@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : DYR1A_HUMAN: (2015-10-06 )
MHTGGETSACKPSSVRLAPSFSFHAAGLQMAGQMPHSHQYSDRRQPNISDQQVSALSYSDQIQQPLTNQVMPDIVMLQRRMPQTFRDPATAPLRKLSVDLIKTYKHINEVYYAKKKRRHQQGQGDDSSHKKERKVYNDGYDDDNYDYIVKNGEKWMDRYEIDSLIGKGSFGQVVKAYDRVEQEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDTEMKYYIVHLKRHFMFRNHLCLVFEMLSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTALLFLATPELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLLGMPYDLAIDMWSLGCILVEMHTGEPLFSGANEVDQMNKIVEVLGIPPAHILDQAPKARKFFEKLPDGTWNLKKTKDGKREYKPPGTRKLHNILGVETGGPGGRRAGESGHTVADYLKFKDLILRMLDYDPKTRIQPYYALQHSFFKKTADEGTNTSNSVSTSPAMEQSQSSGTTSSTSSSSGGSSGTSNSGRARSDPTHQHRHSGGHFTAAVQAMDCETHSPQVRQQFPAPLGWSGTEAPTQVTVETHPVQETTFHVAPQQNALHHHHGNSSHHHHHHHHHHHHHGQQALGNRTRPRVYNSPTNSSSTQDSMEVGHSHHSMTSLSSSTTSSSTSSSSTGNQGNQAYQNRPVAANTLDFGQNGAMDVNLTVYSNPRQETGIAGHPTYQFSANTGPAHYMTEGHLTMRQGADREESPMTGVCVQQSPVASS
Atome Classification :
(11 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150....-...160.......170.......180........190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290......-----------------.300.......310.......320.......330.......340.......350.......360.......370.......380.......390.....-----------..400.......410--........420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MHTGGETSACKPS
S
V
R
LAPSFS
F
H
A
A
G
L
Q
M
A
GQMPHSHQYSDRRQPNIS
D
Q
Q
V
S
ALS
Y
S
D
Q
I
QQ
P
L
T
N
QV
M
P
D
I
V
M
L
Q
R
RM
P
Q
T
FRDPATA
P
L
R
K
L
S
V
D
L
I
K
T
Y
K
H
I
N
E
V
Y
Y
A
K
K
K
R
RHQQGQGDDS
S
H
K
K
E
R
K
VYNDGYDDDNY
D
Y
I
VKN
G
E
K
W
M
-
D
R
Y
E
I
D
S
L
IGKG
S
F
G
Q
V
V
K
A
Y
D
R
V
E
-Q
E
W
V
A
I
K
I
I
KN
K
K
A
F
L
N
Q
A
Q
I
E
V
R
L
L
E
L
M
N
KHDTE
M
K
Y
Y
I
V
H
L
K
R
H
F
M
F
R
N
H
L
C
L
V
F
E
M
L
S
Y
N
L
Y
D
L
L
RNTNFR
G
V
S
L
N
L
T
R
K
F
A
Q
Q
M
C
T
A
L
L
F
LATP
E
L
S
I
I
H
CDLKPE
N
I
L
L
CNP-----------------KR
S
A
I
K
I
V
DFGSS
C
Q
L
G
Q
R
I
Y
Q
Y
I
Q
S
R
FYRSPE
V
L
LGMP
Y
D
L
A
I
D
M
WS
L
G
C
I
L
V
EMHTGEPLFSG
A
N
E
V
D
Q
M
N
K
I
V
E
V
LGI
P
P
A
H
I
LDQA
P
K
A
R
K
F
F
E
K-----------LPDGTWNLKKTKDG---KREYKPP
G
T
R
K
L
H
N
I
LGVETGGPGGRRAGESG
H
T
V
A
D
Y
L
K
F
K
D
L
I
L
R
M
LDYDPKTRI
Q
P
Y
Y
A
L
Q
H
S
F
F
K
K
T
ADEGTNTSNSVSTSPAMEQSQSSGTTSSTSSSSGGSSGTSNSGRARSDPT
H
Q
HRHSGG
H
F
T
A
A
V
Q
A
MDCETH
S
P
Q
V
R
Q
QFPAPLGWSGTEA
P
T
Q
V
T
