@TOME V2.3
(Nov 2016)
Ref.
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : DYR1B_HUMAN: (2015-10-06 )
MAVPPGHGPFSGFPGPQEHTQVLPDVRLLPRRLPLAFRDATSAPLRKLSVDLIKTYKHINEVYYAKKKRRAQQAPPQDSSNKKEKKVLNHGYDDDNHDYIVRSGERWLERYEIDSLIGKGSFGQVVKAYDHQTQELVAIKIIKNKKAFLNQAQIELRLLELMNQHDTEMKYYIVHLKRHFMFRNHLCLVFELLSYNLYDLLRNTHFRGVSLNLTRKLAQQLCTALLFLATPELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLLGTPYDLAIDMWSLGCILVEMHTGEPLFSGSNEVDQMNRIVEVLGIPPAAMLDQAPKARKYFERLPGGGWTLRRTKELRKDYQGPGTRRLQEVLGVQTGGPGGRRAGEPGHSPADYLRFQDLVLRMLEYEPAARISPLGALQHGFFRRTADEATNTGPAGSSASTSPAPLDTCPSSSTASSISSSGGSSGSSSDNRTYRYSNRYCGGPGPPITDCEMNSPQVPPSQPLRPWAGGDVPHKTHQAPASASSLPGTGAQLPPQPRYLGRPPSPTSPPPPELMDVSLVGGPADCSPPHPAPAPQHPAASALRTRMTGGRPPLPPPDDPATLGPHLGLRGVPQSTAASS
Atome Classification :
(24 SA)
.........10........20........30........40........50........60........70........80........90........100......-.110.......120.......130...-.....140.......150.......160.......170.......180.......190.......200.......210.----......220.......230.......240......--------.250---------------...---------......260....--...270.......280.....-..290.......300.......310.......320.......330.....-..340....-.--..350.......360......--...370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MAVPPGHGPFSGFPG
P
Q
E
H
T
Q
VL
P
D
V
R
L
L
P
R
RL
P
L
A
FRDATSA
P
L
R
K
L
S
V
D
L
I
K
T
Y
K
H
I
N
E
V
Y
Y
A
K
K
K
RRAQQAPPQDSS
N
K
K
E
K
K
V
L
NHGYDDDNH
D
Y
I
VR
S
G
E
R
W
L
-
E
R
Y
E
I
D
S
L
IGKGS
F
G
Q
V
V
K
A
YDH-QT
Q
-
E
L
V
A
I
K
I
I
KN
K
K
A
F
L
N
Q
A
Q
I
E
L
R
L
L
E
L
M
N
QHDTEM
K
Y
Y
I
V
H
L
K
R
H
F
M
F
R
N
H
L
C
L
V
F
E
L
L
S
Y
N
L
Y
D
L
L
RNTHFRGV
S
L
N
L
----
T
R
K
L
A
Q
Q
L
C
T
A
L
L
F
LATP
E
L
S
I
I
H
CDLKPE
N
I
L
L
C--------NP-----------------KR
S
---------
A
I
K
I
V
DFGSS
C
Q
L
--
G
Q
R
I
Y
Q
Y
I
Q
S
R
FYRSP
E
V
L
LG-TPY
D
L
A
I
D
M
WS
L
G
C
I
L
V
E
MHTGEPLFSGS
N
E
V
D
Q
M
N
R
I
V
E
V
LGIP
P
A
A
M
L-DQA
P
K
A
R
K
Y
-
F
--
E
RLPGGG
W
T
L
R
R
T
--
K
E
L
R
K
D--YQGP
G
T
R
R
L
Q
E
V
LGVQTGGPGGRRAGEPGH
S
P
A
D
Y
L
R
F
Q
D
L
V
L
R
M
L
EYEPAARIS
P
L
G
A
L
Q
H
G
F
F
R
R
T
ADEATNTGPAGSSASTSPAPLDTCPSSSTASSISSSGGSSGSSSDN
R
T
Y
R
YSNRYCGGPGPPITDCEMNSPQVPPSQPLRPWAGGDVPHKTHQAPASASSLPGTGAQLPPQPRYLGRPPSPTSPPPPE
L
M
D
V
S
LVGGPADCSPPHPAPAPQH
P
A
A
S
A
L
R
T
RMTGGRPPLPPPDDPATLGPHLGLRGVPQSTAASS
33
PsiBlast_CBE
95.11
83%
-135
- C1 -
2WO6
1
DYR1A_HUMAN
B:
[33-377]
---------------------------------------------------------------------------------------
Y
N
D
G
Y
D
D
D
N
Y
D
Y
I
V
K
N
G
E
K
W
M
-
D
R
Y
E
I
D
S
L
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
R
-
V
E
Q
-
E
W
V
A
I
K
I
I
K
N
K
K
A
F
L
N
Q
A
Q
I
E
V
R
L
L
E
L
M
N
K
H
D
T
E
M
K
Y
Y
I
V
H
L
K
R
H
F
M
F
R
N
H
L
C
L
V
F
E
M
L
S
Y
N
L
Y
D
L
L
R
N
T
N
F
R
G
V
S
L
N
L
----
T
R
K
F
A
Q
Q
M
C
T
A
L
L
F
L
A
T
P
E
L
S
I
I
H
C
D
L
K
P
E
N
I
L
L
C
--------
N
P
-----------------
K
R
S
---------
A
I
K
I
V
D
F
G
S
S
C
Q
L
--
G
Q
R
I
Y
Q
Y
I
Q
S
R
F
Y
R
S
P
E
V
L
L
G
-
M
P
Y
D
L
A
I
D
M
W
S
L
G
C
I
L
V
E
M
H
T
G
E
P
L
F
S
G
A
N
E
V
D
Q
M
N
K
I
V
E
V
L
G
I
P
P
A
H
I
L
-
D
Q
A
P
K
A
R
K
F
-
F
--
E
K
L
P
D
G
T
W
N
L
K
K
-------
R
E
--
Y
K
P
P
G
T
R
K
L
H
N
I
L
G
V
E
T
G
G
P
G
G
R
R
A
G
E
S
G
H
T
V
A
D
Y
L
K
F
K
D
L
I
L
R
M
L
D
Y
D
P
K
T
R
I
Q
P
Y
Y
A
L
Q
H
S
F
F
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
93.42
82%
-131
- C1 -
4AZE
1
DYR1A_HUMAN
A:
[29-378]
-----------------------------------------------------------------------------------
