@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : DCLK3_HUMAN: (2015-10-06 )
MGKEPLTLKSIQVAVEELYPNKARALTLAQHSRAPSPRLRSRLFSKALKGDHRCGETETPKSCSEVAGCKAAMRHQGKIPEELSLDDRARTQKKWGRGKWEPEPSSKPPREATLEERHARGEKHLGVEIEKTSGEIIRCEKCKRERELQQSLERERLSLGTSELDMGKGPMYDVEKLVRTRSCRRSPEANPASGEEGWKGDSHRSSPRNPTQELRRPSKSMDKKEDRGPEDQESHAQGAAKAKKDLVEVLPVTEEGLREVKKDTRPMSRSKHGGWLLREHQAGFEKLRRTRGEEKEAEKEKKPCMSGGRRMTLRDDQPAKLEKEPKTRPEENKPERPSGRKPRPMGIIAANVEKHYETGRVIGDGNFAVVKECRHRETRQAYAMKIIDKSRLKGKEDMVDSEILIIQSLSHPNIVKLHEVYETDMEIYLILEYVQGGDLFDAIIESVKFPEPDAALMIMDLCKALVHMHDKSIVHRDLKPENLLVQRNEDKSTTLKLADFGLAKHVVRPIFTVCGTPTYVAPEILSEKGYGLEVDMWAAGVILYILLCGFPPFRSPERDQDELFNIIQLGHFEFLPPYWDNISDAAKDLVSRLLVVDPKKRYTAHQVLQHPWIETAGKTNTVKRQKQVSPSSEGHFRSQHKRVVEQVS
Atome Classification :
(85 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340....-----..-.350.......360.......370.......380.......-----390------....------.--.-.----.-.400.......410........420.......430.......440.....-------------------------------..--------450.......460.......470.......480-.......490.......500...--.-----.-----.----.---510-.-........520...------...--.530........540.......550.......560.......570.......580.......590.......600.......610.-......620.......630.......640......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MGKEPL
T
L
K
S
I
Q
V
A
V
E
E
LYPNKA
R
A
L
T
L
A
Q
HSRAP
S
P
R
L
R
S
R
L
F
S
K
A
LKGDHRCGETETP
K
S
C
S
E
V
A
G
C
K
A
A
M
R
HQGKIPEELSL
D
D
R
A
R
T
Q
K
KWGRGKWEPEPSSKPP
R
E
A
T
L
E
E
R
HARGEKHL
G
V
E
I
EKTSG
E
I
I
R
C
E
K
C
K
R
E
R
E
L
Q
Q
S
L
E
R
E
R
L
SLGTSELDMGKG
P
M
Y
D
V
E
K
L
V
R
T
R
S
CRRSPEANPASGEEGWKGDSHRSSPRN
P
T
Q
E
L
RRPSKSMDKKEDRGPE
D
Q
E
S
H
A
Q
G
A
A
K
A
K
K
D
L
V
E
VLPV
T
E
E
G
L
R
E
V
K
K
DTRPMSRSKHG
G
W
L
L
R
E
H
Q
A
G
F
E
K
L
R
R
TRGE
E
K
E
A
E
K
EKKPCMSGG
R
R
M
TLRDDQPAKLEKEPKTRPEENKPERPSGRKPR
P
M
G
-----
I
I
-
A
A
N
V
E
K
H
YETG
R
V
IGDG
N
F
A
V
V
K
E
C
R
H
R
E
T
R
Q
A
Y
A
M
K
I
I
D
K
-----S--------RLKG------K--E-D----M-VDS
E
I
L
I
I
QSLS-HP
N
I
V
K
L
H
E
V
Y
ETD
M
E
I
Y
L
I
L
E
YVQGG
D
L
F
D
A
I
I
E
SV-------------------------------KF--------PEP
D
A
A
L
M
I
M
D
L
C
K
A
L
V
H
MH
D
K
S
I
V
HRDLKPE
N
-
L
L
V
QRNEDKS
T
T
L
K
L
A
D
F
G
L
A
K
H
--
V
-----
V
-----
R
----
P
---
I
---
F
-
T
VCGTP
T
Y
V
A
P
E
I
L
------SEK--GY-
G
L
E
V
D
M
W
A
A
G
V
I
L
Y
I
L
L
CGFPPFRSPER
D
Q
D
E
L
F
N
I
I
Q
LGHFEFLP
P
Y
WD
N
I
S
D
A
A
K
D
L
V
S
R
L
LVVDPKKR
Y
T
A
H
Q
V
L
QHPWI-ETAGKTN
T
V
K
R
Q
KQVSPSSEG
H
F
R
S
Q
H
K
R
V
V
E
QVS
9
PsiBlast_PDB
84.27
41%
-121
- C1 -
2WEL
7
KCC2D_HUMAN
A:
[6-280]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
Q
L
F
E
E
L
G
K
G
A
F
S
V
V
R
R
C
M
K
I
P
T
G
Q
E
Y
A
A
K
I
I
N
T
-----
K
--------
K
L
S
A
------
R
--
D
-
H
----
Q
K
L
E
R
E
A
R
I
C
R
L
L
K
-
H
P
N
I
V
R
L
H
D
S
I
S
E
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
E
-------------------------------
Y
Y
--------
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
L
N
G
I
V
H
R
D
L
K
P
E
N
-
L
L
L
A
-
S
K
S
K
G
A
A
V
K
L
A
D
F
G
L
A
I
E
--
V
Q
GD--
Q
-----
Q
----
A
---
W
---
F
-
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
------
R
K
D
--
P
Y
-
G
K
P
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
--
D
E
D
Q
H
R
L
Y
Q
Q
I
K
A
G
A
Y
D
F
P
S
P
E
W
D
T
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
A
K
R
I
T
A
S
E
A
L
K
H
P
W
I
C
Q
R
----
S
M
M
H
R
Q
E
T
V
D
C
L
K
K
F
N
A
R
R
K
L
K
G
A
I
L
T
T
M
17
PsiBlast_PDB
80.47
43%
-119
- C1 -
4UV0
1
?
A:
[5-277]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
F
R
Q
E
N
V
D
D
Y
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
-----
R
--------
R
T
K
S
SRRGVS
R
--
E
-
D
------
I
E
R
E
V
S
I
L
K
E
I
Q
-
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
E
-------------------------------
S
L
--------
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
-
R
I
K
I
I
D
F
G
L
A
H
K
--
I
DFG
N
E
F
-----
K
----
N
---
I
---
F
----
G
T
P
E
F
V
A
P
E
I
V
------
N
Y
E
--
P
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
K
-
Q
E
T
L
A
N
V
S
A
V
-
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
-
K
P
K
D
T
Q
Q
A
L
S
R
K
A
C
A
V
N
M
E
K
F
K
K
F
A
A
R
--------
130
HHSearch
80.22
41%
-123
- C1 -
2Y0A
1
DAPK1_HUMAN
A:
[6-278]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
E
N
V
D
D
Y
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
-----
R
--------
R
T
K
S
SRRGV-
S
--
R
-
E
----
D
-
I
E
R
E
V
S
I
L
K
E
I
Q
-
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
E
-------------------------------
S
L
--------
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
-
I
M
L
L
D
R
N
V
P
K
P
R
I
K
I
I
D
F
G
L
A
H
K
--
I
-----
D
FG---
N
----
E
---
F
---
K
-
N
I
F
G
T
P
E
F
V
A
P
E
I
V
------
N
Y
E
--
P
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
--
T
K
Q
E
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
-
K
P
K
D
T
Q
Q
A
L
S
R
K
A
S
A
V
N
M
E
K
F
K
K
F
A
A
R
--------
43
PsiBlast_CBE
80.04
43%
-112
- C1 -
1JKK
1
DAPK1_HUMAN
A:
[7-274]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
V
D
D
Y
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
-----
R
--------
R
T
K
S
SRRGVS
R
--
E
-
D
------
I
E
R
E
V
S
I
L
K
E
I
Q
-
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
E
-------------------------------
S
L
--------
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
-
R
I
K
I
I
D
F
G
L
A
H
K
--
I
DFGNE
F
-----
K
----
N
---
I
---
F
----
G
T
P
E
F
V
A
P
E
I
V
------
N
Y
E
--
P
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
K
-
Q
E
T
L
A
N
V
S
A
V
-
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
-
K
P
F
--------------------------------
35
PsiBlast_CBE
79.92
43%
-117
- C1 -
3DFC
1
DAPK1_HUMAN
B:
[8-275]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
V
D
D
Y
Y
D
T
G
E
E
L
G
S
G
K
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
-----
R
--------
R
T
K
S
SRRGVS
R
--
E
-
D
------
I
E
R
E
V
S
I
L
K
E
I
Q
-
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
E
-------------------------------
S
L
--------
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
-
R
I
K
I
I
D
F
G
L
A
H
K
--
I
DFGNE
F
-----
K
----
N
---
I
---
F
----
G
T
P
E
F
V
A
P
E
I
V
------
N
Y
E
--
P
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
K
-
Q
E
T
L
A
N
V
S
A
V
-
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
-
K
P
P
Q
F
E
-----------------------------
48
PsiBlast_CBE
79.88
43%
-115
- C1 -
2W4J
1
DAPK1_HUMAN
A:
[8-275]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
V
D
D
Y
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
-----
R
--------
R
T
K
S
SRRGVS
R
--
E
-
D
------
I
E
R
E
V
S
I
L
K
E
I
Q
-
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
E
-------------------------------
S
L
--------
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
-
R
I
K
I
I
D
F
G
L
A
H
K
--
I
DFG
N
E
F
-----
K
----
N
---
I
---
F
----
G
T
P
E
F
V
A
P
E
I
V
------
N
Y
E
--
P
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
K
-
Q
E
T
L
A
N
V
S
A
V
-
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
-
K
P
---------------------------------
15
PsiBlast_PDB
79.73
41%
-110
- C1 -
2VN9
2
KCC2D_HUMAN
A:
[6-280]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
Q
L
F
E
E
L
G
K
G
A
F
S
V
V
R
R
C
M
K
I
P
T
G
Q
E
Y
A
A
K
I
I
N
T
-----
K
--------
K
L
S
A
------
R
--
D
-
H
----
Q
K
L
E
R
E
A
R
I
C
R
L
L
K
-
H
P
N
I
V
R
L
H
D
S
I
S
E
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
E
-------------------------------
Y
Y
--------
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
L
N
G
I
V
H
R
D
L
K
P
E
N
-
L
L
L
A
-
S
K
S
K
G
A
A
V
K
L
A
D
F
G
L
A
I
E
--
V
Q
GD--
Q
-----
Q
----
A
---
W
---
F
-
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
------
R
K
D
--
P
Y
-
G
K
P
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
--
D
E
D
Q
H
R
L
Y
Q
Q
I
K
A
G
A
Y
D
F
P
S
P
E
W
D
T
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
A
K
R
I
T
A
S
E
A
L
K
H
P
W
I
C
Q
R
S
T
V
A
S
M
M
H
R
Q
E
T
V
D
C
L
K
K
F
N
A
R
R
K
L
K
G
A
I
L
T
T
M
37
PsiBlast_CBE
79.69
43%
-116
- C1 -
4YPD
1
DAPK1_HUMAN
A:
[7-274]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
V
D
D
Y
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
-----
R
--------
R
T
K
S
SRRGVS
R
--
E
-
D
------
I
E
R
E
V
S
I
L
K
E
I
Q
-
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
E
-------------------------------
S
L
--------
