@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : DCLK1_HUMAN: (2015-10-06 )
MSFGRDMELEHFDERDKAQRYSRGSRVNGLPSPTHSAHCSFYRTRTLQTLSSEKKAKKVRFYRNGDRYFKGIVYAISPDRFRSFEALLADLTRTLSDNVNLPQGVRTIYTIDGLKKISSLDQLVEGESYVCGSIEPFKKLEYTKNVNPNWSVNVKTTSASRAVSSLATAKGSPSEVRENKDFIRPKLVTIIRSGVKPRKAVRILLNKKTAHSFEQVLTDITDAIKLDSGVVKRLYTLDGKQVMCLQDFFGDDDIFIACGPEKFRYQDDFLLDESECRVVKSTSYTKIASSSRRSTTKSPGPSRRSKSPASTSSVNGTPGSQLSTPRSGKSPSPSPTSPGSLRKQRSSQHGGSSTSLASTKVCSSMDENDGPGEEVSEEGFQIPATITERYKVGRTIGDGNFAVVKECVERSTAREYALKIIKKSKCRGKEHMIQNEVSILRRVKHPNIVLLIEEMDVPTELYLVMELVKGGDLFDAITSTNKYTERDASGMLYNLASAIKYLHSLNIVHRDIKPENLLVYEHQDGSKSLKLGDFGLATIVDGPLYTVCGTPTYVAPEIIAETGYGLKVDIWAAGVITYILLCGFPPFRGSGDDQEVLFDQILMGQVDFPSPYWDNVSDSAKELITMMLLVDVDQRFSAVQVLEHPWVNDDGLPENEHQLSVAGKIKKHFNTGPKPNSTAAGVSVIATTALDKERQVFRRRRNQDVRSRYKAQPAPPELNSESEDYSPSSSETVRSPNSPF
Atome Classification :
(65 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380...---....390.......400.......410.......420.......430---.--.-----...-------....440.-.-.....450.......460.......470.......480.......490.......500.......510.......520.......530.....-..-----540-.--.---...-....550.......------560..-.....570.......580.......590..-.....600.......610.......620.......630.......640....-.----..650.......660.......670.......680.......690..---.....700.......710.......720.......730.......740
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MSFGRDM
E
L
E
HFD
E
R
D
K
A
Q
R
YSRGSRVNGLPSPTHSA
H
C
S
F
Y
R
T
R
T
L
Q
T
L
S
SEKKA
K
K
V
R
F
Y
RNGD
R
Y
F
K
G
I
V
Y
A
I
S
P
D
R
F
R
S
F
E
A
L
L
A
D
L
T
R
T
L
SDNVNLPQG
V
R
T
I
Y
T
I
D
G
L
K
K
I
S
S
L
D
Q
L
VEGE
S
Y
VCGSI
E
P
F
K
K
L
E
YTKNVNP
N
W
S
V
N
V
K
TT
S
A
S
R
A
V
S
S
L
ATAKG
S
P
S
E
V
R
ENKDF
I
R
P
K
L
V
T
I
I
R
SGV
K
P
R
K
A
V
R
I
L
LNKK
T
A
H
S
F
E
Q
V
L
T
D
I
T
D
A
I
KL
D
S
G
V
V
K
R
L
YTLDG
K
Q
V
M
C
L
Q
D
FFGDD
D
I
F
I
A
CGPEKFRYQDDFLLDESE
C
R
V
V
KSTS
Y
T
K
IASSSRRSTTKSPGPSRRSKSPASTSSVNGTPGSQLSTPRSGKSPSPSPTS
P
G
S
L
R
K
Q
R
SSQHGGSSTSL
A
S
T
K
V
CSSMDENDGPG
E
E
V
S
EEGFQI
P
A
T
---
I
T
E
R
YKVG
R
T
IGD
G
N
F
A
V
V
K
E
C
V
E
R
S
T
A
R
E
Y
A
L
K
I
I
K
KSKCR
G
K
E
-----
H
--
M
-----
I
Q
N
-------
E
V
S
I
L
R
RV-K-HP
N
I
V
L
L
I
EEMDV
P
T
E
L
Y
L
V
M
E
L
VKGG
D
L
F
D
A
I
TSTNKYTERDAS
G
M
L
Y
N
L
A
S
A
I
K
Y
L
H
S
L
N
I
V
HRDIKPE
N
L
L
V
Y
EHQDGSKSLKLGDFG
L
A
-
T
I-----V---D--G---P
L
Y
-
T
VCGTPTY
V
A
P
E
I
I
------AETGY-
G
L
K
V
D
I
W
A
A
G
V
I
T
Y
I
L
LCGFPPFRGSGD
D
Q
-
E
V
L
F
D
Q
I
L
MGQVDFPSPYWDNV
S
D
S
A
K
E
L
I
T
M
M
L
L
VD
V
D
Q
R
F
S
A
V
Q
V
L
EHPW-V----NDDGLPEN
E
H
Q
L
S
V
A
G
K
I
K
K
H
FNTGPKPNSTAA
G
V
S
V
I
A
TTAL
D
K
E
R
---
Q
V
F
R
R
RR
N
Q
D
V
R
S
RYKAQPAPPELNSESEDYSPSSSETVRSPNSPF
3
PsiBlast_PDB
81.91
46%
-106
- C1 -
4FG9
1
KCC1A_HUMAN
A:
[16-298]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
R
D
I
Y
D
F
R
D
V
L
G
T
G
A
F
S
E
V
I
L
A
E
D
K
R
T
Q
K
L
V
A
I
K
C
I
A
K
E
---------------------
E
N
-------
E
I
A
V
L
H
K
I
-
K
-
H
P
N
I
V
A
L
D
D
I
Y
E
S
G
G
H
L
Y
L
I
M
Q
L
V
S
G
G
E
L
F
D
R
I
V
E
K
G
F
Y
T
E
R
D
A
S
R
L
I
F
Q
V
L
D
A
V
K
Y
L
H
D
L
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
Y
S
L
D
E
D
S
K
-
I
M
I
S
D
F
-------------------------------
P
G
Y
V
A
P
E
V
L
------
A
Q
K
P
Y
-
S
K
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
Y
D
E
N
D
A
K
---
L
F
E
Q
I
L
K
A
E
Y
E
F
D
S
P
Y
W
D
D
I
S
D
S
A
K
D
F
I
R
H
L
M
E
K
D
P
E
K
R
F
T
C
E
Q
A
L
Q
H
P
W
-
I
A---
G
D
T
A
L
D
K
N
I
H
Q
-
S
V
S
E
Q
I
K
K
N
F
A
K
S
K
W
K
Q
A
F
N
A
T
A
V
V
R
----------------------------------------------------------
6
PsiBlast_PDB
81.85
46%
-107
- C1 -
4FG8
1
KCC1A_HUMAN
A:
[16-298]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
R
D
I
Y
D
F
R
D
V
L
G
T
G
A
F
S
E
V
I
L
A
E
D
K
R
T
Q
K
L
V
A
I
K
C
I
A
K
E
----------------------
N
-------
E
I
A
V
L
H
K
I
-
K
-
H
P
N
I
V
A
L
D
D
I
Y
E
S
G
G
H
L
Y
L
I
M
Q
L
V
S
G
G
E
L
F
D
R
I
V
E
K
G
F
Y
T
E
R
D
A
S
R
L
I
F
Q
V
L
D
A
V
K
Y
L
H
D
L
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
Y
S
L
D
E
D
S
K
-
I
M
I
S
D
F
------------------------------
T
P
G
Y
V
A
P
E
V
L
------
A
Q
K
P
Y
-
S
K
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
Y
D
E
N
D
A
K
---
L
F
E
Q
I
L
K
A
E
Y
E
F
D
S
P
Y
W
D
D
I
S
D
S
A
K
D
F
I
R
H
L
M
E
K
D
P
E
K
R
F
T
C
E
Q
A
L
Q
H
P
W
-
I
A---
G
D
T
A
L
D
K
N
I
H
Q
-
S
V
S
E
Q
I
K
K
N
F
A
-------------------------------------------------------------------------
22
PsiBlast_CBE
80.80
46%
-110
- C1 -
4FG9
1
KCC1A_HUMAN
B:
[16-298]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
R
D
I
Y
D
F
R
D
V
L
G
T
G
A
F
S
E
V
I
L
A
E
D
K
R
T
Q
K
L
V
A
I
K
C
I
A
K
-------------------------------
E
I
A
V
L
H
K
I
-
K
-
H
P
N
I
V
A
L
D
D
I
Y
E
S
G
G
H
L
Y
L
I
M
Q
L
V
S
G
G
E
L
F
D
R
I
V
E
K
G
F
Y
T
E
R
D
A
S
R
L
I
F
Q
V
L
D
A
V
K
Y
L
H
D
L
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
Y
S
L
D
E
D
S
K
-
I
M
I
S
D
F
----------------------
V
L
S
-
T
A
C
G
T
P
G
Y
V
A
P
E
V
L
------
A
Q
K
P
Y
-
S
K
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
Y
D
E
N
D
A
K
---
L
F
E
Q
I
L
K
A
E
Y
E
F
D
S
P
Y
W
D
D
I
S
D
S
A
K
D
F
I
R
H
L
M
E
K
D
P
E
K
R
F
T
C
E
Q
A
L
Q
H
P
W
-
I
A---
G
D
T
A
L
D
K
N
I
H
Q
-
S
V
S
E
Q
I
K
K
N
F
A
K
S
K
W
K
Q
A
F
N
A
T
A
V
V
R
----------------------------------------------------------
25
PsiBlast_CBE
80.78
43%
-128
- C1 -
3BHH
1
KCC2B_HUMAN
B:
[2-264]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
T
D
E
Y
Q
L
Y
E
D
I
G
K
---
S
V
V
R
R
C
V
K
L
C
T
G
H
E
Y
A
A
K
I
I
N
T
K
K
L
S
A
R
D
-----
H
--
Q
K
----
L
E
R
-------
E
A
R
I
C
R
L
L
-
K
-
H
S
N
I
V
R
L
H
D
S
I
S
E
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
E
Y
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
A
V
L
H
C
H
Q
M
G
V
V
H
R
D
L
K
P
E
N
L
L
L
A
S
K
C
K
G
A
-
A
V
K
L
A
D
F
G
L
A
-
I
E
-----
V
---
Q
--
G
DQQ
A
W
F
-
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
------
R
K
E
A
Y
-
G
K
P
V
D
I
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
--
W
D
E
D
Q
-
H
K
L
Y
Q
Q
I
K
A
G
A
Y
D
F
P
S
P
E
W
D
T
V
T
P
E
A
K
N
L
I
N
Q
M
L
T
I
N
P
A
K
R
I
T
A
H
E
A
L
K
H
P
W
-
V
----
C
Q
R
S
T
V
A
S
M
M
H
R
Q
E
T
V
E
C
L
K
K
F
N
A
R
R
K
L
K
-------------------------------------------------------------------
23
PsiBlast_CBE
80.23
46%
-108
- C1 -
4FG8
1
KCC1A_HUMAN
B:
[16-298]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
R
D
I
Y
D
F
R
D
V
L
G
T
G
A
F
S
E
V
I
L
A
E
D
K
R
T
Q
K
L
V
A
I
K
C
I
A
K
-----------------------
N
-------
E
I
A
V
L
H
K
I
-
K
-
H
P
N
I
V
A
L
D
D
I
Y
E
S
G
G
H
L
Y
L
I
M
Q
L
V
S
G
G
E
L
F
D
R
I
V
E
K
G
F
Y
T
E
R
D
A
S
R
L
I
F
Q
V
L
D
A
V
K
Y
L
H
D
L
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
Y
S
L
D
E
D
S
K
-
I
M
I
S
D
F
G
---------------G-
S
---
V
L
S
-
T
A
C
G
T
P
G
Y
V
A
P
E
V
L
------
A
Q
K
P
Y
-
S
K
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
Y
D
E
N
D
A
K
---
L
F
E
Q
I
L
K
A
E
Y
E
F
D
S
P
Y
W
D
D
I
S
D
S
A
K
D
F
I
R
H
L
M
E
K
D
P
E
K
R
F
T
C
E
Q
A
L
Q
H
P
W
-
I
A---
G
D
T
A
L
D
K
N
I
H
Q
-
S
V
S
E
Q
I
K