E
R
K
V
Y
N
D
G
Y
D
D
D
N
Y
D
Y
I
V
K
N
G
E
K
W
M
-
D
R
Y
E
I
D
S
L
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
R
-
V
E
Q
-
E
W
V
A
I
K
I
I
K
N
K
K
A
F
L
N
Q
A
Q
I
E
V
R
L
L
E
L
M
N
K
H
D
T
E
M
K
Y
Y
I
V
H
L
K
R
H
F
M
F
R
N
H
L
C
L
V
F
E
M
L
S
Y
N
L
Y
D
L
L
R
N
T
N
F
R
G
V
S
L
N
L
----
T
R
K
F
A
Q
Q
M
C
T
A
L
L
F
L
A
T
P
E
L
S
I
I
H
C
D
L
K
P
E
N
I
L
L
C
--------
N
P
-----------------
K
R
S
---------
A
I
K
I
V
D
F
G
S
S
C
Q
L
--
G
Q
R
I
Y
Q
Y
I
Q
S
R
F
Y
R
S
P
E
V
L
L
G
-
M
P
Y
D
L
A
I
D
M
W
S
L
G
C
I
L
V
E
M
H
T
G
E
P
L
F
S
G
A
N
E
V
D
Q
M
N
K
I
V
E
V
L
G
I
P
P
A
H
I
L
-
D
Q
A
P
K
A
R
K
F
-
F
--
E
K
L
P
D
G
T
W
N
L
K
K
T
--
K
D
G
K
R
E
--
Y
K
P
P
G
T
R
K
L
H
N
I
L
G
V
E
T
G
G
P
G
G
R
R
A
G
E
S
G
H
T
V
A
D
Y
L
K
F
K
D
L
I
L
R
M
L
D
Y
D
P
K
T
R
I
Q
P
Y
Y
A
L
Q
H
S
F
F
K
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
93.31
83%
-130
- C1 -
2WO6
1
DYR1A_HUMAN
A:
[30-378]
------------------------------------------------------------------------------------
R
K
V
Y
N
D
G
Y
D
D
D
N
Y
D
Y
I
V
K
N
G
E
K
W
M
-
D
R
Y
E
I
D
S
L
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
R
-
V
E
Q
-
E
W
V
A
I
K
I
I
K
N
K
K
A
F
L
N
Q
A
Q
I
E
V
R
L
L
E
L
M
N
K
H
D
T
E
M
K
Y
Y
I
V
H
L
K
R
H
F
M
F
R
N
H
L
C
L
V
F
E
M
L
S
Y
N
L
Y
D
L
L
R
N
T
N
F
R
G
V
S
L
N
L
----
T
R
K
F
A
Q
Q
M
C
T
A
L
L
F
L
A
T
P
E
L
S
I
I
H
C
D
L
K
P
E
N
I
L
L
C
--------
N
P
-----------------
K
R
S
---------
A
I
K
I
V
D
F
G
S
S
C
Q
L
--
G
Q
R
I
Y
Q
Y
I
Q
S
R
F
Y
R
S
P
E
V
L
L
G
-
M
P
Y
D
L
A
I
D
M
W
S
L
G
C
I
L
V
E
M
H
T
G
E
P
L
F
S
G
A
N
E
V
D
Q
M
N
K
I
V
E
V
L
G
I
P
P
A
H
I
L
-
D
Q
A
P
K
A
R
K
F
-
F
--
E
K
L
P
D
G
T
W
N
L
K
K
T
------
R
E
--
Y
K
P
P
G
T
R
K
L
H
N
I
L
G
V
E
T
G
G
P
G
G
R
R
A
G
E
S
G
H
T
V
A
D
Y
L
K
F
K
D
L
I
L
R
M
L
D
Y
D
P
K
T
R
I
Q
P
Y
Y
A
L
Q
H
S
F
F
K
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
48
PsiBlast_CBE
92.98
82%
-132
- C1 -
4AZE
1
DYR1A_HUMAN
C:
[29-378]
-----------------------------------------------------------------------------------
E
R
K
V
Y
N
D
G
Y
D
D
D
N
Y
D
Y
I
V
K
N
G
E
K
W
M
-
D
R
Y
E
I
D
S
L
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
R
-
V
E
Q
-
E
W
V
A
I
K
I
I
K
N
K
K
A
F
L
N
Q
A
Q
I
E
V
R
L
L
E
L
M
N
K
H
D
T
E
M
K
Y
Y
I
V
H
L
K
R
H
F
M
F
R
N
H
L
C
L
V
F
E
M
L
S
Y
N
L
Y
D
L
L
R
N
T
N
F
R
G
V
S
L
N
L
----
T
R
K
F
A
Q
Q
M
C
T
A
L
L
F
L
A
T
P
E
L
S
I
I
H
C
D
L
K
P
E
N
I
L
L
C
--------
N
P
-----------------
K
R
S
---------
A
I
K
I
V
D
F
G
S
S
C
Q
L
--
G
Q
R
I
Y
Q
Y
I
Q
S
R
F
Y
R
S
P
E
V
L
L
G
-
M
P
Y
D
L
A
I
D
M
W
S
L
G
C
I
L
V
E
M
H
T
G
E
P
L
F
S
G
A
N
E
V
D
Q
M
N
K
I
V
E
V
L
G
I
P
P
A
H
I
L
-
D
Q
A
P
K
A
R
K
F
-
F
--
E
K
L
P
D
G
T
W
N
L
K
K
T
--
K
D
G
K
R
E
--
Y
K
P
P
G
T
R
K
L
H
N
I
L
G
V
E
T
G
G
P
G
G
R
R
A
G
E
S
G
H
T
V
A
D
Y
L
K
F
K
D
L
I
L
R
M
L
D
Y
D
P
K
T
R
I
Q
P
Y
Y
A
L
Q
H
S
F
F
K
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
49
PsiBlast_CBE
92.20
82%
-132
- C1 -
4AZE
1
DYR1A_HUMAN
B:
[32-378]
--------------------------------------------------------------------------------------
V
Y
N
D
G
Y
D
D
D
N
Y
D
Y
I
V
K
N
G
E
K
W
M
-
D
R
Y
E
I
D
S
L
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
R
-
V
E
Q
-
E
W
V
A
I
K
I
I
K
N
K
K
A
F
L
N
Q
A
Q
I
E
V
R
L
L
E
L
M
N
K
H
D
T
E
M
K
Y
Y
I
V
H
L
K
R
H
F
M
F
R
N
H
L
C
L
V
F
E
M
L
S
Y
N
L
Y
D
L
L
R
N
T
N
F
R
G
V
S
L
N
L
----
T
R
K
F
A
Q
Q
M
C
T
A
L
L
F
L
A
T
P
E
L
S
I
I
H
C
D
L
K
P
E
N