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
-
R
I
K
I
I
D
F
G
L
A
H
K
--
I
DFG
N
E
F
-----
K
----
N
---
I
---
F
----
G
T
P
E
F
V
A
P
E
I
V
------
N
Y
E
--
P
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
K
-
Q
E
T
L
A
N
V
S
A
V
-
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
-
K
P
P
Q
F
E
K
----------------------------
44
PsiBlast_CBE
79.62
43%
-115
- C1 -
1IG1
1
DAPK1_HUMAN
A:
[7-274]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
V
D
D
Y
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
-----
R
--------
R
T
K
S
SRRGVS
R
--
E
-
D
------
I
E
R
E
V
S
I
L
K
E
I
Q
-
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
E
-------------------------------
S
L
--------
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
-
R
I
K
I
I
D
F
G
L
A
H
K
--
I
DFGNE
F
-----
K
----
N
---
I
---
F
----
G
T
P
E
F
V
A
P
E
I
V
------
N
Y
E
--
P
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
K
-
Q
E
T
L
A
N
V
S
A
V
-
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
-
K
P
P
Q
F
E
-----------------------------
50
PsiBlast_CBE
79.57
43%
-117
- C1 -
3GU6
1
DAPK1_HUMAN
A:
[8-275]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
V
D
D
Y
Y
D
T
G
E
E
L
G
S
G
V
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
-----
R
--------
R
T
K
S
SRRGVS
R
--
E
-
D
------
I
E
R
E
V
S
I
L
K
E
I
Q
-
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
E
-------------------------------
S
L
--------
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
-
R
I
K
I
I
D
F
G
L
A
H
K
--
I
DFG
N
E
F
-----
K
----
N
---
I
---
F
----
G
T
P
E
F
V
A
P
E
I
V
------
N
Y
E
--
P
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
K
-
Q
E
T
L
A
N
V
S
A
V
-
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
-
K
P
P
Q
F
E
-----------------------------
25
PsiBlast_CBE
79.40
41%
-108
- C1 -
2VN9
1
KCC2D_HUMAN
B:
[6-280]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
Q
L
F
E
E
L
G
K
G
A
F
S
V
V
R
R
C
M
K
I
P
T
G
Q
E
Y
A
A
K
I
I
N
T
-----
K
--------
K
L
S
A
------
R
--
D
-
H
----
Q
K
L
E
R
E
A
R
I
C
R
L
L
K
-
H
P
N
I
V
R
L
H
D
S
I
S
E
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
E
-------------------------------
Y
Y
--------
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
L
N
G
I
V
H
R
D
L
K
P
E
N
-
L
L
L
A
-
S
K
S
K
G
A
A
V
K
L
A
D
F
G
L
A
I
E
--
V
QGD--
Q
-----
Q
----
A
---
W
---
F
-
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
------
R
K
D
--
P
Y
-
G
K
P
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
--
D
E
D
Q
H
R
L
Y
Q
Q
I
K
A
G
A
Y
D
F
P
S
P
E
W
D
T
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
A
K
R
I
T
A
S
E
A
L
K
H
P
W
I
C
Q
R
S
T
V
A
S
M
M
H
R
Q
E
T
V
D
C
L
K
K
F
N
A
R
R
K
L
K
G
A
I
L
T
T
M
56
PsiBlast_CBE
79.33
43%
-118
- C1 -
3GUB
1
DAPK1_HUMAN
A:
[8-275]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
V
D
D
Y
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
-----
R
--------
R
T
K
S
SRRGVS
R
--
E
-
D
------
I
E
R
E
V
S
I
L
K
E
I
Q
-
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
G
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
E
-------------------------------
S
L
--------
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
-
R
I
K
I
I
D
F
G
L
A
H
K
--
I
DFGNE
F
-----
K
----
N
---
I
---
F
----
G
T
P
E
F
V
A
P
E
I
V
------
N
Y
E
--
P
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
K
-
Q
E
T
L
A
N
V
S
A
V
-
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
-
K
P
Q
F
-------------------------------
28
PsiBlast_CBE
79.24
40%
-114
- C1 -
3BHH
1
KCC2B_HUMAN
B:
[6-280]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
Q
L
Y
E
D
I
G
K
---
S
V
V
R
R
C
V
K
L
C
T
G
H
E
Y
A
A
K
I
I
N
T
-----
K
--------
K
L
S
A
------
R
--
D
-
H
----
Q
K
L
E
R
E
A
R
I
C
R
L
L
K
-
H
S
N
I
V
R
L
H
D
S
I
S
E
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
E
-------------------------------
Y
Y
--------
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
A
V
L
H
C
H
Q
M
G
V
V
H
R
D
L
K
P
E
N
-
L
L
L
A
-
S
K
C
K
G
A
A
V
K
L
A
D
F
G
L
A
I
E
--
V
QGD--
Q
-----
Q
----
A
---
W
---
F
-
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
------
R
K
E
--
A
Y
-
G
K
P
V
D
I
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
--
D
E
D
Q
H
K
L
Y
Q
Q
I
K
A
G
A
Y
D
F
P
S
P
E
W
D
T
V
T
P
E
A
K
N
L
I
N
Q
M
L
T
I
N
P
A
K
R
I
T
A
H
E
A
L
K
H
P
W
V
C
Q
R
S
T
V
A
S
M
M
H
R
Q
E
T
V
E
C
L
K
K
F
N
A
R
R
K
L
K
-------
133
HHSearch
79.21
35%
-113
- C1 -
3HKO
2
?
A:
[20-337]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
-
L
L
E
L
Q
K
K
Y
H
L
K
G
A
I
G
Q
G
S
Y
G
V
V
R
V
A
I
E
N
Q
T
R
A
I
R
A
I
K
I
M
N
K
-----
N
--------
K
I
R
Q
K-----
D
--
V
-
E
----
R
-
I
K
T
E
V
R
L
M
K
K
L
H
-
H
P
N
I
A
R
L
Y
E
V
Y
E
D
E
Q
Y
I
C
L
V
M
E
L
C
H
G
G
H
L
L
D
K
L
N
V
F
I
DDSTG
K
C
A
M
D
V
V
KTQICPC
P
E
C
N
E
E
A
I
N
G
SI-
F
R
E
S
L
D
F
V
Q
R
E
K
L
I
S
N
I
M
R
Q
I
F
S
A
L
H
Y
L
H
N
Q
G
I
C
H
R
D
I
K
P
E
N
-
F
L
F
S
T
--
N
K
S
F
E
I
K
L
V
D
F
G
L
S
K
E
--
F
-----
Y
-----
K
LNNG------------
A
G
T
P
Y
F
V
A
P
E
V
L
------
N
T
T
NE
S
Y
-
G
P
K
C
D
A
W
S
A
G
V
L
L
H
L
L
L
M
G
A
V
P
F
P
G
V
--
N
D
A
D
T
I
S
Q
V
L
N
K
K
L
C
F
E
N
P
N
Y
N
V
L
S
P
L
A
R
D
L
L
S
N
L
L
N
R
N
V
D
E
R
F
D
A
M
R
A
L
Q
H
P
W
I
-
S
Q
F
S
D
K
I
Y
K
M
S
------------------------
92
PsiBlast_CBE
79.18
36%
-125
- C1 -
2Y7J
1
PHKG2_HUMAN
D:
[82-364]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ELPDW
A
A
-
A
K
E
F
Y
Q
K
Y
D
P
K
D
V
I
G
R
G
V
S
S
V
V
R
R
C
V
H
R
A
T
G
H
E
F
A
V
K
I
M
E
V
------RLSPE---
Q
L
E
E
------
V
--
R
-
E
----
A
-
T
R
R
E
T
H
I
L
R
Q
V
A
G
H
P
H
I
I
T
L
I
D
S
Y
E
S
S
S
F
M
F
L
V
F
D
L
M
R
K
G
E
L
F
D
Y
L
T
E
K
V
-------------------------------
A
L
--------
S
E
K
E
T
R
S
I
M
R
S
L
L
E
A
V
S
F
L
H
A
N
N
I
V
H
R
D
L
K
P
E
N
-
I
L
L
----
D
D
N
M
Q
I
R
L
S
D
F
G
F
S
C
H
--
L
-----
E
PG---
E
----
K
---
L
---
R
-
E
L
C
G
T
P
G
Y
L
A
P
E
I
L
KCSMDE
T
H
P
--
G
Y
-
G
K
E
V
D
L
W
A
C
G
V
I
L
F
T
L
L
A
G
S
P
P
F
W
--
H
R
R
Q
I
L
M
L
R
M
I
M
E
G
Q
Y
Q
F
S
S
P
E
W
D
D
R
S
S
T
V
K
D
L
I
S
R
L
L
Q
V
D
P
E
A
R
L
T
A
E
Q
A
L
Q
H
P
F
F
-
E
R
---------------------------------
144
HHSearch
79.17
44%
-126
* C1 *
4FG7
1
KCC1A_HUMAN
A:
[12-277]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
-
A
E
D
I
R
D
I
Y
D
F
R
D
V
L
G
T
G
A
F
S
E
V
I
L
A
E
D
K
R
T
Q
K
L
V
A
I
K
C
I
A
-----------------------------------
S
-
M
E
N
E
I
A
V
L
H
K
I
K
-
H
P
N
I
V
A
L
D
D
I
Y
E
S
G
G
H
L
Y
L
I
M
Q
L
V
S
G
G
E
L
F
D
R
I
V
E
K
G
-------------------------------
F
Y
--------
T
E
R
D
A
S
R
L
I
F
Q
V
L
D
A
V
K
Y
L
H
D
L
G
I
V
H
R
D
L
K
P
E
N
-
L
L
Y
Y
S
-
L
D
E
D
S
K
I
M
I
S
D
F
G
L
S
K
M
--
E
-----
D
-----
P
-----------------
G
T
P
G
Y
V
A
P
E
V
L
------
A
Q
K
-----
S
K
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
Y
D
E
--
N
D
A
K
L
F
E
Q
I
L
K
A
E
Y
E
F
D
S
P
Y
W
D
D
I
S
D
S
A
K
D
F
I
R
H
L
M
E
K
D
P
E
K
R
F
T
C
E
Q
A
L
Q
H
P
W
I
-
A
----------------------------------
20
PsiBlast_PDB
79.07
40%
-113
- C1 -
3BHH
1
KCC2B_HUMAN
A:
[6-280]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
Q
L
Y
E
D
I
G
----
S
V
V
R
R
C
V
K
L
C
T
G
H
E
Y
A
A
K
I
I
N
T
-----
K
--------
K
L
S
A
------
R
--
D
-
H
----
Q
K
L
E
R
E
A
R
I
C
R
L
L
K
-
H
S
N
I
V
R
L
H
D
S
I
S
E
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
E
-------------------------------
Y
Y
--------
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
A
V
L
H
C
H
Q
M
G
V
V
H
R
D
L
K
P
E
N
-
L
L
L
A
-
S
K
C
K
G
A
A
V
K
L
A
D
F
G
L
A
I
E
--
V
Q
GD--
Q
-----
Q
----
A
---
W
---
F
-
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
------
R
K
E
--
A
Y
-
G
K
P
V
D
I
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
--
D
E
D
Q
H
K
L
Y
Q
Q
I
K
A
G
A
Y
D
F
P
S
P
E
W
D
T
V
T
P
E
A
K
N
L
I
N
Q
M
L
T
I
N
P
A
K
R
I
T
A
H
E
A
L
K
H
P
W
V
C
Q
R
S
T
V
A
S
M
M
H
R
Q
E
T
V
E
C
L
K
K
F
N
A
R
R
K
L
K
-------
46
PsiBlast_CBE
79.04
43%
-117
- C1 -
1WVY
1
DAPK1_HUMAN
A:
[8-275]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
V
D
D
Y
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
-----
R
--------
R
T
K
S
SRRGVS
R
--
E
-
D
------
I
E
R
E
V
S
I
L
K
E
I
Q
-
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
E
-------------------------------
S
L
--------
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
-
R
I
K
I
I
D
F
G
L
A
H
K
--
I
DF
G
N
E
F
-----
K
----
N
---
I
---
F
----
G
T
P
E
F
V
A
P
