E
-
Q
I
K
K
N
F
A
K
S
K
W
K
Q
A
F
N
A
T
A
V
V
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
68
PsiBlast_CBE
67.55
36%
-112
- C2 -
4FG9
1
KCC1A_HUMAN
A:
[18-314]
---------
D
I
Y
D
F
R
D
V
L
G
T
G
A
F
S
E
V
I
L
A
E
D
K
R
T
Q
K
L
V
A
I
K
C
I
A
K
E
---------------
E
--
N
E
I
A
V
--
L
H
K
I
K
----
H
P
N
I
V
A
L
D
D
I
Y
E
S
G
G
H
L
Y
L
I
M
Q
L
V
S
G
G
E
L
F
D
R
I
V
E
----------------------------------
K
---
G
F
-
Y
T
E
R
D
A
S
R
L
I
F
Q
V
L
D
A
V
K
Y
L
H
D
L
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
Y
S
L
D
-
E
D
S
K
-
I
M
I
S
D
F
---------------------
P
G
Y
V
A
P
E
V
L
A
------
Q
--
K
P
Y
S
K
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
Y
D
-
E
-
N
--
D
A
K
-
L
-
F
E
Q
I
L
K
A
E
Y
E
F
D
S
P
Y
W
D
D
I
S
D
S
A
K
D
F
I
R
H
L
M
E
K
D
P
E
K
R
F
T
C
E
Q
A
L
Q
H
P
W
I
A
G
D
T
------
A
L
D
--
K
N
I
H
-
Q
S
V
S
--
E
-
Q
I
K
K
N
F
A
K
S
K
W
K
Q
A
F
N
A
T
A
V
V
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
74
PsiBlast_CBE
67.50
36%
-105
- C2 -
2JAM
3
KCC1G_HUMAN
B:
[15-289]
---------------
E
V
L
G
S
G
A
F
S
E
V
F
L
V
K
Q
R
L
T
G
K
L
F
A
L
K
C
I
K
-----
K
--------
S
S
L
E
--
N
E
I
A
V
--
L
K
K
I
K
----
H
E
N
I
V
T
L
E
D
I
Y
E
S
T
T
H
Y
Y
L
V
M
Q
L
V
S
G
G
E
L
F
D
R
I
L
E
----------------------------------
R
G
----
V
Y
T
E
K
D
A
S
L
V
I
Q
Q
V
L
S
A
V
K
Y
L
H
E
N
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
L
T
P
E
-
E
N
S
K
-
I
M
I
T
D
F
G
L
S
-
K
M
E
Q
--
N
G
I
M
S
T
A
-
C
G
T
P
G
Y
V
A
P
E
V
L
A
------
Q
--
K
P
Y
S
K
A
V
D
C
W
S
I
G
V
I
T
Y
I
L
L
C
G
Y
P
P
F
Y
E
E
T
-
E
--
S
-
K
-
L
-
F
E
K
I
K
E
G
Y
Y
E
F
E
S
P
F
W
D
D
I
S
E
S
A
K
D
F
I
C
H
L
L
E
K
D
P
N
E
R
Y
T
C
E
K
A
L
S
H
P
W
I
D
G
N
T
------
A
L
H
--
R
D
I
Y
-
P
S
V
S
--
L
-
Q
I
Q
K
N
F
A
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
72
PsiBlast_CBE
66.70
38%
-117
- C2 -
3MA6
1
?
A:
[29-292]
------
I
F
S
D
R
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
--
S
K
R
Q
V
K
-
Q
-
K
T
D
K
E
S
L
L
--
R
E
V
Q
L
--
L
K
Q
L
D
----
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
----------------------------------
R
K
R
----
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
E
S
K
S
-
K
D
A
N
-
I
R
I
I
D
F
G
L
S
T
H
F
-
E
---
S
K
K
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
-------
H
--
G
T
Y
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
-
A
-
N
--
E
-
Y
D
I
-
L
K
K
V
E
K
G
K
Y
T
F
E
L
P
Q
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
A
R
D
A
L
D
H
E
W
I
Q
T
Y
T
------
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
107
PsiBlast_CBE
66.61
35%
-117
- C2 -
4TXC
7
DAPK1_HUMAN
A:
[29-296]
--------
D
D
Y
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
R
T
K
S
S
-
R
R
G
V
S
R
E
D
I
E
--
R
E
V
S
I
--
L
K
E
I
Q
----
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
-
F
D
F
L
A
----------------------------------
E
K
E
S
---
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
-
V
P
K
P
R
I
K
I
I
D
F
G
L
A
H
K
I
-
D
--
F
G
N
E
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
------
Y
--
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
-
K
--
Q
-
E
-
T
-
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
P
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
73
PsiBlast_CBE
66.42
37%
-107
- C2 -
2WEI
1
?