I
L
L
C
--------
N
P
-----------------
K
R
S
---------
A
I
K
I
V
D
F
G
S
S
C
Q
L
--
G
Q
R
I
Y
Q
Y
I
Q
S
R
F
Y
R
S
P
E
V
L
L
G
-
M
P
Y
D
L
A
I
D
M
W
S
L
G
C
I
L
V
E
M
H
T
G
E
P
L
F
S
G
A
N
E
V
D
Q
M
N
K
I
V
E
V
L
G
I
P
P
A
H
I
L
-
D
Q
A
P
K
A
R
K
F
-
F
--
E
K
L
P
D
G
T
W
N
L
K
K
T
--
K
D
G
K
R
E
--
Y
K
P
P
G
T
R
K
L
H
N
I
L
G
V
E
T
G
G
P
G
G
R
R
A
G
E
S
G
H
T
V
A
D
Y
L
K
F
K
D
L
I
L
R
M
L
D
Y
D
P
K
T
R
I
Q
P
Y
Y
A
L
Q
H
S
F
F
K
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
73.49
83%
-90
- C1 -
4YLK
13
DYR1A_HUMAN
A:
[10-357]
-------------------------------------------------------------------------------------
K
V
Y
N
D
G
Y
D
D
D
N
Y
D
Y
I
V
K
N
G
E
K
W
M
-
D
R
Y
E
I
D
S
L
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
R
-
V
E
Q
-
E
W
V
A
I
K
I
I
K
N
K
K
A
F
L
N
Q
A
Q
I
E
V
R
L
L
E
L
M
N
K
H
D
T
E
M
K
Y
Y
I
V
H
L
K
R
H
F
M
F
R
N
H
L
C
L
V
F
E
M
L
S
Y
N
L
Y
D
L
L
R
N
T
N
F
R
G
V
S
L
N
L
----
T
R
K
F
A
Q
Q
M
C
T
A
L
L
F
L
A
T
P
E
L
S
I
I
H
C
D
L
K
P
E
N
I
L
L
C
--------
N
P
-----------------
K
R
S
---------
A
I
K
I
V
D
F
G
S
S
C
Q
L
--
G
Q
R
I
Y
Q
Y
I
Q
S
R
F
Y
R
S
P
E
V
L
L
G
-
M
P
Y
D
L
A
I
D
M
W
S
L
G
C
I
L
V
E
M
H
T
G
E
P
L
F
S
G
A
N
E
V
D
Q
M
N
K
I
V
E
V
L
G
I
P
P
A
H
I
L
-
D
Q
A
P
K
A
R
K
F
-
F
--
E
K
L
P
D
G
T
W
N
L
K
K
--------
E
--
Y
K
P
P
G
T
R
K
L
H
N
I
L
G
V
E
T
G
G
P
G
G
R
R
A
G
E
S
G
H
T
V
A
D
Y
L
K
F
K
D
L
I
L
R
M
L
D
Y
D
P
K
T
R
I
Q
P
Y
Y
A
L
Q
H
S
F
F
K
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
69.98
44%
-111
- C1 -
4AZF
2
DYRK2_HUMAN
A:
[77-413]
----------------------------------------------------------------------------------------
N
G
G
Y
D
D
D
Q
G
S
Y
V
Q
V
P
H
D
H
V
A
-
Y
R
Y
E
V
L
K
V
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
H
-
K
V
H
-
Q
H
V
A
L
K
M
V
R
N
E
K
R
F
H
R
Q
A
A
E
E
I
R
I
L
E
H
L
R
K
Q
D
K
D
N
T
M
N
V
I
H
M
L
E
N
F
T
F
R
N
H
I
C
M
T
F
E
L
L
S
M
N
L
Y
E
L
I
K
K
N
K
F
Q
G
F
S
L
P
L
----
V
R
K
F
A
H
S
I
L
Q
C
L
D
--
A
L
H
K
N
R
I
I
H
C
D
L
K
P
E
N
I
L
L
K
--------
Q
Q
-----------------
G
R
S
---------
G
I
K
V
I
D
F
G
S
S
C
Y
E
--
H
Q
R
V
Y
T
Y
I
Q
S
R
F
Y
R
A
P
E
V
I
L
G
-
A
R
Y
G
M
P
I
D
M
W
S
L
G
C
I
L
A
E
L
L
T
G
Y
P
L
L
P
G
E
D
E
G
D
Q
L
A
C
M
I
E
L
L
G
M
P
S
Q
K
L
L
-
D
A
S
K
R
A
K
N
F
------
V
S
S
K
G
Y
P
R
Y
C
T
--
V
T
T
L
S
D
V
V
L
N
G
G
R
S
R
R
-----
G
K
L
R
G
P
P
E
S
R
E
W
G
N
A
L
K
G
C
D
D
P
L
-
F
L
D
F
L
K
Q
C
L
E
W
D
P
A
V
R
M
T
P
G
Q
A
L
R
H
P
W
L
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
69.28
44%
-109
- C1 -
3KVW
1
DYRK2_HUMAN
A:
[77-413]
----------------------------------------------------------------------------------------
N
G
G
Y
D
D
D
Q
G
S
Y
V
Q
V
P
H
D
H
V
A
-
Y
R
Y
E
V
L
K
V
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
H
-
K
V
H
-
Q
H
V
A
L
K
M
V
R
N
E
K
R
F
H
R
Q
A
A
E
E
I
R
I
L
E
H
L
R
K
Q
D
K
D
N
T
M
N
V
I
H
M
L
E
N
F
T
F
R
N
H
I
C
M
T
F
E
L
L
S
M
N
L
Y
E
L
I
K
K
N
K
F
Q
G
F
S
L
P
L
----
V
R
K
F
A
H
S
I
L
Q
C
L
D
--
A
L
H
K
N
R
I
I
H
C
D
L
K
P
E
N
I
L
L
K
--------
Q
Q
-----------------
G
R
S
---------
G
I
K
V
I
D
F
G
S
S
C
Y
E
--
H
Q
R
V
Y
T
Y
I
Q
S
R
F
Y
R
A
P
E
V
I
L
G
-
A
R
Y
G
M
P
I
D
M
W
S
L
G
C
I
L
A
E
L
L
T
G
Y
P
L
L
P
G
E
D
E
G
D
Q
L
A
C
M
I
E
L
L
G
M
P
S
Q
K
L
L
-
D
A
S
K
R
A
K
N
F
------
V
S
S
K
G
Y
P
R
Y
C
T
--
V
T
T
L
S
D
V
V
L
N
G
G
R
S
R
R
-----
G
K
L
R
G
P
P
E
S
R
E
W
G
N
A
L
K
G
C
D
D
P
L
-
F
L
D
F
L
K
Q
C
L
E
W
D
P
A
V
R
M
T
P
G
Q
A
L
R
H
P
W
L