E
I
V
------
N
Y
E
--
P
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
K
-
Q
E
T
L
A
N
V
S
A
V
-
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
-
K
----------------------------------
7
PsiBlast_PDB
78.95
43%
-127
- C1 -
4FG7
1
KCC1A_HUMAN
A:
[13-277]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
E
D
I
R
D
I
Y
D
F
R
D
V
L
G
T
G
A
F
S
E
V
I
L
A
E
D
K
R
T
Q
K
L
V
A
I
K
C
I
A
-----------------------------------
S
-
M
E
N
E
I
A
V
L
H
K
I
K
-
H
P
N
I
V
A
L
D
D
I
Y
E
S
G
G
H
L
Y
L
I
M
Q
L
V
S
G
G
E
L
F
D
R
I
V
E
K
G
-------------------------------
F
Y
--------
T
E
R
D
A
S
R
L
I
F
Q
V
L
D
A
V
K
Y
L
H
D
L
G
I
V
H
R
D
L
K
P
E
N
-
L
L
-
Y
Y
S
L
D
E
D
S
K
I
M
I
S
D
F
G
L
S
K
---
M
-----
E
-----
D
----
P
G------------
T
P
G
Y
V
A
P
E
V
L
------
A
Q
K
-----
S
K
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
Y
--
D
E
N
D
A
K
L
F
E
Q
I
L
K
A
E
Y
E
F
D
S
P
Y
W
D
D
I
S
D
S
A
K
D
F
I
R
H
L
M
E
K
D
P
E
K
R
F
T
C
E
Q
A
L
Q
H
P
W
I
---
A
--------------------------------
34
PsiBlast_CBE
78.94
43%
-117
- C1 -
2YAK
1
DAPK1_HUMAN
A:
[8-275]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
V
D
D
Y
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
-----
R
--------
R
T
K
S
SRRGVS
R
--
E
-
D
------
I
E
R
E
V
S
I
L
K
E
I
Q
-
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
E
-------------------------------
S
L
--------
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
-
R
I
K
I
I
D
F
G
L
A
H
K
--
I
DFG
N
E
F
-----
K
----
N
---
I
---
F
----
G
T
P
E
F
V
A
P
E
I
V
------
N
Y
E
--
P
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
K
-
Q
E
T
L
A
N
V
S
A
V
-
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
-
K
P
K
--------------------------------
36
PsiBlast_CBE
78.92
43%
-115
- C1 -
4TXC
7
DAPK1_HUMAN
A:
[27-294]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
V
D
D
Y
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
-----
R
--------
R
T
K
S
SRRGVS
R
--
E
-
D
------
I
E
R
E
V
S
I
L
K
E
I
Q
-
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
E
-------------------------------
S
L
--------
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
-
R
I
K
I
I
D
F
G
L
A
H
K
--
I
DFG
N
E
F
-----
K
----
N
---
I
---
F
----
G
T
P
E
F
V
A
P
E
I
V
------
N
Y
E
--
P
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
K
-
Q
E
T
L
A
N
V
S
A
V
-
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
-
K
P
---------------------------------
70
PsiBlast_CBE
78.88
39%
-123
- C1 -
2PHK
2
PHKG1_RABIT
A:
[4-275]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
N
Y
E
P
K
E
I
L
G
R
G
V
S
S
V
V
R
R
C
I
H
K
P
T
C
K
E
Y
A
V
K
I
I
D
V
-----
T
GGGSFS
A
E
E
V
Q
E
------
L
--
R
-
E
----
A
-
T
L
K
E
V
D
I
L
R
K
V
S
G
H
P
N
I
I
Q
L
K
D
T
Y
E
T
N
T
F
F
F
L
V
F
D
L
M
K
K
G
E
L
F
D
Y
L
T
E
K
V
-------------------------------
T
L
--------
S
E
K
E
T
R
K
I
M
R
A
L
L
E
V
I
C
A
L
H
K
L
N
I
V
H
R
D
L
K
P
E
N
-
I
L
L
----
D
D
D
M
N
I
K
L
T
D
F
G
F
S
C
Q
--
L
DP---
G
-----
E
----
K
---
L
---
R
-
E
V
C
G
T
P
S
Y
L
A
P
E
I
I
E
C
S
M
N
D
N
H
P
--
G
Y
-
G
K
E
V
D
M
W
S
T
G
V
I
M
Y
T
L
L
A
G
S
P
P
F
W
--
H
R
K
Q
M
L
M
L
R
M
I
M
S
G
N
Y
Q
F
G
S
P
E
W
D
D
Y
S
D
T
V
K
D
L
V
S
R
F
L
V
V
Q
P
Q
K
R
Y
T
A
E
E
A
L
A
H
P
F
F
-
Q
Q
Y
--------------------------------
38
PsiBlast_CBE
78.87
43%
-115
- C1 -
4YO4
1
DAPK1_HUMAN
A:
[7-274]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
V
D
D
Y
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
-----
R
--------
R
T
K
S
SRRGVS
R
--
E
-
D
------
I
E
R
E
V
S
I
L
K
E
I
Q
-
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
E
-------------------------------
S
L
--------
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
-
R
I
K
I
I
D
F
G
L
A
H
K
--
I
DFG
N
E
F
-----
K
----
N
---
I
---
F
----
G
T
P
E
F
V
A
P
E
I
V
------
N
Y
E
--
P
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
K
-
Q
E
T
L
A
N
V
S
A
V
-
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
-
K
P
Q
F
E
K
-----------------------------
40
PsiBlast_CBE
78.80
43%
-117
- C1 -
3EHA
1
DAPK1_HUMAN
A:
[7-274]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
V
D
D
Y
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
-----
R
--------
R
T
K
S
SRRGVS
R
--
E
-
D
------
I
E
R
E
V
S
I
L
K
E
I
Q
-
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
--------------------------------
S
L
--------
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
-
R
I
K
I
I
D
F
G
L
A
H
K
--
I
DFGNE
F
-----
K
----
N
---
I
---
F
----
G
T
P
E
F
V
A
P
E
I
V
------
N
Y
E
--
P
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
K
-
Q
E
T
L
A
N
V
S
A
V
-
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
-
K
P
P
Q
F
E
-----------------------------
64
PsiBlast_CBE
78.78
39%
-120
- C1 -
1QL6
1
PHKG1_RABIT
A:
[17-288]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
N
Y
E
P
K
E
I
L
G
R
G
V
S
S
V
V
R
R
C
I
H
K
P
T
C
K
E
Y
A
V
K
I
I
D
V
-----
T
GGGSFS
A
E
E
V
Q
E
------
L
--
R
-
E
----
A
-
T
L
K
E
V
D
I
L
R
K
V
S
G
H
P
N
I
I
Q
L
K
D
T
Y
E
T
N
T
F
F
F
L
V
F
D
L
M
K
K
G
E
L
F
D
Y
L
T
E
K
V
-------------------------------
T
L
--------
S
E
K
E
T
R
K
I
M
R
A
L
L
E
V
I
C
A
L
H
K
L
N
I
V
H
R
D
L
K
P
E
N
-
I
L
L
----
D
D
D
M
N
I
K
L
T
D
F
G
F
S
C
Q
--
L
D
P---
G
-----
E
----
K
---
L
---
R
-
S
V
C
G
T
P
S
Y
L
A
P
E
I
I
E
C
S
M
N
D
N
H
P
--
G
Y
-
G
K
E
V
D
M
W
S
T
G
V
I
M
Y
T
L
L
A
G
S
P
P
F
W
--
H
R
K
Q
M
L
M
L
R
M
I
M
S
G
N
Y
Q
F
G
S
P
E
W
D
D
Y
S
D
T
V
K
D
L
V
S
R
F
L
V
V
Q
P
Q
K
R
Y
T
A
E
E
A
L
A
H
P
F
F
-
Q
Q
Y
V
-------------------------------
131
HHSearch
78.63
41%
-119
- C1 -
3SOA
1
KCC2A_HUMAN
A:
[7-273]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
R
F
T
E
E
Y
Q
L
F
E
E
L
G
K
G
--
S
V
V
R
R
C
V
K
V
L
A
G
Q
E
Y
A
A
M
I
I
N
T
-----
K
--------
K
L
S
A
------
R
D
-
H
-
Q
----
K
-
L
E
R
E
A
R
I
C
R
L
L
K
-
H
P
N
I
V
R
L
H
D
S
I
S
E
E
G
H
H
Y
L
I
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
E
-------------------------------
Y
Y
--------
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
A
V
L
H
C
H
Q
M
G
V
V
H
R
N
L
K
P
E
N
-
L
L
L
A
S
K
L
K
-
G
A
A
V
K
L
A
D
F
G
L
A
I
E
--
V
-----
E
-----
G
----
E
Q
Q
A
W
---
F
-
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
------
R
K
D
--
P
Y
-
G
K
P
V
D
L
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
D
--
E
D
Q
H
R
L
Y
Q
Q
I
K
A
G
A
Y
D
F
P
S
P
E
W
D
T
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
S
K
R
I
T
A
A
E
A
L
K
H
P
W
I
-
S
H
R
S
T
V
A
S
C
M
H
R
Q
E
T
V
D
C
L
K
K
F
N
A
R
R
K
L
K
G
A
I
L
T
V
29
PsiBlast_CBE
78.60
43%
-112
- C1 -
3F5U
1
DAPK1_HUMAN
A:
[8-275]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
V
D
D
Y
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
-----
R
--------
R
T
K
S
SRRGVS
R
--
E
-
D
------
I
E
R
E
V
S
I
L
K
E
I
Q
-
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
E
-------------------------------
S
L
--------
T
E
E
E
A
T
E
F
-
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
-
R
I
K
I
I
D
F
G
L
A
H
K
--
I
DFGNE
F
-----
K
----
N
---
I
---
F
----
G
T
P
E
F
V
A
P
E
I
V
------
N
Y
E
--
P
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
K
-
Q
E
T
L
A
N
V
S
A
V
-
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
-
K
P
P
Q
F
E
-----------------------------
42
PsiBlast_CBE
78.57
43%
-116
- C1 -
1JKL
1
DAPK1_HUMAN
A:
[7-274]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
V
D
D
Y
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
-----
R
--------
R
T
K
S
SRRGVS
R
--
E
-
D
------
I
E
R
E
V
S
I
L
K
E
I
Q
-
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
E
-------------------------------
S
L
--------
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
-
R
I
K
I
I
D
F
G
L
A
H
K
--
I
DFGNE
F
-----
K
----
N
---
I
---
F
----
G
T
P
E
F
V
A
P
E
I
V
------
N
Y
E
--
P
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
K
-
Q
E
T
L
A
N
V
S
A
V
-
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
-
K
P
P
Q
F
E
-----------------------------
94
PsiBlast_CBE
78.50
36%
-123
- C1 -
2Y7J
1
PHKG2_HUMAN
A:
[82-364]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ELP
D
W
A
A
-
A
K
E
F
Y
Q
K
Y
D
P
K
D
V
I
G
R
G
V
S
S
V
V
R
R
C
V
H
R
A
T
G
H
E
F
A
V
K
I
M
E
V
-----
T
A
E
R
L
S
P
E
-
Q
L
E
E
------
V
--
R
-
E
----
A
-
T
R
R
E
T
H
I
L
R
Q
V
A
G
H
P
H
I
I
T
L
I
D
S
Y
E
S
S
S
F
M
F
L
V
F
D
L
M
R
K
G
E
L
F
D
Y
L
T
E
K
V
-------------------------------
