@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : DYRK4_HUMAN: (2015-10-06 )
MPASELKASEIPFHPSIKTQDPKAEEKSPKKQKVTLTAAEALKLFKNQLSPYEQSEILGYAELWFLGLEAKKLDTAPEKFSKTSFDDEHGFYLKVLHDHIAYRYEVLETIGKGSFGQVAKCLDHKNNELVALKIIRNKKRFHQQALMELKILEALRKKDKDNTYNVVHMKDFFYFRNHFCITFELLGINLYELMKNNNFQGFSLSIVRRFTLSVLKCLQMLSVEKIIHCDLKPENIVLYQKGQASVKVIDFGSSCYEHQKVYTYIQSRFYRSPEVILGHPYDVAIDMWSLGCITAELYTGYPLFPGENEVEQLACIMEVLGLPPAGFIQTASRRQTFFDSKGFPKNITNNRGKKRYPDSKDLTMVLKTYDTSFLDFLRRCLVWEPSLRMTPDQALKHAWIHQSRNLKPQPRPQTLRKSNSFFPSETRKDKVQGCHHSSRKADEITKETTEKTKDSPTKHVQHSGDQQDCLQHGADTVQLPQLVDAPKKSEAAVGAEVSMTSPGQSKNFSLKNTNVLPPIV
Atome Classification :
(26 SA)
.........10........20........30....-....40........50........60........70........80........90........100.......110.......120..-.-....130.......140.......150.......160.-------......170.....----..180.......190......-.200.......210.......220..-.--....230.....--------.-----------------------.240----------------------.-----------------..--------------.....250.....-..260.......270.......280.......290.......300..-....-----.310.......320.......330.--..-....340----.......-------------.350---..----...--.-..360....------.-------..-370------------------.......380.......390.......400.......410-.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
P
A
S
ELKASEIPFHPSIKTQDPKAEEKSPKK
Q
K
V
T
-
L
T
A
A
E
A
L
K
L
F
K
N
QLSPY
E
Q
S
E
I
L
G
Y
A
E
L
W
FLGLEAKKLDTA
P
E
K
FSKTSFDDEHG
F
Y
L
K
V
L
H
D
H
I
A
Y
R
Y
E
V
L
E
T
IGKG
S
F
G
Q
V
A
K
C
L
DH-K-NN
E
L
V
A
L
K
I
I
R
N
K
K
R
F
H
Q
Q
A
L
M
E
L
K
I
L
E
A
L
R
KKDKDNT-------
Y
N
V
V
H
M
K
D
F
F
Y
F
RN----
H
F
C
I
T
F
E
LLG
I
N
L
Y
E
L
M
KNNN-FQG
F
S
L
S
I
V
R
R
F
T
L
S
V
L
K
C
L
Q
M
L
S
V
E
-
K
--
I
IHCDLKPE
N
I
V
--------
L
-----------------------
Y
QK-----------------------G-----------------Q
A
--------------
S
V
K
V
I
DFGS
S
C
Y
E
-
H
Q
K
V
Y
T
Y
I
Q
S
R
FYRSP
E
V
I
LGHPY
D
V
A
I
D
M
WSL
G
C
I
T
A
E
L
YTGYPLF-PGE
N
-----
E
V
E
Q
L
A
C
I
M
E
V
LGLPP
A
G
F
I
Q
T
A
S
R
--
R
Q
-TFFDSK-----GFPKNIT-------------NNR----GK----KRY--P-DSK
D
L
T
M
V
L
------K-------TY-D
T
S
------------------
F
L
D
F
L
R
R
CLVWEPSLRM
T
P
D
Q
A
L
K
H
A
W
I
HQSRNLKPQPR
P
-
Q
T
L
RKSNSFFPSETR
K
D
K
V
QGCHHSSR
K
A
D
E
I
T
K
E
T
T
EKTKDSPT
K
H
VQHSG
D
Q
Q
D
C
L
Q
HGADTVQL
P
Q
L
VDAPKKSEAAVG
A
E
V
S
MTSPGQSKNFSLKNTNVLPPIV
73
HHSearch
89.64
57%
-111
* C1 *
3KVW
1
DYRK2_HUMAN
A:
[26-413]
------------------------------
V
K
A
T
P
-
M
T
P
E
Q
A
M
K
Q
Y
M
Q
K
L
T
A
F
E
H
H
E
I
F
S
Y
P
E
I
Y
F
L
G
L
N
A
K
K
R
Q
G
M
T
G
G
P
N
N
G
G
Y
D
D
D
Q
G
S
Y
V
Q
V
P
H
D
H
V
A
Y
R
Y
E
V
L
K
V
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
H
-
K
-
V
H
Q
H
V
A
L
K
M
V
R
N
E
K
R
F
H
R
Q
A
A
E
E
I
R
I
L
E
H
L
R
K
Q
D
K
D
N
T
-------
M
N
V
I
H
M
L
E
N
F
T
F
R
N
----
H
I
C
M
T
F
E
L
L
S
M
N
L
Y
E
L
I
K
K
N
K
-
F
Q
G
F
S
L
P
L
V
R
K
F
A
H
S
I
L
Q
C
L
D
A
L
H
K
N
-
R
--
I
I
H
C
D
L
K
P
E
N
I
L
--------
L
-----------------------
K
Q
Q
-----------------------
G
-----------------
R
S
--------------
G
I
K
V
I
D
F
G
S
S
C
Y
E
-
H
Q
R
V
Y
T
Y
I
Q
S
R
F
Y
R
A
P
E
V
I
L
G
A
R
Y
G
M
P
I
D
M
W
S
L
G
C
I
L
A
E
L
L
T
G
Y
P
L
L
-
P
G
E
D
-----
E
G
D
Q
L
A
C
M
I
E
L
L
G
M
P
S
Q
K
L
L
D
A
S
K
R
--
A
K
-
N
F
V
S
S
K
-----
G
Y
P
R
Y
C
T
V
T
TLS
D
V
V
L
N
G
G
R
S
R
R
----
G
K
----
L
R
G
--
P
P
E
S
R
E
W
G
N
A
L
------
K
-------
G
C
D
D
P
L
------------------
F
L
D
F
L
K
Q
C
L
E
W
D
P
A
V
R
M
T
P
G
Q
A
L
R
H
P
W
L
R
------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
89.29
54%
-113
- C1 -
4AZF
2
DYRK2_HUMAN
A:
[21-413]
--------------------------
Q
S
M
G
K
V
K
A
T
P
M
T
P
E
Q
A
M
K
Q
Y
M
Q
K
L
T
A
F
E
H
H
E
I
F
S
Y
P
E
I
Y
F
L
G
L
N
A
K
K
R
Q
G
M
T
G
G
P
N
N
G
G
Y
D
D
D
Q
G
S
Y
V
Q
V
P
H
D
H
V
A
Y
R
Y
E
V
L
K
V
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