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
64.54
32%
-120
- C1 -
1Z57
1
CLK1_HUMAN
A:
[5-332]
---------------------------------------------------------------------------------------------------
I
C
Q
S
G
D
V
L
S
-
A
R
Y
E
I
V
D
T
L
G
E
G
A
F
G
K
V
V
E
C
I
D
H
-
K
A
G
G
R
H
V
A
V
K
I
V
K
N
V
D
R
Y
C
E
A
A
R
S
E
I
Q
V
L
E
H
L
N
T
T
D
P
N
S
T
F
R
C
V
Q
M
L
E
W
F
E
H
H
G
H
I
C
I
V
F
E
L
L
G
L
S
T
Y
D
F
I
K
E
N
G
F
L
P
F
R
L
D
H
----
I
R
K
M
A
Y
Q
I
C
K
S
V
N
F
L
H
S
N
K
L
T
--
H
T
D
L
K
P
E
N
I
L
F
V
QS
D
Y
T
E
A
Y
N
---------------------R
D
E
R
T
L
INP
D
I
K
V
V
D
F
G
S
A
T
Y
D
--
D
E
H
H
S
T
L
V
S
T
R
H
Y
R
A
P
E
V
I
L
A
-
L
G
W
S
Q
P
C
D
V
W
S
I
G
C
I
L
I
E
Y
Y
L
G
F
T
V
F
P
T
H
D
S
K
E
H
L
A
M
M
E
R
I
L
G
P
L
P
K
H
M
I
--
Q
K
T
R
K
R
K
Y
-
F
HH
D
R
L
---
D
W
D
E
H
S
S
--
A
---
G
R
--
Y
V
S
R
A
C
K
P
L
K
E
F
M
L
S
Q
---------------
D
V
E
H
E
R
L
F
D
L
I
Q
K
M
L
E
Y
D
P
A
K
R
I
T
L
R
E
A
L
K
H
P
F
F
D
L
L
K
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
64.34
32%
-118
- C1 -
2VAG
1
CLK1_HUMAN
A:
[5-332]
---------------------------------------------------------------------------------------------------
I
C
Q
S
G
D
V
L
S
-
A
R
Y
E
I
V
D
T
L
G
E
G
A
F
G
K
V
V
E
C
I
D
H
-
K
A
G
G
R
H
V
A
V
K
I
V
K
N
V
D
R
Y
C
E
A
A
R
S
E
I
Q
V
L
E
H
L
N
T
T
D
P
N
S
T
F
R
C
V
Q
M
L
E
W
F
E
H
H
G
H
I
C
I
V
F
E
L
L
G
L
S
T
Y
D
F
I
K
E
N
G
F
L
P
F
R
L
D
H
----
I
R
K
M
A
Y
Q
I
C
K
S
V
N
F
L
H
S
N
K
L
T
--
H
T
D
L
K
P
E
N
I
L
F
V
QS
D
Y
T
E
A
Y
N
--------------------
K
R
D
E
R
T
L
INP
D
I
K
V
V
D
F
G
S
A
T
Y
D
--
D
E
H
H
S
T
L
V
S
T
R
H
Y
R
A
P
E
V
I
L
A
-
L
G
W
S
Q
P
C
D
V
W
S
I
G
C
I
L
I
E
Y
Y
L
G
F
T
V
F
P
T
H
D
S
K
E
H
L
A
M
M
E
R
I
L
G
P
L
P
K
H
M
I
--
Q
K
T
R
K
R
K
Y
-
F
HH
D
R
L
---
D
W
D
E
H
S
S
--
A
---
G
R
--
Y
V
S
R
A
C
K
P
L
K
E
F
M
L
S
Q
---------------
D
V
E
H
E
R
L
F
D
L
I
Q
K
M
L
E
Y
D
P
A
K
R
I
T
L
R
E
A
L
K
H
P
F
F
D
L
L
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
51
PsiBlast_CBE
64.09
32%
-101
- C1 -
3NR9
1
CLK2_HUMAN
B:
[16-354]
--------------------------------------------------------------------------------------------
E
D
D
A
E
G
H
L
I
Y
H
V
G
D
W
L
Q
E
R
Y
E
I
V
S
T
L
G
E
G
T
F
G
R
V
V
Q
C
V
D
H
-
R
R
G
G
A
R
V
A
L
K
I
I
K
N
V
E
K
Y
K
E
A
A
R
L
E
I
N
V
L
E
K
I
N
E
K
D
P
D
N
K
N
L
C
V
Q
M
F
D
W
F
D
Y
H
G
H
M
C
I
S
F
E
L
L
G
L
S
T
F
D
F
L
K
D
N
N
Y
L
P
Y
P
I
H
Q
----
V
R
H
M
A
F
Q
L
C
Q
A
V
K
F
L
H
D
N
K
L
T
--
H
T
D
L
K
P
E
N
I
L
F
V
--------
N
S
D
Y
E
L
T
Y
NLEKK
R
D
E
R
S
V
K
S
T
---------
A
V
R
V
V
D
F
G
S
A
T
F
D
--
H
E
H
H
S
T
I
V
S
T
R
H
Y
R
A
P
E
V
I
L
E
-
L
G
W
S
Q
P
C
D
V
W
S
I
G
C
I
I
F
E
Y
Y
V
G
F
T
L
F
Q
T
H
D
N
R
E
H
L
A
M
M
E
R
I
L
G
P
I
P
S
R
M
I
-
R
K
T
R
K
-
Q
K
Y
-
F
--
Y
R
-------------
G
R
L
D
W
D
--
E
N
T
S
A
G
R
Y
V
R
E
-----
N
C
K
P
L
R
R
Y
L
T
S
E
A
---
E
E
H
H
Q
L
F
D
L
I
E
S
M
L
E
Y
E
P
A
K
R
L
T
L
G
E
A
L
Q
H
P
F
F
A
R
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
63.83
32%
-99
- C1 -
3NR9
1
CLK2_HUMAN
A:
[16-356]
--------------------------------------------------------------------------------------------
E
D
D
A
E
G
H
L
I
Y
H
V
G
D
W
L
Q
E
R
Y
E
I
V
S
T
L
G
E
G
T
F
G
R
V
V
Q
C
V
D
H
-
R
R
G
G
A
R
V
A
L
K
I
I
K
N
V
E
K
Y
K
E
A
A
R
L
E
I
N
V
L
E
K
I
N
E
K
D
P
D
N
K
N
L
C
V
Q
M
F
D
W
F
D
Y
H
G
H
M
C
I
S
F
E
L
L
G
L
S
T
F
D
F
L
K
D
N
N
Y
L
P
Y
P
I
H
Q
----
V
R
H
M
A
F
Q
L
C
Q
A
V
K
F
L
H
D
N
K
L
T
--
H
T
D
L
K
P
E
N
I
L
F
V
--------
N
S
D
Y
E
L
TD
E
R
S
