@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : DAPK1_HUMAN: (2015-10-06 )
MTVFRQENVDDYYDTGEELGSGQFAVVKKCREKSTGLQYAAKFIKKRRTKSSRRGVSREDIEREVSILKEIQHPNVITLHEVYENKTDVILILELVAGGELFDFLAEKESLTEEEATEFLKQILNGVYYLHSLQIAHFDLKPENIMLLDRNVPKPRIKIIDFGLAHKIDFGNEFKNIFGTPEFVAPEIVNYEPLGLEADMWSIGVITYILLSGASPFLGDTKQETLANVSAVNYEFEDEYFSNTSALAKDFIRRLLVKDPKKRMTIQDSLQHPWIKPKDTQQALSRKASAVNMEKFKKFAARKKWKQSVRLISLCQRLSRSFLSRSNMSVARSDDTLDEEDSFVMKAIIHAINDDNVPGLQHLLGSLSNYDVNQPNKHGTPPLLIAAGCGNIQILQLLIKRGSRIDVQDKGGSNAVYWAARHGHVDTLKFLSENKCPLDVKDKSGEMALHVAARYGHADVAQLLCSFGSNPNIQDKEEETPLHCAAWHGYYSVAKALCEAGCNVNIKNREGETPLLTASARGYHDIVECLAEHGADLNACDKDGHIALHLAVRRCQMEVIKTLLSQGCFVDYQDRHGNTPLHVACKDGNMPIVVALCEANCNLDISNKYGRTPLHLAANNGILDVVRYLCLMGASVEALTTDGKTAEDLARSEQHEHVAGLLARLRKDTHRGLFIQQLRPTQNLQPRIKLKLFGHSGSGKTTLVESLKCGLLRSFFRRRRPRLSSTNSSRFPPSPLASKPTVSVSINNLYPGCENVSVRSRSMMFEPGLTKGMLEVFVAPTHHPHCSADDQSTKAIDIQNAYLNGVGDFSVWEFSGNPVYFCCYDYFAANDPTSIHVVVFSLEEPYEIQLNQVIFWLSFLKSLVPVEEPIAFGGKLKNPLQVVLVATHADIMNVPRPAGGEFGYDKDTSLLKEIRNRFGNDLHISNKLFVLDAGASGSKDMKVLRNHLQEIRSQIVSVCPPMTHLCEKIISTLPSWRKLNGPNQLMSLQQFVYDVQDQLNPLASEEDLRRIAQQLHSTGEINIMQSETVQDVLLLDPRWLCTNVLGKLLSVETPRALHHYRGRYTVEDIQRLVPDSDVEELLQILDAMDICARDLSSGTMVDVPALIKTDNLHRSWADEEDEVMVYGGVRIVPVEHLTPFPCGIFHKVQVNLCRWIHQQSTEGDADIRLWVNGCKLANRGAELLVLLVNHGQGIEVQVRGLETEKIKCCLLLDSVCSTIENVMATTLPGLLTVKHYLSPQQLREHHEPVMIYQPRDFFRAQTLKETSLTNTMGGYKESFSSIMCFGCHDVYSQASLGMDIHASDLNLLTRRKLSRLLDPPDPLGKDWCLLAMNLGLPDLVAKYNTSNGAPKDFLPSPLHALLREWTTYPESTVGTLMSKLRELGRRDAADFLLKASSVFKINLDGNGQEAYASSCNSGTSYNSISSVVSR
Atome Classification :
(54 SA)
.........10...-..--...20........30........40........50........60........70..-......80........90........100..-.-...-..110-.........120.......130.......140.....--..150.......160......-.170.-......180.......190.......200.......210.......220........230.......240.......250.......260.......270.......280.......290.----.----.....300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770.......780.......790.......800.......810.......820.......830.......840.......850.......860.......870.......880.......890.......900.......910.......920.......930.......940.......950.......960.......970.......980.......990.......1000......1010......1020......1030......1040......1050......1060......1070......1080......1090......1100......1110......1120......1130......1140......1150......1160......1170......1180......1190......1200......1210......1220......1230......1240......1250......1260......1270......1280......1290......1300......1310......1320......1330......1340......1350......1360......1370......1380......1390......1400......1410......1420......1430
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MT
V
F
RQENV
D
D
Y
YD-
T
G
--
E
ELGS
G
Q
F
A
V
V
K
K
C
R
EKST
G
L
Q
Y
A
A
K
F
I
K
K
RRTKSSRRGV
S
R
E
D
I
E
R
E
V
S
I
L
K
E
IQH-P
N
V
I
T
L
H
E
V
YENKT
D
V
I
L
I
L
E
LVAG
G
E
L
-
F
D
-
F
-
L
A
E
-
K
ES---L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
DLKPE
N
I
M
L
--
L
DRNVPKP
R
I
K
I
I
DFGL
A
H
KI-DF
G
N
E
-
F
K
N
IFGTPEFVAPEIVNYEPLGLEA
D
M
W
S
I
G
V
I
T
Y
I
L
LSGASPFLGD
T
-
K
Q
E
T
LAN
V
S
A
V
N
Y
E
F
E
D
E
YFS
N
T
S
A
L
A
K
D
F
I
R
R
L
L
VKDPKKR
M
T
I
Q
D
SLQHPWIKP
K
D
T
Q
Q
A
L
S
R
K
ASAV
N
M
----
E
----
K
F
K
K
F
A
A
R
K
K
W
K
Q
S
V
R
L
I
S
L
C
Q
R
L
S
R
S
F
L
SRSNMSVARSDDTLDE
E
D
S
F
V
M
K
A
I
I
H
A
INDDNV
P
G
L
Q
H
L
L
G
S
LSNYDVNQPNKHGTP
P
L
L
I
A
AGCG
N
I
Q
I
L
Q
L
L
I
KRG
S
R
I
D
V
QDKGGSN
A
V
Y
W
A
ARHGH
V
D
T
L
K
F
L
SENKCPLDVKDKSG
E
M
A
L
H
V
A
A
RYG
H
A
D
V
A
Q
L
L
C
SFGSNPNIQDKEEETP
L
H
C
A
A
W
H
G
Y
Y
S
V
A
K
A
L
C
EAGCN
V
N
I
KNREGET
P
L
L
T
ASAR
G
Y
H
D
I
V
E
C
L
A
EHGADLNACDKDG
H
I
A
L
H
L
A
V
R
R
C
Q
M
E
V
I
K
T
L
L
SQG
C
F
V
D
Y
QDRHGNT
P
L
H
V
A
CKDGNM
P
I
V
V
A
L
CEANCN
L
D
ISNKYGRT
P
L
H
L
AANN
G
I
L
D
V
V
R
Y
L
C
LMGAS
V
E
A
L
TTDGK
T
A
E
D
L
A
R
S
E
Q
H
E
H
V
A
G
L
L
A
R
L
R
K
DTHR
G
L
F
I
Q
QLRPTQNLQ
P
R
I
K
L
K
L
F
G
HSGSG
K
T
T
L
V
E
S
L
K
C
G
L
L
R
S
F
F
R
RRRPRLSSTNSSRFPPSPLASK
P
T
V
S
V
S
INNLYPGCENVSVRSR
S
M
MFEPGL
T
K
G
M
L
E
V
FVAPTHHPHCSADDQS
T
K
A
I
D
I
Q
N
A
Y
LNGVGDF
S
V
W
E
FSG
N
P
V
Y
F
C
C
Y
D
YFAANDP
T
S
I
H
V
V
V
F
SLEE
P
Y
E
I
Q
L
N
Q
V
I
F
W
L
S
F
L
K
S
LVPVEEPIAFGGKLKN
P
L
Q
V
V
L
V
ATH
A
D
IMNVPRPAGGEFGYD
K
D
T
S
L
L
K
E
I
R
N
RFGNDLHIS
N
K
L
F
V
L
DAGASGS
K
D
M
K
V
L
R
N
H
L
Q
E
I
R
S
Q
I
V
S
VCP
P
M
T
H
L
C
E
K
I
I
S
TLP
S
W
RKLNG
P
N
Q
L
M
S
L
Q
Q
F
V
Y
D
V
Q
D
QLNPLA
S
E
E
D
L
R
R
I
A
Q
Q
L
HSTG
E
I
N
I
M
QSETV
Q
D
V
L
LLD
P
R
W
L
C
T
N
V
L
G
K
L
LSVET
P
R
A
L
H
H
YRGRY
T
V
E
D
I
Q
R
LVP
D
S
D
V
E
E
L
L
Q
I
L
D
A
M
D
I
C
A
R
DLSSG
T
M
VDVP
A
L
I
KTDNLHRSWADEED
E
V
M
V
YG
G
V
R
I
V
PVEHLTPFPC
G
I
F
H
K
V
Q
V
N
L
C
R
W
I
H
QQSTEGD
A
D
I
R
L
W
V
NGCKLANRG
A
E
L
L
V
L
L
VNHGQ
G
I
E
V
Q
V
RGLETE
K
I
K
C
C
L
L
L
D
S
V
C
S
T
I
E
N
V
M
A
T
T
L
P
G
L
L
T
V
K
H
YL
S
P
Q
Q
L
R
E
HHE
P
V
M
I
YQP
R
D
F
F
R
A
Q
T
L
K
ETSLTNTMG
G
Y
K
E
S
F
S
S
I
M
CFG
C
H
D
V
Y
S
QASLG
M
D
I
H
A
S
D
L
N
L
L
T
R
R
K
L
S
R
LLDPPDPLG
K
D
W
C
L
L
A
MNLG
L
P
D
L
V
A
KYNTSNGAPKDFL
P
S
P
L
H
A
L
L
R
E
WTTYPE
S
T
V
G
T
L
M
S
K
L
R
E
LGR
R
D
A
A
D
F
L
L
KAS
S
V
F
K
I
N
LDGNG
Q
E
A
Y
ASSCNSGTSY
N
S
I
S
S
V
VSR
15
PsiBlast_PDB
88.92
100%
-75
- C1 -
4TXC
7
DAPK1_HUMAN
A:
[21-296]
-
T
V
F
R
Q
E
N
V
D
D
Y
Y
D
-
T
G
--
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
R
T
K
S
S
R
R
G
V
S
R
E
D
I
E
R
E
V
S
I
L
K
E
I
Q
H
-
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
-
F
D
-
F
-
L
A
E
-
K
E
S
---
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
--
L
D
R
N
V
P
K
P
R
I
K
I