K
N
F
A
-------------------------------------------------------------------------
11
PsiBlast_PDB
80.03
43%
-126
- C1 -
3BHH
1
KCC2B_HUMAN
A:
[1-264]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
---
M
T
D
E
Y
Q
L
Y
E
D
I
G
----
S
V
V
R
R
C
V
K
L
C
T
G
H
E
Y
A
A
K
I
I
N
T
K
K
L
S
A
R
D
-----
H
--
Q
K
----
L
E
R
-------
E
A
R
I
C
R
L
L
-
K
-
H
S
N
I
V
R
L
H
D
S
I
S
E
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
E
Y
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
A
V
L
H
C
H
Q
M
G
V
V
H
R
D
L
K
P
E
N
L
L
L
A
S
K
C
K
G
A
-
A
V
K
L
A
D
F
G
L
A
-
I
E
-----
V
---
Q
--
G
DQQ
A
W
F
-
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
------
R
K
E
A
Y
-
G
K
P
V
D
I
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
--
W
D
E
D
Q
-
H
K
L
Y
Q
Q
I
K
A
G
A
Y
D
F
P
S
P
E
W
D
T
V
T
P
E
A
K
N
L
I
N
Q
M
L
T
I
N
P
A
K
R
I
T
A
H
E
A
L
K
H
P
W
-
V
----
C
Q
R
S
T
V
A
S
M
M
H
R
Q
E
T
V
E
C
L
K
K
F
N
A
R
R
K
L
K
-------------------------------------------------------------------
10
PsiBlast_PDB
79.86
43%
-118
- C1 -
2V7O
3
KCC2G_HUMAN
A:
[20-291]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
Q
S
M
A
T
CTR
F
T
D
D
Y
Q
L
F
E
E
L
G
K
G
-
F
S
V
V
R
R
C
V
K
K
T
P
T
Q
E
Y
A
A
K
I
I
N
T
K
K
L
S
A
R
D
-----
H
--
Q
K----
L
E
R
-------
E
A
R
I
C
R
L
L
-
K
-
H
P
N
I
V
R
L
H
D
S
I
S
E
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
E
Y
Y
S
E
A
D
A
S
H
C
I
H
Q
I
L
E
S
V
N
H
I
H
Q
H
D
I
V
H
R
D
L
K
P
E
N
L
L
L
A
S
K
C
K
G
A
-
A
V
K
L
A
D
F
G
L
A
-
I
E
-----
V
---
Q
--
G
EQQ
A
W
F
-
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
------
R
K
D
P
Y
-
G
K
P
V
D
I
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
--
W
D
E
D
Q
-
H
K
L
Y
Q
Q
I
K
A
G
A
Y
D
F
P
S
P
E
W
D
T
V
T
P
E
A
K
N
L
I
N
Q
M
L
T
I
N
P
A
K
R
I
T
A
D
Q
A
L
K
H
P
W
-
V
----
C
Q
R
S
T
V
A
S
M
M
H
R
Q
E
T
V
E
C
L
R
K
F
N
A
R
R
K
L
K
G
------------------------------------------------------------------
7
PsiBlast_PDB
79.30
46%
-122
- C1 -
4FG7
1
KCC1A_HUMAN
A:
[16-277]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
R
D
I
Y
D
F
R
D
V
L
G
T
G
A
F
S
E
V
I
L
A
E
D
K
R
T
Q
K
L
V
A
I
K
C
I
A
----------------
S
-----
M
E
N
-------
E
I
A
V
L
H
K
I
-
K
-
H
P
N
I
V
A
L
D
D
I
Y
E
S
G
G
H
L
Y
L
I
M
Q
L
V
S
G
G
E
L
F
D
R
I
V
E
K
G
F
Y
T
E
R
D
A
S
R
L
I
F
Q
V
L
D
A
V
K
Y
L
H
D
L
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
Y
S
L
D
E
D
S
K
-
I
M
I
S
D
F
G
L
S
-
K
M
-----
E
---
D
PG------------
T
P
G
Y
V
A
P
E
V
L
------
A
Q
K
---
S
K
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
Y
D
E
N
D
A
K
---
L
F
E
Q
I
L
K
A
E
Y
E
F
D
S
P
Y
W
D
D
I
S
D
S
A
K
D
F
I
R
H
L
M
E
K
D
P
E
K
R
F
T
C
E
Q
A
L
Q
H
P
W
-
I
A---------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
78.40
42%
-121
- C1 -
2WEL
7
KCC2D_HUMAN
A:
[1-264]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
---
M
T
D
E
Y
Q
L
F
E
E
L
G
K
G
A
F
S
V
V
R
R
C
M
K
I
P
T
G
Q
E
Y
A
A
K
I
I
N
T
K
K
L
S
A
R
D
-----
H
--
Q
K
----
L
E
R
-------
E
A
R
I
C
R
L
L
-
K
-
H
P
N
I
V
R
L
H
D
S
I
S
E
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
E
Y
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
L
N
G
I
V
H
R
D
L
K
P
E
N
L
L
L
A
S
K
S
K
G
A
-
A
V
K
L
A
D
F
G
L
A
-
I
E
-----
V
---
Q
--
G
DQQ
A
W
F
-
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
------
R
K
D
P
Y
-
G
K
P
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
--
D
E
D
Q
-
H
R
L
Y
Q
Q
I
K
A
G
A
Y
D
F
P
S
P
E
W
D
T
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
A
K
R
I
T
A
S
E
A
L
K
H
P
W
-
I
----
C
Q
R
S
M
M
H
R
Q
E
T
V
D
C
L
K
K
F
N
A
R
R
K
L
K
G
A
I
L
T
T
M
L
A
T
R
N
F
S
A
--------------------------------------------------------
2
PsiBlast_PDB
78.18
44%
-107
- C1 -
2JC6
1
KCC1D_HUMAN
A:
[20-302]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
K
K
I
F
E
F
K
E
T
L
G
T
G
A
F
S
E
V
V
L
A
E
E
K
A
T
G
K
L
F
A
V
K
C
I
P
K
K
A
----------
S
--
S
-----
I
E
N
-------
E
I
A
V
L
R
K
I
-
K
-
H
E
N
I
V
A
L
E
D
I
Y
E
S
P
N
H
L
Y
L
V
M
Q
L
V
S
G
G
E
L
F
D
R
I
V
E
K
G
F
Y
T
E
K
D
A
S
T
L
I
R
Q
V
L
D
A
V
Y
Y
L
H
R
M
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
Y
S
-
Q
D
E
E
S
K
I
M
I
S
---------------------------------
P
G
Y
V
A
P
E
V
L
------
A
Q
K
P
Y
-
S
K
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
Y
D
E
N
D
S
K
---
L
F
E
Q
I
L
K
A
E
Y
E
F
D
S
P
Y
W
D
D
I
S
D
S
A
K
D
F
I
R
N
L
M
E
K
D
P
N
K
R
Y
T
C
E
Q
A
A
R
H
P
W
-
I
A---
G
D
T
A
L
N
K
N
I
H
E
-
S
V
S
A
Q
I
R
K
N
F
A
K
S
K
W
R
Q
A
F
N
A
T
--------------------------------------------------------------
21
PsiBlast_CBE
77.85
44%
-109
- C1 -
2JC6
1
KCC1D_HUMAN
C:
[20-302]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
K
K
I
F
E
F
K
E
T
L
G
T
G
A
F
S
E
V
V
L
A
E
E
K
A
T
G
K
L
F
A
V
K
C
I
P
K
K
A
-------------
S
-----
I
E
N
-------
E
I
A
V
L
R
K
I
-
K
-
H
E
N
I
V
A
L
E
D
I
Y
E
S
P
N
H
L
Y
L
V
M
Q
L
V
S
G
G
E
L
F
D
R
I
V
E
K
G
F
Y
T
E
K
D
A
S
T
L
I
R
Q
V
L
D
A
V
Y
Y
L
H
R
M
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
Y
S
-
Q
D
E
E
S
K
I
M
I
S
---------------------------------
P
G
Y
V
A
P
E
V
L
------
A
Q
K
P
Y
-
S
K
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
Y
D
E
N
D
S
K
---
L
F
E
Q
I
L
K
A
E
Y
E
F
D
S
P
Y
W
D
D
I
S
D
S
A
K
D
F
I
R
N
L
M
E
K
D
P
N
K
R
Y
T
C
E
Q
A
A
R
H
P
W
-
I
A---
G
D
T
A
L
N
K
N
I
H
E
-
S
V
S
A
Q
I
R
K
N
F
A
K
S
K
W
R
Q
A
F
N
A
T
--------------------------------------------------------------
27
PsiBlast_CBE
77.24
42%
-121
- C1 -
2VN9
1
KCC2D_HUMAN
B:
[1-264]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
---
M
T
D
E
Y
Q
L
F
E
E
L
G
K
G
A
F
S
V
V
R
R
C
M
K
I
P
T
G
Q
E
Y
A
A
K
I
I
N
T
K
K
L
S
A
R
D
-----
H
--
Q
K----
L
E
R
-------
E
A
R
I
C
R
L
L
-
K
-
H
P
N
I
V
R
L
H
D
S
I
S
E
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
E
Y
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
L
N
G
I
V
H
R
D
L
K
P
E
N
L
L
L
A
S
K
S
K
G
A
-
A
V
K
L
A
D
F
G
L
A
-
I
E
-----
V
---
Q
--
G
DQQ
A
W
F
-
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
------
R
K
D
P
Y
-
G
K
P
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
--
W
D
E
D
Q
-
H
R
L
Y
Q
Q
I
K
A
G
A
Y
D
F
P
S
P
E
W
D
T
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
A
K
R
I
T
A
S
E
A
L
K
H
P
W
-
I
----
C
Q
R
S
T
V
A
S
M
M
H
R
Q
E
T
V
D
C
L
K
K
F
N
A
R
R
K
L
K
G
A
I
L
T
T
M
L
-----------------------------------------------------------
15
PsiBlast_PDB
76.72
42%
-121
- C1 -
2VN9
2
KCC2D_HUMAN
A:
[1-264]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
---
M
T
D
E
Y
Q
L
F
E
E
L
G
K
G
A
F
S
V
V
R
R
C
M
K
I
P
T
G
Q
E
Y
A
A
K
I
I
N
T
K
K
L
S
A
R
D
-----
H
--
Q
K
----
L
E
R
-------
E
A
R
I
C
R
L
L
-
K
-
H
P
N
I
V
R
L
H
D
S
I
S
E
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
E
Y
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
L
N
G
I
V
H
R
D
L
K
P
E
N
L
L
L
A
S
K
S
K
G
A
-
A
V
K
L
A
D
F
G
L
A
-
I
E
-----
V
---
Q
--
G
DQQ
A
W
F
-
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
------
R
K
D
P
Y
