@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : DDR1_HUMAN: (2015-10-06 )
MGPEALSSLLLLLLVASGDADMKGHFDPAKCRYALGMQDRTIPDSDISASSSWSDSTAARHSRLESSDGDGAWCPAGSVFPKEEEYLQVDLQRLHLVALVGTQGRHAGGLGKEFSRSYRLRYSRDGRRWMGWKDRWGQEVISGNEDPEGVVLKDLGPPMVARLVRFYPRADRVMSVCLRVELYGCLWRDGLLSYTAPVGQTMYLSEAVYLNDSTYDGHTVGGLQYGGLGQLADGVVGLDDFRKSQELRVWPGYDYVGWSNHSFSSGYVEMEFEFDRLRAFQAMQVHCNNMHTLGARLPGGVECRFRRGPAMAWEGEPMRHNLGGNLGDPRARAVSVPLGGRVARFLQCRFLFAGPWLLFSEISFISDVVNNSSPALGGTFPPAPWWPPGPPPTNFSSLELEPRGQQPVAKAEGSPTAILIGCLVAIILLLLLIIALMLWRLHWRRLLSKAERRVLEEELTVHLSVPGDTILINNRPGPREPPPYQEPRPRGNPPHSAPCVPNGSALLLSNPAYRLLLATYARPPRGPGPPTPAWAKPTNTQAYSGDYMEPEKPGAPLLPPPPQNSVPHYAEADIVTLQGVTGGNTYAVPALPPGAVGDGPPRVDFPRSRLRFKEKLGEGQFGEVHLCEVDSPQDLVSLDFPLNVRKGHPLLVAVKILRPDATKNARNDFLKEVKIMSRLKDPNIIRLLGVCVQDDPLCMITDYMENGDLNQFLSAHQLEDKAAEGAPGDGQAAQGPTISYPMLLHVAAQIASGMRYLATLNFVHRDLATRNCLVGENFTIKIADFGMSRNLYAGDYYRVQGRAVLPIRWMAWECILMGKFTTASDVWAFGVTLWEVLMLCRAQPFGQLTDEQVIENAGEFFRDQGRQVYLSRPPACPQGLYELMLRCWSRESEQRPPFSQLHRFLAEDALNTV
Atome Classification :
(106 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600....---.....610..-.....620.......630--........640.......-650.......660.......670.......-680........690..-.....700.......710.......720........730.....-..740.......750.......760.......770...-----....780.......790...-....800.......810.......820.......830.......840.......850........860.......870.......880.......890.......900........910.
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
G
P
E
A
L
S
S
L
L
L
L
L
L
VASGDADMKGHF
D
P
A
K
C
R
Y
ALGMQDRTIPDSDISASSSWSD
S
T
A
A
R
H
SRLESSDGDGAWCPAGSVFPK
E
E
E
Y
L
Q
V
D
L
Q
R
L
H
L
V
A
L
VGTQGRHAGGL
G
K
E
F
S
R
S
Y
R
L
R
YSRDGRRWMGW
K
D
R
W
G
Q
E
V
ISGNEDPE
G
V
V
L
KDLG
P
P
M
V
A
R
L
V
R
FYPR
A
D
R
V
M
S
V
C
L
R
V
E
L
Y
G
C
L
W
RDG
L
L
S
YTAPVG
Q
T
M
Y
L
S
E
A
V
Y
LNDSTYDG
H
T
VG
G
L
QYG
G
L
G
Q
L
A
D
GVV
G
L
D
D
FRKSQE
L
R
VWPGYDYVGWSNHSFSSG
Y
V
E
M
E
F
E
F
D
R
L
R
A
F
Q
A
M
Q
V
HCNN
M
H
T
L
GARLPGG
V
E
C
R
F
RRGPAMAWEGEP
M
R
H
NLGGNLGDPR
A
R
A
V
SVPL
G
G
R
V
A
R
F
L
Q
C
R
F
LFA
G
P
W
L
L
F
S
E
I
S
F
I
S
D
V
VNNSSPALGGTFPPAPWWPPGPPPTNFSS
L
E
LEPRGQQPVAKAEGSP
T
A
I
L
I
G
C
L
V
A
I
I
L
L
L
L
L
I
I
A
L
M
L
W
R
L
H
W
R
R
L
L
S
K
A
E
R
R
V
L
E
E
E
L
T
V
H
L
SVPG
D
T
I
L
INNRPGPREPPPYQEPRPRGNPPHSAPCVPNG
S
A
L
L
LSNPA
Y
R
L
L
L
A
T
YARPPRGPGPPTPAWAKPTNTQAYSGDYMEPEKPGAPLLPPPPQNSVPHYAEA
D
I
V
T
L
Q
GVTGG
N
T
Y
AVPALPPGAVGDGP--PRVD---F
P
R
S
R
L
R
F
K
E
-
K
LGEGQFG
E
V
H
L
C
EVDS---PQ
D
L
V
SLDFPLNVRKG
H
P
-
L
L
V
A
V
K
I
LRPDAT
K
N
A
R
N
D
F
L
K
E
V
K
I
M
S
RL-KD-P
N
I
I
R
L
L
G
V
CVQD-D
P
L
C
M
I
T
D
Y
MENG
D
L
N
Q
F
L
S
A
H
Q
L
E
D
K
-AAEGAPGDGQAAQGPT-I
S
Y
P
M
L
L
H
V
A
A
Q
I
AS
G
M
R
Y
L
A
T
L
N
F
V
H
R
D
LATRNCLVG-----E
N
F
T
I
K
I
ADFGMSRNLYAG
D
-
Y
Y
R
VQG
R
A
V
L
P
I
R
W
M
A
W
E
C
I
L
MGKFTT
A
S
D
V
W
A
F
G
V
T
L
W
E
V
L
M
L
CRAQPFGQL
T
D
-
E
Q
V
I
E
N
A
G
E
F
F
R
DQG
R
Q
V
Y
LSRPPA
C
P
Q
G
L
Y
E
L
M
L
R
CWSRESEQRP
P
F
S
Q
-
L
H
R
F
L
A
E
D
ALNTV
115
HHSearch
96.29
100%
-142
- C1 -
4BKJ
10
DDR1_HUMAN
A:
[3-315]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
R
V
D
---
F
P
R
S
R
L
R
F
K
E
-
K
L
G
E
G
Q
F
G
E
V
H
L
C
E
V
D
S
---
P
Q
D
L
V
S
L
D
F
P
L
N
V
R
K
G
H
P
-
L
L
V
A
V
K
I
L
R
P
D
A
T
K
N
A
R
N
D
F
L
K
E
V
K
I
M
S
R
L
-
K
D
-
P
N
I
I
R
L
L
G
V
C
V
Q
D
-
D
P
L
C
M
I
T
D
Y
M
E
N
G
D
L
N
Q
F
L
S
A
H
Q
L
E
D
----------------
P
T
-
I
S
Y
P
M
L
L
H
V
A
A
Q
I
A
S
G
M
R
Y
L
A
T
L
N
F
V
H
R
D
L
A
T
R
N
C
L
V
G
-----
E
N
F
T
I
K
I
A
D
F
G
M
S
R
N
L
Y
A
G
D
-
Y
Y
----
R
A
V
L
P
I
R
W
M
A
W
E
C
I
L
M
G
K
F
T
T
A
S
D
V
W
A
F
G
V
T
L
W
E
V
L
M
L
C
R
A
Q
P
F
G
Q
L
T
D
-
E
Q
V
I
E
N
A
G
E
F
F
R
D
Q
G
R
Q
V
Y
L
S
R
P
P
A
C
P
Q
G
L
Y
E
L
M
L
R
C
W
S
R
E
S
E
Q
R
P
P
F
S
Q
-
L
H
R
F
L
A
E
D
A
L
N
T
V
6
PsiBlast_PDB
96.29
100%
-142
- C1 -
4BKJ
10
DDR1_HUMAN
A:
[3-315]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
R
V
D
---
F
P
R
S
R
L
R
F
K
E
-
K
L
G
E
G
Q
F
G
E
V
H
L
C
E
V
D
S
---
P
Q
D
L
V
S
L
D
F
P
L
N
V
R
K
G
H
P
-
L
L
V
A
V
K
I
L
R
P
D
A
T
K
N
A
R
N
D
F
L
K
E
V
K
I
M
S
R
L
-
K
D
-
P
N
I
I
R
L
L
G
V
C
V
Q
D
-
D
P
L
C
M
I
T
D
Y
M
E
N
G
D
L
N
Q
F
L
S
A
H
Q
L
E
D
----------------
P
T
-
I
S
Y
P
M
L
L
H
V
A
A
Q
I
A
S
G
M
R
Y
L
A
T
L
N
F
V
H
R
D
L
A
T
R
N
C
L
V
G
-----
E
N
F
T
I
K
I
A
D
F
G
M
S
R
N
L
Y
A
G
D
-
Y
Y
----
R
A
V
L
P
I
R
W
M
A
W
E
C
I
L
M
G
K
F
T
T
A
S
D
V
W
A
F
G
V
T
L
W
E
V
L
M
L
C
R
A
Q
P
F
G
Q
L
T
D
-
E
Q
V
I
E
N
A
G
E
F
F
R
D
Q
G
R
Q
V
Y
L
S
R
P
P
A
C
P
Q
G
L
Y
E
L
M
L
R
C
W
S
R
E
S
E
Q
R
P
P
F
S
Q
-
L
H
R
F
L
A
E
D
A
L
N
T
V
21
PsiBlast_CBE
94.68
100%
-142
- C1 -
4BKJ
11
B:
[3-315]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
R
V
D
---
F
P
R
S
R
L
R
F
K
E
-
K
L
G
E
G
Q
F
G
E
V
H
L
C
E
V
D
S
---
P
Q
D
L
V
S
L
D
F
P
L
N
V
R
K
G
H
P
-
L
L
V
A
V
K
I
L
R
P
D
A
T
K
N
A
R
N
D
F
L
K
E
V
K
I
M
S
R
L
-
K
D
-
P
N
I
I
R
L
L
G
V
C
V
Q
D
-
D
P
L
C
M
I
T
D
Y
M
E
N
G
D
L
N
Q
F
L
S
A
H
Q
L
E
D
K
--------------
G
P
T
-
I
S
Y
P
M
L
L
H
V
A
A
Q
I
A
S
G
M
R
Y
L
A
T
L
N
F
V
H
R
D
L
A
T
R
N
C
L
V
G
-----
E
N
F
T
I
K
I
A
D
F
G
M
S
R
N
L
Y
A
G
D
-
Y
Y
----
R
A
V
L
P
I
R
W
M
A
W
E
C
I
L
M
G
K
F
T
T
A
S
D
V
W
A
F
G
V
T
L
W
E
V
L
M
L
C
R
A
Q
P
F
G
Q
L
T
D
-
E
Q
V
I
E
N
A
G
E
F
F
R
D
Q
G
R
Q
V
Y
L
S
R
P
P
A
C
P
Q
G
L
Y
E
L
M
L
R
C
W
S
R
E
S
E
Q
R
P
P
F
S
Q
-
L
H
R
F
L
A
E
D
A
L
N
T
V
5
PsiBlast_PDB
94.55
100%
-139
- C1 -
3ZOS
4
DDR1_HUMAN
A:
[4-315]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
V
D
---
F
P
R
S
R
L
R
F
K
E
-
K
L
G
E
G
Q
F
G
E
V
H
L
C
E
V
D
S
---
P
Q
D
L
V
S
L
D
F
P
L
N
V
R
K
G
H
P
-
L
L
V
A
V
K
I
L
R
P
D
A
T
K
N
A
R
N
D
F
L
K
E
V
K
I
M
S
R
L
-
K
D
-
P
N
I
I
R
L
L
G
V
C
V
Q
D
-
D
P
L
C
M
I
T
D
Y
M
E
N
G
D
L
N
Q
F
L
S
A
H
Q
L
E
D
------------
A
A
Q
G
P
T
-
I
S
Y
P
M
L
L
H
V
A
A
Q
I
A
S
G
M
R
Y
L
A
T
L
N
F
V
H
R
D
L
A
T
R
N
C
L
V
G
-----
E
N
F
T
I
K
I
A
D
F
G
M
S
R
N
L
Y
A
G
D
-
Y
Y
R
V
Q
G
R
A
V
L
P
I
R
W
M
A
W
E
C
I
L
M
G
K
F
T
T
A
S
D
V
W
A
F
G
V
T
L
W
E
V
L
M
L
C
R
A
Q
P
F
G
Q
L
T
D
-
E
Q
V
I
E
N
A
G
E
F
F
R
D
Q
G
R
Q
V
Y
L
S
R
P
P
A
C
P
Q
G
L
Y
E
L
M
L
R
C
W
S
R
E
S
E
Q
R
P
P
F
S
Q
-
L
H
R
F
L
A
E
D
A
L
N
T
V
22
PsiBlast_CBE
94.48
100%
-136
- C1 -
3ZOS
3
B:
[3-315]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
R
V
D
---
F
P
R
S
R
L
R
F
K
E
-
K
L
G
E
G
Q
F
G
E
V
H
L
C
E
V
D
S
---
P
Q
D
L
V
S
L
D
F
P
L
N
V
R
K
G
H
P
-
L
L
V
A
V
K
I
L
R
P
D
A
T
K
N
A
R
N
D
F
L
K
E
V
K
I
M
S
R
L
-
K
D
-
P
N
I
I
R
L
L
G
V
C
V
Q
D
-
D
P
L
C
M
I
T
D
Y
M
E
N
G
D
L
N
Q
F
L
S
A
H
Q
L
E
D
K
-------------
Q
G
P
T
-
I
S
Y
P
M
L
L
H
V
A
A
Q
I
A
S
G
M
R
Y
L
A
T
L
N
F
V
H
R
D
L
A
T
R
N
C
L
V
G
-----
E
N
F
T
I
K
I
A
D
F
G
M
S
R
N
L
Y
A
G
D
-
Y
Y
R
V
Q
G
R
A
V
L
P
I
R
W
M
A
W
E
C
I
L
M
G
K
F
T
T
A
S
D
V
W
A
F
G
V
T
L
W
E
V
L
M
L
C
R
A
Q
P
F
G
Q
L
T
D
-
E
Q
V
I
E
N
A
G
E
F
F
R
D
Q
G
R
Q
V
Y
L
S
R
P
P
A
C
P
Q
G
L
Y
E
L
M
L
R
C
W
S
R
E
S
E
Q
R
P
P
F
S
Q
-
L
H
R
F
L
A
E
D
A
L
N
T
V
3
PsiBlast_PDB
93.70
100%
-148
- C1 -
5BVW
1
?
