@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : CTRO_HUMAN: (2015-10-06 )
MLKFKYGARNPLDAGAAEPIASRASRLNLFFQGKPPFMTQQQMSPLSREGILDALFVLFEECSQPALMKIKHVSNFVRKYSDTIAELQELQPSAKDFEVRSLVGCGHFAEVQVVREKATGDIYAMKVMKKKALLAQEQVSFFEEERNILSRSTSPWIPQLQYAFQDKNHLYLVMEYQPGGDLLSLLNRYEDQLDENLIQFYLAELILAVHSVHLMGYVHRDIKPENILVDRTGHIKLVDFGSAAKMNSNKMVNAKLPIGTPDYMAPEVLTVMNGDGKGTYGLDCDWWSVGVIAYEMIYGRSPFAEGTSARTFNNIMNFQRFLKFPDDPKVSSDFLDLIQSLLCGQKERLKFEGLCCHPFFSKIDWNNIRNSPPPFVPTLKSDDDTSNFDEPEKNSWVSSSPCQLSPSGFSGEELPFVGFSYSKALGILGRSESVVSGLDSPAKTSSMEKKLLIKSKELQDSQDKCHKMEQEMTRLHRRVSEVEAVLSQKEVELKASETQRSLLEQDLATYITECSSLKRSLEQARMEVSQEDDKALQLLHDIREQSRKLQEIKEQEYQAQVEEMRLMMNQLEEDLVSARRRSDLYESELRESRLAAEEFKRKATECQHKLLKAKDQGKPEVGEYAKLEKINAEQQLKIQELQEKLEKAVKASTEATELLQNIRQAKERAERELEKLQNREDSSEGIRKKLVEAEELEEKHREAQVSAQHLEVHLKQKEQHYEEKIKVLDNQIKKDLADKETLENMMQRHEEEAHEKGKILSEQKAMINAMDSKIRSLEQRIVELSEANKLAANSSLFTQRNMKAQEEMISELRQQKFYLETQAGKLEAQNRKLEEQLEKISHQDHSDKNRLLELETRLREVSLEHEEQKLELKRQLTELQLSLQERESQLTALQAARAALESQLRQAKTELEETTAEAEEEIQALTAHRDEIQRKFDALRNSCTVITDLEEQLNQLTEDNAELNNQNFYLSKQLDEASGANDEIVQLRSEVDHLRREITEREMQLTSQKQTMEALKTTCTMLEEQVMDLEALNDELLEKERQWEAWRSVLGDEKSQFECRVRELQRMLDTEKQSRARADQRITESRQVVELAVKEHKAEILALQQALKEQKLKAESLSDKLNDLEKKHAMLEMNARSLQQKLETERELKQRLLEEQAKLQQQMDLQKNHIFRLTQGLQEALDRADLLKTERSDLEYQLENIQVLYSHEKVKMEGTISQQTKLIDFLQAKMDQPAKKKKGLFSRRKEDPALPTQVPLQYNELKLALEKEKARCAELEEALQKTRIELRSAREEAAHRKATDHPHPSTPATARQQIAMSAIVRSPEHQPSAMSLLAPPSSRRKESSTPEEFSRRLKERMHHNIPHRFNVGLNMRATKCAVCLDTVHFGRQASKCLECQVMCHPKCSTCLPATCGLPAEYATHFTEAFCRDKMNSPGLQTKEPSSSLHLEGWMKVPRNNKRGQQGWDRKYIVLEGSKVLIYDNEAREAGQRPVEEFELCLPDGDVSIHGAVGASELANTAKADVPYILKMESHPHTTCWPGRTLYLLAPSFPDKQRWVTALESVVAGGRVSREKAEADAKLLGNSLLKLEGDDRLDMNCTLPFSDQVVLVGTEEGLYALNVLKNSLTHVPGIGAVFQIYIIKDLEKLLMIAGEERALCLVDVKKVKQSLAQSHLPAQPDISPNIFEAVKGCHLFGAGKIENGLCICAAMPSKVVILRYNENLSKYCIRKEIETSEPCSCIHFTNYSILIGTNKFYEIDMKQYTLEEFLDKNDHSLAPAVFAASSNSFPVSIVQVNSAGQREEYLLCFHEFGVFVDSYGRRSRTDDLKWSRLPLAFAYREPYLFVTHFNSLEVIEIQARSSAGTPARAYLDIPNPRYLGPAISSGAIYLASSYQDKLRVICCKGNLVKESGTEHHRGPSTSRSSPNKRGPPTYNEHITKRVASSPAPPEGPSHPREPSTPHRYREGRTELRRDKSPGRPLEREKSPGRMLSTRRERSPGRLFEDSSRGRLPAGAVRTPLSQVNKVWDQSSV
Atome Classification :
(52 SA)
.........10........20........30..--......40..---------......50........60........70........80........90....--....100.......110.....---..120.......130....-...140.......150-..-.....160.......170.......180.......190.......200.......210..-.....220.......230.......240.......250.......260.......270.......280.......290.......300.......310....----...320...-----.--.-..330...--....340--.....-....---350-----...--------......360.--.....--..--.370-........380.......390.......400.....--...410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770.......780.......790.......800.......810.......820.......830.......840.......850.......860.......870.......880.......890.......900.......910.......920.......930.......940.......950.......960.......970.......980.......990.......1000......1010......1020......1030......1040......1050......1060......1070......1080......1090......1100......1110......1120......1130......1140......1150......1160......1170......1180......1190......1200......1210......1220......1230......1240......1250......1260......1270......1280......1290......1300......1310......1320......1330......1340......1350......1360......1370......1380......1390......1400......1410......1420......1430......1440......1450......1460......1470......1480......1490......1500......1510......1520......1530......1540......1550......1560......1570......1580......1590......1600......1610......1620......1630......1640......1650......1660......1670......1680......1690......1700......1710......1720......1730......1740......1750......1760......1770......1780......1790......1800......1810......1820......1830......1840......1850......1860......1870......1880......1890......1900......1910......1920......1930......1940......1950......1960......1970......1980......1990......2000......2010......2020....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
L
K
F
KYGARNPLDAGAA
E
P
I
A
S
R
A
S
R
L
N
L
F
FQG--KPPF
M
T
Q
Q
QM---------SPLSRE
G
I
L
D
A
L
F
V
L
F
E
ECSQ
P
A
L
M
K
I
K
H
V
S
N
F
V
R
K
Y
S
D
T
I
A
E
L
Q
E
LQPSAK--DF
E
V
R
S
LVGCG
H
F
A
E
V
Q
V
V
R
EK---ATG
D
I
Y
A
M
K
V
M
K
K
K
A
L
L
A
Q
-
E
Q
V
S
F
F
E
E
E
R
N
I
L
SRS-TS-PWI
P
Q
L
Q
Y
A
FQDKN
H
L
Y
L
V
M
E
YQPG
G
D
L
L
S
L
L
N
R
Y
E
D
Q
L
D
E
N
L
I
Q
F
Y
L
A
E
L
I
L
A
V
H
S
V
H
L
-
M
G
Y
V
HRDIKPE
N
I
L
VDRTG
H
I
K
L
V
DFGSAAKMNSN
K
M
V
N
AKLPIGTPDYMA
P
E
V
L
T
V
MNGDGKGTYGLDC
D
W
W
S
V
G
V
I
A
Y
E
M
I
YGRSPFAEGTSA
R
T
F
N
N
I
M
----
N
F
Q
R
F
LKFP-----D--D-PKV
S
S
D
F
L
--
D
L
I
Q
S
----
L
LCG
Q
-
K
E
R
L
---
K
-------FEG--------LCC
H
P
F
F
--
S
--KIDWN--NI--RNS--PPPFVPTLKSDDDTSNFDEPEKNSWVSSS-PCQLSP--SGFSGEEL
P
F
VGF
S
Y
S
K
A
L
GILGR
S
E
S
V
V
SGLDSPAK
T
S
S
M
E
K
K
L
L
I
K
S
K
ELQ
D
S
Q
D
K
C
H
K
M
E
Q
E
M
T
R
L
H
R
R
V
S
E
V
E
A
V
L
S
Q
K
E
V
E
L
K
A
S
E
T
Q
R
S
L
L
E
Q
D
L
A
T
Y
I
T
E
C
S
S
L
K
R
S
L
E
Q
A
R
M
EVSQE
D
D
K
A
L
Q
L
L
H
D
I
R
E
Q
S
R
K
L
Q
E
I
K
E
Q
E
Y
Q
A
Q
V
E
E
M
R
L
M
M
N
Q
L
E
E
D
L
V
S
A
R
R
RS
D
L
Y
E
S
E
L
R
E
S
R
L
A
A
E
E
F
K
R
K
A
T
E
C
Q
H
K
L
L
KAKDQGKPEV
G
E
Y
A
K
L
E
KI
N
A
E
Q
Q
L
K
I
Q
E
L
Q
E
K
L
E
K
A
V
KAST
E
A
T
E
L
L
Q
N
I
R
Q
A
K
E
R
A
E
R
E
L
E
K
L
QNRED
S
S
E
G
I
R
K
K
L
V
E
A
E
E
L
E
E
K
H
R
E
AQV
S
A
Q
H
L
E
V
H
L
K
Q
K
E
Q
H
Y
E
E
K
I
K
V
L
D
N
Q
I
K
K
D
LA
D
K
E
T
L
E
N
M
M
Q
R
H
E
E
E
A
H
E
KG
K
I
L
S
E
Q
K
A
M
I
N
A
M
D
S
K
I
R
S
L
E
Q
R
I
V
E
L
S
E
A
NKLAANSS
L
F
T
QRN
M
K
A
Q
E
E
M
I
S
E
L
R
QQ
K
F
Y
L
ETQAGKL
E
A
Q
N
R
K
L
E
E
Q
L
E
K
I
SHQDHSD
K
N
R
L
L
E
L
E
T
R
L
R
E
VS
L
E
H
E
E
Q
K
L
E
L
K
R
Q
L
T
E
L
Q
L
S
L
Q
E
R
E
S
Q
L
T
A
L
Q
A
A
R
A
A
L
E
S
Q
L
R
Q
A
K
T
E
L
E
E
T
T
A
E
A
E
E
E
I
Q
A
L
T
A
H
R
D
E
I
Q
R
K
F
D
A
L
RNS
C
T
V
I
T
D
L
E
E
Q
L
N
Q
L
T
EDNAELNNQ
N
F
Y
L
S
KQLDEASGAN
D
E
I
V
Q
L
R
S
E
V
D
H
L
R
R
E
I
T
E
R
E
M
Q
L
T
S
Q
K
Q
T
M
E
A
L
K
T
T
C
T
M
L
E
E
Q
V
M
D
L
E
AL
N
D
E
L
L
E
K
E
R
Q
W
E
A
W
R
S
V
LGDE
K
S
Q
F
E
C
R
V
R
E
L
Q
R
M
L
D
T
E
K
Q
S
R
A
R
A
D
Q
R
I
T
E
S
R
Q
V
V
E
L
A
V
K
E
H
K
A
E
I
L
A
L
Q
Q
A
L
K
E
QKL
K
A
E
S
L
S
D
K
L
N
D
L
E
K
K
H
A
M
L
E
M
N
A
R
S
L
Q
Q
K
L
E
T
E
R
E
L
K
Q
R
L
L
E
E
Q
A
K
L
Q
Q
Q
M
D
L
Q
K
N
H
I
F
R
L
T
Q
G
L
Q
E
A
L
D
R
A
D
L
L
K
TERS
D
L
E
Y
Q
LE
N
I
Q
V
L
Y
SH
E
K
V
K
MEGTI
S
Q
Q
T
K
L
I
D
F
L
Q
A
KMDQ
P
A
K
K
K
K
G
L
F
S
RRKEDPALPTQVPL
Q
Y
N
E
L
K
L
A
L
E
K
E
K
A
R
C
A
E
L
E
E
A
L
Q
K
T
R
I
E
L
R
S
A
R
E
E
A
AHRKATDHPHPST
P
A
T
A
R
Q
Q
I
A
M
S
A
I
VRSPEHQPSA
M
S
L
LAPPSSRRKESS
T
P
E
E
F
S
R
R
L
K
E
R
M
HHNIP
H
R
F
NVGLNMR
A
T
K
C
A
V
C
L
D
T
V
H
F
G
R
Q
A
S
K
C
L
E
C
Q
V
M
CHPKCSTCLPATCGL
P
A
E
Y
A
T
H
F
T
E
A
F
C
R
DKMNSPGLQTKEPSSSLH
L
E
G
W
MKVPRNNKRGQQGW
D
R
K
Y
I
V
L
EG
S
K
V
L
I
YDN
E
A
R
EAGQR
P
V
E
E
F
E
L
CLPDG
D
V
S
I
H
GAV
G
A
S
E
L
ANTAKADV
P
Y
I
L
K
MESHPHTTCWPG
R
T
L
Y
L
LAPSFP
D
K
Q
R
W
V
T
A
L
E
S
V
V
AGGRVS
R
E
K
A
E
A
D
A
K
L
L
GN
S
L
L
KLEGDDRLDMNCTLPFSD
Q
V
V
L
V
GTEE
G
L
Y
A
L
N
V
L
K
N
S
LTHVPGI
G
A
V
F
Q
I
Y
I
I
K
D
L
E
K
L
L
M
IAGEE
R
A
L
C
L
V
D
V
K
K
V
K
Q
S
L
A
Q
SHLPAQPDIS
P
N
I
F
E
A
V
KG
C
H
L
FGAGKIEN
G
L
C
I
C
AAMP
S
K
V
V
I
L
R
YNE
N
L
S
K
Y
C
I
R
K
EIETSEP
C
S
C
I
H
FT
N
Y
S
I