H
-
K
-
V
H
Q
H
V
A
L
K
M
V
R
N
E
K
R
F
H
R
Q
A
A
E
E
I
R
I
L
E
H
L
R
K
Q
D
K
D
N
T
-------
M
N
V
I
H
M
L
E
N
F
T
F
R
N
----
H
I
C
M
T
F
E
L
L
S
M
N
L
Y
E
L
I
K
K
N
K
-
F
Q
G
F
S
L
P
L
V
R
K
F
A
H
S
I
L
Q
C
L
D
A
L
H
K
N
-
R
--
I
I
H
C
D
L
K
P
E
N
I
L
--------
L
-----------------------
K
Q
Q
-----------------------
G
-----------------
R
S
--------------
G
I
K
V
I
D
F
G
S
S
C
Y
E
-
H
Q
R
V
Y
T
Y
I
Q
S
R
F
Y
R
A
P
E
V
I
L
G
A
R
Y
G
M
P
I
D
M
W
S
L
G
C
I
L
A
E
L
L
T
G
Y
P
L
L
-
P
G
E
D
-----
E
G
D
Q
L
A
C
M
I
E
L
L
G
M
P
S
Q
K
L
L
D
A
S
K
R
--
A
K
-
N
F
V
S
S
K
-----
G
Y
P
R
Y
C
T
V
T
TLS
D
V
V
L
N
G
G
R
S
R
R
----
G
K
----
L
R
G
P-
P
-
E
S
R
E
W
G
N
A
L
------
K
-------
G
C
-
D
D
P
L
-----------------
F
L
D
F
L
K
Q
C
L
E
W
D
P
A
V
R
M
T
P
G
Q
A
L
R
H
P
W
L
R
------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
88.18
53%
-112
- C1 -
3KVW
1
DYRK2_HUMAN
A:
[25-413]
-----------------------------
K
V
K
A
T
P
-
M
T
P
E
Q
A
M
K
Q
Y
M
Q
K
L
T
A
F
E
H
H
E
I
F
S
Y
P
E
I
Y
F
L
G
L
N
A
K
K
R
Q
G
M
T
G
G
P
N
N
G
G
Y
D
D
D
Q
G
S
Y
V
Q
V
P
H
D
H
V
A
Y
R
Y
E
V
L
K
V
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
H
-
K
-
V
H
Q
H
V
A
L
K
M
V
R
N
E
K
R
F
H
R
Q
A
A
E
E
I
R
I
L
E
H
L
R
K
Q
D
K
D
N
T
-------
M
N
V
I
H
M
L
E
N
F
T
F
R
N
----
H
I
C
M
T
F
E
L
L
S
M
N
L
Y
E
L
I
K
K
N
K
-
F
Q
G
F
S
L
P
L
V
R
K
F
A
H
S
I
L
Q
C
L
D
A
L
H
K
N
-
R
--
I
I
H
C
D
L
K
P
E
N
I
L
--------
L
-----------------------
K
Q
Q
-----------------------
G
-----------------
R
S
--------------
G
I
K
V
I
D
F
G
S
S
C
Y
E
-
H
Q
R
V
Y
T
Y
I
Q
S
R
F
Y
R
A
P
E
V
I
L
G
A
R
Y
G
M
P
I
D
M
W
S
L
G
C
I
L
A
E
L
L
T
G
Y
P
L
L
-
P
G
E
D
-----
E
G
D
Q
L
A
C
M
I
E
L
L
G
M
P
S
Q
K
L
L
D
A
S
K
R
--
A
K
-
N
F
V
S
S
K
-----
G
Y
P
R
Y
C
T
V
T
TLS
D
V
V
L
N
G
G
R
S
R
R
----
G
K
----
L
R
G
P-
P
-
E
S
R
E
W
G
N
A
L
------
K
-------
G
C
-
D
D
P
L
-----------------
F
L
D
F
L
K
Q
C
L
E
W
D
P
A
V
R
M
T
P
G
Q
A
L
R
H
P
W
L
R
------------------------------------------------------------------------------------------------------------------------
32
PsiBlast_CBE
80.56
44%
-127
- C1 -
2WO6
1
DYR1A_HUMAN
B:
[55-377]
-------------------------------------------------------------------------------------------------------
R
Y
E
I
D
S
L
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
R
-
V
-
E
Q
E
W
V
A
I
K
I
I
K
N
K
K
A
F
L
N
Q
A
Q
I
E
V
R
L
L
E
L
M
N
K
H
D
T
E
M
K
-------
Y
Y
I
V
H
L
K
R
H
F
M
F
R
N
----
H
L
C
L
V
F
E
M
L
S
Y
N
L
Y
D
L
L
R
N
T
N
-
F
R
G
V
S
L
N
L
T
R
K
F
A
Q
Q
M
C
T
A
L
L
F
L
A
T
P
-
E
LS
I
I
H
C
D
L
K
P
E
N
I
L
--------
L
-----------------------
C
N
P
-----------------------
K
-----------------
R
S
--------------
A
I
K
I
V
D
F
G
S
S
C
Q
L
-
G
Q
R
I
Y
Q
Y
I
Q
S
R
F
Y
R
S
P
E
V
L
L
G
M
P
Y
D
L
A
I
D
M
W
S
L
G
C
I
L
V
E
M
H
T
G
E
P
L
F
-
S
G
A
N
-----
E
V
D
Q
M
N
K
I
V
E
V
L
G
I
P
P
A
H
I
L
D
Q
A
P
K
--
A
R
-
K
F
F
E
K
-------
L
P
D
G
T
W
-------------
N
L
K
K---------
R
E
Y
KP
P
-
G
T
R
K
L
H
N
I
L
------
G
-------
V
E
-
T
G
G
PGGRRAGESGH
T
V
A
D
Y
L
K
F
K
D
L
I
L
R
M
L
D
Y
D
P
K
T
R
I
Q
P
Y
Y
A
L
Q
H
S
F
F
K
------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
77.44
44%
-128
- C1 -
4AZE
1
DYR1A_HUMAN
A:
[55-378]
-------------------------------------------------------------------------------------------------------
R
Y
E
I
D
S
L
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
R
-
V
-
E
Q
E
W
V
A
I
K
I
I
K
N
K
K
A
F
L
N
Q
A
Q
I
E
V
R
L
L
E
L
M
N
K
H
D
T
E
M
K
-------
Y
Y
I
V
H
L
K
R
H
F
M
F
R
N
----
H
L
C
L
V
F
E
M
L
S
Y
N
L
Y
D
L
L
R
N
T
N
-
F
R
G
V
S
L
N
L
T
R
K
F
A
Q
Q
M
C
T
A
L
L
F
L
A
T
P
-
E
LS
I
I
H
C
D
L
K
P
E
N
I
L
--------
L
-----------------------
C
N
P
-----------------------
K
-----------------
R
S
--------------
A
I
K
I
V
D
F
G
S
S
C
Q
L
-
