@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : DYRK2_HUMAN: (2015-10-06 )
MLTRKPSAAAPAAYPTGRGGDSAVRQLQASPGLGAGATRSGVGTGPPSPIALPPLRASNAAAAAHTIGGSKHTMNDHLHVGSHAHGQIQVQQLFEDNSNKRTVLTTQPNGLTTVGKTGLPVVPERQLDSIHRRQGSSTSLKSMEGMGKVKATPMTPEQAMKQYMQKLTAFEHHEIFSYPEIYFLGLNAKKRQGMTGGPNNGGYDDDQGSYVQVPHDHVAYRYEVLKVIGKGSFGQVVKAYDHKVHQHVALKMVRNEKRFHRQAAEEIRILEHLRKQDKDNTMNVIHMLENFTFRNHICMTFELLSMNLYELIKKNKFQGFSLPLVRKFAHSILQCLDALHKNRIIHCDLKPENILLKQQGRSGIKVIDFGSSCYEHQRVYTYIQSRFYRAPEVILGARYGMPIDMWSLGCILAELLTGYPLLPGEDEGDQLACMIELLGMPSQKLLDASKRAKNFVSSKGYPRYCTVTTLSDGSVVLNGGRSRRGKLRGPPESREWGNALKGCDDPLFLDFLKQCLEWDPAVRMTPGQALRHPWLRRRLPKPPTGEKTSVKRITESTGAITSISKLPPPSSSASKLRTNLAQMTDANGNIQQRTVLPKLVS
Atome Classification :
(23 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240-.-.-.-....250....----...260.......270.......280-------.......290..-----.----....300.......310...-....320.......330.......340..-.......350....-----------------.----..360---------------------..--------------.......370...-.-.--..380.......390.....-..400.......410.......420......-------.430.......440.......--450-........460........470.......480......-.490-........500---------------...-------.--------.....510.......520.......530.......540.......550.......560.......570.......580.......590.......600
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MLTRKPSAAAPAAYPTGRG
G
D
S
A
V
R
Q
L
QASPGLGAGATRSGVGTGPPSPIALPPLRASNAAA
A
A
HTIGGSKHTMNDHLHVGSHAH
G
Q
I
Q
V
Q
Q
L
F
EDNSN
K
R
T
V
L
TTQPNG
L
T
TVGKTGLPVV
P
E
R
Q
L
D
S
I
H
R
RQGSSTS
L
K
S
M
EGMGKVKATPM
T
P
E
Q
A
M
K
Q
Y
M
Q
K
L
T
A
F
E
HHEIFSYP
E
I
Y
F
L
GLNAKKRQGMTGGPNNGGYDDDQG
S
Y
V
QVP
H
D
H
V
A
Y
R
Y
E
V
L
K
V
IGKGS
F
G
Q
V
V
K
A
Y
D
H
-
K
-
V
-
H
-
Q
H
V
A
L
K
M
V
R
N
E
----
K
R
F
H
R
Q
A
A
E
E
I
R
I
L
E
H
L
R
KQDKDN
T
M
-------
N
V
I
H
M
L
E
NFTFR-----N----
H
I
C
M
T
F
E
L
L
S
M
N
L
Y
E
L
I
K
KN-KFQGFS
L
P
L
V
R
K
F
A
H
S
I
L
Q
C
L
D
A
L
H--KN-
R
I
I
H
C
DLKPE
N
I
L
L
-----------------K----QQG-----------------------RS--------------G
I
K
V
I
DFGS
S
C
Y
E
-
H
-
Q
--
R
V
Y
T
Y
I
Q
S
R
FYRA
P
E
V
I
L
GA-RYGMP
I
D
M
W
S
L
G
C
I
L
A
E
L
LTGYPLLPGEDEG-------
D
Q
L
A
C
M
I
E
L
LGM
P
S
Q
K
L
L
D
A
S
--
K
R
--
A
K
N
F
V
SSKGY-P
R
Y
C
T
V
T
TLSD
G
S
V
V
L
NGGRSRRGKLR-GPP--E
S
R
E
W
G
N
AL-----------------KGC-------D--------
D
P
L
F
L
D
F
L
K
Q
C
LEWDPAVRMTP
G
Q
A
L
R
H
P
W
L
R
RRLPKPPTGEK
T
S
V
K
R
I
T
ESTGAITSISKLPPPSS
S
A
S
K
L
R
T
N
L
A
Q
MTDANGNI
Q
Q
RTVL
P
K
LVS
2
PsiBlast_PDB
94.87
98%
-114
- C1 -
4AZF
2
DYRK2_HUMAN
A:
[20-413]
----------------------------------------------------------------------------------------------------------------------------------------------
F
Q
S
M
G
K
V
K
A
T
P
M
T
P
E
Q
A
M
K
Q
Y
M
Q
K
L
T
A
F
E
H
H
E
I
F
S
Y
P
E
I
Y
F
L
G
L
N
A
K
K
R
Q
G
M
T
G
G
P
N
N
G
G
Y
D
D
D
Q
G
S
Y
V
Q
V
P
H
D
H
V
A
Y
R
Y
E
V
L
K
V
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
H
-
K
-
V
-
H
-
Q
H
V
A
L
K
M
V
R
N
E
----
K
R
F
H
R
Q
A
A
E
E
I
R
I
L
E
H
L
R
K
Q
D
K
D
N
T
M
-------
N
V
I
H
M
L
E
N
F
T
F
R
-----
N
----
H
I
C
M
T
F
E
L
L
S
M
N
L
Y
E
L
I
K
K
N
-
K
F
Q
G
F
S
L
P
L
V
R
K
F
A
H
S
I
L
Q
C
L
D
A
L
H
--
K
N
-
R
I
I
H
C
D
L
K
P
E
N
I
L
L
-----------------
K
----
Q
Q
G
-----------------------
R
S
--------------
G
I
K
V
I
D
F
G
S
S
C
Y
E
-
H
-
Q
--
R
V
Y
T
Y
I
Q
S
R
F
Y
R
A
P
E
V
I
L
G
A
-
R