A:
[15-322]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
---
F
P
R
S
R
L
R
F
K
E
-
K
L
G
E
G
Q
F
G
E
V
H
L
C
E
V
D
S
-------------------
H
P
-
L
L
V
A
V
K
I
L
R
P
D
A
T
K
N
A
R
N
D
F
L
K
E
V
K
I
M
S
R
L
-
K
D
-
P
N
I
I
R
L
L
G
V
C
V
Q
D
-
D
P
L
C
M
I
T
D
Y
M
E
N
G
D
L
N
Q
F
L
S
A
H
Q
L
E
D
K
---------------
P
T
-
I
S
Y
P
M
L
L
H
V
A
A
Q
I
A
S
G
M
R
Y
L
A
T
L
N
F
V
H
R
D
L
A
T
R
N
C
L
V
G
-----
E
N
F
T
I
K
I
A
D
F
G
----
L
Y
A
G
D
-
Y
Y
R
V
Q
G
R
A
V
L
P
I
R
W
M
A
W
E
C
I
L
M
G
K
F
T
T
A
S
D
V
W
A
F
G
V
T
L
W
E
V
L
M
L
C
R
A
Q
P
F
G
Q
L
T
D
-
E
Q
V
I
E
N
A
G
E
F
F
R
D
Q
G
R
Q
V
Y
L
S
R
P
P
A
C
P
Q
G
L
Y
E
L
M
L
R
C
W
S
R
E
S
E
Q
R
P
P
F
S
Q
-
L
H
R
F
L
A
E
D
A
L
N
--
2
PsiBlast_PDB
92.58
100%
-142
- C1 -
5BVK
1
?
A:
[15-322]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
---
F
P
R
S
R
L
R
F
K
E
-
K
L
G
E
G
Q
F
G
E
V
H
L
C
E
V
D
S
-------------------
H
P
-
L
L
V
A
V
K
I
L
R
P
D
A
T
K
N
A
R
N
D
F
L
K
E
V
K
I
M
S
R
L
-
K
D
-
P
N
I
I
R
L
L
G
V
C
V
Q
D
-
D
P
L
C
M
I
T
D
Y
M
E
N
G
D
L
N
Q
F
L
S
A
H
Q
L
E
D
K
---------------
P
T
-
I
S
Y
P
M
L
L
H
V
A
A
Q
I
A
S
G
M
R
Y
L
A
T
L
N
F
V
H
R
D
L
A
T
R
N
C
L
V
G
-----
E
N
F
T
I
K
I
A
D
F
G
M
S
R
N
L
Y
A
G
D
-
Y
Y
R
V
Q
G
R
A
V
L
P
I
R
W
M
A
W
E
C
I
L
M
G
K
F
T
T
A
S
D
V
W
A
F
G
V
T
L
W
E
V
L
M
L
C
R
A
Q
P
F
G
Q
L
T
D
-
E
Q
V
I
E
N
A
G
E
F
F
R
D
Q
G
R
Q
V
Y
L
S
R
P
P
A
C
P
Q
G
L
Y
E
L
M
L
R
C
W
S
R
E
S
E
Q
R
P
P
F
S
Q
-
L
H
R
F
L
A
E
D
A
L
N
--
4
PsiBlast_PDB
90.98
100%
-145
- C1 -
5BVN
1
?
A:
[15-322]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
---
F
P
R
S
R
L
R
F
K
E
-
K
L
G
E
G
Q
F
G
E
V
H
L
C
E
V
D
S
-------------------
H
P
-
L
L
V
A
V
K
I
L
R
P
D
A
T
K
N
A
R
N
D
F
L
K
E
V
K
I
M
S
R
L
-
K
D
-
P
N
I
I
R
L
L
G
V
C
V
Q
D
-
D
P
L
C
M
I
T
D
Y
M
E
N
G
D
L
N
Q
F
L
S
A
H
Q
L
E
D
K
---------------
P
T
-
I
S
Y
P
M
L
L
H
V
A
A
Q
I
A
S
G
M
R
Y
L
A
T
L
N
F
V
H
R
D
L
A
T
R
N
C
L
V
G
-----
E
N
F
T
I
K
I
A
D
F
G
M
S
R
N
L
Y
A
G
D
-
Y
Y
R
V
Q
G
R
A
V
L
P
I
R
W
M
A
W
E
C
I
L
M
G
K
F
T
T
A
S
D
V
W
A
F
G
V
T
L
W
E
V
L
M
L
C
R
A
Q
P
F
G
Q
L
T
D
-
E
Q
V
I
E
N
A
G
E
F
F
R
D
Q
G
R
Q
V
Y
L
S
R
P
P
A
C
P
Q
G
L
Y
E
L
M
L
R
C
W
S
R
E
S
E
Q
R
P
P
F
S
Q
-
L
H
R
F
L
A
E
D
A
L
N
--
8
PsiBlast_PDB
74.57
47%
-135
- C1 -
4AT4
1
A:
[10-284]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
K
R
H
N
I
V
L
K
R
-
E
L
G
E
G
A
F
G
K
V
F
L
A
E
C
Y
N
LC------------------
K
-
I
L
V
A
V
K
T
L
K
-
D
A
S
D
N
A
R
K
D
F
H
R
E
A
E
L
L
T
N
L
-
Q
H
-
E
H
I
V
K
F
Y
G
V
C
V
E
G
-
D
P
L
I
M
V
F
E
Y
M
K
H
G
D
L
N
K
F
L
R
A
H
G
P
D
A
V
L
M
A
---
P
--------
P
T
E
L
T
Q
S
Q
M
L
H
I
A
Q
Q
I
A
A
G
M
V
Y
L
A
S
Q
H
F
V
H
R
D
L
A
T
R
N
C
L
V
G
-----
E
N
L
L
V
K
I
G
D
F
G
M
S
R
D
V
Y
S
T
D
-
Y
Y
R
V
G
G
H
T
M
L
P
I
R
W
M
P
P
E
S
I
M
Y
R
K
F
T
T
E
S
D
V
W
S
L
G
V
V
L
W
E
I
F
T
Y
G
K
-
Q
P
W
Y
Q
L
S
N
-
N
E
V
I
E
C
I
-----
T
Q
G
R
--
V
L
Q
R
P
R
T
C
P
Q
E
V
Y
E
L
M
L
G
C
W
Q
R
E
P
H
M
R
K
N
I
K
G
-
I
H
T
L
L
Q
N
L
A
K
A
S
P
9
PsiBlast_PDB
74.02
47%
-129
- C1 -
4AT5
2
A:
[10-284]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
K
R
H
N
I
V
L
K
R
-
E
L
G
E
G
A
F
G
K
V
F
L
A
E
C
Y
N
L-------------------
K
-
I
L
V
A
V
K
T
L
K
-
D
A
S
D
N
A
R
K
D
F
H
R
E
A
E
L
L
T
N
L
-
Q
H
-
E
H
I
V
K
F
Y
G
V
C
V
E
G
-
D
P
L
I
M
V
F
E
Y
M
K
H
G
D
L
N
K
F
L
R
A
H
G
P
D
A
V
L
M
A
E
G
N
P
--------
P
T
E
L
T
Q
S
Q
M
L
H
I
A
Q
Q
I
A
A
G
M
V
Y
L
A
S
Q
H
F
V
H
R
D
L
A
T
R
N
C
L
V
G
-----
E
N
L
L
V
K
I
G
D
F
G
M
S
R
D
V
Y
S
T
D
-
Y
Y
R
V
G
G
H
T
M
L
P
I
R
W
M
P
P
E
S
I
M
Y
R
K
F
T
T
E
S
D
V
W
S
L
G
V
V
L
W
E
I
F
T
Y
G
K
-
Q
P
W
Y
Q
L
S
N
-
N
E
V
I
E
C
I
-----
T
Q
G
R
--
V
L
Q
R
P
R
T
C
P
Q
E
V
Y
E
L
M
L
G
C
W
Q
R
E
P
H
M
R
K
N
I
K
G
-
I
H
T
L
L
Q
N
L
A
K
A
S
P
7
PsiBlast_PDB
73.70
47%
-132
- C1 -
4AT3
1
A:
[10-284]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
K
R
H
N
I
V
L
K
R
-
E
L
G
E
G
A
F
G
K
V
F
L
A
E
C
Y
N
LC------------------
K
-
I
L
V
A
V
K
T
L
---
A
S
D
N
A
R
K
D
F
H
R
E
A
E
L
L
T
N
L
-
Q
H
-
E
H
I
V
K
F
Y
G
V
C
V
E
G
-
D
P
L
I
M
V
F
E
Y
M
K
H
G
D
L
N
K
F
L
R
A
H
G
P
D
A
V
L
M
A
--
N
P
--------
P
T
E
L
T
Q
S
Q
M
L
H
I
A
Q
Q
I
A
A
G
M
V
Y
L
A
S
Q
H
F
V
H
R
D
L
A
T
R
N
C
L
V
G
-----
E
N
L
L
V
K
I
G
D
F
G
M
S
R
--
Y
S
T
D
-
Y
Y
R
V
G
G
H
T
M
L
P
I
R
W
M
P
P
E
S
I
M
Y
R
K
F
T
T
E
S
D
V
W
S
L
G
V
V
L
W
E
I
F
T
Y
G
K
-
Q
P
W
Y
Q
L
S
N
-
N
E
V
I
E
C
I
-----
T
Q
G
R
--
V
L
Q
R
P
R
T
C
P
Q
E
V
Y
E
L
M
L
G
C
W
Q
R
E
P
H
M
R
K
N
I
K
G
-
I
H
T
L
L
Q
N
L
A
K
A
S
P
11
PsiBlast_PDB
72.90
45%
-143
- C1 -
3V5Q
1
NTRK3_HUMAN
A:
[6-289]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
I
--
H
V
Q
H
---
I
K
R
R
D
I
V
L
K
R
-
E
L
------
K
V
F
L
A
E
C
-------------
Y
N
L
S
P
T
K
D
-
K
-
M
L
V
A
V
K
A
L
---
P
T
L
A
A
R
K
D
F
Q
R
E
A
E
L
L
T
N
L
-
Q
H
-
E
H
I
V
K
F
Y
G
V
C
G
D
G
-
D
P
L
I
M
V
F
E
Y
M
K
H
G
D
L
N
K
F
L
R
A
H
G
P
------------------
E
--
L
G
L
S
Q
M
L
H
I
A
S
Q
I
A
S
G
M
V
Y
L
A
S
Q
H
F
V
H
R
D
L
A
T
R
N
C
L
V
G
-----
A
N
L
L
V
K
I
G
D
F
G
M
--
D
V
Y
S
T
D
-
Y
Y
R
----
T
M
L
P
I
R
W
M
P
P
E
S
I
M
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
I
L
W
E
I
F
T
Y
G
K
-
Q
P
W
F
Q
L
S
N
-
T
E
V
I
E
C
I
-----
T
Q
G
R
--
V
L
E
R
P
R
V
C
P
K
E
V
Y
D
V
M
L
G
C
W
Q
R
E
P
Q
Q
R
L
N
I
K
E
-
I
Y
K
I
L
H
A
L
G
K
A
T
P
119
HHSearch
72.89
47%
-137
* C1 *
4AOJ
1
NTRK1_HUMAN
A:
[34-316]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
C
V
H
H
---
I
K
R
R
D
I
V
L
K
W
-
E
L
G
E
G
A
F
G
K
V
F
L
A
E
C
H
N
---
L
-----------
L
P
---
K
-
M
L
V
A
V
K
A
L
K
E
-
A
S
E
S
A
R
Q
D
F
Q
R
E
A
E
L
L
T
M
L
-
Q
H
-
Q
H
I
V
R
F
F
G
V
C
T
E
G
-
R
P
L
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
R
S
H
G
P
D
----------------
P
G
P
-
L
G
L
G
Q
L
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
G
-----
Q
G
L
V
V
K
I
G
D
F
G
-----------------
T
M
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
-
Y
G
K
Q
P
W
Y
Q
L
S
N
-
T
E
A
I
D
C
I
T
-----
Q
G
R
--
E
L
E
R
P
R
A
C
P
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
-
V
H
A
R
L
Q
A
L
A
Q
A
P
P
24
PsiBlast_CBE
72.78
45%
-135
- C1 -
4AOJ
1
NTRK1_HUMAN
B:
[38-311]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
K
R
R
D
I
V
L
K
W
-
E
L
G
E
G
A
F
G
K
V
F
L
A
E
C
H
N
LLP-----------------
K
-
M
L
V
A
V
K
A
L
K
-
E
A
S
E
S
A
R
Q
D
F
Q
R
E
A
E
L
L
T
M
L
-
Q
H
-
Q
H
I
V
R
F
F
G
V
C
T
E
G
-
R
P
L
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
R
S
H
G
P
D
----------------
G
P
--
L
G
L
G
Q
L
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
G
-----
Q
G
L
V
V
K
I
G
D
F
--------------------
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
Y
G
K
-
Q
P
W
Y
Q
L
S
N
-
T
E
A
I
D
C
I
-----
T
Q
G
R
E
--
L
E
R
P
R
A
C
P
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
-
V
H
A
R
L
Q
A
L
A
Q
A
P
P
23
PsiBlast_CBE
72.03
45%
-135
- C1 -
4AOJ
1
C:
[38-311]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
K
R
R
D
I
V
L
K
W
-
E
L
G
E
G
A
F
G
K
V
F
L
A
E
C
H
N
LLP-
Q
D
--------------
K
-
M
L
V
A
V
K
A
L
K
-
E
A
S
E
S
A
R
Q
D
F
Q
R
E
A
E
L
L
T
M
L
-
Q
H
-
Q
H
I
V
R
F
F
G
V
C
T
E
G
-
R
P
L
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
R
S
H
G
P
D
----------------
G
P
--
L
G
L
G
Q
L
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
G
-----
Q
G
L
V
V
K
I
G
D
F
G
M
-----------------
M
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
Y
G
K
-
Q
P
W
Y
Q
L
S
N
-
T
E
A
I
D
C
I
-----
T
Q
G
R
E
--
L
E
R
P
R
A
C
P
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
-
V
H
A
R
L
Q
A
L
A
Q
A
P
P
97
PsiBlast_CBE
71.71
37%
-125
- C1 -
1I44
1
A:
[9-289]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
--
D
E
W
E
---
V
S
R
E
K
I
T
L
L
R
-
E
L
G
Q
G
S
F
G
M
V
Y
---
E
G
N
---
A
R
D
I
I
---------
K
G
E
A
E
T
R
V
A
V
K
T
V
N
E
S
A
S
L
R
E
R
I
E
F
L
N
E
A
S
V
M
K
G
F
-
T
C
-
H
H
V
V
R
L
L
G
V
V
S
K
G
-
Q
P
T
L
V
V
M
E
L
M
A
H
G
D
L
K
S
Y
L
R
S
L
R
P
E
----
A
E
N
N
P
G
R
------
P
P
-
P
T
L
Q
E
M
I
Q
M
A
A
E
I
A
D
G
M
A
Y
L
N
A
K
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
-----
H
D
F
T
V
K
I
G
D
F
G
M
T
-----------------
L
P
V
R
W
M
A
P
E
S
L
K
D
G
V
F
T
T
S
S
D
M
W
S
F
G
V
V
L
W
E
I
T
S
L
A
E
-
Q
P
Y
Q
G
L
S
N
-
E
Q
V
L
----
K
F
V
M
D
G
G
---
Y
L
D
Q
P
D
N
C
P
E
R
V
T
D
L
M
R
M
C
W
Q
F
N
P
K
M
R
P
T
F
L
E
-
I
V
N
L
L
K
D
D
L
H
P
S
F
58
PsiBlast_CBE
71.11
37%
-119
- C1 -
4IBM
1
?