A:
[20-282]
-------
F
A
E
R
Y
N
I
V
C
M
L
G
K
G
S
F
G
E
V
L
K
C
K
D
R
I
T
Q
Q
E
Y
A
V
K
V
I
N
K
A
---
S
A
-
K
-
N
K
D
T
S
T
I
L
--
R
E
V
E
L
--
L
K
K
L
D
----
H
P
N
I
M
K
L
F
E
I
L
E
D
S
S
S
F
Y
I
V
G
E
L
Y
T
G
G
E
L
F
D
E
I
I
K
----------------------------------
R
K
R
----
F
S
E
H
D
A
A
R
I
I
K
Q
V
F
S
G
I
T
Y
M
H
K
H
N
I
V
H
R
D
L
K
P
E
N
I
L
L
E
S
K
E
-
K
D
C
D
-
I
K
I
I
D
F
G
L
S
T
C
F
Q
Q
--
N
T
K
M
K
D
-
R
I
G
T
A
Y
Y
I
A
P
E
V
L
-------
R
--
G
T
Y
D
E
K
C
D
V
W
S
A
G
V
I
L
Y
I
L
L
S
G
T
P
P
F
Y
G
-
K
-
N
--
E
-
Y
D
I
-
L
K
R
V
E
T
G
K
Y
A
F
D
L
P
Q
W
R
T
I
S
D
D
A
K
D
L
I
R
K
M
L
T
F
H
P
S
L
R
I
T
A
T
Q
C
L
E
H
P
W
I
Q
K
Y
S
------
S
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
98
PsiBlast_CBE
65.98
35%
-119
- C2 -
2YAK
1
DAPK1_HUMAN
A:
[10-278]
--------
D
D
Y
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
R
T
K
S
S
-
R
R
G
V
S
R
E
D
I
E
--
R
E
V
S
I
--
L
K
E
I
Q
----
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
-
F
D
F
L
A
----------------------------------
E
K
E
S
---
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
-
V
P
K
P
R
I
K
I
I
D
F
G
L
A
H
K
I
-
D
--
F
G
N
E
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
------
Y
--
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
-
K
--
Q
-
E
-
T
-
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
P
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
132
HHSearch
65.49
34%
-108
* C2 *
2Y0A
1
DAPK1_HUMAN
A:
[8-302]
------
N
V
D
D
Y
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
R
T
K
S
S
R
R
-
G
V
S
R
E
D
I
E
--
R
E
V
S
I
--
L
K
E
I
Q
----
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
----------------------------------
K
----
E
S
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
R
-
I
K
I
I
D
F
G
L
A
H
K
I
D
F
--
G
N
-
E
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
------
Y
--
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
-
D
T
K
--
Q
-
E
-
T
-
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
P
K
D
------
T
Q
Q
A
L
S
R
K
A
S
A
V
N
M
--
E
-
K
F
K
K
F
A
A
R
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
97
PsiBlast_CBE
64.45
35%
-127
- C2 -
3ZXT
1
DAPK1_HUMAN
A:
[10-276]
--------
D
D
Y
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
R
T
---------
R
E
D
I
E
--
R
E
V
S
I
--
L
K
E
I
Q
----
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
-
F
D
F
L
A
----------------------------------
E
K
E
S
---
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
--
V
P
K
P
R
I
K
I
I
D
F
G
L
A
H
K
I
-
D
--------------
E
F
V
A
P
E
I
V
N
------
Y
--
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
-
K
--
Q
-
E
-
T
-
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
94
PsiBlast_CBE
63.59
35%
-122
- C2 -
3ZXT
1
DAPK1_HUMAN
D:
[10-276]
--------
D
D
Y
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
------------
V
S
R
E
D
I
E
--
R
E
V
S
I
--
L
K
E
I
Q
----
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
-
F
D
F
L
A
----------------------------------
E
-------
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
-
V
P
K
P
R
I
K
I
I
D
F
G
L
A
H
K
I
-
D
------------
T
P
E
F
V
A
P
E
I
V
N
------
Y
--
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
-
K
--
Q
-
E
-
T
-
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
71
PsiBlast_CBE
63.47
38%
-115
- C2 -
3MA6
1
?
B:
[29-292]
------
I
F
S
D
R
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
--
S
K
R
Q
V
K
-
Q
--
T
D
K
E
S
L
L
--
R
E
V
Q
L
--
L
K
Q
L
D
----
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
----------------------------------
R
K
R
----
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
E
S
K
S
-
K
D
A
N
-
I
R
I
I
D
F
G
L
S
T
H
F
-
E
--
A
S
K
K
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
-------
H
--
G
T
Y
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
-
A
-
N
--
E
-
Y
D
I
-
L
K
K
V
E
K
G
K
Y
T
F
E
L
P
Q
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
A
R
D
A
L
D
H
E
W
I
Q
T
Y
T
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
96
PsiBlast_CBE
63.04
35%
-118
- C2 -
3ZXT
1
DAPK1_HUMAN
B:
[10-276]
--------
D
D
Y
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
R
T
K
S
--
R
R
G
V
S
R
E
D
I
E
--
R
E
V
S
I
--
L
K
E
I
Q
----
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
-
F
D
F
L
A
----------------------------------
E
K
-----
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
-
V
P
K
P
R
I
K
I
I
D
F
G
L
A
H
K
I
-
D
------------
T
P
E
F
V
A
P
E
I
V
N
------
Y
--
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
-
S
G
A
S
P
F
L
G
D
T
-
K
--
Q
-
E
-
T
-
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
---
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
95
PsiBlast_CBE
62.79
35%
-123
- C2 -
3ZXT
1
DAPK1_HUMAN
C:
[10-276]
--------
D
D
Y
Y
D
T
G
E
E
L
G
--
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
R
T
K
S
S
-
R
R
G
V
S
R
E
D
I
E
--
R
E
V
S
I
--
L
K
E
I
Q
----
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
-
F
D
F
L
A
----------------------------------
E
K
E
S
---
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
-
V
P
K
P
R
I
K
I
I
D
F
G
L
A
H
K
I
-
D
-------------
P
E
F
V
A
P
E
I
V
N
------
Y
--
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
-
K
--
Q
-
E
-
T
-
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------