A
L
--------
S
E
K
E
T
R
S
I
M
R
S
L
L
E
A
V
S
F
L
H
A
N
N
I
V
H
R
D
L
K
P
E
N
-
I
L
L
----
D
D
N
M
Q
I
R
L
S
D
F
G
F
S
C
H
--
L
-----
E
P
G---
E
----
K
---
L
---
R
-
E
L
C
G
T
P
G
Y
L
A
P
E
I
L
K
C
S
M
D
E
T
H
P
--
G
Y
-
G
K
E
V
D
L
W
A
C
G
V
I
L
F
T
L
L
A
G
S
P
P
F
W
--
H
R
R
Q
I
L
M
L
R
M
I
M
E
G
Q
Y
Q
F
S
S
P
E
W
D
D
R
S
S
T
V
K
D
L
I
S
R
L
L
Q
V
D
P
E
A
R
L
T
A
E
Q
A
L
Q
H
P
F
F
-
E
R
---------------------------------
49
PsiBlast_CBE
78.34
43%
-116
- C1 -
3GU7
1
DAPK1_HUMAN
A:
[8-275]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
V
D
D
Y
Y
D
T
G
E
E
L
G
S
G
V
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
-----
R
--------
R
T
K
S
SRRGVS
R
--
E
-
D
------
I
E
R
E
V
S
I
L
K
E
I
Q
-
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
E
-------------------------------
S
L
--------
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
-
R
I
K
I
I
D
F
G
L
A
H
K
--
I
DFGNE
F
-----
K
----
N
---
I
---
F
----
G
T
P
E
F
V
A
P
E
I
V
------
N
Y
E
--
P
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
K
-
Q
E
T
L
A
N
V
S
A
V
-
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
-
K
P
P
Q
F
E
-----------------------------
93
PsiBlast_CBE
78.30
36%
-122
- C1 -
2Y7J
1
PHKG2_HUMAN
C:
[82-364]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ELPDW
A
A
-
A
K
E
F
Y
Q
K
Y
D
P
K
D
V
I
G
R
G
V
S
S
V
V
R
R
C
V
H
R
A
T
G
H
E
F
A
V
K
I
M
E
V
-----
T
AERLSPE-
Q
L
E
E
------
V
--
R
-
E
----
A
-
T
R
R
E
T
H
I
L
R
Q
V
A
G
H
P
H
I
I
T
L
I
D
S
Y
E
S
S
S
F
M
F
L
V
F
D
L
M
R
K
G
E
L
F
D
Y
L
T
E
K
V
-------------------------------
A
L
--------
S
E
K
E
T
R
S
I
M
R
S
L
L
E
A
V
S
F
L
H
A
N
N
I
V
H
R
D
L
K
P
E
N
-
I
L
L
----
D
D
N
M
Q
I
R
L
S
D
F
G
F
S
C
H
--
L
-----
E
PG---
E
----
K
---
L
---
R
-
E
L
C
G
T
P
G
Y
L
A
P
E
I
L
KCSMDE
T
H
P
--
G
Y
-
G
K
E
V
D
L
W
A
C
G
V
I
L
F
T
L
L
A
G
S
P
P
F
W
--
H
R
R
Q
I
L
M
L
R
M
I
M
E
G
Q
Y
Q
F
S
S
P
E
W
D
D
R
S
S
T
V
K
D
L
I
S
R
L
L
Q
V
D
P
E
A
R
L
T
A
E
Q
A
L
Q
H
P
F
F
-
E
R
---------------------------------
51
PsiBlast_CBE
78.21
43%
-115
- C1 -
3GU5
1
DAPK1_HUMAN
A:
[8-275]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
V
D
D
Y
Y
D
T
G
E
E
L
G
S
G
V
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
-----
R
--------
R
T
K
S
SRRGVS
R
--
E
-
D
------
I
E
R
E
V
S
I
L
K
E
I
Q
-
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
E
-------------------------------
S
L
--------
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
-
R
I
K
I
I
D
F
G
L
A
H
K
--
I
DFGNE
F
-----
K
----
N
---
I
---
F
----
G
T
P
E
F
V
A
P
E
I
V
------
N
Y
E
--
P
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
K
-
Q
E
T
L
A
N
V
S
A
V
-
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
-
K
P
P
Q
F
E
-----------------------------
57
PsiBlast_CBE
78.12
43%
-118
- C1 -
3GU8
1
DAPK1_HUMAN
A:
[8-275]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
V
D
D
Y
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
-----
R
--------
R
T
K
S
SRRGVS
R
--
E
-
D
------
I
E
R
E
V
S
I
L
K
E
I
Q
-
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
G
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
E
-------------------------------
S
L
--------
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
-
R
I
K
I
I
D
F
G
L
A
H
K
--
I
DFGNE
F
-----
K
----
N
---
I
---
F
----
G
T
P
E
F
V
A
P
E
I
V
------
N
Y
E
--
P
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
K
-
Q
E
T
L
A
N
V
S
A
V
-
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
-
K
P
Q
F
-------------------------------
41
PsiBlast_CBE
78.12
43%
-116
- C1 -
3EH9
1
DAPK1_HUMAN
A:
[7-274]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
V
D
D
Y
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
-----
R
--------
R
T
K
S
SRGVS-
R
--
E
-
D
------
I
E
R
E
V
S
I
L
K
E
I
Q
-
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
--------------------------------
S
L
--------
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
-
R
I
K
I
I
D
F
G
L
A
H
K
--
I
DFGNE
F
-----
K
----
N
---
I
---
F
----
G
T
P
E
F
V
A
P
E
I
V
------
N
Y
E
--
P
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
K
-
Q
E
T
L
A
N
V
S
A
V
-
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
-
K
P
P
Q
F
E
-----------------------------
136
HHSearch
78.01
38%
-125
- C1 -
4BKY
1
MELK_HUMAN
A:
[6-267]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
E
L
L
K
Y
Y
E
L
H
E
T
I
G
T
G
G
F
A
K
V
K
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
M
D
K
-----
N
--------
T
L
--------
D
--
L
-
P
----
R
-
I
K
T
E
I
E
A
L
K
N
L
R
-
H
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
D
-------------------------------
R
L
--------
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
-
L
L
F
D
----
E
Y
H
K
L
K
L
I
D
F
G
L
C
A
----------------------------------
S
L
A
Y
A
A
P
E
L
I
------
Q
G
K
-----
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
D
D
--
D
N
V
M
A
L
Y
K
K
I
M
R
G
K
Y
D
V
P
--
K
W
--
L
S
P
S
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
S
M
K
N
L
L
N
H
P
W
I
-
M
Q
D
Y
N
Y
P
V
E
W
Q
S
K
N
P
F
I
H
L
D
D
D
C
V
T
E
L
S
V
H
H
R
N
N
R
69
PsiBlast_CBE
77.91
39%
-123
- C1 -
1PHK
1
PHKG1_RABIT
A:
[17-288]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
N
Y
E
P
K
E
I
L
G
R
G
V
S
S
V
V
R
R
C
I
H
K
P
T
C
K
E
Y
A
V
K
I
I
D
V
-----
T
GGGSFS
A
E
E
V
Q
E
------
L
--
R
-
E
----
A
-
T
L
K
E
V
D
I
L
R
K
V
S
G
H
P
N
I
I
Q
L
K
D
T
Y
E
T
N
T
F
F
F
L
V
F
D
L
M
K
K
G
E
L
F
D
Y
L
T
E
K
V
-------------------------------
T
L
--------
S
E
K
E
T
R
K
I
M
R
A
L
L
E
V
I
C
A
L
H
K
L
N
I
V
H
R
D
L
K
P
E
N
-
I
L
L
----
D
D
D
M
N
I
K
L
T
D
F
G
F
S
C
Q
--
L
D
P---
G
-----
E
----
K
---
L
---
R
-
E
V
C
G
T
P
S
Y
L
A
P
E
I
I
E
C
S
M
N
D
N
H
P
--
G
Y
-
G
K
E
V
D
M
W
S
T
G
V
I
M
Y
T
L
L
A
G
S
P
P
F
W
--
H
R
K
Q
M
L
M
L
R
M
I
M
S
G
N
Y
Q
F
G
S
P
E
W
D
D
Y
S
D
T
V
K
D
L
V
S
R
F
L
V
V
Q
P
Q
K
R
Y
T
A
E
E
A
L
A
H
P
F
F
-
Q
Q
Y
V
-------------------------------
10
PsiBlast_PDB
77.90
43%
-116
- C1 -
2XUU
1
DAPK1_HUMAN
A:
[8-275]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
V
D
D
Y
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
-----
R
--------
R
T
K
S
SRRGVS
R
--
E
-
D
------
I
E
R
E
V
S
I
L
K
E
I
Q
-
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
E
-------------------------------
S
L
--------
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
-
R
I
K
I
I
D
F
G
L
A
H
K
--
I
DFG
N
E
F
-----
K
----
N
---
I
---
F
----
G
T
P
A
F
V
A
P
E
I
V
------
N
Y
E
--
P
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
K
-
Q
E
T
L
A
N
V
S
A
V
-
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
-
K
P
K
D
T
Q
Q
A
L
S
R
K
A
S
A
V
N
M
E
K
F
K
K
F
A
A
R
--------
54
PsiBlast_CBE
77.86
40%
-110
- C1 -
2V7O
3
KCC2G_HUMAN
A:
[33-307]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
Q
L
F
E
E
L
G
K
G
-
F
S
V
V
R
R
C
V
K
K
T
P
T
Q
E
Y
A
A
K
I
I
N
T
-----
K
--------
K
L
S
A
------
R
--
D
-
H
----
Q
K
L
E
R
E
A
R
I
C
R
L
L
K
-
H
P
N
I
V
R
L
H
D
S
I
S
E
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
E
-------------------------------
Y
Y
--------
S
E
A
D
A
S
H
C
I
H
Q
I
L
E
S
V
N
H
I
H
Q
H
D
I
V
H
R
D
L
K
P
E
N
-
L
L
L
A
-
S
K
C
K
G
A
A
V
K
L
A
D
F
G
L
A
I
E
--
V
QGE--
Q
-----
Q
----
A
---
W
---
F
-
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
------
R
K
D
--
P
Y
-
G
K
P
V
D
I
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
--
D
E
D
Q
H
K
L
Y
Q
Q
I
K
A
G
A
Y
D
F
P
S
P
E
W
D
T
V
T
P
E
A
K
N
L
I
N
Q
M
L
T
I
N
P
A
K
R
I
T
A
D
Q
A
L
K
H
P
W
V
C
Q
R
S
T
V
A
S
M
M
H
R
Q
E
T
V
E
C
L
R
K
F
N
A
R
R
K
L
K
G
------
12
PsiBlast_PDB
77.78
43%
-118
- C1 -
4B4L
3
DAPK1_HUMAN
A:
[10-277]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
V
D
D
Y
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
-----
R
--------
R
T
K
S
SRRGVS
R
--
E
-
D
------
I
E
R
E
V
S
I
L
K
E
I
Q
-
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
E
-------------------------------
S
L
--------
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
-
R
I
K
I
I
D
F
G
L
A
H
K
--
I
DFG
N
E
F
-----
K
----
N
---
I
---
F
----
G
T
P
E
F
V
A
P
E
I
V
------
N
Y
E
--
P
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
K
-
Q
E
T
L
A
N
V
S
A
V
-
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
-
K
P
K
D
T
Q
Q
A
L
S
R
K
A
S
A
V
N
M
E
K
F
K
K
F
A
A
A
K
-------
135
HHSearch
77.55
38%
-124
- C1 -
3LIJ
1
?
