@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : DUSTY_HUMAN: (2015-10-06 )
MEGDGVPWGSEPVSGPGPGGGGMIRELCRGFGRYRRYLGRLRQNLRETQKFFRDIKCSHNHTCLSSLTGGGGAERGPAGDVAETGLQAGQLSCISFPPKEEKYLQQIVDCLPCILILGQDCNVKCQLLNLLLGVQVLPTTKLGSEESCKLRRLRFTYGTQTRVSLALPGQYELVHTLVAHQGNWETIPEEDLEVQENNEDAAHVLAELEVTMHHALLQEVDVVVAPCQGLRPTVDVLGDLVNDFLPVITYALHKDELSERDEQELQEIRKYFSFPVFFFKVPKLGSEIIDSSTRRMESERSPLYRQLIDLGYLSSSHWNCGAPGQDTKAQSMLVEQSEKLRHLSTFSHQVLQTRLVDAAKALNLVHCHCLDIFINQAFDMQRDLQITPKRLEYTRKKENELYESLMNIANRKQEEMKDMIVETLNTMKEELLDDATNMEFKDVIVPENGEPVGTREIKCCIRQIQELIISRLNQAVANKLISSVDYLRESFVGTLERCLQSLEKSQDVSVHITSNYLKQILNAAYHVEVTFHSGSSVTRMLWEQIKQIIQRITWVSPPAITLEWKRKVAQEAIESLSASKLAKSICSQFRTRLNSSHEAFAASLRQLEAGHSGRLEKTEDLWLRVRKDHAPRLARLSLESCSLQDVLLHRKPKLGQELGRGQYGVVYLCDNWGGHFPCALKSVVPPDEKHWNDLALEFHYMRSLPKHERLVDLHGSVIDYNYGGGSSIAVLLIMERLHRDLYTGLKAGLTLETRLQIALDVVEGIRFLHSQGLVHRDIKLKNVLLDKQNRAKITDLGFCKPEAMMSGSIVGTPIHMAPELFTGKYDNSVDVYAFGILFWYICSGSVKLPEAFERCASKDHLWNNVRRGARPERLPVFDEECWQLMEACWDGDPLKRPLLGIVQPMLQGIMNRLCKSNSEQPNRGLDDST
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530..---.....540.......550.......560.......570.-......580.......590.-......600.......610...--....620.......630.......640.......650----------.......660.......------670--.----------------.----.-------.---.-----....680---....--..-.-690.......700.......710.......---------720-----.-------........730...----.-----.-----.----.-740-..---...----------.---.---..750.......760.......770.......780.......790.......800---.-----..-----.--.-....810...-.-...-820.-.--------.-.....830....----...840.-.....---.850....--------...-----------860...-------....870-.....-....880.......890.....----..900-----.........910.......920.......---------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MEGDGVPWGSEPVSGPGPGG
G
G
M
I
R
E
L
C
R
G
F
G
R
Y
R
R
Y
L
G
R
L
R
Q
N
L
R
E
T
Q
K
F
F
R
D
IKCSHN
H
T
C
L
S
SLTGGGGAERGPAG
D
V
A
E
T
GLQAGQ
L
S
C
ISFPP
K
E
E
K
Y
L
Q
Q
I
V
D
C
L
P
C
I
L
I
LGQDC
N
V
K
C
Q
L
L
N
L
L
LG
V
Q
V
L
PTTKLGSEES
C
K
L
R
R
L
R
F
TYGTQ
T
R
V
S
L
ALPG
Q
Y
E
L
V
H
T
L
V
AHQGNWETIPEED
L
E
VQENNE
D
A
A
H
V
L
A
E
L
E
V
T
M
H
H
A
L
L
Q
EVD
V
V
VAPCQGL
R
P
T
V
D
V
L
G
D
L
V
N
D
F
L
P
V
I
T
Y
A
L
H
K
D
E
L
SER
D
E
Q
E
L
Q
E
I
R
K
Y
FSFP
V
F
F
F
KVPKL
G
S
E
I
I
D
S
S
T
R
R
M
E
S
ERS
P
L
Y
R
Q
L
I
D
L
GYLSSSHWNCGAPGQD
T
K
A
Q
S
M
L
V
E
Q
S
E
K
L
R
H
L
S
T
F
S
H
Q
V
L
Q
T
R
L
V
D
A
A
K
A
L
N
L
V
H
C
H
C
L
D
I
F
I
N
Q
A
FDMQRDLQIT
P
K
R
L
E
Y
T
R
K
K
E
N
E
L
Y
E
S
L
M
N
I
A
N
R
K
Q
E
E
M
K
D
M
I
V
E
T
L
N
T
M
K
E
E
L
L
DDATN
M
E
F
K
D
V
I
VPENGEPV
G
T
R
E
I
K
C
C
I
R
Q
I
Q
E
L
I
I
S
R
L
N
Q
A
V
A
N
K
L
I
S
S
V
D
Y
L
R
E
S
F
V
G
T
L
E
R
C
L
Q
S
L
EKSQ
D
V
S
V
H
I
T
S
N
Y
L
K
Q
I
LNA
A
Y
H
V
E
V
T
FHSG---
S
S
V
T
R
M
L
W
E
Q
I
K
Q
I
I
Q
R
ITWVSP
P
A
I
T
L
E
W
K
R
K
V
A
Q
E
A
I
-
E
S
L
S
A
S
K
L
A
K
S
I
C
S
Q
F
R
T
RL-NSS
H
E
A
F
A
A
S
L
R
Q
L
EAGHSGRL--E
K
T
E
D
L
W
L
R
V
RKDHAP
R
L
A
R
L
S
LESC
S
L
Q
D
V
L
L
HRKP----------K
L
G
Q
E
LGRGQ