Y
G
M
P
I
D
M
W
S
L
G
C
I
L
A
E
L
L
T
G
Y
P
L
L
P
G
E
D
E
G
-------
D
Q
L
A
C
M
I
E
L
L
G
M
P
S
Q
K
L
L
D
A
S
--
K
R
--
A
K
N
F
V
S
S
K
G
Y
-
P
R
Y
C
T
V
T
T
L
S
D
--
V
V
L
N
G
G
R
S
R
R
G
K
L
R
-
G
P
P
--
E
S
R
E
W
G
N
A
L
-----------------
K
G
C
-------
D
--------
D
P
L
F
L
D
F
L
K
Q
C
L
E
W
D
P
A
V
R
M
T
P
G
Q
A
L
R
H
P
W
L
R
-----------------------------------------------------------------
1
PsiBlast_PDB
93.69
98%
-114
- C1 -
3KVW
1
DYRK2_HUMAN
A:
[20-413]
----------------------------------------------------------------------------------------------------------------------------------------------
F
Q
S
M
G
K
V
K
A
T
P
M
T
P
E
Q
A
M
K
Q
Y
M
Q
K
L
T
A
F
E
H
H
E
I
F
S
Y
P
E
I
Y
F
L
G
L
N
A
K
K
R
Q
G
M
T
G
G
P
N
N
G
G
Y
D
D
D
Q
G
S
Y
V
Q
V
P
H
D
H
V
A
Y
R
Y
E
V
L
K
V
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
H
-
K
-
V
-
H
-
Q
H
V
A
L
K
M
V
R
N
E
----
K
R
F
H
R
Q
A
A
E
E
I
R
I
L
E
H
L
R
K
Q
D
K
D
N
T
M
-------
N
V
I
H
M
L
E
N
F
T
F
R
-----
N
----
H
I
C
M
T
F
E
L
L
S
M
N
L
Y
E
L
I
K
K
N
-
K
F
Q
G
F
S
L
P
L
V
R
K
F
A
H
S
I
L
Q
C
L
D
A
L
H
--
K
N
-
R
I
I
H
C
D
L
K
P
E
N
I
L
L
-----------------
K
----
Q
Q
G
-----------------------
R
S
--------------
G
I
K
V
I
D
F
G
S
S
C
Y
E
-
H
-
Q
--
R
V
Y
T
Y
I
Q
S
R
F
Y
R
A
P
E
V
I
L
G
A
-
R
Y
G
M
P
I
D
M
W
S
L
G
C
I
L
A
E
L
L
T
G
Y
P
L
L
P
G
E
D
E
G
-------
D
Q
L
A
C
M
I
E
L
L
G
M
P
S
Q
K
L
L
D
A
S
--
K
R
--
A
K
N
F
V
S
S
K
G
Y
-
P
R
Y
C
T
V
T
T
L
S
D
--
V
V
L
N
G
G
R
S
R
R
G
K
L
R
-
G
P
P
--
E
S
R
E
W
G
N
A
L
-----------------
K
G
C
-------
D
--------
D
P
L
F
L
D
F
L
K
Q
C
L
E
W
D
P
A
V
R
M
T
P
G
Q
A
L
R
H
P
W
L
R
-----------------------------------------------------------------
71
HHSearch
93.25
99%
-112
- C1 -
3KVW
1
DYRK2_HUMAN
A:
[17-413]
-------------------------------------------------------------------------------------------------------------------------------------------
N
L
Y
F
Q
S
M
G
K
V
K
A
T
P
M
T
P
E
Q
A
M
K
Q
Y
M
Q
K
L
T
A
F
E
H
H
E
I
F
S
Y
P
E
I
Y
F
L
G
L
N
A
K
K
R
Q
G
M
T
G
G
P
N
N
G
G
Y
D
D
D
Q
G
S
Y
V
Q
V
P
H
D
H
V
A
Y
R
Y
E
V
L
K
V
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
H
-
K
-
V
-
H
-
Q
H
V
A
L
K
M
V
R
N
E
----
K
R
F
H
R
Q
A
A
E
E
I
R
I
L
E
H
L
R
K
Q
D
K
D
N
T
M
-------
N
V
I
H
M
L
E
N
F
T
F
R
-----
N
----
H
I
C
M
T
F
E
L
L
S
M
N
L
Y
E
L
I
K
K
N
-
K
F
Q
G
F
S
L
P
L
V
R
K
F
A
H
S
I
L
Q
C
L
D
A
L
H
--
K
N
-
R
I
I
H
C
D
L
K
P
E
N
I
L
L
-----------------
K
----
Q
Q
G
-----------------------
R
S
--------------
G
I
K
V
I
D
F
G
S
S
C
Y
E
-
H
-
Q
--
R
V
Y
T
Y
I
Q
S
R
F
Y
R
A
P
E
V
I
L
G
A
-
R
Y
G
M
P
I
D
M
W
S
L
G
C
I
L
A
E
L
L
T
G
Y
P
L
L
P
G
E
D
E
G
-------
D
Q
L
A
C
M
I
E
L
L
G
M
P
S
Q
K
L
L
D
A
S
--
K
R
--
A
K
N
F
V
S
S
K
G
Y
-
P
R
Y
C
T
V
T
T
L
S
D
--
V
V
L
N
G
G
R
S
R
R
G
K
L
R
-
G
P
P
--
E
S
R
E
W
G
N
A
L
-----------------
K
G
C
-------
D
--------
D
P
L
F
L
D
F
L
K
Q
C
L
E
W
D
P
A
V
R
M
T
P
G
Q
A
L
R
H
P
W
L
R
-----------------------------------------------------------------
32
PsiBlast_CBE
69.49
43%
-116
- C1 -
2WO6
1
DYR1A_HUMAN
B:
[55-377]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
Y
E
I
D
S
L
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
R
-
V
-
E
-
Q
-
E
W
V
A
I
K
I
I
K
N
K
----
K
A
F
L
N
Q
A
Q
I
E
V
R
L
L
E
L
M
N
K
H
D
T
E
M
K
Y
-------
Y
I
V
H
L
K
R
H
F
M
F
R
-----
N
----
H
L
C
L
V
F
E
M
L
S
Y