-
G
K
P
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
--
W
D
E
D
Q
-
H
R
L
Y
Q
Q
I
K
A
G
A
Y
D
F
P
S
P
E
W
D
T
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
A
K
R
I
T
A
S
E
A
L
K
H
P
W
-
I
----
C
Q
R
S
T
V
A
S
M
M
H
R
Q
E
T
V
D
C
L
K
K
F
N
A
R
R
K
L
K
G
A
I
L
T
T
M
L
-----------------------------------------------------------
52
PsiBlast_CBE
75.22
37%
-113
- C1 -
2Y0A
1
DAPK1_HUMAN
A:
[8-275]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
---
V
D
D
Y
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
R
T
K
S
S
R
-----
R
--
G
VS
R
E
D
I
E
R
-------
E
V
S
I
L
K
E
I
-
Q
-
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
E
S
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
R
I
K
I
I
D
F
G
L
A
-
H
K
-----
I
---
D
FG
N
---
E
F
K
-
N
I
F
G
T
P
E
F
V
A
P
E
I
V
------
N
Y
E
P
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
--
G
D
T
K
-
Q
E
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
-
I
----
K
P
K
D
T
Q
Q
A
L
S
R
K
A
S
A
V
N
M
E
K
F
K
K
F
A
A
R
---------------------------------------------------------------------
100
PsiBlast_CBE
75.01
35%
-112
- C1 -
2Y7J
1
PHKG2_HUMAN
D:
[82-362]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
D
--
W
A
A
A
K
E
---
F
Y
Q
K
Y
D
P
K
D
V
I
G
R
G
V
S
S
V
V
R
R
C
V
H
R
A
T
G
H
E
F
A
V
K
I
M
E
V
---
R
L
S
P
-----
E
--
Q
-----
L
E
E
VREATRR
E
T
H
I
L
R
Q
V
-
A
G
H
P
H
I
I
T
L
I
D
S
Y
E
S
S
S
F
M
F
L
V
F
D
L
M
R
K
G
E
L
F
D
Y
L
T
E
K
V
A
L
S
E
K
E
T
R
S
I
M
R
S
L
L
E
A
V
S
F
L
H
A
N
N
I
V
H
R
D
L
K
P
E
N
I
L
L
----
D
D
N
M
Q
I
R
L
S
D
F
G
F
S
-
C
H
-----
L
---
E
PG
E
---
K
L
R
-
E
L
C
G
T
P
G
Y
L
A
P
E
I
L
KCSMDE
T
H
P
G
Y
-
G
K
E
V
D
L
W
A
C
G
V
I
L
F
T
L
L
A
G
S
P
P
F
W
H
R
--
R
Q
-
I
L
M
L
R
M
I
M
E
G
Q
Y
Q
F
S
S
P
E
W
D
D
R
S
S
T
V
K
D
L
I
S
R
L
L
Q
V
D
P
E
A
R
L
T
A
E
Q
A
L
Q
H
P
F
-
F
----
E
R
----------------------------------------------------------------------------------------------
101
PsiBlast_CBE
74.84
35%
-112
- C1 -
2Y7J
1
PHKG2_HUMAN
C:
[82-362]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
D
--
W
A
A
A
K
E
---
F
Y
Q
K
Y
D
P
K
D
V
I
G
R
G
V
S
S
V
V
R
R
C
V
H
R
A
T
G
H
E
F
A
V
K
I
M
E
V
T
A
E
R
L
S
P
-----
E
--
Q
-----
L
E
E
VREATRR
E
T
H
I
L
R
Q
V
-
A
G
H
P
H
I
I
T
L
I
D
S
Y
E
S
S
S
F
M
F
L
V
F
D
L
M
R
K
G
E
L
F
D
Y
L
T
E
K
V
A
L
S
E
K
E
T
R
S
I
M
R
S
L
L
E
A
V
S
F
L
H
A
N
N
I
V
H
R
D
L
K
P
E
N
I
L
L
----
D
D
N
M
Q
I
R
L
S
D
F
G
F
S
-
C
H
-----
L
---
E
PG
E
---
K
L
R
-
E
L
C
G
T
P
G
Y
L
A
P
E
I
L
KCSMDE
T
H
P
G
Y
-
G
K
E
V
D
L
W
A
C
G
V
I
L
F
T
L
L
A
G
S
P
P
F
W
H
R
--
R
Q
-
I
L
M
L
R
M
I
M
E
G
Q
Y
Q
F
S
S
P
E
W
D
D
R
S
S
T
V
K
D
L
I
S
R
L
L
Q
V
D
P
E
A
R
L
T
A
E
Q
A
L
Q
H
P
F
-
F
----
E
R
----------------------------------------------------------------------------------------------
24
PsiBlast_CBE
74.74
42%
-101
- C1 -
2JAM
3
KCC1G_HUMAN
B:
[7-287]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
R
K
T
F
I
F
M
E
V
L
G
S
G
A
F
S
E
V
F
L
V
K
Q
R
L
T
G
K
L
F
A
L
K
C
I
K
K
S
--------------
S
-----
L
E
N
-------
E
I
A
V
L
K
K
I
-
K
-
H
E
N
I
V
T
L
E
D
I
Y
E
S
T
T
H
Y
Y
L
V
M
Q
L
V
S
G
G
E
L
F
D
R
I
L
E
R
G
V
Y
T
E
K
D
A
S
L
V
I
Q
Q
V
L
S
A
V
K
Y
L
H
E
N
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
L
T
P
E
E
N
S
K
-
I
M
I
T
D
F
G
L
S
-
K
M
E----
Q
---
N
--
G
---
I
M
S
-
T
A
C
G
T
P
G
Y
V
A
P
E
V
L
------
A
Q
K
P
Y
-
S
K
A
V
D
C
W
S
I
G
V
I
T
Y
I
L
L
C
G
Y
P
P
F
Y
E
E
T
E
S
K
---
L
F
E
K
I
K
E
G
Y
Y
E
F
E
S
P
F
W
D
D
I
S
E
S
A
K
D
F
I
C
H
L
L
E
K
D
P
N
E
R
Y
T
C
E
K
A
L
S
H
P
W
-
I
----
D
G
N
T
A
L
H
R
D
I
Y
P
S
V
S
L
Q
I
Q
K
N
F
A
K
------------------------------------------------------------------------
102
PsiBlast_CBE
74.69
35%
-113
- C1 -
2Y7J
1
PHKG2_HUMAN
A:
[82-362]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
D
--
W
A
A
A
K
E
---
F
Y
Q
K
Y
D
P
K
D
V
I
G
R
G
V
S
S
V
V
R
R
C
V
H
R
A
T
G
H
E
F
A
V
K
I
M
E
V
T
A
E
R
L
S
P
-----
E
--
Q
-----
L
E
E
V
R
E
A
T
R
R
E
T
H
I
L
R
Q
V
-
A
G
H
P
H
I
I
T
L
I
D
S
Y
E
S
S
S
F
M
F
L
V
F
D
L
M
R
K
G
E
L
F
D
Y
L
T
E
K
V
A
L
S
E
K
E
T
R
S
I
M
R
S
L
L
E
A
V
S
F
L
H
A
N
N
I
V
H
R
D
L
K
P
E
N
I
L
L
----
D
D
N
M
Q
I
R
L
S
D
F
G
F
S
-
C
H
-----
L
---
E
P
G
E
---
K
L
R
-
E
L
C
G
T
P
G
Y
L
A
P
E
I
L
K
C
S
M
D
E
T
H
P
G
Y
-
G
K
E
V
D
L
W
A
C
G
V
I
L
F
T
L
L
A
G
S
P
P
F
W
H
R
--
R
Q
-
I
L
M
L
R
M
I
M
E
G
Q
Y
Q
F
S
S
P
E
W
D
D
R
S
S
T
V
K
D
L
I
S
R
L
L
Q
V
D
P
E
A
R
L
T
A
E
Q
A
L
Q
H
P
F
-
F
----
E
R
----------------------------------------------------------------------------------------------
79
PsiBlast_CBE
74.67
37%
-108
- C1 -
1WVY
1
DAPK1_HUMAN
A:
[9-275]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
D
D
Y
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
R
T
K
S
S
R
-----
R
--
G
VS
R
E
D
I
E
R
-------
E
V
S
I
L
K
E
I
-
Q
-
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
E
S
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
R
I
K
I
I
D
F
G
L
A
-
H
K
-----
I
---
D
F
G
N
---
E
F
K
-
N
I
F
G
T
P
E
F
V
A
P
E
I
V
------
N
Y
E
P
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
--
G
D
T
K
-
Q
E
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
-
I
----
K
-----------------------------------------------------------------------------------------------
50
PsiBlast_CBE
74.65
37%
-110
- C1 -
2W4K
1
DAPK1_HUMAN
A:
[9-275]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
D
D
Y
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
R
T
K
S
S
R
-----
R
--
G
VS
R
E
D
I
E
R
-------
E
V
S
I
L
K
E
I
-
Q
-
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
E
S
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
R
I
K
I
I
D
F
G
L
A
-
H
K
-----
I
---
D
FG
N
---
E
F
K
-
N
I
F
G
T
P
E
F
V
A
P
E
I
V
------
N
Y
E
P
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
--
G
D
T
K
-
Q
E
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
-
I
----
K
P
K
D
T
Q
Q
A
L
S
R
K
A
S
A
V
N
M
E
K
F
K
K
F
A
A
R
---------------------------------------------------------------------
73
PsiBlast_CBE
74.39
37%
-110
- C1 -
4TXC
7
DAPK1_HUMAN
A:
[28-294]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
D
D
Y
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
R
T
K
S
S
R
-----
R
--
G
VS
R
E
D
I
E
R
-------
E
V
S
I
L
K
E
I
-
Q
-
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
E
S
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
R
I
K
I
I
D
F
G
L
A
-
H
K
-----
I
---
D
FG
N
---
E
F
K
-
N
I
F
G
T
P
E
F
V
A
P
E
I
V
------
N
Y
E
P
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
--
G
D
T
K
-
Q
E
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
-
I
----
K
P
----------------------------------------------------------------------------------------------
9
PsiBlast_PDB
74.03
42%
-99
- C1 -
2JAM
3
KCC1G_HUMAN
A:
[7-287]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
R
K
T
F
I
F
M
E
V
L
G
S
G
A
F
S
E
V
F
L
V
K
Q
R
L
T
G
K
L
F
A
L
K
C
I
K
K
S
--------------
S
-----
L
E
N
-------
E
I
A
V
L
K
K
I
-
K
-
H
E
N
I
V
T
L
E
D
I
Y
E
S
T