L
IGTN
K
F
Y
E
I
D
M
K
Q
Y
T
L
E
E
F
LDKNDHSLA
P
A
V
F
AASSNSF
P
V
S
I
V
Q
VNSAGQRE
E
Y
L
L
C
F
H
E
F
G
V
F
V
D
SYGRRSRTDDLKWSRL
P
L
A
F
A
YRE
P
Y
L
F
V
T
HFNS
L
E
V
I
E
I
Q
ARSSAGTP
A
R
A
Y
LDIPNPRYLGPAISS
G
A
I
Y
L
ASSYQD
K
L
R
V
I
C
CKGNLVKESGTEHHRGPSTSRSSPNKRGPP
T
Y
N
E
H
I
T
K
R
V
ASSPAPPEGPSHPREPST
P
H
R
Y
R
E
G
R
T
E
L
RRDKSPGRPLEREKSPG
R
M
L
S
T
R
RERSPGRLFEDSSRGRLPA
G
A
VR
T
P
L
S
Q
V
N
K
V
WDQSSV
21
PsiBlast_CBE
96.52
43%
-65
- C3 -
3TKU
3
MRCKB_HUMAN
B:
[18-420]
---------------------------------SA
K
V
R
L
K
K
L
E
Q
L
LLDGPWRNE
S
A
L
S
V
E
T
L
L
D
V
L
V
C
L
Y
T
E
C
S
H
S
A
L
R
R
D
K
Y
V
A
E
F
L
E
W
A
K
P
F
T
Q
L
V
K
E
M
Q
L
H
R
E
--
D
F
E
I
I
K
V
I
G
R
G
A
F
G
E
V
A
V
V
K
M
K
---
N
T
E
R
I
Y
A
M
K
I
L
N
K
W
E
M
L
K
R
-
A
E
T
A
C
F
R
E
E
R
D
V
L
V
N
G
-
D
C
-
Q
W
I
T
A
L
H
Y
A
F
Q
D
E
N
H
L
Y
L
V
M
D
Y
Y
V
G
G
D
L
L
T
L
L
S
K
F
E
D
K
L
P
E
D
M
A
R
F
Y
I
G
E
M
V
L
A
I
D
S
I
H
Q
-
L
H
Y
V
H
R
D
I
K
P
D
N
V
L
L
D
V
N
G
H
I
R
L
A
D
F
G
S
C
L
K
M
N
D
D
G
T
V
Q
S
S
V
A
V
G
T
P
D
Y
I
S
P
E
I
L
Q
A
M
E
-
D
G
M
G
K
Y
G
P
E
C
D
W
W
S
L
G
V
C
M
Y
E
M
L
Y
G
E
T
P
F
Y
A
E
S
L
V
E
T
Y
G
K
I
M
----
N
H
E
E
R
F
Q
F
P
-----
S
--
H
V
T
D
V
S
E
E
A
K
--
D
L
I
Q
R
----
L
I
C
S
R
-
E
R
R
L
GQN
G
-------
I
E
D
--------
F
K
K
H
A
F
F
--
E
--
G
L
N
W
E
--
N
I
--
R
N
L
--
E
A
P
Y
I
P
D
V
S
S
P
S
D
T
S
N
F
D
----------------------
F
S
G
L
H
L
P
F
I
G
F
T
F
T
T
E
S
C
F
S
D
R
G
S
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
95.86
44%
-72
- C3 -
4UAK
2
MRCKB_HUMAN
A:
[25-406]
------------------------------------------------------
S
A
L
S
V
E
T
L
L
D
V
L
V
C
L
Y
T
E
C
S
H
S
A
L
R
R
D
K
Y
V
A
E
F
L
E
W
A
K
P
F
T
Q
L
V
K
E
M
Q
L
H
R
E
--
D
F
E
I
I
K
V
I
G
R
G
A
F
G
E
V
A
V
V
K
M
K
---
N
T
E
R
I
Y
A
M
K
I
L
N
K
W
E
M
L
K
R
-
A
E
T
A
C
F
R
E
E
R
D
V
L
V
N
G
-
D
C
-
Q
W
I
T
A
L
H
Y
A
F
Q
D
E
N
H
L
Y
L
V
M
D
Y
Y
V
G
G
D
L
L
T
L
L
S
K
F
E
D
K
L
P
E
D
M
A
R
F
Y
I
G
E
M
V
L
A
I
D
S
I
H
Q
-
L
H
Y
V
H
R
D
I
K
P
D
N
V
L
L
D
V
N
G
H
I
R
L
A
D
F
G
S
C
L
K
M
N
D
D
G
T
V
Q
S
S
V
A
V
G
T
P
D
Y
I
S
P
E
I
L
Q
A
M
E
-
D
G
M
G
K
Y
G
P
E
C
D
W
W
S
L
G
V
C
M
Y
E
M
L
Y
G
E
T
P
F
Y
A
E
S
L
V
E
T
Y
G
K
I
M
----
N
H
E
E
R
F
Q
F
P
-----
S
--
H
V
T
D
V
S
E
E
A
K
--
D
L
I
Q
R
----
L
I
C
S
R
-
E
R
R
L
GQN
G
-------
I
E
D
--------
F
K
K
H
A
F
F
--
E
--
G
L
N
W
E
--
N
I
--
R
N
L
--
E
A
P
Y
I
P
D
V
S
S
P
S
D
T
S
N
F
D
------------------SH
T
G
F
S
G
L
H
L
P
F
I
G
F
T
F
T
T
E
S
C
F
S
D
R
G
S
L
K
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
95.72
43%
-61
- C3 -
3TKU
3
MRCKB_HUMAN
A:
[18-420]
---------------------------------S
A
K
V
R
L
K
K
L
E
Q
L
L
L
D
GPWRNE
S
A
L
S
V
E
T
L
L
D
V
L
V
C
L
Y
T
E
C
S
H
S
A
L
R
R
D
K
Y
V
A
E
F
L
E
W
A
K
P
F
T
Q
L
V
K
E
M
Q
L
H
R
E
--
D
F
E
I
I
K
V
I
G
R
G
A
F
G
E
V
A
V
V
K
M
K
---
N
T
E
R
I
Y
A
M
K
I
L
N
K
W
E
M
L
K
R
-
A
E
T
A
C
F
R
E
E
R
D
V
L
V
N
G
-
D
C
-
Q
W
I
T
A
L
H
Y
A
F
Q
D
E
N
H
L
Y
L
V
M
D
Y
Y
V
G
G
D
L
L
T
L
L
S
K
F
E
D
K
L
P
E
D
M
A
R
F
Y
I
G
E
M
V
L
A
I
D
S
I
H
Q
-
L
H
Y
V
H
R
D
I
K
P
D
N
V
L
L
D
V
N
G
H
I
R
L
A
D
F
G
S
C
L
K
M
N
D
D
G
T
V
Q
S
S
V
A
V
G
T
P
D
Y
I
S
P
E
I
L
Q
A
M
E
-
D
G
M
G
K
Y
G
P
E
C
D
W
W
S
L
G
V
C
M
Y
E
M
L
Y
G
E
T
P
F
Y
A
E
S
L
V
E
T
Y
G
K
I
M
----
N
H
E
E
R
F
Q
F
P
-----
S
--
H
V
T
D
V
S
E
E
A
K
--
D
L
I
Q
R
----
L
I
C
S
R
-
E
R
R
L
GQN
G
-------
I
E
D
--------
F
K
K
H
A
F
F
--
E
--
G
L
N
W
E
--
N
I
--
R
N
L
--
E
A
P
Y
I
P
D
V
S
S
P
S
D
T
S
N
F
D
V
----------------------
S
G
L
H
L
P
F
I
G
F
T
F
T
T
E
S
C
F
S
D
R
G
S
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28
PsiBlast_CBE
95.05
43%
-64
- C3 -
4YVC
1
ROCK1_HUMAN
B:
[23-399]
------------------------------------------------------
S
E
V
N
S
D
C
L
L
D
G
L
D
A
L
V
Y
D
L
D
F
P
A
L
R
K
N
K
N
I
D
N
F
L
S
R
Y
K
D
T
I
N
K
I
R
D
L
R
M
K
A
E
--
D
Y
E
V
V
K
V
I
G
R
G
A
F
G
E
V
Q
L
V
R
H
K
---
S
T
R
K
V
Y
A
M
K
L
L
S
K
F
E
M
I
K
R
-
S
D
S
A
F
F
W
E
E
R
D
I
M
A
F
A
-
N
S
-
P
W
V
V
Q
L
F
Y
A
F
Q
D
D
R
Y
L
Y
M
V
M
E
Y
M
P
G
G
D
L
V
N
L
M
S
N
Y
D
--
V
P
E
K
W
A
R
F
Y
T
A
E
V
V
L
A
L
D
A
I
H
S
-
M
G
F
I
H
R
D
V
K
P
D
N
M
L
L
D
K
S
G
H
L
K
L
A
D
F
G
T
C
M
K
M
N
K
E
G
M
V
R
C
D
T
A
V
G
T
P
D
Y
I
S
P
E
V
L
K
S
Q
G
G
D
--
G
Y
Y
G
R
E
C
D
W
W
S
V
G
V
F
L
Y
E
M
L
V
G
D
T
P
F
Y
A
D
S
L
V
G
T
Y
S
K
I
M
----
N
H
K
N
S
L
T
F
P
-----
D
--
D
-
N
D
I
S
K
E
A
K
--
N
L
I
C
A
----
F
L
T
D
R
-
E
V
R
L
---
G
-------
R
N
G
V
E
E
-----
I
K
R
H
L
F
F
--
K
ND
Q
W
A
W
E
--
T
L
--
R
D
T
--
V
A
P
V
V
P
D
L
S
S
D
I
D
T
S
N
F
D
D
L
------
E
E
T
F
P
I
---
P
--
K
A
F
V
G
N
Q
L
P
F
V
G
F
T
Y
Y
S
N
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
94.79
44%
-67
- C3 -
4UAL
2
MRCKB_HUMAN
A:
[25-406]
------------------------------------------------------
S
A
L
S
V
E
T
L
L
D
V
L
V
C
L
Y
T
E
C
S
H
S
A
L
R
R
D
K
Y
V
A
E
F
L
E
W
A
K
P
F
T
Q
L
V
K
E
M
Q
L
H
R
E
--
D
F
E
I
I
K
V
I
G
R
G
A
F
G
E
V
A
V
V
K
M
K
---
N
T
E
R
I
Y
A
M
K
I
L
N
K
W
E
M
L
K
R
-
A
E
T
A
C
F
R
E
E
R
D
V
L
V
N
G
-
D
C
-
Q
W
I
T
A
L
H
Y
A
F
Q
D
E
N
H
L
Y
L
V
M
D
Y
Y
V
G
G
D
L
L
T
L
L
S
K
F
E
D
K
L
P
E
D
M
A
R
F
Y
I
G
E
M
V
L
A
I
D
S
I
H
Q
-
L
H
Y
V
H
R
D
I
K
P
D
N
V
L
L
D
V
N
G
H
I
R
L
A
D
F
G
S
C
L
K
M
N
D
D
G
T
V
---
V
A
V
G
T
P
D
Y
I
S
P
E
I
L
Q
A
M
E
-
D
--
G
K
Y
G
P
E
C
D
W
W
S
L
G
V
C
M
Y
E
M
L
Y
G
E
T
P
F
Y
A
E
S
L
V
E
T
Y
G
K
I
M
----
N
H
E
E
R
F
Q
F
P
-----
S
--
H
V
T
D
V
S
E
E
A
K
--
D
L
I
Q
R
----
L
I
C
S
R
-
E
R
R
L
GQN
G
-------
I
E
D
--------
F
K
K
H
A
F
F
--
E
--
G
L
N
W
E
--
N
I
--
R
N
L
--
E
A
P
Y
I
P
D
V
S
S
P
S
D
T
S
N
F
D
V
-------------
I
L
P
P
H-
T
G
F
S
G
L
H
L
P
F
I
G
F
T
F
T
T
E
S
C
F
S
D
R
G
S
L
K
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
94.56
43%
-65
- C3 -
4YVC
1
ROCK1_HUMAN
A:
[23-399]
------------------------------------------------------
S
E
V
N
S
D
C
L
L
D
G
L
D
A
L
V
Y
D
L
D
F
P
A
L
R
K
N
K
N
I
D
N
F
L
S
R
Y
K
D
T
I
N
K
I
R
D
L
R
M
K
A
E
--
D
Y
E
V
V
K
V
I
G
R
G
A
F
G
E
V
Q
L
V
R
H
K
---
S
T
R
K
V
Y
A
M
K
L
L
S
K
F
E
M
I
K
------
F
F
W
E
E
R
D
I
M
A
F
A
-
N
S
-
P
W
V
V
Q
L
F
Y
A
F
Q
D
D
R
Y
L
Y
M
V
M
E
Y
M
P
G
G
D
L
V
N
L
M
S
N
Y
D
--
V
P
E
K
W
A
R
F
Y
T
A
E
V
V
L
A
L
D
A
I
H
S
-
M
G
F
I
H
R
D
V
K
P
D
N
M
L
L
D
K
S
G
H
L
K
L
A
D
F
G
T
C
M
K
M
N
K
E
G
M
V
R
C
D
T
A
V
G
T
P
D
Y
I
S
P
E
V
L
K
S
Q
G
G
D
--
G
Y
Y
G
R
E
C
D
W
W
S
V
G
V
F
L
Y
E
M
L
V
G
D
T
P
F
Y
A
D
S
L
V
G
T
Y
S
K
I
M
----
N
H
K
N
S
L
T
F
P
-----
D
--
D
-
N
D
I
S
K
E
A
K
--
N
L
I
C
A
----
F
L
T
D
R
-
E
V
R
L
---
G
-------
R
N
G
V
E
E
-----
I
K
R
H
L
F
F
--
K
ND
Q
W
A
W
E
--
T
L
--
R
D
T
--
V
A
P
V
V
P
D
L
S
S
D
I
D
T
S
N
F
D
D
L
-------
E
T
F
P
I
---
P
--
K
A
F
V
G
N
Q
L
P
F
V
G
F
T
Y
Y
S
N
R
R
Y
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
94.43
44%
-62
- C3 -
3QFV
2
MRCKB_HUMAN
A:
[23-404]
------------------------------------------------------
S
A
L
S
V
E
T
L
L
D
V
L
V
C
L
Y
T
E
C
S
H
S
A
L
R
R
D
K
Y
V
A
E
F
L
E
W
A
K
P
F
T
Q
L
V
K
E
M
Q
L
H
R
E
--
D
F
E
I
I
K
V
I
G
R
G
A
F
G
E
V
A
V
V
K
M
K
---
N
T
E
R
I
Y
A
M
K
I
L
N
K
W
E
M
L
K
R
-
A
E
T
A
C
F
R
E
E
R
D
V
L
V
N
G
-
D
C
-
Q
W
I
T
A
L
H
Y
A
F
Q
D
E
N
H
L
Y
L
V
M
D
Y
Y
V
G
G
D
L
L
T
L
L
S
K
F
E
D
K
L
P
E
D
M
A
R
F
Y
I
G
E
M
V
L
A
I
D
S
I
H
Q
-
L
H
Y
V
H
R
D
I
K
P
D
N
V
L
L
D
V
N
G
H
I
R
L
A
D
F
G
S
C
L
K
M
N
D
D
G
T
V
Q
S
S
V
A
V
G
T
P
D
Y
I
S
P
E
I
L
Q
A
M
E
-
D
G