N
L
Y
D
L
L
R
N
T
-
N
F
R
G
V
S
L
N
L
T
R
K
F
A
Q
Q
M
C
T
A
L
L
F
L
A
TP
E
L
-
S
I
I
H
C
D
L
K
P
E
N
I
L
L
-----------------
C
----
N
P
K
-----------------------
R
S
--------------
A
I
K
I
V
D
F
G
S
S
C
Q
L
-
G
-
Q
--
R
I
Y
Q
Y
I
Q
S
R
F
Y
R
S
P
E
V
L
L
G
M
-
P
Y
D
L
A
I
D
M
W
S
L
G
C
I
L
V
E
M
H
T
G
E
P
L
F
S
G
A
N
E
V
-------
D
Q
M
N
K
I
V
E
V
L
G
I
P
P
A
H
I
L
D
Q
A
--
P
K
--
A
R
K
F
F
E
K
------------
L
P
D
G
T
--
W
N
L
K
K
-----
R
E
Y
K
P
P
--
G
T
R
K
L
H
N
I
L
GVETGGPGGRRAGESGH
T
V
A
-------
D
--------
Y
L
K
F
K
D
L
I
L
R
M
L
D
Y
D
P
K
T
R
I
Q
P
Y
Y
A
L
Q
H
S
F
F
K
-----------------------------------------------------------------
15
PsiBlast_PDB
67.93
42%
-115
- C1 -
4AZE
1
DYR1A_HUMAN
A:
[55-378]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
Y
E
I
D
S
L
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
R
-
V
-
E
-
Q
-
E
W
V
A
I
K
I
I
K
N
K
----
K
A
F
L
N
Q
A
Q
I
E
V
R
L
L
E
L
M
N
K
H
D
T
E
M
K
Y
-------
Y
I
V
H
L
K
R
H
F
M
F
R
-----
N
----
H
L
C
L
V
F
E
M
L
S
Y
N
L
Y
D
L
L
R
N
T
-
N
F
R
G
V
S
L
N
L
T
R
K
F
A
Q
Q
M
C
T
A
L
L
F
L
A
TP
E
L
-
S
I
I
H
C
D
L
K
P
E
N
I
L
L
-----------------
C
----
N
P
K
-----------------------
R
S
--------------
A
I
K
I
V
D
F
G
S
S
C
Q
L
-
G
-
Q
--
R
I
Y
Q
Y
I
Q
S
R
F
Y
R
S
P
E
V
L
L
G
M
-
P
Y
D
L
A
I
D
M
W
S
L
G
C
I
L
V
E
M
H
T
G
E
P
L
F
S
G
A
N
E
V
-------
D
Q
M
N
K
I
V
E
V
L
G
I
P
P
A
H
I
L
D
Q
A
--
P
K
--
A
R
K
F
F
E
K
------------
L
P
D
G
T
--
W
N
L
K
K
T
K
D
G
K
R
E
Y
K
P
P
--
G
T
R
K
L
H
N
I
L
GVETGGPGGRRAGESG
H
T
V
A
-------
D
--------
Y
L
K
F
K
D
L
I
L
R
M
L
D
Y
D
P
K
T
R
I
Q
P
Y
Y
A
L
Q
H
S
F
F
K
K
----------------------------------------------------------------
7
PsiBlast_PDB
66.40
43%
-113
- C1 -
2WO6
1
DYR1A_HUMAN
A:
[55-378]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
Y
E
I
D
S
L
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
R
-
V
-
E
-
Q
-
E
W
V
A
I
K
I
I
K
N
K
----
K
A
F
L
N
Q
A
Q
I
E
V
R
L
L
E
L
M
N
K
H
D
T
E
M
K
Y
-------
Y
I
V
H
L
K
R
H
F
M
F
R
-----
N
----
H
L
C
L
V
F
E
M
L
S
Y
N
L
Y
D
L
L
R
N
T
-
N
F
R
G
V
S
L
N
L
T
R
K
F
A
Q
Q
M
C
T
A
L
L
F
L
A
TP
E
L
-
S
I
I
H
C
D
L
K
P
E
N
I
L
L
-----------------
C
----
N
P
K
-----------------------
R
S
--------------
A
I
K
I
V
D
F
G
S
S
C
Q
L
-
G
-
Q
--
R
I
Y
Q
Y
I
Q
S
R
F
Y
R
S
P
E
V
L
L
G
M
-
P
Y
D
L
A
I
D
M
W
S
L
G
C
I
L
V
E
M
H
T
G
E
P
L
F
S
G
A
N
E
V
-------
D
Q
M
N
K
I
V
E
V
L
G
I
P
P
A
H
I
L
D
Q
A
--
P
K
--
A
R
K
F
F
E
K
------------
L
P
D
G
T
--
W
N
L
K
K
T
----
R
E
Y
K
P
P
--
G
T
R
K
L
H
N
I
L
GVETGGPGGRRAGESGH
T
V
A
-------
D
--------
Y
L
K
F
K
D
L
I
L
R
M
L
D
Y
D
P
K
T
R
I
Q
P
Y
Y
A
L
Q
H
S
F
F
K
K
----------------------------------------------------------------
18
PsiBlast_PDB
61.16
32%
-104
- C1 -
3NR9
1
CLK2_HUMAN
A:
[17-356]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
A
E
G
H
L
I
Y
H
V
G
D
W
L
Q
E
R
Y
E
I
V
S
T
L
G
E
G
T
F
G
R
V
V
Q
C
V
D
H
-
R
-
R
-
G
G
A
R
V
A
L
K
I
I
K
N
V
----
E
K
Y
K
E
A
A
R
L
E
I
N
V
L
E
K
I
N
E
K
D
P
D
N
K
N
-------
L
C
V
Q
M
F
D
W
F
D
Y
H
-----
G
----
H
M
C
I
S
F
E
L
L
G
L
S
T
F
D
F
L
K
D
N
-
N
Y
L
P
Y
P
I
H
Q
V
R
H
M
A
F
Q
L
C
Q
A
V
K
F
L
H
--
D
N
-
K
L
T
H
T
D
L
K
P
E
N
I
L
F
VNS
D
Y
E
L
T---------------
D
E
-----------------------
R
S
V
KST----------
A
V
R
V
V
D
F
G
S
A
T
F
D
-
H
-
E
--
H
H
S
T
I
V
S
T
R
H
Y
R
A
P
E
V
I
L
E
L
-