T
H
Y
Y
L
V
M
Q
L
V
S
G
G
E
L
F
D
R
I
L
E
R
G
V
Y
T
E
K
D
A
S
L
V
I
Q
Q
V
L
S
A
V
K
Y
L
H
E
N
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
L
T
P
E
E
N
S
K
-
I
M
I
T
D
F
G
L
S
-
K
M
E
----
Q
---
N
--
G
---
I
M
S
-
T
A
C
G
T
P
G
Y
V
A
P
E
V
L
------
A
Q
K
P
Y
-
S
K
A
V
D
C
W
S
I
G
V
I
T
Y
I
L
L
C
G
Y
P
P
F
Y
E
E
T
E
S
K
---
L
F
E
K
I
K
E
G
Y
Y
E
F
E
S
P
F
W
D
D
I
S
E
S
A
K
D
F
I
C
H
L
L
E
K
D
P
N
E
R
Y
T
C
E
K
A
L
S
H
P
W
-
I
----
D
G
N
T
A
L
H
R
D
I
Y
P
S
V
S
L
Q
I
Q
K
N
F
A
K
S
-----------------------------------------------------------------------
72
PsiBlast_CBE
73.93
37%
-109
- C1 -
2YAK
1
DAPK1_HUMAN
A:
[9-275]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
D
D
Y
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
R
T
K
S
S
R
-----
R
--
G
VS
R
E
D
I
E
R
-------
E
V
S
I
L
K
E
I
-
Q
-
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
E
S
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
R
I
K
I
I
D
F
G
L
A
-
H
K
-----
I
---
D
FG
N
---
E
F
K
-
N
I
F
G
T
P
E
F
V
A
P
E
I
V
------
N
Y
E
P
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
--
G
D
T
K
-
Q
E
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
-
I
----
K
P
K
---------------------------------------------------------------------------------------------
87
PsiBlast_CBE
73.49
37%
-111
- C1 -
3GU8
1
DAPK1_HUMAN
A:
[9-275]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
D
D
Y
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
R
T
K
S
S
R
-----
R
--
G
VS
R
E
D
I
E
R
-------
E
V
S
I
L
K
E
I
-
Q
-
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
G
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
E
S
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
R
I
K
I
I
D
F
G
L
A
-
H
K
-----
I
---
D
FG
N
---
E
F
K
-
N
I
F
G
T
P
E
F
V
A
P
E
I
V
------
N
Y
E
P
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
--
G
D
T
K
-
Q
E
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
-
I
----
K
P
Q
F
--------------------------------------------------------------------------------------------
83
PsiBlast_CBE
73.30
37%
-110
- C1 -
3GU6
1
DAPK1_HUMAN
A:
[9-275]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
D
D
Y
Y
D
T
G
E
E
L
G
S
G
V
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
R
T
K
S
S
R
-----
R
--
G
VS
R
E
D
I
E
R
-------
E
V
S
I
L
K
E
I
-
Q
-
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
E
S
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
R
I
K
I
I
D
F
G
L
A
-
H
K
-----
I
---
D
FG
N
---
E
F
K
-
N
I
F
G
T
P
E
F
V
A
P
E
I
V
------
N
Y
E
P
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
--
G
D
T
K
-
Q
E
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
-
I
----
K
P
P
Q
F
E
------------------------------------------------------------------------------------------
81
PsiBlast_CBE
73.15
37%
-110
- C1 -
2W4J
1
DAPK1_HUMAN
A:
[9-275]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
D
D
Y
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
R
T
K
S
S
R
-----
R
--
G
VS
R
E
D
I
E
R
-------
E
V
S
I
L
K
E
I
-
Q
-
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
E
S
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
R
I
K
I
I
D
F
G
L
A
-
H
K
-----
I
---
D
FG
N
---
E
F
K
-
N
I
F
G
T
P
E
F
V
A
P
E
I
V
------
N
Y
E
P
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
--
G
D
T
K
-
Q
E
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
-
I
----
K
P
----------------------------------------------------------------------------------------------
82
PsiBlast_CBE
73.13
37%
-110
- C1 -
3GU7
1
DAPK1_HUMAN
A:
[9-275]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
D
D
Y
Y
D
T
G
E
E
L
G
S
G
V
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
R
T
K
S
S
R
-----
R
--
G
VS
R
E
D
I
E
R
-------
E
V
S
I
L
K
E
I
-
Q
-
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
E
S
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
R
I
K
I
I
D
F
G
L
A
-
H
K
-----
I
---
D
FG
N
---
E
F
K
-
N
I
F
G
T
P
E
F
V
A
P
E
I
V
------
N
Y
E
P
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
--
G
D
T
K
-
Q
E
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
-
I
----
K
P
P
Q
F
E
------------------------------------------------------------------------------------------
57
PsiBlast_CBE
73.08
37%
-111
- C1 -
3EH9
1
DAPK1_HUMAN
A:
[8-274]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
D
D
Y
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
R
T
K
S
S
R
--------
G
VS
R
E
D
I
E
R
-------
E
V
S
I
L
K
E
I
-
Q
-
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
-
S
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
R
I
K
I
I
D
F
G
L
A
-
H
K
-----
I
---
D
FG
N
---
E
F
K
-
N
I
F
G
T
P
E
F
V
A
P
E
I
V
------
N
Y
E
P
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
--
G
D
T
K
-
Q
E
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
-
I
----
K
P
P
Q
F
E
------------------------------------------------------------------------------------------
67
PsiBlast_CBE
73.07
37%
-111
- C1 -
3DFC
1
DAPK1_HUMAN
B:
[9-275]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
D
D
Y
Y
D
T
G
E
E
L
G
S
G
K
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
R
T
K
S
S
R
-----
R
--
G
VSRED
I
E
R
-------
E
V
S
I
L
K
E
I
-
Q
-
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
E
S
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
R
I
K
I
I
D
F
G
L
A
-
H
K
-----
I
---
D
FG
N
---
E
F
K
-
N
I
F
G
T
P
E
F
V
A
P
E
I
V
------
N
Y
E
P
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
--
G
D
T
K
-
Q
E
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
-
I
----
K
P
P
Q
F
E
------------------------------------------------------------------------------------------
60
PsiBlast_CBE
73.04
37%
-108
- C1 -
1IG1
1
DAPK1_HUMAN
A:
[8-274]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
D
D
Y
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
R
T
K
S
S
R
-----
R
--
G
VS
R
E
D
I
E
R
-------
E
V
S
I
L
K
E
I
-
Q
-
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
E
S
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
R
I
K
I
I
D
F
G
L
A
-
H
K
-----
I
---
D
FG
N
---
E
F
K
-
N
I
F
G
T
P
E
F
V
A
P
E
I
V
------
N
Y
E
P
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
--
G
D
T
K
-
Q
E
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
-
I
----
K
P
P
Q
F
E
------------------------------------------------------------------------------------------
46
PsiBlast_CBE
73.00
37%
-108
- C1 -
4B4L
3
DAPK1_HUMAN
A:
[11-277]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
D
D
Y
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
R
T
K
S
S
R
-----
R
--
G
VS
R
E
D
I
E
R
-------
E
V
S
I
L
K
E
I
-
Q
-
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
E
S
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
R
I
K
I
I
D
F
G
L
A
-
H
K
-----
I
---
D
FG
N
---
E
F
K
-
N
I
F
G
T
P
E
F
V
A
P
E
I
V
------
N
Y
E
P
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
--
G
D
T
K
-
Q
E
