@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : E2AK2_HUMAN: (2015-10-06 )
MAGDLSAGFFMEELNTYRQKQGVVLKYQELPNSGPPHDRRFTFQVIIDGREFPEGEGRSKKEAKNAAAKLAVEILNKEKKAVSPLLLTTTNSSEGLSMGNYIGLINRIAQKKRLTVNYEQCASGVHGPEGFHYKCKMGQKEYSIGTGSTKQEAKQLAAKLAYLQILSEETSVKSDYLSSGSFATTCESQSNSLVTSTLASESSSEGDFSADTSEINSNSDSLNSSSLLMNGLRNNQRKAKRSLAPRFDLPDMKETKYTVDKRFGMDFKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVKYNNEKAEREVKALAKLDHVNIVHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLFIQMEFCDKGTLEQWIEKRRGEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNIFLVDTKQVKIGDFGLVTSLKNDGKRTRSKGTLRYMSPEQISSQDYGKEVDLYALGLILAELLHVCDTAFETSKFFTDLRDGIISDIFDKKEKTLLQKLLSKKPEDRPNTSEILRTLTVWKKSPEKNERHTC
Atome Classification :
(35 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300------....---.-----..310.......320.......330.......340.......350.......360.......370.......380.-.--.-.--....390.......400.......-410.......420.......430......---.440.-.....-.450.......460.-.......470.......480....--...490.......500...---.---..---...---510--.........520.......530.......540.......550
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MAGDL
S
A
G
F
F
M
E
E
L
N
T
Y
R
Q
KQ
G
V
V
L
K
Y
Q
ELPNSGPPHD
R
R
F
T
F
Q
V
I
IDGREFPEGEGR
S
K
K
E
A
K
N
A
A
A
K
L
A
V
E
I
L
NKEKKAVS
P
L
L
L
T
TTNSSEGLSM
G
N
Y
I
G
L
I
N
R
I
A
QKK
R
L
T
V
N
Y
E
Q
C
ASGVHGPEG
F
H
Y
K
CKMG
Q
K
E
YSIGTGS
T
K
Q
E
A
K
Q
L
A
A
K
L
A
Y
L
Q
I
LSEETSVKSDYLSSGS
F
A
T
T
CESQSN
S
L
V
T
S
TLASESSSEGDFSADTSEINSNSDSL
N
S
S
S
L
L
M
N
G
L
RN
N
Q
R
K
A
K
R
SLAPRFDLPDMKET
K
Y
T
V
D
K
RFGM
D
F
K
E
I
E
L
I
GSGGF
G
Q
V
F
K
A
K
HRIDG
K
T
Y
V
I
K
R
V
KYN
N
------
E
K
A
E
---
R
-----
E
V
K
A
L
A
KLD
H
V
N
I
V
H
YNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSK
T
K
C
L
F
I
Q
M
EFCDK
G
T
L
E
Q
W
I
E
K
R-R-G--
E
-
K
--
L
D
K
V
L
A
L
E
L
F
E
Q
I
T
K
G
V
D
Y
I
H
S
K
K
-
L
I
H
RDLKPS
N
I
F
L
V
DT
K
Q
V
K
IGD
F
G
L
V
T
S
---
L
KNDG-KRTRS-KG
T
L
R
YM
S
P
E
QI-SS-QDYGKE
V
D
L
Y
A
L
G
L
I
L
A
E
L
L
H
V
C
D
--
T
A
F
E
T
S
K
F
F
T
D
L
R
D
--
G
I
I
---
S
---
D
I
---
F
D
K
---
K
----
E
K
T
L
L
Q
K
L
L
SKKPEDRP
N
T
S
E
I
L
R
T
L
T
V
W
KKSPEKNERHTC
51
HHSearch