A:
[33-297]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
H
L
S
E
M
Y
Q
R
V
K
K
L
G
S
---
G
E
V
L
L
C
R
D
K
V
T
H
V
E
R
A
I
K
I
I
R
K
-----------------
S
------
S
--
N
-
S
----
K
-
L
L
E
E
V
A
V
L
K
L
L
D
-
H
P
N
I
M
K
L
Y
D
F
F
E
D
K
R
N
Y
Y
L
V
M
E
C
Y
K
G
G
E
L
F
D
E
I
I
H
R
M
-------------------------------
K
F
--------
N
E
V
D
A
A
V
I
I
K
Q
V
L
S
G
V
T
Y
L
H
K
H
N
I
V
H
R
D
L
K
P
E
N
-
L
L
L
E
S
K
E
-
K
D
A
L
I
K
I
V
D
F
G
L
S
A
V
--
F
-----
E
-----
N
Q
K
--
K
---
M
---
K
-
E
R
L
G
T
A
Y
Y
I
A
P
E
V
L
------
R
K
---
K
Y
-
D
E
K
C
D
V
W
S
I
G
V
I
L
F
I
L
L
A
G
Y
P
P
F
G
G
--
Q
T
D
Q
E
I
L
R
K
V
E
K
G
K
Y
T
F
D
S
P
E
W
K
N
V
S
E
G
A
K
D
L
I
K
Q
M
L
Q
F
D
S
Q
R
R
I
S
A
Q
Q
A
L
E
H
P
W
I
-
K
E
M
C
S
K
K
E
S
L
P
S
L
A
N
A
I
E
N
M
R
K
F
Q
N
S
Q
K
L
A
Q
A
A
L
L
52
PsiBlast_CBE
77.54
43%
-114
- C1 -
3GU4
1
DAPK1_HUMAN
A:
[8-275]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
V
D
D
Y
Y
D
T
G
E
E
L
G
S
G
V
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
-----
R
--------
R
T
K
S
SRRGVS
R
--
E
-
D
------
I
E
R
E
V
S
I
L
K
E
I
Q
-
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
E
-------------------------------
S
L
--------
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
-
R
I
K
I
I
D
F
G
L
A
H
K
--
I
DFG
N
E
F
-----
K
----
N
---
I
---
F
----
G
T
P
E
F
V
A
P
E
I
V
------
N
Y
E
--
P
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
K
-
Q
E
T
L
A
N
V
S
A
V
-
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
-
K
P
P
Q
F
E
-----------------------------
45
PsiBlast_CBE
77.52
43%
-116
- C1 -
1P4F
1
DAPK1_HUMAN
A:
[7-274]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
V
D
D
Y
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
-----
R
--------
R
T
K
S
SRRGVS
R
--
E
-
D
------
I
E
R
E
V
S
I
L
K
E
I
Q
-
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
----------------------------------------------
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
---
R
I
K
I
I
D
F
G
L
A
H
K
--
I
DFGNE
F
-----
K
----
N
---
I
---
F
----
G
T
P
E
F
V
A
P
E
I
V
------
N
Y
E
--
P
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
K
-
Q
E
T
L
A
N
V
S
A
V
-
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
-
K
P
Q
F
-------------------------------
16
PsiBlast_PDB
77.34
43%
-115
- C1 -
2W4K
1
DAPK1_HUMAN
A:
[8-275]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
V
D
D
Y
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
-----
R
--------
R
T
K
S
SRRGVS
R
--
E
-
D
------
I
E
R
E
V
S
I
L
K
E
I
Q
-
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
E
-------------------------------
S
L
--------
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
-
R
I
K
I
I
D
F
G
L
A
H
K
--
I
DFG
N
E
F
-----
K
----
N
---
I
---
F
----
G
T
P
E
F
V
A
P
E
I
V
------
N
Y
E
--
P
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
K
-
Q
E
T
L
A
N
V
S
A
V
-
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
-
K
P
K
D
T
Q
Q
A
L
S
R
K
A
S
A
V
N
M
E
K
F
K
K
F
A
A
R
--------
30
PsiBlast_CBE
76.91
43%
-123
- C1 -
3ZXT
1
DAPK1_HUMAN
D:
[8-275]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
V
D
D
Y
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
--------------------VS----
R
--
E
-
D
------
I
E
R
E
V
S
I
L
K
E
I
Q
-
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
-------------------------------------------
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
-
R
I
K
I
I
D
F
G
L
A
H
K
--
I
D-----------------------------
T
P
E
F
V
A
P
E
I
V
------
N
Y
E
--
P
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
K
-
Q
E
T
L
A
N
V
S
A
V
-
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
-
K
----------------------------------
33
PsiBlast_CBE
75.71
43%
-113
- C1 -
3ZXT
1
DAPK1_HUMAN
A:
[8-275]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
V
D
D
Y
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
-----
R
--------
R
T
--------
R
--
E
-
D
------
I
E
R
E
V
S
I
L
K
E
I
Q
-
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
E
-------------------------------
S
L
--------
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
-
V
P
K
P
-
R
I
K
I
I
D
F
G
L
A
H
K
--
I
D-------------------------------
E
F
V
A
P
E
I
V
------
N
Y
E
--
P
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
K
-
Q
E
T
L
A
N
V
S
A
V
-
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
-
K
----------------------------------
6
PsiBlast_PDB
75.11
43%
-113
- C1 -
4FG8
1
KCC1A_HUMAN
A:
[13-288]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
E
D
I
R
D
I
Y
D
F
R
D
V
L
G
T
G
A
F
S
E
V
I
L
A
E
D
K
R
T
Q
K
L
V
A
I
K
C
I
A
K
-----
E
--------------------------------
N
E
I
A
V
L
H
K
I
K
-
H
P
N
I
V
A
L
D
D
I
Y
E
S
G
G
H
L
Y
L
I
M
Q
L
V
S
G
G
E
L
F
D
R
I
V
E
K
G
-------------------------------
F
Y
--------
T
E
R
D
A
S
R
L
I
F
Q
V
L
D
A
V
K
Y
L
H
D
L
G
I
V
H
R
D
L
K
P
E
N
-
L
L
-
Y
Y
S
L
D
E
D
S
K
I
M
I
S
D
F
--------------------------------------
T
P
G
Y
V
A
P
E
V
L
------
A
Q
K
--
P
Y
-
S
K
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
Y
--
D
E
N
D
A
K
L
F
E
Q
I
L
K
A
E
Y
E
F
D
S
P
Y
W
D
D
I
S
D
S
A
K
D
F
I
R
H
L
M
E
K
D
P
E
K
R
F
T
C
E
Q
A
L
Q
H
P
W
I
---
A
G
D
T
A
L
D
K
N
I
H
Q
S
V
S
E
Q
I
K
K
N
F
A
----------
23
PsiBlast_CBE
75.10
43%
-113
- C1 -
4FG8
1
KCC1A_HUMAN
B:
[14-288]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
I
R
D
I
Y
D
F
R
D
V
L
G
T
G
A
F
S
E
V
I
L
A
E
D
K
R
T
Q
K
L
V
A
I
K
C
I
A
K
--------------------------------------
N
E
I
A
V
L
H
K
I
K
-
H
P
N
I
V
A
L
D
D
I
Y
E
S
G
G
H
L
Y
L
I
M
Q
L
V
S
G
G
E
L
F
D
R
I
V
E
K
G
-------------------------------
F
Y
--------
T
E
R
D
A
S
R
L
I
F
Q
V
L
D
A
V
K
Y
L
H
D
L
G
I
V
H
R
D
L
K
P
E
N
-
L
L
-
Y
Y
S
L
D
E
D
S
K
I
M
I
S
D
F
G
------------------------G
S
V
L
---
S
-
T
A
C
G
T
P
G
Y
V
A
P
E
V
L
------
A
Q
K
--
P
Y
-
S
K
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
Y
--
D
E
N
D
A
K
L
F
E
Q
I
L
K
A
E
Y
E
F
D
S
P
Y
W
D
D
I
S
D
S
A
K
D
F
I
R
H
L
M
E
K
D
P
E
K
R
F
T
C
E
Q
A
L
Q
H
P
W
I
---
A
G
D
T
A
L
D
K
N
I
H
Q
S
V
S
E
Q
I
K
K
N
F
A
----------
31
PsiBlast_CBE
75.03
43%
-118
- C1 -
3ZXT
1
DAPK1_HUMAN
C:
[8-275]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
V
D
D
Y
Y
D
T
G
E
E
L
G
--
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
-----
R
--------
R
T
K
S
SRRGVS
R
--
E
-
D
------
I
E
R
E
V
S
I
L
K
E
I
Q
-
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
E
-------------------------------
S
L
--------
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
-
R
I
K
I
I
D
F
G
L
A
H
K
--
I
D------------------------------
P
E
F
V
A
P
E
I
V
------
N
Y
E
--
P
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
K
-
Q
E
T
L
A
N
V
S
A
V
-
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
-
K
----------------------------------
142
HHSearch
74.86
39%
-115
- C1 -
3NYV
1
?
A:
[22-288]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
I
F
S
D
R
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
K
-----
R
--------
Q
V
K
Q
------
K
TD
K
-
E
----
S
-
L
L
R
E
V
Q
L
L
K
Q
L
D
-
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
-------------------------------
R
F
--------
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
-
L
L
L
E
S
K
S
-
K
D
A
N
I
R
I
I
D
F
G
L
S
T
H
--
F
-----
E
-----
A
S
K--
K
---
M
---
K
-
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
------
H
G
---
T
Y
-
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
--
A
N
E
Y
D
I
L
K
K
V
E
K
G
K
Y
T
F
E
L
P
Q
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
A
R
D
A
L
D
H
E
W
I
-
Q
T
Y
T
K
D
V
P
S
L
D
N
A
I
L
N
I
R
Q
F
Q
G
T
Q
K
L
A
Q
A
A
L
L
Y
M
G
81
PsiBlast_CBE
74.65
37%
-100
- C1 -
2YAA
1
DAPK2_MOUSE
A:
[10-302]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
E
D
F
Y
D
I
G
E
E
L
G
S
G
Q
F
A
I
V
K
K
C
R
E
K
S
T
G
L
E
Y
A
A
K
F
I
K
K
R
QSRA
S
--------
R
R
G
V
------
C
--
R
-
E
----
E
-
I
E
R
E
V
S
I
L
R
Q
V
L
-
H
P
N
I
I
T
L
H
D
V
Y
E
N
R
T
D
V
V
L
I
L
E
L
V
S
G
G
E
L
F
D
F
L
A
Q
K
E
-------------------------------
S
L
--------
S
E
E
E
A
T
S
F
I
K
Q
I
L
D
G
V
N
Y
L
H
T
K
K
I
A
H
F
D
L
K
P
E
N
-
I
M
L
L
D
K
N
I
P
I
P
H
I
K
L
I
D
F
G
L
A
H
E
--
I
E
D
G
V
E
F
-----
K
----
N
---
I
---
F
----
G
T
P
E
F
V
A
P
E
I
V
------
N
Y
E
--
P
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
K
-
Q
E
T
L
A
N
I
T
A
V
S
-
Y
D
F
D
E
E
F
F
S
Q
T
S
E
L
A
K
D
F
I
R
K
L
L
V
K
E
T
R
K
R
L
T
I
Q
E
A
L
R
H
P
W
I
-
T
P
V
D
T
Q
Q
A
M
V
R
R
E
S
V
V
N
L
E
--
N
F
K
K
Q
Y
V
-------
84
PsiBlast_CBE
74.56
38%
-125
- C1 -
3HX4
3
?
A:
[52-314]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
K
-----------------------------
D
K
E
--
S
-
L
L
R
E
V
Q
L
L
K
Q
L
D
-
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
-------------------------------
R
F
--------
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
-
L
L
L
E
-
S
K
S
K
D
A
N
I
R
I
I
D
F
G
L
S
T
H
--
F
E
A---
S
-----
K
----
K
---
M
---
K
-
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
-------
H
G
--
T
Y
-
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
A
--
N
E
Y
D
I
L
K
K
V
E
K
G
K
Y
T
F
E
L
P
Q
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
A
R
D
A
L
D
H
E
W
I
-
Q
T
Y
T
K
E
Q
I
S
V
D
V
P
S
L
D
N
A
I
L
N
I
R
Q
F
Q
G
T
Q
K
L
A
Q
A
A
8
PsiBlast_PDB
74.52
43%
-122
- C1 -
2JAM
3
KCC1G_HUMAN
A:
[6-266]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
I
R
K
T
F
I
F
M
E
V
L
G
S
G
A
F
S
E
V
F
L
V
K
Q
R
L
T
G
K
L
F
A
L
K
C
I
K
K
-----
S
----------------------------
S
-
L
E
N
E
I
A
V
L
K
K
I
K
-
H
E
N
I
V
T
L
E
D
I
Y
E
S
T
T
H
Y
Y
L
V
M
Q
L
V
S
G
G
E
L
F
D
R
I
L
E
R
G
-------------------------------
V
Y
--------
T
E
K
D
A
S
L
V
I
Q
Q
V
L
S
A
V
K
Y
L
H
E
N
G
I
V
H
R
D
L
K
P
E
N
-
L
L
Y
L
T
P
E
E
N
S
K
I
M
-
I
T
D
F
G
L
S
K
M
--
E
-----
Q
-----
N
----
G
---
I
---
M
S
T
A
C
G
T
P
G
Y
V
A
P
E
V
L
------
A
Q
K
--
P
Y
-
S
K
A
V
D
C
W
S
I
G
V
I
T
Y
I
L
L
C
G
Y
P
P
F
Y
--
E
E
T
E
S
K
L
F
E
K
I
K
E
G
Y
Y
E
F
E
S
P
F
W
D
D
I
S
E
S
A
K
D
F
I
C
H
L
L
E
K
D
P
N
E
R
Y
T
C
E
K
A
L
S
H
P
W
I
-
D
G
N
T
A
L
H
R
D
I
Y
P
S
V
S
L
Q
I
Q
K
N
F
A
K
S
----------
80
PsiBlast_CBE
74.22
37%
-99
- C1 -
2YAA
1
DAPK2_MOUSE
B:
[10-302]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
E
D
F
Y
D
I
G
E
E
L
G
S
G
Q
F
A
I
V
K
K
C
R
E
K
S
T
G
L
E
Y
A
A
K
F
I
K
K
RQSRA
S
--------
R
R
G
V
------
C
--
R
-
E
----
E
-
I
E
R
E
V
S
I
L
R
Q
V
L
-
H
P
N
I
I
T
L
H
D
V
Y
E
N
R
T
D
V
V
L
I
L
E
L
V
S
G
G
E
L
F
D
F
L
A
Q
K
E
-------------------------------
S
L
--------
S
E
E
E
A
T
S
F
I
K
Q
I
L
D
G
V
N
Y
L
H
T
K
K
I
A
H
F
D
L
K
P
E
N
-
I
M
L
L
D
K
N
I
P
I
P
H
I
K
L
I
D
F
G
L
A
H
E
--
I
E
DG
V
E
F
-----
K
----
N
---
I
---
F
----
G
T
P
E
F
V
A
P
E
I
V
------
N
Y
E
--
P
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
K
-
Q
E
T
L
A
N
I
T
A
V
S
-
Y
D
F
D
E
E
F
F
S
Q
T
S
E
L
A
K
D
F
I
R
K
L
L
V
K
E
T
R
K
R
L
T
I
Q
E
A
L
R
H
P
W
I
-
T
P
V
D
T
Q
Q
A
M
V
R
R
E
S
V
V
N
L
E
--
N
F
K
K
Q
Y
V
-------
4
PsiBlast_PDB
74.16
43%
-109
- C1 -
4FG9
1
KCC1A_HUMAN
A:
[13-288]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
E
D
I
R
D
I
Y
D
F
R
D
V
L
G
T
G
A
F
S
E
V
I
L
A
E
D
K
R
T
Q
K
L
V
A
I
K
C
I
A
K
-----
E
-------------------------------
E
N
E
I
A
V
L
H
K
I
K
-
H
P
N
I
V
A
L
D
D
I
Y
E
S
G
G
H
L
Y
L
I
M
Q
L
V
S
G
G
E
L
F
D
R
I
V
E
K
G
-------------------------------
F
Y
--------
T
E
R
D
A
S
R
L
I
F
Q
V
L
D
A
V
K
Y
L
H
D
L
G
I
V
H
R
D
L
K
P
E
N
-
L
L
-
Y
Y
S
L
D
E
D
S
K
I
M
I
S
D
F
---------------------------------------
P
G
Y
V
A
P
E
V
L
------
A
Q
K
--
P
Y
-
S
K
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
Y
--
D
E
N
D
A
K
L
F
E
Q
I
L
K
A
E
Y
E
F
D
S
P
Y
W
D
D
I
S
D
S
A
K
D
F
I
R
H
L
M
E
K
D
P
E
K
R
F
T
C
E
Q
A
L
Q
H
P
W
I
---
A
G
D
T
A
L
D
K
N
I
H
Q
S
V
S
E
Q
I
K
K
N
F
A
K
S
K
W
K
Q
A
F
N
A
87
PsiBlast_CBE
74.10
38%
-115
- C1 -
3KU2
1
?