V
E
THPVQE
T
T
F
H
VAPQQN
A
L
HHHHGNSSHHHHHHHH
H
H
H
HH
G
Q
Q
A
LGNRTRP
R
V
YNSPTNSSST
Q
D
S
M
E
VGHSHHSMTSLSSSTTSSSTSSSSTGNQGN
Q
A
YQNRPVAANTLDFGQNG
A
M
D
V
N
L
T
V
YSNPRQETGIAGHP
T
Y
Q
F
SANTGPA
H
Y
M
TEG
H
L
T
MRQGADREESPMT
G
V
C
VQQSPVASS
13
PsiBlast_PDB
95.61
99%
-127
- C3 -
4AZE
1
DYR1A_HUMAN
A:
[29-378]
-----------------------------------------------------------------------------------------------------------------------------------
E
R
K
V
Y
N
D
G
Y
D
D
D
N
Y
D
Y
I
V
K
N
G
E
K
W
M
-
D
R
Y
E
I
D
S
L
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
R
V
E
-
Q
E
W
V
A
I
K
I
I
K
N
K
K
A
F
L
N
Q
A
Q
I
E
V
R
L
L
E
L
M
N
K
H
D
T
E
M
K
Y
Y
I
V
H
L
K
R
H
F
M
F
R
N
H
L
C
L
V
F
E
M
L
S
Y
N
L
Y
D
L
L
R
N
T
N
F
R
G
V
S
L
N
L
T
R
K
F
A
Q
Q
M
C
T
A
L
L
F
L
A
T
P
E
L
S
I
I
H
C
D
L
K
P
E
N
I
L
L
C
N
P
-----------------
K
R
S
A
I
K
I
V
D
F
G
S
S
C
Q
L
G
Q
R
I
Y
Q
Y
I
Q
S
R
F
Y
R
S
P
E
V
L
L
G
M
P
Y
D
L
A
I
D
M
W
S
L
G
C
I
L
V
E
M
H
T
G
E
P
L
F
S
G
A
N
E
V
D
Q
M
N
K
I
V
E
V
L
G
I
P
P
A
H
I
L
D
Q
A
P
K
A
R
K
F
F
E
K
-----------
L
P
D
G
T
W
N
L
K
K
T
K
D
G
---
K
R
E
Y
K
P
P
G
T
R
K
L
H
N
I
L
G
V
E
T
G
G
P
G
G
R
R
A
G
E
S
G
H
T
V
A
D
Y
L
K
F
K
D
L
I
L
R
M
L
D
Y
D
P
K
T
R
I
Q
P
Y
Y
A
L
Q
H
S
F
F
K
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
33
PsiBlast_CBE
95.57
99%
-130
- C3 -
2WO6
1
DYR1A_HUMAN
B:
[33-377]
---------------------------------------------------------------------------------------------------------------------------------------
Y
N
D
G
Y
D
D
D
N
Y
D
Y
I
V
K
N
G
E
K
W
M
-
D
R
Y
E
I
D
S
L
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
R
V
E
-
Q
E
W
V
A
I
K
I
I
K
N
K
K
A
F
L
N
Q
A
Q
I
E
V
R
L
L
E
L
M
N
K
H
D
T
E
M
K
Y
Y
I
V
H
L
K
R
H
F
M
F
R
N
H
L
C
L
V
F
E
M
L
S
Y
N
L
Y
D
L
L
R
N
T
N
F
R
G
V
S
L
N
L
T
R
K
F
A
Q
Q
M
C
T
A
L
L
F
L
A
T
P
E
L
S
I
I
H
C
D
L
K
P
E
N
I
L
L
C
N
P
-----------------
K
R
S
A
I
K
I
V
D
F
G
S
S
C
Q
L
G
Q
R
I
Y
Q
Y
I
Q
S
R
F
Y
R
S
P
E
V
L
L
G
M
P
Y
D
L
A
I
D
M
W
S
L
G
C
I
L
V
E
M
H
T
G
E
P
L
F
S
G
A
N
E
V
D
Q
M
N
K
I
V
E
V
L
G
I
P
P
A
H
I
L
D
Q
A
P
K
A
R
K
F
F
E
K
-----------
L
P
D
G
T
W
N
L
K
K
--------
R
E
Y
K
P
P
G
T
R
K
L
H
N
I
L
G
V
E
T
G
G
P
G
G
R
R
A
G
E
S
G
H
T
V
A
D
Y
L
K
F
K
D
L
I
L
R
M
L
D
Y
D
P
K
T
R
I
Q
P
Y
Y
A
L
Q
H
S
F
F
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