79.36
99%
-91
- C2 -
2A19
1
E2AK2_HUMAN
B:
[3-274]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
T
V
D
K
R
F
G
M
D
F
K
E
I
E
L
I
G
S
G
G
F
G
Q
V
F
K
A
K
H
R
I
D
G
K
T
Y
V
I
K
R
V
K
Y
N
N
------
E
K
A
E
---
R
-----
E
V
K
A
L
A
K
L
D
H
V
N
I
V
H
Y
N
G
C
W
D
G
F
D
Y
D
----------------------
R
S
K
T
K
C
L
F
I
Q
M
E
F
C
D
K
G
T
L
E
Q
W
I
E
K
R
-
R
-
G
--
E
-
K
--
L
D
K
V
L
A
L
E
L
F
E
Q
I
T
K
G
V
D
Y
I
H
S
K
K
-
L
I
N
R
D
L
K
P
S
N
I
F
L
V
D
T
K
Q
V
K
I
G
D
F
G
L
V
T
S
---
L
K
N
D
G
-
K
R
T
R
S
-
K
G
T
L
R
Y
M
S
P
E
Q
I
-
S
S
-
Q
D
Y
G
K
E
V
D
L
Y
A
L
G
L
I
L
A
E
L
L
H
V
C
D
--
T
A
F
E
T
S
K
F
F
T
D
L
R
D
--
G
I
I
---
S
---
D
I
---
F
D
K
---
K
----
E
K
T
L
L
Q
K
L
L
S
K
K
P
E
D
R
P
N
T
S
E
I
L
R
T
L
T
V
W
K
K
----------
2
PsiBlast_PDB
78.34
94%
-91
- C2 -
2A19
1
E2AK2_HUMAN
B:
[3-274]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
T
V
D
K
R
F
G
M
D
F
K
E
I
E
L
I
G
S
G
G
F
G
Q
V
F
K
A
K
H
R
I
D
G
K
T
Y
V
I
K
R
V
K
Y
N
N
------
E
K
A
E
---
R
-----
E
V
K
A
L
A
K
L
D
H
V
N
I
V
H
Y
N
G
C
W
D
G
F
D
Y
D
----------------------
R
S
K
T
K
C
L
F
I
Q
M
E
F
C
D
K
G
T
L
E
Q
W
I
E
K
R
-
R
-
G
--
E
-
K
--
L
D
K
V
L
A
L
E
L
F
E
Q
I
T
K
G
V
D
Y
I
H
S
K
K
-
L
I
N
R
D
L
K
P
S
N
I
F
L
V
D
T
K
Q
V
K
I
G
D
F
G
L
V
T
S
---
L
K
N
D
G
-
K
R
T
R
S
-
K
G
T
L
R
Y
M
S
P
E
Q
I
-
S
S
-
Q
D
Y
G
K
E
V
D
L
Y
A
L
G
L
I
L
A
E
L
L
H
V
C
D
--
T
A
F
E
T
S
K
F
F
T
D
L
R
D
--
G
I
I
---
S
---
D
I
---
F
D
K
---
K
----
E
K
T
L
L
Q
K
L
L
S
K
K
P
E
D
R
P
N
T
S
E
I
L
R
T
L
T
V
W
K
K
----------
21
PsiBlast_CBE
73.71
94%
-99
- C2 -
2A19
1
E2AK2_HUMAN
C:
[3-274]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
T
V
D
K
R
F
G
M
D
F
K
E
I
E
L
I
G
S
G
G
F
G
Q
V
F
K
A
K
H
R
I
D
G
K
T
Y
V
I
K
R
V
K
Y
N
N
------
E
K
A
E
---
R
-----
E
V
K
A
L
A
K
L
D
H
V
N
I
V
H
Y
N
G
C
W
D
G
F
D
Y
D
P
E
T
S
--------------------
K
T
K
C
L
F
I
Q
M
E
F
C
D
K
G
T
L
----------------------
L
A
L
E
L
F
E
Q
I
T
K
G
V
D
Y
I
H
S
K
K
-
L
I
N
R
D
L
K
P
S
N
I
F
L
V
D
T
K
Q
V
K
I
G
D
F
G
L
V
------------------------------------
G
K
E
V
D
L
Y
A
L
G
L
I
L
A
E
L
L
----------------------
G
I
I
---
S
---
D
I
---
F
D
K
---
K
----
E
K
T
L
L
Q