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
-
I
----
K
P
K
D
T
Q
Q
A
L
S
R
K
A
S
A
V
N
M
E
K
F
K
K
F
A
A
A
K
--------------------------------------------------------------------
54
PsiBlast_CBE
72.89
37%
-108
- C1 -
4YO4
1
DAPK1_HUMAN
A:
[8-274]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
D
D
Y
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
R
T
K
S
S
R
-----
R
--
G
VS
R
E
D
I
E
R
-------
E
V
S
I
L
K
E
I
-
Q
-
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
E
S
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
R
I
K
I
I
D
F
G
L
A
-
H
K
-----
I
---
D
FG
N
---
E
F
K
-
N
I
F
G
T
P
E
F
V
A
P
E
I
V
------
N
Y
E
P
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
--
G
D
T
K
-
Q
E
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
-
I
----
K
P
Q
F
E
K
------------------------------------------------------------------------------------------
56
PsiBlast_CBE
72.85
37%
-112
- C1 -
3EHA
1
DAPK1_HUMAN
A:
[8-274]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
D
D
Y
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
R
T
K
S
S
R
-----
R
--
G
VS
R
E
D
I
E
R
-------
E
V
S
I
L
K
E
I
-
Q
-
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
-
S
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
R
I
K
I
I
D
F
G
L
A
-
H
K
-----
I
---
D
FG
N
---
E
F
K
-
N
I
F
G
T
P
E
F
V
A
P
E
I
V
------
N
Y
E
P
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
--
G
D
T
K
-
Q
E
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
-
I
----
K
P
P
Q
F
E
------------------------------------------------------------------------------------------
86
PsiBlast_CBE
72.72
37%
-111
- C1 -
3GUB
1
DAPK1_HUMAN
A:
[9-275]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
D
D
Y
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
R
T
K
S
S
R
-----
R
--
G
VS
R
E
D
I
E
R
-------
E
V
S
I
L
K
E
I
-
Q
-
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
G
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
E
S
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
R
I
K
I
I
D
F
G
L
A
-
H
K
-----
I
---
D
FG
N
---
E
F
K
-
N
I
F
G
T
P
E
F
V
A
P
E
I
V
------
N
Y
E
P
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
--
G
D
T
K
-
Q
E
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
-
I
----
K
P
Q
F
--------------------------------------------------------------------------------------------
53
PsiBlast_CBE
72.45
37%
-109
- C1 -
4YPD
1
DAPK1_HUMAN
A:
[8-274]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
D
D
Y
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
R
T
K
S
S
R
-----
R
--
G
VS
R
E
D
I
E
R
-------
E
V
S
I
L
K
E
I
-
Q
-
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
E
S
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
R
I
K
I
I
D
F
G
L
A
-
H
K
-----
I
---
D
FG
N
---
E
F
K
-
N
I
F
G
T
P
E
F
V
A
P
E
I
V
------
N
Y
E
P
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
--
G
D
T
K
-
Q
E
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
-
I
----
K
P
P
Q
F
E
K
-----------------------------------------------------------------------------------------
75
PsiBlast_CBE
72.44
38%
-114
- C1 -
2YAA
1
DAPK2_MOUSE
B:
[14-276]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
D
I
G
E
E
L
G
S
G
Q
F
A
I
V
K
K
C
R
E
K
S
T
G
L
E
Y
A
A
K
F
I
K
K
R
Q
S
R
A
S
R
RGVC
R
E
--
E
-----
I
E
R
-------
E
V
S
I
L
R
Q
V
-
L
-
H
P
N
I
I
T
L
H
D
V
Y
E
N
R
T
D
V
V
L
I
L
E
L
V
S
G
G
E
L
F
D
F
L
A
Q
K
E
S
L
S
E
E
E
A
T
S
F
I
K
Q
I
L
D
G
V
N
Y
L
H
T
K
K
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
K
N
I
P
I
P
H
I
K
L
I
D
F
G
L
A
H
E
I
-----
E
---
D
--
G
---
V
E
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
------
N
Y
E
P
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
--
L
G
D
T
K
-
Q
E
T
L
A
N
I
T
A
V
S
Y
D
F
D
E
E
F
F
S
Q
T
S
E
L
A
K
D
F
I
R
K
L
L
V
K
E
T
R
K
R
L
T
I
Q
E
A
L
R
H
P
W
-
I
----
T
P
V
D
T
Q
Q
A
M
V
R
R
E
S
V
V
N
L
E
N
F
K
K
Q
Y
V
----------------------------------------------------------------------
61
PsiBlast_CBE
72.43
37%
-113
- C1 -
1P4F
1
DAPK1_HUMAN
A:
[8-274]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
D
D
Y
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
R
T
K
S
S
R
-----
R
--
G
VS
R
E
D
I
E
R
-------
E
V
S
I
L
K
E
I
-
Q
-
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
-------
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
--
R
I
K
I
I
D
F
G
L
A
-
H
K
-----
I
---
D
FG
N
---
E
F
K
-
N
I
F
G
T
P
E
F
V
A
P
E
I
V
------
N
Y
E
P
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
--
G
D
T
K
-
Q
E
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
-
I
----
K
P
Q
F
--------------------------------------------------------------------------------------------
59
PsiBlast_CBE
72.30
37%
-107
- C1 -
1JKK
1
DAPK1_HUMAN
A:
[8-274]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
D
D
Y
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
R
T
K
S
S
R
-----
R
--
G
VS
R
E
D
I
E
R
-------
E
V
S
I
L
K
E
I
-
Q
-
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
E
S
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
R
I
K
I
I
D
F
G
L
A
-
H
K
-----
I
---
D
FG
N
---
E
F
K
-
N
I
F
G
T
P
E
F
V
A
P
E
I
V
------
N
Y
E
P
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
--
G
D
T
K
-
Q
E
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
-
I
----
K
P
F
---------------------------------------------------------------------------------------------
84
PsiBlast_CBE
72.28
37%
-110
- C1 -
3GU5
1
DAPK1_HUMAN
A:
[9-275]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
D
D
Y
Y
D
T
G
E
E
L
G
S
G
V
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
R
T
K
S
S
R
-----
R
--
G
VS
R
E
D
I
E
R
-------
E
V
S
I
L
K
E
I
-
Q
-
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
E
S
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
R
I
K
I
I
D
F
G
L
A
-
H
K
-----
I
---
D
FG
N
---
E
F
K
-
N
I
F
G
T
P
E
F
V
A
P
E
I
V
------
N
Y
E
P
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
--
G
D
T
K
-
Q
E
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
-
I
----
K
P
P
Q
F
E
------------------------------------------------------------------------------------------
85
PsiBlast_CBE
72.23
37%
-107
- C1 -
3GU4
1
DAPK1_HUMAN
A:
[9-275]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
D
D
Y
Y
D
T
G
E
E
L
G
S
G
V
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
R
T
K
S
S
R
-----
R
--
G
VS
R
E
D
I
E
R
-------
E
V
S
I
L
K
E
I
-
Q
-
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
E
S
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
R
I
K
I
I
D
F
G
L
A
-
H
K
-----
I
---
D
FG
N
---
E
F
K
-
N
I
F
G
T
P
E
F
V
A
P
E
I
V
------
N
Y
E
P
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
--
G
D
T
K
-
Q
E
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
-
I
----
K
P
P
Q
F
E
------------------------------------------------------------------------------------------
44
PsiBlast_CBE
72.15
37%
-89
- C1 -
3HZT
9
?