V
-------
K
S
T
---------
A
V
R
V
V
D
F
G
S
A
T
F
D
--
H
E
H
H
S
T
I
V
S
T
R
H
Y
R
A
P
E
V
I
L
E
-
L
G
W
S
Q
P
C
D
V
W
S
I
G
C
I
I
F
E
Y
Y
V
G
F
T
L
F
Q
T
H
D
N
R
E
H
L
A
M
M
E
R
I
L
G
P
I
P
S
R
M
I
-
R
K
T
R
K
-
Q
K
Y
-
F
--
Y
R
-------------
G
R
L
D
W
D
--
E
N
T
S
A
G
R
Y
V
R
E
-----
N
C
K
P
L
R
R
Y
L
T
S
E
A
---
E
E
H
H
Q
L
F
D
L
I
E
S
M
L
E
Y
E
P
A
K
R
L
T
L
G
E
A
L
Q
H
P
F
F
A
R
L
R
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
54
PsiBlast_CBE
63.39
31%
-111
- C1 -
2WU7
1
CLK3_HUMAN
A:
[35-369]
--------------------------------------------------------------------------------------------
D
D
K
E
G
H
L
V
C
R
I
G
D
W
L
Q
-
E
R
Y
E
I
V
G
N
L
G
E
G
T
F
G
K
V
V
E
C
L
D
H
A
R
G
K
-
S
Q
V
A
L
K
I
I
R
N
V
G
K
Y
R
E
A
A
R
L
E
I
N
V
L
K
K
I
K
E
K
D
K
E
N
K
F
L
C
V
L
M
S
D
W
F
N
F
H
G
H
M
C
I
A
F
E
L
L
G
K
N
T
F
E
F
L
K
E
N
N
F
Q
P
Y
P
L
P
H
----
V
R
H
M
A
Y
Q
L
C
H
A
L
R
F
L
H
E
N
Q
L
T
--
H
T
D
L
K
P
E
N
I
L
F
V
--------
N
S
E
F
E
T
L
Y
NEHKS
C
E
E
K
S
V
K
N
T
---------
S
I
R
V
A
D
F
G
S
A
T
F
D
--
H
E
H
H
T
T
I
V
A
T
R
H
Y
R
P
P
E
V
I
L
E
-
L
G
W
A
Q
P
C
D
V
W
S
I
G
C
I
L
F
E
Y
Y
R
G
F
T
L
F
Q
T
H
E
N
R
E
H
L
V
M
M
E
K
I
L
G
P
I
P
S
H
M
I
-
H
R
T
R
K
-
Q
K
Y
-
F
--
Y
K
-
G
G
L
V
W
D
E
N
S
S
D
G
R
Y
V
K
E
N
--
C
K
P
L
K
S
Y
M
L
Q
D
S
L
--------------------
E
H
V
Q
L
F
D
L
M
R
R
M
L
E
F
D
P
A
Q
R
I
T
L
A
E
A
L
L
H
P
F
F
A
G
L
T
P
E
E
R
S
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
55
PsiBlast_CBE
63.16
31%
-111
- C1 -
2WU6
7
CLK3_HUMAN
A:
[35-369]
--------------------------------------------------------------------------------------------
D
D
K
E
G
H
L
V
C
R
I
G
D
W
L
Q
-
E
R
Y
E
I
V
G
N
L
G
E
G
T
F
G
K
V
V
E
C
L
D
H
A
R
G
K
-
S
Q
V
A
L
K
I
I
R
N
V
G
K
Y
R
E
A
A
R
L
E
I
N
V
L
K
K
I
K
E
K
D
K
E
N
K
F
L
C
V
L
M
S
D
W
F
N
F
H
G
H
M
C
I
A
F
E
L
L
G
K
N
T
F
E
F
L
K
E
N
N
F
Q
P
Y
P
L
P
H
----
V
R
H
M
A
Y
Q
L
C
H
A
L
R
F
L
H
E
N
Q
L
T
--
H
T
D
L
K
P
E
N
I
L
F
V
--------
N
S
E
F
E
T
L
Y
NEHKS
C
E
E
K
S
V
K
N
T
---------
S
I
R
V
A
D
F
G
S
A
T
F
D
--
H
E
H
H
T
T
I
V
A
T
R
H
Y
R
P
P
E
V
I
L
E
-
L
G
W
A
Q
P
C
D
V
W
S
I
G
C
I
L
F
E
Y
Y
R
G
F
T
L
F
Q
T
H
E
N
R
E
H
L
V
M
M
E
K
I
L
G
P
I
P
S
H
M
I
-
H
R
T
R
K
-
Q
K
Y
-
F
--
Y
K
-
G
G
L
V
W
D
E
N
S
S
D
G
R
Y
V
K
E
N
--
C
K
P
L
K
S
Y
M
L
Q
D
S
L
--------------------
E
H
V
Q
L
F
D
L
M
R
R
M
L
E
F
D
P
A
Q
R
I
T
L
A
E
A
L
L
H
P
F
F
A
G
L
T
P
E
E
R
S
F
H
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
52
PsiBlast_CBE
63.13
31%
-110
- C1 -
3RAW
1
CLK3_HUMAN
B:
[35-369]
--------------------------------------------------------------------------------------------
D
D
K
E
G
H
L
V
C
R
I
G
D
W
L
Q
-
E
R
Y
E
I
V
G
N
L
G
E
G
T
F
G
K
V
V
E
C
L
D
H
A
R
G
K
-
S
Q
V
A
L
K
I
I
R
N
V
G
K
Y
R
E
A
A
R
L
E
I
N
V
L
K
K
I
K
E
K
D
K
E
N
K
F
L
C
V
L
M
S
D
W
F
N
F
H
G
H
M
C
I
A
F
E
L
L
G
K
N
T
F
E
F
L
K
E
N
N
F
Q
P
Y
P
L
P
H
----
V
R
H
M
A
Y
Q
L
C
H
A
L
R
F
L
H
E
N
Q
L
T
--
H
T
D
L
K
P
E
N
I
L
F
V
--------
N
S
E
F
E
T
L
Y
N
EHKS
C
E
E
K
S
V
K
N
T
---------
S
I
R
V
A
D
F
G
S
A
T
F
D
--
H
E
H
H
T
T
I
V
A
T
R
H
Y
R
P
P
E
V
I
L
E
-
L
G
W
A
Q
P
C
D
V
W
S
I
G
C
I
L
F
E
Y
Y
R
G
F
T
L
F
Q
T
H
E
N
R
E
H
L
V
M
M
E
K
I
L
G
P
I
P
S
H
M
I
-
H
R
T
R
K
-
Q
K
Y
-
F
--
Y
K
-
G
G
L
V
W
D
E
N
S
S
D
G
R
Y
V
K
E
N
--
C
K
P
L
K
S
Y
M
L
Q
D
S
L
--------------------
E
H
V
Q
L
F
D
L
M
R
R
M
L
E
F
D
P
A
Q
R
I
T
L
A
E
A
L
L
H
P
F
F
A
G
L
T
P
E
E
R
S
F
H
T
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