G
Q
R
I
Y
Q
Y
I
Q
S
R
F
Y
R
S
P
E
V
L
L
G
M
P
Y
D
L
A
I
D
M
W
S
L
G
C
I
L
V
E
M
H
T
G
E
P
L
F
-
S
G
A
N
-----
E
V
D
Q
M
N
K
I
V
E
V
L
G
I
P
P
A
H
I
L
D
Q
A
P
K
--
A
R
-
K
F
F
E
K
-------
L
P
D
G
T
W
-------------
N
L
K
KTKD
G
K
----
R
E
Y
KP
P
-
G
T
R
K
L
H
N
I
L
------
G
-------
V
E
-
T
G
G
PGGRRAGESG
H
T
V
A
D
Y
L
K
F
K
D
L
I
L
R
M
L
D
Y
D
P
K
T
R
I
Q
P
Y
Y
A
L
Q
H
S
F
F
K
K
-----------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
77.40
44%
-124
- C1 -
2WO6
1
DYR1A_HUMAN
A:
[55-378]
-------------------------------------------------------------------------------------------------------
R
Y
E
I
D
S
L
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
R
-
V
-
E
Q
E
W
V
A
I
K
I
I
K
N
K
K
A
F
L
N
Q
A
Q
I
E
V
R
L
L
E
L
M
N
K
H
D
T
E
M
K
-------
Y
Y
I
V
H
L
K
R
H
F
M
F
R
N
----
H
L
C
L
V
F
E
M
L
S
Y
N
L
Y
D
L
L
R
N
T
N
-
F
R
G
V
S
L
N
L
T
R
K
F
A
Q
Q
M
C
T
A
L
L
F
L
A
T
P
-
E
LS
I
I
H
C
D
L
K
P
E
N
I
L
--------
L
-----------------------
C
N
P
-----------------------
K
-----------------
R
S
--------------
A
I
K
I
V
D
F
G
S
S
C
Q
L
-
G
Q
R
I
Y
Q
Y
I
Q
S
R
F
Y
R
S
P
E
V
L
L
G
M
P
Y
D
L
A
I
D
M
W
S
L
G
C
I
L
V
E
M
H
T
G
E
P
L
F
-
S
G
A
N
-----
E
V
D
Q
M
N
K
I
V
E
V
L
G
I
P
P
A
H
I
L
D
Q
A
P
K
--
A
R
-
K
F
F
E
K
-------
L
P
D
G
T
W
-------------
N
L
K
KT--------
R
E
Y
KP
P
-
G
T
R
K
L
H
N
I
L
------
G
-------
V
E
-
T
G
G
PGGRRAGESGH
T
V
A
D
Y
L
K
F
K
D
L
I
L
R
M
L
D
Y
D
P
K
T
R
I
Q
P
Y
Y
A
L
Q
H
S
F
F
K
K
-----------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
69.38
33%
-105
- C1 -
2WU6
7
CLK3_HUMAN
A:
[31-377]
----------------------------------------------------------------------------------
R
S
V
E
D
D
K
E
G
H
L
V
C
R
I
G
D
W
L
Q
E
R
Y
E
I
V
G
N
L
G
E
G
T
F
G
K
V
V
E
C
L
D
H
A
R
-
G
K
S
Q
V
A
L
K
I
I
R
N
V
G
K
Y
R
E
A
A
R
L
E
I
N
V
L
K
K
I
K
E
K
D
K
E
N
K
-------
F
L
C
V
L
M
S
D
W
F
N
F
H
G
----
H
M
C
I
A
F
E
L
L
G
K
N
T
F
E
F
L
K
E
N
N
-
F
Q
P
Y
P
L
P
H
V
R
H
M
A
Y
Q
L
C
H
A
L
R
F
L
H
E
N
-
Q
--
L
T
H
T
D
L
K
P
E
N
I
L
F
VNS
E
F
E
T
L
-----------------------
Y
N
E
-----------------------
H
-----------------
K
S
C
E
E
K
S
V
KNT-----
S
I
R
V
A
D
F
G
S
A
T
F
D
-
H
E
H
H
T
T
I
V
A
T
R
H
Y
R
P
P
E
V
I
L
E
L
G
W
A
Q
P
C
D
V
W
S
I
G
C
I
L
F
E
Y
Y
R
G
F
T
L
F
-
Q
T
H
E
-----
N
R
E
H
L
V
M
M
E
K
I
L
G
P
I
P
S
H
M
I
H
R
-
T
R
--
K
Q
-
K
Y
F
Y
K
G
-----
G
L
V
W
D
E
N
-------------
S
S
D
----
G
R
----
Y
V
K
--
E
-
N
C
K
P
L
K
S
Y
M
LQD---
S
-------
L
E
-
H
V
Q
------------------
L
F
D
L
M
R
R
M
L
E
F
D
P
A
Q
R
I
T
L
A
E
A
L
L
H
P
F
F
---
A
G
L
T
P
E
E
R
S
-
F
H
----------------------------------------------------------------------------------------------------------
78
HHSearch
69.00
33%
-110
- C1 -
4IIR
1
PRP4B_HUMAN
A:
[13-350]
-------------------------------------------------------------------------------------
W
T
D
A
E
G
Y
Y
R
V
N
I
G
E
V
L
D
K
R
Y
N
V
Y
G
Y
T
G
Q
G
--
S
N
V
V
R
A
R
D
N
A
R
-
A
N
Q
E
V
A
V
K
I
I
R
N
N
E
L
M
Q
K
T
G
L
K
E
L
E
F
L
K
K
L
N
D
A
D
P
D
D
K
-------
F
H
C
L
R
L
F
R
H
F
Y
H
K
Q
----
H
L
C
L
V
F
E
P
L
S
M
N
L
R
E
V
L
K
K
Y
G
K
D
V
G
L
H
I
K
A
V
R
S
Y
S
Q
Q
L
F
L
A
L
K
L
L
K
R
C
-
N
--
I
L
H
A
D
I
K
P
D
N
I
L
--------
V
-----------------------
N
E
S
-----------------------
K
------------------
T
--------------
I
L
K
L
C
D
F
G
S
A
S
H
V
A
D
N
D
I
T
P
Y
L
V
S
R
F
Y
R
A
P
E
I
I
I
G
K
S
Y
D
Y
G
I
D
M
W
S
V
G
C
T
L
Y
E
L
Y
T
G
K
I
L
F
-
P
G
K
T
-----
N
N
H
M
L
K
L
A
M
D
L
K
G
K
M
P
N
K
M
I
R
K
G
V
F
--
K
D
-
Q
H
F
D
Q
N
-----
L
N
F
M
Y
I
E
---------------
R
----
E
K
V
T
V
M
S
T
I
--
N
-
P
T
K
D
L
L
A
D
L
IL
P
E
D
Q
R
-------
K
K
-
V
H
Q
------------------
L
K
D
L
L
D
Q
I
L
M
L
D
P
A
K
R
I
S
I
N
Q
A
L
Q
H
A
F
I
Q
E
-----------------------------------------------------------------------------------------------------------------------