A:
[9-289]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
--
D
E
W
E
---
V
S
R
E
K
I
T
L
L
R
-
E
L
G
Q
G
S
F
G
M
V
Y
---
E
G
N
---
A
R
D
I
I
---------
K
G
E
A
E
T
R
V
A
V
K
T
V
N
E
S
A
S
L
R
E
R
I
E
F
L
N
E
A
S
V
M
K
G
F
-
T
C
-
H
H
V
V
R
L
L
G
V
V
S
K
G
-
Q
P
T
L
V
V
M
E
L
M
A
H
G
D
L
K
S
Y
L
R
S
L
R
P
E
----
A
E
N
N
P
G
R
------
P
P
-
P
T
L
Q
E
M
I
Q
M
A
A
E
I
A
D
G
M
A
Y
L
N
A
K
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
-----
H
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
T
D
-
Y
Y
R
K
G
G
K
G
L
L
P
V
R
W
M
A
P
E
S
L
K
D
G
V
F
T
T
S
S
D
M
W
S
F
G
V
V
L
W
E
I
T
S
L
A
E
-
Q
P
Y
Q
G
L
S
N
-
E
Q
V
L
----
K
F
V
M
D
G
G
---
Y
L
D
Q
P
D
N
C
P
E
R
V
T
D
L
M
R
M
C
W
Q
F
N
P
N
M
R
P
T
F
L
E
-
I
V
N
L
L
K
D
D
L
H
P
S
F
86
PsiBlast_CBE
70.93
37%
-133
- C1 -
3EKK
1
A:
[10-290]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
--
D
E
W
E
---
V
S
R
E
K
I
T
L
L
R
-
E
L
G
Q
G
S
F
G
M
V
Y
---
E
G
N
---
A
R
D
I
I
---------
K
G
E
A
E
T
R
V
A
V
K
T
V
N
E
S
A
S
L
R
E
R
I
E
F
L
N
E
A
S
V
M
K
G
F
-
T
C
-
H
H
V
V
R
L
L
G
V
V
S
K
G
-
Q
P
T
L
V
V
M
E
L
M
A
H
G
D
L
K
S
Y
L
R
S
L
R
P
E
----
A
E
N
N
P
G
R
------
P
P
-
P
T
L
Q
E
M
I
Q
M
A
A
E
I
A
D
G
M
A
Y
L
N
A
K
K
F
V
H
R
N
L
A
A
R
N
C
M
V
A
-----
H
D
F
T
V
K
I
G
D
F
-------------------
L
L
P
V
R
W
M
A
P
E
S
L
K
D
G
V
F
T
T
S
S
D
M
W
S
F
G
V
V
L
W
E
I
T
S
L
A
E
-
Q
P
Y
Q
G
L
S
N
-
E
Q
V
L
----
K
F
V
M
D
G
G
---
Y
L
D
Q
P
D
N
C
P
E
R
V
T
D
L
M
R
M
C
W
Q
F
N
P
N
M
R
P
T
F
L
E
-
I
V
N
L
L
K
D
D
L
H
P
S
F
14
PsiBlast_PDB
70.69
45%
-135
- C1 -
4AOJ
1
NTRK1_HUMAN
A:
[38-311]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
K
R
R
D
I
V
L
K
W
-
E
L
G
E
G
A
F
G
K
V
F
L
A
E
C
H
N
LLP-----------------
K
-
M
L
V
A
V
K
A
L
K
-
E
A
S
E
S
A
R
Q
D
F
Q
R
E
A
E
L
L
T
M
L
-
Q
H
-
Q
H
I
V
R
F
F
G
V
C
T
E
G
-
R
P
L
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
R
S
H
G
P
D
---------------
P
G
P
--
L
G
L
G
Q
L
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
G
-----
Q
G
L
V
V
K
I
G
D
F
G
-----------------
T
M
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
Y
G
K
-
Q
P
W
Y
Q
L
S
N
-
T
E
A
I
D
C
I
-----
T
Q
G
R
E
--
L
E
R
P
R
A
C
P
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
-
V
H
A
R
L
Q
A
L
A
Q
A
P
P
12
PsiBlast_PDB
70.40
44%
-113
- C1 -
4YNE
2
A:
[4-285]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
S
G
I
--
R
V
H
H
---
I
K
R
R
D
I
V
L
K
W
-
E
L
G
E
G
A
F
G
K
V
F
L
A
E
C
H
N
LLP--
D
--------------
K
-
M
L
V
A
V
K
A
L
K
-
E
-----
R
Q
D
F
Q
R
E
A
E
L
L
T
M
L
-
Q
H
-
Q
H
I
V
R
F
F
G
V
C
T
E
G
-
R
P
L
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
R
S
H
G
P
D
A
K
-
L
L
A
G
G
E
---
D
V
A
P
G
P
--
L
G
L
G
Q
L
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
G
-----
Q
G
L
V
V
K
I
G
D
F
G
M
S
-----
T
D
-
Y
Y
----
R
T
M
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
Y
G
K
-
Q
P
W
Y
Q
L
S
N
-
T
E
A
I
D
C
I
-----
T
Q
G
R
E
--
L
E
R
P
R
A
C
P
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
-
V
H
A
R
L
Q
A
L
A
Q
A
P
P
85
PsiBlast_CBE
70.27
37%
-124
- C1 -
3EKN
1
A:
[10-290]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
--
D
E
W
E
---
V
S
R
E
K
I
T
L
L
R
-
E
L
G
Q
G
S
F
G
M
V
Y
---
E
G
N
---
A
R
D
I
I
---------
K
G
E
A
E
T
R
V
A
V
K
T
V
N
E
S
A
S
L
R
E
R
I
E
F
L
N
E
A
S
V
M
K
G
F
-
T
C
-
H
H
V
V
R
L
L
G
V
V
S
K
G
-
Q
P
T
L
V
V
M
E
L
M
A
H
G
D
L
K
S
Y
L
R
S
L
R
P
E
----
A
E
N
N
P
G
R
------
P
P
-
P
T
L
Q
E
M
I
Q
M
A
A
E
I
A
D
G
M
A
Y
L
N
A
K
K
F
V
H
R
N
L
A
A
R
N
C
M
V
A
-----
H
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
T
D
-
Y
Y
R
K
G
---
L
L
P
V
R
W
M
A
P
E
S
L
K
D
G
V
F
T
T
S
S
D
M
W
S
F
G
V
V
L
W
E
I
T
S
L
A
E
-
Q
P
Y
Q
G
L
S
N
-
E
Q
V
L
----
K
F
V
M
D
G
G
---
Y
L
D
Q
P
D
N
C
P
E
R
V
T
D
L
M
R
M
C
W
Q
F
N
P
N
M
R
P
T
F
L
E
-
I
V
N
L
L
K
D
D
L
H
P
S
F
57
PsiBlast_CBE
69.36
37%
-119
- C1 -
4IBM
1
?