Y
G
V
V
Y
L
C------D----N----------------W----G-------G---H-----F
P
C
A
L
K
S---VVPP--DE-K-H
W
N
D
L
A
L
E
F
H
Y
M
R
SLP
K
H
E
R
L
V
D
LHG
S
V
I
D
---------
Y
-------N-------YGG
G
S
S
I
A
V
L
L
I
M
E
----
R
-----
L
-----
H
----
R
-
D
---
L
Y
---
T
G
L
----------K---A---GL
T
L
E
T
R
L
Q
I
A
L
D
V
V
E
G
I
R
F
L
H
SQGLVHRD
I
K
L
K
N
VLLDKQNRAKITDLGFC
K
-----
P
-----
E
A
-----M--M-SGSIVGTPIH-M-A
P
E
-LF-T-G--------K-YDNS
V
D
V
Y
A
F
G
I
----
L
F
W
Y
ICS-GSVK
L
---
P
E
A
F
E
R
CA--------S
K
D
-----------
H
L
W
N
N
V
-------
R
RGAR---PERLP-VF
D
E
E
C
W
Q
L
M
E
A
CWDGD
P
L
K
R
P
----
L
L
G
-------
I
V
Q
P
M
L
Q
G
I
M
N
R
L
CKSNSEQPNRGLDDST---------------------------------------------------
3
PsiBlast_PDB
85.94
30%
-92
- C1 -
3CBL
3
A:
[110-375]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
N
H
E
D
L
----------
V
L
G
E
Q
I
G
R
G
N
F
G
E
V
F
S
G
------
R
----
L
----------------
R
----
A
-------
D
---
N
-----
T
L
V
A
V
K
S
C
R
E
T
L
P
P
--
D
L
-
K
---
A
K
F
L
Q
E
A
R
I
L
K
Q
Y
-
S
H
P
N
I
V
R
L
I
G
V
C
T
Q
---------
K
-------
Q
--------------
P
I
Y
I
V
M
E
----
L
-----
V
-----
Q
----
G
G
D
---
F
L
---
T
F
L
----------
R
T
EG
A
---
R
L
R
V
K
T
L
L
Q
M
V
G
D
A
A
A
G
M
E
Y
L
E
S
K
C
C
I
H
R
D
L
A
A
R
N
C
L
V
T
E
K
N
V
L
K
I
S
D
F
G
M
S
R
-----
E
-----
E
A
DGVY-
A
--
A
-
S
G
G
L
R
Q
V
P
V
K
W
T
-
A
P
E
A
L
N
-
Y
-
G
--------
R
-
Y
S
S
E
S
D
V
W
S
F
G
I
----
L
L
W
E
T
F
S
L
G
A
S
P
Y
---
P
N
-----
L
--------
S
N
Q
-----------
Q
T
R
E
F
V
-------
E
K
G
G
R
L
P
C
P
E
L
C
P
----
D
A
V
F
R
L
M
E
Q
C
W
A
Y
E
P
G
Q
R
P
----
S
F
S
-------
T
I
Y
Q
E
L
Q
S
I
R
K
R
H
-------------------------------------------------------------------
2
PsiBlast_PDB
81.60
30%
-91
- C1 -
3BKB
7
A:
[110-375]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
N
H
E
D
L
----------
V
L
G
E
Q
I
G
R
G
N
F
G
E
V
F
S
G
------
R
----
L
----------------
R
----
A
-------
D
---
N
-----
T
L
V
A
V
K
S
C
R
E
T
L
P
P
--
D
L
-
K
---
A
K
F
L
Q
E
A
R
I
L
K
Q
Y
-
S
H
P
N
I
V
R
L
I
G
V
C
T
Q
---------
K
-------
Q
--------------
P
I
Y
I
V
M
E
----
L
-----
V
-----
Q
----
G
G
D
---
F
L
---
T
F
L
----------
R
T
EG
A
---
R
L
R
V
K
T
L
L
Q
M
V
G
D
A
A
A
G
M
E
Y
L
E
S
K
C
C
I
H
R
D
L
A
A
R
N
C
L
V
T
E
K
N
V
L
K
I
S
D
F
G
M
S
R
-----
E
-----
E
A
DG
V
Y
-
A
--
A
-
S
G
G
L
R
Q
V
P
V
K
W
T
-
A
P
E
A
L
N
-
Y
-
G
--------
R
-
Y
S
S
E
S
D
V
W
S
F
G
I
----
L
L
W
E
T
F
S
L
G
A
S
P
Y
---
P
N
-----
L
--------
S
N
Q
-----------
Q
T
R
E
F
V
-------
E
K
G
G
R
L
P
C
P
E
L
C
P
----
D
A
V
F
R
L
M
E
Q
C
W
A
Y
E
P
G
Q
R
P
----
S
F
S
-------
T
I
Y
Q
E
L
Q
S
I
R
K
R
H
-------------------------------------------------------------------
34
Fugue
75.27
18%
-64
- C1 -
3C4Z
1
RK_BOVIN
A:
[31-533]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
R
K
Y
L
A
R
L
K
L
P
P
L
S
K
C
E
A
L
R
E
S
L
D
L
G
F
E
G
M
---
C
L
E
Q
P
I
G
K
R
L
F
Q
Q
F
L
R
T
---
H
E
Q
H
G
P
A
L
Q
L
W
K
D
I
E
D
Y
D
T
A
D
D
A
L
R
P
Q
K
A
Q
A
L
R
A
A
Y
---
L
-
E
P
Q
A
Q
L
F
C
