@TOME V2.3
(Nov 2016)

Ref. - - Doc.
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Alignment:

3D Common Core:

Structural Clustering:

Modeller Result :

Complexes Modeling
Templates Information:
Sequence & Result Tab:

Values color: [ Good | Correct | Middling | Bad ]Sequence color : MutatedHelixStrandConserved

Query sequence : DDR2_HUMAN: (2015-10-06 )
MILIPRMLLVLFLLLPILSSAKAQVNPAICRYPLGMSGGQIPDEDITASSQWSESTAAKYGRLDSEEGDGAWCPEIPVEPDDLKEFLQIDLHTLHFITLVGTQGRHAGGHGIEFAPMYKINYSRDGTRWISWRNRHGKQVLDGNSNPYDIFLKDLEPPIVARFVRFIPVTDHSMNVCMRVELYGCVWLDGLVSYNAPAGQQFVLPGGSIIYLNDSVYDGAVGYSMTEGLGQLTDGVSGLDDFTQTHEYHVWPGYDYVGWRNESATNGYIEIMFEFDRIRNFTTMKVHCNNMFAKGVKIFKEVQCYFRSEASEWEPNAISFPLVLDDVNPSARFVTVPLHHRMASAIKCQYHFADTWMMFSEITFQSDAAMYNNSEALPTSPMAPTTYDPMLKVDDSNTRILIGCLVAIIFILLAIIVIILWRQFWQKMLEKASRRMLDDEMTVSLSLPSDSSMFNNNRSSSPSEQGSNSTYDRIFPLRPDYQEPSRLIRKLPEFAPGEEESGCSGVVKPVQPSGPEGVPHYAEADIVNLQGVTGGNTYSVPAVTMDLLSGKDVAVEEFPRKLLTFKEKLGEGQFGEVHLCEVEGMEKFKDKDFALDVSANQPVLVAVKMLRADANKNARNDFLKEIKIMSRLKDPNIIHLLAVCITDDPLCMITEYMENGDLNQFLSRHEPPNSSSSDVRTVSYTNLKFMATQIASGMKYLSSLNFVHRDLATRNCLVGKNYTIKIADFGMSRNLYSGDYYRIQGRAVLPIRWMSWESILLGKFTTASDVWAFGVTLWETFTFCQEQPYSQLSDEQVIENTGEFFRDQGRQTYLPQPAICPDSVYKLMLSCWRRDTKNRPSFQEIHLLLLQQGDE

Atome Classification :

(104 SA) .........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550....---...560.......570.......580.......590.......600.......610.......620.......630-.-......640.....-..650.......660.......670--.----..---...------.-..680-........690.......700.......710.......-----720.......730.......740.......750.......760.......770.......780.......790..-.....800.......810.......820.......830.......840..-.....850...
(Atome) (Ident) (Tito) (Num) (Ligand) (Uniprot) MILIPRMLLVLFLLLPILSSAKAQVNPAICRYPLGMSGGQIPDEDITASSQWSESTAAKYGRLDSEEGDGAWCPEIPVEPDDLKEFLQIDLHTLHFITLVGTQGRHAGGHGIEFAPMYKINYSRDGTRWISWRNRHGKQVLDGNSNPYDIFLKDLEPPIVARFVRFIPVTDHSMNVCMRVELYGCVWLDGLVSYNAPAGQQFVLPGGSIIYLNDSVYDGAVGYSMTEGLGQLTDGVSGLDDFTQTHEYHVWPGYDYVGWRNESATNGYIEIMFEFDRIRNFTTMKVHCNNMFAKGVKIFKEVQCYFRSEASEWEPNAISFPLVLDDVNPSARFVTVPLHHRMASAIKCQYHFADTWMMFSEITFQSDAAMYNNSEALPTSPMAPTTYDPMLKVDDSNTRILIGCLVAIIFILLAIIVIILWRQFWQKMLEKASRRMLDDEMTVSLSLPSDSSMFNNNRSSSPSEQGSNSTYDRIFPLRPDYQEPSRLIRKLPEFAPGEEESGCSGVVKPVQPSGPEGVPHYAEADIVNLQGVTGGNTYSVPAVTMDLLSGKDVAVE---EFPRKLLTFKEKLGEGQFGEVHLCEVEGMEKFKDKDFALDVSANQPVLVAVKMLRADANKNARNDFLKEIKIMSRL-K-DPNIIHLLAVCITD-DPLCMITEYMENGDLNQFLSRHE----P----PN---SSS------S-DVRT--VSYTNLKFMATQIASGMKYLSSLNFVHRDLATRNCLVG-----KNYTIKIADFGMSRNLYSGDYYRIQGRAVLPIRWMSWESILLGKFTTASDVWAFGVTLWETFTFCQEQPYSQLSD-EQVIENTGEFFRDQGRQTYLPQPAICPDSVYKLMLSCWRRDTKNRPSFQE-IHLLLLQQGDE