M
G
K
Y
G
P
E
C
D
W
W
S
L
G
V
C
M
Y
E
M
L
Y
G
E
T
P
F
Y
A
E
S
L
V
E
T
Y
G
K
I
M
----
N
H
E
E
R
F
Q
F
P
-----
S
--
H
V
T
D
V
S
E
E
A
K
--
D
L
I
Q
R
----
L
I
C
S
R
-
E
R
R
L
GQN
G
-------
I
E
D
--------
F
K
K
H
A
F
F
--
E
--
G
L
N
W
E
--
N
I
--
R
N
L
--
E
A
P
Y
I
P
D
V
S
S
P
S
D
T
S
N
F
D
V
----------------------
S
G
L
H
L
P
F
I
G
F
T
F
T
T
E
S
C
F
S
D
R
G
S
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
94.30
44%
-68
- C3 -
3QFV
3
MRCKB_HUMAN
B:
[23-404]
------------------------------------------------------
S
A
L
S
V
E
T
L
L
D
V
L
V
C
L
Y
T
E
C
S
H
S
A
L
R
R
D
K
Y
V
A
E
F
L
E
W
A
K
P
F
T
Q
L
V
K
E
M
Q
L
H
R
E
--
D
F
E
I
I
K
V
I
G
R
G
A
F
G
E
V
A
V
V
K
M
K
---
N
T
E
R
I
Y
A
M
K
I
L
N
K
W
E
M
L
K
R
-
A
E
T
A
C
F
R
E
E
R
D
V
L
V
N
G
-
D
C
-
Q
W
I
T
A
L
H
Y
A
F
Q
D
E
N
H
L
Y
L
V
M
D
Y
Y
V
G
G
D
L
L
T
L
L
S
K
F
E
D
K
L
P
E
D
M
A
R
F
Y
I
G
E
M
V
L
A
I
D
S
I
H
Q
-
L
H
Y
V
H
R
D
I
K
P
D
N
V
L
L
D
V
N
G
H
I
R
L
A
D
F
G
S
C
L
K
M
N
D
D
G
T
V
Q
S
S
V
A
V
G
T
P
D
Y
I
S
P
E
I
L
Q
A
M
E
-
D
G
M
G
K
Y
G
P
E
C
D
W
W
S
L
G
V
C
M
Y
E
M
L
Y
G
E
T
P
F
Y
A
E
S
L
V
E
T
Y
G
K
I
M
----
N
H
E
E
R
F
Q
F
P
-----
S
--
H
V
T
D
V
S
E
E
A
K
--
D
L
I
Q
R
----
L
I
C
S
R
-
E
R
R
L
GQN
G
-------
I
E
D
--------
F
K
K
H
A
F
F
--
E
--
G
L
N
W
E
--
N
I
--
R
N
L
--
E
A
P
Y
I
P
D
V
S
S
P
S
D
T
S
N
F
D
---------------------
G
F
S
G
L
H
L
P
F
I
G
F
T
F
T
T
E
S
C
F
S
D
R
G
S
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
94.07
43%
-62
- C3 -
4AW2
4
MRCKA_RAT
A:
[25-413]
--------------------------------------------------------
F
S
V
E
T
L
L
D
I
L
I
C
L
Y
D
E
C
N
N
S
P
L
R
R
E
K
N
I
L
E
Y
L
E
W
A
K
P
F
T
S
K
V
K
Q
M
R
L
H
R
E
--
D
F
E
I
L
K
V
I
G
R
G
A
F
G
E
V
A
V
V
K
L
K
---
N
A
D
K
V
F
A
M
K
I
L
N
K
W
E
M
L
K
R
-
A
E
T
A
C
F
R
E
E
R
D
V
L
V
N
G
-
D
S
-
K
W
I
T
T
L
H
Y
A
F
Q
D
D
N
N
L
Y
L
V
M
D
Y
Y
V
G
G
D
L
L
T
L
L
S
K
F
E
D
R
L
P
E
E
M
A
R
F
Y
L
A
E
M
V
I
A
I
D
S
V
H
Q
-
L
H
Y
V
H
R
D
I
K
P
D
N
I
L
M
D
M
N
G
H
I
R
L
A
D
F
G
S
C
L
K
L
M
E
D
G
T
V
Q
S
S
V
A
V
G
T
P
D
Y
I
S
P
E
I
L
Q
A
M
E
G
-
G
K
G
R
Y
G
P
E
C
D
W
W
S
L
G
V
C
M
Y
E
M
L
Y
G
E
T
P
F
Y
A
E
S
L
V
E
T
Y
G
K
I
M
----
N
H
K
E
R
F
Q
F
P
-----
T
--
Q
V
T
D
V
S
E
N
A
K
--
D
L
I
R
R
----
L
I
C
S
R
-
E
H
R
L
GQN
G
-------
I
E
D
--------
F
K
K
H
P
F
F
--
S
--
G
I
D
W
D
--
N
I
--
R
N
C
--
E
A
P
Y
I
P
E
V
S
S
P
T
D
T
S
N
F
D
V
D
---------------------
S
G
H
H
L
P
F
V
G
F
T
Y
T
S
S
C
V
L
S
D
R
S
C
L
R
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
49
PsiBlast_CBE
93.29
43%
-61
- C3 -
4L6Q
1
ROCK2_HUMAN
B:
[24-402]
------------------------------------------------------
S
P
I
N
V
E
S
L
L
D
G
L
N
S
L
V
L
D
L
D
F
P
A
L
R
K
N
K
N
I
D
N
F
L
N
R
Y
E
K
I
V
K
K
I
R
G
L
Q
M
K
A
E
--
D
Y
D
V
V
K
V
I
G
R
G
A
F
G
E
V
Q
L
V
R
H
K
---
A
S
Q
K
V
Y
A
M
K
L
L
S
K
F
E
M
I
K
R
-
S
D
S
A
F
F
W
E
E
R
D
I
M
A
F
A
-
N
S
-
P
W
V
V
Q
L
F
Y
A
F
Q
D
D
R
Y
L
Y
M
V
M
E
Y
M
P
G
G
D
L
V
N
L
M
S
N
Y
D
--
V
P
E
K
W
A
K
F
Y
T
A
E
V
V
L
A
L
D
A
I
H
S
-
M
G
L
I
H
R
D
V
K
P
D
N
M
L
L
D
K
H
G
H
L
K
L
A
D
F
G
T
C
M
K
M
D
E
T
G
M
V
H
C
D
T
A
V
G
T
P
D
Y
I
S
P
E
V
L
K
S
Q
G
G
D
--
G
F
Y
G
R
E
C
D
W
W
S
V
G
V
F
L
Y
E
M
L
V
G
D
T
P
F
Y
A
D
S
L
V
G
T
Y
S
K
I
M
----
D
H
K
N
S
L
C
F
P
-----
E
--
D
-
A
E
I
S
K
H
A
K
--
N
L
I
C
A
----
F
L
T
D
R
-
E
V
R
L
---
G
-------
R
N
G
VEE-----
I
R
Q
H
P
F
F
KN
D
--
Q
W
H
W
D
--
N
I
--
R
E
T
--
A
A
P
V
V
P
E
L
S
S
D
I
D
S
S
N
F
D
D
I
E
D
D
--
V
E
T
F
-
P
I
---
P
--
K
A
F
V
G
N
Q
L
P
F
I
G
F
T
Y
Y
R
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
35
PsiBlast_CBE
93.15
43%
-60
- C3 -
2ETK
1
ROCK1_HUMAN
B:
[23-399]
------------------------------------------------------
S
E
V
N
S
D
C
L
L
D
G
L
D
A
L
V
Y
D
L
D
F
P
A
L
R
K
N
K
N
I
D
N
F
L
S
R
Y
K
D
T
I
N
K
I
R
D
L
R
M
K
A
E
--
D
Y
E
V
V
K
V
I
G
R
G
A
F
G
E
V
Q
L
V
R
H
K
---
S
T
R
K
V
Y
A
M
K
L
L
S
K
F
E
M
I
K
R
-
S
D
S
A
F
F
W
E
E
R
D
I
M
A
F
A
-
N
S
-
P
W
V
V
Q
L
F
Y
A
F
Q
D
D
R
Y
L
Y
M
V
M
E
Y
M
P
G
G
D
L
V
N
L
M
S
N
Y
D
--
V
P
E
K
W
A
R
F
Y
T
A
E
V
V
L
A
L
D
A
I
H
S
-
M
G
F
I
H
R
D
V
K
P
D
N
M
L
L
D
K
S
G
H
L
K
L
A
D
F
G
T
C
M
K
M
N
K
E
G
M
V
R
C
D
T
A
V
G
T
P
D
Y
I
S
P
E
V
L
K
S
Q
G
G
D
--
G
Y
Y
G
R
E
C
D
W
W
S
V
G
V
F
L
Y
E
M
L
V
G
D
T
P
F
Y
A
D
S
L
V
G
T
Y
S
K
I
M
----
N
H
K
N
S
L
T
F
P
-----
D
--
D
-
N
D
I
S
K
E
A
K
--
N
L
I
C
A
----
F
L
T
D
R
-
E
V
R
L
---
G
-------
R
N
G
V
E
E
-----
I
K
R
H
L
F
F
--
K
ND
Q
W
A
W
E
--
T
L
--
R
D
T
--
V
A
P
V
V
P
D
L
S
S
D
I
D
T
S
N
F
D
D
L
E
E
D
K
G
E
E
E
T
F
P
I
---
P
--
K
A
F
V
G
N
Q
L
P
F
V
G
F
T
Y
Y
S
N
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
36
PsiBlast_CBE
93.14
43%
-61
- C3 -
2ESM
1
ROCK1_HUMAN
B:
[23-399]
------------------------------------------------------
S
E
V
N
S
D
C
L
L
D
G
L
D
A
L
V
Y
D
L
D
F
P
A
L
R
K
N
K
N
I
D
N
F
L
S
R
Y
K
D
T
I
N
K
I
R
D
L
R
M
K
A
E
--
D
Y
E
V
V
K
V
I
G
R
G
A
F
G
E
V
Q
L
V
R
H
K
---
S
T
R
K
V
Y
A
M
K
L
L
S
K
F
E
M
I
K
R
-
S
D
S
A
F
F
W
E
E
R
D
I
M
A
F
A
-
N
S
-
P
W
V
V
Q
L
F
Y
A
F
Q
D
D
R
Y
L
Y
M
V
M
E
Y
M
P
G
G
D
L
V
N
L
M
S
N
Y
D
--
V
P
E
K
W
A
R
F
Y
T
A
E
V
V
L
A
L
D
A
I
H
S
-
M
G
F
I
H
R
D
V
K
P
D
N
M
L
L
D
K
S
G
H
L
K
L
A
D
F
G
T
C
M
K
M
N
K
E
G
M
V
R
C
D
T
A
V
G
T
P
D
Y
I
S
P
E
V
L
K
S
Q
G
G
D
--
G
Y
Y
G
R
E
C
D
W
W
S
V
G
V
F
L
Y
E
M
L
V
G
D
T
P
F
Y
A
D
S
L
V
G
T
Y
S
K
I
M
----
N
H
K
N
S
L
T
F
P
-----
D
--
D
-
N
D
I
S
K
E
A
K
--
N
L
I
C
A
----
F
L
T
D
R
-
E
V
R
L
---
G
-------
R
N
G
V
E
E
-----
I
K
R
H
L
F
F
--
K
ND
Q
W
A
W
E
--
T
L
--
R
D
T
--
V
A
P
V
V
P
D
L
S
S
D
I
D
T
S
N
F
D
D
L
E
E
D
K
G
E
E
E
T
F
P
I
---
P
--
K
A
F
V
G
N
Q
L
P
F
V
G
F
T
Y
Y
S
N
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
34
PsiBlast_CBE
93.05
43%
-61
- C3 -
2ETR
1
ROCK1_HUMAN
B:
[23-399]
------------------------------------------------------
S
E
V
N
S
D
C
L
L
D
G
L
D
A
L
V
Y
D
L
D
F
P
A
L
R
K
N
K
N
I
D
N
F
L
S
R
Y
K
D
T
I
N
K
I
R
D
L
R
M
K
A
E
--
D
Y
E
V
V
K
V
I
G
R
G
A
F
G
E
V
Q
L
V
R
H
K
---
S
T
R
K
V
Y
A
M
K
L
L
S
K
F
E
M
I
K
R
-
S
D
S
A
F
F
W
E
E
R
D
I
M
A
F
A
-
N
S
-
P
W
V
V
Q
L
F
Y
A
F
Q
D
D
R
Y
L
Y
M
V
M
E
Y
M
P
G
G
D
L
V
N
L
M
S
N
Y
D
--
V
P
E
K
W
A
R
F
Y
T
A
E
V
V
L
A
L
D
A
I
H
S
-
M
G
F
I
H
R
D
V
K
P
D
N
M
L
L
D
K
S
G
H
L
K
L
A
D
F
G
T
C
M
K
M
N
K
E
G
M
V
R
C
D
T
A
V
G
T
P
D
Y
I
S
P
E
V
L
K
S
Q
G
G
D
--
G
Y
Y
G
R
E
C
D
W
W
S
V
G
V
F
L
Y
E
M
L
V
G
D
T
P
F
Y
A
D
S
L
V
G
T
Y
S
K
I
M
----
N
H
K
N
S
L
T
F
P
-----
D
--
D
-
N
D
I
S
K
E
A
K
--
N
L
I
C
A
----
F
L
T
D
R
-
E
V
R
L
---
G
-------
R
N
G
V
E
E
-----
I
K
R
H
L
F
F
--
K
ND
Q
W
A
W
E
--
T
L
--
R
D
T
--
V
A
P
V
V
P
D
L
S
S
D
I
D
T
S
N
F
D
D
L
E
E
D
K
G
E
E
E
T
F
P
I
---
P
--
K
A
F
V
G
N
Q
L
P
F
V
G
F
T
Y
Y
S
N
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
PsiBlast_CBE
92.91
43%
-62
- C3 -
5BML
1
ROCK1_HUMAN
B:
[23-399]
------------------------------------------------------
S
E
V
N
S
D
C
L
L
D
G
L
D
A
L
V
Y
D
L
D
F
P
A
L
R
K
N
K
N
I
D
N
F
L
S
R
Y
K
D
T
I
N
K
I
R
D
L
R
M
K
A
E
--
D
Y
E
V
V
K
V
I
G
R
G
A
F
G
E
V
Q
L
V
R
H
K
---
S
T
R
K
V
Y
A
M
K
L
L
S
K
F
E
M
I
K
R
-
S
D
S
A
F
F
W
E
E
R
D
I
M
A
F
A
-
N
S
-
P
W
V
V
Q
L
F
Y
A
F
Q
D
D
R
Y
L
Y
M
V
M
E
Y
M
P
G
G
D
L
V
N
L
M
S
N
Y
D
--
V
P
E
K
W
A
R
F
Y
T
A
E
V
V
L
A
L
D
A
I
H
S
-
M
G
F
I
H
R
D
V
K
P
D
N
M
L
L
D
K
S
G
H
L
K
L
A
D
F
G
T
C
M
K
M
N
K
E
G
M
V
R
C
D
T
A
V
G
T
P
D
Y
I
S
P
E