B:
[10-289]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
E
W
E
---
V
S
R
E
K
I
T
L
L
R
-
E
L
G
Q
G
S
F
G
M
V
Y
---
E
G
N
---
A
R
D
I
I
---------
K
G
E
A
E
T
R
V
A
V
K
T
V
N
E
S
A
S
L
R
E
R
I
E
F
L
N
E
A
S
V
M
K
G
F
-
T
C
-
H
H
V
V
R
L
L
G
V
V
S
----
P
T
L
V
V
M
E
L
M
A
H
G
D
L
K
S
Y
L
R
S
L
R
P
E
----
A
E
N
N
P
G
R
------
P
P
-
P
T
L
Q
E
M
I
Q
M
A
A
E
I
A
D
G
M
A
Y
L
N
A
K
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
-----
H
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
T
D
-
Y
Y
R
K
G
G
K
G
L
L
P
V
R
W
M
A
P
E
S
L
K
D
G
V
F
T
T
S
S
D
M
W
S
F
G
V
V
L
W
E
I
T
S
L
A
E
-
Q
P
Y
Q
G
L
S
N
-
E
Q
V
L
----
K
F
V
M
D
G
G
---
Y
L
D
Q
P
D
N
C
P
E
R
V
T
D
L
M
R
M
C
W
Q
F
N
P
N
M
R
P
T
F
L
E
-
I
V
N
L
L
K
D
D
L
H
P
S
F
67
PsiBlast_CBE
69.23
37%
-130
- C1 -
3DK3
1
ABL1_MOUSE
A:
[7-262]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
---
M
E
R
T
D
I
T
M
K
H
-
K
L
G
G
G
Q
Y
G
E
V
Y
E
-------------------
G
V
W
K
K
Y
S
-
L
T
V
A
V
K
T
L
K
E
------
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
-
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
-------------------
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
-----
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
-
T
F
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
-
P
Y
P
G
I
D
P
-
S
Q
V
Y
E
L
L
E
K
D
Y
R
-------
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
-
I
H
Q
A
F
E
T
M
F
Q
E
S
S
130
HHSearch
69.08
37%
-125
- C1 -
2PVF
1
A:
[28-315]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
K
W
E
---
F
P
R
D
K
L
T
L
G
K
-
P
L
G
E
G
A
F
G
Q
V
V
M
A
E
A
V
G
---
I
D
K
---------
D
K
P
----
V
T
V
A
V
K
M
L
K
D
D
A
T
E
K
D
L
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
H
-
K
N
I
I
N
L
L
G
A
C
T
Q
D
-
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
A
R
R
P
P
G
M
-
E
Y
S
---
Y
--------
Q
-
M
T
F
K
D
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
-----
E
N
N
V
M
K
I
A
D
F
G
L
A
R
D
I
N
N
I
D
-
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
I
P
V
-
E
E
L
F
K
L
L
K
E
-----
G
H
--
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
-
L
V
E
D
L
D
R
I
L
T
L
T
T
13
PsiBlast_PDB
68.87
44%
-116
- C1 -
4YPS
1
A:
[4-285]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
S
G
I
--
R
V
H
H
---
I
K
R
R
D
I
V
L
K
W
-
E
L
G
E
---
G
K
V
F
L
A
E
C
H
N
LL---
D
--------------
K
-
M
L
V
A
V
K
A
L
----
S
E
S
A
R
Q
D
F
Q
R
E
A
E
L
L
T
M
L
-
Q
H
-
Q
H
I
V
R
F
F
G
V
C
T
E
G
-
R
P
L
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
R
S
H
G
P
D
A
K
-
L
L
A
G
G
E
---
D
V
A
P
G
P
--
L
G
L
G
Q
L
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
G
-----
Q
G
L
V
V
K
I
G
D
--
M
S
R
D
I
Y
S
T
D
-
Y
Y
R
V
---
T
M
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
Y
G
K
-
Q
P
W
Y
Q
L
S
N
-
T
E
A
I
D
C
I
-----
T
Q
G
R
E
--
L
E
R
P
R
A
C
P
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
-
V
H
A
R
L
Q
A
L
A
Q
A
P
P
34
PsiBlast_CBE
68.83
37%
-117
- C1 -
3ETA
1
B:
[12-288]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
---
V
S
R
E
K
I
T
L
L
R
-
E
L
G
Q
G
S
F
G
M
V
Y
---
E
G
N
---
A
R
D
I
I
---------
K
G
E
A
E
T
R
V
A
V
K
T
V
N
E
S
A
S
L
R
E
R
I
E
F
L
N
E
A
S
V
M
K
G
F
-
T
C
-
H
H
V
V
R
L
L
G
V
V
S
K
G
-
Q
P
T
L
V
V
M
E
L
M
A
H
G
D
L
K
S
Y
L
R
S
L
R
P
E
----
A
E
N
N
P
G
R
------
P
P
-
P
T
L
Q
E
M
I
Q
M
A
A
E
I
A
D
G
M
A
Y
L
N
A
K
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
-----
H
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
T
D
-
Y
Y
R
K
--
K
G
L
L
P
V
R
W
M
A
P
E
S
L
K
D
G
V
F
T
T
S
S
D
M
W
S
F
G
V
V
L
W
E
I
T
S
L
A
E
-
Q
P
Y
Q
G
L
S
N
-
E
Q
V
L
----
K
F
V
M
D
G
G
---
Y
L
D
Q
P
D
N
C
P
E
R
V
T
D
L
M
R
M
C
W
Q
F
N
P
K
M
R
P
T
F
L
E
-
I
V
N
L
L
K
D
D
L
H
P
S
F
121
HHSearch
68.72
37%
-118
- C1 -
3CBL
3
A:
[110-371]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
---
L
N
H
E
D
L
V
L
G
E
-
Q
I
G
R
G
N
F
G
E
V
F
S
G
R
L
R
A
-----------------
D
N
---
T
L
V
A
V
K
S
C
R
E
T
L
P
P
D
L
K
A
K
F
L
Q
E
A
R
I
L
K
Q
Y
-
S
H
-
P
N
I
V
R
L
I
G
V
C
T
Q
K
-
Q
P
I
Y
I
V
M
E
L
V
Q
G
G
D
F
L
T
F
L
R
T
E
G
-------------------
A
R
-
L
R
V
K
T
L
L
Q
M
V
G
D
A
A
A
G
M
E
Y
L
E
S
K
C
C
I
H
R
D
L
A
A
R
N
C
L
V
T
-----
E
K
N
V
L
K
I
S
D
F
G
M
S
R
E
E
A
D
G
V
-
Y
A
A
S
G
G
L
R
Q
V
P
V
K
W
T
A
P
E
A
L
N
Y
G
R
Y
S
S
E
S
D
V
W
S
F
G
I
L
L
W
E
T
F
S
L
G
-
A
S
P
Y
P
N
L
S
N
-
Q
Q
T
R
E
F
V
----
E
-
K
G
G
--
R
L
P
C
P
E
L
C
P
D
A
V
F
R
L
M
E
Q
C
W
A
Y
E
P
G
Q
R
P
S
F
S
T
-
I
Y
Q
E
L
Q
S
I
R
K
R
H
-
17
PsiBlast_PDB
68.69
45%
-121
- C1 -
4PMP
1
A:
[5-278]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
K
R
R
D
I
V
L
K
W
-
E
L
G
E
G
A
F
G
K
V
F
L
A
E
C
H
N
LL------------------
K
-
M
L
V
A
V
K
A
L
K
-----
S
A
R
Q
D
F
Q
R
E
A
E
L
L
T
M
L
-
Q
H
-
Q
H
I
V
R
F
F
G
V
C
T
E
G
-
R
P
L
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
R
S
H
G
P
D
A
K
-
L
L
A
G
G
E
---
D
V
A
P
G
P
--
L
G
L
G
Q
L
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
G
-----
Q
G
L
V
V
K
I
G
D
F
G
M
S
R
-
I
Y
S
T
D
-
Y
Y
R
V
G
--
T
M
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
Y
G
K
-
Q
P
W
Y
Q
L
S
N
-
T
E
A
I
D
C
I
-----
T
Q
G
R
E
--
L
E
R
P
R
A
C
P
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
-
V
H
A
R
L
Q
A
L
A
Q
A
H
H
35
PsiBlast_CBE
68.55
37%
-117
- C1 -
3ETA
1
INSR_HUMAN
A:
[12-288]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
---
V
S
R
E
K
I
T
L
L
R
-
E
L
G
Q
G
S
F
G
M
V
Y
---
E
G
N
---
A
R
D
I
I
---------
K
G
E
A
E
T
R
V
A
V
K
T
V
N
E
S
A
S
L
R
E
R
I
E
F
L
N
E
A
S
V
M
K
G
F
-
T
C
-
H
H
V
V
R
L
L
G
V
V
S
K
G
-
Q
P
T
L
V
V
M
E
L
M
A
H
G
D
L
K
S
Y
L
R
S
L
R
P
E
----
A
E
N
N
P
G
R
------
P
P
-
P
T
L
Q
E
M
I
Q
M
A
A
E
I
A
D
G
M
A
Y
L
N
A
K
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
-----
H
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
T
D
-
Y
Y
R
K
G
-
K
G
L
L
P
V
R
W
M
A
P
E
S
L
K
D
G
V
F
T
T
S
S
D
M
W
S
F
G
V
V
L
W
E
I
T
S
L
A
E
-
Q
P
Y
Q
G
L
S
N
-
E
Q
V
L
----
K
F
V
M
D
G
G
---
Y
L
D
Q
P
D
N
C
P
E
R
V
T
D
L
M
R
M
C
W
Q
F
N
P
K
M
R
P
T
F
L
E
-
I
V
N
L
L
K
D
D
L
H
P
S
F
52
PsiBlast_CBE
68.18
37%
-121
- C1 -
1IEP
1
ABL1_MOUSE
A:
[3-269]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
D
P
S
S
--
P
N
Y
D
KWE
M
E
R
T
D
I
T
M
K
H
-
K
L
G
G
G
Q
Y
G
E
V
Y
E
-------------------
G
V
W
K
K
Y
S
-
L
T
V
A
V
K
T
L
K
E
D
T
M
E
--
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
-
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
------------------
R
E
C
N
R
Q
E
-
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
-----
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
-
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
-
P
Y
P
G
I
D
L
-
S
Q
V
Y
E
L
L
E
K
D
Y
R
-------
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
-
I
H
Q
A
F
E
T
M
F
Q
---
31
PsiBlast_CBE
68.15
37%
-126
- C1 -
2QOH
1
ABL1_MOUSE
B:
[1-264]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
S
--
P
N
Y
D
KWE
M
E
R
T
D
I
T
M
K
H
-
K
L
G
G
G
Q
Y
G
E
V
Y
E
-------------------
G
V
W
K
K
Y
S
-
L
T
V
A
V
K
T
L
K
---
M
E
--
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
-
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
-------------------
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
-----
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
-
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
-
P
Y
P
G
I
D
L
-
S
Q
V
Y
E
L
L
E
K
D
Y
R
-------
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
-
I
H
Q
A
F
E
T
M
F
Q
E
S
S
125
HHSearch
68.13
37%
-123
- C1 -
4CLJ
1
A:
[23-300]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
L
K
E
---
V
P
R
K
N
I
T
L
I
R
-
G
L
G
H
G
A
F
G
E
V
Y
E
G
Q
V
S
---------------------
P
-
L
Q
V
A
V
K
T
L
P
E
V
C
S
E
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
-
N
H
-
Q
N
I
V
R
C
I
G
V
S
L
Q
S
-
L
P
R
F
I
L
M
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
P
R
-------------
P
S
Q
P
S
S
-
L
A
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
CPG--
P
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
-------
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
Y
M
P
Y
P
S
K
S
N
-
Q
E
V
L
E
F
V
----
T
S
G
G
R
---
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
-
I
L
E
R
I
E
Y
C
T
Q
D
P
D
89
PsiBlast_CBE
68.10
37%
-124
- C1 -
1OPL
1
ABL1_HUMAN
B:
[255-510]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
---
M
E
R
T
D
I
T
M
K
H
-
K
L
G
G
G
Q
Y
G
E
V
Y
E
-------------------
G
V
W
K
K
Y
S
-
L
T
V
A
V
K
T
L
K
E
D
T
M
E
--
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
-
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
-------------------
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
N
L
A
A
R
N
C
L
V
G
-----
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
-
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
-
P
Y
P
G
I
D
L
-
S
Q
V
Y
E
L
L
E
K
D
Y
R
-------
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
-
I
H
Q
A
F
E
T
M
F
Q
E
--
93
PsiBlast_CBE
68.08
37%
-125
- C1 -
2G2H
1
ABL1_HUMAN
B:
[11-266]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
---
M
E
R
T
D
I
T
M
K
H
-
K
L
G
G
G
Q
Y
G
E
V
Y
E
-------------------
G
V
W
K
K
Y
S
-
L
T
V
A
V
K
T
L
K
E
D
T
M
E
--
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
-
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
-------------------
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
-----
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
-
T
Y
T
A
P
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
-
P
Y
P
G
I
D
L
-
S
Q
V
Y
E
L
L
E
K
D
Y
R
-------
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
-
I
H
Q
A
F
E
T
M
F
Q
E
S
S
94
PsiBlast_CBE
67.97
37%
-122
- C1 -
2G2H
1
ABL1_HUMAN
A:
[11-266]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
---
M
E
R
T
D
I
T
M
K
H
-
K
L
G
G
G
Q
Y
G
E
V
Y
E
-------------------
G
V
W
K
K
Y
S
-
L
T
V
A
V
K
T
L
K
E
D
T
M
E
--
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
-
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
-------------------
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
-----
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
-
T
Y
T
A
P
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
-
P
Y
P
G
I
D
L
-
S
Q
V
Y
E
L
L
E
K
D
Y
R
-------
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
-
I
H
Q
A
F
E
T
M
F
Q
E
S
S
59
PsiBlast_CBE
67.81
37%
-124
- C1 -
1OPK
3
ABL1_MOUSE
A:
[216-471]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
---
M
E
R
T
D
I
T
M
K
H
-
K
L
G
G
G
Q
Y
G
E
V
Y
E
-------------------
G
V
W
K
K
Y
S
-
L
T
V
A
V
K
T
L
K
E
D
T
M
E
--
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
-
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
-------------------
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
N
L
A
A
R
N
C
L
V
G
-----
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
-
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
-
P
Y
P
G
I
D
L
-
S
Q
V
Y
E
L
L
E
K
D
Y
R
-------
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
-
I
H
Q
A
F
E
T
M
F
Q
E
S
S
102
PsiBlast_CBE
67.72
37%
-129
- C1 -
3CS9
1
ABL1_HUMAN
B:
[13-268]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
---
M
E
R
T
D
I
T
M
K
H
-
K
L
G
G
G
Q
Y
G
E
V
Y
E
-------------------
G
V
W
K
K
Y
S
-
L
T
V
A
V
K
T
L
---
T
M
E
--
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
-
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
-------------------
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
-----
E
N
H
L
V
K
V
A
D
F
G
--------------------
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
-
P
Y
P
G
I
D
L
-
S
Q
V
Y
E
L
L
E
K
D
Y
R
-------
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
-
I
H
Q
A
F
E
T
M
F
Q
E
S
-
30
PsiBlast_CBE
67.72
37%
-128
- C1 -
3KF4
1
ABL1_MOUSE
A:
[2-264]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
--
P
N
Y
D
KWE
M
E
R
T
D
I
T
M
K
H
-
K
L
G
G
G
Q
Y
G
E
V
Y
E
-------------------
G
V
W
K
K
Y
S
-
L
T
V
A
V
K
T
L
K
-------
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
-
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
-------------------