G
W
S
Q
P
C
D
V
W
S
I
G
C
I
I
F
E
Y
Y
V
G
F
T
L
F
Q
T
H
D
N
R
-------
E
H
L
A
M
M
E
R
I
L
G
P
I
P
S
R
M
I
R
K
T
--
R
K
--
Q
K
Y
F
Y
R
G
-----
R
L
D
W
D
E
N
T
S
A
G
R
Y
V
R
E
N
C
K
P
L
R
R
Y
L
T
-
S
E
A
--
E
E
H
H
------------------------------------------
Q
L
F
-
D
L
I
E
S
M
L
E
Y
E
P
A
K
R
L
T
L
G
E
A
L
Q
H
P
F
F
A
R
L
R
A
-------------------------------------------------------------
75
HHSearch
60.99
32%
-108
- C1 -
4IIR
1
PRP4B_HUMAN
A:
[13-350]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
T
D
A
E
G
Y
Y
R
V
N
I
G
E
V
L
D
K
R
Y
N
V
Y
G
Y
T
G
Q
G
--
S
N
V
V
R
A
R
D
N
-
A
R
A
-
N
-
Q
E
V
A
V
K
I
I
R
N
N
----
E
L
M
Q
K
T
G
L
K
E
L
E
F
L
K
K
L
N
D
A
D
P
D
D
K
F
-------
H
C
L
R
L
F
R
H
F
Y
H
K
-----
Q
----
H
L
C
L
V
F
E
P
L
S
M
N
L
R
E
V
L
K
K
Y
G
K
D
V
G
L
H
I
K
A
V
R
S
Y
S
Q
Q
L
F
L
A
L
K
L
L
K
--
R
C
-
N
I
L
H
A
D
I
K
P
D
N
I
L
V
-----------------
N
----
E
S
K
------------------------
T
--------------
I
L
K
L
C
D
F
G
S
A
S
H
V
A
D
-
N
--
D
I
T
P
Y
L
V
S
R
F
Y
R
A
P
E
I
I
I
G
K
-
S
Y
D
Y
G
I
D
M
W
S
V
G
C
T
L
Y
E
L
Y
T
G
K
I
L
F
P
G
K
T
N
N
-------
H
M
L
K
L
A
M
D
L
K
G
K
M
P
N
K
M
I
R
K
G
--
V
F
--
K
D
Q
H
F
D
Q
N
L
N
-
F
M
Y
I
E
--------------
R
E
K
V
T
V
M
S
-
T
I
N
--
P
T
K
D
L
L
A
D
L
-----------------
I
----------L
P
E
D
Q
R
K
K
V
H
Q
L
K
D
L
L
D
Q
I
L
M
L
D
P
A
K
R
I
S
I
N
Q
A
L
Q
H
A
F
I
Q
E
----------------------------------------------------------------
73
HHSearch
60.86
39%
-98
* C1 *
1Z57
1
CLK1_HUMAN
A:
[7-334]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
S
G
D
V
L
S
A
R
Y
E
I
V
D
T
L
G
E
G
A
F
G
K
V
V
E
C
I
D
H
-
K
-
A
G
G
-
R
H
V
A
V
K
I
V
K
N
V
----
D
R
Y
C
E
A
A
R
S
E
I
Q
V
L
E
H
L
N
T
T
D
P
N
S
T
F
-------
R
C
V
Q
M
L
E
W
F
E
H
H
-----
G
----
H
I
C
I
V
F
E
L
L
G
L
S
T
Y
D
F
I
K
E
N
-
G
F
L
P
F
R
L
D
H
I
R
K
M
A
Y
Q
I
C
K
S
V
N
F
L
H
--
S
N
-
K
L
T
H
T
D
L
K
P
E
N
I
L
F
-----------------
V
----
Q
S
D
Y
T
E
A
Y
NR
D
E
R
T
L
I----------
N
P
--------------
D
I
K
V
V
D
F
G
S
A
T
Y
D
-
D
-
E
--
H
H
S
T
L
V
S
T
R
H
Y
R
A
P
E
V
I
L
A
L
-
G
W
S
Q
P
C
D
V
W
S
I
G
C
I
L
I
E
Y
Y
L
G
F
T
V
F
P
T
H
D
S
K
-------
E
H
L
A
M
M
E
R
I
L
G
P
L
P
K
H
M
I
Q
K
T
--
R
K
--
R
K
Y
F
H
H
D
R
L
D
W
D
E
H
-----
S
S
A
G
R
Y
V
-----
S
R
A
-----
C
K
P
---
L
K
E
F
M
L
-
S
-----------------
Q
D
V
-------
E
--------
H
E
R
L
F
D
L
I
Q
K
M
L
E
Y
D
P
A
K
R
I
T
L
R
E
A
L
K
H
P
F
F
D
L
L
K
K
-------------------------------------------------------------
48
PsiBlast_CBE
60.79
32%
-101
- C1 -
3NR9
1
CLK2_HUMAN
B:
[17-354]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
A
E
G
H
L
I
Y
H
V
G
D
W
L
Q
E
R
Y
E
I
V
S
T
L
G
E
G
T
F
G
R
V
V
Q
C
V
D
H
-
R
-
R
-
G
G
A
R
V
A
L
K
I
I
K
N
V
----
E
K
Y
K
E
A
A
R
L
E
I
N
V
L
E
K
I
N
E
K
D
P
D
N
K
N
-------
L
C
V
Q
M
F
D
W
F
D
Y
H
-----
G
----
H
M
C
I
S
F
E
L
L
G
L
S
T
F
D
F
L
K
D
N
-
N
Y
L
P
Y
P
I
H
Q
V
R
H
M
A
F
Q
L
C
Q
A
V
K
F
L
H
--
D
N
-
K
L
T
H
T
D
L
K
P
E
N
I
L
F
VNS
D
Y
E
L
T
Y
NLEK----
K
----
R
D
E
-----------------------
R
S
V
KST----------
A
V
R
V
V
D
F
G
S
A
T
F
D
-
H
-
E
--
H
H
S
T
I
V
S
T
R
H
Y
R
A
P
E
V
I
L
E
L
-
G
W
S
Q
P
C
D
V
W
S
I
G
C
I
I
F
E
Y
Y
V
G
F
T
L
F
Q
T
H
D
N
R
-------
E
H
L
A
M
M
E
R
I
L
G
P
I
P
S
R
M
I
R
K
T
--
R
K
--
Q
K
Y
F
Y
R
G
-----
R
L
D
W
D
E
N
T
S
A
G
R
Y
V
R
E
N
C
K
P
L
R
R
Y
L
T
-
S
E
A
--
E
E
H
H
------------------------------------------