V
L
K
S
Q
G
G
D
--
G
Y
Y
G
R
E
C
D
W
W
S
V
G
V
F
L
Y
E
M
L
V
G
D
T
P
F
Y
A
D
S
L
V
G
T
Y
S
K
I
M
----
N
H
K
N
S
L
T
F
P
-----
D
--
D
-
N
D
I
S
K
E
A
K
--
N
L
I
C
A
----
F
L
T
D
R
-
E
V
R
L
---
G
-------
R
N
G
V
E
E
-----
I
K
R
H
L
F
F
--
K
ND
Q
W
A
W
E
--
T
L
--
R
D
T
--
V
A
P
V
V
P
D
L
S
S
D
I
D
T
S
N
F
D
D
L
E
E
---
E
E
E
T
F
P
I
---
P
--
K
A
F
V
G
N
Q
L
P
F
V
G
F
T
Y
Y
S
N
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
PsiBlast_CBE
92.89
43%
-63
- C3 -
4YVE
1
ROCK1_HUMAN
B:
[23-399]
------------------------------------------------------
S
E
V
N
S
D
C
L
L
D
G
L
D
A
L
V
Y
D
L
D
F
P
A
L
R
K
N
K
N
I
D
N
F
L
S
R
Y
K
D
T
I
N
K
I
R
D
L
R
M
K
A
E
--
D
Y
E
V
V
K
V
I
G
R
G
A
F
G
E
V
Q
L
V
R
H
K
---
S
T
R
K
V
Y
A
M
K
L
L
S
K
F
E
M
I
K
R
-
S
D
S
A
F
F
W
E
E
R
D
I
M
A
F
A
-
N
S
-
P
W
V
V
Q
L
F
Y
A
F
Q
D
D
R
Y
L
Y
M
V
M
E
Y
M
P
G
G
D
L
V
N
L
M
S
N
Y
D
--
V
P
E
K
W
A
R
F
Y
T
A
E
V
V
L
A
L
D
A
I
H
S
-
M
G
F
I
H
R
D
V
K
P
D
N
M
L
L
D
K
S
G
H
L
K
L
A
D
F
G
T
C
M
K
M
N
K
E
G
M
V
R
C
D
T
A
V
G
T
P
D
Y
I
S
P
E
V
L
K
S
Q
G
G
D
--
G
Y
Y
G
R
E
C
D
W
W
S
V
G
V
F
L
Y
E
M
L
V
G
D
T
P
F
Y
A
D
S
L
V
G
T
Y
S
K
I
M
----
N
H
K
N
S
L
T
F
P
-----
D
--
D
-
N
D
I
S
K
E
A
K
--
N
L
I
C
A
----
F
L
T
D
R
-
E
V
R
L
---
G
-------
R
N
G
V
E
E
-----
I
K
R
H
L
F
F
--
K
ND
Q
W
A
W
E
--
T
L
--
R
D
T
--
V
A
P
V
V
P
D
L
S
S
D
I
D
T
S
N
F
D
D
L
-----
E
E
E
T
F
P
I
---
P
--
K
A
F
V
G
N
Q
L
P
F
V
G
F
T
Y
Y
S
N
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
92.85
43%
-62
- C3 -
4YVE
1
ROCK1_HUMAN
A:
[23-399]
------------------------------------------------------
S
E
V
N
S
D
C
L
L
D
G
L
D
A
L
V
Y
D
L
D
F
P
A
L
R
K
N
K
N
I
D
N
F
L
S
R
Y
K
D
T
I
N
K
I
R
D
L
R
M
K
A
E
--
D
Y
E
V
V
K
V
I
G
R
G
A
F
G
E
V
Q
L
V
R
H
K
---
S
T
R
K
V
Y
A
M
K
L
L
S
K
F
E
M
I
K
R
-
S
D
S
A
F
F
W
E
E
R
D
I
M
A
F
A
-
N
S
-
P
W
V
V
Q
L
F
Y
A
F
Q
D
D
R
Y
L
Y
M
V
M
E
Y
M
P
G
G
D
L
V
N
L
M
S
N
Y
D
--
V
P
E
K
W
A
R
F
Y
T
A
E
V
V
L
A
L
D
A
I
H
S
-
M
G
F
I
H
R
D
V
K
P
D
N
M
L
L
D
K
S
G
H
L
K
L
A
D
F
G
T
C
M
K
M
N
K
E
G
M
V
R
C
D
T
A
V
G
T
P
D
Y
I
S
P
E
V
L
K
S
------
G
Y
Y
G
R
E
C
D
W
W
S
V
G
V
F
L
Y
E
M
L
V
G
D
T
P
F
Y
A
D
S
L
V
G
T
Y
S
K
I
M
----
N
H
K
N
S
L
T
F
P
-----
D
--
D
-
N
D
I
S
K
E
A
K
--
N
L
I
C
A
----
F
L
T
D
R
-
E
V
R
L
---
G
-------
R
N
G
V
E
E
-----
I
K
R
H
L
F
F
--
K
ND
Q
W
A
W
E
--
T
L
--
R
D
T
--
V
A
P
V
V
P
D
L
S
S
D
I
D
T
S
N
F
D
D
L
------
E
E
T
F
P
I
---
P
--
K
A
F
V
G
N
Q
L
P
F
V
G
F
T
Y
Y
S
N
R
R
Y
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
33
PsiBlast_CBE
92.71
43%
-61
- C3 -
3D9V
1
ROCK1_HUMAN
B:
[23-399]
------------------------------------------------------
S
E
V
N
S
D
C
L
L
D
G
L
D
A
L
V
Y
D
L
D
F
P
A
L
R
K
N
K
N
I
D
N
F
L
S
R
Y
K
D
T
I
N
K
I
R
D
L
R
M
K
A
E
--
D
Y
E
V
V
K
V
I
G
R
G
A
F
G
E
V
Q
L
V
R
H
K
---
S
T
R
K
V
Y
A
M
K
L
L
S
K
F
E
M
I
K
R
-
S
D
S
A
F
F
W
E
E
R
D
I
M
A
F
A
-
N
S
-
P
W
V
V
Q
L
F
Y
A
F
Q
D
D
R
Y
L
Y
M
V
M
E
Y
M
P
G
G
D
L
V
N
L
M
S
N
Y
D
--
V
P
E
K
W
A
R
F
Y
T
A
E
V
V
L
A
L
D
A
I
H
S
-
M
G
F
I
H
R
D
V
K
P
D
N
M
L
L
D
K
S
G
H
L
K
L
A
D
F
G
T
C
M
K
M
N
K
E
G
M
V
R
C
D
T
A
V
G
T
P
D
Y
I
S
P
E
V
L
K
S
Q
G
G
D
--
G
Y
Y
G
R
E
C
D
W
W
S
V
G
V
F
L
Y
E
M
L
V
G
D
T
P
F
Y
A
D
S
L
V
G
T
Y
S
K
I
M
----
N
H
K
N
S
L
T
F
P
-----
D
--
D
-
N
D
I
S
K
E
A
K
--
N
L
I
C
A
----
F
L
T
D
R
-
E
V
R
L
---
G
-------
R
N
G
V
E
E
-----
I
K
R
H
L
F
F
--
K
ND
Q
W
A
W
E
--
T
L
--
R
D
T
--
V
A
P
V
V
P
D
L
S
S
D
I
D
T
S
N
F
D
D
L
E
E
D
K
G
E
E
E
T
F
P
I
---
P
--
K
A
F
V
G
N
Q
L
P
F
V
G
F
T
Y
Y
S
N
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
50
PsiBlast_CBE
92.57
43%
-63
- C3 -
4L6Q
1
ROCK2_HUMAN
A:
[24-402]
------------------------------------------------------
S
P
I
N
V
E
S
L
L
D
G
L
N
S
L
V
L
D
L
D
F
P
A
L
R
K
N
K
N
I
D
N
F
L
N
R
Y
E
K
I
V
K
K
I
R
G
L
Q
M
K
A
E
--
D
Y
D
V
V
K
V
I
G
R
G
A
F
G
E
V
Q
L
V
R
H
K
---
A
S
Q
K
V
Y
A
M
K
L
L
S
K
F
E
M
I
K
R
-
S
D
S
A
F
F
W
E
E
R
D
I
M
A
F
A
-
N
S
-
P
W
V
V
Q
L
F
Y
A
F
Q
D
D
R
Y
L
Y
M
V
M
E
Y
M
P
G
G
D
L
V
N
L
M
S
N
Y
D
--
V
P
E
K
W
A
K
F
Y
T
A
E
V
V
L
A
L
D
A
I
H
S
-
M
G
L
I
H
R
D
V
K
P
D
N
M
L
L
D
K
H
G
H
L
K
L
A
D
F
G
T
C
M
K
M
D
E
T
G
M
V
H
C
D
T
A
V
G
T
P
D
Y
I
S
P
E
V
L
K
S
Q
G
G
D
--
G
F
Y
G
R
E
C
D
W
W
S
V
G
V
F
L
Y
E
M
L
V
G
D
T
P
F
Y
A
D
S
L
V
G
T
Y
S
K
I
M
----
D
H
K
N
S
L
C
F
P
-----
E
--
D
-
A
E
I
S
K
H
A
K
--
N
L
I
C
A
----
F
L
T
D
R
-
E
V
R
L
---
G
-------
R
N
G
V
E
E
-----
I
R
Q
H
P
F
F
KN
D
--
Q
W
H
W
D
--
N
I
--
R
E
T
--
A
A
P
V
V
P
E
L
S
S
D
I
D
S
S
N
F
D
D
I
E
D
D
--
V
E
T
F
-
P
I
---
P
--
K
A
F
V
G
N
Q
L
P
F
I
G
F
T
Y
Y
R
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
92.33
43%
-60
- C3 -
3D9V
1
ROCK1_HUMAN
A:
[23-399]
------------------------------------------------------
S
E
V
N
S
D
C
L
L
D
G
L
D
A
L
V
Y
D
L
D
F
P
A
L
R
K
N
K
N
I
D
N
F
L
S
R
Y
K
D
T
I
N
K
I
R
D
L
R
M
K
A
E
--
D
Y
E
V
V
K
V
I
G
R
G
A
F
G
E
V
Q
L
V
R
H
K
---
S
T
R
K
V
Y
A
M
K
L
L
S
K
F
E
M
I
K
R
-
S
D
S
A
F
F
W
E
E
R
D
I
M
A
F
A
-
N
S
-
P
W
V
V
Q
L
F
Y
A
F
Q
D
D
R
Y
L
Y
M
V
M
E
Y
M
P
G
G
D
L
V
N
L
M
S
N
Y
D
--
V
P
E
K
W
A
R
F
Y
T
A
E
V
V
L
A
L
D
A
I
H
S
-
M
G
F
I
H
R
D
V
K
P
D
N
M
L
L
D
K
S
G
H
L
K
L
A
D
F
G
T
C
M
K
M
N
K
E
G
M
V
R
C
D
T
A
V
G
T
P
D
Y
I
S
P
E
V
L
K
S
Q
G
G
D
--
G
Y
Y
G
R
E
C
D
W
W
S
V
G
V
F
L
Y
E
M
L
V
G
D
T
P
F
Y
A
D
S
L
V
G
T
Y
S
K
I
M
----
N
H
K
N
S
L
T
F
P
-----
D
--
D
-
N
D
I
S
K
E
A
K
--
N
L
I
C
A
----
F
L
T
D
R
-
E
V
R
L
---
G
-------
R
N
G
V
E
E
-----
I
K
R
H
L
F
F
--
K
ND
Q
W
A
W
E
--
T
L
--
R
D
T
--
V
A
P
V
V
P
D
L
S
S
D
I
D
T
S
N
F
D
D
L
E
E
D
K
G
E
E
E
T
F
P
I
---
P
--
K
A
F
V
G
N
Q
L
P
F
V
G
F
T
Y
Y
S
N
R
R
Y
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
91.96
43%
-60
- C3 -
5BML
1
ROCK1_HUMAN
A:
[23-399]
------------------------------------------------------
S
E
V
N
S
D
C
L
L
D
G
L
D
A
L
V
Y
D
L
D
F
P
A
L
R
K
N
K
N
I
D
N
F
L
S
R
Y
K
D
T
I
N
K
I
R
D
L
R
M
K
A
E
--
D
Y
E
V
V
K
V
I
G
R
G
A
F
G
E
V
Q
L
V
R
H
K
---
S
T
R
K
V
Y
A
M
K
L
L
S
K
F
E
M
I
K
R
-
S
D
S
A
F
F
W
E
E
R
D
I
M
A
F
A
-
N
S
-
P
W
V
V
Q
L
F
Y
A
F
Q
D
D
R
Y
L
Y
M
V
M
E
Y
M
P
G
G
D
L
V
N
L
M
S
N
Y
D
--
V
P
E
K
W
A
R
F
Y
T
A
E
V
V
L
A
L
D
A
I
H
S
-
M
G
F
I
H
R
D
V
K
P
D
N
M
L
L
D
K
S
G
H
L
K
L
A
D
F
G
T
C
M
K
M
N
K
E
G
M
V
R
C
D
T
A
V
G
T
P
D
Y
I
S
P
E
V
L
K
S
Q
G
G
D
--
G
Y
Y
G
R
E
C
D
W
W
S
V
G
V
F
L
Y
E
M
L
V
G
D
T
P
F
Y
A
D
S
L
V
G
T
Y
S
K
I
M
----
N
H
K
N
S
L
T
F
P
-----
D
--
D
---
I
S
K
E
A
K
--
N
L
I
C
A
----
F
L
T
D
R
-
E
V
R
L
---
G
-------
R
N
G
V
E
E
-----
I
K
R
H
L
F
F
--
K
ND
Q
W
A
W
E
--
T
L
--
R
D
T
--
V
A
P
V
V
P
D
L
S
S
D
I
D
T
S
N
F
D
D
L
-----
E
E
E
T
F
P
I
---
P
--
K
A
F
V
G
N
Q
L
P
F
V
G
F
T
Y
Y
S
N
R
R
Y
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
91.08
43%
-60
- C3 -
2ESM
1
ROCK1_HUMAN
A:
[23-399]
------------------------------------------------------
S
E
V
N
S
D
C
L
L
D
G
L
D
A
L
V
Y
D
L
D
F
P
A
L
R
K
N
K
N
I
D
N
F
L
S
R
Y
K
D
T
I
N
K
I
R
D
L
R
M
K
A
E
--
D
Y
E
V
V
K
V
I
G
R
G
A
F
G
E
V
Q
L
V
R
H
K
---
S
T
R
K
V
Y
A
M
K
L
L
S
K
F
E
M
I
K
R
-
S
D
S
A
F
F
W
E
E
R
D
I
M
A
F
A
-
N
S
-
P
W
V
V
Q
L
F
Y
A
F
Q
D
D
R
Y
L
Y
M
V
M
E
Y
M
P
G
G
D
L
V
N
L
M
S
N
Y
D
--
V
P
E
K
W
A
R
F
Y
T
A
E
V
V
L
A
L
D
A
I
H
S
-
M
G
F
I
H
R
D
V
K
P
D
N
M
L
L
D
K
S
G
H
L
K
L
A
D
F
G
T
C
M
K
M
N
K
E
G
M
V
R
C
D
T
A
V
G
T
P
D
Y
I
S
P
E
V
L