116 HHSearch 97.5268%-111 - C2 -4BKJ DDR1_HUMAN A:[5-311] ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------V---DFPRSRLRFKEKLGEGQFGEVHLCEVDSPQDLVSLDFPLNVRKGHPLLVAVKILRPDATKNARNDFLKEVKIMSRL-K-DPNIIRLLGVCVQD-DPLCMITDYMENGDLNQFLSAHQ----L----ED----------------PT--ISYPMLLHVAAQIASGMRYLATLNFVHRDLATRNCLVG-----ENFTIKIADFGMSRNLYAGDYY----RAVLPIRWMAWECILMGKFTTASDVWAFGVTLWEVLMLCRAQPFGQLTD-EQVIENAGEFFRDQGRQVYLSRPPACPQGLYELMLRCWSRESEQRPPFSQ-LHRFLAEDALN
5 PsiBlast_PDB 96.9067%-116 - C2 -4BKJ DDR1_HUMAN A:[6-309] -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DFPRSRLRFKEKLGEGQFGEVHLCEVDSPQDLVSLDFPLNVRKGHPLLVAVKILRPDATKNARNDFLKEVKIMSRL-K-DPNIIRLLGVCVQD-DPLCMITDYMENGDLNQFLSAHQLED------------------------PT--ISYPMLLHVAAQIASGMRYLATLNFVHRDLATRNCLVG-----ENFTIKIADFGMSRNLYAGDYY----RAVLPIRWMAWECILMGKFTTASDVWAFGVTLWEVLMLCRAQPFGQLTD-EQVIENAGEFFRDQGRQVYLSRPPACPQGLYELMLRCWSRESEQRPPFSQ-LHRFLAEDALN
22 PsiBlast_CBE 96.0067%-117 - C2 -3ZOS B:[6-309] -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DFPRSRLRFKEKLGEGQFGEVHLCEVDSPQDLVSLDFPLNVRKGHPLLVAVKILRPDATKNARNDFLKEVKIMSRL-K-DPNIIRLLGVCVQD-DPLCMITDYMENGDLNQFLSAHQLEDK---------------------QGPT--ISYPMLLHVAAQIASGMRYLATLNFVHRDLATRNCLVG-----ENFTIKIADFGMSRNLYAGDYYRVQGRAVLPIRWMAWECILMGKFTTASDVWAFGVTLWEVLMLCRAQPFGQLTD-EQVIENAGEFFRDQGRQVYLSRPPACPQGLYELMLRCWSRESEQRPPFSQ-LHRFLAEDALN
21 PsiBlast_CBE 95.3067%-115 - C2 -4BKJ B:[6-309] -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DFPRSRLRFKEKLGEGQFGEVHLCEVDSPQDLVSLDFPLNVRKGHPLLVAVKILRPDATKNARNDFLKEVKIMSRL-K-DPNIIRLLGVCVQD-DPLCMITDYMENGDLNQFLSAHQLEDK----------------------GPT--ISYPMLLHVAAQIASGMRYLATLNFVHRDLATRNCLVG-----ENFTIKIADFGMSRNLYAGDYY----RAVLPIRWMAWECILMGKFTTASDVWAFGVTLWEVLMLCRAQPFGQLTD-EQVIENAGEFFRDQGRQVYLSRPPACPQGLYELMLRCWSRESEQRPPFSQ-LHRFLAEDALN
4 PsiBlast_PDB 94.3467%-117 - C2 -3ZOS DDR1_HUMAN A:[6-309] -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DFPRSRLRFKEKLGEGQFGEVHLCEVDSPQDLVSLDFPLNVRKGHPLLVAVKILRPDATKNARNDFLKEVKIMSRL-K-DPNIIRLLGVCVQD-DPLCMITDYMENGDLNQFLSAHQLED-------------A------A-QGPT--ISYPMLLHVAAQIASGMRYLATLNFVHRDLATRNCLVG-----ENFTIKIADFGMSRNLYAGDYYRVQGRAVLPIRWMAWECILMGKFTTASDVWAFGVTLWEVLMLCRAQPFGQLTD-EQVIENAGEFFRDQGRQVYLSRPPACPQGLYELMLRCWSRESEQRPPFSQ-LHRFLAEDALN
2 PsiBlast_PDB 92.8867%-121 - C2 -5BVW ? A:[15-318] -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DFPRSRLRFKEKLGEGQFGEVHLCEVDS----------------HPLLVAVKILRPDATKNARNDFLKEVKIMSRL-K-DPNIIRLLGVCVQD-DPLCMITDYMENGDLNQFLSAHQLEDK-----------------------PT--ISYPMLLHVAAQIASGMRYLATLNFVHRDLATRNCLVG-----ENFTIKIADFG----LYAGDYYRVQGRAVLPIRWMAWECILMGKFTTASDVWAFGVTLWEVLMLCRAQPFGQLTD-EQVIENAGEFFRDQGRQVYLSRPPACPQGLYELMLRCWSRESEQRPPFSQ-LHRFLAEDALN