S
F
L
D
A
E
T
V
A
R
A
R
A
G
--
G
L
F
Q
P
L
L
R
A
V
L
A
H
L
G
Q
A
P
F
Q
E
F
L
D
S
L
Y
F
L
R
F
L
Q
W
K
W
L
E
A
QPMGEDW
F
L
D
F
R
V
L
G
R
G
G
F
G
E
V
F
A
C
------
Q
----
M
----------------
K
----
A
-------
T
---
G
-----
K
L
Y
A
C
K
K
---
L
N
K
K
--
R
L
-
K
-
K
R
K
G
Y
Q
G
A
M
V
E
K
K
I
L
A
K
V
H
S
R
F
-----
I
V
S
---------
L
-------
A
-------
Y
A
F
E
T
K
T
D
L
C
L
V
M
T
----
I
-----
M
-----
N
G---
G
-
D
---
I
R
---
Y
H
I
YNVDED----
N
---
P
---
G
F
Q
E
P
R
A
I
F
Y
T
A
Q
I
V
S
G
L
E
H
L
H
Q
R
N
I
I
Y
R
D
L
K
P
E
N
V
L
L
D
D
D
G
N
V
R
I
S
D
L
G
L
A
V
E
L
K
--
A
-----
G
Q
-----
T
--
K
-
T
K
G
Y
A
G
T
P
G
F
-
M
-
A
P
E
-
L
L
-
L
-
G
--------
E
E
Y
D
F
S
V
D
Y
F
A
L
G
V
----
T
L
Y
E
M
I
A
-
A
R
G
P
F
---
R
A
R
G
E
K
-
V
--------
E
N
K
-----------
E
L
K
Q
R
V
-------
L
E
Q
-
A
---
V
T
Y
P
D
-
K
F
S
P
A
S
K
D
F
C
E
A
L
L
Q
K
D
P
E
K
R
L
----
G
F
R
DGSC
D
G
L
R
T
H
P
L
F
R
D
I
S
W
R
Q
L
E
A
G
M
L
T
P
P
F
V
P
D
S
R
T
VYAKNGAFSG
V
A
F
E
K
A
D
T
E
F
F
Q
E
F
A
SGTC
P
I
P
W
Q
E
E
M
I
E
T
G
V
F
G
D
L
N
VWRP
8
PsiBlast_PDB
74.73
29%
-99
- C1 -
3SXS
1
A:
[12-262]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
K
E
L
G
S
G
Q
F
G
V
V
K
L
-------
G
----
K
----------------
W
----
K
-------
G
---
Q
-----
Y
D
V
A
V
K
----
M
I
K
E
--
G
S
-
M
-
S
E
D
E
F
F
Q
E
A
Q
T
M
M
K
L
-
S
H
P
K
L
V
K
F
Y
G
V
C
------------------------------
S
K
E
Y
P
I
Y
I
V
T
E
----
Y
-----
I
-----
S
----
N
-
G
C--
L
L
---
N
Y
L
----------
R
---
S
HGK
G
L
E
P
S
Q
L
L
E
M
C
Y
D
V
C
E
G
M
A
F
L
E
S
H
Q
F
I
H
R
D
L
A
A
R
N
C
L
V
D
R
D
L
C
V
K
V
S
D
F
G
M
T
R
Y
V
L
--
D
-----
D
Q
-----
Y
--
V
-
S
S
V
G
T
K
F
P
V
K
-
W
S
A
P
E
-
V
F
H
Y
-
F
--------
K
-
Y
S
S
K
S
D
V
W
A
F
G
I
----
L
M
W
E
V
F
S
-
L
G
-
K
M
---
P
Y
D
L
---
Y
--------
T
N
S
-----------
E
V
V
L
K
V
-------
S
Q
G
H
R
---
L
Y
R
P
H
-
L
A
S
D
T
I
Y
Q
I
M
Y
S
C
W
H
E
L
P
E
K
R
P
T
F
Q
Q
L
L
S
-------
S
I
E
P
L
R
E
-------------------------------------------------------------------------
58
HHSearch
74.01
27%
-87
- C1 -
4CKJ
16
A:
[26-312]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
G
K
T
L
G
E
G
E
F
G
K
V
V
K
A
------
T
----
A
F
H--------------
L
----
K
-------
G
RA
G
Y
-----
T
T
V
A
V
K
M
---
L
K
E
N
A-
S
P
-
S
-
E
L
R
D
L
L
S
E
F
N
V
L
K
Q
V
-
N
H
P
H
V
I
K
L
Y
G
A
C
S
Q
---------
D
G
P
L
L
L
I
V
E
-------
Y
A
K
Y
G
S
L
R
G
F
L
R
E
S
RKV----------------------------------------------
R
---
A
L
T
M
G
D
L
I
S
F
A
W
Q
I
S
Q
G
M
Q
Y
L
A
E
M
K
L
V
H
R
D
L
A
A
R
N
I
L
V
A
E
G
R
K
M
K
I
S
D
F
G
L
S
R
-----
D
VYEE-
D
S
-----
Y
--
V
K
R
S
Q
G
R
I
P
V
K
W
-
M
-
A
I
E
-
S
L
-
F
D
H
--------
I
-
Y
T
T
Q
S
D
V
W
S
F
G
V
----
L
L
W
E
I
V
T
L
G
G
N
P
Y
---
P
G
-----
I
--------
P
P
E
-----------
R
L
F
N
L
L
-------
K
T
G
H
R
---
M
E
R
P
D
-
N
C
S
E
E
M
Y
R
L
M
L
Q
C
W
K
Q
E
P
D
K
R
P
----
V
F
A
-------
D
I
S
K
D
L
E
K
M
M
V
K
R
R
------------------------------------------------------------------
38
HHSearch
72.75
26%
-89
* C1 *
2PVF
1
A:
[37-321]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
----------
T
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
M
A
------
E
----
A
----------------
V
----
G
IDKDKP-----------
V
T
V
A
V
K
M
---
L
K
D
D
A-
T
E
-
K
-
D
L
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
---------
D
G
P
L
Y
V
I
V
E
-------
Y
A
S
K
G
N
L
R
E
Y
L
R
A
R
----
R
-----
P
PGMEY
S
----
Y
-------------------------------
Q
M
T
F
K
D
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
N
N
V
M
K
I
A
D
F
G
L
A
R
-----
D
-----
I
N
NIDYY
K
--
K
-
T
T
N
G
R
L
P
V
K
W
-
M
-
A
P
E
-
A
L
-
F
D
R
--------
V
-
Y
T
H
Q
S
D
V
W
S
F
G
V
----
L
M
W
E
I
F
T
L
G
G
S
P
Y
---
P
G
-----
I
--------
P
V
E
-----------
E
L
F
K
L
L
-------
K
E
G
H
R
---
M
D
K
P
A
-
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
----
T
F
K
-------
Q
L
V
E
D
L
D
R
I
L
T
L
T
T
------------------------------------------------------------------
42
HHSearch
72.06
25%
-90
- C1 -
3UGC
1
A:
[12-292]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
----------
K
F
L
Q
Q
L
G
K
G
N
F
G
S
V
E
M
C
------
R
YDPL
Q
----------------
D
----
N
-------
T
---
G
-----
E
V
V
A
V
K
K
---
L
Q
H
S
--
T
E
-
E
-
H
L
R
D
F
E
R
E
I
E
I
L
K
S
L
-
Q
H
D
N
I
V
K
Y
K
G
V
C
Y
S
AGRR
N
L
K
L
I
M
-------
E
-------
Y
L
P
Y
G
S
L
R
D
Y
L
-------------------
Q
----------------
K
H
----------
K
---
E
---
R
I
D
H
I
K
L
L
Q
Y
T
S
Q
I
C
K
G
M
E
Y
L
G
T
K
R
Y
I
H
R
D
L
A
T
R
N
I
L
V
E
N
E
N
R
V
K
I
G
D
F
G
L
T
K
-------------------------
P
G
E
S
P
I
F
W
-
Y
-
A
P
E
-
S
L
-
T
E
S
--------
K
-
F
S
V
A
S
D
V
W
S
F
G
V
----
V
L
Y
E
L
F
T
-
Y
I
E
K
S
KS
P
P
A
E
F
M
R
M
I
GNDKQG
Q
M
I
V
F
-----------
H
L
I
E
L
L
-------
K
N
N
G
R
---
L
P
R
P
D
-
G
C
P
D
E
I
Y
M
I
M
T
E
C
W
N
N
N
V
N
Q
R
P
----
S
F
R
-------
D
L
A
L
R
V
D
Q
I
R
D
N
--------------------------------------------------------------------
7
PsiBlast_PDB
71.73
29%
-99
- C1 -
3SXR
1
BMX_HUMAN
A:
[12-262]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
K
E
L
G
S
----
V
V
K
L
-------
G
----
K
----------------
W
----
K
-------
G
---
Q
-----
Y
D
V
A
V
K
----
M
I
K
E
--
G
S
-
M
-
S
E
D
E
F
F
Q
E
A
Q
T
M
M
K
L
-
S
H
P
K
L
V
K
F
Y
G
V
C
------------------------------
S
K
E
Y
P
I
Y
I
V
T
E
----
Y
-----
I
-----
S
----
N
-
G
C--
L
L
---
N
Y
L
----------
R
---
S
HGK
G
L
E
P
S
Q
L
L
E
M
C
Y
D
V
C
E
G
M
A
F
L
E
S
H
Q
F
I
H
R
D
L
A
A
R
N
C
L
V
D
R
D
L
C
V
K
V
S
D
F
G
M
T
R
Y
V
L
--
D
-----
D
Q
-----
Y
--
V
-
S
S
V
G
T
K
F
P
V
K
-
W
S
A
P
E
-
V
F
H
Y
-
F
--------
K
-
Y
S
S
K
S
D
V
W
A
F
G
I
----
L
M
W
E
V
F
S
-
L
G
-
K
M
---
P
Y
D
L
---
Y
--------
T
N
S
-----------
E
V
V
L
K
V
-------
S
Q
G
H
R
---
L
Y
R
P
H
-
L
A
S
D
T
I
Y
Q
I
M
Y
S
C
W
H
E
L
P
E
K
R
P
T
F
Q
Q
L
L
S
-------
S
I
E
P
L
R
E
-------------------------------------------------------------------------
43
HHSearch
71.26
25%
-92
- C1 -
4AOJ
1
NTRK1_HUMAN
A:
[44-318]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
K
W
E
L
G
E
G
A
F
G
K
V
F
L
A