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
-----
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
-
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
-
P
Y
P
G
I
D
L
-
S
Q
V
Y
E
L
L
E
K
D
Y
R
-------
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
-
I
H
Q
A
F
E
T
M
F
Q
E
S
S
80
PsiBlast_CBE
67.59
37%
-124
- C1 -
3IK3
1
ABL1_MOUSE
B:
[1-264]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
S
--
P
N
Y
D
KWE
M
E
R
T
D
I
T
M
K
H
-
K
L
G
G
G
Q
Y
G
E
V
Y
E
-------------------
G
V
W
K
K
Y
S
-
L
T
V
A
V
K
T
L
K
E
D
T
M
E
--
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
-
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
-------------------
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
-----
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
-
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
-
P
Y
P
G
I
D
L
-
S
Q
V
Y
E
L
L
E
K
D
Y
R
-------
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
-
I
H
Q
A
F
E
T
M
F
Q
E
S
S
48
PsiBlast_CBE
67.58
37%
-122
- C1 -
1OPJ
2
ABL1_MOUSE
A:
[2-269]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
M
D
P
S
S
--
P
N
Y
D
KWE
M
E
R
T
D
I
T
M
K
H
-
K
L
G
G
G
Q
Y
G
E
V
Y
E
-------------------
G
V
W
K
K
Y
S
-
L
T
V
A
V
K
T
L
K
E
D
T
M
E
--
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
-
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
------------------
R
E
C
N
R
Q
E
-
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
-----
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
-
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
-
P
Y
P
G
I
D
L
-
S
Q
V
Y
E
L
L
E
K
D
Y
R
-------
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
-
I
H
Q
A
F
E
T
M
F
Q
E
S
S
47
PsiBlast_CBE
67.58
37%
-126
- C1 -
1OPJ
2
ABL1_MOUSE
B:
[3-269]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
D
P
S
S
--
P
N
Y
D
KWE
M
E
R
T
D
I
T
M
K
H
-
K
L
G
G
G
Q
Y
G
E
V
Y
E
-------------------
G
V
W
K
K
Y
S
-
L
T
V
A
V
K
T
L
K
E
D
T
M
E
--
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
-
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
------------------
R
E
C
N
R
Q
E
-
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
-----
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
-
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
-
P
Y
P
G
I
D
L
-
S
Q
V
Y
E
L
L
E
K
D
Y
R
-------
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
-
I
H
Q
A
F
E
T
M
F
Q
E
S
S
126
HHSearch
67.56
37%
-123
- C1 -
3L9P
4
A:
[65-341]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
E
---
V
P
R
K
N
I
T
L
I
R
-
G
L
G
H
G
A
F
G
E
V
Y
E
G
Q
V
S
G
-------------------
S
P
-
L
Q
V
A
V
K
T
L
P
E
V
C
S
E
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
-
N
H
-
Q
N
I
V
R
C
I
G
V
S
L
Q
S
-
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
P
R
P
-------------
S
Q
P
S
S
-
L
A
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
CPG--
P
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
A
G
-
Y
Y
R
K
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
Y
M
P
Y
P
S
K
S
N
-
Q
E
V
L
E
F
V
T
----
S
G
G
---
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
-
I
L
E
R
I
E
Y
C
T
Q
D
P
D
49
PsiBlast_CBE
67.40
37%
-121
- C1 -
1M52
3
ABL1_MOUSE
B:
[10-269]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
D
KWE
M
E
R
T
D
I
T
M
K
H
-
K
L
G
G
G
Q
Y
G
E
V
Y
E
-------------------
G
V
W
K
K
Y
S
-
L
T
V
A
V
K
T
L
K
E
D
T
M
E
--
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
-
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
------------------
R
E
C
N
R
Q
E
-
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
-----
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
-
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
-
P
Y
P
G
I
D
L
-
S
Q
V
Y
E
L
L
E
K
D
Y
R
-------
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
-
I
H
Q
A
F
E
T
M
F
Q
E
S
S
50
PsiBlast_CBE
67.34
37%
-124
- C1 -
1M52
1
ABL1_MOUSE
A:
[10-269]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
D
KWE
M
E
R
T
D
I
T
M
K
H
-
K
L
G
G
G
Q
Y
G
E
V
Y
E
-------------------
G
V
W
K
K
Y
S
-
L
T
V
A
V
K
T
L
K
E
D
T
M
E
--
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
-
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
------------------
R
E
C
N
R
Q
E
-
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
-----
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
-
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
-
P
Y
P
G
I
D
L
-
S
Q
V
Y
E
L
L
E
K
D
Y
R
-------
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
-
I
H
Q
A
F
E
T
M
F
Q
E
S
S
82
PsiBlast_CBE
67.32
37%
-126
- C1 -
2Z60
1
ABL1_MOUSE
A:
[1-264]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
S
--
P
N
Y
D
KWE
M
E
R
T
D
I
T
M
K
H
-
K
L
G
G
G
Q
Y
G
E
V
Y
E
-------------------
G
V
W
K
K
Y
S
-
L
T
V
A
V
K
T
L
K
E
---
E
--
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
-
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
-------------------
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
-----
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
-
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
-
P
Y
P
G
I
D
L
-
S
Q
V
Y
E
L
L
E
K
D
Y
R
-------
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
-
I
H
Q
A
F
E
T
M
F
Q
E
S
S
98
PsiBlast_CBE
67.28
37%
-124
- C1 -
2F4J
1
ABL1_HUMAN
A:
[10-265]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
---
M
E
R
T
D
I
T
M
K
H
-
K
L
G
G
G
Q
Y
G
E
V
Y
E
-------------------
G
V
W
K
K
Y
S
-
L
T
V
A
V
K
T
L
K
E
D
T
M
E
--
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
-
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
-------------------
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
-----
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
-
T
Y
T
A
P
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
-
P
Y
P
G
I
D
L
-
S
Q
V
Y
E
L
L
E
K
D
Y
R
-------
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
-
I
H
Q
A
F
E
T
M
F
Q
E
S
S
105
PsiBlast_CBE
67.17
37%
-126
- C1 -
2HZI
1
ABL1_HUMAN
A:
[13-268]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
---
M
E
R
T
D
I
T
M
K
H
-
K
L
G
G
G
Q
Y
G
E
V
Y
E
-------------------
G
V
W
K
K
Y
S
-
L
T
V
A
V
K
T
L
K
E
D
T
M
E
--
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
-
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
-------------------
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
-----
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
-
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
-
P
Y
P
G
I
D
L
-
S
Q
V
Y
E
L
L
E
K
D
Y
R
-------
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
-
I
H
Q
A
F
E
T
M
F
Q
E
S
-
28
PsiBlast_CBE
67.12
37%
-120
- C1 -
3KFA
1
ABL1_MOUSE
A:
[1-264]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
S
--
P
N
Y
D
KWE
M
E
R
T
D
I
T
M
K
H
-
K
L
G
G
G
Q
Y
G
E
V
Y
E
-------------------
G
V
W
K
K
Y
S
-
L
T
V
A
V
K
T
L
K
E
D
T
M
E
--
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
-
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
-------------------
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
-----
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
-
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
-
P
Y
P
G
I
D
L
-
S
Q
V
Y
E
L
L
E
K
D
Y
R
-------
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
-
I
H
Q
A
F
E
T
M
F
Q
E
S
S
88
PsiBlast_CBE
67.08
37%
-127
- C1 -
4TWP
1
ABL1_HUMAN
B:
[4-259]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
---
M
E
R
T
D
I
T
M
K
H
-
K
L
G
G
G
Q
Y
G
E
V
Y
E
-------------------
G
V
W
K
K
Y
S
-
L
T
V
A
V
K
T
L
K
E
D
T
M
E
--
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
-
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
-------------------
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
-----
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
-
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
-
P
Y
P
G
I
D
L
-
S
Q
V
Y
E
L
L
E
K
D
Y
R
-------
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
-
I
H
Q
A
F
E
T
M
F
Q
E
S
S
104
PsiBlast_CBE
67.04
37%
-129
- C1 -
2HZI
1
ABL1_HUMAN
B:
[13-268]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
---
M
E
R
T
D
I
T
M
K
H
-
K
L
G
G
G
Q
Y
G
E
V
Y
E
-------------------
G
V
W
K
K
Y
S
-
L
T
V
A
V
K
T
L
----
M
E
--
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
-
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
-------------------
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
-----
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
-
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
-
P
Y
P
G
I
D
L
-
S
Q
V
Y
E
L
L
E
K
D
Y
R
-------
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
-
I
H
Q
A
F
E
T
M
F
Q
E
S
-
44
PsiBlast_CBE
67.03
37%
-125
- C1 -
3K5V
2
ABL1_MOUSE
B:
[3-269]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
D
P
S
S
--
P
N
Y
D
KWE
M
E
R
T
D
I
T
M
K
H
-
K
L
G
G
G
Q
Y
G
E
V
Y
E
-------------------
G
V
W
K
K
Y
S
-
L
T
V
A
V
K
T
L
K
---
M
E
--
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
-
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
------------------
R
E
C
N
R
Q
E
-
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
-----
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
-
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
-
P
Y
P
G
I
D
L
-
S
Q
V
Y
E
L
L
E
K
D
Y
R
-------
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
-
I
H
Q
A
F
E
T
M
F
Q
E
S
S
70
PsiBlast_CBE
67.00
36%
-126
- C1 -
4XEY
1
ABL1_HUMAN
A:
[116-376]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NY
D
K
W
E
---
M
E
R
T
D
I
T
M
K
H
-
K
L
G
G
----
E
V
Y
E
-------------------
G
V
W
K
K
Y
S
-
L
T
V
A
V
K
T
L
K
E
D
T
M
E
--
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
-
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
------------------
R
E
C
N
R
Q
E
-
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
-----
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
-
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
-
P
Y
P
G
I
D
L
-
S
Q
V
Y
E
L
L
E
K
D
Y
R
-------
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
-
I
H
Q
A
F
E
T
M
F
Q
E
S
S
42
PsiBlast_CBE
66.98
37%
-125
- C1 -
3MS9
2
ABL1_MOUSE
B:
[2-269]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
M
D
P
S
S
--
P
N
Y
D
KWE
M
E
R
T
D
I
T
M
K
H
-
K
L
G
G
G
Q
Y
G
E
V
Y
E
-------------------
G
V
W
K
K
Y
S
-
L
T
V
A
V
K
T
L
---
T
M
E
--
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
-
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
------------------
R
E
C
N
R
Q
E
-
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
-----
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
-
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
-
P
Y
P
G
I
D
L
-
S
Q
V
Y
E
L
L
E
K
D
Y
R
-------
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
-
I
H
Q
A
F
E
T
M
F
Q
---
36
PsiBlast_CBE
66.94
37%
-131
- C1 -
3PYY
3
ABL1_HUMAN
B:
[19-277]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
KWE
M
E
R
T
D
I
T
M
K
H
-
K
L
G
G
G
Q
Y
G
E
V
Y
E
-------------------
G
V
W
K
K
Y
S
-
L
T
V
A
V
K
T
L
--------
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
-
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
-------------------
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
-----
E
N
H
L
V
K
V
A
D
F
-----------------
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
-
P
Y
P
G
I
D
L
-
S
Q
V
Y
E
L
L
E
K
D
Y
R
-------
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
-
I
H
Q
A
F
E
T
M
F
Q
E
S
S
132
HHSearch
66.86
34%
-121
- C1 -
2XIR
1
A:
[22-307]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
---
F
P
R
D
R
L
K
L
G
K
-
P
L
G
R
G
A
F
G
Q
V
I
E
A
D
A
F
G
---
I
D
K
-----------
T
A
T
C
-
R
T
V
A
V
K
M
L
K
E
G
A
T
H
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
-
G
H
H
L
N
V
V
N
L
L
G
A
C
T
K
P
G
G
P
L
M
V
I
V
E
F
C
K
F
G
N
L
S
T
Y
L
R
S
K
R
N
E
F
V
-
P
Y
----------
Y
K
D
F
-
L
T
L
E
H
L
I
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
-----
E
K
N
V
V
K
I
C
D
F
G
L
A
R
D
I
Y
K
D