76
HHSearch
68.14
35%
-112
- C1 -
1Z57
1
CLK1_HUMAN
A:
[10-336]
--------------------------------------------------------------------------------------------------
D
V
L
S
A
R
Y
E
I
V
D
T
L
G
E
G
A
F
G
K
V
V
E
C
I
D
H
-
K
A
G
G
R
H
V
A
V
K
I
V
K
N
V
D
R
Y
C
E
A
A
R
S
E
I
Q
V
L
E
H
L
N
T
T
D
P
N
S
T
-------
F
R
C
V
Q
M
L
E
W
F
E
H
H
G
----
H
I
C
I
V
F
E
L
L
G
L
S
T
Y
D
F
I
K
E
N
G
-
F
L
P
F
R
L
D
H
I
R
K
M
A
Y
Q
I
C
K
S
V
N
F
L
H
S
N
-
K
--
L
T
H
T
D
L
K
P
E
N
I
L
--------
F
-----------------------
V
Q
S
-----------------------
D
Y
T
E
A
Y
NR
D
E
R
T
L
I----
N
P
--------------
D
I
K
V
V
D
F
G
S
A
T
Y
D
-
D
E
H
H
S
T
L
V
S
T
R
H
Y
R
A
P
E
V
I
L
A
L
G
W
S
Q
P
C
D
V
W
S
I
G
C
I
L
I
E
Y
Y
L
G
F
T
V
F
-
P
T
H
D
-----
S
K
E
H
L
A
M
M
E
R
I
L
G
P
L
P
K
H
M
I
Q
K
T
R
K
--
R
K
-
Y
F
H
H
D
------
R
L
D
W
D
E
H
-------------
S
S
A
----
G
R
----
Y
V
S
--
R
-
A
C
K
P
L
K
E
F
M
LSQ---
D
-------
V
E
-
H
E
R
------------------
L
F
D
L
I
Q
K
M
L
E
Y
D
P
A
K
R
I
T
L
R
E
A
L
K
H
P
F
F
D
L
L
K
K
--------------------------------------------------------------------------------------------------------------------
51
PsiBlast_CBE
68.14
31%
-110
- C1 -
3NR9
1
CLK2_HUMAN
A:
[17-356]
--------------------------------------------------------------------------------------
D
D
A
E
G
H
L
I
Y
H
V
G
D
W
L
Q
E
R
Y
E
I
V
S
T
L
G
E
G
T
F
G
R
V
V
Q
C
V
D
H
-
R
R
G
G
A
R
V
A
L
K
I
I
K
N
V
E
K
Y
K
E
A
A
R
L
E
I
N
V
L
E
K
I
N
E
K
D
P
D
N
K
-------
N
L
C
V
Q
M
F
D
W
F
D
Y
H
G
----
H
M
C
I
S
F
E
L
L
G
L
S
T
F
D
F
L
K
D
N
N
-
Y
L
P
Y
P
I
H
Q
V
R
H
M
A
F
Q
L
C
Q
A
V
K
F
L
H
D
N
-
K
--
L
T
H
T
D
L
K
P
E
N
I
L
--------
F
-----------------------
V
N
S
-----------------------
D
Y
E
L
TD
E
R
S
V
K-------
S
T
--------------
A
V
R
V
V
D
F
G
S
A
T
F
D
-
H
E
H
H
S
T
I
V
S
T
R
H
Y
R
A
P
E
V
I
L
E
L
G
W
S
Q
P
C
D
V
W
S
I
G
C
I
I
F
E
Y
Y
V
G
F
T
L
F
-
Q
T
H
D
-----
N
R
E
H
L
A
M
M
E
R
I
L
G
P
I
P
S
R
M
I
R
K
T
R
K
--
Q
K
-
Y
F
Y
R
G
R
--------
L
D
W
D
-------------
E
N
T
----
S
A
----
G
R
Y
-----
V
R
E
N
C
K
P
L
------
R
-------
R
Y
-
L
T
S
EA
E
E
H
H
Q
-----------
L
F
D
L
I
E
S
M
L
E
Y
E
P
A
K
R
L
T
L
G
E
A
L
Q
H
P
F
F
A
R
L
R
A
--------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
68.05
33%
-106
- C1 -
2WU7
1
CLK3_HUMAN
A:
[32-377]
-----------------------------------------------------------------------------------
S
V
E
D
D
K
E
G
H
L
V
C
R
I
G
D
W
L
Q
E
R
Y
E
I
V
G
N
L
G
E
G
T
F
G
K
V
V
E
C
L
D
H
A
R
-
G
K
S
Q
V
A
L
K
I
I
R
N
V
G
K
Y
R
E
A
A
R
L
E
I
N
V
L
K
K
I
K
E
K
D
K
E
N
K
-------
F
L
C
V
L
M
S
D
W
F
N
F
H
G
----
H
M
C
I
A
F
E
L
L
G
K
N
T
F
E
F
L
K
E
N
N
-
F
Q
P
Y
P
L
P
H
V
R
H
M
A
Y
Q
L
C
H
A
L
R
F
L
H
E
N
-
Q
--
L
T
H
T
D
L
K
P
E
N
I
L
F
VNS
E
F
E
T
L
-----------------------
Y
N
E
-----------------------
H
-----------------
K
S
C
E
E
K
S
V
KNT-----
S
I
R
V
A
D
F
G
S
A
T
F
D
-
H
E
H
H
T
T
I
V
A
T
R
H
Y
R
P
P
E
V
I
L
E
L
G
W
A
Q
P
C
D
V
W
S
I
G
C
I
L
F
E
Y
Y
R
G
F
T
L
F
-
Q
T
H
E
-----
N
R
E
H
L
V
M
M
E
K
I
L
G
P
I
P
S
H
M
I
H
R
-
T
R
--
K
Q
-
K
Y
F
Y
K
G
-----
G
L
V
W
D
E
N
-------------
S
S
D
----
G
R
----
Y
V
K
--
E
-
N
C
K
P
L
K
S
Y
M
LQD---
S
-------
L
E
-
H
V
Q
------------------
L
F
D
L
M
R
R
M
L
E
F
D
P
A
Q
R
I
T
L
A
E
A
L
L
H
P
F
F
---
A
G
L
T
P
E
E
R
S
-
F
-----------------------------------------------------------------------------------------------------------
47
PsiBlast_CBE
68.00
33%
-105
- C1 -
3RAW
1
CLK3_HUMAN
B:
[33-377]
------------------------------------------------------------------------------------
V
E
D
D
K
E
G
H
L
V
C
R
I
G
D
W
L
Q
E
R
Y
E
I
V
G
N
L
G
E
G
T
F
G
K
V
V
E
C
L
D
H
A
R
-
G
K
S
Q
V
A
L
K
I
I
R
N
V
G
K
Y
R
E
A
A
R
L
E
I
N
V
L
K
K
I
K
E
K
D
K
E
N
K
-------
F
L
C
V
L
M
S
D
W
F
N
F
H
G
----
H
M
C
I
A
F
E
L
L
G
K
N
T
F