------
E
----
C
----------------
H
NLLP------------
K
-----
M
L
V
A
V
K
A
---
L
K
E
A
--
S
E
-
S
-
A
R
Q
D
F
Q
R
E
A
E
L
L
T
M
L
-
Q
H
Q
H
I
V
R
F
F
G
V
C
T
E
---------
G
RP
L
L
M
V
F
E
-------
Y
M
R
H
G
D
L
N
R
F
--------------
L
-----
R
----
S
-
H
GPD------------------
P
---
G
---
P
L
G
L
G
Q
L
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
G
Q
G
L
V
V
K
I
G
D
F
G
-----------------------------
T
M
L
P
I
R
W
-
M
-
P
P
E
-
S
I
-
L
Y
R
--------
K
-
F
T
T
E
S
D
V
W
S
F
G
V
----
V
L
W
E
I
F
T
Y
G
K
Q
P
W
---
Y
----
Q
-
L
--------
S
N
T
-----------
E
A
I
D
C
I
-------
T
Q
G
R
E
---
L
E
R
P
R
-
A
C
P
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
----
S
I
K
-------
D
V
H
A
R
L
Q
A
L
A
Q
A
P
P
------------------------------------------------------------------
54
HHSearch
70.66
25%
-92
- C1 -
4OT5
3
A:
[27-281]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
------
K
----
W
---------------------
R
-------
G
---
Q
-----
Y
D
V
A
I
K
M
---
I
K
E
---
G
S
-
M
-
S
E
D
E
F
I
E
E
A
K
V
M
M
N
L
-
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
---------
Q
-------
R
P
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
--------------------------------
Y
L
---
R
E
A
----------
R
---
H
---
A
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
-----
Y
VLDD-
E
Y
-----
T
--
S
-
S
V
G
S
K
F
P
V
R
W
-
S
-
P
P
E
-
V
L
-
M
Y
S
--------
K
-
F
S
S
K
S
D
I
W
A
F
G
V
----
L
M
W
E
I
Y
S
L
G
K
M
P
Y
---
E
----
R
-
F
--------
T
N
S
-----------
E
T
A
E
H
I
-------
A
Q
G
L
R
---
L
Y
R
P
H
-
L
A
S
A
A
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
----
T
F
K
-------
I
L
L
S
N
I
L
D
V
M
D
E
E
-------------------------------------------------------------------
33
Fugue
69.93
18%
-57
- C1 -
2ACX
1
GRK6_HUMAN
A:
[14-532]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
A
R
K
G
K
S
K
K
W
R
Q
M
L
Q
F
P
H
I
S
Q
C
E
E
L
R
L
S
L
E
R
D
Y
H
S
L
C
ER
N
P
I
G
R
L
L
F
R
E
F
C
A
T
R
P
E
L
S
R
C
V
A
F
L
D
G
V
A
E
Y
E
V
T
P
D
D
K
R
-
K
A
C
G
R
N
L
T
Q
N
F
L
S
H
T
G
P
D
L
I
P
E
V
P
R
Q
L
V
T
N
C
T
Q
R
L
E
Q
G
P
C
K
D
L
F
Q
E
L
T
R
L
T
H
E
Y
L
S
V
A
P
F
A
D
Y
L
D
S
I
Y
F
N
R
F
L
Q
W
K
W
L
E
R
Q
P
VTKNT
F
----
R
Q
Y
R
V
L
G
K
G
G
F
G
E
V
C
A
C
------
Q
----
V
----------------
R
----
A
-------
T
---
G
-----
K
M
Y
A
C
K
K
---
L
E
K
K
--
R
I
-
K
-
K
R
K
G
E
A
M
A
L
N
E
K
Q
I
L
E
K
V
N
-----
S
R
F
V
V
S
---------
L
-------
A
-------
Y
A
Y
E
T
K
D
A
L
C
L
V
L
T
----
L
MNGGD
L
-----
K
----
F
-
H
---
I
Y
---
H
M
G
----------
Q
---
A
---
G
F
P
E
A
R
A
V
F
Y
A
A
E
I
C
C
G
L
E
D
L
H
R
E
R
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
D
H
G
H
I
R
I
S
D
L
G
L
A
V
H
V
---
P
-----
E
G
-----
Q
--
T
-
I
K
G
R
V
G
T
V
G
Y
-
M
-
A
P
E
-
V
V
-
K
-
N
E
-------
R
-
Y
T
F
S
P
D
W
W
A
L
G
C
----
L
L
Y
E
M
I
A
-
G
Q
S
P
F
---
Q
Q
R
K
K
K
-
I
--------
K
R
E
-----------
E
V
E
R
L
V
-------
K
E
V
P
E
---
E
Y
S
-
E
-
R
F
S
P
Q
A
R
S
L
C
S
Q
L
L
C
K
D
P
A
E
R
L
----
G
C
R
GGS
A
R
E
V
K
E
H
P