P
-
D
Y
V
R
K
G
D
A
R
L
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
A
S
P
Y
P
G
V
K
I
D
E
E
F
C
R
R
L
K
----
E
-
G
--
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
-
L
V
E
H
L
G
N
L
L
Q
A
N
A
128
HHSearch
66.83
36%
-115
- C1 -
2I1M
1
A:
[40-326]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
E
---
F
P
R
N
N
L
Q
F
G
K
-
T
L
G
A
G
A
F
G
K
V
V
E
A
T
A
F
G
---
L
G
-----------
K
E
D
A
V
-
L
K
V
A
V
K
M
L
K
S
T
A
H
A
D
E
K
E
A
L
M
S
E
L
K
I
M
S
H
L
G
Q
H
-
E
N
I
V
N
L
L
G
A
C
T
H
G
-
G
P
V
L
V
I
T
E
Y
C
C
Y
G
D
L
L
N
F
L
R
R
K
S
R
V
L
E
-
T
D
------------
S
T
-
A
S
T
R
D
L
L
H
F
S
S
Q
V
A
Q
G
M
A
F
L
A
S
K
N
C
I
H
R
D
V
A
A
R
N
V
L
L
T
-----
N
G
H
V
A
K
I
G
D
F
G
L
A
R
D
I
M
N
D
S
-
N
Y
I
V
K
G
N
A
R
L
P
V
K
W
M
A
P
E
S
I
F
D
C
V
Y
T
V
Q
S
D
V
W
S
Y
G
I
L
L
W
E
I
F
S
L
-
G
L
N
P
Y
P
G
I
L
V
-
N
S
K
F
Y
K
L
---
V
K
-
D
G
Y
--
Q
M
A
Q
P
A
F
A
P
K
N
I
Y
S
I
M
Q
A
C
W
A
L
E
P
T
H
R
P
T
F
Q
Q
-
I
C
S
F
L
Q
E
Q
A
Q
E
D
R
66
PsiBlast_CBE
66.83
37%
-127
- C1 -
3DK3
1
ABL1_MOUSE
B:
[7-262]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
---
M
E
R
T
D
I
T
M
K
H
-
K
L
G
G
G
Q
Y
G
E
V
Y
E
-------------------
G
V
W
K
K
Y
S
-
L
T
V
A
V
K
T
L
----
M
E
--
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
-
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
-------------------
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
-----
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
-
T
F
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
-
P
Y
P
G
I
D
P
-
S
Q
V
Y
E
L
L
E
K
D
Y
R
-------
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
-
I
H
Q
A
F
E
T
M
F
Q
E
S
S
135
HHSearch
66.78
35%
-123
- C1 -
4CKJ
16
A:
[15-309]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
--
P
K
W
E
---
F
P
R
K
N
L
V
L
G
K
-
T
L
G
E
G
E
F
G
K
V
V
K
A
T
A
F
H
---
L
K
G
-----------
R
A
G
Y
-
T
T
V
A
V
K
M
L
K
E
N
A
S
P
S
E
L
R
D
L
L
S
E
F
N
V
L
K
Q
V
-
N
H
-
P
H
V
I
K
L
Y
G
A
C
S
Q
D
-
G
P
L
L
L
I
V
E
Y
A
K
Y
G
S
L
R
G
F
L
R
E
S
R
K
V
-----------------
R
A
-
L
T
M
G
D
L
I
S
F
A
W
Q
I
S
Q
G
M
Q
Y
L
A
E
M
K
L
V
H
R
D
L
A
A
R
N
I
L
V
A
-----
E
G
R
K
M
K
I
S
D
F
G
L
S
R
D
V
Y
E
E
D
-
S
Y
V
K
R
S
Q
G
R
I
P
V
K
W
M
A
I
E
S
L
F
D
H
I
Y
T
T
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
V
T
L
-
G
G
N
P
Y
P
G
I
P
P
-
E
R
L
F
N
L
L
K
T
-----
G
H
--
R
M
E
R
P
D
N
C
S
E
E
M
Y
R
L
M
L
Q
C
W
K
Q
E
P
D
K
R
P
V
F
A
D
-
I
S
K
D
L
E
K
M
M
V
K
R
R
81
PsiBlast_CBE
66.60
37%
-125
- C1 -
3IK3
1
ABL1_MOUSE
A:
[1-264]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
S
--
P
N
Y
D
KWE
M
E
R
T
D
I
T
M
K
H
-
K
L
G
G
G
Q
Y
G
E
V
Y
E
-------------------
G
V
W
K
K
Y
S
-
L
T
V
A
V
K
T
L
K
E
D
T
M
E
--
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
-
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
-------------------
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
-----
E
N
H
L
V
K
V
A
D
F
G
L
S
--------
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
-
P
Y
P
G
I
D
L
-
S
Q
V
Y
E
L
L
E
K
D
Y
R
-------
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
-
I
H
Q
A
F
E
T
M
F
Q
E
S
S
90
PsiBlast_CBE
66.56
37%
-124
- C1 -
1OPL
2
ABL1_HUMAN
A:
[255-510]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
---
M
E
R
T
D
I
T
M
K
H
-
K
L
G
G
G
Q
Y
G
E
V
Y
E
-------------------
G
V
W
K
K
Y
S
-
L
T
V
A
V
K
T
L
K
E
D
T
M
E
--
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
-
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
-------------------
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
N
L
A
A
R
N
C
L
V
G
-----
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
-
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
-
P
Y
P
G
I
D
L
-
S
Q
V
Y
E
L
L
E
K
D
Y
R
-------
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
-
I
H
Q
A
F
E
T
M
F
Q
E
S
S
27
PsiBlast_CBE
66.49
37%
-119
- C1 -
3KFA
1
ABL1_MOUSE
B:
[1-264]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
S
--
P
N
Y
D
KWE
M
E
R
T
D
I
T
M
K
H
-
K
L
G
G
G
Q
Y
G
E
V
Y
E
-------------------
G
V
W
K
K
Y
S
-
L
T
V
A
V
K
T
L
K
E
D
T
M
E
--
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
-
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
-------------------
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
-----
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
-
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
-
P
Y
P
G
I
D
L
-
S
Q
V
Y
E
L
L
E
K
D
Y
R
-------
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
-
I
H
Q
A
F
E
T
M
F
Q
E
S
S
64
PsiBlast_CBE
66.43
37%
-122
- C1 -
2G1T
1
ABL1_HUMAN
B:
[11-266]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
---
M
E
R
T
D
I
T
M
K
H
-
K
L
G
G
G
Q
Y
G
E
V
Y
E
-------------------
G
V
W
K
K
Y
S
-
L
T
V
A
V
K
T
L
K
E
D
T
M
E
--
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
-
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
-------------------
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
-----
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
-
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
-
P
Y
P
G
I
D
L
-
S
Q
V
Y
E
L
L
E
K
D
Y
R
-------
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
-
I
H
Q
A
F
E
T
M
F
Q
E
S
S
60
PsiBlast_CBE
66.41
37%
-128
- C1 -
3UE4
1
ABL1_HUMAN
B:
[11-266]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
---
M
E
R
T
D
I
T
M
K
H
-
K
L
G
G
G
--
G
E
V
Y
E
-------------------
G
V
W
K
K
Y
S
-
L
T
V
A
V
K
T
L
K
E
D
T
M
E
--
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
-
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
-------------------
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
-----
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
-
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
-
P
Y
P
G
I
D
L
-
S
Q
V
Y
E
L
L
E
K
D
Y
R
-------
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
-
I
H
Q
A
F
E
T
M
F
Q
E
S
S
96
PsiBlast_CBE
66.39
37%
-121
- C1 -
2G2F
1
ABL1_HUMAN
A:
[11-266]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
---
M
E
R
T
D
I
T
M
K
H
-
K
L
G
G
G
Q
Y
G
E
V
Y
E
-------------------
G
V
W
K
K
Y
S
-
L
T
V
A
V
K
T
L
K
E
D
T
M
E
--
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
-
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
-------------------
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
-----
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
-
T
Y
T
A
P
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
-
P
Y
P
G
I
D
L
-
S
Q
V
Y
E
L
L
E
K
D
Y
R
-------
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
-
I
H
Q
A
F
E
T
M
F
Q
E
S
S
29
PsiBlast_CBE
66.38
37%
-127
- C1 -
3KF4
1
ABL1_MOUSE
B:
[2-264]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
--
P
N
Y
D
KWE
M
E
R
T
D
I
T
M
K
H
-
K
L
G
G
G
Q
Y
G
E
V
Y
E
-------------------
G
V
W
K
K
Y
S
-
L
T
V
A
V
K
T
L
---
T
M
E
--
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
-
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
-------------------
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
-----
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
-
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
-
P
Y
P
G
I
D
L
-
S
Q
V
Y
E
L
L
E
K
D
Y
R
-------
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
-
I
H
Q
A
F
E
T
M
F
Q
E
S
S
18
PsiBlast_PDB
66.15
45%
-118
- C1 -
4PMT
1
A:
[5-278]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
K
R
R
D
I
V
L
K
W
-
E
L
G
E
G
A
F
G
K
V
F
L
A
E
C
H
N
L----
D
--------------
K
-
M
L
V
A
V
K
A
L
----------
D
F
Q
R
E
A
E
L
L
T
M
L
-
Q
H
-
Q
H
I
V
R
F
F
G
V
C
T
E
G
-
R
P
L
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
R
S
H
G
P
D
A
K
-
L
L
A
G
G
E
---
D
V
A
P
G
P
--
L
G
L
G
Q
L
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
G
-----
Q
G
L
V
V
K
I
G
D
F
--
S
R
D
I
Y
S
T
D
-
Y
Y
R
V
---
T
M
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
Y
G
K
-
Q
P
W
Y
Q
L
S
N
-
T
E
A
I
D
C
I
-----
T
Q
G
R
E
--
L
E
R
P
R
A
C
P
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
-
V
H
A
R
L
Q
A
L
A
Q
A
H
H
65
PsiBlast_CBE
66.00
37%
-126
- C1 -
2G1T
1
ABL1_HUMAN
A:
[11-266]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
---
M
E
R
T
D
I
T
M
K
H
-
K
L
G
G
G
Q
Y
G
E
V
Y
E
-------------------
G
V
W
K
K
Y
S
-
L
T
V
A
V
K
T
L
K
E
D
T
M
E
--
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
-
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
-------------------
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
-----
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
-
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
-
P
Y
P
G
I
D
L
-
S
Q
V
Y
E
L
L
E
K
D
Y
R
-------
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
-
I
H
Q
A
F
E
T
M
F
Q
E
S
S
62
PsiBlast_CBE
65.98
37%
-122
- C1 -
2G1T
1
ABL1_HUMAN
D:
[11-266]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
---
M
E
R
T
D
I
T
M
K
H
-
K
L
G
G
G
Q
Y
G
E
V
Y
E
-------------------
G
V
W
K
K
Y
S
-
L
T
V
A
V
K
T
L
K
E
D
T
M
E
--
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
-
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
-------------------
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
-----
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
-
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
-
P
Y
P
G
I
D
L
-
S
Q
V
Y
E
L
L
E
K
D
Y
R
-------
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
-
I
H
Q
A
F
E
T
M
F
Q
E
S
S
100
PsiBlast_CBE
65.97
37%
-126
- C1 -
3QRI
1
ABL1_HUMAN
A:
[14-269]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
---
M
E
R
T
D
I
T
M
K
H
-
K
L
G
G
G
Q
Y
G
E
V
Y
E
-------------------
G
V
W
K
K
Y
S
-
L
T
V
A
V
K
T
L
K
E
D
T
M
E
--
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
-
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
------------------
R
E
C
N
R
Q
E
-
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
-----
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
-
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
-
P
Y
P
G
I
D
L
-
S
Q
V
Y
E
L
L
E
K
D
Y
R
-------
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
-
I
H
Q
A
F
E
T
M
F
Q
---
101
PsiBlast_CBE
65.92
37%
-120
- C1 -
3CS9
1
ABL1_HUMAN
D:
[13-268]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
---
M
E
R
T
D
I
T
M
K
H
-
K
L
G
G
G
Q
Y
G
E
V
Y
E
-------------------
G
V
W
------
T
V
A
V
K
T
L
K
E
D
T
M
E
--
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
-
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
-------------------
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
-----
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
-
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
-
P
Y
P
G
I
D
L
-
S
Q
V
Y
E
L
L
E
K
D
Y
R
-------
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
-
I
H
Q
A
F
E
T
M
F
Q
E
S
-
72
PsiBlast_CBE
65.76
37%
-129
- C1 -
2HZ4
1
ABL1_HUMAN
B:
[9-264]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
---
M
E
R
T
D
I
T
M
K
H
-
K
L
G
-----
E
V
Y
E
-------------------
G
V
W
K
K
Y
S
-
L
T
V
A
V
K
T
L
K
E
D
T
M
E
--
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
-
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
-------------------
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
-----
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
-
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
-
P
Y
P
G
I
D
L
-
S
Q
V
Y
E
L
L
E
K
D
Y
R
-------
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
-
I
H
Q
A
F
E
T
M
F
Q
---
54
PsiBlast_CBE
65.70
37%
-118
- C1 -
1FPU
1
ABL1_MOUSE
A:
[3-269]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
D
P
S
S
--
P
N
Y
D
KWE
M
E
R
T
D
I
T
M
K
H
-
K
L
G
G
G
Q
Y
G
E
V
Y
E
-------------------
G
V
W
K
K
Y
S
-
L
T
V
A
V
K
T
L
K
E
D
T
M
E
--
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
-
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
------------------
R
E
C
N
R
Q
E
-
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
-----
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
-
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
-
P
Y
P
G
I
D
L
-
S