I
D
F
G
L
A
H
K
I
-
D
F
G
N
E
-
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
Y
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
-
K
Q
E
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
P
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
88.88
100%
-73
- C1 -
2Y0A
1
DAPK1_HUMAN
A:
[3-302]
--
V
F
R
Q
E
N
V
D
D
Y
Y
D
-
T
G
--
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
R
T
K
S
S
R
R
G
V
S
R
E
D
I
E
R
E
V
S
I
L
K
E
I
Q
H
-
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
-
F
D
-
F
-
L
A
E
-
K
E
S
---
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
--
L
D
R
N
V
P
K
P
R
I
K
I
I
D
F
G
L
A
H
K
I
-
D
F
G
N
E
-
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
Y
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
-
K
Q
E
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
P
K
D
T
Q
Q
A
L
S
R
K
A
S
A
V
N
M
----
E
----
K
F
K
K
F
A
A
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
88.17
100%
-71
- C1 -
2W4K
1
DAPK1_HUMAN
A:
[2-302]
-
T
V
F
R
Q
E
N
V
D
D
Y
Y
D
-
T
G
--
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
R
T
K
S
S
R
R
G
V
S
R
E
D
I
E
R
E
V
S
I
L
K
E
I
Q
H
-
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
-
F
D
-
F
-
L
A
E
-
K
E
S
---
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
--
L
D
R
N
V
P
K
P
R
I
K
I
I
D
F
G
L
A
H
K
I
-
D
F
G
N
E
-
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
Y
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
-
K
Q
E
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
P
K
D
T
Q
Q
A
L
S
R
K
A
S
A
V
N
M
----
E
----
K
F
K
K
F
A
A
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
87.80
99%
-69
- C1 -
2XUU
1
DAPK1_HUMAN
A:
[2-302]
-
T
V
F
R
Q
E
N
V
D
D
Y
Y
D
-
T
G
--
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
R
T
K
S
S
R
R
G
V
S
R
E
D
I
E
R
E
V
S
I
L
K
E
I
Q
H
-
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
-
F
D
-
F
-
L
A
E
-
K
E
S
---
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
--
L
D
R
N
V
P
K
P
R
I
K
I
I
D
F
G
L
A
H
K
I
-
D
F
G
N
E
-
F
K
N
I
F
G
T
P
A
F
V
A
P
E
I
V
N
Y
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
-
K
Q
E
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
P
K
D
T
Q
Q
A
L
S
R
K
A
S
A
V
N
M
----
E
----
K
F
K
K
F
A
A
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
87.76
99%
-71
- C1 -
4UV0
1
?
A:
[5-304]
--
V
F
R
Q
E
N
V
D
D
Y
Y
D
-
T
G
--
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
R
T
K
S
S
R
R
G
V
S
R
E
D
I
E
R
E
V
S
I
L
K
E
I
Q
H
-
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
-
F
D
-
F
-
L
A
E
-
K
E
S
---
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
--
L
D
R
N
V
P
K
P
R
I
K
I
I
D
F
G
L
A
H
K
I
-
D
F
G
N
E
-
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
Y
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
-
K
Q
E
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
P
K
D
T
Q
Q
A
L
S
R
K
A
C
A
V
N
M
----
E
----
K
F
K
K
F
A
A
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
86.95
100%
-76
- C1 -
2YAK
1
DAPK1_HUMAN
A:
[2-278]
-
T
V
F
R
Q
E
N
V
D
D
Y
Y
D
-
T
G
--
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
R
T
K
S
S
R
R
G
V
S
R
E
D
I
E
R
E
V
S
I
L
K
E
I
Q
H
-
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
-
F
D
-
F
-
L
A
E
-
K
E
S
---
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
--
L
D
R
N
V
P
K
P
R
I
K
I
I
D
F
G
L
A
H
K
I
-
D
F
G
N
E
-
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
Y
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
-
K
Q
E
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
P
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
36
PsiBlast_CBE
86.84
100%
-78
- C1 -
1WVY
1
DAPK1_HUMAN
A:
[4-276]
---
F
R
Q
E
N
V
D
D
Y
Y
D
-
T
G
--
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
R
T
K
S
S
R
R
G
V
S
R
E
D
I
E
R
E
V
S
I
L
K
E
I
Q
H
-
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
-
F
D
-
F
-
L
A
E
-
K
E
S
---
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
--
L
D
R
N
V
P
K
P
R
I
K
I
I
D
F
G
L
A
H
K
I
-
D
F
G
N
E
-
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
Y
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
-
K
Q
E
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
29
PsiBlast_CBE
86.76
97%
-76
- C1 -
3GUB
1
DAPK1_HUMAN
A:
[2-293]
-
T
V
F
R
Q
E
N
V
D
D
Y
Y
D
-
T
G
--
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
R
T
K
S
S
R
R
G
V
S
R
E
D
I
E
R
E
V
S
I
L
K
E
I
Q
H
-
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
G
E
L
V
A
G
G
E
L
-
F
D
-
F
-
L
A
E
-
K
E
S
---
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
--
L
D
R
N
V
P
K
P
R
I
K
I
I
D
F
G
L
A
H
K
I
-
D
F
G
N
E
-
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
Y
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
-
K
Q
E
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
P
--------------
Q
F
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
PsiBlast_CBE
86.44
97%
-73
- C1 -
3EHA
1
DAPK1_HUMAN
A:
[1-293]
-
T
V
F
R
Q
E
N
V
D
D
Y
Y
D
-
T
G
--
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
R
T
K
S
S
R
R
G
V
S
R
E
D
I
E
R
E
V
S
I
L
K
E
I
Q
H
-
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
-
F
D
-
F
-
L
A
E
-
K
-
S
---
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
--
L
D
R
N
V
P
K
P
R
I
K
I
I
D
F
G
L
A
H
K
I
-
D
F
G
N
E
-
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
Y
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
-
K
Q
E
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