3 PsiBlast_PDB 92.4467%-117 - C2 -5BVN ? A:[15-318] -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DFPRSRLRFKEKLGEGQFGEVHLCEVDS----------------HPLLVAVKILRPDATKNARNDFLKEVKIMSRL-K-DPNIIRLLGVCVQD-DPLCMITDYMENGDLNQFLSAHQLEDK-----------------------PT--ISYPMLLHVAAQIASGMRYLATLNFVHRDLATRNCLVG-----ENFTIKIADFGMSRNLYAGDYYRVQGRAVLPIRWMAWECILMGKFTTASDVWAFGVTLWEVLMLCRAQPFGQLTD-EQVIENAGEFFRDQGRQVYLSRPPACPQGLYELMLRCWSRESEQRPPFSQ-LHRFLAEDALN
1 PsiBlast_PDB 92.0367%-114 - C2 -5BVK ? A:[15-318] -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DFPRSRLRFKEKLGEGQFGEVHLCEVDS----------------HPLLVAVKILRPDATKNARNDFLKEVKIMSRL-K-DPNIIRLLGVCVQD-DPLCMITDYMENGDLNQFLSAHQLEDK-----------------------PT--ISYPMLLHVAAQIASGMRYLATLNFVHRDLATRNCLVG-----ENFTIKIADFGMSRNLYAGDYYRVQGRAVLPIRWMAWECILMGKFTTASDVWAFGVTLWEVLMLCRAQPFGQLTD-EQVIENAGEFFRDQGRQVYLSRPPACPQGLYELMLRCWSRESEQRPPFSQ-LHRFLAEDALN
120 HHSearch 80.7846%-110 * C2 *4AOJ NTRK1_HUMAN A:[34-318] -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------CVH---HIKRRDIVLKWELGEGAFGKVFLAECHNL-----------LP---KMLVAVKALKE-ASESARQDFQREAELLTML-Q-HQHIVRFFGVCTEG-RPLLMVFEYMRHGDLNRFLRSHG----P----D----------------PGP--LGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVG-----QGLVVKIGDFG----------------TMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTY-GKQPWYQLSN-TEAIDCIT-----QGR--ELERPRACPPEVYAIMRGCWQREPQQRHSIKD-VHARLQALAQA
23 PsiBlast_CBE 80.1144%-109 - C2 -4AOJ C:[33-314] ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ACVH---HIKRRDIVLKWELGEGAFGKVFLAECHNLLP-QDK-----------MLVAVKALK-EASESARQDFQREAELLTML-Q-HQHIVRFFGVCTEG-RPLLMVFEYMRHGDLNRFLRSHG----P----D-------------------GPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVG-----QGLVVKIGDFGM----------------MLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTY-GKQPWYQLSN-TEAIDCI-----TQGRE--LERPRACPPEVYAIMRGCWQREPQQRHSIKD-VHARLQALAQA
9 PsiBlast_PDB 80.1146%-104 - C2 -4AT3 A:[4-284] -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DTFVQ---HIKRHNIVLKRELGEGAFGKVFLAECYNLC----K-----------ILVAVKTL---ASDNARKDFHREAELLTNL-Q-HEHIVKFYGVCVEG-DPLIMVFEYMKHGDLNKFLRAHG----P----DAVLMA--------N-PPTE--LTQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVG-----ENLLVKIGDFGMSR--YSTDYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSLGVVLWEIFTY-GKQPWYQLSN-NEVIECI-----TQGR--VLQRPRTCPQEVYELMLGCWQREPHMRKNIKG-IHTLLQNLAKA
15 PsiBlast_PDB 79.7044%-109 - C2 -4AOJ NTRK1_HUMAN A:[33-314] ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ACVH---HIKRRDIVLKWELGEGAFGKVFLAECHNLLP---K-----------MLVAVKALK-EASESARQDFQREAELLTML-Q-HQHIVRFFGVCTEG-RPLLMVFEYMRHGDLNRFLRSHG----P----D------------------PGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVG-----QGLVVKIGDFG----------------TMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTY-GKQPWYQLSN-TEAIDCI-----TQGRE--LERPRACPPEVYAIMRGCWQREPQQRHSIKD-VHARLQALAQA