50
PsiBlast_CBE
63.03
32%
-100
- C1 -
3NR9
1
CLK2_HUMAN
C:
[16-355]
--------------------------------------------------------------------------------------------
E
D
D
A
E
G
H
L
I
Y
H
V
G
D
W
L
Q
E
R
Y
E
I
V
S
T
L
G
E
G
T
F
G
R
V
V
Q
C
V
D
H
-
R
R
G
G
A
R
V
A
L
K
I
I
K
N
V
E
K
Y
K
E
A
A
R
L
E
I
N
V
L
E
K
I
N
E
K
D
P
D
N
K
N
L
C
V
Q
M
F
D
W
F
D
Y
H
G
H
M
C
I
S
F
E
L
L
G
L
S
T
F
D
F
L
K
D
N
N
Y
L
P
Y
P
I
H
Q
----
V
R
H
M
A
F
Q
L
C
Q
A
V
K
F
L
H
D
N
K
L
T
--
H
T
D
L
K
P
E
N
I
L
F
V
--------
N
S
DYELTYNLEKKRDERSV
K
S
T
---------
A
V
R
V
V
D
F
G
S
A
T
F
D
--
H
E
H
H
S
T
I
V
S
T
R
H
Y
R
A
P
E
V
I
L
E
-
L
G
W
S
Q
P
C
D
V
W
S
I
G
C
I
I
F
E
Y
Y
V
G
F
T
L
F
Q
T
H
D
N
R
E
H
L
A
M
M
E
R
I
L
G
P
I
P
S
R
M
I
-
R
K
T
R
K
-
Q
K
Y
-
F
--
Y
R
-------------
G
R
L
D
W
D
--
E
N
T
S
A
G
R
Y
V
R
E
-----
N
C
K
P
L
R
R
Y
L
T
S
E
A
---
E
E
H
H
Q
L
F
D
L
I
E
S
M
L
E
Y
E
P
A
K
R
L
T
L
G
E
A
L
Q
H
P
F
F
A
R
L
R
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
53
PsiBlast_CBE
62.06
31%
-110
- C1 -
3RAW
1
CLK3_HUMAN
A:
[35-369]
--------------------------------------------------------------------------------------------
D
D
K
E
G
H
L
V
C
R
I
G
D
W
L
Q
-
E
R
Y
E
I
V
G
N
L
G
E
G
T
F
G
K
V
V
E
C
L
D
H
A
R
G
K
-
S
Q
V
A
L
K
I
I
R
N
V
G
K
Y
R
E
A
A
R
L
E
I
N
V
L
K
K
I
K
E
K
D
K
E
N
K
F
L
C
V
L
M
S
D
W
F
N
F
H
G
H
M
C
I
A
F
E
L
L
G
K
N
T
F
E
F
L
K
E
N
N
F
Q
P
Y
P
L
P
H
----
V
R
H
M
A
Y
Q
L
C
H
A
L
R
F
L
H
E
N
Q
L
T
--
H
T
D
L
K
P
E
N
I
L
F
V
--------
N
S
E
F
E
T
L
Y
N
EHKS
C
E
E
K
S
V
K
N
T
---------
S
I
R
V
A
D
F
G
S
A
T
F
D
--
H
E
H
H
T
T
I
V
A
T
R
H
Y
R
P
P
E
V
I
L
E
-
L
G
W
A
Q
P
C
D
V
W
S
I
G
C
I
L
F
E
Y
Y
R
G
F
T
L
F
Q
T
H
E
N
R
E
H
L
V
M
M
E
K
I
L
G
P
I
P
S
H
M
I
-
H
R
T
R
K
-
Q
K
Y
-
F
--
Y
K
-
G
G
L
V
W
D
E
N
S
S
D
G
R
Y
V
K
E
N
--
C
K
P
L
K
S
Y
M
L
Q
D
S
L
--------------------
E
H
V
Q
L
F
D
L
M
R
R
M
L
E
F
D
P
A
Q
R
I
T
L
A
E
A
L
L
H
P
F
F
A
G
L
T
P
E
E
R
S
F
H
T
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
69
PsiBlast_CBE
50.24
31%
-106
- C1 -
1PYX
1
GSK3B_HUMAN
A:
[58-347]
---------------------------------------------------------------------------------------------------------------
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
C
-
D
S
G
-
E
L
V
A
I
K
K
V
L
Q
D
K
R
F
K
N
R
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
L
R
Y
F
F
Y
S
S
-----
E
V
Y
L
N
---
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
--
H
Y
S
R
A
K
Q
T
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
--
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
---------
D
P
-----------------
D
T
A
---------
V
L
K
L
C
D
F
G
S
A
K
Q
L
V
R
G
E
P
N
V
S
Y
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
G
Q
P
I
F
P
G
D
S
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
R
E
Q
I
R
E
M
N
P
----
F
K
F
--
P
Q
I
K
A
H
P
W
----
T
--
K
V
F
R
-------
P
R
T
---------------------
P
P
E
A
I
A
-------
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
D
P
N
V
K
L
P
N
G
R
D
T
P
A
L
F
N
F
T
T
Q
E
L
S
S
N
P
P
L
A
T
I
L
I
P
P
H
A
R
I
Q
A
--------------------------------------------------------------------------------------------------------------------------------------------------------
68
PsiBlast_CBE
49.81
31%
-105
- C1 -
1PYX
1
GSK3B_HUMAN
B:
[58-347]
---------------------------------------------------------------------------------------------------------------
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