P
-------------
P
Q
F
----
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
31
PsiBlast_CBE
86.42
97%
-72
- C1 -
3GU7
1
DAPK1_HUMAN
A:
[2-294]
-
T
V
F
R
Q
E
N
V
D
D
Y
Y
D
-
T
G
--
E
E
L
G
S
G
V
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
R
T
K
S
S
R
R
G
V
S
R
E
D
I
E
R
E
V
S
I
L
K
E
I
Q
H
-
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
-
F
D
-
F
-
L
A
E
-
K
E
S
---
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
--
L
D
R
N
V
P
K
P
R
I
K
I
I
D
F
G
L
A
H
K
I
-
D
F
G
N
E
-
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
Y
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
-
K
Q
E
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
P
-------------
P
Q
F
----
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
86.27
99%
-68
- C1 -
4B4L
3
DAPK1_HUMAN
A:
[7-305]
----
R
Q
E
N
V
D
D
Y
Y
D
-
T
G
--
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
R
T
K
S
S
R
R
G
V
S
R
E
D
I
E
R
E
V
S
I
L
K
E
I
Q
H
-
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
-
F
D
-
F
-
L
A
E
-
K
E
S
---
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
--
L
D
R
N
V
P
K
P
R
I
K
I
I
D
F
G
L
A
H
K
I
-
D
F
G
N
E
-
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
Y
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
-
K
Q
E
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
P
K
D
T
Q
Q
A
L
S
R
K
A
S
A
V
N
M
----
E
----
K
F
K
K
F
A
A
A
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
86.23
97%
-73
- C1 -
1IG1
1
DAPK1_HUMAN
A:
[1-293]
-
T
V
F
R
Q
E
N
V
D
D
Y
Y
D
-
T
G
--
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
R
T
K
S
S
R
R
G
V
S
R
E
D
I
E
R
E
V
S
I
L
K
E
I
Q
H
-
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
-
F
D
-
F
-
L
A
E
-
K
E
S
---
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
--
L
D
R
N
V
P
K
P
R
I
K
I
I
D
F
G
L
A
H
K
I
-
D
F
G
N
E
-
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
Y
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
-
K
Q
E
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
P
-------------
P
Q
F
----
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
85.95
97%
-75
- C1 -
3DFC
1
DAPK1_HUMAN
B:
[2-294]
-
T
V
F
R
Q
E
N
V
D
D
Y
Y
D
-
T
G
--
E
E
L
G
S
G
K
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
R
T
K
S
S
R
R
G
V
S
R
E
D
I
E
R
E
V
S
I
L
K
E
I
Q
H
-
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
-
F
D
-
F
-
L
A
E
-
K
E
S
---
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
--
L
D
R
N
V
P
K
P
R
I
K
I
I
D
F
G
L
A
H
K
I
-
D
F
G
N
E
-
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
Y
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
-
K
Q
E
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
P
-------------
P
Q
F
----
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
85.93
97%
-75
- C1 -
1JKK
1
DAPK1_HUMAN
A:
[1-292]
-
T
V
F
R
Q
E
N
V
D
D
Y
Y
D
-
T
G
--
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
R
T
K
S
S
R
R
G
V
S
R
E
D
I
E
R
E
V
S
I
L
K
E
I
Q
H
-
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
-
F
D
-
F
-
L
A
E
-
K
E
S
---
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
--
L
D
R
N
V
P
K
P
R
I
K
I
I
D
F
G
L
A
H
K
I
-
D
F
G
N
E
-
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
Y
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
-
K
Q
E
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
P
---------------
F
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
PsiBlast_CBE
85.74
97%
-71
- C1 -
4YPD
1
DAPK1_HUMAN
A:
[1-294]
-
T
V
F
R
Q
E
N
V
D
D
Y
Y
D
-
T
G
--
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
R
T
K
S
S
R
R
G
V
S
R
E
D
I
E
R
E
V
S
I
L
K
E
I
Q
H
-
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
-
F
D
-
F
-
L
A
E
-
K
E
S
---
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
--
L
D
R
N
V
P
K
P
R
I
K
I
I
D
F
G
L
A
H
K
I
-
D
F
G
N
E
-
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
Y
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
-
K
Q
E
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
P
-------------
P
Q
F
----
E
----
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
30
PsiBlast_CBE
85.72
97%
-75
- C1 -
3GU8
1
DAPK1_HUMAN
A:
[2-293]
-
T
V
F
R
Q
E
N
V
D
D
Y
Y
D
-
T
G
--
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
R
T
K
S
S
R
R
G
V
S
R
E
D
I
E
R
E
V
S
I
L
K
E
I
Q
H
-
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
G
E
L
V
A
G
G
E
L
-
F
D
-
F
-
L
A
E
-
K
E
S
---
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
--
L
D
R
N
V
P
K
P
R
I
K
I
I
D
F
G
L
A
H
K
I
-
D
F
G
N
E
-
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
Y
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
-
K
Q
E
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
P
--------------
Q
F
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
PsiBlast_CBE
85.61
97%
-71
- C1 -
4YO4
1
DAPK1_HUMAN
A:
[1-294]
-
T
V
F
R
Q
E
N
V
D
D
Y
Y
D
-
T
G
--
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
R
T
K
S
S
R
R
G
V
S
R
E
D
I
E
R
E
V
S
I
L
K
E
I
Q
H
-
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
-
F
D
-
F
-
L
A
E
-
K
E
S
---
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
--
L
D
R
N
V
P
K
P
R
I
K
I
I
D
F
G
L
A
H
K
I
-
D
F
G
N
E
-
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
Y
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
-
K
Q
E
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
P
--------------
Q
F
----
E
----
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