K
S
Q
G
G
D
--
G
Y
Y
G
R
E
C
D
W
W
S
V
G
V
F
L
Y
E
M
L
V
G
D
T
P
F
Y
A
D
S
L
V
G
T
Y
S
K
I
M
----
N
H
K
N
S
L
T
F
P
-----
D
--
D
-
N
D
I
S
K
E
A
K
--
N
L
I
C
A
----
F
L
T
D
R
-
E
V
R
L
---
G
-------
R
N
G
V
E
E
-----
I
K
R
H
L
F
F
--
K
ND
Q
W
A
W
E
--
T
L
--
R
D
T
--
V
A
P
V
V
P
D
L
S
S
D
I
D
T
S
N
F
D
D
L
E
E
D
K
G
E
E
E
T
F
P
I
---
P
--
K
A
F
V
G
N
Q
L
P
F
V
G
F
T
Y
Y
S
N
R
R
Y
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
91.01
43%
-59
- C3 -
2V55
1
ROCK1_HUMAN
A:
[23-399]
------------------------------------------------------
S
E
V
N
S
D
C
L
L
D
G
L
D
A
L
V
Y
D
L
D
F
P
A
L
R
K
N
K
N
I
D
N
F
L
S
R
Y
K
D
T
I
N
K
I
R
D
L
R
M
K
A
E
--
D
Y
E
V
V
K
V
I
G
R
G
A
F
G
E
V
Q
L
V
R
H
K
---
S
T
R
K
V
Y
A
M
K
L
L
S
K
F
E
M
I
K
R
-
S
D
S
A
F
F
W
E
E
R
D
I
M
A
F
A
-
N
S
-
P
W
V
V
Q
L
F
Y
A
F
Q
D
D
R
Y
L
Y
M
V
M
E
Y
M
P
G
G
D
L
V
N
L
M
S
N
Y
D
--
V
P
E
K
W
A
R
F
Y
T
A
E
V
V
L
A
L
D
A
I
H
S
-
M
G
F
I
H
R
D
V
K
P
D
N
M
L
L
D
K
S
G
H
L
K
L
A
D
F
G
T
C
M
K
M
N
K
E
G
M
V
R
C
D
T
A
V
G
T
P
D
Y
I
S
P
E
V
L
K
S
Q
G
G
D
--
G
Y
Y
G
R
E
C
D
W
W
S
V
G
V
F
L
Y
E
M
L
V
G
D
T
P
F
Y
A
D
S
L
V
G
T
Y
S
K
I
M
----
N
H
K
N
S
L
T
F
P
-----
D
--
D
-
N
D
I
S
K
E
A
K
--
N
L
I
C
A
----
F
L
T
D
R
-
E
V
R
L
---
G
-------
R
N
G
V
E
E
-----
I
K
R
H
L
F
F
--
K
ND
Q
W
A
W
E
--
T
L
--
R
D
T
--
V
A
P
V
V
P
D
L
S
S
D
I
D
T
S
N
F
D
D
L
------
E
E
T
F
P
I
---
P
--
K
A
F
V
G
N
Q
L
P
F
V
G
F
T
Y
Y
S
N
R
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
90.89
43%
-62
- C3 -
2ETK
1
ROCK1_HUMAN
A:
[23-399]
------------------------------------------------------
S
E
V
N
S
D
C
L
L
D
G
L
D
A
L
V
Y
D
L
D
F
P
A
L
R
K
N
K
N
I
D
N
F
L
S
R
Y
K
D
T
I
N
K
I
R
D
L
R
M
K
A
E
--
D
Y
E
V
V
K
V
I
G
R
G
A
F
G
E
V
Q
L
V
R
H
K
---
S
T
R
K
V
Y
A
M
K
L
L
S
K
F
E
M
I
K
R
-
S
D
S
A
F
F
W
E
E
R
D
I
M
A
F
A
-
N
S
-
P
W
V
V
Q
L
F
Y
A
F
Q
D
D
R
Y
L
Y
M
V
M
E
Y
M
P
G
G
D
L
V
N
L
M
S
N
Y
D
--
V
P
E
K
W
A
R
F
Y
T
A
E
V
V
L
A
L
D
A
I
H
S
-
M
G
F
I
H
R
D
V
K
P
D
N
M
L
L
D
K
S
G
H
L
K
L
A
D
F
G
T
C
M
K
M
N
K
E
G
M
V
R
C
D
T
A
V
G
T
P
D
Y
I
S
P
E
V
L
K
S
Q
G
G
D
--
G
Y
Y
G
R
E
C
D
W
W
S
V
G
V
F
L
Y
E
M
L
V
G
D
T
P
F
Y
A
D
S
L
V
G
T
Y
S
K
I
M
----
N
H
K
N
S
L
T
F
P
-----
D
--
D
-
N
D
I
S
K
E
A
K
--
N
L
I
C
A
----
F
L
T
D
R
-
E
V
R
L
---
G
-------
R
N
G
V
E
E
-----
I
K
R
H
L
F
F
--
K
ND
Q
W
A
W
E
--
T
L
--
R
D
T
--
V
A
P
V
V
P
D
L
S
S
D
I
D
T
S
N
F
D
D
L
E
E
D
K
G
E
E
E
T
F
P
I
---
P
--
K
A
F
V
G
N
Q
L
P
F
V
G
F
T
Y
Y
S
N
R
R
Y
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
90.84
43%
-63
- C3 -
2ETR
1
ROCK1_HUMAN
A:
[23-399]
------------------------------------------------------
S
E
V
N
S
D
C
L
L
D
G
L
D
A
L
V
Y
D
L
D
F
P
A
L
R
K
N
K
N
I
D
N
F
L
S
R
Y
K
D
T
I
N
K
I
R
D
L
R
M
K
A
E
--
D
Y
E
V
V
K
V
I
G
R
G
A
F
G
E
V
Q
L
V
R
H
K
---
S
T
R
K
V
Y
A
M
K
L
L
S
K
F
E
M
I
K
R
-
S
D
S
A
F
F
W
E
E
R
D
I
M
A
F
A
-
N
S
-
P
W
V
V
Q
L
F
Y
A
F
Q
D
D
R
Y
L
Y
M
V
M
E
Y
M
P
G
G
D
L
V
N
L
M
S
N
Y
D
--
V
P
E
K
W
A
R
F
Y
T
A
E
V
V
L
A
L
D
A
I
H
S
-
M
G
F
I
H
R
D
V
K
P
D
N
M
L
L
D
K
S
G
H
L
K
L
A
D
F
G
T
C
M
K
M
N
K
E
G
M
V
R
C
D
T
A
V
G
T
P
D
Y
I
S
P
E
V
L
K
S
Q
G
G
D
--
G
Y
Y
G
R
E
C
D
W
W
S
V
G
V
F
L
Y
E
M
L
V
G
D
T
P
F
Y
A
D
S
L
V
G
T
Y
S
K
I
M
----
N
H
K
N
S
L
T
F
P
-----
D
--
D
-
N
D
I
S
K
E
A
K
--
N
L
I
C
A
----
F
L
T
D
R
-
E
V
R
L
---
G
-------
R
N
G
V
E
E
-----
I
K
R
H
L
F
F
--
K
ND
Q
W
A
W
E
--
T
L
--
R
D
T
--
V
A
P
V
V
P
D
L
S
S
D
I
D
T
S
N
F
D
D
L
E
E
D
K
G
E
E
E
T
F
P
I
---
P
--
K
A
F
V
G
N
Q
L
P
F
V
G
F
T
Y
Y
S
N
R
R
Y
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
52
PsiBlast_CBE
90.50
42%
-63
- C3 -
2F2U
1
ROCK2_BOVIN
B:
[24-402]
------------------------------------------------------
S
P
I
N
V
E
S
L
L
D
G
L
N
S
L
V
L
D
L
D
F
P
A
L
R
K
N
K
N
I
D
N
F
L
N
R
Y
E
K
I
V
K
K
I
R
G
L
Q
M
K
A
E
--
D
Y
D
V
V
K
V
I
G
R
G
A
F
G
E
V
Q
L
V
R
H
K
---
A
S
Q
K
V
Y
A
M
K
L
L
S
K
F
E
M
I
K
R
-
S
D
S
A
F
F
W
E
E
R
D
I
M
A
F
A
-
N
S
-
P
W
V
V
Q
L
F
C
A
F
Q
D
D
K
Y
L
Y
M
V
M
E
Y
M
P
G
G
D
L
V
N
L
M
S
N
Y
D
--
V
P
E
K
W
A
K
F
Y
T
A
E
V
V
L
A
L
D
A
I
H
S
-
M
G
L
I
H
R
D
V
K
P
D
N
M
L
L
D
K
H
G
H
L
K
L
A
D
F
G
T
C
M
K
M
D
E
T
G
M
V
H
C
D
T
A
V
G
T
P
D
Y
I
S
P
E
V
L
K
S
Q
G
G
D
--
G
Y
Y
G
R
E
C
D
W
W
S
V
G
V
F
L
F
E
M
L
V
G
D
T
P
F
Y
A
D
S
L
V
G
T
Y
S
K
I
M
----
D
H
K
N
S
L
C
F
P
-----
E
--
D
-
A
E
I
S
K
H
A
K
--
N
L
I
C
A
----
F
L
T
D
R
-
E
V
R
L
---
G
-------
R
N
G
VEE-----
I
K
Q
H
P
F
F
KN
D
--
Q
W
N
W
D
--
N
I
--
R
E
T
--
A
A
P
V
V
P
E
L
S
S
D
I
D
S
S
N
F
D
D
I
-------
T
F
-
P
I
---
P
--
K
A
F
V
G
N
Q
L
P
F
I
G
F
T
Y
Y
R
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
53
PsiBlast_CBE
90.40
42%
-63
- C3 -
2F2U
1
ROCK2_BOVIN
A:
[24-402]
------------------------------------------------------
S
P
I
N
V
E
S
L
L
D
G
L
N
S
L
V
L
D
L
D
F
P
A
L
R
K
N
K
N
I
D
N
F
L
N
R
Y
E
K
I
V
K
K
I
R
G
L
Q
M
K
A
E
--
D
Y
D
V
V
K
V
I
G
R
G
A
F
G
E
V
Q
L
V
R
H
K
---
A
S
Q
K
V
Y
A
M
K
L
L
S
K
F
E
M
I
K
R
-
S
D
S
A
F
F
W
E
E
R
D
I
M
A
F
A
-
N
S
-
P
W
V
V
Q
L
F
C
A
F
Q
D
D
K
Y
L
Y
M
V
M
E
Y
M
P
G
G
D
L
V
N
L
M
S
N
Y
D
--
V
P
E
K
W
A
K
F
Y
T
A
E
V
V
L
A
L
D
A
I
H
S
-
M
G
L
I
H
R
D
V
K
P
D
N
M
L
L
D
K
H
G
H
L
K
L
A
D
F
G
T
C
M
K
M
D
E
T
G
M
V
H
C
D
T
A
V
G
T
P
D
Y
I
S
P
E
V
L
K
S
Q
G
G
D
--
G
Y
Y
G
R
E
C
D
W
W
S
V
G
V
F
L
F
E
M
L
V
G
D
T
P
F
Y
A
D
S
L
V
G
T
Y
S
K
I
M
----
D
H
K
N
S
L
C
F
P
-----
E
--
D
-
A
E
I
S
K
H
A
K
--
N
L
I
C
A
----
F
L
T
D
R
-
E
V
R
L
---
G
-------
R
N
G
V
E
E
-----
I
K
Q
H
P
F
F
KN
D
--
Q
W
N
W
D
--
N
I
--
R
E
T
--
A
A
P
V
V
P
E
L
S
S
D
I
D
S
S
N
F
D
D
I
E
----
V
E
T
F
-
P
I
---
P
--
K
A
F
V
G
N
Q
L
P
F
I
G
F
T
Y
Y
R
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
51
PsiBlast_CBE
89.29
42%
-57
- C3 -
2H9V
1
ROCK2_BOVIN
A:
[24-402]
------------------------------------------------------
S
P
I
N
V
E
S
L
L
D
G
L
N
S
L
V
L
D
L
D
F
P
A
L
R
K
N
K
N
I
D
N
F
L
N
R
Y
E
K
I
V
K
K
I
R
G
L
Q
M
K
A
E
--
D
Y
D
V
V
K
V
I
G
R
G
A
F
G
E
V
Q
L
V
R
H
K
---
A
S
Q
K
V
Y
A
M
K
L
L
S
K
F
E
M
I
K
R
-
S
D
S
A
F
F
W
E
E
R
D
I
M
A
F
A
-
N
S
-
P
W
V
V
Q
L
F
C
A
F
Q
D
D
K
Y
L
Y
M
V
M
E
Y
M
P
G
G
D
L
V
N
L
M
S
N
Y
D
--
V
P
E
K
W
A
K
F
Y
T
A
E
V
V
L
A
L
D
A
I
H
S
-
M
G
L
I
H
R
D
V
K
P
D
N
M
L
L
D
K
H
G
H
L
K
L
A
D
F
G
T
C
M
K
M
D
E
T
G
M
V
H
C
D
T
A
V
G
T
P
D
Y
I
S
P
E
V
L
K
S
Q
G
G
D
--
G
Y
Y
G
R
E
C
D
W
W
S
V
G
V
F
L
F
E
M
L
V
G
D
T
P
F
Y
A
D
S
L
V
G
T
Y
S
K
I
M
----
D
H
K
N
S
L
C
F
P
-----
E
--
D
-
A
E
I
S
K
H
A
K
--
N
L
I
C
A
----
F
L
T
D
R
-
E
V
R
L
---
G
-------
R
N
G
V
E
E
-----
I
K
Q
H
P
F
F
KN
D
--
Q
W
N
W
D
--
N
I
--
R
E
T
--
A
A
P
V
V
P
E
L
S
S
D
I
D
S
S
N
F
D
D
I
E
----------
I
---
P
--
K
A
F
V
G
N
Q
L
P
F
I
G
F
T
Y
Y
R
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
73
PsiBlast_CBE
77.66
34%
-48
- C3 -
4L43
1
KS6B1_HUMAN
A:
[20-342]
-------------------------------------------------------------------------------------------------------------
F
E
L
L
R
V
L
G
K
G
G
Y
G
K
V
F
Q
V
R
K
V
TGA
N
T
G
K
I
F
A
M
K
V
L
K
K
A
M
I
V
R
N
A
K
D
T
A
H
T
K
A
E
R
N
I
L
E
E
V
-
K
H
-
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
-
E
G
I
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
-
K
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
H
Q
G
H
V
K
L
T
D
F
G
L
C
K
E
S
------------
G
T
I
E
Y
M
A
P
E
I
L
M
------
R
S
G