Q
V
Y
E
L
L
E
K
D
Y
R
-------
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
-
I
H
Q
A
F
E
T
M
F
Q
E
--
87
PsiBlast_CBE
65.68
37%
-123
- C1 -
2FO0
3
ABL1_HUMAN
A:
[213-468]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
---
M
E
R
T
D
I
T
M
K
H
-
K
L
G
G
G
Q
Y
G
E
V
Y
E
-------------------
G
V
W
K
K
Y
S
-
L
T
V
A
V
K
T
L
K
E
D
T
M
E
--
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
-
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
-------------------
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
N
L
A
A
R
N
C
L
V
G
-----
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
-
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
-
P
Y
P
G
I
D
L
-
S
Q
V
Y
E
L
L
E
K
D
Y
R
-------
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
-
I
H
Q
A
F
E
T
M
F
Q
E
S
S
32
PsiBlast_CBE
65.64
37%
-126
- C1 -
2QOH
1
ABL1_MOUSE
A:
[1-264]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
S
--
P
N
Y
D
KWE
M
E
R
T
D
I
T
M
K
H
-
K
L
G
G
G
Q
Y
G
E
V
Y
E
-------------------
G
V
W
K
K
Y
S
-
L
T
V
A
V
K
T
L
K
E
---
E
--
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
-
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
-------------------
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
-----
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
-
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
-
P
Y
P
G
I
D
L
-
S
Q
V
Y
E
L
L
E
K
D
Y
R
-------
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
-
I
H
Q
A
F
E
T
M
F
Q
E
S
S
99
PsiBlast_CBE
65.56
37%
-125
- C1 -
3QRK
1
ABL1_HUMAN
A:
[14-269]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
---
M
E
R
T
D
I
T
M
K
H
-
K
L
G
G
G
Q
Y
G
E
V
Y
E
-------------------
G
V
W
K
K
Y
S
-
L
T
V
A
V
K
T
L
K
E
D
T
M
E
--
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
-
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
------------------
R
E
C
N
R
Q
E
-
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
-----
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
-
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
-
P
Y
P
G
I
D
L
-
S
Q
V
Y
E
L
L
E
K
D
Y
R
-------
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
-
I
H
Q
A
F
E
T
M
-----
41
PsiBlast_CBE
65.52
36%
-119
- C1 -
2HIW
1
ABL1_HUMAN
A:
[1-266]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
A
M
D
P
N
Y
--
D
K
W
E
---
M
E
R
T
D
I
T
M
K
H
-
K
L
G
G
G
Q
Y
G
E
V
Y
E
-------------------
G
V
W
K
K
Y
S
-
L
T
V
A
V
K
T
L
K
E
D
T
M
E
--
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
-
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
-------------------
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
-----
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
-
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
-
P
Y
P
G
I
D
L
-
S
Q
V
Y
E
L
L
E
K
D
Y
R
-------
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
-
I
H
Q
A
F
E
T
M
F
Q
E
--
127
HHSearch
65.46
38%
-113
- C1 -
3TT0
1
FGFR1_HUMAN
A:
[63-349]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
W
E
---
L
P
R
D
R
L
V
L
G
K
-
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
---
L
D
K
---------
D
K
P
N
R
V
-
T
K
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
-
K
N
I
I
N
L
L
G
A
C
T
Q
D
-
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
P
P
G
L
-
E
Y
S
--
Y
-
N
P
S
H
N
P
E
E
Q
-
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
-----
E
D
N
V
M
K
I
A
D
F
G
L
A
R
D
I
H
H
I
D
-
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
-
E
E
L
F
K
L
L
K
E
-----
G
H
--
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
-
L
V
E
D
L
D
R
I
V
A
L
T
S
45
PsiBlast_CBE
65.45
37%
-122
- C1 -
3K5V
2
ABL1_MOUSE
A:
[2-269]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
M
D
P
S
S
--
P
N
Y
D
KWE
M
E
R
T
D
I
T
M
K
H
-
K
L
G
G
G
Q
Y
G
E
V
Y
E
-------------------
G
V
W
K
K
Y
S
-
L
T
V
A
V
K
T
L
K
E
D
-
M
E
--
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
-
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
------------------
R
E
C
N
R
Q
E
-
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
-----
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
-
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
-
P
Y
P
G
I
D
L
-
S
Q
V
Y
E
L
L
E
K
D
Y
R
-------
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
-
I
H
Q
A
F
E
T
M
F
Q
E
S
S
83
PsiBlast_CBE
65.43
37%
-121
- C1 -
3OY3
1
ABL1_MOUSE
B:
[1-264]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
S
--
P
N
Y
D
KWE
M
E
R
T
D
I
T
M
K
H
-
K
L
G
G
G
Q
Y
G
E
V
Y
E
-------------------
G
V
W
K
K
Y
S
-
L
T
V
A
V
K
T
L
K
E
D
T
M
E
--
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
-
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
-------------------
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
-----
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
-
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
-
P
Y
P
G
I
D
L
-
S
Q
V
Y
E
L
L
E
K
D
Y
R
-------
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
-
I
H
Q
A
F
E
T
M
F
Q
E
S
S
40
PsiBlast_CBE
65.42
36%
-120
- C1 -
2HIW
1
ABL1_HUMAN
B:
[1-266]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
A
M
D
P
N
Y
--
D
K
W
E
---
M
E
R
T
D
I
T
M
K
H
-
K
L
G
G
G
Q
Y
G
E
V
Y
E
-------------------
G
V
W
K
K
Y
S
-
L
T
V
A
V
K
T
L
K
E
D
T
M
E
--
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
-
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
-------------------
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
-----
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
-
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
-
P
Y
P
G
I
D
L
-
S
Q
V
Y
E
L
L
E
K
D
Y
R
-------
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
-
I
H
Q
A
F
E
T
M
F
Q
E
--
53
PsiBlast_CBE
65.38
37%
-118
- C1 -
1FPU
1
ABL1_MOUSE
B:
[3-269]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
D
P
S
S
--
P
N
Y
D
KWE
M
E
R
T
D
I
T
M
K
H
-
K
L
G
G
G
Q
Y
G
E
V
Y
E
-------------------
G
V
W
K
K
Y
S
-
L
T
V
A
V
K
T
L
K
E
D
T
M
E
--
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
-
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
------------------
R
E
C
N
R
Q
E
-
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
-----
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-------
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
-
P
Y
P
G
I
D
L
-
S
Q
V
Y
E
L
L
E
K
D
Y
R
-------
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
-
I
H
Q
A
F
E
T
M
F
Q
E
--
77
PsiBlast_CBE
65.32
37%
-122
- C1 -
2HYY
1
ABL1_HUMAN
C:
[9-264]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
---
M
E
R
T
D
I
T
M
K
H
-
K
L
G
G
G
Q
Y
G
E
V
Y
E
-------------------
G
V
W
K
K
Y
S
-
L
T
V
A
V
K
T
L
K
E
-
T
M
E
--
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
-
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
-------------------
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
-----
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
----
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
-
P
Y
P
G
I
D
L
-
S
Q
V
Y
E
L
L
E
K
D
Y
R
-------
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
-
I
H
Q
A
F
E
T
M
F
Q
---
103
PsiBlast_CBE
65.28
37%
-124
- C1 -
3CS9
1
ABL1_HUMAN
A:
[13-268]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
---
M
E
R
T
D
I
T
M
K
H
-
K
L
G
G
G
Q
Y
G
E
V
Y
E
-------------------
G
V
W
K
K
Y
S
-
L
T
V
A
V
K
T
L
K
E
------
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
-
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
-------------------
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
-----
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
-
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
-
P
Y
P
G
I
D
L
-
S
Q
V
Y
E
L
L
E
K
D
Y
R
-------
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
-
I
H
Q
A
F
E
T
M
F
Q
E
S
-
37
PsiBlast_CBE
65.27
37%
-127
- C1 -
3PYY
1
ABL1_HUMAN
A:
[18-277]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
D
KWE
M
E
R
T
D
I
T
M
K
H
-
K
L
G
G
G
Q
Y
G
E
V
Y
E
-------------------
G
V
W
K
K
Y
S
-
L
T
V
A
V
K
T
L
K
E
------
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
-
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
-------------------
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
-----
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
-
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
-
P
Y
P
G
I
D
L
-
S
Q
V
Y
E
L
L
E
K
D
Y
R
-------
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
-
I
H
Q
A
F
E
T
M
F
Q
E
S
-
124
HHSearch
65.19
33%
-118
- C1 -
1T46
1
?
A:
[18-305]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
---
F
P
R
N
R
L
S
F
G
K
-
T
L
G
A
G
A
F
G
K
V
V
E
A
T
A
Y
G
---
L
-----------
I
K
S
D
A
A
-
M
T
V
A
V
K
M
L
K
P
S
A
H
L
T
E
R
E
A
L
M
S
E
L
K
V
L
S
Y
L
G
N
H
-
M
N
I
V
N
L
L
G
A
C
T
I
G
-
G
P
T
L
V
I
T
E
Y
C
C
Y
G
D
L
L
N
F
L
R
R
K
R
D
S
F
----------------
L
A
-
L
D
L
E
D
L
L
S
F
S
Y
Q
V
A
K
G
M
A
F
L
A
S
K
N
C
I
H
R
D
L
A
A
R
N
I
L
L
T
-----
H
G
R
I
T
K
I
C
D
F
G
L
A
R
D
I
K
N
D
S
-
N
Y
V
V
K
G
N
A
R
L
P
V
K
W
M
A
P
E
S
I
F
N
C
V
Y
T
F
E
S
D
V
W
S
Y
G
I
F
L
W
E
L
F
S
L
-
G
S
S
P
Y
P
G
M
P
V
-
D
S
K
F
Y
K
M
---
I
K
E
-
G
--
F
R
M
L
S
P
E
H
A
P
A
E
M
Y
D
I
M
K
T
C
W
D
A
D
P
L
K
R
P
T
F
K
Q
-
I
V
Q
L
I
E
K
Q
I
S
E
S
T
51
PsiBlast_CBE
65.18
37%
-116
- C1 -
1IEP
1
ABL1_MOUSE
B:
[3-269]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
D
P
S
S
--
P
N
Y
D
KWE
M
E
R
T
D
I
T
M
K
H
-
K
L
G
G
G
Q
Y
G
E
V
Y
E
-------------------
G
V
W
K
K
Y
S
-
L
T
V
A
V
K
T
L
K
E
D
T
M
E
--
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
-
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
------------------
R
E
C
N
R
Q
E
-
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
-----
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
-
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
-
P
Y
P
G
I
D
L
-
S
Q
V
Y
E
L
L
E
K
D
Y
R
-------
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
-
I
H
Q
A
F
E
T
M
F
Q
---
123
HHSearch
64.89
38%
-127
- C1 -
3ZBF
1
A:
[24-306]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
E
--
N
L
P
A
---
F
P
R
E
K
L
T
L
R
L
-
L
L
G
S
---
G
E
V
Y
E
G
T
A
V
D
---
I
L
---------
G
V
-
G
S
G
E
-
I
K
V
A
V
K
T
L
K
K
G
S
T
D
Q
E
K
I
E
F
L
K
E
A
H
L
M
S
K
F
-
N
H
-
P
N
I
L
K
Q
L
G
V
C
L
L
N
-
E
P
Q
Y
I
I
L
E
L
M
E
G
G
D
L
L
T
Y
L
R
K
A
R
M
A
T
-------------
F
Y
G
P
L
-
L
T
L
V
D
L
V
D
L
C
V
D
I
S
K
G
C
V
Y
L
E
R
M
H
F
I
H
R
D
L
A
A
R
N
C
L
V
S
VKDYT
S
P
R
I
V
K
I
G
D
F
G
L
A
R
D
I
Y
-------------
L
P
V
R
W
M
A
P
E
S
L
M
D
G
I
F
T
T
Q
S
D
V
W
S
F
G
I
L
I
W
E
I
L
T
L
-
G
H
Q
P
Y
P
A
H
S
N
-
L
D
V
L
N
Y
V
----
Q
T
G
G
---
R
L
E
P
P
R
N
C
P
D
D
L
W
N
L
M
T
Q
C
W
A
Q
E
P
D
Q
R
P
T
F
H
R
-
I
Q
D
Q
L
Q
L
F
R
N
F
F
L
95
PsiBlast_CBE
64.87
37%
-123
- C1 -
2G2F
1
ABL1_HUMAN
B:
[11-266]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
---
M
E
R
T
D
I
T
M
K
H
-
K
L
G
-----
E
V
Y
E
-------------------
G
V
W
K
K
Y
S
-
L
T
V
A
V
K
T
L
K
E
D
T
M
E
--
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
-
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
-------------------
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
-----
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
-
T
Y
T
A
P
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
-
P
Y
P
G
I
D
L
-
S
Q
V
Y
E
L
L
E
K
D
Y
R
-------
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
-
I
H
Q
A
F
E
T
M
F
Q
E
S
S
92
PsiBlast_CBE
64.73
37%
-123
- C1 -
2G2I
1
ABL1_HUMAN
A:
[11-266]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
---
M
E
R
T
D
I
T
M
K
H
-
K
L
G
G
G
---
E
V
Y
E
-------------------
G
V
W
K
K
Y
S
-
L
T
V
A
V
K
T
L
K
E
D
T
M
E
--
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
-
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
-------------------
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
-----
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
-
T
Y
T
A
P
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
-
P
Y
P
G
I
D
L
-
S
Q
V
Y
E
L
L
E
K
D
Y
R
-------