L
F
K
K
L
N
F
K
R
L
G
A
G
M
L
E
P
P
F
K
P
D
P
Q
A
IYCE
P
T
D
Q
D
F
Y
Q
K
F
ATGSVP
I
P
W
Q
N
E
M
V
E
T
E
C
F
Q
E
L
N
VFGLDGS-------
53
HHSearch
69.87
26%
-81
- C1 -
4BKJ
10
DDR1_HUMAN
A:
[13-306]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
F
K
E
K
L
G
E
G
Q
F
G
E
V
H
L
C
------
E
----
V
D
SPQDLVSLDFPLNVR
K
----
G
-------
H
---
P
-----
L
L
V
A
V
K
I
---
L
R
P
D
--
A
T
-
K
N
A
R
N
D
F
L
K
E
V
K
I
M
S
R
L
-
K
D
P
N
I
I
R
L
L
G
V
C
V
Q
---------
D
DP
L
C
M
I
T
D
-------
Y
M
E
N
G
D
L
N
Q
F
L
S
A
H
----
Q
-----
L
-----
E
----
D
---------------------------
P
---
T
I
S
Y
P
M
L
L
H
V
A
A
Q
I
A
S
G
M
R
Y
L
A
T
L
N
F
V
H
R
D
L
A
T
R
N
C
L
V
G
E
N
F
T
I
K
I
A
D
F
G
M
S
R
-----
N
-----
L
Y
AGDYY-------
R
A
V
L
P
I
R
W
-
M
-
A
W
E
-
C
I
L
M
-
G
--------
K
-
F
T
T
A
S
D
V
W
A
F
G
V
----
T
L
W
E
V
L
M
-
L
C
R
A
Q
---
P
--
F
G
Q
L
---------
T
D
E
-----------
Q
V
I
E
N
A
G
E
F
F
R
DQ
G
R
Q
V
Y
---
L
S
R
P
P
-
A
C
P
Q
G
L
Y
E
L
M
L
R
C
W
S
R
E
S
E
Q
R
P
----
P
F
S
-------
Q
L
H
R
F
L
A
E
D
A
L
N
T
V
------------------------------------------------------------------
51
HHSearch
68.98
27%
-81
- C1 -
3TT0
1
FGFR1_HUMAN
A:
[71-353]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
----------
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
------
E
----
A
----------------
I
----
G
LDKDKPN
R
---
V
-----
T
K
V
A
V
K
M
---
L
K
S
D
A-
T
E
-
K
-
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
---------
D
-------
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
--------------
L
-----
Q
----
A
-
R
---
R
P
---
P
G
L
EYSYNPSHNP
E
---
E
---
Q
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
N
V
M
K
I
A
D
F
G
L
A
R
-----
D
-----
I
H
H
I
D
YY
K
--
K
-
T
T
N
G
R
L
P
V
K
W
-
M
-
A
P
E
-
A
L
-
F
-
D
R-------
I
-
Y
T
H
Q
S
D
V
W
S
F
G
V
----
L
L
W
E
I
F
T
L
G
G
S
P
Y
---
P
G
-----
V
--------
P
V
E
-----------
E
L
F
K
L
L
-------
K
E
G
H
R
---
M
D
K
P
S
-
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
----
T
F
K
-------
Q
L
V
E
D
L
D
R
I
V
A
L
T
S
N
Q
E
---------------------------------------------------------------
39
HHSearch
68.27
28%
-86
- C1 -
2XIR
1
A:
[28-311]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
L
----------
K
L
G
K
P
L
G
R
G
A
F
G
Q
V
I
E
A
------
D
----
A
----------------
F
----
G
-------
I
---
D
KTA
T
C
R
T
V
A
V
K
M
---
L
K
E
G
--
A
T
H
S
-
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
K
P
GG
P
L
M
V
I
-
V
-------
E
-------
F
C
K
F
G
N
L
S
T
Y
L
R
S
-----------------
K
----
R
-
N
---
E
F
VPY--
Y
----------
K
---
D
---
F
L
T
L
E
H
L
I
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
E
K
N
V
V
K
I
C
D
F
G
L
A
R
DIYKD
P
-----
D
Y
-----
V
--
R
-
K
G
D
A
R
L
P
L
K
W
-
M
-
A
P
E
-
T
I
-
F
D
R
--------
V
-
Y
T
I
Q
S
D
V
W
S
F
G
V
----
L
L
W
E
I
F
S
L
G
A
S
P
Y
---
P
G
----
V
K
--------
I
D
E
-----------
E
F
C
R
R
L
-------
K
E
G
T
R
---
M
R
A
P
D
-
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
----
T
F
S
-------