85.46
97%
-73
- C1 -
1JKL
1
DAPK1_HUMAN
A:
[1-293]
-
T
V
F
R
Q
E
N
V
D
D
Y
Y
D
-
T
G
--
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
R
T
K
S
S
R
R
G
V
S
R
E
D
I
E
R
E
V
S
I
L
K
E
I
Q
H
-
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
-
F
D
-
F
-
L
A
E
-
K
E
S
---
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
--
L
D
R
N
V
P
K
P
R
I
K
I
I
D
F
G
L
A
H
K
I
-
D
F
G
N
E
-
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
Y
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
-
K
Q
E
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
P
-------------
P
Q
F
----
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
32
PsiBlast_CBE
85.22
97%
-73
- C1 -
3GU6
1
DAPK1_HUMAN
A:
[2-294]
-
T
V
F
R
Q
E
N
V
D
D
Y
Y
D
-
T
G
--
E
E
L
G
S
G
V
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
R
T
K
S
S
R
R
G
V
S
R
E
D
I
E
R
E
V
S
I
L
K
E
I
Q
H
-
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
-
F
D
-
F
-
L
A
E
-
K
E
S
---
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
--
L
D
R
N
V
P
K
P
R
I
K
I
I
D
F
G
L
A
H
K
I
-
D
F
G
N
E
-
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
Y
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
-
K
Q
E
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
P
-------------
P
Q
F
----
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
34
PsiBlast_CBE
85.16
97%
-72
- C1 -
3GU4
1
DAPK1_HUMAN
A:
[2-294]
-
T
V
F
R
Q
E
N
V
D
D
Y
Y
D
-
T
G
--
E
E
L
G
S
G
V
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
R
T
K
S
S
R
R
G
V
S
R
E
D
I
E
R
E
V
S
I
L
K
E
I
Q
H
-
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
-
F
D
-
F
-
L
A
E
-
K
E
S
---
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
--
L
D
R
N
V
P
K
P
R
I
K
I
I
D
F
G
L
A
H
K
I
-
D
F
G
N
E
-
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
Y
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
-
K
Q
E
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
P
-------------
P
Q
F
----
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
85.06
97%
-69
- C1 -
3F5U
1
DAPK1_HUMAN
A:
[2-294]
-
T
V
F
R
Q
E
N
V
D
D
Y
Y
D
-
T
G
--
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
R
T
K
S
S
R
R
G
V
S
R
E
D
I
E
R
E
V
S
I
L
K
E
I
Q
H
-
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
-
F
D
-
F
-
L
A
E
-
K
E
S
---
L
T
E
E
E
A
T
E
F
-
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
--
L
D
R
N
V
P
K
P
R
I
K
I
I
D
F
G
L
A
H
K
I
-
D
F
G
N
E
-
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
Y
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
-
K
Q
E
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
P
-------------
P
Q
F
----
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
38
PsiBlast_CBE
85.00
100%
-74
- C1 -
2W4J
1
DAPK1_HUMAN
A:
[2-277]
-
T
V
F
R
Q
E
N
V
D
D
Y
Y
D
-
T
G
--
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
R
T
K
S
S
R
R
G
V
S
R
E
D
I
E
R
E
V
S
I
L
K
E
I
Q
H
-
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
-
F
D
-
F
-
L
A
E
-
K
E
S
---
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
--
L
D
R
N
V
P
K
P
R
I
K
I
I
D
F
G
L
A
H
K
I
-
D
F
G
N
E
-
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
Y
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
-
K
Q
E
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
P
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
33
PsiBlast_CBE
84.54
97%
-71
- C1 -
3GU5
1
DAPK1_HUMAN
A:
[2-294]
-
T
V
F
R
Q
E
N
V
D
D
Y
Y
D
-
T
G
--
E
E
L
G
S
G
V
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
R
T
K
S
S
R
R
G
V
S
R
E
D
I
E
R
E
V
S
I
L
K
E
I
Q
H
-
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
-
F
D
-
F
-
L
A
E
-
K
E
S
---
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
--
L
D
R
N
V
P
K
P
R
I
K
I
I
D
F
G
L
A
H
K
I
-
D
F
G
N
E
-
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
Y
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
-
K
Q
E
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
P
-------------
P
Q
F
----
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
84.29
100%
-89
- C1 -
3ZXT
1
DAPK1_HUMAN
D:
[7-276]
------
E
N
V
D
D
Y
Y
D
-
T
G
--
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
-----------
V
S
R
E
D
I
E
R
E
V
S
I
L
K
E
I
Q
H
-
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
-
F
D
-
F
-
L
A
E
--------
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
--
L
D
R
N
V
P
K
P
R
I
K
I
I
D
F
G
L
A
H
K
I
-
D
-----------
T
P
E
F
V
A
P
E
I
V
N
Y
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
-
K
Q
E
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28
PsiBlast_CBE
84.14
97%
-74
- C1 -
3EH9
1
DAPK1_HUMAN
A:
[1-293]
-
T
V
F
R
Q
E
N
V
D
D
Y
Y
D
-
T
G
--
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
R
T
K
S
S
R
-
G
V
S
R
E
D
I
E
R
E
V
S
I
L
K
E
I
Q
H
-
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
-
F
D
-
F
-
L
A
E
-
K
-
S
---
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
--
L
D
R
N
V
P
K
P
R
I
K
I
I
D
F
G
L
A
H
K
I
-
D
F
G
N
E
-
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
Y
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
-
K
Q
E
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
P
-------------
P
Q
F
----
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
35
PsiBlast_CBE
83.66
97%
-72
- C1 -
1P4F
1
DAPK1_HUMAN
A:
[1-292]
-
T
V
F
R
Q
E
N
V
D
D
Y
Y
D
-
T
G
--
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
R
T
K
S
S
R
R
G
V
S
R
E
D
I
E
R
E
V
S
I
L
K
E
I
Q
H
-