48
PsiBlast_CBE
95.46
99%
-127
- C3 -
4AZE
1
DYR1A_HUMAN
C:
[29-378]
-----------------------------------------------------------------------------------------------------------------------------------
E
R
K
V
Y
N
D
G
Y
D
D
D
N
Y
D
Y
I
V
K
N
G
E
K
W
M
-
D
R
Y
E
I
D
S
L
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
R
V
E
-
Q
E
W
V
A
I
K
I
I
K
N
K
K
A
F
L
N
Q
A
Q
I
E
V
R
L
L
E
L
M
N
K
H
D
T
E
M
K
Y
Y
I
V
H
L
K
R
H
F
M
F
R
N
H
L
C
L
V
F
E
M
L
S
Y
N
L
Y
D
L
L
R
N
T
N
F
R
G
V
S
L
N
L
T
R
K
F
A
Q
Q
M
C
T
A
L
L
F
L
A
T
P
E
L
S
I
I
H
C
D
L
K
P
E
N
I
L
L
C
N
P
-----------------
K
R
S
A
I
K
I
V
D
F
G
S
S
C
Q
L
G
Q
R
I
Y
Q
Y
I
Q
S
R
F
Y
R
S
P
E
V
L
L
G
M
P
Y
D
L
A
I
D
M
W
S
L
G
C
I
L
V
E
M
H
T
G
E
P
L
F
S
G
A
N
E
V
D
Q
M
N
K
I
V
E
V
L
G
I
P
P
A
H
I
L
D
Q
A
P
K
A
R
K
F
F
E
K
-----------
L
P
D
G
T
W
N
L
K
K
T
K
D
G
---
K
R
E
Y
K
P
P
G
T
R
K
L
H
N
I
L
G
V
E
T
G
G
P
G
G
R
R
A
G
E
S
G
H
T
V
A
D
Y
L
K
F
K
D
L
I
L
R
M
L
D
Y
D
P
K
T
R
I
Q
P
Y
Y
A
L
Q
H
S
F
F
K
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
49
PsiBlast_CBE
95.33
99%
-128
- C3 -
4AZE
1
DYR1A_HUMAN
B:
[32-378]
--------------------------------------------------------------------------------------------------------------------------------------
V
Y
N
D
G
Y
D
D
D
N
Y
D
Y
I
V
K
N
G
E
K
W
M
-
D
R
Y
E
I
D
S
L
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
R
V
E
-
Q
E
W
V
A
I
K
I
I
K
N
K
K
A
F
L
N
Q
A
Q
I
E
V
R
L
L
E
L
M
N
K
H
D
T
E
M
K
Y
Y
I
V
H
L
K
R
H
F
M
F
R
N
H
L
C
L
V
F
E
M
L
S
Y
N
L
Y
D
L
L
R
N
T
N
F
R
G
V
S
L
N
L
T
R
K
F
A
Q
Q
M
C
T
A
L
L
F
L
A
T
P
E
L
S
I
I
H
C
D
L
K
P
E
N
I
L
L
C
N
P
-----------------
K
R
S
A
I
K
I
V
D
F
G
S
S
C
Q
L
G
Q
R
I
Y
Q
Y
I
Q
S
R
F
Y
R
S
P
E
V
L
L
G
M
P
Y
D
L
A
I
D
M
W
S
L
G
C
I
L
V
E
M
H
T
G
E
P
L
F
S
G
A
N
E
V
D
Q
M
N
K
I
V
E
V
L
G
I
P
P
A
H
I
L
D
Q
A
P
K
A
R
K
F
F
E
K
-----------
L
P
D
G
T
W
N
L
K
K
T
K
D
G
---
K
R
E
Y
K
P
P
G
T
R
K
L
H
N
I
L
G
V
E
T
G
G
P
G
G
R
R
A
G
E
S
G
H
T
V
A
D
Y
L
K
F
K
D
L
I
L
R
M
L
D
Y
D
P
K
T
R
I
Q
P
Y
Y
A
L
Q
H
S
F
F
K
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
94.93
99%
-124
- C3 -
2WO6
1
DYR1A_HUMAN
A:
[30-378]
------------------------------------------------------------------------------------------------------------------------------------
R
K
V
Y
N
D
G