24 PsiBlast_CBE 79.3544%-108 - C2 -4AOJ NTRK1_HUMAN B:[33-314] ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ACVH---HIKRRDIVLKWELGEGAFGKVFLAECHNLLP---K-----------MLVAVKALK-EASESARQDFQREAELLTML-Q-HQHIVRFFGVCTEG-RPLLMVFEYMRHGDLNRFLRSHG----P----D-------------------GPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVG-----QGLVVKIGDF-------------------LPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTY-GKQPWYQLSN-TEAIDCI-----TQGRE--LERPRACPPEVYAIMRGCWQREPQQRHSIKD-VHARLQALAQA
10 PsiBlast_PDB 78.4146%-107 - C2 -4AT4 A:[4-284] -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DTFVQ---HIKRHNIVLKRELGEGAFGKVFLAECYNLC----K-----------ILVAVKTLK-DASDNARKDFHREAELLTNL-Q-HEHIVKFYGVCVEG-DPLIMVFEYMKHGDLNKFLRAHG----P----DAVLMA----------PPTE--LTQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVG-----ENLLVKIGDFGMSRDVYSTDYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSLGVVLWEIFTY-GKQPWYQLSN-NEVIECI-----TQGR--VLQRPRTCPQEVYELMLGCWQREPHMRKNIKG-IHTLLQNLAKA
11 PsiBlast_PDB 77.8446%-102 - C2 -4AT5 A:[4-284] -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DTFVQ---HIKRHNIVLKRELGEGAFGKVFLAECYNL-----K-----------ILVAVKTLK-DASDNARKDFHREAELLTNL-Q-HEHIVKFYGVCVEG-DPLIMVFEYMKHGDLNKFLRAHG----P----DAVLMAEG------N-PPTE--LTQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVG-----ENLLVKIGDFGMSRDVYSTDYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSLGVVLWEIFTY-GKQPWYQLSN-NEVIECI-----TQGR--VLQRPRTCPQEVYELMLGCWQREPHMRKNIKG-IHTLLQNLAKA
17 PsiBlast_PDB 77.6544%-104 - C2 -4YPS A:[4-288] ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GSGIRVH---HIKRRDIVLKWELGE---GKVFLAECHNLL---DK-----------MLVAVKAL----SESARQDFQREAELLTML-Q-HQHIVRFFGVCTEG-RPLLMVFEYMRHGDLNRFLRSHG----P----DAKLLAGG------E-DVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVG-----QGLVVKIGD--MSRDIYSTDYYRV---TMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGK-QPWYQLSN-TEAIDCI-----TQGRE--LERPRACPPEVYAIMRGCWQREPQQRHSIKD-VHARLQALAQA
13 PsiBlast_PDB 76.8144%-112 - C2 -3V5Q NTRK3_HUMAN A:[7-293] ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IHVQ---HIKRRDIVLKREL------KVFLAECYNLSPTKDK-----------MLVAVKAL---PTLAARKDFQREAELLTNL-Q-HEHIVKFYGVCGDG-DPLIMVFEYMKHGDLNKFLRAHG----P--------------------EL-----GLSQMLHIASQIASGMVYLASQHFVHRDLATRNCLVG-----ANLLVKIGDFGM--DVYSTDYYR----TMLPIRWMPPESIMYRKFTTESDVWSFGVILWEIFTYGK-QPWFQLSN-TEVIECI-----TQGR--VLERPRVCPKEVYDVMLGCWQREPQQRLNIKE-IYKILHALGKA
16 PsiBlast_PDB 75.8044%-102 - C2 -4YNE A:[4-288] ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GSGIRVH---HIKRRDIVLKWELGEGAFGKVFLAECHNLLP--DK-----------MLVAVKALK-E-----RQDFQREAELLTML-Q-HQHIVRFFGVCTEG-RPLLMVFEYMRHGDLNRFLRSHG----P----DAKLLAGG------E-DVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVG-----QGLVVKIGDFGMS-----TDYY----RTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGK-QPWYQLSN-TEAIDCI-----TQGRE--LERPRACPPEVYAIMRGCWQREPQQRHSIKD-VHARLQALAQA