C
-
D
S
G
-
E
L
V
A
I
K
K
V
L
Q
D
K
R
F
K
N
R
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
L
R
Y
F
F
Y
S
S
-----
E
V
Y
L
N
---
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
--
H
Y
S
R
A
K
Q
T
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
--
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
---------
D
P
-----------------
D
T
A
---------
V
L
K
L
C
D
F
G
S
A
K
Q
L
V
R
G
E
P
N
V
S
Y
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
G
Q
P
I
F
P
G
D
S
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
R
E
Q
I
R
E
M
------
F
K
F
--
P
Q
I
K
A
H
P
W
----
T
--
K
V
F
R
-------
P
R
T
---------------------
P
P
E
A
I
A
-------
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
D
P
N
V
K
L
P
N
G
R
D
T
P
A
L
F
N
F
T
T
Q
E
L
S
S
N
P
P
L
A
T
I
L
I
P
P
H
A
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------
85
PsiBlast_CBE
49.26
31%
-103
- C1 -
2JLD
1
GSK3B_HUMAN
B:
[56-345]
---------------------------------------------------------------------------------------------------------------
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
C
-
D
S
G
-
E
L
V
A
I
K
K
V
L
Q
D
K
R
F
K
N
R
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
L
R
Y
F
F
Y
S
S
G
E
K
K
D
E
V
Y
L
N
---
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
--
H
Y
S
R
A
K
Q
T
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
--
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
---------
D
P
-----------------
D
T
A
---------
V
L
K
L
C
D
F
G
S
A
K
Q
L
V
R
G
E
P
N
V
S
Y
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
G
Q
P
I
F
P
G
D
S
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
R
E
Q
I
R
E
M
N
P
N
Y
T
E
F
-
F
--
P
Q
I
K
A
H
P
W
----
T
--
K
V
F
R
-------
P
R
T
---------------------
P
P
E
A
I
A
-------
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
D
P
N
V
K
L
P
N
G
R
D
T
P
A
L
F
N
F
T
T
Q
E
L
S
S
N
P
P
L
A
T
I
L
I
P
P
H
A
R
I
----------------------------------------------------------------------------------------------------------------------------------------------------------
89
PsiBlast_CBE
48.12
31%
-98
- C1 -
1J1B
1
GSK3B_HUMAN
B:
[56-345]
---------------------------------------------------------------------------------------------------------------
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
C
-
D
S
G
-
E
L
V
A
I
K
K
V
L
Q
D
K
R
F
K
N
R
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
L
R
Y
F
F
Y
S
S
G
E
K
K
D
E
V
Y
L
N
---
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
--
H
Y
S
R
A
K
Q
T
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
--
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
---------
D
P
-----------------
D
T
A
---------
V
L
K
L
C
D
F
G
S
A
K
Q
L
V
R
G
E
P
N
V
S
Y
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
G
Q
P
I
F
P
G
D
S
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
R
E
Q
I
R
E
M
N
P
N
Y
T
E
F
K
F
--
P
Q
I
K
A
H
P
W
----
T
--
K
V
F
R
-------
P
R
T
---------------------
P
P
E
A
I
A
-------
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
D
P
N
V
K
L
P
N
G
R
D
T
P
A
L
F
N
F
T
T
Q
E
L
S
S
N
P
P
L
A
T
I
L
I
P
P
H
A
R
I
Q
A
--------------------------------------------------------------------------------------------------------------------------------------------------------
90
PsiBlast_CBE
47.83
31%
-100
- C1 -
1J1B
1
GSK3B_HUMAN
A:
[56-345]