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
P
P
F
T
G
E
N
R
K
K
T
I
D
K
I
L
----
K
C
K
L
N
L
-----------
P
-
P
Y
L
T
Q
E
A
R
--
D
L
L
K
K
----
L
L
K
R
N
A
A
S
R
L
---
G
AGPGD--
A
G
E
--------
V
Q
A
H
P
F
F
--
R
--
H
I
N
W
E
--
E
L
L
A
R
K
V
--
E
P
P
F
K
P
L
L
Q
S
E
E
D
V
S
Q
F
D
S
K
F
T
R
Q
T
P
V
-------------
S
A
N
Q
V
--
F
L
G
F
A
Y
V
A
P
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
68
PsiBlast_CBE
76.82
34%
-43
- C3 -
2UZT
1
KAPCA_BOVIN
A:
[29-317]
-------------------------------------------------------------------------------------------------------------
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
---
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
Q
A
V
-
N
F
-
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
V
K
G
R
T
W
T
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
-----
S
K
G
-
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
I
Y
E
K
I
V
----
S
G
K
--
V
R
F
P
-----
S
-----
H
F
S
S
D
L
K
--
D
L
L
R
N
----
L
L
--
Q
-
V
D
L
T
---
K
-------
R
F
G
NLKDG
V
N
D
I
K
N
H
K
W
F
--
A
--
T
T
D
W
I
--
A
I
Y
Q
R
K
V
--
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
I
R
V
S
I
-
N
E
K
C
G
K
--
E
F
S
E
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
64
PsiBlast_CBE
76.63
34%
-39
- C3 -
2F7E
1
KAPCA_BOVIN
E:
[44-332]
-------------------------------------------------------------------------------------------------------------
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
---
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
Q
A
V
-
N
F
-
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
V
K
G
R
T
W
T
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
-----
S
K
G
-
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
I
Y
E
K
I
V
----
S
G
K
--
V
R
F
P
-----
S
-----
H
F
S
S
D
L
K
--
D
L
L
R
N
----
L
L
--
Q
-
V
D
L
T
---
K
-------
R
F
G
NLKNGVND
I
K
N
H
K
W
F
--
A
--
T
T
D
W
I
--
A
I
YQ
R
K
V
--
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
I
R
V
S
I
-
N
E
K
C
G
K
--
E
F
S
E
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
72
PsiBlast_CBE
76.03
34%
-40
- C3 -
4L44
1
KS6B1_HUMAN
A:
[20-342]
-------------------------------------------------------------------------------------------------------------
F
E
L
L
R
V
L
G
K
G
G
Y
G
K
V
F
Q
V
R
K
V
TGA
N
T
G
K
I
F
A
M
K
V
L
K
K
A
M
I
V
R
N
A
K
D
T
A
H
T
K
A
E
R
N
I
L
E
E
V
-
K
H
-
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
-
E
G
I
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
-
K
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
H
Q
G
H
V
K
L
T
D
F
G
L
C
K
E
S
I
H
------
H
T
F
C
G
T
I
E
Y
M
A
P
E
I
L
M
------
R
S
G
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
P
P
F
T
G
E
N
R
K
K
T
I
D
K
I
L
----
K
C
K
L
N
L
-----------
P
-
P
Y
L
T
Q
E
A
R
--
D
L
L
K
K
----
L
L
K
R
N
A
A
S
R
L
---
G
AGPGD--
A
G
E
--------
V
Q
A
H
P
F
F
--
R
--
H
I
N
W
E
--
E
L
L
A
R
K
V
--
E
P
P
F
K
P
L
L
Q
S
E
E
D
V
S
Q
-
D
S
K
F
T
R
Q
T
-------------
S
E
S
A
N
Q
V
--
F
L
G
F
A
Y
V
A
P
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
63
PsiBlast_CBE
75.95
34%
-38
- C3 -
2F7X
1
KAPCA_BOVIN
E:
[44-332]
-------------------------------------------------------------------------------------------------------------
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
---
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
Q
A
V
-
N
F
-
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
V
K
G
R
T
W
T
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
-----
S
K
G
-
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
I
Y
E
K
I
V
----
S
G
K
--
V
R
F
P
-----
S
-----
H
F
S
S
D
L
K
--
D
L
L
R
N
----
L
L
--
Q
-
V
D
L
T
---
K
-------
R
F
G
NLKNGVND
I
K
N
H
K
W
F
--
A
--
T
T
D
W
I
--
A
I
YQ
R
K
V
--
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
I
R
V
S
I
-
N
E
K
C
G
K
--
E
F
S
E
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
60
PsiBlast_CBE
75.81
34%
-39
- C3 -
2OJF
1
KAPCA_BOVIN
E:
[44-332]
-------------------------------------------------------------------------------------------------------------
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
---
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
Q
A
V
-
N
F
-
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
V
K
G
R
T
W
T
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
-----
S
K
G
-
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
I
Y
E
K
I
V
----
S
G
K
--
V
R
F
P
-----
S
-----
H
F
S
S
D
L
K
--
D
L
L
R
N
----
L
L
--
Q
-
V
D
L
T
---
K
-------
R
F
G
NLKNGVND
I
K
N
H
K
W
F
--
A
--
T
T
D
W
I
--
A
I
YQ
R
K
V
--
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
I
R
V
S
I
-
N
E
K
C
G
K
--
E
F
S
E
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
65
PsiBlast_CBE
75.16
34%
-40
- C3 -
2UZW
1
KAPCA_BOVIN
E:
[29-317]
-------------------------------------------------------------------------------------------------------------
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
---
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
Q
A
V
-
N
F
-
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
V
K
G
R
T
W
T
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
-----
S
K
G
-
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
I
Y
E
K
I
V
----
S
G
K
--
V
R
F
P
-----
S
-----
H
F
S
S
D
L
K
--
D
L
L
R
N
----
L
L
--
Q
-
V
D
L
T
---
K
-------
R
F
G
NLKDGVND
I
K
N
H
K
W
F
--
A
--
T
T
D
W
I
--
A
I
YQ
R
K
V
--
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
I
R
V
S
I
-
N
E
K
C
G
K
--
E
F
S
E
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
61
PsiBlast_CBE
75.12
34%
-41
- C3 -
2OH0
1
KAPCA_BOVIN
E:
[44-332]
-------------------------------------------------------------------------------------------------------------
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
---
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
Q
A
V
-
N
F
-
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
V
K
G
R
T
W
T
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
-----
S
K
G
-
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
I
Y
E
K
I
V
----
S
G
K
--
V
R
F
P
-----
S
-----
H
F
S
S
D
L
K
--
D
L
L
R
N
----
L
L
--
Q
-
V
D
L
T
---
K
-------
R
F
G
NLKNGVND
I
K
N
H
K
W
F
--
A
--
T
T
D
W
I
--
A
I
YQ
R
K
V
--
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
I
R
V
S
I
-
N
E
K
C
G
K
--
E
F
S
E
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
67
PsiBlast_CBE
74.49
34%
-39
- C3 -
2UZU
1
KAPCA_BOVIN
E:
[29-317]
-------------------------------------------------------------------------------------------------------------
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
---
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
Q
A
V
-
N
F
-
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
V
K
G
R
T
W
T
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
-----
S
K
G
-
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
I
Y
E
K
I
V
----
S
G
K
--
V
R
F
P
-----
S
-----
H
F
S
S
D
L
K
--
D
L
L
R
N
----
L
L
--
Q
-
V
D
L
T
---
K
-------
R
F
G
NLKDGVND
I
K
N
H
K
W
F
--
A
--
T
T
D
W
I
--
A
I
YQ
R
K
V
--
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
I
R
V
S
I
-
N
E
K
C
G
K
--
E
F
S
E
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