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
-
F
D
-
F
------------
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
--
L
D
R
N
V
P
--
R
I
K
I
I
D
F
G
L
A
H
K
I
-
D
F
G
N
E
-
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
Y
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
-
K
Q
E
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
P
--------------
Q
F
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
PsiBlast_CBE
83.37
100%
-80
- C1 -
3ZXT
1
DAPK1_HUMAN
C:
[5-276]
----
R
Q
E
N
V
D
D
Y
Y
D
-
T
G
--
E
E
L
G
--
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
R
T
K
S
S
R
R
G
V
S
R
E
D
I
E
R
E
V
S
I
L
K
E
I
Q
H
-
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
-
F
D
-
F
-
L
A
E
-
K
E
S
---
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
--
L
D
R
N
V
P
K
P
R
I
K
I
I
D
F
G
L
A
H
K
I
-
D
------------
P
E
F
V
A
P
E
I
V
N
Y
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
-
K
Q
E
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
82.68
100%
-81
- C1 -
3ZXT
1
DAPK1_HUMAN
A:
[7-276]
------
E
N
V
D
D
Y
Y
D
-
T
G
--
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
R
T
--------
R
E
D
I
E
R
E
V
S
I
L
K
E
I
Q
H
-
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
-
F
D
-
F
-
L
A
E
-
K
E
S
---
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
--
L
D
R
-
V
P
K
P
R
I
K
I
I
D
F
G
L
A
H
K
I
-
D
-------------
E
F
V
A
P
E
I
V
N
Y
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
-
K
Q
E
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
46
PsiBlast_CBE
82.64
73%
-74
- C1 -
2CKE
1
DAPK2_HUMAN
B:
[3-302]
-
E
P
F
K
Q
Q
K
V
E
D
F
Y
D
-
I
G
--
E
E
L
G
S
G
Q
F
A
I
V
K
K
C
R
E
K
S
T
G
L
E
Y
A
A
K
F
I
K
K
R
Q
S
R
A
S
R
R
G
V
S
R
E
E
I
E
R
E
V
S
I
L
R
Q
V
L
H
-
H
N
V
I
T
L
H
D
V
Y
E
N
R
T
D
V
V
L
I
L
E
L
V
S
G
G
E
L
-
F
D
-
F
-
L
A
Q
-
K
E
S
---
L
S
E
E
E
A
T
S
F
I
K
Q
I
L
D
G
V
N
Y
L
H
T
K
K
I
A
H
F
D
L
K
P
E
N
I
M
L
--
L
D
K
N
I
P
I
P
H
I
K
L
I
D
F
G
L
A
H
E
I
-
E
D
G
V
E
-
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
Y
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
-
K
Q
E
T
L
A
N
I
T
S
V
S
Y
D
F
D
E
E
F
F
S
H
T
S
E
L
A
K
D
F
I
R
K
L
L
V
K
E
T
R
K
R
L
T
I
Q
E
A
L
R
H
P
W
I
T
P
V
D
N
Q
Q
A
M
V
R
R
E
S
V
V
N
L
----
E
----
N
F
R
K
Q
Y
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
47
PsiBlast_CBE
82.25
73%
-72
- C1 -
2CKE
1
DAPK2_HUMAN
A:
[2-302]
M
E
P
F
K
Q
Q
K
V
E
D
F
Y
D
-
I
G
--
E
E
L
G
S
G
Q
F
A
I
V
K
K
C
R
E
K
S
T
G
L
E
Y
A
A
K
F
I
K
K
R
Q
S
R
A
S
R
R
G
V
S
R
E
E
I
E
R
E
V
S
I
L
R
Q
V
L
H
-
H
N
V
I
T
L
H
D
V
Y
E
N
R
T
D
V
V
L
I
L
E
L
V
S
G
G
E
L
-
F
D
-
F
-
L
A
Q
-
K
E
S
---
L
S
E
E
E
A
T
S
F
I
K
Q
I
L
D
G
V
N
Y
L
H
T
K
K
I
A
H
F
D
L
K
P
E
N
I
M
L
--
L
D
K
N
I
P
I
P
H
I
K
L
I
D
F
G
L
A
H
E
I
-
E
D
G
V
E
-
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
Y
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
-
K
Q
E
T
L
A
N
I
T
S
V
S
Y
D
F
D
E
E
F
F
S
H
T
S
E
L
A
K
D
F
I
R
K
L
L
V
K
E
T
R
K
R
L
T
I
Q
E
A
L
R
H
P
W
I
T
P
V
D
N
Q
Q
A
M
V
R
R
E
S
V
V
N
L
----
E
----
N
F
R
K
Q
Y
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
45
PsiBlast_CBE
81.68
73%
-71
- C1 -
2CKE
1
DAPK2_HUMAN
C:
[3-302]
-
E
P
F
K
Q
Q
K
V
E
D
F
Y
D
-
I
G
--
E
E
L
G
S
G
Q
F
A
I
V
K
K
C
R
E
K
S
T
G
L
E
Y
A
A
K
F
I
K
K
R
Q
S
R
A
S
R
R
G
V
S
R
E
E
I
E
R
E
V
S
I
L
R
Q
V
L
H
-
H
N
V
I
T
L
H
D
V
Y
E
N
R
T
D
V
V
L
I
L
E
L
V
S
G
G
E
L
-
F
D
-
F
-
L
A
Q
-
K
E
S
---
L
S
E
E
E
A
T
S
F
I
K
Q
I
L
D
G
V
N
Y
L
H
T
K
K
I
A
H
F
D
L
K
P
E
N
I
M
L
--
L
D
K
N
I
P
I
P
H
I
K
L
I
D
F
G
L
A
H
E
I
-
E
D
G
V
E
-
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
Y
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
-
K
Q
E
T
L
A
N
I
T
S
V
S
Y
D
F
D
E
E
F
F
S
H
T
S
E
L
A
K
D
F
I
R
K
L
L
V
K
E
T
R
K
R
L
T
I
Q
E
A
L
R
H
P
W
I
T
P
V
D
N
Q
Q
A
M
V
R
R
E
S
V
V
N
L
----
E
----
N
F
R
K
Q
Y
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
44
PsiBlast_CBE
81.60
73%
-70
- C1 -
2CKE
1
DAPK2_HUMAN
D:
[3-302]
-
E
P
F
K
Q
Q
K
V
E
D
F
Y
D
-
I
G
--
E
E
L
G
S
G
Q
F
A
I
V
K
K
C
R
E
K
S
T
G
L
E
Y
A
A
K
F
I
K
K
R
Q
S
R
A
S
R
R
G
V
S
R
E
E
I
E
R
E
V
S
I
L
R
Q
V
L
H
-
H
N
V
I
T
L
H
D
V
Y
E
N
R
T
D
V
V
L
I
L
E
L
V
S
G
G
E
L
-
F
D
-
F
-
L
A
Q
-
K
E
S
---
L
S
E
E
E
A
T
S
F
I
K
Q
I
L
D
G
V
N
Y
L
H
T
K
K
I
A
H
F
D
L
K
P
E
N
I
M
L
--
L
D
K
N
I
P
I
P
H
I
K
L
I
D
F
G
L
A
H
E
I
-
E
D
G
V
E
-
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
Y
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
-
K
Q
E
T
L
A
N
I
T
S
V
S
Y
D
F
D
E
E
F
F
S
H
T
S
E
L
A
K
D
F
I
R
K
L
L
V
K
E
T
R
K
R
L
T
I
Q
E
A
L
R
H
P
W
I
T
P
V
D
N
Q
Q
A
M
V
R
R
E
S
V
V
N
L
----
E
----
N
F
R
K
Q
Y
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
40
PsiBlast_CBE
80.48
72%
-69
- C1 -
2YAA
1
DAPK2_MOUSE
B:
[4-302]
--
T
F
K
Q
Q
K
V
E
D
F
Y
D
-
I
G
--
E
E
L
G
S
G
Q
F
A
I
V
K
K
C
R
E
K
S
T
G
L
E
Y
A
A
K
F
I
K
K
R
Q
S
R
A
S
R
R
G
V
C
R
E
E
I
E
R
E
V
S
I
L
R
Q
V
L
H
-
P
N
I
I
T
L
H
D
V
Y
E
N
R
T
D
V
V
L
I
L
E
L
V
S
G
G
E
L
-
F
D
-
F
-
L
A
Q
-
K
E
S
---
L
S
E
E
E
A
T
S
F
I
K
Q
I
L
D
G
V
N
Y
L
H
T
K
K
I
A
H
F
D
L
K
P
E
N
I
M
L
--
L
D
K
N
I
P
I
P
H
I
K
L
I
D
F
G
L
A
H
E
I
-
E
D
G
V
E
-
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
Y
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
-
K
Q
E
T
L
A
N
I
T
A
V
S
Y
D
F
D
E
E
F
F
S
Q
T
S
E
L
A
K
D
F
I
R
K
L
L
V
K
E
T
R
K
R
L
T
I
Q
E
A
L
R
H
P
W
I
T
P
V
D
T
Q
Q
A
M
V
R
R
E
S
V
V
N
L
----
E
----
N
F
K
K
Q
Y
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
41
PsiBlast_CBE
79.63