A:
[51-313]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
K
-----
R
--------
Q
V
K
Q
------
K
--
T
-
D
K
E
--
S
-
L
L
R
E
V
Q
L
L
K
Q
L
D
-
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
-------------------------------
R
F
--------
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
-
L
L
L
E
-
S
K
S
K
D
A
N
I
R
I
I
D
F
G
L
S
T
H
--
F
EA---
S
-----
K
----
K
---
M
---
K
-
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
-------
H
G
--
T
Y
-
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
A
--
N
E
Y
D
I
L
K
K
V
E
K
G
K
Y
T
F
E
L
P
Q
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
A
R
D
A
L
D
H
E
W
I
-
Q
T
Y
T
K
E
Q
I
S
V
D
V
P
S
L
D
N
A
I
L
N
I
R
Q
F
Q
G
T
Q
K
L
A
Q
A
A
32
PsiBlast_CBE
73.86
43%
-113
- C1 -
3ZXT
1
DAPK1_HUMAN
B:
[8-275]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
V
D
D
Y
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
-----
R
--------
R
T
K
S
RRGVS-
R
--
E
-
D
------
I
E
R
E
V
S
I
L
K
E
I
Q
-
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
---------------------------------
L
--------
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
-
R
I
K
I
I
D
F
G
L
A
H
K
--
I
D-----------------------------
T
P
E
F
V
A
P
E
I
V
------
N
Y
E
--
P
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
-
S
G
A
S
P
F
L
G
D
T
K
-
Q
E
T
L
A
N
V
S
A
V
-
N
Y
E
F
E
D
E
Y
F
S
---
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
-
K
----------------------------------
22
PsiBlast_CBE
73.65
43%
-113
- C1 -
4FG9
1
KCC1A_HUMAN
B:
[14-288]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
I
R
D
I
Y
D
F
R
D
V
L
G
T
G
A
F
S
E
V
I
L
A
E
D
K
R
T
Q
K
L
V
A
I
K
C
I
A
K
---------------------------------------
E
I
A
V
L
H
K
I
K
-
H
P
N
I
V
A
L
D
D
I
Y
E
S
G
G
H
L
Y
L
I
M
Q
L
V
S
G
G
E
L
F
D
R
I
V
E
K
G
-------------------------------
F
Y
--------
T
E
R
D
A
S
R
L
I
F
Q
V
L
D
A
V
K
Y
L
H
D
L
G
I
V
H
R
D
L
K
P
E
N
-
L
L
-
Y
Y
S
L
D
E
D
S
K
I
M
I
S
D
F
-------------------------V--
L
---
S
-
T
A
C
G
T
P
G
Y
V
A
P
E
V
L
------
A
Q
K
--
P
Y
-
S
K
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
Y
--
D
E
N
D
A
K
L
F
E
Q
I
L
K
A
E
Y
E
F
D
S
P
Y
W
D
D
I
S
D
S
A
K
D
F
I
R
H
L
M
E
K
D
P
E
K
R
F
T
C
E
Q
A
L
Q
H
P
W
I
---
A
G
D
T
A
L
D
K
N
I
H
Q
S
V
S
E
Q
I
K
K
N
F
A
K
S
K
W
K
Q
A
F
N
A
112
PsiBlast_CBE
72.92
36%
-131
- C1 -
4BDB
10
CHK2_HUMAN
A:
[7-285]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
S
-----
V
Y
-
P
K
A
L
R
D
E
Y
I
M
S
K
T
L
------
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
------------------------------L---
N
-
V
E
T
E
I
E
I
L
K
K
L
N
-
H
P
C
I
I
K
I
K
N
F
F
D
A
E
-
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
-------------------------------
R
L
--------
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
-
V
L
L
S
S
Q
E
E
-
D
C
L
I
K
I
T
D
F
G
H
S
K
I
--
L
E----
T
-----
S
----
L
---
M
---
R
-
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V---
G
T
A
--
G
Y
-
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
-
S
E
H
R
T
Q
V
S
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
-
Q
D
E
D
M
K
R
K
F
Q
D
L
L
S
E
E
N
E
S
T
A
L
P
Q
V
L
A
--------
127
HHSearch
72.81
38%
-118
- C1 -
3C0I
1
CSKP_HUMAN
A:
[21-293]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
F
E
D
V
Y
E
L
C
E
V
I
G
K
G
P
F
S
V
V
R
R
C
I
N
R
E
T
G
Q
Q
F
A
V
K
I
V
D
V
-----
A
--------
K
F
T
S
SPGL--
S
--
T
-
E
----
D
-
L
K
R
E
A
S
I
C
H
M
L
K
-
H
P
H
I
V
E
L
L
E
T
Y
S
S
D
G
M
L
Y
M
V
F
E
F
M
D
G
A
D
L
C
F
E
I
V
K
R
A
D
A
G
F
---------------------------
V
Y
--------
S
E
A
V
A
S
H
Y
M
R
Q
I
L
E
A
L
R
Y
C
H
D
N
N
I
I
H
R
D
V
K
P
H
C
-
V
L
L
A
S
K
E
-
N
S
A
P
V
K
L
G
G
F
G
V
A
I
Q
--
L
-----
G
-----
E
----
S
---
G
LV
A
G
-
G
R
V
G
T
P
H
F
M
A
P
E
V
V
------
K
R
E
--
P
Y
-
G
K
P
V
D
V
W
G
C
G
V
I
L
F
I
L
L
S
G
C
L
P
F
Y
G
---
T
K
E
R
L
F
E
G
I
I
K
G
K
Y
K
M
N
P
R
Q
W
S
H
I
S
E
S
A
K
D
L
V
R
R
M
L
M
L
D
P
A
E
R
I
T
V
Y
E
A
L
N
H
P
W
L
-
K
E
R
D
R
Y
A
Y
K
I
H
L
P
E
T
V
E
Q
L
R
K
F
N
A
R
R
K
--------
100
PsiBlast_CBE
72.81
36%
-123
- C1 -
2YCQ
1
CHK2_HUMAN
A:
[3-279]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
Y
-
P
K
A
L
R
D
E
Y
I
M
S
K
T
L
G
S
G
A
C
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
----------------------------------
N
-
V
E
T
E
I
E
I
L
K
K
L
N
-
H
P
C
I
I
K
I
K
N
F
F
D
A
E
-
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
-------------------------------
R
L
--------
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
-
V
L
L
S
S
Q
E
E
-
D
C
L
I
K
I
T
D
F
G
H
S
K
I
--
L
G
E---
T
-----
S
----
L
---
M
---
R
-
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V---
G
T
A
--
G
Y
-
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
-
S
E
H
R
T
Q
V
S
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
-
Q
D
E
D
M
K
R
K
F
Q
D
L
L
S
E
E
N
E
S
T
A
L
P
Q
-----------
1
PsiBlast_PDB
72.81
44%
-98
- C1 -
2W4O
1
KCC4_HUMAN
A:
[54-342]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
F
E
V
E
S
E
L
G
R
G
A
T
S
I
V
Y
R
C
K
Q
K
G
T
Q
K
P
Y
A
L
K
V
L
K
K
----------------------------------------
I
G
V
L
L
R
L
S
-
H
P
N
I
I
K
L
K
E
I
F
E
T
P
T
E
I
S
L
V
L
E
L
V
T
G
G
E
L
F
D
R
I
V
E
K
G
-------------------------------
Y
Y
--------
S
E
R
D
A
A
D
A
V
K
Q
I
L
E
A
V
A
Y
L
H
E
N
G
I
V
H
R
D
L
K
P
E
N
-
L
L
Y
A
-
T
P
A
P
D
A
P
L
K
I
A
D
F
-------------------------------------
G
T
P
G
Y
C
A
P
E
I
L
------
R
G
C
--
A
Y
-
G
P
E
V
D
M
W
S
V
G
I
I
T
Y
I
L
L
C
G
F
E
P
F
Y
D
-
E
R
G
D
Q
F
M
F
R
R
I
L
N
C
E
Y
Y
F
I
S
P
W
W
D
E
V
S
L
N
A
K
D
L
V
R
K
L
I
V
L
D
P
K
K
R
L
T
T
F
Q
A
L
Q
H
P
W
V
--
T
G
K
A
A
N
F
V
H
M
D
T
A
Q
K
K
L
Q
E
F
N
A
R
R
K
L
K
A
A
V
K
A
V
V
68
PsiBlast_CBE
72.70
40%
-118
- C1 -
3IGO
8
?
A:
[24-281]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
N
I
V
C
M
L
G
K
G
S
F
G
E
V
L
K
C
K
D
R
I
T
Q
Q
E
Y
A
V
K
V
I
N
K
-----
A
--------
S
A
K
N
------
K
---T
S
----
T
-
I
L
R
E
V
E
L
L
K
K
L
D
-
H
P
N
I
M
K
L
F
E
I
L
E
D
S
S
S
F
Y
I
V
G
E
L
Y
T
G
G
E
L
F
D
E
I
I
K
R
K
-------------------------------
R
F
--------
S
E
H
D
A
A
R
I
I
K
Q
V
F
S
G
I
T
Y
M
H
K
H
N
I
V
H
R
D
L
K
P
E
N
-
I
L
L
E
S
K
E
-
K
D
C
D
I
K
I
I
D
F
G
L
S
T
C
--
F
-----
Q
-----
Q
N
T----------------
T
A
Y
Y
I
A
P
E
V
L
-------
R
G
--
T
Y
-
D
E
K
C
D
V
W
S
A
G
V
I
L
Y
I
L
L
S
G
T
P
P
F
Y
G
--
K
N
E
Y
D
I
L
K
R
V
E
T
G
K
Y
A
F
D
L
P
Q
W
R
T
I
S
D
D
A
K
D
L
I
R
K
M
L
T
F
H
P
S
L
R
I
T
A
T
Q
C
L
E
H
P
W
I
-
Q
K
Y
S
S
E
T
P
T
I
S
D
L
P
S
L
E
S
A
M
T
N
I
R
Q
F
Q
A
E
K
K
L
A
Q
A
24
PsiBlast_CBE
72.46
43%
-121
- C1 -
2JAM
3
KCC1G_HUMAN
B:
[4-266]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
T
N
I
R
K
T
F
I
F
M
E
V
L
G
S
G
A
F
S
E
V
F
L
V
K
Q
R
L
T
G
K
L
F
A
L
K
C
I
K
K
-----
S
----------------------------
S
-
L
E
N
E
I
A
V
L
K
K
I
K
-
H
E
N
I
V
T
L
E
D
I
Y
E
S
T
T
H
Y
Y
L
V
M
Q
L
V
S
G
G
E
L
F
D
R
I
L
E
R
G
-------------------------------
V
Y
--------
T
E
K
D
A
S
L
V
I
Q
Q
V
L
S
A
V
K
Y
L
H
E
N
G
I
V
H
R
D
L
K
P
E
N
-
L
L
Y
L
T
P
E
E
N
S
K
I
M
-
I
T
D
F
G
L
S
K
M
--
E
-----
Q
-----
N
----
G
---
I
---
M
S
T
A
C
G
T
P
G
Y
V
A
P
E
V
L
------
A
Q
K
--
P
Y
-
S
K
A
V
D
C
W
S
I
G
V
I
T
Y
I
L
L
C
G
Y
P
P
F
Y
--
E
E
T
E
S
K
L
F
E
K
I
K
E
G
Y
Y
E
F
E
S
P
F
W
D
D
I
S
E
S
A
K
D
F
I
C
H
L
L
E
K
D
P
N
E
R
Y
T
C
E
K
A
L
S
H
P
W
I
-
D
G
N
T
A
L
H
R
D
I
Y
P
S
V
S
L
Q
I
Q
K
N
F
A
K
-----------
85
PsiBlast_CBE
72.41
38%
-116
- C1 -
4IHP
1
?