62
PsiBlast_CBE
74.14
34%
-44
- C3 -
2F7Z
1
KAPCA_BOVIN
E:
[44-332]
-------------------------------------------------------------------------------------------------------------
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
---
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
Q
A
V
-
N
F
-
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
V
K
G
R
T
W
T
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
-----
S
K
G
-
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
I
Y
E
K
I
V
----
S
G
K
--
V
R
F
P
-----
S
-----
H
F
S
S
D
L
K
--
D
L
L
R
N
----
L
L
--
Q
-
V
D
L
T
---
K
-------
R
F
G
NLKNGVND
I
K
N
H
K
W
F
--
A
--
T
T
D
W
I
--
A
I
YQ
R
K
V
--
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
I
R
V
S
I
-
N
E
K
C
G
K
--
E
F
S
E
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
70
PsiBlast_CBE
73.72
36%
-38
- C3 -
4EJN
3
AKT1_HUMAN
A:
[146-438]
-------------------------------------------------------------------------------------------------------
T
M
N
--
E
F
E
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
K
E
K
---
A
T
G
R
Y
Y
A
M
K
I
L
K
K
E
V
I
V
--------------
V
L
Q
N
S
-
R
H
-
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
-
E
R
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
K
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
K
D
G
H
I
K
I
T
D
F
G
-
L
C
K
E
G
I
K
-----
K
T
F
C
G
T
P
E
Y
L
A
P
E
V
L
E
------
D
N
D
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
Y
N
Q
D
H
E
K
L
F
E
L
I
L
M
E
E
I
R
F
P
R
T
L
G
-
P
-----
E
--
A
-
K
S
L
L
S
G
L
L
KK
D
P
K
Q
R
----
L
G
G
G
S
-
E
D
A
-------------
K
E
--------
I
M
Q
H
R
F
F
--
A
--
G
I
V
W
Q
--
H
V
Y
E
K
K
L
--
S
P
P
F
K
P
Q
V
T
S
E
T
D
T
R
Y
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
66
PsiBlast_CBE
72.86
34%
-35
- C3 -
2UZV
1
KAPCA_BOVIN
A:
[29-317]
-------------------------------------------------------------------------------------------------------------
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
---
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
Q
A
V
-
N
F
-
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
V
K
G
R
T
W
T
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
-----
S
K
G
-
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
I
Y
E
K
I
V
----
S
G
K
--
V
R
F
P
-----
S
-----
H
F
S
S
D
L
K
--
D
L
L
R
N
----
L
L
--
Q
-
V
D
L
T
---
K
-------
R
F
G
NLKDG
V
N
D
I
K
N
H
K
W
F
--
A
--
T
T
D
W
I
--
A
I
Y
Q
R
K
V
--
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
I
R
V
S
I
-
N
E
K
C
G
K
--
E
F
S
E
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
79
PsiBlast_CBE
71.32
34%
-43
- C3 -
3WF8
2
KS6B1_HUMAN
A:
[21-302]
-------------------------------------------------------------------------------------------------------------
F
E
L
L
R
V
L
G
K
G
G
Y
G
K
V
F
Q
V
R
K
V
TGA
N
T
G
K
I
F
A
M
K
V
L
K
K
A
M
I
V
R
N
A
K
D
T
A
H
T
K
A
E
R
N
I
L
E
E
V
-
K
H
-
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
-
E
G
I
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
-
K
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
H
Q
G
H
V
K
L
T
D
F
G
L
C
K
E
S
I
H
D
G
T
V
T
H
T
-
F
C
G
T
I
E
Y
M
A
P
E
I
L
M
------
R
S
G
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
P
P
F
T
G
E
N
R
K
K
T
I
D
K
I
L
----
K
C
K
L
N
L
-----------
P
-
P
Y
L
T
Q
E
A
R
--
D
L
L
K
K
----
L
L
K
R
N
A
A
S
R
L
---
G
AGP
G
D
--
A
G
E
--------
V
Q
A
H
P
F
F
--
R
--
H
I
N
W
E
--
E
L
L
A
R
K
V
--
E
P
P
F
K
P
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
59
PsiBlast_CBE
71.30
36%
-30
- C3 -
3TXO
1
A:
[24-315]
------------------------------------------------------------------------------------------------------------
N
F
E
F
I
R
V
L
G
K
G
S
F
G
K
V
M
L
A
R
V
K
---
E
T
G
D
L
Y
A
V
K
V
L
K
K
D
V
I
L
Q
D
-
D
D
V
E
C
T
M
T
E
K
R
I
L
S
L
A
R
N
H
-
P
F
L
T
Q
L
F
C
C
F
Q
T
P
D
R
L
F
F
V
M
E
F
V
N
G
G
D
L
M
F
H
I
Q
K
S
R
-
R
F
D
E
A
R
A
R
F
Y
A
A
E
I
I
S
A
L
M
F
L
H
D
-
K
G
I
I
Y
R
D
L
K
L
D
N
V
L
L
D
H
E
G
H
C
K
L
A
D
F
G
M
C
K
E
G
I
C
----------
G
T
P
D
Y
I
A
P
E
I
L
Q
E
M
------
L
Y
G
P
A
V
D
W
W
A
M
G
V
L
L
Y
E
M
L
C
G
H
A
P
F
E
A
E
N
E
D
D
L
F
E
A
I
L
----
N
D
E
--
V
V
Y
P
TWLH
E
D
--
A
-
T
G
I
L
K
S
F
M
--
T
K
N
P
T
----
M
R
L
G
S
-
L
T
Q
G
---
G
-------
E
H
A
--------
I
L
R
H
P
F
F
--
K
--
E
I
D
W
A
Q
L
N
H
--
R
Q
I
--
E
P
P
F
R
P
R
I
K
S
R
E
D
V
S
N
F
D
P
D
F
I
K
E
E
P
V
L
T
-
P
I
D
E
G
H
--
L
P
M
I
N
Q
D
E
F
R
N
F
E
Y
V
S
P
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
78
PsiBlast_CBE
71.24
34%
-45
- C3 -
3WF9
2
KS6B1_HUMAN
A:
[21-302]
-------------------------------------------------------------------------------------------------------------
F
E
L
L
R
V
L
G
K
G
G
Y
G
K
V
F
Q
V
R
K
V
TGA
N
T
G
K
I
F
A
M
K
V
L
K
K
A
M
I
V
R
N
A
K
D
T
A
H
T
K
A
E
R
N
I
L
E
E
V
-
K
H
-
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
-
E
G
I
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
-
K
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
H
Q
G
H
V
K
L
T
D
F
G
L
C
K
E
S
I
H
D
G
T
V
T
H
T
-
F
C
G
T
I
E
Y
M
A
P
E
I
L
M
------
R
S
G
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
P
P
F
T
G
E
N
R
K
K
T
I
D
K
I
L
----
K
C
K
L
N
L
-----------
P
-
P
Y
L
T
Q
E
A
R
--
D
L
L
K
K
----
L
L
K
R
N
A
A
S
R
L
---
G
AGP
G
D
--
A
G
E
--------
V
Q
A
H
P
F
F
--
R
--
H
I
N
W
E
--
E
L
L
A
R
K
V
--
E
P
P
F
K
P
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
81
PsiBlast_CBE
71.21
34%
-41
- C3 -
3WF5
1
KS6B1_HUMAN
A:
[21-304]
-------------------------------------------------------------------------------------------------------------
F
E
L
L
R
V
L
G
K
G
G
Y
G
K
V
F
Q
V
R
K
V
TGA
N
T
G
K
I
F
A
M
K
V
L
K
K
------------
T
K
A
E
R
N
I
L
E
E
V
-
K
H
-
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
-
E
G
I
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
-
K
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
H
Q
G
H
V
K
L
T
D
F
G
L
C
K
E
S
I
H
D
G
T
V
T
H
T
-
F
C
G
T
I
E
Y
M
A
P
E
I
L
M
------
R
S
G
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
P
P
F
T
G
E
N
R
K
K
T
I
D
K
I
L
----
K
C
K
L
N
L
-----------
P
-
P
Y
L
T
Q
E
A
R
--
D
L
L
K
K
----
L
L
K
R
N
A
A
S
R
L
---
G
AGP
G
D
--
A
G
E
--------
V
Q
A
H
P
F
F
--
R
--
H
I
N
W
E
--
E
L
L
A
R
K
V
--
E
P
P
F
K
P
L
L
Q
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
80
PsiBlast_CBE
70.92
34%
-44
- C3 -
3WF6
1
KS6B1_HUMAN
A:
[21-304]
-------------------------------------------------------------------------------------------------------------
F
E
L
L
R
V
L
G
K
G
G
Y
G
K
V
F
Q
V
R
K
V
TGA
N
T
G
K
I
F
A
M
K
V
L
K
K
------------
T
K
A
E
R
N
I
L
E
E
V
-
K
H
-
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
-
E
G
I
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
-
K
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
H
Q
G
H
V
K
L
T
D
F
G
L
C
K
E
S
I
H
D
G
T
V
T
H
T
-
F
C
G
T
I
E
Y
M
A
P
E
I
L
M
------
R
S
G
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
P
P
F
T
G
E
N
R
K
K
T
I
D
K
I
L
----
K
C
K
L
N
L
-----------
P
-
P
Y
L
T
Q
E
A
R
--
D
L
L
K
K
----
L
L
K
R
N
A
A
S
R
L
---
G
AGP
G
D
--
A
G
E
--------
V
Q
A
H
P
F
F
--
R
--
H
I
N
W
E
--
E
L
L
A
R
K
V
--
E
P
P
F
K
P
L
L
Q
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
74
PsiBlast_CBE