72%
-70
- C1 -
2YAA
1
DAPK2_MOUSE
A:
[3-302]
-
E
T
F
K
Q
Q
K
V
E
D
F
Y
D
-
I
G
--
E
E
L
G
S
G
Q
F
A
I
V
K
K
C
R
E
K
S
T
G
L
E
Y
A
A
K
F
I
K
K
R
Q
S
R
A
S
R
R
G
V
C
R
E
E
I
E
R
E
V
S
I
L
R
Q
V
L
H
-
P
N
I
I
T
L
H
D
V
Y
E
N
R
T
D
V
V
L
I
L
E
L
V
S
G
G
E
L
-
F
D
-
F
-
L
A
Q
-
K
E
S
---
L
S
E
E
E
A
T
S
F
I
K
Q
I
L
D
G
V
N
Y
L
H
T
K
K
I
A
H
F
D
L
K
P
E
N
I
M
L
--
L
D
K
N
I
P
I
P
H
I
K
L
I
D
F
G
L
A
H
E
I
-
E
D
G
V
E
-
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
Y
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
-
K
Q
E
T
L
A
N
I
T
A
V
S
Y
D
F
D
E
E
F
F
S
Q
T
S
E
L
A
K
D
F
I
R
K
L
L
V
K
E
T
R
K
R
L
T
I
Q
E
A
L
R
H
P
W
I
T
P
V
D
T
Q
Q
A
M
V
R
R
E
S
V
V
N
L
----
E
----
N
F
K
K
Q
Y
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
60
PsiBlast_CBE
67.52
49%
-68
- C1 -
3LM5
1
ST17B_HUMAN
A:
[24-295]
------
E
N
F
N
N
F
Y
I
L
T
S
--
K
E
L
G
R
G
K
F
A
V
V
R
Q
C
I
S
K
S
T
G
Q
E
Y
A
A
K
F
L
K
K
R
R
----
R
G
Q
D
C
R
A
E
I
L
H
E
I
A
V
L
E
L
A
K
S
C
P
R
V
I
N
L
H
E
V
Y
E
N
T
S
E
I
I
L
I
L
E
Y
A
A
G
G
E
I
-
F
S
-
L
C
L
P
E
L-
E
M
---
V
S
E
N
D
V
I
R
L
I
K
Q
I
L
E
G
V
Y
Y
L
H
Q
N
N
I
V
H
L
D
L
K
P
Q
N
I
-
L
--
L
S
S
I
Y
P
L
G
D
I
K
I
V
D
F
G
M
S
R
K
I
-----------
M
G
T
P
E
Y
L
A
P
E
I
L
N
Y
D
P
I
T
T
A
T
D
M
W
N
I
G
I
I
A
Y
M
L
L
T
H
T
S
P
F
V
G
E
D
-
N
Q
E
T
Y
L
N
I
S
Q
V
N
V
D
Y
S
E
E
T
F
S
S
V
S
Q
L
A
T
D
F
I
Q
S
L
L
V
K
N
P
E
K
R
P
T
A
E
I
C
L
S
H
S
W
L
Q
Q
W
D
F
E
N
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
61
PsiBlast_CBE
66.34
49%
-66
- C1 -
3LM0
2
ST17B_HUMAN
A:
[24-295]
------
E
N
F
N
N
F
Y
I
L
T
S
--
K
E
L
G
R
G
K
F
A
V
V
R
Q
C
I
S
K
S
T
G
Q
E
Y
A
A
K
F
L
K
K
R
R
----
R
G
Q
D
C
R
A
E
I
L
H
E
I
A
V
L
E
L
A
K
S
C
P
R
V
I
N
L
H
E
V
Y
E
N
T
S
E
I
I
L
I
L
E
Y
A
A
G
G
E
I
-
F
S
-
L
C
L
P
E
L
A
E
M
---
V
S
E
N
D
V
I
R
L
I
K
Q
I
L
E
G
V
Y
Y
L
H
Q
N
N
I
V
H
L
D
L
K
P
Q
N
I
-
L
--
L
S
S
I
Y
P
L
G
D
I
K
I
V
D
F
G
M
S
R
K
I
-----------
M
G
T
P
E
Y
L
A
P
E
I
L
N
Y
D
P
I
T
T
A
T
D
M
W
N
I
G
I
I
A
Y
M
L
L
T
H
T
S
P
F
V
G
E
D
-
N
Q
E
T
Y
L
N
I
S
Q
V
N
V
D
Y
S
E
E
T
F
S
S
V
S
Q
L
A
T
D
F
I
Q
S
L
L
V
K
N
P
E
K
R
P
T
A
E
I
C
L
S
H
S
W
L
Q
Q
W
D
F
E
N
L
F
H
P
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
73
PsiBlast_CBE
65.58
39%
-70
- C1 -
4FG8
1
KCC1A_HUMAN
A:
[12-299]
----
Q
A
E
D
I
R
D
I
Y
D
-
F
R
--
D
V
L
G
T
G
A
F
S
E
V
I
L
A
E
D
K
R
T
Q
K
L
V
A
I
K
C
I
A
K
E
---------------
N
E
I
A
V
L
H
K
I
K
H
-
P
N
I
V
A
L
D
D
I
Y
E
S
G
G
H
L
Y
L
I
M
Q
L
V
S
G
G
E
L
-
F
D
-
R
-
I
V
E
-
K
G
F
---
Y
T
E
R
D
A
S
R
L
I
F
Q
V
L
D
A
V
K
Y
L
H
D
L
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
YS
L
D
E
D
---
S
K
I
M
I
S
D
F
-------------------
T
P
G
Y
V
A
P
E
V
L
A
Q
K
P
Y
S
K
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
Y
D
E
N
-
D
A
K
L
F
E
Q
I
L
K
A
E
Y
E
F
D
S
P
Y
W
D
D
I
S
D
S
A
K
D
F
I
R
H
L
M
E
K
D
P
E
K
R
F
T
C
E
Q
A
L
Q
H
P
W
I
-
A
G
D
T
--
A
L
D
K
N
I
H
Q
S
V
S
----
E
----
Q
I
K
K
N
F
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
72
PsiBlast_CBE
65.58
39%
-68
- C1 -
4FG8
1
KCC1A_HUMAN
B:
[14-299]
------
E
D
I
R
D
I
Y
D
-
F
R
--
D
V
L
G
T
G
A
F
S
E
V
I
L
A
E
D
K
R
T
Q
K
L
V
A
I
K
C
I
A
K
----------------
N
E
I
A
V
L
H
K
I
K
H
-
P
N
I
V
A
L
D
D
I
Y
E
S
G
G
H
L
Y
L
I
M
Q
L
V
S
G
G
E
L
-
F
D
-
R
-
I
V
E
-
K
G
F
---
Y
T
E
R
D
A
S
R
L
I
F
Q
V
L
D
A
V
K
Y
L
H
D
L
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
YS
L
D
E
D
---
S
K
I
M
I
S
D
F
G
--------
G
S
V
-
L
S
T
A
C
G
T
P
G
Y
V
A
P
E
V
L
A
Q
K
P
Y
S
K
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
Y
D
E
N
-
D
A
K
L
F
E
Q
I
L
K
A
E
Y
E
F
D
S
P
Y
W
D
D
I
S
D
S
A
K
D
F
I
R
H
L
M
E
K
D
P
E
K
R
F
T
C
E
Q
A
L
Q
H
P
W
I
-
A
G
D
T
--
A
L
D
K
N
I
H
Q
S
V
S
----
E
----
Q
I
K
K
N
F
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
68
PsiBlast_CBE
64.56
36%
-62
- C1 -
2JC6
1
KCC1D_HUMAN
A:
[16-314]
----
Q
A
E
D
I
K
K
I
F
E
-
F
K
--
E
T
L
G
T
G
A
F
S
E
V
V
L
A
E
E
K
A
T
G
K
L
F
A
V
K
C
I
P
K
K
A
-----
S
S
-----
I
E
N
E
I
A
V
L
R
K
I
K
H
-
E
N
I
V
A
L
E
D
I
Y
E
S
P
N
H
L
Y
L
V
M
Q
L
V
S
G
G
E
L
-
F
D
-
R
-
I
V
E
-
K
G
F
---
Y
T
E
K
D
A
S
T
L
I
R
Q
V
L
D
A
V
Y
Y
L
H
R
M
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
--
Y
S
Q
D
-
E
E
S
K
I
M
I
S
----------------------
P
G
Y
V
A
P
E
V
L
A
Q
K
P
Y
S
K
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
Y
D
E
N
-
D
S
K
L
F
E
Q
I
L
K
A
E
Y
E
F
D
S
P
Y
W
D
D
I
S
D
S
A
K
D
F
I
R
N
L
M
E
K
D
P
N
K
R
Y
T
C
E
Q
A
A
R
H
P
W
I
-
A
G
D
T
--
A
L
N
K
N
I
H
E
S
V
S
----
A
----
Q
I
R
K
N
F
A
K
S
K
W
R
Q
A
F
N
A
T
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
67
PsiBlast_CBE
63.73
36%
-61
- C1 -
2JC6
1
KCC1D_HUMAN
C:
[16-314]
----
Q
A
E
D
I
K
K
I
F
E
-
F
K
--
E
T
L
G
T
G
A
F
S
E
V
V
L
A
E
E
K
A
T
G
K
L
F
A
V
K
C
I
P
K
K
A
------
S
-----
I
E
N
E
I
A
V
L
R
K
I
K
H
-
E
N
I
V
A
L
E
D
I
Y
E
S
P
N
H
L
Y
L
V
M
Q
L
V
S
G
G
E
L
-
F
D
-
R
-
I
V
E
-
K
G
F
---
Y
T
E
K
D
A
S
T
L
I
R
Q
V
L
D
A
V
Y
Y
L
H
R
M
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
--
Y
S
Q
D
-
E
E
S
K
I
M
I
S
----------------------
P
G
Y
V
A
P
E
V
L
A
Q
K
P
Y
S
K
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
Y
D
E
N
-
D
S
K
L
F
E
Q
I
L
K
A
E
Y
E
F
D
S
P
Y
W
D
D
I
S
D
S
A
K
D
F
I
R
N
L
M
E
K
D
P
N
K
R
Y
T
C
E
Q
A
A
R
H
P
W
I
-
A
G
D
T
--
A
L
N
K
N
I
H
E
S
V
S
----
A
----
Q
I
R
K
N
F
A
K
S
K
W
R
Q
A
F
N
A
T
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
63
PsiBlast_CBE
63.60
44%
-74
- C1 -
2X4F
3
MYLK4_HUMAN
B:
[81-355]
----
K
Q
G
A
V
N
S
F
Y
T
-
V
S
KT
E
I
L
G
G
G
--
G
Q
V
H
K
C
E
E