Y
D
D
D
N
Y
D
Y
I
V
K
N
G
E
K
W
M
-
D
R
Y
E
I
D
S
L
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
R
V
E
-
Q
E
W
V
A
I
K
I
I
K
N
K
K
A
F
L
N
Q
A
Q
I
E
V
R
L
L
E
L
M
N
K
H
D
T
E
M
K
Y
Y
I
V
H
L
K
R
H
F
M
F
R
N
H
L
C
L
V
F
E
M
L
S
Y
N
L
Y
D
L
L
R
N
T
N
F
R
G
V
S
L
N
L
T
R
K
F
A
Q
Q
M
C
T
A
L
L
F
L
A
T
P
E
L
S
I
I
H
C
D
L
K
P
E
N
I
L
L
C
N
P
-----------------
K
R
S
A
I
K
I
V
D
F
G
S
S
C
Q
L
G
Q
R
I
Y
Q
Y
I
Q
S
R
F
Y
R
S
P
E
V
L
L
G
M
P
Y
D
L
A
I
D
M
W
S
L
G
C
I
L
V
E
M
H
T
G
E
P
L
F
S
G
A
N
E
V
D
Q
M
N
K
I
V
E
V
L
G
I
P
P
A
H
I
L
D
Q
A
P
K
A
R
K
F
F
E
K
-----------
L
P
D
G
T
W
N
L
K
K
T
-------
R
E
Y
K
P
P
G
T
R
K
L
H
N
I
L
G
V
E
T
G
G
P
G
G
R
R
A
G
E
S
G
H
T
V
A
D
Y
L
K
F
K
D
L
I
L
R
M
L
D
Y
D
P
K
T
R
I
Q
P
Y
Y
A
L
Q
H
S
F
F
K
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
76.78
99%
-84
- C3 -
4YLK
13
DYR1A_HUMAN
A:
[10-357]
-------------------------------------------------------------------------------------------------------------------------------------
K
V
Y
N
D
G
Y
D
D
D
N
Y
D
Y
I
V
K
N
G
E
K
W
M
-
D
R
Y
E
I
D
S
L
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
R
V
E
-
Q
E
W
V
A
I
K
I
I
K
N
K
K
A
F
L
N
Q
A
Q
I
E
V
R
L
L
E
L
M
N
K
H
D
T
E
M
K
Y
Y
I
V
H
L
K
R
H
F
M
F
R
N
H
L
C
L
V
F
E
M
L
S
Y
N
L
Y
D
L
L
R
N
T
N
F
R
G
V
S
L
N
L
T
R
K
F
A
Q
Q
M
C
T
A
L
L
F
L
A
T
P
E
L
S
I
I
H
C
D
L
K
P
E
N
I
L
L
C
N
P
-----------------
K
R
S
A
I
K
I
V
D
F
G
S
S
C
Q
L
G
Q
R
I
Y
Q
Y
I
Q
S
R
F
Y
R
S
P
E
V
L
L
G
M
P
Y
D
L
A
I
D
M
W
S
L
G
C
I
L
V
E
M
H
T
G
E
P
L
F
S
G
A
N
E
V
D
Q
M
N
K
I
V
E
V
L
G
I
P
P
A
H
I
L
D
Q
A
P
K
A
R
K
F
F
E
K
-----------
L
P
D
G
T
W
N
L
K
K
---------
E
Y
K
P
P
G
T
R
K
L
H
N
I
L
G
V
E
T
G
G
P
G
G
R
R
A
G
E
S
G
H
T
V
A
D
Y
L
K
F
K
D
L
I
L
R
M
L
D
Y
D
P
K
T
R
I
Q
P
Y
Y
A
L
Q
H
S
F
F
K
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
66.14
40%
-99
- C3 -
4AZF
2
DYRK2_HUMAN
A:
[57-413]
------------------------------------------------------------------------------------------------------------
E
I
Y
F
L
G
L
N
A
K
K
R
Q
G
M
T
G
G
P
N
--------
N
G
G
Y
D
D
D
Q
G
S
Y
V
Q
V
P
H
D
H
V
A
-
Y
R
Y
E
V
L
K
V
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
H
K
V
-
H
Q
H
V
A
L
K
M
V
R
N
E
K
R
F
H
R
Q
A
A
E
E
I
R
I
L
E
H
L
R
K
Q
D
K
D
N
T
M
N
V
I
H
M
L
E
N
F
T
F
R
N
H
I
C
M
T
F
E
L
L
S
M
N
L