E
F
L
K
E
N
N
-
F
Q
P
Y
P
L
P
H
V
R
H
M
A
Y
Q
L
C
H
A
L
R
F
L
H
E
N
-
Q
--
L
T
H
T
D
L
K
P
E
N
I
L
FVNS
E
F
E
T
L
-----------------------
Y
N
E
-----------------------
H
-----------------
K
S
C
E
E
K
S
V
KNT-----
S
I
R
V
A
D
F
G
S
A
T
F
D
-
H
E
H
H
T
T
I
V
A
T
R
H
Y
R
P
P
E
V
I
L
E
L
G
W
A
Q
P
C
D
V
W
S
I
G
C
I
L
F
E
Y
Y
R
G
F
T
L
F
-
Q
T
H
E
-----
N
R
E
H
L
V
M
M
E
K
I
L
G
P
I
P
S
H
M
I
H
R
-
T
R
--
K
Q
-
K
Y
F
Y
K
G
-----
G
L
V
W
D
E
N
-------------
S
S
D
----
G
R
----
Y
V
K
--
E
-
N
C
K
P
L
K
S
Y
M
LQD---
S
-------
L
E
-
H
V
Q
------------------
L
F
D
L
M
R
R
M
L
E
F
D
P
A
Q
R
I
T
L
A
E
A
L
L
H
P
F
F
---
A
G
L
T
P
E
E
R
S
-
F
H
T
---------------------------------------------------------------------------------------------------------
52
PsiBlast_CBE
67.97
33%
-115
- C1 -
1Z57
1
CLK1_HUMAN
A:
[10-329]
--------------------------------------------------------------------------------------------------
D
V
L
S
A
R
Y
E
I
V
D
T
L
G
E
G
A
F
G
K
V
V
E
C
I
D
H
-
K
A
G
G
R
H
V
A
V
K
I
V
K
N
V
D
R
Y
C
E
A
A
R
S
E
I
Q
V
L
E
H
L
N
T
T
D
P
N
S
T
-------
F
R
C
V
Q
M
L
E
W
F
E
H
H
G
----
H
I
C
I
V
F
E
L
L
G
L
S
T
Y
D
F
I
K
E
N
G
-
F
L
P
F
R
L
D
H
I
R
K
M
A
Y
Q
I
C
K
S
V
N
F
L
H
S
N
-
K
--
L
T
H
T
D
L
K
P
E
N
I
L
--------
F
-----------------------
V
Q
S
-----------------------
D
-----------------
Y
T
E
A
Y
NR
D
E
R
T
L
INP-
D
I
K
V
V
D
F
G
S
A
T
Y
D
-
D
E
H
H
S
T
L
V
S
T
R
H
Y
R
A
P
E
V
I
L
A
L
G
W
S
Q
P
C
D
V
W
S
I
G
C
I
L
I
E
Y
Y
L
G
F
T
V
F
-
P
T
H
D
-----
S
K
E
H
L
A
M
M
E
R
I
L
G
P
L
P
K
H
M
I
Q
-
K
T
R
--
K
R
-
K
Y
F
H
H
D
-----
R
L
D
W
D
E
H
-------------
S
S
A
----
G
R
----
Y
V
S
--
R
-
A
C
K
P
L
K
E
F
M
------
L
-------
S
Q
-
D
V
E
H
E
R
---------------
L
F
D
L
I
Q
K
M
L
E
Y
D
P
A
K
R
I
T
L
R
E
A
L
K
H
P
F
F
D
L
L
K
K
--------------------------------------------------------------------------------------------------------------------
50
PsiBlast_CBE
67.42
31%
-113
- C1 -
3NR9
1
CLK2_HUMAN
B:
[17-354]
--------------------------------------------------------------------------------------
D
D
A
E
G
H
L
I
Y
H
V
G
D
W
L
Q
E
R
Y
E
I
V
S
T
L
G
E
G
T
F
G
R
V
V
Q
C
V
D
H
-
R
R
G
G
A
R
V
A
L
K
I
I
K
N
V
E
K
Y
K
E
A
A
R
L
E
I
N
V
L
E
K
I
N
E
K
D
P
D
N
K
-------
N
L
C
V
Q
M
F
D
W
F
D
Y
H
G
----
H
M
C
I
S
F
E
L
L
G
L
S
T
F
D
F
L
K
D
N
N
-
Y
L
P
Y
P
I
H
Q
V
R
H
M
A
F
Q
L
C
Q
A
V
K
F
L
H
D
N
-
K
--
L
T
H
T
D
L
K
P
E
N
I
L
--------
F
-----------------------
V
N
S
-----------------------
D
Y
E
L
T
Y
NLEKK
R
D
E
R
S
V
K
S
T
--------------
A
V
R
V
V
D
F
G
S
A
T
F
D
-
H
E
H
H
S
T
I
V
S
T
R
H
Y
R
A
P
E
V
I
L
E
L
G
W
S
Q
P
C
D
V
W
S
I
G
C
I
I
F
E
Y
Y
V
G
F
T
L
F
-
Q
T
H
D
-----
N
R
E
H
L
A
M
M
E
R
I
L
G
P
I
P
S
R
M
I
R
K
T
R
K
--
Q
K
-
Y
F
Y
R
G
R
--------
L
D
W
D
-------------
E
N
T
----
S
A
----
G
R
Y
-----
V
R
E
N
C
K
P
L
------
R
-------
R
Y
-
L
T
S
EA
E
E
H
H
Q
-----------
L
F
D
L
I
E
S
M
L
E
Y
E
P
A
K
R
L
T
L
G
E
A
L
Q
H
P
F
F
A
R
L
----------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
67.00
33%
-103
- C1 -
3RAW
1
CLK3_HUMAN
A:
[31-377]
----------------------------------------------------------------------------------
R
S
V
E
D
D
K
E
G
H
L
V
C
R
I
G
D
W
L
Q
E
R
Y
E
I
V
G
N
L
G
E
G
T
F
G
K
V
V
E
C
L
D
H
A
R
-
G
K
S
Q
V
A
L
K
I
I
R
N
V
G
K
Y
R
E
A
A
R
L
E
I
N
V
L
K
K
I
K
E
K
D
K
E
N
K
-------
F
L
C
V
L
M
S
D
W
F
N
F
H
G
----
H
M
C
I
A
F
E
L
L
G
K
N
T
F
E
F
L
K
E
N
N
-
F
Q
P
Y
P
L
P
H
V
R
H
M
A
Y
Q
L
C
H
A
L
R
F
L
H
E
N
-
Q
--
L
T
H
T
D
L
K
P
E
N
I
L
FVNS
E
F
E
T
L
-----------------------
Y
N
E
-----------------------
H
-----------------
K
S
C
E
E
K
S
V
KNT-----
S
I
R
V
A
D
F
G
S
A
T
F
D
-
H
E
H
H
T
T
I
V
A
T
R
H
Y
R
P
P
E
V
I
L
E
L
G
W
A
Q
P
C
D
V
W
S
I
G
C
I
L
F
E
Y
Y
R
G
F
T
L
F
-
Q
T
H
E
-----
N
R
E
H
L
V
M
M
E
K
I
L
G
P
I
P
S
H
M
I
H
R
-
T
R