T
A
T
G
L
K
L
A
A
K
I
I
K
T
R
G
M
K
D
------
K
E
E
V
K
N
E
I
S
V
M
N
Q
L
D
H
-
A
N
L
I
Q
L
Y
D
A
F
E
S
K
N
D
I
V
L
V
M
E
Y
V
D
G
G
E
L
-
F
D
R
I
-
I
D
E
-
S
Y
N
---
L
T
E
L
D
T
I
L
F
M
K
Q
I
C
E
G
I
R
H
M
H
Q
M
Y
I
L
H
L
D
L
K
P
E
N
I
L
C
--
V
N
R
D
A
K
--
Q
I
K
I
I
D
F
G
L
A
R
R
Y
-
K
P
R
E
K
-
L
K
V
N
F
G
T
P
E
F
L
A
P
E
V
V
N
Y
D
F
V
S
F
P
T
D
M
W
S
V
G
V
I
A
Y
M
L
L
S
G
L
S
P
F
L
G
D
N
-
D
A
E
T
L
N
N
I
L
A
C
R
W
D
L
E
D
E
E
F
Q
D
I
S
E
E
A
K
E
F
I
S
K
L
L
I
K
E
K
S
W
R
I
S
A
S
E
A
L
K
H
P
W
L
S
D
H
K
L
H
S
R
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
75
PsiBlast_CBE
63.39
40%
-80
- C1 -
4FG7
1
KCC1A_HUMAN
A:
[12-276]
----
Q
A
E
D
I
R
D
I
Y
D
-
F
R
--
D
V
L
G
T
G
A
F
S
E
V
I
L
A
E
D
K
R
T
Q
K
L
V
A
I
K
C
I
A
---------
S
-----
M
E
N
E
I
A
V
L
H
K
I
K
H
-
P
N
I
V
A
L
D
D
I
Y
E
S
G
G
H
L
Y
L
I
M
Q
L
V
S
G
G
E
L
-
F
D
-
R
-
I
V
E
-
K
G
F
---
Y
T
E
R
D
A
S
R
L
I
F
Q
V
L
D
A
V
K
Y
L
H
D
L
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
YS
L
D
E
D
---
S
K
I
M
I
S
D
F
G
L
S
K
M
E
-
D
P
G
---------
T
P
G
Y
V
A
P
E
V
L
A
Q
K
--
S
K
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
Y
D
E
N
-
D
A
K
L
F
E
Q
I
L
K
A
E
Y
E
F
D
S
P
Y
W
D
D
I
S
D
S
A
K
D
F
I
R
H
L
M
E
K
D
P
E
K
R
F
T
C
E
Q
A
L
Q
H
P
W
I
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
76
PsiBlast_CBE
63.37
38%
-59
- C1 -
2JAM
3
KCC1G_HUMAN
B:
[6-289]
-------
N
I
R
K
T
F
I
-
F
M
--
E
V
L
G
S
G
A
F
S
E
V
F
L
V
K
Q
R
L
T
G
K
L
F
A
L
K
C
I
K
K
------------
S
S
L
E
N
E
I
A
V
L
K
K
I
K
H
-
E
N
I
V
T
L
E
D
I
Y
E
S
T
T
H
Y
Y
L
V
M
Q
L
V
S
G
G
E
L
-
F
D
-
R
-
I
L
E
-
R
G
V
---
Y
T
E
K
D
A
S
L
V
I
Q
Q
V
L
S
A
V
K
Y
L
H
E
N
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
--
L
T
P
E
-
E
N
S
K
I
M
I
T
D
F
G
L
S
-
K
M
-
E
Q
N
G
I
-
M
S
T
A
C
G
T
P
G
Y
V
A
P
E
V
L
A
Q
K
P
Y
S
K
A
V
D
C
W
S
I
G
V
I
T
Y
I
L
L
C
G
Y
P
P
F
Y
E
E
T
-
E
S
K
L
F
E
K
I
K
E
G
Y
Y
E
F
E
S
P
F
W
D
D
I
S
E
S
A
K
D
F
I
C
H
L
L
E
K
D
P
N
E
R
Y
T
C
E
K
A
L
S
H
P
W
I
---
D
G
N
T
A
L
H
R
D
I
Y
P
S
V
S
----
L
----
Q
I
Q
K
N
F
A
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
77
PsiBlast_CBE
62.67
38%
-58
- C1 -
2JAM
3
KCC1G_HUMAN
A:
[6-290]
-------
N
I
R
K
T
F
I
-
F
M
--
E
V
L
G
S
G
A
F
S
E
V
F
L
V
K
Q
R
L
T
G
K
L
F
A
L
K
C
I
K
K
------------
S
S
L
E
N
E
I
A
V
L
K
K
I
K
H
-
E
N
I
V
T
L
E
D
I
Y
E
S
T
T
H
Y
Y
L
V
M
Q
L
V
S
G
G
E
L
-
F
D
-
R
-
I
L
E
-
R
G
V
---
Y
T
E
K
D
A
S
L
V
I
Q
Q
V
L
S
A
V
K
Y
L
H
E
N
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
--
L
T
P
E
-
E
N
S
K
I
M
I
T
D
F
G
L
S
-
K
M
-
E
Q
N
G
I
-
M
S
T
A
C
G
T
P
G
Y
V
A
P
E
V
L
A
Q
K
P
Y
S
K
A
V
D
C
W
S
I
G
V
I
T
Y
I
L
L
C
G
Y
P
P
F
Y
E
E
T
-
E
S
K
L
F
E
K
I
K
E
G
Y
Y
E
F
E
S
P
F
W
D
D
I
S
E
S
A
K
D
F
I
C
H
L
L
E
K
D
P
N
E
R
Y
T
C
E
K
A
L
S
H
P
W
I
---
D
G
N
T
A
L
H
R
D
I
Y
P
S
V
S
----
L
----
Q
I
Q
K
N
F
A
K
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
79
PsiBlast_CBE
62.31
34%
-62
- C1 -
2WEL
7
KCC2D_HUMAN
A:
[1-308]
-------
S
M
T
D
E
Y
Q
-
L
F
--
E
E
L
G
K
G
A
F
S
V
V
R
R
C
M
K
I
P
T
G
Q
E
Y
A
A
K
I
I
N
T
K
K
L
-
S
A
R
---
D
H
Q
K
L
E
R
E
A
R
I
C
R
L
L
K
H
-
P
N
I
V
R
L
H
D
S
I
S
E
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
-
F
E
-
D
-
I
V
A
-
R
E
Y
---
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
L
N
G
I
V
H
R
D
L
K
P
E
N
L
L
L
--
A
S
K
S
-
K
G
A
A
V
K
L
A
D
F
G
L
A
I
E
V
-
Q
G
D
Q
Q
A
W
F
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
R
K
D
P
Y
G
K
P
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
D
E
D
-
Q
H
R
L
Y
Q
Q
I
K
A
G
A
Y
D
F
P
S
P
E
W
D
T
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
A
K
R
I
T
A
S
E
A
L
K
H
P
W
I
C
Q
R
----
S
M
M
H
R
Q
E
T
V
D
C
----------
L
K
K
F
N
A
R
R
K
L
K
G
A
I
L
T
T
M
L
A
T
R
---------
N
F
S
A
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
64
PsiBlast_CBE
61.94
44%
-69
- C1 -
2X4F
4
MYLK4_HUMAN
A:
[81-356]
----
K
Q
G
A
V
N
S
F
Y
T
-
V
S
KT
E
I
L
G
-----
Q
V
H
K
C
E
E
T
A
T
G
L
K
L
A
A
K
I
I
K
T
R
G
M
K
D
------
K
E
E
V
K
N
E
I
S
V
M
N
Q
L
D
H
-
A
N
L
I
Q
L
Y
D
A
F
E
S
K
N
D
I
V
L
V
M
E
Y
V
D
G
G
E
L
-
F
D
R
I
-
I
D
E
-
S
Y
N
---
L
T
E
L
D
T
I
L
F
M
K
Q
I
C
E
G
I
R
H
M
H
Q
M
Y
I
L
H
L
D
L
K
P
E
N
I
L
C
--
V
N
R
D
A
K
--
Q
I
K
I
I
D
F
G
L
A
R
R
Y
-
K
P
R
E
K
-
L
K
V
N
F
G
T
P
E
F
L
A
P
E
V
V
N
Y
D
F
V
S
F
P
T
D
M
W
S
V
G
V
I
A
Y
M
L
L
S
G
L
S
P
F
L
G
D
N
-
D
A
E
T
L
N
N
I
L
A
C
R
W
D
L
E
D
E
E
F
Q
D
I
S
E
E
A
K
E
F
I
S
K
L
L
I
K
E
K
S
W
R
I
S
A
S
E
A
L
K
H
P
W
L
S
D
H
K
L
H
S
R
L
S
A
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
81
PsiBlast_CBE
61.49
34%
-55
- C1 -
2VN9
2
KCC2D_HUMAN
A:
[1-296]
-------
S
M
T
D
E
Y
Q
-
L
F
--
E
E
L
G
K
G
A
F
S
V
V
R
R
C
M
K
I
P
T
G
Q
E
Y
A
A
K
I
I
N
T
K
K
L
S
A
R
----
D
H
Q
K
L
E
R
E
A
R
I
C
R
L
L
K
H
-
P
N
I
V
R
L
H
D
S
I
S
E
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
-
F
E
-
D
-
I
V
A
-
R
E
Y
---
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
L
N
G
I
V
H
R
D
L
K
P
E
N
L
L
L
--
A
S
K
S
-
K
G
A
A
V
K
L
A
D
F
G
L
A
I
E
V
-
Q
G
D
Q
Q
A
W
F
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
R
K
D
P
Y
G
K
P
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
D
E
D
-
Q
H
R
L
Y
Q
Q
I
K
A
G
A
Y
D
F
P
S
P
E
W
D
T
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
A
K
R
I
T
A
S
E
A
L
K
H
P
W
I
C
Q
R
S
T
V
A
S
M
M
H
R
Q
E
T
V
D
C
----------
L
K
K
F
N
A
R
R
K
L
K
G
A
I
L
T
T
M
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
84
PsiBlast_CBE
61.19
35%
-60
- C1 -
3MFS
1
CSKP_HUMAN
A:
[23-320]
---------
E
D
V
Y
E
-
L
C
--
E
V
I
G