Y
E
L
I
K
K
N
K
F
Q
G
F
S
L
P
L
V
R
K
F
A
H
S
I
L
Q
C
L
D
--
A
L
H
K
N
R
I
I
H
C
D
L
K
P
E
N
I
L
L
K
Q
Q
-----------------
G
R
S
G
I
K
V
I
D
F
G
S
S
C
Y
E
H
Q
R
V
Y
T
Y
I
Q
S
R
F
Y
R
A
P
E
V
I
L
G
A
R
Y
G
M
P
I
D
M
W
S
L
G
C
I
L
A
E
L
L
T
G
Y
P
L
L
P
G
E
D
E
G
D
Q
L
A
C
M
I
E
L
L
G
M
P
S
Q
K
L
L
D
A
S
K
R
A
K
N
F
V
S
S
KGYP
R
Y
C
T
V
T
T
L
S
D
--
V
V
L
----
N
G
---
G
R
S
R
R
-----------
G
K
L
R
G
P
P
E
S
R
E
W
G
N
A
L
K
G
C
D
D
P
L
-
F
L
D
F
L
K
Q
C
L
E
W
D
P
A
V
R
M
T
P
G
Q
A
L
R
H
P
W
L
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
65.42
40%
-96
- C3 -
3KVW
1
DYRK2_HUMAN
A:
[57-413]
------------------------------------------------------------------------------------------------------------
E
I
Y
F
L
G
L
N
A
K
K
R
Q
G
M
T
G
G
P
N
--------
N
G
G
Y
D
D
D
Q
G
S
Y
V
Q
V
P
H
D
H
V
A
-
Y
R
Y
E
V
L
K
V
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
H
K
V
-
H
Q
H
V
A
L
K
M
V
R
N
E
K
R
F
H
R
Q
A
A
E
E
I
R
I
L
E
H
L
R
K
Q
D
K
D
N
T
M
N
V
I
H
M
L
E
N
F
T
F
R
N
H
I
C
M
T
F
E
L
L
S
M
N
L
Y
E
L
I
K
K
N
K
F
Q
G
F
S
L
P
L
V
R
K
F
A
H
S
I
L
Q
C
L
D
--
A
L
H
K
N
R
I
I
H
C
D
L
K
P
E
N
I
L
L
K
Q
Q
-----------------
G
R
S
G
I
K
V
I
D
F
G
S
S
C
Y
E
H
Q
R
V
Y
T
Y
I
Q
S
R
F
Y
R
A
P
E
V
I
L
G
A
R
Y
G
M
P
I
D
M
W
S
L
G
C
I
L
A
E
L
L
T
G
Y
P
L
L
P
G
E
D
E
G
D
Q
L
A
C
M
I
E
L
L
G
M
P
S
Q
K
L
L
D
A
S
K
R
A
K
N
F
V
S
S
KGYP
R
Y
C
T
V
T
T
L
S
D
--
V
V
L
----
N
G
---
G
R
S
R
R
-----------
G
K
L
R
G
P
P
E
S
R
E
W
G
N
A
L
K
G
C
D
D
P
L
-
F
L
D
F
L
K
Q
C
L
E
W
D
P
A
V
R
M
T
P
G
Q
A
L
R
H
P
W
L
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
61.15
30%
-97
- C3 -
3RAW
1
CLK3_HUMAN
A:
[31-369]
------------------------------------------------------------------------------------------------------------------------------------
R
S
V
-----
E
D
D
K
E
G
H
L
V
C
R
I
G
D
W
L
Q
E
R
Y
E
I
V
G
N
L
G
E
G
T
F
G
K
V
V
E
C
L
D
H
A
R
G
K
S
Q
V
A
L
K
I
I
R
N
V
G
K
Y
R
E
A
A
R
L
E
I
N
V
L
K
K
I
K
E
K
D
K
E
N
K
F
L
C
V
L
M
S
D
W
F
N
F
H
G
H
M
C
I
A
F
E
L
L
G
K
N
T
F
E
F
L
K
E
N
N
F
Q
P
Y
P
L
P
H
V
R
H
M
A
Y
Q
L
C
H
A
L
R
F
L
H
E
N
Q
L
T
--
H
T
D
L
K
P
E
N
I
L
F
V
N
S
E
F
E
T
L
Y
N
EHKS
C
E
E
K
S
V
K
N
T
S
I
R
V
A
D
F
G
S
A
T
F
D
H
E
H
H
T
T
I
V
A
T
R
H
Y
R
P
P
E
V
I
L
E
L
G
W
A
Q
P
C
D
V
W
S
I
G
C
I
L
F
E
Y
Y
R
G
F
T
L
F
Q
T
H
E
N
R
E
H
L
V
M