A:
[51-313]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
K
-----
R
--------
Q
V
K
Q
------
K
--
T
-
D
K
E
--
S
-
L
L
R
E
V
Q
L
L
K
Q
L
D
-
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
-------------------------------
R
F
--------
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
-
L
L
L
E
-
S
K
S
K
D
A
N
I
R
I
I
D
F
G
L
S
T
H
--
F
E
A
---
S
-----
K
----
K
---
M
---
K
-
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
-------
H
G
--
T
Y
-
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
A
--
N
E
Y
D
I
L
K
K
V
E
K
G
K
Y
T
F
E
L
P
Q
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
A
R
D
A
L
D
H
E
W
I
-
Q
T
Y
T
K
E
Q
I
S
V
P
S
L
D
N
A
I
L
N
I
R
Q
F
Q
G
T
Q
K
L
A
Q
A
A
L
L
75
PsiBlast_CBE
72.40
40%
-116
- C1 -
2WEI
1
?
A:
[24-281]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
N
I
V
C
M
L
G
K
G
S
F
G
E
V
L
K
C
K
D
R
I
T
Q
Q
E
Y
A
V
K
V
I
N
K
-----
A
--------
S
A
K
N
------
K
--
D
T
S
----
T
-
I
L
R
E
V
E
L
L
K
K
L
D
-
H
P
N
I
M
K
L
F
E
I
L
E
D
S
S
S
F
Y
I
V
G
E
L
Y
T
G
G
E
L
F
D
E
I
I
K
R
K
-------------------------------
R
F
--------
S
E
H
D
A
A
R
I
I
K
Q
V
F
S
G
I
T
Y
M
H
K
H
N
I
V
H
R
D
L
K
P
E
N
-
I
L
L
E
S
K
E
-
K
D
C
D
I
K
I
I
D
F
G
L
S
T
C
--
F
-----
Q
-----
Q
NT--
K
---
M
---
K
-
D
R
I
G
T
A
Y
Y
I
A
P
E
V
L
-------
R
G
--
T
Y
-
D
E
K
C
D
V
W
S
A
G
V
I
L
Y
I
L
L
S
G
T
P
P
F
Y
G
--
K
N
E
Y
D
I
L
K
R
V
E
T
G
K
Y
A
F
D
L
P
Q
W
R
T
I
S
D
D
A
K
D
L
I
R
K
M
L
T
F
H
P
S
L
R
I
T
A
T
Q
C
L
E
H
P
W
I
-
Q
K
Y
S
S
E
-----------------------------
96
PsiBlast_CBE
72.28
36%
-125
- C1 -
2YIT
1
CHK2_HUMAN
A:
[3-279]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
Y
-
P
K
A
L
R
D
E
Y
I
M
S
K
T
L
G
S
G
A
C
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
------------------------------L---
N
-
V
E
T
E
I
E
I
L
K
K
L
N
-
H
P
C
I
I
K
I
K
N
F
F
D
A
E
-
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
-------------------------------
R
L
--------
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
-
V
L
L
S
S
Q
E
E
-
D
C
L
I
K
I
T
D
F
G
H
S
K
I
--
L
G
E---
T
-----
S
----
L
---
M
---
R
-
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V---
G
T
A
--
G
Y
-
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
-
S
E
H
R
T
Q
V
S
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
-
Q
D
E
D
M
K
R
K
F
Q
D
L
L
S
E
E
N
E
S
T
A
L
P
Q
-----------
59
PsiBlast_CBE
72.11
41%
-127
- C1 -
3HZT
9
?
A:
[6-263]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
Q
R
V
K
K
L
G
S
G
A
Y
G
E
V
L
L
C
K
D
K
L
T
G
A
E
R
A
I
K
I
I
K
K
-----
S
--------
S
V
T
T
------
T
--
S
-
N
S
G
A
-
L
-
L
D
-
E
V
A
V
L
K
Q
L
D
-
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
R
N
Y
Y
L
V
M
E
V
Y
R
G
G
E
L
F
D
E
I
I
L
R
Q
-------------------------------
K
F
--------
S
E
V
D
A
A
V
I
M
K
Q
V
L
S
G
T
T
Y
L
H
K
H
N
I
V
H
R
D
L
K
P
E
N
-
L
L
L
E
-
S
K
S
R
D
A
L
I
K
I
V
D
F
G
L
S
A
H
FE
V
-----
G
------------------------
T
A
Y
Y
I
A
P
E
V
L
------
R
K
K
---
Y
-
D
E
K
C
D
V
W
S
C
G
V
I
L
Y
I
L
L
C
G
Y
P
P
F
-
G
G
Q
T
D
Q
-
E
I
L
K
R
V
E
K
G
K
F
S
F
D
P
P
D
W
T
Q
V
S
D
E
A
K
Q
L
V
K
L
M
L
T
Y
E
P
S
K
R
I
S
A
E
E
A
L
N
H
P
W
I
-
V
K
F
C
S
Q
V
G
K
H
A
L
T
G
A
L
G
N
M
K
K
F
Q
S
S
Q
K
L
A
Q
A
A
M
L
F
137
HHSearch
71.78
39%
-111
- C1 -
3MWU
1
?
A:
[14-284]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
-----
Y
F
-
Q
G
T
F
A
E
R
Y
N
I
V
C
M
L
G
K
G
S
F
G
E
V
L
K
C
K
D
R
I
T
Q
Q
E
Y
A
V
K
V
I
N
K
-----
A
--------
S
A
K
N
------
K
D-
T
-
S
----
T
-
I
L
R
E
V
E
L
L
K
K
L
D
-
H
P
N
I
M
K
L
F
E
I
L
E
D
S
S
S
F
Y
I
V
G
E
L
Y
T
G
G
E
L
F
D
E
I
I
K
R
K
-------------------------------
R
F
--------
S
E
H
D
A
A
R
I
I
K
Q
V
F
S
G
I
T
Y
M
H
K
H
N
I
V
H
R
D
L
K
P
E
N
-
I
L
L
E
S
K
E
-
K
D
C
D
I
K
I
I
D
F
G
L
S
T
C
--
F
-----
Q
-----
Q
N-------------
D
R
I
G
T
A
Y
Y
I
A
P
E
V
L
------
R
G
---
T
Y
-
D
E
K
C
D
V
W
S
A
G
V
I
L
Y
I
L
L
S
G
T
P
P
F
Y
G
--
K
N
E
Y
D
I
L
K
R
V
E
T
G
K
Y
A
F
D
L
P
Q
W
R
T
I
S
D
D
A
K
D
L
I
R
K
M
L
T
F
H
P
S
L
R
I
T
A
T
Q
C
L
E
H
P
W
I
-
Q
K
Y
S
S
E
T
P
T
I
S
D
L
P
S
L
E
S
A
M
T
N
I
R
Q
F
Q
A
E
K
K
L
A
Q
A
86
PsiBlast_CBE
71.75
38%
-115
- C1 -
4IFG
1
?
A:
[51-313]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
K
-----
R
--------
Q
V
K
Q
------
K
--
T
-
D
K
E
--
S
-
L
L
R
E
V
Q
L
L
K
Q
L
D
-
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
-------------------------------
R
F
--------
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
-
L
L
L
E
-
S
K
S
K
D
A
N
I
R
I
I
D
F
G
L
S
T
H
--
F
EA---
S
-----
K
----
K
---
M
---
K
-
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
-------
H
G
--
T
Y
-
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
A
--
N
E
Y
D
I
L
K
K
V
E
K
G
K
Y
T
F
E
L
P
Q
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
A
R
D
A
L
D
H
E
W
I
-
Q
T
Y
T
K
D
V
P
S
L
D
N
A
I
L
N
I
R
Q
F
Q
G
T
Q
K
L
A
Q
A
A
L
L
Y
M
G
103
PsiBlast_CBE
71.35
36%
-130
- C1 -
4BDK
4
CHK2_HUMAN
A:
[9-285]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
Y
-
P
K
A
L
R
D
E
Y
I
M
S
K
T
L
G
----
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
------------------------------A
L
--
N
-
V
E
T
E
I
E
I
L
K
K
L
N
-
H
P
C
I
I
K
I
K
N
F
F
D
A
E
-
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
-------------------------------
R
L
--------
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
-
V
L
L
S
S
Q
E
E
-
D
C
L
I
K
I
T
D
F
G
H
S
K
I
--
L
G
E---
T
-----
S
----
L
---
M
---
R
-
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V---
G
T
A
--
G
Y
-
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
-
S
E
H
R
T
Q
V
S
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
-
Q
D
E
D
M
K
R
K
F
Q
D
L
L
S
E
E
N
E
S
T
A
L
P
Q
V
L
A
--------
66
PsiBlast_CBE
71.34
40%
-118
- C1 -
3NCG
1
?