K
G
A
F
S
V
V
R
R
C
I
N
R
E
T
G
Q
Q
F
A
V
K
I
V
D
V
A
K
F
T
S
S
P
-
G
L
S
T
E
D
L
K
R
E
A
S
I
C
H
M
L
K
H
-
P
H
I
V
E
L
L
E
T
Y
S
S
D
G
M
L
Y
M
V
F
E
F
M
D
G
A
D
L
C
F
E
-
I
-
V
K
R
-
A
D
A
G
F
V
Y
S
E
A
V
A
S
H
Y
M
R
Q
I
L
E
A
L
R
Y
C
H
D
N
N
I
I
H
R
D
V
K
P
E
N
V
L
L
--
A
S
K
E
N
S
A
P
-
V
K
L
G
D
F
G
V
A
I
Q
L
G
E
S
G
L
V
-
A
G
G
R
V
G
T
P
H
F
M
A
P
E
V
V
K
R
E
P
Y
G
K
P
V
D
V
W
G
C
G
V
I
L
F
I
L
L
S
G
C
L
P
F
Y
G
-
T
-
K
E
R
L
F
E
G
I
I
K
G
K
Y
K
M
N
P
R
Q
W
S
H
I
S
E
S
A
K
D
L
V
R
R
M
L
M
L
D
P
A
E
R
I
T
V
Y
E
A
L
N
H
P
W
L
K
E
R
D
------
R
Y
A
Y
K
I
H
L
P
E
T
V
E
----
Q
L
R
K
F
N
A
R
R
K
L
K
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
80
PsiBlast_CBE
61.15
34%
-54
- C1 -
2VN9
1
KCC2D_HUMAN
B:
[1-296]
-------
S
M
T
D
E
Y
Q
-
L
F
--
E
E
L
G
K
G
A
F
S
V
V
R
R
C
M
K
I
P
T
G
Q
E
Y
A
A
K
I
I
N
T
K
K
L
S
A
R
----
D
H
Q
K
L
E
R
E
A
R
I
C
R
L
L
K
H
-
P
N
I
V
R
L
H
D
S
I
S
E
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
-
F
E
-
D
-
I
V
A
-
R
E
Y
---
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
L
N
G
I
V
H
R
D
L
K
P
E
N
L
L
L
--
A
S
K
S
-
K
G
A
A
V
K
L
A
D
F
G
L
A
I
E
V
-
Q
G
D
Q
Q
A
W
F
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
R
K
D
P
Y
G
K
P
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
D
E
D
-
Q
H
R
L
Y
Q
Q
I
K
A
G
A
Y
D
F
P
S
P
E
W
D
T
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
A
K
R
I
T
A
S
E
A
L
K
H
P
W
I
C
Q
R
S
T
V
A
S
M
M
H
R
Q
E
T
V
D
C
----------
L
K
K
F
N
A
R
R
K
L
K
G
A
I
L
T
T
M
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
69
PsiBlast_CBE
61.12
38%
-62
- C1 -
2W4O
1
KCC4_HUMAN
A:
[48-346]
-----
R
D
A
L
S
D
F
F
E
-
V
E
--
S
E
L
G
R
G
A
T
S
I
V
Y
R
C
K
Q
K
G
T
Q
K
P
Y
A
L
K
V
L
K
K
------------------
I
G
V
L
L
R
L
S
H
-
P
N
I
I
K
L
K
E
I
F
E
T
P
T
E
I
S
L
V
L
E
L
V
T
G
G
E
L
-
F
D
-
R
-
I
V
E
-
K
G
Y
---
Y
S
E
R
D
A
A
D
A
V
K
Q
I
L
E
A
V
A
Y
L
H
E
N
G
I
V
H
R
D
L
K
P
E
N
-
L
L
--
Y
A
T
P
A
P
D
A
P
L
K
I
A
D
F
------------------
G
T
P
G
Y
C
A
P
E
I
L
R
G
C
A
Y
G
P
E
V
D
M
W
S
V
G
I
I
T
Y
I
L
L
C
G
F
E
P
F
Y
D
E
R
G
D
Q
F
M
F
R
R
I
L
N
C
E
Y
Y
F
I
S
P
W
W
D
E
V
S
L
N
A
K
D
L
V
R
K
L
I
V
L
D
P
K
K
R
L
T
T
F
Q
A
L
Q
H
P
W
V
T
G
K
--------
A
A
N
F
V
H
M
----
D
T
A
Q
K
K
L
Q
E
F
N
A
R
R
K
L
K
A
A
V
K
A
V
V
A
S
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
85
PsiBlast_CBE
60.96
35%
-59
- C1 -
3MFR
1
CSKP_HUMAN
A:
[23-320]
---------
E
D
V
Y
E
-
L
C
--
E
V
I
G
K
G
A
F
S
V
V
R
R
C
I
N
R
E
T
G
Q
Q
F
A
V
K
I
V
D
V
A
K
F
T
S
S
P
-
G
L
S
T
E
D
L
K
R
E
A
S
I
C
H
M
L
K
H
-
P
H
I
V
E
L
L
E
T
Y
S
S
D
G
M
L
Y
M
V
F
E
F
M
D
G
A
D
L
C
F
E
-
I
-
V
K
R
-
A
D
A
G
F
V
Y
S
E
A
V
A
S
H
Y
M
R
Q
I
L
E
A
L
R
Y
C
H
D
N
N
I
I
H
R
D
V
K
P
E
N
V
L
L
--
A
S
K
E
N
S
A
P
-
V
K
L
G
D
F
G
V
A
I
Q
L
G
E
S
G
L
V
-
A
G
G
R
V
G
T
P
H
F
M
A
P
E
V
V
K
R
E
P
Y
G
K
P
V
D
V
W
G
C
G
V
I
L
F
I
L
L
S
G
C
L
P
F
Y
G
-
T
-
K
E
R
L
F
E
G
I
I
K
G
K
Y
K
M
N
P
R
Q
W
S
H
I
S
E
S
A
K
D
L
V
R
R
M
L
M
L
D
P
A
E
R
I
T
V
Y
E
A
L
N
H
P
W
L
K
E
R
D
------
R
Y
A
Y
K
I
H
L
P
E
T
V
E
----
Q
L
R
K
F
N
A
R
R
K
L
K
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
83
PsiBlast_CBE
60.85
35%
-56
- C1 -
3MFU
1
CSKP_HUMAN
A:
[23-320]
---------
E
D
V
Y
E
-
L
C
--
E
V
I
G
K
G
A
F
S
V
V
R
R
C
I
N
R
E
T
G
Q
Q
F
A
V
K
I
V
D
V
A
K
F
T
S
S
P
-
G
L
S
T
E
D
L
K
R
E
A
S
I
C
H
M
L
K
H
-
P
H
I
V
E
L
L
E
T
Y
S
S
D
G
M
L
Y
M
V
F
E
F
M
D
G
A
D
L
C
F
E
-
I
-
V
K
R
-
A
D
A
G
F
V
Y
S
E
A
V
A
S
H
Y
M
R
Q
I
L
E
A
L
R
Y
C
H
D
N
N
I
I
H
R
D
V
K
P
E
N
V
L
L
--
A
S
K
E
N
S
A
P
-
V
K
L
G
D
F
G
V
A
I
Q
L
G
E
S
G
L
V
-
A
G
G
R
V
G
T
P
H
F
M
A
P
E
V
V
K
R
E
P
Y
G
K
P
V
D
V
W
G
C
G
V
I
L
F
I
L
L
S
G
C
L
P
F
Y
G
-
T
-
K
E
R
L
F
E
G
I
I
K
G
K
Y
K
M
N
P
R
Q
W
S
H
I
S
E
S
A
K
D
L
V
R
R
M
L
M
L
D
P
A
E
R
I
T
V
Y
E
A
L
N
H
P
W
L
K
E
R
D
------
R
Y
A
Y
K
I
H
L
P
E
T
V
E
----
Q
L
R
K
F
N
A
R
R
K
L
K
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
71
PsiBlast_CBE
60.48
38%
-59
- C1 -
4FG9
1
KCC1A_HUMAN
A:
[12-314]
----
Q
A
E
D
I
R
D
I
Y
D
-
F
R
--
D
V
L
G
T
G
A
F
S
E
V
I
L
A
E
D
K
R
T
Q
K
L
V
A
I
K
C
I
A
K
E
--------------
E
N
E
I
A
V
L
H
K
I
K
H
-
P
N
I
V
A
L
D
D
I
Y
E
S
G
G
H
L
Y
L
I
M
Q
L
V
S
G
G
E
L
-
F
D
-
R
-
I
V
E
-
K
G
F
---
Y
T
E
R
D
A
S
R
L
I
F
Q
V
L
D
A
V
K
Y
L
H
D
L
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
YS
L
D
E
D
---
S
K
I
M
I
S
D
F
--------------------
P
G
Y
V
A
P
E
V
L
A
Q
K
P
Y
S
K
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
Y
D
E
N
-
D
A
K
L
F
E
Q
I
L
K
A
E
Y
E
F
D
S
P
Y
W
D
D
I
S
D
S
A
K
D
F
I
R
H
L
M
E
K
D
P
E
K
R
F
T
C
E
Q
A
L
Q
H
P
W
I
-
A
G
D
T
--
A
L
D
K
N
I
H
Q
S
V
S
----
E
----
Q
I
K
K
N
F
A
K
S
K
W
K
Q
A
F
N
A
T
A
V
V
R
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
70
PsiBlast_CBE
60.06
38%
-60
- C1 -
4FG9
1
KCC1A_HUMAN
B:
[14-314]
------
E
D
I
R
D
I
Y
D
-
F
R
--
D
V
L
G
T
G
A
F
S
E
V
I
L
A
E
D
K
R
T
Q
K
L
V
A
I
K
C
I
A
K
-----------------
E
I
A
V
L
H
K
I
K
H
-
P
N
I
V
A
L
D
D
I
Y
E
S
G
G
H
L
Y
L
I
M
Q
L
V
S
G
G
E
L
-
F
D
-
R
-
I
V
E
-
K
G
F
---
Y
T
E
R
D
A
S
R
L
I
F
Q
V
L
D
A
V
K
Y
L
H
D
L
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
YS
L
D
E
D
---
S
K
I
M
I
S
D
F
-----------
V
-
L
S
T
A
C
G
T
P
G
Y
V
A
P
E
V
L
A
Q
K
P
Y
S
K
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
Y
D
E
N
-
D
A
K
L
F
E
Q
I
L
K
A
E
Y
E
F
D
S
P
Y
W
D
D
I
S
D
S
A
K
D
F
I
R
H
L
M
E
K
D
P
E
K
R
F
T
C
E
Q
A
L
Q
H
P
W
I
-
A
G
D
T
--
A
L
D
K
N
I
H
Q
S
V
S
----
E
----
Q
I
K
K
N
F
A
K
S
K
W
K
Q
A
F
N
A
T
A
V
V
R
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------