A:
[3-325]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
D
R
Y
Q
R
V
K
K
L
G
S
G
A
Y
G
E
V
L
L
C
K
D
K
L
T
G
A
E
R
A
I
K
I
I
K
K
S
S
V
T
T
T
S
-----
N
S
G
A
-----
L
L
D
-------
E
V
A
V
L
K
Q
L
-
D
-
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
R
N
Y
Y
L
V
M
E
V
Y
R
G
G
E
L
F
D
E
I
I
L
R
Q
K
F
S
E
V
D
A
A
V
I
M
K
Q
V
L
S
G
T
T
Y
L
H
K
H
N
I
V
H
R
D
L
K
P
E
N
L
L
L
-
E
S
K
S
R
D
A
L
I
K
I
V
D
F
G
L
S
-
A
H
FE---
V
---
G
--------------
T
A
Y
Y
I
A
P
E
V
L
------
R
K
K
-
Y
-
D
E
K
C
D
V
W
S
C
G
V
I
L
Y
I
L
L
C
G
Y
P
P
F
-
G
G
Q
T
D
Q
-
E
I
L
-
K
R
V
E
K
G
K
F
S
F
D
P
P
D
W
T
Q
V
S
D
E
A
K
Q
L
V
K
L
M
L
T
Y
E
P
S
K
R
I
S
A
E
E
A
L
N
H
P
W
-
I
V
K
F
C
S
Q
----
V
G
K
H
A
L
T
G
A
L
G
N
M
K
K
F
Q
S
S
Q
K
L
A
Q
A
A
M
L
F
M
G
S
K
L
T
T
L
E
E
T
K
E
L
T
Q
I
F
R
Q
L
D
N
N
G
D
G
Q
L
D
R
K
E
L
I
E
G
Y
R
K
L
M
Q
W
S
S
Q
I
E
A
E
V
D
H
I
L
Q
S
V
D
F
47
PsiBlast_CBE
72.14
37%
-110
- C1 -
2XUU
1
DAPK1_HUMAN
A:
[9-275]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
D
D
Y
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
R
T
K
S
S
R
-----
R
--
G
VS
R
E
D
I
E
R
-------
E
V
S
I
L
K
E
I
-
Q
-
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
E
S
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
R
I
K
I
I
D
F
G
L
A
-
H
K
-----
I
---
D
FG
N
---
E
F
K
-
N
I
F
G
T
P
A
F
V
A
P
E
I
V
------
N
Y
E
P
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
--
G
D
T
K
-
Q
E
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
-
I
----
K
P
K
D
T
Q
Q
A
L
S
R
K
A
S
A
V
N
M
E
K
F
K
K
F
A
A
R
---------------------------------------------------------------------
66
PsiBlast_CBE
72.12
37%
-110
- C1 -
3F5U
1
DAPK1_HUMAN
A:
[9-275]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
D
D
Y
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
R
T
K
S
S
R
-----
R
--
G
VS
R
E
D
I
E
R
-------
E
V
S
I
L
K
E
I
-
Q
-
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
E
S
L
T
E
E
E
A
T
E
F
-
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
R
I
K
I
I
D
F
G
L
A
-
H
K
-----
I
---
D
FG
N
---
E
F
K
-
N
I
F
G
T
P
E
F
V
A
P
E
I
V
------
N
Y
E
P
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
--
G
D
T
K
-
Q
E
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
-
I
----
K
P
P
Q
F
E
------------------------------------------------------------------------------------------
109
PsiBlast_CBE
71.94
38%
-115
- C1 -
2CKE
1
DAPK2_HUMAN
B:
[14-276]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
D
I
G
E
E
L
G
S
G
Q
F
A
I
V
K
K
C
R
E
K
S
T
G
L
E
Y
A
A
K
F
I
K
K
R
Q
S
R
A
S
R
R
G
V
S
R
E
--
E
-----
I
E
R
-------
E
V
S
I
L
R
Q
V
-
L
-
H
H
N
V
I
T
L
H
D
V
Y
E
N
R
T
D
V
V
L
I
L
E
L
V
S
G
G
E
L
F
D
F
L
A
Q
K
E
S
L
S
E
E
E
A
T
S
F
I
K
Q
I
L
D
G
V
N
Y
L
H
T
K
K
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
K
N
I
P
I
P
H
I
K
L
I
D
F
G
L
A
H
E
I
-----
E
---
D
--
G
---
V
E
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
------
N
Y
E
P
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
--
L
G
D
T
K
-
Q
E
T
L
A
N
I
T
S
V
S
Y
D
F
D
E
E
F
F
S
H
T
S
E
L
A
K
D
F
I
R
K
L
L
V
K
E
T
R
K
R
L
T
I
Q
E
A
L
R
H
P
W
-
I
----
T
P
V
D
N
Q
Q
A
M
V
R
R
E
S
V
V
N
L
E
N
F
R
K
Q
Y
V
----------------------------------------------------------------------
58
PsiBlast_CBE
71.89
37%
-109
- C1 -
1JKL
1
DAPK1_HUMAN
A:
[8-274]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
D
D
Y
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
R
T
K
S
S
R
-----
R
--
G
VS
R
E
D
I
E
R
-------
E
V
S
I
L
K
E
I
-
Q
-
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
E
S
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
R
I
K
I
I
D
F
G
L
A
-
H
K
-----
I
---
D
FG
N
---
E
F
K
-
N
I
F
G
T
P
E
F
V
A
P
E
I
V
------
N
Y
E
P
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
--
G
D
T
K
-
Q
E
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
-
I
----
K
P
P
Q
F
E
------------------------------------------------------------------------------------------
65
PsiBlast_CBE
71.86
37%
-111
- C1 -
4UV0
1
?
A:
[11-277]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
D
D
Y
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
R
T
K
S
S
R
-----
R
--
G
VS
R
E
D
I
E
R
-------
E
V
S
I
L
K
E
I
-
Q
-
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
E
S
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
R
I
K
I
I
D
F
G
L
A
-
H
K
-----
I
---
D
FG
N
---
E
F
K
-
N
I
F
G
T
P
E
F
V
A
P
E
I
V
------
N
Y
E
P
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
--
G
D
T
K
-
Q
E
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
-
I
----
K
P
K
D
T
Q
Q
A
L
S
R
K
A
C
A
V
N
M
E
K
F
K
K
F
A
A
R
---------------------------------------------------------------------
108
PsiBlast_CBE
71.77
38%
-112
- C1 -
2CKE
1
DAPK2_HUMAN
C:
[14-276]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
D
I
G
E
E
L
G
S
G
Q
F
A
I
V
K
K
C
R
E
K
S
T
G
L
E
Y
A
A
K
F
I
K
K
R
Q
S
R
A
S
R
RGVSR
E
--
E
-----
I
E
R
-------
E
V
S
I
L
R
Q
V
-
L
-
H
H
N
V
I
T
L
H
D
V
Y
E
N
R
T
D
V
V
L
I
L
E
L
V
S
G
G
E
L
F
D
F
L
A
Q
K
E
S
L
S
E
E
E
A
T
S
F
I
K
Q
I
L
D
G
V
N
Y
L
H
T
K
K
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
K
N
I
P
I
P
H
I
K
L
I
D
F
G
L
A
H
E
I
-----
E
---
D
--
G
---
V
E
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
------
N
Y
E
P
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
--
L
G
D
T
K
-
Q
E
T
L
A
N
I
T
S
V
S
Y
D
F
D
E
E
F
F
S
H
T
S
E
L
A
K
D
F
I
R
K
L
L
V
K
E
T
R
K
R
L
T
I
Q
E
A
L
R
H
P
W
-
I
----
T
P
V
D
N
Q
Q
A
M
V
R
R
E
S
V
V
N
L
E
N
F
R
K
Q
Y
V
----------------------------------------------------------------------
76
PsiBlast_CBE
71.28
38%
-113
- C1 -
2YAA
1
DAPK2_MOUSE
A:
[14-276]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
D
I
G
E
E
L
G
S
G
Q
F
A
I
V
K
K
C
R
E
K
S
T
G
L
E
Y
A
A
K
F
I
K
K
R
Q
S
R
A
S
R
RGVC
R
E
--
E
-----
I
E
R
-------
E
V
S
I
L
R
Q
V
-
L
-
H
P
N
I
I
T
L
H
D
V
Y
E
N
R
T
D
V
V
L
I
L
E
L
V
S
G
G
E
L
F
D
F
L
A
Q
K
E
S
L
S
E
E
E
A
T
S
F
I
K
Q
I
L
D
G
V
N
Y
L
H
T
K
K
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
K
N
I
P
I
P
H
I
K
L
I
D
F
G
L
A
H
E
I
-----
E
---
D
--
G
---
V
E
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
------
N
Y
E
P
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
--
L
G
D
T
K
-
Q
E
T
L
A
N
I
T
A
V
S
Y
D
F
D
E
E
F
F
S
Q
T
S
E
L
A
K
D
F
I
R
K
L
L
V
K
E
T
R
K
R
L
T
I
Q
E
A
L
R
H
P
W
-
I
----
T
P
V
D
T
Q
Q
A
M
V
R
R
E
S
V
V
N
L
E
N
F
K
K
Q
Y
V
----------------------------------------------------------------------
110
PsiBlast_CBE
71.12
38%
-114
- C1 -
2CKE
1
DAPK2_HUMAN
A:
[14-276]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
D
I
G
E
E
L
G
S
G
Q
F
A
I
V
K
K
C
R
E
K
S
T
G
L
E
Y
A
A
K
F
I
K
K
R
Q
S
R
A
S
R
R
G
V
S
R
E
--
E
-----
I
E
R
-------
E
V
S
I
L
R
Q
V
-
L
-
H
H
N
V
I
T
L
H
D
V
Y
E
N
R
T
D
V
V
L
I
L
E
L
V