--
K
Q
-
K
Y
F
Y
K
G
-----
G
L
V
W
D
E
N
-------------
S
S
D
----
G
R
----
Y
V
K
--
E
-
N
C
K
P
L
K
S
Y
M
LQD---
S
-------
L
E
-
H
V
Q
------------------
L
F
D
L
M
R
R
M
L
E
F
D
P
A
Q
R
I
T
L
A
E
A
L
L
H
P
F
F
---
A
G
L
T
P
E
E
R
S
-
F
H
T
---------------------------------------------------------------------------------------------------------
49
PsiBlast_CBE
66.67
31%
-110
- C1 -
3NR9
1
CLK2_HUMAN
C:
[17-355]
--------------------------------------------------------------------------------------
D
D
A
E
G
H
L
I
Y
H
V
G
D
W
L
Q
E
R
Y
E
I
V
S
T
L
G
E
G
T
F
G
R
V
V
Q
C
V
D
H
-
R
R
G
G
A
R
V
A
L
K
I
I
K
N
V
E
K
Y
K
E
A
A
R
L
E
I
N
V
L
E
K
I
N
E
K
D
P
D
N
K
-------
N
L
C
V
Q
M
F
D
W
F
D
Y
H
G
----
H
M
C
I
S
F
E
L
L
G
L
S
T
F
D
F
L
K
D
N
N
-
Y
L
P
Y
P
I
H
Q
V
R
H
M
A
F
Q
L
C
Q
A
V
K
F
L
H
D
N
-
K
--
L
T
H
T
D
L
K
P
E
N
I
L
--------
F
-----------------------
V
N
S
-----------------------
D
YELTYNLEKKRDERSVK
S
T
--------------
A
V
R
V
V
D
F
G
S
A
T
F
D
-
H
E
H
H
S
T
I
V
S
T
R
H
Y
R
A
P
E
V
I
L
E
L
G
W
S
Q
P
C
D
V
W
S
I
G
C
I
I
F
E
Y
Y
V
G
F
T
L
F
-
Q
T
H
D
-----
N
R
E
H
L
A
M
M
E
R
I
L
G
P
I
P
S
R
M
I
R
K
T
R
K
--
Q
K
-
Y
F
Y
R
G
R
--------
L
D
W
D
-------------
E
N
T
----
S
A
----
G
R
Y
-----
V
R
E
N
C
K
P
L
------
R
-------
R
Y
-
L
T
S
EAEEHHQ-----------
L
F
D
L
I
E
S
M
L
E
Y
E
P
A
K
R
L
T
L
G
E
A
L
Q
H
P
F
F
A
R
L
R
---------------------------------------------------------------------------------------------------------------------
53
PsiBlast_CBE
66.54
33%
-114
- C1 -
2VAG
1
CLK1_HUMAN
A:
[10-329]
--------------------------------------------------------------------------------------------------
D
V
L
S
A
R
Y
E
I
V
D
T
L
G
E
G
A
F
G
K
V
V
E
C
I
D
H
-
K
A
G
G
R
H
V
A
V
K
I
V
K
N
V
D
R
Y
C
E
A
A
R
S
E
I
Q
V
L
E
H
L
N
T
T
D
P
N
S
T
-------
F
R
C
V
Q
M
L
E
W
F
E
H
H
G
----
H
I
C
I
V
F
E
L
L
G
L
S
T
Y
D
F
I
K
E
N
G
-
F
L
P
F
R
L
D
H
I
R
K
M
A
Y
Q
I
C
K
S
V
N
F
L
H
S
N
-
K
--
L
T
H
T
D
L
K
P
E
N
I
L
--------
F
-----------------------
V
Q
S
-----------------------
D
-----------------
Y
T
E
A
Y
NK
R
D
E
R
T
L
INP
D
I
K
V
V
D
F
G
S
A
T
Y
D
-
D
E
H
H
S
T
L
V
S
T
R
H
Y
R
A
P
E
V
I
L
A
L
G
W
S
Q
P
C
D
V
W
S
I
G
C
I
L
I
E
Y
Y
L
G
F
T
V
F
-
P
T
H
D
-----
S
K
E
H
L
A
M
M
E
R
I
L
G
P
L
P
K
H
M
I
Q
-
K
T
R
--
K
R
-
K
Y
F
H
H
D
-----
R
L
D
W
D
E
H
-------------
S
S
A
----
G
R
----
Y
V
S
--
R
-
A
C
K
P
L
K
E
F
M
------
L
-------
S
Q
-
D
V
E
H
E
R
---------------
L
F
D
L
I
Q
K
M
L
E
Y
D
P
A
K
R
I
T
L
R
E
A
L
K
H
P
F
F
D
L
L
K
---------------------------------------------------------------------------------------------------------------------
54
PsiBlast_CBE
65.69
31%
-106
- C1 -
3LLT
1
?
A:
[39-359]
----------------------------------------------------------------------------------------------------------
V
I
R
K
M
G
D
G
T
F
G
R
V
L
L
C
Q
H
I
-
D
-
N
K
K
Y
Y
A
V
K
V
V
R
N
I
K
K
Y
T
R
S
A
K
I
E
A
D
I
L
K
K
I
Q
N
D
D
I
N
N
N
-------
N
I
V
K
Y
H
G
K
F
M
Y
Y
-
D
----
H
M
C
L
I
F
E
P
L
G
P
S
L
Y
E
I
I
T
R
N
N
-
Y
N
G
F
H
I
E
D
I
K
L
Y
C
I
E
I
L
K
A
L
N
Y
L
R
K
M
-
S
--
L
T
H
T
D
L
K
P
E
N
I
L
--------
L
DDPYF
E
K
S
L
I
T
V
R
R
VTDG
K
K
I
Q
I
Y
R
T
-----------------------
K
-----------------
S
T
--------------
G
I
K
L
I
D
F
G
C
A
T
F
K
-
S
D
Y
H
G
S
I
I
N
T
R
Q
Y
R
A
P
E
V
I
L
N
L
G
W
D
V
S
S
D
M
W
S
F
G
C
V
L
A
E
L
Y
T
G
S
L
L
F
-
R
T
H
E
-----
H
M
E
H
L
A
M
M
E
S
I
I
Q
P
I
P
K
N
M
L
Y
E
A
T
K
--
T
N
G
S
K
Y
V
N
K
DELKL
A
W
P
E
N
A
S
-------------
S
I
N
----
S
I
----
K
H
V
--
K
-
K
C
L
P
L
Y
K
I
I
------
K
----------
H
E
L
------------------
F
C
D
F
L
Y
S
I
L
Q
I
D
P
T
L
R
P
S
P
A
E
L
L
K
H
K
F
L
E
------------------------------------------------------------------------------------------------------------------------
60
PsiBlast_CBE
64.47
31%
-94
- C1 -
1Q8Y
1
?