Q
L
F
-
D
L
I
E
S
M
L
E
Y
E
P
A
K
R
L
T
L
G
E
A
L
Q
H
P
F
F
A
R
L
---------------------------------------------------------------
47
PsiBlast_CBE
60.72
32%
-103
- C1 -
3NR9
1
CLK2_HUMAN
C:
[17-355]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
A
E
G
H
L
I
Y
H
V
G
D
W
L
Q
E
R
Y
E
I
V
S
T
L
G
E
G
T
F
G
R
V
V
Q
C
V
D
H
-
R
-
R
-
G
G
A
R
V
A
L
K
I
I
K
N
V
----
E
K
Y
K
E
A
A
R
L
E
I
N
V
L
E
K
I
N
E
K
D
P
D
N
K
N
-------
L
C
V
Q
M
F
D
W
F
D
Y
H
-----
G
----
H
M
C
I
S
F
E
L
L
G
L
S
T
F
D
F
L
K
D
N
-
N
Y
L
P
Y
P
I
H
Q
V
R
H
M
A
F
Q
L
C
Q
A
V
K
F
L
H
--
D
N
-
K
L
T
H
T
D
L
K
P
E
N
I
L
F
VNSDYELTYNLEK----
K
----
R
D
E
-----------------------
R
S
VKST----------
A
V
R
V
V
D
F
G
S
A
T
F
D
-
H
-
E
--
H
H
S
T
I
V
S
T
R
H
Y
R
A
P
E
V
I
L
E
L
-
G
W
S
Q
P
C
D
V
W
S
I
G
C
I
I
F
E
Y
Y
V
G
F
T
L
F
Q
T
H
D
N
R
-------
E
H
L
A
M
M
E
R
I
L
G
P
I
P
S
R
M
I
R
K
T
--
R
K
--
Q
K
Y
F
Y
R
G
-----
R
L
D
W
D
E
N
T
S
A
G
R
Y
V
R
E
N
C
K
P
L
R
R
Y
L
T
-
S
E
A
--
E
E
H
H
------------------------------------------
Q
L
F
-
D
L
I
E
S
M
L
E
Y
E
P
A
K
R
L
T
L
G
E
A
L
Q
H
P
F
F
A
R
L
R
--------------------------------------------------------------
20
PsiBlast_PDB
60.14
32%
-101
- C1 -
2WU7
1
CLK3_HUMAN
A:
[32-369]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
V
E
------
D
D
K
E
G
H
L
V
C
R
I
G
D
W
L
Q
E
R
Y
E
I
V
G
N
L
G
E
G
T
F
G
K
V
V
E
C
L
D
H
A
R
-
G
-
K
-
S
Q
V
A
L
K
I
I
R
N
V
----
G
K
Y
R
E
A
A
R
L
E
I
N
V
L
K
K
I
K
E
K
D
K
E
N
K
F
-------
L
C
V
L
M
S
D
W
F
N
F
H
-----
G
----
H
M
C
I
A
F
E
L
L
G
K
N
T
F
E
F
L
K
E
N
-
N
F
Q
P
Y
P
L
P
H
V
R
H
M
A
Y
Q
L
C
H
A
L
R
F
L
H
--
E
N
-
Q
L
T
H
T
D
L
K
P
E
N
I
L
F
VNS
E
F
E
T
L
Y
NEHKS
C
E
E
K
----
S
V
K
-----------------------
N
T
--------------
S
I
R
V
A
D
F
G
S
A
T
F
D
-
H
-
E
--
H
H
T
T
I
V
A
T
R
H
Y
R
P
P
E
V
I
L
E
L
-
G
W
A
Q
P
C
D
V
W
S
I
G
C
I
L
F
E
Y
Y
R
G
F
T
L
F
Q
T
H
E
N
R
-------
E
H
L
V
M
M
E
K
I
L
G
P
I
P
S
H
M
I
H
R
T
--
R
K
--
Q
K
Y
F
Y
--
K
G
G
-
L
V
W
D
E
N
S
--
S
D
G
R
Y
V
K
E
N
C
K
---------
P
L
--
K
S
Y
M
L
Q
D
S
L
-----------------
E
H
V
-------
Q
-----------
L
F
D
L
M
R
R
M
L
E
F
D
P
A
Q
R
I
T
L
A
E
A
L
L
H
P
F
F
A
G
L
T
P
E
E
R
S
F
--------------------------------------------------------
19
PsiBlast_PDB
59.97
32%
-100
- C1 -
2WU6
7
CLK3_HUMAN
A:
[31-369]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
S
V
E
------
D
D
K
E
G
H
L
V
C
R
I
G
D
W
L
Q
E
R
Y
E
I
V
G
N
L
G
E
G
T
F
G
K
V
V
E
C
L
D
H
A
R
-
G
-
K
-
S
Q
V
A
L
K
I
I
R
N
V
----
G
K
Y
R
E
A
A
R
L
E
I
N
V
L
K
K
I
K
E
K
D
K
E
N
K
F
-------
L
C
V
L
M
S
D
W
F
N
F
H
-----
G
----
H
M
C
I
A
F
E
L
L
G
K
N
T
F
E
F
L
K
E
N
-
N
F
Q
P
Y
P
L
P
H
V
R
H
M
A
Y
Q
L
C
H
A
L
R
F
L
H
--
E
N
-
Q
L
T
H
T
D
L
K
P
E
N
I
L
F
VNS
E
F
E
T
L
Y
NEHKS
C
E
E
K
----
S
V
K
-----------------------
N
T
--------------
S
I
R
V
A
D
F
G
S
A
T
F
D
-
H
-
E
--
H
H
T
T
I
V
A
T
R
H
Y
R
P
P
E
V
I
L
E
L
-
G
W
A
Q
P
C
D
V
W
S
I
G
C
I
L
F
E
Y
Y
R
G
F
T
L
F
Q
T
H
E
N
R
-------
E
H
L
V
M
M
E
K
I
L
G
P
I
P
S
H
M
I
H
R
T
--
R
K
--
Q
K
Y
F
Y
--
K
G
G
-
L
V
W
D
E
N
S
--
S
D
G
R
Y
V
K
E
N
C
K
---------
P
L
--
K
S
Y
M
L
Q
D
S
L
-----------------
E
H
V
-------
Q
-----------
L
F
D
L
M
R
R
M
L
E
F
D
P
A
Q
R
I
T
L
A
E
A
L
L
H
P
F
F
A
G
L
T
P
E
E
R
S
F
H
-------------------------------------------------------
77
HHSearch
59.14
33%
-105
- C1 -
3LLT
1
?