E
L
V
E
H
L
G
N
L
L
Q
A
N
A
------------------------------------------------------------------
14
PsiBlast_PDB
66.57
29%
-77
- C1 -
3E64
1
A:
[9-276]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
H
L
----------
K
F
L
Q
Q
L
G
K
G
N
F
G
S
V
E
M
C
R
YDPLQ
D
----
N
----------------
T
----
G
-------
E
----------
V
V
A
V
K
K
---
L
Q
H
S
--
T
E
-
E
-
H
L
R
D
F
E
R
E
I
E
I
L
K
S
L
-
Q
H
D
N
I
V
K
Y
K
G
V
C
---------------------------
Y
S
A
G
R
R
-
N
L
K
L
I
M
E
----
Y
-----
L
-----
P
YGS
L
R
-
D
---
Y
L
---
Q
K
H
----------
K
---
E
---
R
I
D
H
I
K
L
L
Q
Y
T
S
Q
I
C
K
G
M
E
Y
L
G
T
K
R
Y
I
H
R
D
L
A
T
R
N
I
L
V
E
N
E
N
R
V
K
I
G
D
F
G
L
T
K
V
L
PQD
K
-----
E
Y
-----
Y
--
K
-
V
K
E
P
G
E
S
P
I
F
W
Y
-
A
P
E
-
S
L
-
T
E
S
--------
K
-
F
S
V
A
S
D
V
W
S
F
G
V
V
L
Y
E
L
F
T
Y
I
-
E
-
K
S
K
S
P
---
P
A
E
F
M
R
M
I
--------
G
N
D
K
Q
G
Q
M
I
V
F
H
L
I
E
L
L
K
N
N
-------
G
R
L
P
R
---
P
D
G
C
P
----
D
E
I
Y
M
I
M
T
E
C
W
N
N
N
V
N
Q
R
P
----
S
F
R
-------
D
L
A
L
R
V
D
Q
I
R
D
N
M
A
------------------------------------------------------------------
16
PsiBlast_PDB
65.82
29%
-78
- C1 -
2W1I
1
JAK2_HUMAN
A:
[41-308]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
H
L
----------
K
F
L
Q
Q
L
G
K
G
N
F
G
S
V
E
M
C
R
YDPLQ
D
----
N
----------------
T
----
G
-------
E
----------
V
V
A
V
K
K
---
L
Q
H
S
--
T
E
-
E
-
H
L
R
D
F
E
R
E
I
E
I
L
K
S
L
-
Q
H
D
N
I
V
K
Y
K
G
V
C
---------------------------
Y
S
-----
N
L
K
L
I
M
E
----
Y
-----
L
-----
P
YGS
L
R
-
D
---
Y
L
---
Q
K
H
----------
K
---
E
---
R
I
D
H
I
K
L
L
Q
Y
T
S
Q
I
C
K
G
M
E
Y
L
G
T
K
R
Y
I
H
R
D
L
A
T
R
N
I
L
V
E
N
E
N
R
V
K
I
G
D
F
G
L
T
K
V
L
P
QD
K
-----
E
Y
-----
Y
--
K
-
V
K
E
P
G
E
S
P
I
F
W
Y
-
A
P
E
-
S
L
-
T
E
S
--------
K
-
F
S
V
A
S
D
V
W
S
F
G
V
V
L
Y
E
L
F
T
Y
I
-
E
-
K
S
K
S
P
---
P
A
E
F
M
R
M
I
--------
G
N
D
K
Q
G
Q
M
I
V
F
H
L
I
E
L
L
K
N
N
-------
G
R
L
P
R
---
P
D
G
C
P
----
D
E
I
Y
M
I
M
T
E
C
W
N
N
N
V
N
Q
R
P
----
S
F
R
-------
D
L
A
L
R
V
D
Q
I
R
D
Q
M
A
G
-----------------------------------------------------------------
41
HHSearch
65.18
26%
-84
- C1 -
1T46
1
?
A:
[25-306]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
----------
S
F
G
K
T
L
G
A
G
A
F
G
K
V
V
E
A
------
T
----
A
----------------
Y
----
G
LIKSD--
A
---
A
-----
M
T
V
A
V
K
M
---
L
K
P
S
--
A
H
L
T
-
E
R
E
A
L
M
S
E
L
K
V
L
S
Y
L
G
N
H
M
N
I
V
N
L
L
G
A
C
T
I
---------
G
GP
T
L
V
I
T
E
-------
Y
C
C
Y
G
D
L
L
N
F
L
R
R
K
R
DSF---------------------------------------------
L
---
A
L
D
L
E
D
L
L
S
F
S
Y
Q
V
A
K
G
M
A
F
L
A
S
K
N
C
I
H
R
D
L
A
A
R
N
I
L
L
T
H
G
R
I
T
K
I
C
D
F
G
L
A
R
-----
D
IKNDS
N
Y
-----
V
--
V
-
K
G
N
A
R
L
P
V
K
W
-
M
-
A
P
E
-
S
I
F
N
-
C
--------
V
-
Y
T
F
E
S
D
V
W
S
Y
G
I
----
F
L
W
E
L
F
S
L
G
S
S
P
Y
---
P
G
----
M
P
--------
V
D
S
-----------
K
F
Y
K
M
I
-------
K
E
G
F
R
---
M
L
S
P
E
-
H
A
P
A
E
M
Y
D
I
M
K
T
C
W
D
A
D
P
L
K
R
P
----
T
F
K
-------
Q
I
V
Q
L
I
E
K
Q
I
S
E
S
T
N