A:
[24-281]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
N
I
V
C
M
L
G
K
G
S
F
G
E
V
L
K
C
K
D
R
I
T
Q
Q
E
Y
A
V
K
V
I
N
K
-----
A
--------
S
A
K
N
------
K
--
D
T
S
----
T
-
I
L
R
E
V
E
L
L
K
K
L
D
-
H
P
N
I
M
K
L
F
E
I
L
E
D
S
S
S
F
Y
I
V
G
E
L
Y
T
G
G
E
L
F
D
E
I
I
K
R
K
-------------------------------
R
F
--------
S
E
H
D
A
A
R
I
I
K
Q
V
F
S
G
I
T
Y
M
H
K
H
N
I
V
H
R
D
L
K
P
E
N
-
I
L
L
E
S
K
E
-
K
D
C
D
I
K
I
I
D
F
G
L
S
T
C
--
F
-----
Q
-----
Q
N
T--------------
I
G
T
A
Y
Y
I
A
P
E
V
L
-------
R
G
--
T
Y
-
D
E
K
C
D
V
W
S
A
G
V
I
L
Y
I
L
L
S
G
T
P
P
F
Y
G
--
K
N
E
Y
D
I
L
K
R
V
E
T
G
K
Y
A
F
D
L
P
Q
W
R
T
I
S
D
D
A
K
D
L
I
R
K
M
L
T
F
H
P
S
L
R
I
T
A
T
Q
C
L
E
H
P
W
I
-
Q
K
Y
S
S
E
T
P
T
I
S
D
L
P
S
L
E
S
A
M
T
N
I
R
Q
F
Q
A
E
K
K
L
A
Q
A
95
PsiBlast_CBE
71.27
36%
-127
- C1 -
2YCR
1
CHK2_HUMAN
A:
[3-279]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
Y
-
P
K
A
L
R
D
E
Y
I
M
S
K
T
L
G
S
---
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
----------------------------------
N
-
V
E
T
E
I
E
I
L
K
K
L
N
-
H
P
C
I
I
K
I
K
N
F
F
D
A
E
-
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
-------------------------------
R
L
--------
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
-
V
L
L
S
S
Q
E
E
-
D
C
L
I
K
I
T
D
F
G
H
S
K
I
--
L
G
E---
T
-----
S
----
L
---
M
---
R
-
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V---
G
T
A
--
G
Y
-
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
-
S
E
H
R
T
Q
V
S
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
-
Q
D
E
D
M
K
R
K
F
Q
D
L
L
S
E
E
N
E
S
T
A
K
P
Q
-----------
99
PsiBlast_CBE
71.22
36%
-126
- C1 -
2YCS
1
CHK2_HUMAN
A:
[2-279]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
-----
V
Y
-
P
K
A
L
R
D
E
Y
I
M
S
K
T
L
G
S
---
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
----------------------------------
N
-
V
E
T
E
I
E
I
L
K
K
L
N
-
H
P
C
I
I
K
I
K
N
F
F
D
A
E
-
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
-------------------------------
R
L
--------
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
-
V
L
L
S
S
Q
E
E
-
D
C
L
I
K
I
T
D
F
G
H
S
K
I
--
L
-----
T
-----
S
----
L
---
M
---
R
-
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V---
G
T
A
--
G
Y
-
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
-
S
E
H
R
T
Q
V
S
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
-
Q
D
E
D
M
K
R
K
F
Q
D
L
L
S
E
E
N
E
S
T
A
L
P
Q
-----------
102
PsiBlast_CBE
71.14
36%
-122
- C1 -
2YCF
1
CHK2_HUMAN
A:
[2-279]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
-----
V
Y
-
P
K
A
L
R
D
E
Y
I
M
S
K
T
L
G
S
G
A
C
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
----------------------------------
N
-
V
E
T
E
I
E
I
L
K
K
L
N
-
H
P
C
I
I
K
I
K
N
F
F
D
A
E
-
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
-------------------------------
R
L
--------
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
-
V
L
L
S
S
Q
E
E
-
D
C
L
I
K
I
T
D
F
G
H
S
K
I
--
L
G
E---
T
-----
S
----
L
---
M
---
R
-
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V---
G
T
A
--
G
Y
-
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
-
S
E
H
R
T
Q
V
S
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
-
Q
D
E
D
M
K
R
K
F
Q
D
L
L
S
E
E
N
E
S
T
A
L
P
Q
-----------
97
PsiBlast_CBE
71.00
36%
-126
- C1 -
2YIR
1
CHK2_HUMAN
A:
[2-279]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
-----
V
Y
-
P
K
A
L
R
D
E
Y
I
M
S
K
T
L
G
S
G
A
C
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
------------------------------L---
N
-
V
E
T
E
I
E
I
L
K
K
L
N
-
H
P
C
I
I
K
I
K
N
F
F
D
A
E
-
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
-------------------------------
R
L
--------
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
-
V
L
L
S
S
Q
E
E
-
D
C
L
I
K
I
T
D
F
G
H
S
K
I
--
L
G
E---
T
-----
S
----
L
---
M
---
R
-
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V---
G
T
A
--
G
Y
-
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
-
S
E
H
R
T
Q
V
S
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
-
Q
D
E
D
M
K
R
K
F
Q
D
L
L
S
E
E
N
E
S
T
A
L
P
------------
110
PsiBlast_CBE
70.31
36%
-129
- C1 -
4BDD
4
CHK2_HUMAN
A:
[7-285]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
S
-----
V
Y
-
P
K
A
L
R
D
E
Y
I
M
S
K
T
L
------
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
----------------------------------
N
-
V
E
T
E
I
E
I
L
K
K
L
N
-
H
P
C
I
I
K
I
K
N
F
F
D
A
E
-
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
-------------------------------
R
L
--------
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
-
V
L
L
S
S
Q
E
E
-
D
C
L
I
K
I
T
D
F
G
H
S
K
I
--
L
-----
T
-----
S
----
L
---
M
---
R
-
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V---
G
T
A
--
G
Y
-
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
-
S
E
H
R
T
Q
V
S
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
-
Q
D
E
D
M
K
R
K
F
Q
D
L
L
S
E
E
N
E
S
T
A
L
P
Q
V
L
---------
114
PsiBlast_CBE
70.24
36%
-124
- C1 -
4A9U
10
CHK2_HUMAN
A:
[7-285]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
S
-----
V
Y
-
P
K
A
L
R
D
E
Y
I
M
S
K
T
L
G
S
----
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
------------------------------DP
A
L
N
-
V
E
T
E
I
E
I
L
K
K
L
N
-
H
P
C
I
I
K
I
K
N
F
F
D
A
E
-
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
-------------------------------
R
L
--------
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
-
V
L
L
S
S
Q
E
E
-
D
C
L
I
K
I
T
D
F
G
H
S
K
I
--
L
-----
T
-----
S
----
L
---
M
---
R
-
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V---
G
T
A
--
G
Y
-
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
-
S
E
H
R
T
Q
V
S
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
-
Q
D
E
D
M
K
R
K
F
Q
D
L
L
S
E
E
N
E
S
T
A
L
P
Q
V
L
A
--------
109
PsiBlast_CBE
70.24
36%
-129
- C1 -
4BDE
5
CHK2_HUMAN
A:
[7-285]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
S
-----
V
Y
-
P
K
A
L
R
D
E
Y
I
M
S
K
T
L
------
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
------------------------------A
L
--
N
-
V
E
T
E
I
E
I
L
K
K
L
N
-
H
P
C
I
I
K
I
K
N
F
F
D
A
E
-
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
-------------------------------
R
L
--------
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
-
V
L
L
S
S
Q
E
E
-
D
C
L
I
K
I
T
D
F
G
H
S
K
I
--
L
-----
T
-----
S
----
L
---
M
---
R
-
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V---
G
T
A
--
G
Y
-
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
-
S
E
H
R
T
Q
V
S
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
-
Q
D
E
D
M
K
R
K
F
Q
D
L
L
S
E
E
N
E
S
T
A
L
P
Q
V
L
A
--------
53
PsiBlast_CBE
69.94
41%
-112
- C1 -
4MVF
2
CDPK2_PLAFK
A:
[52-327]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
G
K
L
E
D
K
Y
I
I
D
E
K
L
G
Q
G
T
Y
G
C
V
Y
K
G
I
D
K
V
T
N
Q
L
Y
A
I
K
E
E
K
K
-----
D
--------
R
L
K
N
------
I
--
N
-
R
----
F
-
F
-
Q
E
I
E
I
M
K
K
L
D
-
H
P
N
I
V
K
L
Y
E
T
Y
E
N
D
N
Y
I
Y
L
I
M
E
L
C
S
G
R
E
L
F
D
S
I
I
E
N
G
-------------------------------
S
F
--------
T
E
K
N
A
A
T
I
M
K
Q
I
F
S
A
I
F
Y
L
H
S
L
N
I
V
H
R
D
L
K
P
E
N
-
F
L
F
Q
-
S
E
N
K
D
S
L
L
K
I
I
D
F
G
L
S
K
N
--
L
------------------------------------------------
K
---
Y
-
D
K
K
C
D
I
W
S
S
G
V
I
M
Y
T
L
L
C
G
Y
P
P
F
Y
------------------
C
F
Y
E
N
D
W
G
S
I
S
S
D
A
K
N
L
I
T
K
L
L
T
Y
N
P
N
E
R
C
T
I
E
E
A
L
N
H
P
W
I
------
T
Q
M
T
K
S
--
H
V
E
L
S
S
T
L
L
K
N
L
K
N
F
K
K
E
N
E
L
K
104
PsiBlast_CBE
69.86
36%
-130
- C1 -
4BDJ
1
CHK2_HUMAN
A:
[9-285]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
Y
-
P
K
A
L
R
D
E
Y
I
M
S
K
T
L
G
-----
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
----------------------------------
N
-
V
E
T
E
I
E
I
L
K
K
L
N
-
H
P
C
I
I
K
I
K
N
F
F
D
A
E
-
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
-------------------------------
R
L
--------
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
-
V
L
L
S
S
Q
E
E
-
D
C
L
I
K
I
T
D
F
G
H
S
K
I
--
L
E----
T
-----
S
----
L
---
M
---
R
-
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V---
G
T
A
--
G
Y
-
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
-
S
E
H
R
T
Q
V
S
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
-
Q
D
E
D
M
K
R
K
F
Q
D
L
L
S
E
E
N
E
S
T
A
L
P
Q
V
L
A
--------
98
PsiBlast_CBE
69.80
36%
-125
- C1 -
2YIQ
1
CHK2_HUMAN
A:
[3-279]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
Y
-
P
K
A
L
R
D
E
Y
I
M
S
K
T
L
G
----
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
------------------------------------
V
E
T
E
I
E
I
L
K
K
L
N
-
H
P
C
I
I
K
I
K
N
F
F
D
A
E
-
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
-------------------------------
R
L
--------
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
-
V
L
L
S
S
Q
E
E
-
D
C
L
I
K
I
T
D
F
G
H
S
K
I
--
L
G
E---
T
-----
S
----
L
---
M
---
R
-
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V---
G
T
A
--
G
Y
-
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
-
S
E
H
R
T
Q
V
S
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
-
Q
D
E
D
M
K
R
K
F
Q
D
L
L
S
E
E
N
E
S
T
A
L
P
Q
-----------
101
PsiBlast_CBE
69.55
36%
-125
- C1 -
2W0J
1
CHK2_HUMAN
A:
[2-279]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
-----
V
Y
-
P
K
A
L
R
D
E
Y
I
M
S
K
T
L
G
S
---
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
----------------------------------
N
-
V
E
T
E
I
E
I
L
K
K
L
N
-
H
P
C
I
I
K
I
K
N
F
F
D
A
E
-
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
-------------------------------
R
L
--------
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
-
V
L
L
S
S
Q
E
E
-
D
C
L
I
K
I
T
D
F
G
H
S
K
I
--
L
-----
T
-----
S
----
L
---
M
---
R
-
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V---
G
T
A
--
G
Y
-
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
-
S
E
H
R
T
Q
V
S
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
-
Q
D
E
D
M
K
R
K
F
Q
D
L
L
S
E
E
N
E
T
A
L
P
Q
------------
106
PsiBlast_CBE
68.84
36%
-131
- C1 -
4BDH
4
CHK2_HUMAN
A:
[8-285]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
-----
V
Y
-
P
K
A
L
R
D
E
Y
I
M
S
K
T
L
------
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
----------------------------------
N
-
V
E
T
E
I
E
I
L
K
K
L
N
-
H
P
C
I
I
K
I
K
N
F
F
D
A
E
-
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
-------------------------------
R
L
--------
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
-
V
L
L
S
S
Q
E
E
-
D
C
L
I
K
I
T
D
F
G
H
S
K
I
--
L
G
E---
T
-----
S
----
L
---
M
---
R
-
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V---
G
T
A
--
G
Y
-
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
-
S
E
H
R
T
Q
V
S
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
-
Q
D
E
D
M
K
R
K
F
Q
D
L
L
S
E
E
N
E
S
T
A
L
P
Q
V
L
A
--------
113
PsiBlast_CBE
68.57
36%
-130
- C1 -
4BDA
8
CHK2_HUMAN
A:
[7-285]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
S
-----
V
Y
-
P
K
A
L
R
D
E
Y
I
M
S
K
T
L
G
S
----
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
----------------------------------
N
-
V
E
T
E
I
E
I
L
K
K
L
N
-
H
P
C
I
I
K
I
K
N
F
F
D
A
E
-
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
-------------------------------
R
L
--------
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
-
V
L
L
S
S
Q
E
E
-
D
C
L
I
K
I
T
D
F
G
H
S
K
I
--
L
E----
T
-----
S
----
L
---
M
---
R
-
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V---
G
T
A
--
G
Y
-
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
-
S
E
H
R
T
Q
V
S
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
-
Q
D
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D
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K
R
K
F
Q
D
L
L
S
E
E
N
E
S
T
A
L
P
Q
V
L
---------
146
HHSearch
60.21
33%
-95
- C1 -
2YEX
8
CHK1_HUMAN
A:
[4-268]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
F
V
E
D
W
D
L
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Q
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L
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K
--------
R
A
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------
C
--
P
-
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----
N
-
I
K
K
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G
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L
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R
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P
D
I
-------------------------------
G
M
--------
P
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Y
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-
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L
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----
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N
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F
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L
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--
F
-----
R
YNN
R
E
R
----
L
---
L
---
N
-
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
------
K
R
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--
E
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V
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G
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S
A
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D
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W
Y
-
N
K
P
L
K
------------------------------