A:
[20-360]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
E
I
V
H
F
S
W
K
K
G
M
L
L
N
N
A
F
L
V
I
R
K
M
G
D
G
T
F
G
R
V
L
L
C
Q
H
I
-
D
-
N
-
K
-
K
Y
Y
A
V
K
V
V
R
N
I
----
K
K
Y
T
R
S
A
K
I
E
A
D
I
L
K
K
I
Q
N
D
-
D
I
N
N
N
-------
N
I
V
K
Y
H
G
K
F
M
Y
Y
-----
D
----
H
M
C
L
I
F
E
P
L
G
P
S
L
Y
E
I
I
T
R
N
-
N
Y
N
G
F
H
I
E
D
I
K
L
Y
C
I
E
I
L
K
A
L
N
Y
L
R
--
K
M
-
S
L
T
H
T
D
L
K
P
E
N
I
L
L
-----------------
D
----
D
P
Y
F
E
K
S
L
I
T
V
R
R
VTDG
K
K
I
Q
I
Y
R
T
K
S
T
--------------
G
I
K
L
I
D
F
G
C
A
T
F
K
-
S
-
D
--
Y
H
G
S
I
I
N
T
R
Q
Y
R
A
P
E
V
I
L
N
L
-
G
W
D
V
S
S
D
M
W
S
F
G
C
V
L
A
E
L
Y
T
G
S
L
L
F
R
T
H
E
H
M
-------
E
H
L
A
M
M
E
S
I
I
Q
P
I
P
K
N
M
L
Y
E
A
--
T
K
T
N
G
S
K
Y
V
N
K
D
E
L
-------------------------
K
L
A
-
W
P
E
NA
S
S
I
N
S
I
K
H
V
-----------------
K
K
C
LP
L
Y
K
I
I
K
--------
H
E
L
F
C
D
F
L
Y
S
I
L
Q
I
D
P
T
L
R
P
S
P
A
E
L
L
K
H
K
F
L
E
-----------------------------------------------------------------
85
HHSearch
59.12
31%
-116
- C1 -
4BGQ
3
CDKL5_HUMAN
A:
[12-300]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
K
F
E
I
L
G
V
V
G
E
G
A
Y
G
V
V
L
K
C
R
H
K
-
E
-
T
-
H
-
E
I
V
A
I
K
K
F
K
--------
V
K
E
T
T
L
R
E
L
K
M
L
R
T
L
K
------
Q
E
-------
N
I
V
E
L
K
E
A
F
R
R
R
-----
G
----
K
L
Y
L
V
F
E
Y
V
E
K
N
M
L
E
L
L
E
E
M
-
P
-
N
G
V
P
P
E
K
V
K
S
Y
I
Y
Q
L
I
K
A
I
H
W
C
H
--
K
N
-
D
I
V
H
R
D
I
K
P
E
N
L
L
I
-----------------
S
----
H
N
D
---------------------------------------
V
L
K
L
C
D
F
G
F
A
R
N
L
-
S
E----------
T
R
W
Y
R
S
P
E
L
L
L
G
A
-
P
Y
G
K
S
V
D
M
W
S
V
G
C
I
L
G
E
L
S
D
G
Q
P
L
F
P
G
E
S
E
I
-------
D
Q
L
F
T
I
Q
K
V
L
G
P
L
P
S
E
Q
M
K
L
F
--
Y
S
--
N
P
R
F
H
-
G
L
R
F
-
P
---------------------------
A
V
N
--
H
P
Q
S
L
E
R
R
Y
-----------------
L
G
I
-------
L
--------
N
S
V
L
L
D
L
M
K
N
L
L
K
L
D
P
A
D
R
Y
L
T
E
Q
C
L
N
H
P
T
F
Q
T
Q
R
L
-------------------------------------------------------------
16
PsiBlast_PDB
58.75
35%
-98
- C1 -
1Z57
1
CLK1_HUMAN
A:
[10-332]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
V
L
S
A
R
Y
E
I
V
D
T
L
G
E
G
A
F
G
K
V
V
E
C
I
D
H
-
K
-
A
-
G
G
R
H
V
A
V
K
I
V
K
N
V
----
D
R
Y
C
E
A
A
R
S
E
I
Q
V
L
E
H
L
N
T
T
D
P
N
S
T
F
-------
R
C
V
Q
M
L
E
W
F
E
H
H
-----
G
----
H
I
C
I
V
F
E
L
L
G
L
S
T
Y
D
F
I
K
E
N
-
G
F
L
P
F
R
L
D
H
I
R
K
M
A
Y
Q
I
C
K
S
V
N
F
L
H
--
S
N
-
K
L
T
H
T
D
L
K
P
E
N
I
L
F
-----------------
V
----
Q
S
D
-----------------------
Y
T
E
A
Y
NR
D
E
R
T
L
INP-
D
I
K
V
V
D
F
G
S
A
T
Y
D
-
D
-
E
--
H
H
S
T
L
V
S
T
R
H
Y
R
A
P
E
V
I
L
A
L
-
G
W
S
Q
P
C
D
V
W
S
I
G
C
I
L
I
E
Y
Y
L
G
F
T
V
F
P
T
H
D
S
K
-------
E
H
L
A
M
M
E
R
I
L
G
P
L
P
K
H
M
I
Q
K
T
--
R
K
--
R
K
Y
F
H
H
D
R
------------
L
D
W
D
E
H
S
S
A
G
R
Y
V
S
---
R
-
A
C
K
--
P
L
K
E
F
M
L
S
Q
-----------------
D
V
E
-------
H
--------
E
R
L
F
-
D
L
I
Q
K
M
L
E
Y
D
P
A
K
R
I
T
L
R
E
A
L
K
H
P
F
F
D
L
L
K
K
-------------------------------------------------------------
17
PsiBlast_PDB
58.69
35%
-97
- C1 -
2VAG
1
CLK1_HUMAN
A:
[10-332]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
V
L
S
A
R
Y
E
I
V
D
T
L
G
E
G
A
F
G
K
V
V
E
C
I
D
H
-
K
-
A
-
G
G
R
H
V
A
V
K
I
V
K
N
V
----
D
R
Y
C
E
A
A
R
S
E
I
Q
V
L
E
H
L
N
T
T
D
P
N
S
T
F
-------
R
C
V
Q
M
L
E
W
F
E
H
H
-----
G
----
H
I
C
I
V
F
E
L
L
G
L
S
T
Y
D
F
I
K
E
N
-
G
F
L
P
F
R
L
D
H
I
R
K
M
A
Y
Q
I
C
K
S
V
N
F
L
H
--
S
N
-
K
L