S
G
G
E
L
F
D
F
L
A
Q
K
E
S
L
S
E
E
E
A
T
S
F
I
K
Q
I
L
D
G
V
N
Y
L
H
T
K
K
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
K
N
I
P
I
P
H
I
K
L
I
D
F
G
L
A
H
E
I
-----
E
---
D
--
G
---
V
E
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
------
N
Y
E
P
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
--
L
G
D
T
K
-
Q
E
T
L
A
N
I
T
S
V
S
Y
D
F
D
E
E
F
F
S
H
T
S
E
L
A
K
D
F
I
R
K
L
L
V
K
E
T
R
K
R
L
T
I
Q
E
A
L
R
H
P
W
-
I
----
T
P
V
D
N
Q
Q
A
M
V
R
R
E
S
V
V
N
L
E
N
F
R
K
Q
Y
V
----------------------------------------------------------------------
107
PsiBlast_CBE
70.78
38%
-112
* C1 *
2CKE
1
DAPK2_HUMAN
D:
[14-276]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
D
I
G
E
E
L
G
S
G
Q
F
A
I
V
K
K
C
R
E
K
S
T
G
L
E
Y
A
A
K
F
I
K
K
R
Q
S
R
A
S
R
RGVSR
E
--
E
-----
I
E
R
-------
E
V
S
I
L
R
Q
V
-
L
-
H
H
N
V
I
T
L
H
D
V
Y
E
N
R
T
D
V
V
L
I
L
E
L
V
S
G
G
E
L
F
D
F
L
A
Q
K
E
S
L
S
E
E
E
A
T
S
F
I
K
Q
I
L
D
G
V
N
Y
L
H
T
K
K
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
K
N
I
P
I
P
H
I
K
L
I
D
F
G
L
A
H
E
I
-----
E
---
D
--
G
---
V
E
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
------
N
Y
E
P
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
--
L
G
D
T
K
-
Q
E
T
L
A
N
I
T
S
V
S
Y
D
F
D
E
E
F
F
S
H
T
S
E
L
A
K
D
F
I
R
K
L
L
V
K
E
T
R
K
R
L
T
I
Q
E
A
L
R
H
P
W
-
I
----
T
P
V
D
N
Q
Q
A
M
V
R
R
E
S
V
V
N
L
E
N
F
R
K
Q
Y
V
----------------------------------------------------------------------
8
PsiBlast_PDB
70.35
41%
-93
- C1 -
2W4O
1
KCC4_HUMAN
A:
[50-346]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
---
L
S
D
F
F
E
V
E
S
E
L
G
R
G
A
T
S
I
V
Y
R
C
K
Q
K
G
T
Q
K
P
Y
A
L
K
V
L
K
K
--------------------------------
I
G
V
L
L
R
L
-
S
-
H
P
N
I
I
K
L
K
E
I
F
E
T
P
T
E
I
S
L
V
L
E
L
V
T
G
G
E
L
F
D
R
I
V
E
K
G
Y
Y
S
E
R
D
A
A
D
A
V
K
Q
I
L
E
A
V
A
Y
L
H
E
N
G
I
V
H
R
D
L
K
P
E
N
L
L
-
Y
A
T
P
A
P
D
A
P
L
K
I
A
D
F
-----------------------------
G
T
P
G
Y
C
A
P
E
I
L
------
R
G
C
A
Y
-
G
P
E
V
D
M
W
S
V
G
I
I
T
Y
I
L
L
C
G
F
E
P
F
Y
D
E
R
G
D
Q
--
F
M
F
R
R
I
L
N
C
E
Y
Y
F
I
S
P
W
W
D
E
V
S
L
N
A
K
D
L
V
R
K
L
I
V
L
D
P
K
K
R
L
T
T
F
Q
A
L
Q
H
P
W
-
V
----
T
--
G
K
A
A
N
F
V
H
M
D
T
A
Q
K
K
L
Q
E
F
N
A
R
R
K
L
K
--
A
A
V
K
A
V
V
A
S
S
-------------------------------------------------------
106
PsiBlast_CBE
70.30
38%
-111
- C1 -
4CZU
3
CIPKN_ARATH
A:
[12-267]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
Y
E
L
G
R
T
L
G
E
G
T
F
A
K
V
K
F
A
R
N
V
E
N
G
D
N
V
A
I
K
V
I
D
K
E
K
V
L
K
N
K
-----
M
--
I
A
Q
---
I
K
R
-------
E
I
S
T
M
K
L
I
-
K
-
H
P
N
V
I
R
M
F
E
V
M
A
S
K
T
K
I
Y
F
V
L
E
F
V
T
G
G
E
L
F
D
K
I
S
S
N
G
R
L
K
E
D
E
A
R
K
Y
F
Q
Q
L
I
N
A
V
D
Y
C
H
S
R
G
V
Y
H
R
D
L
K
P
E
N
L
L
L
----
D
A
N
G
A
L
K
V
S
D
F
G
L
S
-
A
L
PQQVR
E
---
D
--
G
---
L
L
H
-
D
T
C
G
T
P
N
Y
V
A
P
E
V
I
------
N
N
K
G
Y
D
G
A
K
A
D
L
W
S
C
G
V
I
L
F
V
L
M
A
G
Y
L
P
F
E
D
S
--
N
L
-
T
S
L
Y
K
K
I
F
--
K
A
E
F
T
C
P
P
W
--
F
S
A
S
A
K
K
L
I
K
R
I
L
D
P
N
P
A
T
R
I
T
F
A
E
V
I
E
N
E
W
-
F
----
K
K
G
Y
K
A
P
K
F
E
N
D
D
V
D
A
I
F
D
D
S
G
E
S
K
N
L
V
V
-------------------------------------------------------------------
31
PsiBlast_CBE
70.23
39%
-96
- C1 -
4D9T
1
A:
[20-291]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
T
D
G
Y
E
V
K
E
D
I
G
V
G
S
Y
S
V
C
K
R
C
I
H
K
A
T
N
M
E
F
A
V
K
I
I
D
K
S
K
R
D
P
T
E
------------------------
E
I
E
I
L
L
R
Y
G
Q
-
H
P
N
I
I
T
L
K
D
V
Y
D
D
G
K
Y
V
Y
V
V
T
E
L
M
K
G
G
E
L
L
D
K
I
L
R
Q
K
F
F
S
E
R
E
A
S
A
V
L
F
T
I
T
K
T
V
E
Y
L
H
A
Q
G
V
V
H
R
D
L
K
P
S
N
I
L
Y
V
D
E
S
G
N
P
E
S
I
R
I
C
D
F
G
F
A
-
K
Q
-----
L
RAE
N
--
G
---
L
L
M
-
T
P
C
Y
T
A
N
F
V
A
P
E
V
L
------
E
R
Q
G
Y
-
D
A
A
C
D
I
W
S
L
G
V
L
L
Y
T
M
L
T
G
Y
T
P
F
A
N
G
P
D
D
T
P
E
E
I
L
A
R
I
G
S
G
K
F
S
L
S
G
G
Y
W
N
S
V
S
D
T
A
K
D
L
V
S
K
M
L
H
V
D
P
H
Q
R
L
T
A
A
L
V
L
R
H
P
W
I
V
----
H
W
D
Q
L
P
Q
Y
Q
L
N
R
Q
D
A
P
H
L
V
K
G
A
M
A
A
T
Y
S
A
L
N
R
N
---------------------------------------------------------------
89
PsiBlast_CBE
70.12
38%
-108
- C1 -
4CZT
3
CIPKN_ARATH
C:
[12-267]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
Y
E
L
G
R
T
L
G
E
G
T
F
A
K
V
K
F
A
R
N
V
E
N
G
D
N
V
A
I
K
V
I
D
K
E
K
V
L
K
N
K
-----
M
--
I
A
Q
---
I
K
R
-------
E
I
S
T
M
K
L
I
-
K
-
H
P
N
V
I
R
M
F
E
V
M
A
S
K
T
K
I
Y
F
V
L
E
F
V
T
G
G
E
L
F
D
K
I
S
S
N
G
R
L
K
E
D
E
A
R
K
Y
F
Q
Q
L
I
N
A
V
D
Y
C
H
S
R
G
V
Y
H
R
D
L
K
P
E
N
L
L
L
----
D
A
N
G
A
L
K
V
S
D
F
G
L
S
-
A
L
PQQVR
E
---
D
--
G
---
L
L
H
-
T
T
C
G
T
P
N
Y
V
A
P
E
V
I
------
N
N
K
G
Y
D
G
A
K
A
D
L
W
S
C
G
V
I
L
F
V
L
M
A
G
Y
L
P
F
E
D
S
--
N
L
-
T
S
L
Y
K
K
I
F
--
K
A
E
F
T
C
P
P
W
--
F
S
A
S
A
K
K
L
I
K
R
I
L
D
P
N
P
A
T
R
I
T
F
A
E
V
I
E
N
E
W
-
F
----
K
K
G
Y
K
A
P
K
F
E
N
A
D
V
S
L
D
D
V
D
A
I
F
D
D
S
G
---------------------------------------------------------------------
104
PsiBlast_CBE
70.00
38%
-110
- C1 -
4CZU
3
CIPKN_ARATH
C:
[12-267]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
Y
E
L
G
R
T
L
G
E
G
T
F
A
K
V
K
F
A
R
N
V
E
N
G
D
N
V
A
I
K
V
I
D
K
E
K
V
L
K
N
K
-----
M
--
I
A
Q
---
I
K
R
-------
E
I
S
T
M
K
L
I
-
K
-
H
P
N
V
I
R
M
F
E
V
M
A
S
K
T
K
I
Y
F
V
L
E
F
V
T
G
G
E
L
F
D
K
I
S
S
N
G
R
L
K
E
D
E
A
R
K
Y
F
Q
Q
L
I
N
A
V
D
Y
C
H
S
R
G
V
Y
H
R
D
L
K
P
E
N
L
L
L
----
D
A
N
G
A
L
K
V
S
D
F
G
L
S
-
A
L
PQQVR
E
---
D
--
G
---
L
L
H
-
D
T
C
G
T
P
N
Y
V
A
P
E
V
I
------
N
N
K
G
Y
D
G
A
K
A
D
L
W
S
C
G
V
I
L
F
V
L
M
A
G
Y
L
P
F
E
D
S
--
N
L
-
T
S
L
Y
K
K
I
F
--
K
A
E
F
T
C
P
P
W
--
F
S
A
S
A
K
K
L
I
K
R
I
L
D
P
N
P
A
T
R
I
T
F
A
E
V
I
E
N
E
W
-
F
----
K
K
G
Y
K
A
P
K
F
E
N
A
D
V
D
A
I
F
D
D
S
---------------------------------------------------------------------------
71
PsiBlast_CBE
69.97
37%
-111
- C1 -
3ZXT
1
DAPK1_HUMAN
A:
[9-275]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
D
D
Y
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
R
T
-------------R
E
D
--
I
E
R
-------
E
V
S
I
L
K
E
I
-
Q
-
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
E
S
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
-
V
P
K
P
R
I
K
I
I
D
F
G
L
A
-
H
K
-----
I
---
D
----------------
E
F
V
A
P
E
I
V
------
N
Y
E
P
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
--
G
D
T
K
-
Q
E
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
-
I
----
K
-----------------------------------------------------------------------------------------------
30
PsiBlast_CBE
69.95
39%
-98
- C1 -
4D9U
1
A:
[20-291]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
T
D
G
Y
E
V
K
E
D
I
G
V
G
S
Y
S
V
C
K
R
C
I
H
K
A
T
N
M
E
F
A
V
K
I
I
D
K
S
K
R
D
P
T
E
------------------------
E
I
E
I
L
L
R
Y
G
Q
-
H
P
N
I
I
T
L
K
D
V
Y
D
D
G
K
Y
V
Y
V
V
T
E
L
M
K
G
G
E
L
L
D
K
I
L
R
Q
K
F
F
S
E
R
E
A
S
A
V
L
F
T
I
T
K
T
V
E
Y
L
H
A
Q
G
V
V
H
R
D
L
K
P
S
N
I
L
Y
V
D
E
S
G
N
P
E
S
I
R
I
C
D