-----------------------------------------------------------------
13
PsiBlast_PDB
65.06
29%
-75
- C1 -
3E63
1
A:
[9-276]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
H
L
----------
K
F
L
Q
Q
L
G
K
G
N
F
G
S
V
E
M
C
R
YDPLQ
D
----
N
----------------
T
----
G
-------
E
----------
V
V
A
V
K
K
---
L
Q
H
S
--
T
E
-
E
-
H
L
R
D
F
E
R
E
I
E
I
L
K
S
L
-
Q
H
D
N
I
V
K
Y
K
G
V
C
---------------------------
Y
S
A
G
R
R
-
N
L
K
L
I
M
E
----
Y
-----
L
-----
P
YGS
L
R
-
D
---
Y
L
---
Q
K
H
----------
K
---
E
---
R
I
D
H
I
K
L
L
Q
Y
T
S
Q
I
C
K
G
M
E
Y
L
G
T
K
R
Y
I
H
R
D
L
A
T
R
N
I
L
V
E
N
E
N
R
V
K
I
G
D
F
G
L
T
K
V
L
P
QD
K
-----
E
Y
-----
Y
--
K
-
V
K
E
P
G
E
S
P
I
F
W
Y
-
A
P
E
-
S
L
-
T
E
S
--------
K
-
F
S
V
A
S
D
V
W
S
F
G
V
V
L
Y
E
L
F
T
Y
I
-
E
-
K
S
K
S
P
---
P
A
E
F
M
R
M
I
--------
G
N
D
K
Q
G
Q
M
I
V
F
H
L
I
E
L
L
K
N
N
-------
G
R
L
P
R
---
P
D
G
C
P
----
D
E
I
Y
M
I
M
T
E
C
W
N
N
N
V
N
Q
R
P
----
S
F
R
-------
D
L
A
L
R
V
D
Q
I
R
D
N
M
A
------------------------------------------------------------------
18
PsiBlast_PDB
63.70
29%
-72
- C1 -
3TJC
1
JAK2_HUMAN
A:
[13-280]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
H
L
----------
K
F
L
Q
Q
L
G
K
G
N
F
G
S
V
E
M
C
R
YDPLQ
D
----
N
----------------
T
----
G
-------
E
----------
V
V
A
V
K
K
---
L
Q
H
S
--
T
E
-
E
-
H
L
R
D
F
E
R
E
I
E
I
L
K
S
L
-
Q
H
D
N
I
V
K
Y
K
G
V
C
---------------------------
Y
S
-----
N
L
K
L
I
M
E
----
Y
-----
L
-----
P
YGS
L
R
-
D
---
Y
L
---
Q
K
H
----------
K
---
E
---
R
I
D
H
I
K
L
L
Q
Y
T
S
Q
I
C
K
G
M
E
Y
L
G
T
K
R
Y
I
H
R
D
L
A
T
R
N
I
L
V
E
N
E
N
R
V
K
I
G
D
F
G
L
T
K
V
L
PQD
K
-----
E
Y
-----
Y
--
K
-
V
K
E
P
G
E
S
P
I
F
W
Y
-
A
P
E
-
S
L
-
T
E
S
--------
K
-
F
S
V
A
S
D
V
W
S
F
G
V
V
L
Y
E
L
F
T
Y
I
-
E
-
K
S
K
S
P
---
P
A
E
F
M
R
M
I
--------
G
N
D
KQG
Q
M
I
V
F
H
L
I
E
L
L
K
N
N
-------
G
R
L
P
R
---
P
D
G
C
P
----
D
E
I
Y
M
I
M
T
E
C
W
N
N
N
V
N
Q
R
P
----
S
F
R
-------
D
L
A
L
R
V
D
Q
I
R
D
N
M
A
G
-----------------------------------------------------------------
59
HHSearch
59.46
24%
-78
- C1 -
2Y4I
1
B:
[35-300]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
----------
E
I
G
E
L
I
G
K
G
R
F
G
Q
V
Y
H
G
------
R
---------------------
W
----
H
-------
G
---
E
-------
V
A
I
R
L
---
I
D
I
E
RD
N
E
-
D
-
Q
L
K
A
F
K
R
E
V
M
A
Y
R
Q
T
-
R
H
E
N
V
V
L
F
M
G
A
C
M
S
---------
P
-------
P
HLAIITS
L
C
K
G
R
T
L
Y
-----------------------------
S
---
V
V
---
R
D
A
----------
K
---
I
---
V
L
D
V
N
K
T
R
Q
I
A
Q
E
I
V
K
G
M
G
Y
L
H
A
K
G
I
L
H
K
D
L
K
S
K
N
V
F
Y
D
---
K
V
V
I
T
D
F
G
L
F
S
-------------------ED
K
-
L
R
I
Q
N
G
W
L
C
H
-
L
-
A
P
E
-
I
I
-
R
-
Q
LSPDEDKL
P
-
F
S
K
H
S
D
V
F
A
L
G
T
----
I
W
Y
E
L
H
A
-
R
E
W
P
F
-------
K
T
Q
---------
P
A
E
-----------
A
I
I
W
Q
M
-------
G
T
G
M
K
---
P
N
L
S
Q
I
G
M
G
K
E
I
S
D
I
L
L
F
C
W
A
F
E
Q
E
E
R
P
----
T
F
T
-------
K
L
M
D
M
L
E
K
L
-----------------------------------------------------------------------