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
-
I
H
Q
A
F
E
T
M
F
Q
E
S
S
63
PsiBlast_CBE
64.67
37%
-121
- C1 -
2G1T
1
ABL1_HUMAN
C:
[11-266]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
---
M
E
R
T
D
I
T
M
K
H
-
K
L
G
G
G
Q
Y
G
E
V
Y
E
-------------------
G
V
W
K
K
Y
S
-
L
T
V
A
V
K
T
L
K
E
D
T
M
E
--
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
-
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
-------------------
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
-----
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
-
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
-
P
Y
P
G
I
D
L
-
S
Q
V
Y
E
L
L
E
K
D
Y
R
-------
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
-
I
H
Q
A
F
E
T
M
F
Q
E
S
S
68
PsiBlast_CBE
64.63
37%
-126
- C1 -
4WA9
1
ABL1_HUMAN
B:
[10-265]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
---
M
E
R
T
D
I
T
M
K
H
-
K
L
G
G
G
Q
Y
G
E
V
Y
E
-------------------
G
V
W
K
K
Y
S
-
L
T
V
A
V
K
T
L
K
E
D
T
M
E
--
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
-
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
-------------------
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
-----
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
-
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
-
P
Y
P
G
I
D
L
-
S
Q
V
Y
E
L
L
E
K
D
Y
R
-------
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
-
I
H
Q
A
F
E
T
M
F
Q
E
S
S
76
PsiBlast_CBE
64.60
37%
-122
- C1 -
2HYY
1
ABL1_HUMAN
D:
[9-264]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
---
M
E
R
T
D
I
T
M
K
H
-
K
L
G
G
G
Q
Y
G
E
V
Y
E
-------------------
G
V
W
K
K
Y
S
-
L
T
V
A
V
K
T
L
K
E
--
M
E
--
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
-
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
-------------------
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
-----
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
-
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
-
P
Y
P
G
I
D
L
-
S
Q
V
Y
E
L
L
E
K
D
Y
R
-------
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
-
I
H
Q
A
F
E
T
M
F
Q
---
43
PsiBlast_CBE
64.59
37%
-123
- C1 -
3MS9
2
ABL1_MOUSE
A:
[2-269]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
M
D
P
----
P
N
Y
D
KWE
M
E
R
T
D
I
T
M
K
H
-
K
L
G
G
G
Q
Y
G
E
V
Y
E
-------------------
G
V
W
K
K
Y
S
-
L
T
V
A
V
K
T
L
--------
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
-
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
------------------
R
E
C
N
R
Q
E
-
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
-----
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
--
G
D
-
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
-
P
Y
P
G
I
D
L
-
S
Q
V
Y
E
L
L
E
K
D
Y
R
-------
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
-
I
H
Q
A
F
E
T
M
F
Q
---
84
PsiBlast_CBE
64.54
37%
-121
- C1 -
3OY3
1
ABL1_MOUSE
A:
[1-264]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
S
--
P
N
Y
D
KWE
M
E
R
T
D
I
T
M
K
H
-
K
L
G
G
G
Q
Y
G
E
V
Y
E
-------------------
G
V
W
K
K
Y
S
-
L
T
V
A
V
K
T
L
K
E
D
T
M
E
--
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
-
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
-------------------
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
-----
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
-
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
-
P
Y
P
G
I
D
L
-
S
Q
V
Y
E
L
L
E
K
D
Y
R
-------
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
-
I
H
Q
A
F
E
T
M
F
Q
E
S
S
79
PsiBlast_CBE
64.43
37%
-117
- C1 -
2HYY
1
ABL1_HUMAN
A:
[9-264]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
---
M
E
R
T
D
I
T
M
K
H
-
K
L
G
G
G
Q
Y
G
E
V
Y
E
-------------------
G
V
W
K
K
Y
S
-
L
T
V
A
V
K
T
L
K
-
D
T
M
E
--
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
-
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
-------------------
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
-----
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
-
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
-
P
Y
P
G
I
D
L
-
S
Q
V
Y
E
L
L
E
K
D
Y
R
-------
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
-
I
H
Q
A
F
E
T
M
F
Q
---
75
PsiBlast_CBE
64.35
37%
-113
- C1 -
2HZ0
1
ABL1_HUMAN
A:
[9-264]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
---
M
E
R
T
D
I
T
M
K
H
-
K
L
G
G
G
Q
Y
G
E
V
Y
E
-------------------
G
V
W
K
K
Y
S
-
L
T
V
A
V
K
T
L
K
E
D
T
M
E
--
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
-
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
-------------------
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
-----
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
-
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
-
P
Y
P
G
I
D
L
-
S
Q
V
Y
E
L
L
E
K
D
Y
R
-------
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
-
I
H
Q
A
F
E
T
M
F
----
61
PsiBlast_CBE
64.23
37%
-123
- C1 -
3UE4
1
ABL1_HUMAN
A:
[11-266]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
---
M
E
R
T
D
I
T
M
K
H
-
K
L
G
G
G
Q
Y
G
E
V
Y
E
-------------------
G
V
W
K
K
Y
S
-
L
T
V
A
V
K
T
L
K
E
D
T
M
E
--
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
-
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
-------------------
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
-----
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
-
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
-
P
Y
P
G
I
D
L
-
S
Q
V
Y
E
L
L
E
K
D
Y
R
-------
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
-
I
H
Q
A
F
E
T
M
F
Q
E
S
S
46
PsiBlast_CBE
64.14
37%
-120
- C1 -
2HZN
1
ABL1_MOUSE
A:
[3-269]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
D
P
S
S
--
P
N
Y
D
KWE
M
E
R
T
D
I
T
M
K
H
-
K
L
G
G
G
---
E
V
Y
E
-------------------
G
V
W
K
K
Y
S
-
L
T
V
A
V
K
T
L
--
D
T
M
E
--
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
-
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
------------------
R
E
C
N
R
Q
E
-
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
-----
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
-
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
-
P
Y
P
G
I
D
L
-
S
Q
V
Y
E
L
L
E
K
D
Y
R
-------
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
-
I
H
Q
A
F
E
T
M
F
Q
E
S
S
134
HHSearch
63.99
35%
-120
- C1 -
1U59
1
A:
[5-271]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
---
L
K
R
D
N
L
L
I
A
D
I
E
L
G
C
G
N
F
G
S
V
R
Q
G
V
Y
R
--------------------
K
Q
-
I
D
V
A
I
K
V
L
K
Q
G
T
E
K
A
D
T
E
E
M
M
R
E
A
Q
I
M
H
Q
L
-
D
N
-
P
Y
I
V
R
L
I
G
V
C
Q
A
--
E
A
L
M
L
V
M
E
M
A
G
G
G
P
L
H
K
F
L
V
G
K
R
-------------------
E
E
-
I
P
V
S
N
V
A
E
L
L
H
Q
V
S
M
G
M
K
Y
L
E
E
K
N
F
V
H
R
D
L
A
A
R
N
V
L
L
V
-----
N
R
H
Y
A
K
I
S
D
F
G
L
S
K
A
L
G
A
D
D
S
Y
Y
T
A
R
S
A
G
K
W
P
L
K
W
Y
A
P
E
C
I
N
F
R
K
F
S
S
R
S
D
V
W
S
Y
G
V
T
M
W
E
A
L
S
Y
-
G
Q
K
P
Y
K
K
M
K
G
-
P
E
V
M
A
F
I
-----
E
Q
G
K
--
R
M
E
C
P
P
E
C
P
P
E
L
Y
A
L
M
S
D
C
W
I
Y
K
W
E
D
R
P
D
F
L
T
-
V
E
Q
R
M
R
A
C
Y
Y
S
L
A
78
PsiBlast_CBE
63.71
37%
-119
- C1 -
2HYY
1
ABL1_HUMAN
B:
[9-264]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
---
M
E
R
T
D
I
T
M
K
H
-
K
L
G
G
G
Q
Y
G
E
V
Y
E
-------------------
G
V
W
K
K
Y
S
-
L
T
V
A
V
K
T
L
K
E
-
T
M
E
--
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
-
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
-------------------
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
-----
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
-
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
-
P
Y
P
G
I
D
L
-
S
Q
V
Y
E
L
L
E
K
D
Y
R
-------
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
-
I
H
Q
A
F
E
T
M
F
Q
---
74
PsiBlast_CBE
63.21
37%
-129
- C1 -
2HZ0
1
ABL1_HUMAN
B:
[9-264]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
---
M
E
R
T
D
I
T
M
K
H
-
K
L
------
E
V
Y
E
-------------------
G
V
W
K
K
Y
S
-
L
T
V
A
V
K
T
L
----
M
E
--
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
-
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
-------------------
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
-----
E
N
H
L
V
K
V
A
D
F
G
L
-------------------
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
-
P
Y
P
G
I
D
L
-
S
Q
V
Y
E
L
L
E
K
D
Y
R
-------
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
-
I
H
Q
A
F
E
T
M
F
----
91
PsiBlast_CBE
62.85
37%
-127
- C1 -
2G2I
1
ABL1_HUMAN
B:
[11-266]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
---
M
E
R
T
D
I
T
M
K
H
-
K
L
G
G
----
E
V
Y
E
-------------------
G
V
W
K
K
Y
S
-
L
T
V
A
V
K
T
L
K
E
D
T
M
E
--
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
-
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
-------------------
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
-----
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
-
T
Y
T
A
P
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
-
P
Y
P
G
I
D
L
-
S
Q
V
Y
E
L
L
E
K
D
Y
R
-------
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
-
I
H
Q
A
F
E
T
M
F
Q
E
S
-
69
PsiBlast_CBE
62.26
37%
-119
- C1 -
4WA9
1
ABL1_HUMAN
A:
[10-265]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
---
M
E
R
T
D
I
T
M
K
H
-
K
L
G
G
G
Q
Y
G
E
V
Y
E
-------------------
G
V
W
K
K
Y
S
-
L
T
V
A
V
K
----------------------
E
I
-
K
H
-
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
---
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
-------------------
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
-----
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
-
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
-
P
Y
P
G
I
D
L
-
S
Q
V
Y
E
L
L
E
K
D
Y
R
-------
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
-
I
H
Q
A
F
E
T
M
F
Q
E
S
S
26
PsiBlast_CBE
62.26
38%
-122
- C1 -
4CSV
1
?
A:
[7-262]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
---
I
P
R
S
E
I
T
L
E
R
-
K
L
G
S
G
Q
F
G
E
V
Y
E
G
K
-------------------
W
R
N
Y
N
-
I
E
V
A
V
K
T
L
K
E
G
T
M
--
S
V
E
E
F
L
Q
E
A
Q
I
M
K
K
L
-
K
H
-
P
N
L
V
Q
L
Y
G
V
C
T
K
E
-
P
P
I
Y
I
I
T
E
Y
M
S
H
G
S
L
L
D
Y
L
------------------
R
D
C
-----
V
N
A
Q
A
L
L
D
M
A
A
Q
V
A
S
G
M
A
Y
L
E
S
Q
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
-----
E
N
N
V
V
K
V
A
D
F
G
-------------------
F
P
I
K
W
T
A
P
E
A
I
S
Y
N
R
F
S
I
K
S
D
V
W
A
F
G
I
L
L
W
E
I
F
T
Y
G
Q
V
-
P
Y
P
G
M
S
G
-
S
E
V
I
E
Q
V
E
R
G
Y
R
-------
M
P
R
P
Q
G
C
P
E
E
I
Y
E
L
M
L
Q
C
W
N
K
S
P
E
E
R
P
T
F
A
E
T
L
H
A
L
E
T
M
F
L
----
25
PsiBlast_CBE
60.48
38%
-122
- C1 -
4UEU
1
?
A:
[7-262]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
---
I
P
R
S
E
I
T
L
E
R
-
K
L
G
S
G
Q
F
G
E
V
Y
E
G
K
-------------------
W
R
N
Y
N
-
I
E
V
A
V
K
T
L
K
E
G
T
M
--
S
V
E
E
F
L
Q
E
A
Q
I
M
K
K
L
-
K
H
-
P
N
L
V
Q
L
Y
G
V
C
T
K
E
-
P
P
I
Y
I
I
T
E
Y
M
S
H
G
S
L
L
D
Y
L
------------------
R
D
C
E
G
H
T
-
V
N
A
Q
A
L
L
D
M
A
A
Q
V
A
S
G
M
A
Y
L
E
S
Q
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
-----
E
N
N
V
V
K
V
A
D
F
G
L
A
R
-
L
I
-----------
A
K
F
P
I
K
W
T
A
P
E
A
I
S
Y
N
R
F
S
I
K
S
D
V
W
A
F
G
I
L
L
W
E
I
F
T
Y
G
Q
V
-
P
Y
P
G
M
S
G
-
S
E
V
I
E
Q
V
E
R
G
Y
R
-------
M
P
R
P
Q
G
C
P
E
E
I
Y
E
L
M
L
Q
C
W
N
K
S
P
E
E
R
P
T
F
A
E
T
L
H
A
L
E
T
M
F
-----
10
PsiBlast_PDB
58.52
45%
-90
- C1 -
4YMJ
4
NTRK3_HUMAN
A:
[6-289]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
I
--
H
V
Q
H
---
I
K
R
R
D
I
V
L
K
R
-
E
L
G
E
G
A
F
G
K
V
F
L
A
E
C
-------------
Y
N
L
S
P
T
K
D
-
K
-
M
L
V
A
V
K
A
L
K
-
D
P
T
L
A
A
R
K
D
F
Q
R
E
A
E
L
L
T
N
L
-
Q
H
-
E
H
I
V
K
F
Y
G
V
C
G
D
G
-
D
P
L
I
M
V
F
E
Y
M
K
H
G
D
L
N
K
F
L
R
A
H
G
P
-----------------
G
E
--
L
G
L
S
Q
M
L
H
I
A
S
Q
I
A
S
G
M
V
Y
L
A
S
Q
H
F
V
H
R
D
L
A
T
R
N
C
L
V
G
-----
A
N
L
L
V
K
I
G
D
F
G
---
D
V
Y
S
T
D
-
Y
Y
R
---
H
T
M
L
P
I
R
W
M
P
P
E
S
I
M
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
I
L
W
E
I
F
T
Y
G
K
-
Q
P
W
F
Q
L
S
N
-
T
E
V
I
E
C
I
-----
T
Q
G
R
--
V
L
E
R
P
R
V
C
P
K
E
V
Y
D
V
M
L
G
C
W
Q
R
E
P
Q
Q
R
L
N
I
K
E
-
I
Y
K
I
L
H
A
L
G
K
A
T
-