F
G
F
A
-
K
Q
-----
L
RAE
N
--
G
---
L
L
M
-
T
P
C
Y
T
A
N
F
V
A
P
E
V
L
------
E
R
Q
G
Y
-
D
A
A
C
D
I
W
S
L
G
V
L
L
Y
T
M
L
T
G
Y
T
P
F
A
N
G
P
D
D
T
P
E
E
I
L
A
R
I
G
S
G
K
F
S
L
S
G
G
Y
W
N
S
V
S
D
T
A
K
D
L
V
S
K
M
L
H
V
D
P
H
Q
R
L
T
A
A
L
V
L
R
H
P
W
I
V
----
H
W
D
Q
L
P
Q
Y
Q
L
N
R
Q
D
A
P
H
L
V
K
G
A
M
A
A
T
Y
S
A
L
N
R
N
Q
--------------------------------------------------------------
68
PsiBlast_CBE
69.60
37%
-116
- C1 -
3ZXT
1
DAPK1_HUMAN
D:
[9-275]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
D
D
Y
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
------------------VS
R
E
D
I
E
R
-------
E
V
S
I
L
K
E
I
-
Q
-
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
----
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
R
I
K
I
I
D
F
G
L
A
-
H
K
-----
I
---
D
--------------
T
P
E
F
V
A
P
E
I
V
------
N
Y
E
P
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
--
G
D
T
K
-
Q
E
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
-
I
----
K
-----------------------------------------------------------------------------------------------
91
PsiBlast_CBE
69.12
38%
-106
- C1 -
4CZT
3
CIPKN_ARATH
A:
[12-267]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
Y
E
L
G
R
T
L
G
E
G
T
F
A
K
V
K
F
A
R
N
V
E
N
G
D
N
V
A
I
K
V
I
D
K
E
K
V
L
K
N
K
-----
M
--
I
A
Q
---
I
K
R
-------
E
I
S
T
M
K
L
I
-
K
-
H
P
N
V
I
R
M
F
E
V
M
A
S
K
T
K
I
Y
F
V
L
E
F
V
T
G
G
E
L
F
D
K
I
S
S
N
G
R
L
K
E
D
E
A
R
K
Y
F
Q
Q
L
I
N
A
V
D
Y
C
H
S
R
G
V
Y
H
R
D
L
K
P
E
N
L
L
L
----
D
A
N
G
A
L
K
V
S
D
F
G
L
S
-
A
L
PQQVR
E
---
D
--
G
---
L
L
H
-
T
T
C
G
T
P
N
Y
V
A
P
E
V
I
------
N
N
K
G
Y
D
G
A
K
A
D
L
W
S
C
G
V
I
L
F
V
L
M
A
G
Y
L
P
F
E
D
S
--
N
L
-
T
S
L
Y
K
K
I
F
--
K
A
E
F
T
C
P
P
W
--
F
S
A
S
A
K
K
L
I
K
R
I
L
D
P
N
P
A
T
R
I
T
F
A
E
V
I
E
N
E
W
-
F
----
K
K
G
Y
K
A
P
K
F
E
N
V
S
L
D
D
V
D
A
I
F
D
D
S
G
E
S
---------------------------------------------------------------------
70
PsiBlast_CBE
69.10
37%
-107
- C1 -
3ZXT
1
DAPK1_HUMAN
B:
[9-275]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
D
D
Y
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
R
T
K
S
-
R
-----
R
--
G
VS
R
E
D
I
E
R
-------
E
V
S
I
L
K
E
I
-
Q
-
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
--
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
R
I
K
I
I
D
F
G
L
A
-
H
K
-----
I
---
D
--------------
T
P
E
F
V
A
P
E
I
V
------
N
Y
E
P
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
-
S
G
A
S
P
F
L
--
G
D
T
K
-
Q
E
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
---
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
-
I
----
K
-----------------------------------------------------------------------------------------------
90
PsiBlast_CBE
69.02
38%
-104
- C1 -
4CZT
2
CIPKN_ARATH
B:
[12-267]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
Y
E
L
G
R
T
L
G
E
G
T
F
A
K
V
K
F
A
R
N
V
E
N
G
D
N
V
A
I
K
V
I
D
K
E
K
V
L
K
N
K
-----
M
--
I
A
Q
---
I
K
R
-------
E
I
S
T
M
K
L
I
-
K
-
H
P
N
V
I
R
M
F
E
V
M
A
S
K
T
K
I
Y
F
V
L
E
F
V
T
G
G
E
L
F
D
K
I
S
S
N
G
R
L
K
E
D
E
A
R
K
Y
F
Q
Q
L
I
N
A
V
D
Y
C
H
S
R
G
V
Y
H
R
D
L
K
P
E
N
L
L
L
----
D
A
N
G
A
L
K
V
S
D
F
G
L
S
-
A
L
PQQVR
E
---
D
--
G
---
L
L
H
-
T
T
C
G
T
P
N
Y
V
A
P
E
V
I
------
N
N
K
G
Y
D
G
A
K
A
D
L
W
S
C
G
V
I
L
F
V
L
M
A
G
Y
L
P
F
E
D
S
--
N
L
-
T
S
L
Y
K
K
I
F
--
K
A
E
F
T
C
P
P
W
--
F
S
A
S
A
K
K
L
I
K
R
I
L
D
P
N
P
A
T
R
I
T
F
A
E
V
I
E
N
E
W
-
F
----
K
K
G
Y
K
A
P
K
F
E
D
D
V
D
A
I
F
D
D
S
G
---------------------------------------------------------------------------
69
PsiBlast_CBE
68.84
37%
-110
- C1 -
3ZXT
1
DAPK1_HUMAN
C:
[9-275]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
D
D
Y
Y
D
T
G
E
E
L
G
--
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
R
T
K
S
S
R
-----
R
--
G
VS
R
E
D
I
E
R
-------
E
V
S
I
L
K
E
I
-
Q
-
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
E
S
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
R
I
K
I
I
D
F
G
L
A
-
H
K
-----
I
---
D
---------------
P
E
F
V
A
P
E
I
V
------
N
Y
E
P
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
--
G
D
T
K
-
Q
E
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
-
I
----
K
-----------------------------------------------------------------------------------------------
105
PsiBlast_CBE
68.58
38%
-102
- C1 -
4CZU
3
CIPKN_ARATH
B:
[12-267]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
Y
E
L
G
R
T
L
G
E
G
T
F
A
K
V
K
F
A
R
N
V
E
N
G
D
N
V
A
I
K
V
I
D
K
E
K
V
L
K
N
K
-----
M
--
I
A
Q
---
I
K
R
-------
E
I
S
T
M
K
L
I
-
K
-
H
P
N
V
I
R
M
F
E
V
M
A
S
K
T
K
I
Y
F
V
L
E
F
V
T
G
G
E
L
F
D
K
I
S
S
N
G
R
L
K
E
D
E
A
R
K
Y
F
Q
Q
L
I
N
A
V
D
Y
C
H
S
R
G
V
Y
H
R
D
L
K
P
E
N
L
L
L
----
D
A
N
G
A
L
K
V
S
D
F
G
L
S
-
A
L
PQQVR
E
---
D
--
G
---
L
L
H
-
D
T
C
G
T
P
N
Y
V
A
P
E
V
I
------
N
N
K
G
Y
D
G
A
K
A
D
L
W
S
C
G
V
I
L
F
V
L
M
A
G
Y
L
P
F
E
D
S
--
N
L
-
T
S
L
Y
K
K
I
F
--
K
A
E
F
T
C
P
P
W
--
F
S
A
S
A
K
K
L
I
K
R
I
L
D
P
N
P
A
T
R
I
T
F
A
E
V
I
E
N
E
W
-
F
----
K
K
G
Y
K
A
P
K
F
E
D
D
V
D
A
I
F
D
D
S
G
---------------------------------------------------------------------------
88
PsiBlast_CBE
68.45
38%
-106
- C1 -
4CZT
4
CIPKN_ARATH
D:
[12-267]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
Y
E
L
G
R
T
L
G
E
G
T
F
A
K
V
K
F
A
R
N
V
E
N
G
D
N
V
A
I
K
V
I
D
K
E
K
V
L
K
N
K
-----
M
--
I
A
Q
---
I
K
R
-------
E
I
S
T
M
K
L
I
-
K
-
H
P
N
V
I
R
M
F
E
V
M
A
S
K
T
K
I
Y
F
V
L
E
F
V
T
G
G
E
L
F
D
K
I
S
S
N
G
R
L
K
E
D
E
A
R
K
Y
F
Q
Q
L
I
N
A
V
D
Y
C
H
S
R
G
V
Y
H
R
D
L
K
P
E
N
L
L
L
----
D
A
N
G
A
L
K
V
S
D
F
G
L
S
-
A
L
PQQVR
E
---
D
--
G
---
L
L
H
-
T
T
C
G
T
P
N
Y
V
A
P
E
V
I
------
N
N
K
G
Y
D
G
A
K
A
D
L
W
S
C
G
V
I
L
F
V
L
M
A
G
Y
L
P
F
E
D
S
--
N
L
-
T
S
L
Y
K
K
I
F
--
K
A
E
F
T
C
P
P
W
--
F
S
A
S
A
K
K
L
I
K
R
I
L
D
P
N
P
A
T
R
I
T
F
A
E
V
I
E
N
E
W
-
F
----
K
K
G
Y
K
A
P
K
F
E
N
A
D
V
S
L
D
D
V
D
A
I
F
D
D
S
N
L
V
V
E
R
R
E
--------------------------------------------------------------
41
PsiBlast_CBE
66.13
39%
-100
- C1 -
2WEI
1
?
A:
[12-281]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
N
L
Y
F
Q
G
T
---
F
A
E
R
Y
N
I
V
C
M
L
G
K
G
S
F
G
E
V
L
K
C
K
D
R
I
T
Q
Q
E
Y
A
V
K
V
I
N
K
A
S
A
K
N
K
D
T
----
S
--
T
-----
I
L
R
-------
E
V
E
L
L
K
K
L
-
D
-
H
P
N
I
M
K
L
F
E
I
L
E
D
S
S
S
F
Y
I
V
G
E
L
Y
T
G
G
E
L
F
D
E
I
I
K
R
K
R
F
S
E
H
D
A
A
R
I
I
K
Q
V
F
S
G
I
T
Y
M
H
K
H
N
I
V
H
R
D
L
K
P
E
N
I
L
L
-
E
S
K
E
K
D
C
D
I
K
I
I
D
F
G
L
S
-
T
C
-----
F
QQ-
N
--
T
---
K
M
K
-
D
R
I
G
T
A
Y
Y
I
A
P
E
V
L
------
R
G
T
-
Y
-
D
E
K
C
D
V
W
S
A
G
V
I
L
Y
I
L
L
S
G
T
P
P
F
Y
G
K
N
E
Y
D
---
I
L
K
R
V
E
T
G
K
Y
A
F
D
L
P
Q
W
R
T
I
S
D
D
A
K
D
L
I
R
K
M
L
T
F
H
P
S
L
R
I
T
A
T
Q
C
L
E
H
P
W
-
I
----
Q
K
Y
S
S
E
------------------------------------------------------------------------------------------