---------------------------------------------------------------------------------------------------------------
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
C
-
D
S
G
-
E
L
V
A
I
K
K
V
L
Q
D
K
R
F
K
N
R
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
L
R
Y
F
F
Y
S
S
G
E
K
K
D
E
V
Y
L
N
---
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
--
H
Y
S
R
A
K
Q
T
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
--
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
---------
D
P
-----------------
D
T
A
---------
V
L
K
L
C
D
F
G
S
A
K
Q
L
V
R
G
E
P
N
V
S
Y
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
G
Q
P
I
F
P
G
D
S
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
R
E
Q
I
R
E
M
N
P
N
Y
T
E
F
K
F
--
P
Q
I
K
A
H
P
W
----
T
--
K
V
F
R
-------
P
R
T
---------------------
P
P
E
A
I
A
-------
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
D
P
N
V
K
L
P
N
G
R
D
T
P
A
L
F
N
F
T
T
Q
E
L
S
S
N
P
P
L
A
T
I
L
I
P
P
H
A
R
I
Q
A
A
A
------------------------------------------------------------------------------------------------------------------------------------------------------
66
PsiBlast_CBE
46.08
31%
-103
- C1 -
3DU8
1
GSK3B_HUMAN
B:
[58-347]
---------------------------------------------------------------------------------------------------------------
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
C
-
D
S
G
-
E
L
V
A
I
K
K
V
L
Q
D
K
R
F
K
N
R
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
L
R
Y
F
F
Y
S
S
------
V
Y
L
N
---
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
--
H
Y
S
R
A
K
Q
T
L
PVIY
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
--
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
---------
D
P
-----------------
D
T
A
---------
V
L
K
L
C
D
F
G
S
A
K
Q
L
VR
G
E
P
N
V
S
Y
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
G
Q
P
I
F
P
G
D
S
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
R
E
Q
I
R
E
M
N
P
------
F
--
P
Q
I
K
A
H
P
W
----
T
--
K
V
F
R
-------
P
R
T
---------------------
P
P
E
A
I
A
-------
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
D
P
N
V
K
L
P
N
G
R
D
T
P
A
L
F
N
F
T
T
Q
E
L
S
S
N
P
P
L
A
T
I
L
I
P
P
H
A
R
I
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------
67
PsiBlast_CBE
45.57
31%
-101
- C1 -
3DU8
1
GSK3B_HUMAN
A:
[58-347]
---------------------------------------------------------------------------------------------------------------
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
C
-
D
S
G
-
E
L
V
A
I
K
K
V
L
Q
D
K
R
F
K
N
R
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
L
R
Y
F
F
Y
S
S
------
V
Y
L
N
---
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
--
H
Y
S
R
A
K
Q
T
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
--
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
---------
D
P
-----------------
D
T
A
---------
V
L
K
L
C
D
F
G
S
A
K
Q
L
V
R
G
E
P
N
V
S
Y
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
G
Q
P
I
F
P
G
D
S
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
R
E
Q
I
R
E
M
N
P
------
F
--
P
Q
I
K
A
H
P
W
----
T
--
K
V
F
R
-------
P
R
T
---------------------
P
P
E
A
I
A
-------
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
D
P
N
V
K
L
P
N
G
R
D
T
P
A
L
F
N
F
T
T
Q
E
L
S
S
N
P
P
L
A
T
I
L
I
P
P
H
A
------------------------------------------------------------------------------------------------------------------------------------------------------------