19 PsiBlast_PDB 75.3844%-103 - C2 -4PMT A:[2-281] --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VH---HIKRRDIVLKWELGEGAFGKVFLAECHNL----DK-----------MLVAVKAL----------DFQREAELLTML-Q-HQHIVRFFGVCTEG-RPLLMVFEYMRHGDLNRFLRSHG----P----DAKLLAGG------E-DVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVG-----QGLVVKIGDF--SRDIYSTDYYRV---TMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTY-GKQPWYQLSN-TEAIDCI-----TQGRE--LERPRACPPEVYAIMRGCWQREPQQRHSIKD-VHARLQALAQA
128 HHSearch 72.5138% -99 - C2 -2PVF A:[31-315] -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EFPRDKLTLGKPLGEGAFGQVVMAEAVGIDK---------DKP---VTVAVKMLKDDATEKDLSDLVSEMEMMKMIGK-HKNIINLLGACTQD-GPLYVIVEYASKGNLREYLRARR----P----PG---MEY------SY---Q--MTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVT-----ENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTL-GGSPYPGIPV-EELFKLLKE----G---HRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQ-LVEDLDRILTL
30 PsiBlast_CBE 72.0840% -88 - C2 -3NW6 A:[7-283] ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VYVPDEWEVAREKITMSRELGQGSFGMVY----EGVAKGVVKD-------EPETRVAIKTVNEAASMRERIEFLNEASVMKEF-N-CHHVVRLLGVVSQG-QPTLVIMELMTRGDLKSYLRSLR----P----EM---ENN------P-VLAP--PSLSKMIQMAGEIADGMAYLNANKFVHRDLAARNCMVA-----EDFTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMSPESLKDGVFTTYSDVWSFGVVLWEIATLA-EQPYQGLSN-EQVL----RFVMEGG---LLDKPDNCPDMLFELMRMCWQYNPKMRPSFLE-IISSIKEEMEP
124 HHSearch 71.9435% -89 - C2 -1T46 ? A:[18-306] ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------W---EFPRNRLSFGKTLGAGAFGKVVEATAYGLI-----------KSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGN-HMNIVNLLGACTIG-GPTLVITEYCCYGDLLNFLRRKR----D----SF----------------LA--LDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLT-----HGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSL-GSSPYPGMPV-DSKFYKM---IKE---GFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQ-IVQLIEKQISE
125 HHSearch 71.9238% -94 - C2 -3TT0 FGFR1_HUMAN A:[65-350] -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ELPRDRLVLGKPLGEGAFGQVVLAEAIGLDK---------DKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGK-HKNIINLLGACTQD-GPLYVIVEYASKGNLREYLQARR----P----PG---LEYSYNPSHN-PEEQ--LSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVT-----EDNVMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLG-GSPYPGVPV-EELFKLLKE-----G--HRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQ-LVEDLDRIVAL