M
E
K
I
L
G
P
I
P
S
H
M
I
H
R
T
R
K
Q
K
Y
F
Y
K
-------------
G
G
L
V
W
D
-
E
N
S
S
D
G
R
Y
V
K
E
N
C
K
P
L
K
S
Y
M
L
Q
D
S
L
--------------------
E
H
V
Q
L
F
D
L
M
R
R
M
L
E
F
D
P
A
Q
R
I
T
L
A
E
A
L
L
H
P
F
F
A
G
L
T
P
E
E
R
S
F
H
T
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
60.77
30%
-96
- C3 -
2WU6
7
CLK3_HUMAN
A:
[31-369]
------------------------------------------------------------------------------------------------------------------------------------
R
S
V
-----
E
D
D
K
E
G
H
L
V
C
R
I
G
D
W
L
Q
E
R
Y
E
I
V
G
N
L
G
E
G
T
F
G
K
V
V
E
C
L
D
H
A
R
G
K
S
Q
V
A
L
K
I
I
R
N
V
G
K
Y
R
E
A
A
R
L
E
I
N
V
L
K
K
I
K
E
K
D
K
E
N
K
F
L
C
V
L
M
S
D
W
F
N
F
H
G
H
M
C
I
A
F
E
L
L
G
K
N
T
F
E
F
L
K
E
N
N
F
Q
P
Y
P
L
P
H
V
R
H
M
A
Y
Q
L
C
H
A
L
R
F
L
H
E
N
Q
L
T
--
H
T
D
L
K
P
E
N
I
L
F
V
N
S
E
F
E
T
L
Y
NEHKS
C
E
E
K
S
V
K
N
T
S
I
R
V
A
D
F
G
S
A
T
F
D
H
E
H
H
T
T
I
V
A
T
R
H
Y
R
P
P
E
V
I
L
E
L
G
W
A
Q
P
C
D
V
W
S
I
G
C
I
L
F
E
Y
Y
R
G
F
T
L
F
Q
T
H
E
N
R
E
H
L
V
M
M
E
K
I
L
G
P
I
P
S
H
M
I
H
R
T
R
K
Q
K
Y
F
Y
K
-------------
G
G
L
V
W
D
-
E
N
S
S
D
G
R
Y
V
K
E
N
C
K
P
L
K
S
Y
M
L
Q
D
S
L
--------------------
E
H
V
Q
L
F
D
L
M
R
R
M
L
E
F
D
P
A
Q
R
I
T
L
A
E
A
L
L
H
P
F
F
A
G
L
T
P
E
E
R
S
F
H
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
60.15
30%
-95
- C3 -
2WU7
1
CLK3_HUMAN
A:
[32-369]
-------------------------------------------------------------------------------------------------------------------------------------
S
V
-----
E
D
D
K
E
G
H
L
V
C
R
I
G
D
W
L
Q
E
R
Y
E
I
V
G
N
L
G
E
G
T
F
G
K
V
V
E
C
L
D
H
A
R
G
K
S
Q
V
A
L
K
I
I
R
N
V
G
K
Y
R
E
A
A
R
L
E
I
N
V
L
K
K
I
K
E
K
D
K
E
N
K
F
L
C
V
L
M
S
D
W
F
N
F
H
G
H
M
C
I
A
F
E
L
L
G
K
N
T
F
E
F
L
K
E
N
N
F
Q
P
Y
P
L
P
H
V
R
H
M
A
Y
Q
L
C
H
A
L
R
F
L
H
E
N
Q
L
T
--
H
T
D
L
K
P
E
N
I
L
F
V
N
S
E
F
E
T
L
Y
NEHKS
C
E
E
K
S
V
K
N
T
S
I
R
V
A
D
F
G
S
A
T
F
D
H
E
H
H
T
T
I
V
A
T
R
H
Y
R
P
P
E
V
I
L
E
L
G
W
A
Q
P
C
D
V
W
S
I
G
C
I
L
F
E
Y
Y
R
G
F
T
L
F
Q
T
H
E
N
R
E
H
L
V
M
M
E
K
I
L
G
P
I
P
S
H
M
I
H
R
T
R
K
Q
K
Y
F
Y
K
-------------
G
G
L
V
W
D
-
E
N
S
S
D
G
R
Y
V
K
E
N
C
K
P
L
K
S
Y
M
L
Q
D
S
L
--------------------
E
H
V
Q
L
F
D
L
M
R
R
M
L
E
F
D
P
A
Q
R
I
T
L
A
E
A
L
L
H
P
F
F
A
G
L
T
P
E
E
R
S
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------