T
H
T
D
L
K
P
E
N
I
L
F
-----------------
V
----
Q
S
D
-----------------------
Y
T
E
A
Y
NK
R
D
E
R
T
L
INP
D
I
K
V
V
D
F
G
S
A
T
Y
D
-
D
-
E
--
H
H
S
T
L
V
S
T
R
H
Y
R
A
P
E
V
I
L
A
L
-
G
W
S
Q
P
C
D
V
W
S
I
G
C
I
L
I
E
Y
Y
L
G
F
T
V
F
P
T
H
D
S
K
-------
E
H
L
A
M
M
E
R
I
L
G
P
L
P
K
H
M
I
Q
K
T
--
R
K
--
R
K
Y
F
H
H
D
R
------------
L
D
W
D
E
H
S
S
A
G
R
Y
V
S
---
R
-
A
C
K
--
P
L
K
E
F
M
L
S
Q
-----------------
D
V
E
-------
H
--------
E
R
L
F
-
D
L
I
Q
K
M
L
E
Y
D
P
A
K
R
I
T
L
R
E
A
L
K
H
P
F
F
D
L
L
K
--------------------------------------------------------------
50
PsiBlast_CBE
58.17
32%
-97
- C1 -
3RAW
1
CLK3_HUMAN
A:
[31-369]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
S
V
E
------
D
D
K
E
G
H
L
V
C
R
I
G
D
W
L
Q
E
R
Y
E
I
V
G
N
L
G
E
G
T
F
G
K
V
V
E
C
L
D
H
A
R
-
G
-
K
-
S
Q
V
A
L
K
I
I
R
N
V
----
G
K
Y
R
E
A
A
R
L
E
I
N
V
L
K
K
I
K
E
K
D
K
E
N
K
F
-------
L
C
V
L
M
S
D
W
F
N
F
H
-----
G
----
H
M
C
I
A
F
E
L
L
G
K
N
T
F
E
F
L
K
E
N
-
N
F
Q
P
Y
P
L
P
H
V
R
H
M
A
Y
Q
L
C
H
A
L
R
F
L
H
--
E
N
-
Q
L
T
H
T
D
L
K
P
E
N
I
L
F
VNS
E
F
E
T
L
Y
N
EHKS
C
E
E
K
----
S
V
K
-----------------------
N
T
--------------
S
I
R
V
A
D
F
G
S
A
T
F
D
-
H
-
E
--
H
H
T
T
I
V
A
T
R
H
Y
R
P
P
E
V
I
L
E
L
-
G
W
A
Q
P
C
D
V
W
S
I
G
C
I
L
F
E
Y
Y
R
G
F
T
L
F
Q
T
H
E
N
R
-------
E
H
L
V
M
M
E
K
I
L
G
P
I
P
S
H
M
I
H
R
T
--
R
K
--
Q
K
Y
F
Y
--
K
G
G
-
L
V
W
D
E
N
S
--
S
D
G
R
Y
V
K
E
N
C
K
---------
P
L
--
K
S
Y
M
L
Q
D
S
L
-----------------
E
H
V
-------
Q
-----------
L
F
D
L
M
R
R
M
L
E
F
D
P
A
Q
R
I
T
L
A
E
A
L
L
H
P
F
F
A
G
L
T
P
E
E
R
S
F
H
T
------------------------------------------------------
49
PsiBlast_CBE
58.12
32%
-97
- C1 -
3RAW
1
CLK3_HUMAN
B:
[33-369]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
E
------
D
D
K
E
G
H
L
V
C
R
I
G
D
W
L
Q
E
R
Y
E
I
V
G
N
L
G
E
G
T
F
G
K
V
V
E
C
L
D
H
A
R
-
G
-
K
-
S
Q
V
A
L
K
I
I
R
N
V
----
G
K
Y
R
E
A
A
R
L
E
I
N
V
L
K
K
I
K
E
K
D
K
E
N
K
F
-------
L
C
V
L
M
S
D
W
F
N
F
H
-----
G
----
H
M
C
I
A
F
E
L
L
G
K
N
T
F
E
F
L
K
E
N
-
N
F
Q
P
Y
P
L
P
H
V
R
H
M
A
Y
Q
L
C
H
A
L
R
F
L
H
--
E
N
-
Q
L
T
H
T
D
L
K
P
E
N
I
L
F
VNS
E
F
E
T
L
Y
N
EHKS
C
E
E
K
----
S
V
K
-----------------------
N
T
--------------
S
I
R
V
A
D
F
G
S
A
T
F
D
-
H
-
E
--
H
H
T
T
I
V
A
T
R
H
Y
R
P
P
E
V
I
L
E
L
-
G
W
A
Q
P
C
D
V
W
S
I
G
C
I
L
F
E
Y
Y
R
G
F
T
L
F
Q
T
H
E
N
R
-------
E
H
L
V
M
M
E
K
I
L
G
P
I
P
S
H
M
I
H
R
T
--
R
K
--
Q
K
Y
F
Y
--
K
G
G
-
L
V
W
D
E
N
S
--
S
D
G
R
Y
V
K
E
N
C
K
---------
P
L
--
K
S
Y
M
L
Q
D
S
L
-----------------
E
H
V
-------
Q
-----------
L
F
D
L
M
R
R
M
L
E
F
D
P
A
Q
R
I
T
L
A
E
A
L
L
H
P
F
F
A
G
L
T
P
E
E
R
S
F
H
T
------------------------------------------------------
53
PsiBlast_CBE
57.90
33%
-104
- C1 -
1Q99
2
SKY1_YEAST
A:
[20-341]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
Y
I
L
V
R
K
L
G
W
G
H
F
S
T
V
W
L
A
K
D
M
-
V
-
N
-
N
-
T
H
V
A
M
K
I
V
R
G
D
----
K
V
Y
T
E
A
A
E
D
E
I
K
L
L
Q
--
R
V
N
D
A
D
N
T
K
E
D
S
M
G
A
N
H
I
L
K
L
L
D
H
F
N
H
K
-----
G
PN
G
V
H
V
V
M
V
F
E
V
L
G
E
N
L
L
A
L
I
K
K
Y
-
E
H
R
G
I
P
L
I
Y
V
K
Q
I
S
K
Q
L
L
L
G
L
D
Y
M
H
--
R
R
C
G
I
I
H
T
D
I
K
P
E
N
V
L
M
-----------------
E
I
VDS
P
E
N
-----------------------
L
I
--------------
Q
I
K
I
A
D
L
G
N
A
C
W
Y
-
D
-
E
--
H
Y
T
N
S
I
Q
T
R
E
Y
R
S
P
E
V
L
L
G
A
-
P
W
G
C
G
A
D
I
W
S
T
A
C
L
I
F
E
L
I
T
G
-
D
F
L
F
E
----T
K