31 PsiBlast_CBE 71.8140% -88 - C2 -3NW5 A:[6-283] -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DVYVPDEWEVAREKITMSRELGQGSFGMVY----EGVAKGVVKD-------EPETRVAIKTVNEAASMRERIEFLNEASVMKEF-N-CHHVVRLLGVVSQG-QPTLVIMELMTRGDLKSYLRSLR----P----EM---ENN------P-VLAP--PSLSKMIQMAGEIADGMAYLNANKFVHRDLAARNCMVA-----EDFTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMSPESLKDGVFTTYSDVWSFGVVLWEIATLA-EQPYQGLSN-EQVL----RFVMEGG---LLDKPDNCPDMLFELMRMCWQYNPKMRPSFLE-IISSIKEEMEP
36 PsiBlast_CBE 71.6941% -95 - C2 -3LW0 IGF1R_HUMAN A:[11-280] -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EVAREKITMSRELGQGSFGMVY----EGVAKGVVKD-------EPETRVAIKTVNEAASMRERIEFLNEASVMKEF-N-CHHVVRLLGVVSQG-QPTLVIMELMTRGDLKSYLRSLR----P-----------------------P--PSLSKMIQMAGEIADGMAYLNANKFVHRDLAARNCMVA-----EDFTVKIGDFGMTRDIYETDYYRKG---LLPVRWMSPESLKDGVFTTYSDVWSFGVVLWEIATLA-EQPYQGLSN-EQVL----RFVMEGG---LLDKPDNCPDMLFELMRMCWQYNPKMRPSFLE-IISSIKEEMEP
33 PsiBlast_CBE 71.5941% -94 - C2 -3LW0 D:[11-280] -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EVAREKITMSRELGQGSFGMVY----EGVAKGVVKD-------EPETRVAIKTVNEAASMRERIEFLNEASVMKEF-N-CHHVVRLLGVVSQG-QPTLVIMELMTRGDLKSYLRSLR----P-----------------------P--PSLSKMIQMAGEIADGMAYLNANKFVHRDLAARNCMVA-----EDFTVKIGDFGMTRDIYETDYYRKG---LLPVRWMSPESLKDGVFTTYSDVWSFGVVLWEIATLA-EQPYQGLSN-EQVL----RFVMEGG---LLDKPDNCPDMLFELMRMCWQYNPKMRPSFLE-IISSIKEEMEP
70 PsiBlast_CBE 71.3340% -90 - C2 -3ETA INSR_HUMAN A:[12-285] -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EVSREKITLLRELGQGSFGMVY----EG----NARDI---IKGEAETRVAVKTVNESASLRERIEFLNEASVMKGF-T-CHHVVRLLGVVSKG-QPTLVVMELMAHGDLKSYLRSLR----P----EA---ENN------P-GRPP--PTLQEMIQMAAEIADGMAYLNAKKFVHRDLAARNCMVA-----HDFTVKIGDFGMTRDIYETDYYRKG-KGLLPVRWMAPESLKDGVFTTSSDMWSFGVVLWE-ITSLAEQPYQGLSN-EQVL----KFVMDGG---YLDQPDNCPERVTDLMRMCWQFNPKMRPTFLE-IVNLLKDDLHP
35 PsiBlast_CBE 71.2641% -94 - C2 -3LW0 IGF1R_HUMAN B:[11-280] -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EVAREKITMSRELGQGSFGMVY----EGVAKGVVKD-------EPETRVAIKTVNEAASMRERIEFLNEASVMKEF-N-CHHVVRLLGVVSQG-QPTLVIMELMTRGDLKSYLRSLR----P-----------------------P--PSLSKMIQMAGEIADGMAYLNANKFVHRDLAARNCMVA-----EDFTVKIGDFGMTRDIYETDYYRKG---LLPVRWMSPESLKDGVFTTYSDVWSFGVVLWEIATLA-EQPYQGLSN-EQVL----RFVMEGG---LLDKPDNCPDMLFELMRMCWQYNPKMRPSFLE-IISSIKEEMEP
28 PsiBlast_CBE 71.0140% -90 - C2 -3I81 A:[6-283] -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DVYVPDEWEVAREKITMSRELGQGSFGMVY----EGVAKGVVKD-------EPETRVAIKTVNEAASMRERIEFLNEASVMKEF-N-CHHVVRLLGVVSQG-QPTLVIMELMTRGDLKSYLRSLR----P----E----ENN------P-VLAP--PSLSKMIQMAGEIADGMAYLNANKFVHRDLAARNCMVA-----EDFTVKIGDFGMTRDIYETDYYR-----LLPVRWMSPESLKDGVFTTYSDVWSFGVVLWEIATLA-EQPYQGLSN-EQVL----RFVMEGG---LLDKPDNCPDMLFELMRMCWQYNPKMRPSFLE-IISSIKEEMEP