B:
[20-362]
-------------------------------------------------------------------------------------------------------
R
Y
I
L
V
R
K
L
G
---
F
S
T
V
W
L
A
K
D
M
-
V
-
N
N
T
H
V
A
M
K
I
V
R
G
D
K
V
Y
T
E
A
A
E
D
E
I
K
L
L
Q
--
R
V
N
D
A
D
N
T
K
E
D
S
M
G
A
N
H
I
L
K
L
L
D
H
F
N
H
K
G
PN
G
V
H
V
V
M
V
F
E
V
L
G
E
N
L
L
A
L
I
K
K
Y
E
-
H
R
G
I
P
L
I
Y
V
K
Q
I
S
K
Q
L
L
L
G
L
D
Y
M
H
R
R
C
G
--
I
I
H
T
D
I
K
P
E
N
V
L
--------
M
E
I
VD-------------------
S
P
E
-----------------------
N
-----------------
L
I
--------------
Q
I
K
I
A
D
L
G
N
A
C
W
Y
-
D
E
H
Y
T
N
S
I
Q
T
R
E
Y
R
S
P
E
V
L
L
G
A
P
W
G
C
G
A
D
I
W
S
T
A
C
L
I
F
E
L
I
T
G
D
F
L
F
E
P
D
E
G
HSYT
K
D
D
D
H
I
A
Q
I
I
E
L
L
G
E
L
P
S
Y
L
L
R
N
G
K
Y
--
T
R
-
T
F
F
N
S
R
-----
G
L
L
R
N
I
S
-------------
K
-------
L
----
K
F
W
--
P
-
L
E
D
V
L
T
E
K
Y
------
K
F------
S
K
-
D
E
A
K
E
----------------
I
S
D
F
L
S
P
M
L
Q
L
D
P
R
K
R
A
D
A
G
G
L
V
N
H
P
W
L
K
D
T
L
G
M
E
E
I
R
V
P
D
R
E
L
Y
G
S
G
S
D
I
P
G
W
F
E
E
V
R
------------------------------------------------------------------------------------------
86
HHSearch
64.27
32%
-123
- C1 -
4BGQ
3
CDKL5_HUMAN
A:
[12-302]
------------------------------------------------------------------------------------------------------
N
K
F
E
I
L
G
V
V
G
E
G
A
Y
G
V
V
L
K
C
R
H
K
-
E
-
T
H
E
I
V
A
I
K
K
F
K
----
V
K
E
T
T
L
R
E
L
K
M
L
R
T
L
K
------
Q
-------
E
N
I
V
E
L
K
E
A
F
R
R
R
G
----
K
L
Y
L
V
F
E
Y
V
E
K
N
M
L
E
L
L
E
E
M
P
--
N
G
V
P
P
E
K
V
K
S
Y
I
Y
Q
L
I
K
A
I
H
W
C
H
K
N
-
D
--
I
V
H
R
D
I
K
P
E
N
L
L
--------
I
-----------------------
S
H
N
-----------------------
D
---------------------------------
V
L
K
L
C
D
F
G
F
A
R
N
L
-
S
E
-------
T
R
W
Y
R
S
P
E
L
L
L
G
A
P
Y
G
K
S
V
D
M
W
S
V
G
C
I
L
G
E
L
S
D
G
Q
P
L
F
-
P
G
E
S
-----
E
I
D
Q
L
F
T
I
Q
K
V
L
G
P
L
P
S
E
Q
M
K
L
F
Y
S
--
N
P
--
R
F
H
G
L
-----
R
F
P
A
V
N
-----------------------------
H
--
P
-
Q
S
L
E
-
R
R
Y
L
------
G
-------
I
L
-
N
S
V
------------------
L
L
D
L
M
K
N
L
L
K
L
D
P
A
D
R
Y
L
T
E
Q
C
L
N
H
P
T
F
Q
T
Q
R
L
--------------------------------------------------------------------------------------------------------------------
79
HHSearch
64.26
32%
-105
- C1 -
3LLT
1
?
A:
[20-360]
---------------------------------------------------------------------------------------
D
E
I
V
H
F
S
W
K
K
G
M
L
L
N
N
A
F
L
V
I
R
K
M
G
D
G
T
F
G
R
V
L
L
C
Q
H
I
-
D
-
N
K
K
Y
Y
A
V
K
V
V
R
N
I
K
K
Y
T
R
S
A
K
I
E
A
D
I
L
K
K
I
Q
N
D
D
-
I
N
N
-------
N
N
I
V
K
Y
H
G
K
F
M
Y
Y
D
----
H
M
C
L
I
F
E
P
L
G
P
S
L
Y
E
I
I
T
R
N
N
-
Y
N
G
F
H
I
E
D
I
K
L
Y
C
I
E
I
L
K
A
L
N
Y
L
R
K
M
-
S
--
L
T
H
T
D
L
K
P
E
N
I
L
--------
L
-----------------------
D
D
P
YF
E
K
S
L
I
T
V
R
R
VTDG
K
K
I
Q
I
Y
R
T
K
-----------------
S
T
--------------
G
I
K
L
I
D
F
G
C
A
T
F
K
-
S
D
Y
H
G
S
I
I
N
T
R
Q
Y
R
A
P
E
V
I
L
N
L
G
W
D
V
S
S
D
M
W
S
F
G
C
V
L
A
E
L
Y
T
G
S
L
L
F
-
R
T
H
E
-----
H
M
E
H
L
A
M
M
E
S
I
I
Q
P
I
P
K
N
M
L
Y
E
A
T
K
T
N
G
S
-
K
Y
V
N
K
D
-----
E
L
K
L
A
W
P
-------------
E
N
A
---------------
S
-
S
I
N
S
I
K
H
V
K
------
K
CLP
L
Y
K
I
I
K
-
H
E
L
------------------
F
C
D
F
L
Y
S
I
L
Q
I
D
P
T
L
R
P
S
P
A
E
L
L
K
H
K
F
L
E
------------------------------------------------------------------------------------------------------------------------
57
PsiBlast_CBE
62.42
31%
-89
- C1 -
1Q97
1
?
B:
[20-362]
-------------------------------------------------------------------------------------------------------
R
Y
I
L
V
R
K
L
G
W
G
H
F
S
T
V
W
L
A
K
D
M
-
V
-
N
N
T
H
V
A
M
K
I
V
R
G
D
K
V
Y
T
E
A
A
E
D
E
I
K
L
L
Q
--
R
V
N
D
A
D
N
T
K
E
D
S
M
G
A
N
H
I
L
K
L
L
D
H
F
N
H
K
G
PN
G
V
H
V
V
M
V
F
E
V
L
G
E
N
L
L
A
L
I
K
K
Y
E
-
H
R
G
I
P
L
I
Y
V
K
Q
I
S
K
Q
L
L
L
G
L
D
Y
M
H
R
R
C
G
--
I
I
H
T
D
I
K
P
E
N
V
L
--------
M
E
I
VD-------------------
S
P
E
-----------------------
N
-----------------
L
I
--------------
Q
I
K
I
A
D
L
G
N
A
C
W
Y
-
D
E
H
Y
T
N
S
I
Q
T
R
E
Y
R
S
P
E
V
L
L
G
A
P
W
G
C
G
A
D
I
W
S
T
A
C
L
I
F
E
L
I
T
G
D
F
L
F
E
P
D
E
G
HSYT
K
D
D
D
H
I
A
Q
I
I
E
L
L
G
E
L
P
S
Y
L
L
R
N
G
K
Y
--
T
R
-
T
F
F
N
S
R
-----
G
L
L
R
N
I
S
-------------
K
-------
L
----
K
F
W
--
P
-
L
E
D
V
L
T
E
K
Y
------
K
F------
S
K
-
D
E
A
K
E
----------------
I
S
D
F
L
S
P
M
L
Q
L
D
P
R
K
R
A
D
A
G
G
L
V
N
H
P
W
L
K
D
T
L
G
M
E
E
I
R
V
P
D
R
E
L
Y
G
S
G
S
D
I
P
G
W
F
E
E
V
R
------------------------------------------------------------------------------------------
55
PsiBlast_CBE
61.24
31%
-89
- C1 -
1Q99
2
SKY1_YEAST
B:
[20-362]
-------------------------------------------------------------------------------------------------------
R
Y
I
L
V
R
K
L
G
W
G
H
F
S
T
V
W
L
A
K
D
M
-
V
-
N
N
T
H
V
A
M
K
I
V
R
G
D
K
V
Y
T
E
A
A
E
D
E
I
K
L
L
Q
--
R
V
N
D
A
D
N
T
K
E
D
S
M
G
A
N
H
I
L
K
L
L
D
H
F
N
H
K
G
PN
G
V
H
V
V
M
V
F
E
V
L
G
E
N
L
L
A
L
I
K
K
Y
E
-
H
R
G
I
P
L
I
Y
V
K
Q
I
S
K
Q
L
L
L
G
L
D
Y
M
H
R
R
C
G
--
I
I
H
T
D
I
K
P
E
N
V
L
--------
M
E
I
VD-------------------
S
P
E
-----------------------
N
-----------------
L
I
--------------
Q
I
K
I
A
D
L
G
N
A
C
W
Y
-
D
E
H
Y
T
N
S
I
Q
T
R
E
Y
R
S
P
E
V
L
L
G
A
P
W
G
C
G
A
D
I
W
S
T
A
C
L
I
F
E
L
I
T
G
D
F
L
F
E
P
D
E
G
HSYT
K
D
D
D
H
I
A
Q
I
I
E
L
L
G
E
L
P
S
Y
L
L
R
N
G
K
Y
--
T
R
-
T
F
F
N
S
R
-----
G
L
L
R
N
I
S
-------------
K
-------
L
----
K
F
W
--
P
-
L
E
D
V
L
T
E
K
Y
------
K
F------
S
K
-
D
E
A
K
E
----------------
I
S
D
F
L
S
P
M
L
Q
L
D
P
R
K
R
A
D
A
G
G
L
V
N
H
P
W
L
K
D
T
L
G
M
E
E
I
R
V
P
D
R
E
L
Y
G
S
G
S
D
I
P
G
W
F
E
E
V
R
------------------------------------------------------------------------------------------
63
PsiBlast_CBE
60.71
31%
-93
- C1 -
1HOW
2
SKY1_YEAST
A:
[20-362]
-------------------------------------------------------------------------------------------------------
R
Y
I
L
V
R
K
L
G
W
G
H
F
S
T
V
W
L
A
K
D
M
-
V
-
N
N
T
H
V
A
M
K
I
V
R
G
D
K
V
Y
T
E
A
A
E
D
E
I
K
L
L
Q
--
R
V
N
D
A
D
N
T
K
E
D
S
M
GA
N
H
I
L
K
L
L
D
H
F
N
H
K
G
PN
G
V
H
V
V
M
V
F
E
V
L
G
E
N
L
L
A
L
I
K
K
Y
E
-
H
R
G
I
P
L
I
Y
V
K
Q
I
S
K
Q
L
L
L
G
L
D
Y
M
H
R
R
C
G
--
I
I
H
T
D
I
K
P
E
N
V
L
--------
M
E
I
VD-------------------
S
P
E
-----------------------
N
-----------------
L
I
--------------
Q
I
K
I
A
D
L
G
N
A
C
W
Y
-
D
E
H
Y
T
N
S
I
Q
T
R
E
Y
R
S
P
E
V
L
L
G
A
P
W
G
C
G
A
D
I
W
S
T
A
C
L
I
F
E
L
I
T
G
D
F
L
F
E
P
D
-------
D
D
D
H
I
A
Q
I
I
E
L
L
G
E
L
P
S
Y
L
L
R
N
G
K
Y
--
T
R
-
T
F
F
--------------
S
-------------
K
-------
L
----
K
F
W
--
P
-
L
E
D
V
L
T
E
K
Y
------
K
F------
S
K
-
D
E
A
K
E
----------------
I
S
D
F
L
S
P
M
L
Q
L
D
P
R
K
R
A
D
A
G
G
L
V
N
H
P
W
L
K
D
T
L
G
M
E
E
I
R
V
P
D
R
E
L
Y
G
S
G
S
D
I
P
G
W
F
E
E
V
R
------------------------------------------------------------------------------------------
56
PsiBlast_CBE
60.70
31%
-92
- C1 -
1Q99
2
SKY1_YEAST
A:
[20-362]
-------------------------------------------------------------------------------------------------------
R
Y
I
L
V
R
K
L
G
W
G
H
F
S
T
V
W
L
A
K
D
M
-
V
-
N
N
T
H
V
A
M
K
I
V
R
G
D
K
V
Y
T
E
A
A
E
D
E
I
K
L
L
Q
--
R
V
N
D
A
D
N
T
K
E
D
S
M
G
A
N
H
I
L
K
L
L
D
H
F
N
H
K
G
PN
G
V
H
V
V
M
V
F
E
V
L
G
E
N
L
L
A
L
I
K
K
Y
E
-
H
R
G
I
P
L
I
Y
V
K
Q
I
S
K
Q
L
L
L
G
L
D
Y
M
H
R
R
C
G
--
I
I
H
T
D
I
K
P
E
N
V
L
--------
M
E
I
VD-------------------
S
P
E
-----------------------
N
-----------------
L
I
--------------
Q
I
K
I
A
D
L
G
N
A
C
W
Y
-
D
E
H
Y
T
N
S
I
Q
T
R
E
Y
R
S
P
E
V
L
L
G
A
P
W
G
C
G
A
D
I
W
S
T
A
C
L
I
F
E
L
I
T
G
D
F
L
F
E----T
K
---
D
D
D
H
I
A
Q
I
I
E
L
L
G
E
L
P
S
Y
L
L
R
N
G
K
Y
--
T
R
-
T
F
F
N
S
-------
L
L
R
N
I
S
-------------
K
-------
L
----
K
F
W
--
P
-
L
E
D
V
L
T
E
K
Y
------
K
F------
S
K
-
D
E
A
K
E
----------------
I
S
D
F
L
S
P
M
L
Q
L
D
P
R
K
R
A
D
A
G
G
L
V
N
H
P
W
L
K
D
T
L
G
M
E
E
I
R
V
P
D
R
E
L
Y
G
S
G
S
D
I
P
G
W
F
E
E
V
R
------------------------------------------------------------------------------------------
13
PsiBlast_PDB
60.44
44%
-84
- C1 -
4YLK
13
DYR1A_HUMAN
A:
[34-357]
-------------------------------------------------------------------------------------------------------
R
Y
E
I
D
S
L
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
R
-
V
-
E
Q
E
W
V
A
I
K
I
I
K
N
K
K
A
F
L
N
Q
A
Q
I
E
V
R
L
L
E
L
M
N
K
H
D
T
E
M
K
-------
Y
Y
I
V
H
L
K
R
H
F
M
F
R
N
----
H
L
C
L
V
F
E
M
L
S
Y
N
L
Y
D
L
L
R
N
T
N
-
F
R
G
V
S
L
N
L
T
R
K
F
A
Q
Q
M
C
T
A
L
L
F
L
A
T
P
-
E
LS
I
I
H
C
D
L
K
P
E
N
I
L
--------
L
-----------------------
C
N
P
-----------------------
K
-----------------
R
S
--------------
A
I
K
I
V
D
F
G
S
S
C
Q
L
-
G
Q
R
I
Y
Q
Y
I
Q
S
R
F
Y
R
S
P
E
V
L
L
G
M
P
Y
D
L
A
I
D
M
W
S
L
G
C
I
L
V
E
M
H
T
G
E
P
L
F
-
S
G
A
N
-----
E
V
D
Q
M
N
K
I
V
E
V
L
G
I
P
P
A
H
I
L
D
Q
A
P
K
--
A
R
-
K
F
F
E
K
-------
L
P
D
G
T
W
-------------
N
L
K
K----------
E
Y
KP
P
-
G
T
R
K
L
H
N
I
L
------
G
-------
V
E
-
T
G
G
PGGRRAGESGH
T
V
A
D
Y
L
K
F
K
D
L
I
L
R
M
L
D
Y
D
P
K
T
R
I
Q
P
Y
Y
A
L
Q
H
S
F
F
K
K
-----------------------------------------------------------------------------------------------------------------------