70.72
34%
-53
- C3 -
4L42
1
KS6B1_HUMAN
A:
[20-342]
-------------------------------------------------------------------------------------------------------------
F
E
L
L
R
V
L
G
K
G
G
Y
G
K
V
F
Q
V
R
K
V
TGA
N
T
G
K
I
F
A
M
K
V
L
K
K
A
M
I
V
R
N
A
K
D
T
A
H
T
K
A
E
R
N
I
L
E
E
V
-
K
H
-
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
-
E
G
I
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
-
K
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
H
Q
G
H
V
K
L
T
D
F
G
L
C
K
E
S
I
H
D
G
T
V
-
T
H
T
F
C
G
T
I
E
Y
M
A
P
E
I
L
M
------
R
S
G
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
P
P
F
T
G
E
N
R
K
K
T
I
D
K
I
L
----
K
C
K
L
N
L
-----------
P
-
P
Y
L
T
Q
E
A
R
--
D
L
L
K
K
----
L
L
K
R
N
A
A
S
R
L
---
G
AGPG
D
--
A
G
E
--------
V
Q
A
H
P
F
F
--
R
--
H
I
N
W
E
--
E
L
L
A
R
K
V
--
E
P
P
F
K
----------------------------------------
E
M
F
R
D
F
E
Y
I
A
D
W
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
58
PsiBlast_CBE
69.80
35%
-45
- C3 -
2R5T
1
SGK1_HUMAN
A:
[32-320]
-----------------------------------------------------------------------------------------------------
N
P
H
A
K
PS
D
F
H
F
L
K
V
I
G
K
G
S
F
G
K
V
L
L
A
R
H
K
---
A
E
E
V
F
Y
A
V
K
V
L
Q
K
K
A
I
L
--------------
V
L
L
K
N
-
V
K
H
P
F
L
V
G
L
H
F
S
F
Q
T
A
D
K
L
Y
F
V
L
D
Y
I
N
G
G
E
L
F
Y
H
L
Q
R
-
E
R
C
F
L
E
P
R
A
R
F
Y
A
A
E
I
A
S
A
L
G
Y
L
H
S
-
L
N
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
S
Q
G
H
I
V
L
T
D
F
G
-
L
C
K
E
N
I
E
H
N
S
T
T
S
T
F
C
G
T
P
E
Y
L
A
P
E
V
L
H
------
K
Q
P
Y
D
R
T
V
D
W
W
C
L
G
A
V
L
Y
E
M
L
Y
G
L
P
P
F
Y
S
R
N
T
A
E
M
Y
D
N
I
L
----
N
K
P
L
Q
L
K
------------
P
N
I
T
N
S
A
R
--
H
L
L
E
G
----
L
L
--
Q
-
K
D
R
T
---
K
RLGAKDD
F
M
E
--------
I
K
S
H
V
F
F
--
S
--
L
I
N
W
D
--
D
L
--
I
N
K
KI
T
P
P
F
N
P
N
V
S
G
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
57
PsiBlast_CBE
69.31
35%
-44
- C3 -
3HDM
1
SGK1_HUMAN
A:
[32-320]
-----------------------------------------------------------------------------------------------------
N
P
H
A
K
PS
D
F
H
F
L
K
V
I
G
K
G
S
F
G
K
V
L
L
A
R
H
K
---
A
E
E
V
F
Y
A
V
K
V
L
Q
K
K
A
I
L
--------------
V
L
L
K
N
-
V
K
H
P
F
L
V
G
L
H
F
S
F
Q
T
A
D
K
L
Y
F
V
L
D
Y
I
N
G
G
E
L
F
Y
H
L
Q
R
-
E
R
C
F
L
E
P
R
A
R
F
Y
A
A
E
I
A
S
A
L
G
Y
L
H
S
-
L
N
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
S
Q
G
H
I
V
L
T
D
F
G
-
L
C
K
E
N
I
E
H
N
S
T
T
S
T
F
C
G
T
P
E
Y
L
A
P
E
V
L
H
------
K
Q
P
Y
D
R
T
V
D
W
W
C
L
G
A
V
L
Y
E
M
L
Y
G
L
P
P
F
Y
S
R
N
T
A
E
M
Y
D
N
I
L
----
N
K
P
L
Q
L
K
------------
P
N
I
T
N
S
A
R
--
H
L
L
E
G
----
L
L
--
Q
-
K
D
R
T
---
K
RLGAKDD
F
M
E
--------
I
K
S
H
V
F
F
--
S
--
L
I
N
W
D
--
D
L
--
I
N
K
KI
T
P
P
F
N
P
N
V
S
G
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
69
PsiBlast_CBE
68.66
36%
-54
- C3 -
3O96
1
AKT1_HUMAN
A:
[149-432]
-------------------------------------------------------------------------------------------------------
T
M
N
--
E
F
E
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
K
E
K
---
A
T
G
R
Y
Y
A
M
K
I
L
K
K
E
V
I
V
A
-----------
N
R
V
L
Q
N
S
-
R
H
-
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
-
E
R
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
K
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
K
D
G
H
I
K
I
T
D
F
G
-
L
C
K
E
--------------
P
E
Y
L
A
P
E
V
L
E
------
D
N
D
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
Y
N
Q
D
H
E
K
L
F
E
L
I
L
----
M
E
E
--
I
R
F
P
-----
R
TL
G
-
P
E
A
K
S
L
L
S
--
G
L
L
K
K
DPKQ
R
L
G
G
G
-
S
E
D
A
---
K
---------
E
--------
I
M
Q
H
R
F
F
--
A
--
G
I
V
W
Q
--
H
V
Y
E
K
K
L
--
S
P
P
F
K
P
Q
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
56
PsiBlast_CBE
68.45
35%
-44
- C3 -
3HDN
1
SGK1_HUMAN
A:
[32-316]
-----------------------------------------------------------------------------------------------------
N
P
H
A
K
PS
D
F
H
F
L
K
V
I
G
K
G
S
F
G
K
V
L
L
A
R
H
K
---
A
E
E
V
F
Y
A
V
K
V
L
Q
K
K
A
I
L
--------------
V
L
L
K
N
-
V
K
H
P
F
L
V
G
L
H
F
S
F
Q
T
A
D
K
L
Y
F
V
L
D
Y
I
N
G
G
E
L
F
Y
H
L
Q
R
-
E
R
C
F
L
E
P
R
A
R
F
Y
A
A
E
I
A
S
A
L
G
Y
L
H
S
-
L
N
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
S
Q
G
H
I
V
L
T
D
F
G
-
L
C
K
E
N
I
E
H
N
S
T
T
S
T
F
C
G
T
P
E
Y
L
A
P
E
V
L
H
------
K
Q
P
Y
D
R
T
V
D
W
W
C
L
G
A
V
L
Y
E
M
L
Y
G
L
P
P
F
Y
S
R
N
T
A
E
M
Y
D
N
I
L
----
N
K
P
L
Q
L
K
------------
P
N
I
T
N
S
A
R
--
H
L
L
E
G
----
L
L
--
Q
-
K
D
R
T
---
K
RLGAKDD
F
M
E
--------
I
K
S
H
V
F
F
--
S
--
L
I
N
W
D
--
D
L
--
I
N
K
KI
T
P
P
F
N
P
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
75
PsiBlast_CBE
67.98
34%
-50
* C3 *
3A61
1
KS6B1_HUMAN
A:
[19-299]
-------------------------------------------------------------------------------------------------------------
F
E
L
L
R
V
L
G
K
G
G
Y
G
K
V
F
Q
V
R
K
V
T
GA
N
T
G
K
I
F
A
M
K
V
L
K
---------------
A
E
R
N
I
L
E
E
V
-
K
H
-
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
-
E
G
I
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
-
K
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
H
Q
G
H
V
K
L
T
D
F
G
-----------------
G
T
I
E
Y
M
A
P
E
I
L
M
------
R
S
G
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
P
P
F
T
G
E
N
R
K
K
T
I
D
K
I
L
----
K
C
K
L
N
L
-----------
P
-
P
Y
L
T
Q
E
A
R
--
D
L
L
K
K
----
L
L
K
R
N
A
A
S
R
L
---
G
AGPG
D
--
A
G
E
--------
V
Q
A
H
P
F
F
--
R
--
H
I
N
W
E
--
E
L
L
A
R
K
V
--
E
P
P
F
K
P
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
77
PsiBlast_CBE
65.69
34%
-38
- C3 -
3A60
1
KS6B1_HUMAN
A:
[19-299]
-------------------------------------------------------------------------------------------------------------
F
E
L
L
R
V
L
G
K
G
G
Y
G
K
V
F
Q
V
R
K
V
T
GA
N
T
G
K
I
F
A
M
K
V
L
K
K
A
M
-----------
K
A
E
R
N
I
L
E
E
V
-
K
H
-
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
-
E
G
I
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
-
K
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
H
Q
G
H
V
K
L
T
D
F
G
L
C
K
E
--------------
T
I
E
Y
M
A
P
E
I
L
M
------
R
S
G
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
P
P
F
T
G
E
N
R
K
K
T
I
D
K
I
L
----
K
C
K
L
N
L
-----------
P
-
P
Y
L
T
Q
E
A
R
--
D
L
L
K
K
----
L
L
K
R
N
A
A
S
R
L
---
G
AGPG
D
--
A
G
E
--------
V
Q
A
H
P
F
F
--
R
--
H
I
N
W
E
--
E
L
L
A
R
K
V
--
E
P
P
F
K
P
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
76
PsiBlast_CBE
61.87
34%
-43
- C3 -
3A60
1
KS6B1_HUMAN
B:
[19-300]
-------------------------------------------------------------------------------------------------------------
F
E
L
L
R
V
L
G
K
G
G
Y
G
K
V
F
Q
V
R
K
V
TGA
N
T
G
K
I
F
A
M
K
V
L
K
K
------------------------
K
H
-
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
-
E
G
I
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
-
K
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
H
Q
G
H
V
K
L
T
D
F
G
L
C
K
E
S
-----------
C
G
T
I
E
Y
M
A
P
E
I
L
M
------
R
S
G
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
P
P
F
T
G
E
N
R
K
K
T
I
D
K
I
L
----
K
C
K
L
N
L
-----------
P
-
P
Y
L
T
Q
E
A
R
--
D
L
L
K
K
----
L
L
K
R
N
A
A
S
R
L
---
G
AGPG
D
--
A
G
E
--------
V
Q
A
H
P
F
F
--
R
--
H
I
N
W
E
--
E
L
L
A
R
K
V
--
E
P
P
F
K
P
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------