34 PsiBlast_CBE 70.9141% -95 - C2 -3LW0 IGF1R_HUMAN C:[11-280] -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EVAREKITMSRELGQGSFGMVY----EGVAKGVVKD-------EPETRVAIKTVNEAASMRERIEFLNEASVMKEF-N-CHHVVRLLGVVSQG-QPTLVIMELMTRGDLKSYLRSLR----P-----------------------P--PSLSKMIQMAGEIADGMAYLNANKFVHRDLAARNCMVA-----EDFTVKIGDFGMTRDIYETDYYRKG---LLPVRWMSPESLKDGVFTTYSDVWSFGVVLWEIATLA-EQPYQGLSN-EQVL----RFVMEGG---LLDKPDNCPDMLFELMRMCWQYNPKMRPSFLE-IISSIKEEMEP
40 PsiBlast_CBE 70.8141% -93 - C2 -3QQU IGF1R_HUMAN A:[8-277] -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EVAREKITMSRELGQGSFGMVY----EGVAKGVVKD-------EPETRVAIKTVNEAASMRERIEFLNEASVMKEF-N-CHHVVRLLGVVSQG-QPTLVIMELMTRGDLKSYLRSLR----------------------------P--PSLSKMIQMAGEIADGMAYLNANKFVHRDLAARNCMVA-----EDFTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMSPESLKDGVFTTYSDVWSFGVVLWEIATLA-EQPYQGLSN-EQVL----RFVMEGG---LLDKPDNCPDMLFELMRMCWQYNPKMRPSFLE-IISSIKEEMEP
69 PsiBlast_CBE 70.5140% -89 - C2 -3ETA B:[12-285] -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EVSREKITLLRELGQGSFGMVY----EG----NARDI---IKGEAETRVAVKTVNESASLRERIEFLNEASVMKGF-T-CHHVVRLLGVVSKG-QPTLVVMELMAHGDLKSYLRSLR----P----EA---ENN------P-GRPP--PTLQEMIQMAAEIADGMAYLNAKKFVHRDLAARNCMVA-----HDFTVKIGDFGMTRDIYETDYYRK--KGLLPVRWMAPESLKDGVFTTSSDMWSFGVVLWE-ITSLAEQPYQGLSN-EQVL----KFVMDGG---YLDQPDNCPERVTDLMRMCWQFNPKMRPTFLE-IVNLLKDDLHP
32 PsiBlast_CBE 70.2140% -86 - C2 -2OJ9 A:[5-283] ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ADVYVPDEWEVAREKITMSRELGQGSFGMVY----EGVAKGVVKD-------EPETRVAIKTVNEAASMRERIEFLNEASVMKEF-N-CHHVVRLLGVVSQG-QPTLVIMELMTRGDLKSYLRSLR----P----E------------------P--PSLSKMIQMAGEIADGMAYLNANKFVHRDLAARNCMVA-----EDFTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMSPESLKDGVFTTYSDVWSFGVVLWEIATLA-EQPYQGLSN-EQVL----RFVMEGG---LLDKPDNCPDMLFELMRMCWQYNPKMRPSFLE-IISSIKEEMEP
127 HHSearch 70.2037% -89 - C2 -2I1M A:[41-325] ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------W---EFPRNNLQFGKTLGAGAFGKVVEATAFGLG-----------KEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQ-HENIVNLLGACTHG-GPVLVITEYCCYGDLLNFLRRKS----RVLETD-----------------ST--ASTRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLT-----NGHVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSL-GLNPYPGILV-NSKFYKL---VKD-G--YQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQ-ICSFLQEQAQE
29 PsiBlast_CBE 70.0640% -86 - C2 -3NW7 A:[8-283] -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YVPDEWEVAREKITMSRELGQGSFGMVY----EGVAKGVVKD-------EPETRVAIKTVNEAASMRERIEFLNEASVMKEF-N-CHHVVRLLGVVSQG-QPTLVIMELMTRGDLKSYLRSLR----P----EM---ENN------P-VLAP--PSLSKMIQMAGEIADGMAYLNANKFVHRDLAARNCMVA-----EDFTVKIGDFGMTRDIYETDYYRKG---LLPVRWMSPESLKDGVFTTYSDVWSFGVVLWEIATLA-EQPYQGLSN-EQVL----RFVMEGG---LLDKPDNCPDMLFELMRMCWQYNPKMRPSFLE-IISSIKEEMEP
73 PsiBlast_CBE 70.0541%-103 - C2 -3DK3 ABL1_MOUSE A:[7-261] -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EMERTDITMKHKL