D
D
---
D
H
I
A
Q
I
I
E
L
L
G
E
L
P
S
Y
L
L
R
N
G
--
K
Y
--
T
R
T
F
F
N
S
--
L
-
L
R
N
I
S
K
L
K
F
W
P
L
E
D
V
L
----
T
E
K
Y
K
F
--
S
K
D
--
E
A
K
E
--------------------------------------------
I
S
D
F
L
S
P
M
L
Q
L
D
P
R
K
R
A
D
A
G
G
L
V
N
H
P
W
L
K
D
T
L
G
M
E
E
I
R
V
P
D
R
E
L
Y
G
S
G
S
D
I
P
G
W
F
E
E
V
R
-----------------------------------
52
PsiBlast_CBE
57.49
33%
-100
- C1 -
1Q99
2
SKY1_YEAST
B:
[20-341]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
Y
I
L
V
R
K
L
G
W
G
H
F
S
T
V
W
L
A
K
D
M
-
V
-
N
-
N
-
T
H
V
A
M
K
I
V
R
G
D
----
K
V
Y
T
E
A
A
E
D
E
I
K
L
L
Q
--
R
V
N
D
A
D
N
T
K
E
D
S
M
G
A
N
H
I
L
K
L
L
D
H
F
N
H
K
-----
G
PN
G
V
H
V
V
M
V
F
E
V
L
G
E
N
L
L
A
L
I
K
K
Y
-
E
H
R
G
I
P
L
I
Y
V
K
Q
I
S
K
Q
L
L
L
G
L
D
Y
M
H
--
R
R
C
G
I
I
H
T
D
I
K
P
E
N
V
L
M
-----------------
E
I
VDS
P
E
N
-----------------------
L
I
--------------
Q
I
K
I
A
D
L
G
N
A
C
W
Y
-
D
-
E
--
H
Y
T
N
S
I
Q
T
R
E
Y
R
S
P
E
V
L
L
G
A
-
P
W
G
C
G
A
D
I
W
S
T
A
C
L
I
F
E
L
I
T
G
-
D
F
L
F
E
P
D
E
G
HSYT
K
D
D
D
H
I
A
Q
I
I
E
L
L
G
E
L
P
S
Y
L
L
R
N
G
--
K
Y
--
T
R
T
F
F
N
S
R
G
L
-
L
R
N
I
S
K
L
K
F
W
P
L
E
D
V
L
----
T
E
K
Y
K
F
--
S
K
D
--
E
A
K
E
--------------------------------------------
I
S
D
F
L
S
P
M
L
Q
L
D
P
R
K
R
A
D
A
G
G
L
V
N
H
P
W
L
K
D
T
L
G
M
E
E
I
R
V
P
D
R
E
L
Y
G
S
G
S
D
I
P
G
W
F
E
E
V
R
-----------------------------------
93
HHSearch
57.36
31%
-122
- C1 -
4QNY
1
?
A:
[19-315]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
R
Y
L
L
E
R
I
I
G
A
G
S
Y
G
V
V
I
R
A
R
D
T
-
K
-
S
D
N
-
R
L
V
A
M
K
R
V
N
K
E
I
F
E
E
V
I
L
A
K
R
I
L
R
E
I
K
L
L
A
H
F
N
------
D
D
-------
N
I
I
G
L
R
N
I
L
T
P
E
DPENF
D
----
H
F
Y
I
V
M
D
I
M
E
T
D
L
K
Q
V
L
R
S
G
---
Q
E
L
T
E
A
H
I
Q
F
F
I
Y
Q
A
L
R
A
L
H
I
I
H
--
S
A
-
G
V
I
H
R
D
I
T
P
A
N
I
L
V
-----------------
N
----
T
N
C
-----------------------
D
----------------
L
K
I
C
D
F
G
L
A
K
E
E
----G
E
Y
M
T
D
Y
V
T
M
R
W
Y
R
A
P
E
L
V
M
E
D
K
D
Y
S
A
Q
I
D
V
W
G
I
G
C
I
L
G
E
L
L
G
S
R
P
L
F
Q
G
K
D
R
V
-------
N
Q
L
D
K
I
V
D
V
I
G
T
P
S
E
E
D
I
N
S
V
GS
S
A
--
A
Q
K
Y
L
K
K
K
S
H
-------------------------------
R
--
P
Q
A
D
W
R
Q
R
Y
-----------------
P
T
A
----------------
S
P
E
A
L
D
L
L
R
H
M
L
V
F
N
P
K
R
R
I
T
V
L
Q
A
M
R
H
P
F
L
E
Q
L
H
D
D
Y
A
L
F
R
F
D
T
I
V
D
V
K
R
A
I
Y
E
E
S
V
K
F
-------------------------------------
12
PsiBlast_PDB
50.98
43%
-72
- C1 -
4YLK
13
DYR1A_HUMAN
A:
[34-357]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
Y
E
I
D
S
L
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
R
-
V
-
E
-
Q
-
E
W
V
A
I
K
I
I
K
N
K
----
K
A
F
L
N
Q
A
Q
I
E
V
R
L
L
E
L
M
N
K
H
D
T
E
M
K
Y
-------
Y
I
V
H
L
K
R
H
F
M
F
R
-----
N
----
H
L
C
L
V
F
E
M
L
S
Y
N
L
Y
D
L
L
R
N
T
-
N
F
R
G
V
S
L
N
L
T
R
K
F
A
Q
Q
M
C
T
A
L
L
F
L
A
TP
E
L
-
S
I
I
H
C
D
L
K
P
E
N
I
L
L
-----------------
C
----
N
P
K
-----------------------
R
S
--------------
A
I
K
I
V
D
F
G
S
S
C
Q
L
-
G
-
Q
--
R
I
Y
Q
Y
I
Q
S
R
F
Y
R
S
P
E
V
L
L
G
M
-
P
Y
D
L
A
I
D
M
W
S
L
G
C
I
L
V
E
M
H
T
G
E
P
L
F
S
G
A
N
E
V
-------
D
Q
M
N
K
I
V
E
V
L
G
I
P
P
A
H
I
L
D
Q
A
--
P
K
--
A
R
K
F
F
E
K
------------
L
P
D
G
T
--
W
N
L
K
K
------
E
Y
K
P
P
--
G
T
R
K
L
H
N
I
L
GVETGGPGGRRAGESGH
T
V
A
-------
D
--------
Y
L
K
F
K
D
L
I
L
R
M
L
D
Y
D
P
K
T
R
I
Q
P
Y
Y
A
L
Q
H
S
F
F
K
K
----------------------------------------------------------------