K
L
L
S
K
K
P
E
D
R
P
N
T
S
E
I
L
R
T
L
T
V
W
K
K
----------
8
PsiBlast_PDB
66.98
38%
-91
- C2 -
4X7N
2
A:
[13-295]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
I
--
S
R
Y
L
T
D
F
E
P
I
Q
C
L
G
R
G
G
F
G
V
V
F
E
A
K
N
K
V
D
D
C
N
Y
A
I
K
R
I
R
L
P
N
R
E
L
A
R
-
E
K
V
M
---
R
-----
E
V
K
A
L
A
K
L
E
H
P
G
I
V
R
Y
F
N
A
W
--
L
E
A
P
-------------------------
K
V
Y
L
Y
I
Q
M
Q
L
C
R
K
E
N
L
K
D
W
M
N
G
R
C
T
-
I
--
E
-
E
--
R
E
R
S
V
C
L
H
I
F
L
Q
I
A
E
A
V
E
F
L
H
S
K
G
-
L
M
H
R
N
L
K
P
S
N
I
F
F
T
M
D
D
V
V
K
V
G
D
F
G
L
V
T
------------------
T
K
L
Y
M
S
P
E
Q
I
-
H
G
-
N
S
Y
S
H
K
V
D
I
F
S
L
G
L
I
L
F
E
L
L
Y
P
F
S
--
T
Q
M
E
R
V
R
T
L
T
D
V
R
N
--
L
K
F
---
P
---
P
L
---
F
T
Q
---
K
Y
P
C
-
E
Y
V
M
V
Q
D
M
L
S
P
S
P
M
E
R
P
E
A
I
N
I
I
E
N
A
V
F
E
D
L
D
F
P
G
K
T
V
---
6
PsiBlast_PDB
66.42
38%
-91
- C2 -
4X7K
3
A:
[13-295]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
I
--
S
R
Y
L
T
D
F
E
P
I
Q
C
L
G
R
G
G
F
G
V
V
F
E
A
K
N
K
V
D
D
C
N
Y
A
I
K
R
I
R
L
P
N
R
E
L
A
R
-
E
K
V
M
---
R
-----
E
V
K
A
L
A
K
L
E
H
P
G
I
V
R
Y
F
N
A
W
--
L
E
A
P
P
------------------------
K
V
Y
L
Y
I
Q
M
Q
L
C
R
K
E
N
L
K
D
W
M
N
G
R
C
T
-
I
--
E
-
E
--
R
E
R
S
V
C
L
H
I
F
L
Q
I
A
E
A
V
E
F
L
H
S
K
G
-
L
M
H
R
N
L
K
P
S
N
I
F
F
T
M
D
D
V
V
K
V
G
D
F
G
L
V
T
------------------
T
K
L
Y
M
S
P
E
Q
I
-
H
G
-
N
S
Y
S
H
K
V
D
I
F
S
L
G
L
I
L
F
E
L
L
Y
P
F
S
--
T
Q
M
E
R
V
R
T
L
T
D
V
R
N
--
L
K
F
---
P
---
P
L
---
F
T
Q
---
K
Y
P
C
-
E
Y
V
M
V
Q
D
M
L
S
P
S
P
M
E
R
P
E
A
I
N
I
I
E
N
A
V
F
E
D
L
D
F
P
G
K
T
V
---
10
PsiBlast_PDB
66.11
38%
-94
- C2 -
4X7H
1
A:
[13-295]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
I
--
S
R
Y
L
T
D
F
E
P
I
Q
C
L
G
R
G
G
F
G
V
V
F
E
A
K
N
K
V
D
D
C
N
Y
A
I
K
R
I
R
L
P
N
R
E
L
A
R
-
E
K
V
M
---
R
-----
E
V
K
A
L
A
K
L
E
H
P
G
I
V
R
Y
F
N
A
W
--
L
E
A
P
P
------------------------
K
V
Y
L
Y
I
Q
M
Q
L
C
R
K
E
N
L
K
D
W
M
N
G
R
C
T
-
I
--
E
-
E
--
R
E
R
S
V
C
L
H
I
F
L
Q
I
A
E
A
V
E
F
L
H
S
K
G
-
L
M
H
R
N
L
K
P
S
N
I
F
F
T
M
D
D
V
V
K
V
G
D
F
---------------------
G
T
K
L
Y
M
S
P
E
Q
I
-
H
G
-
N
S
Y
S
H
K
V
D
I
F
S
L
G
L
I
L
F
E
L
L
Y
P
F
S
--
T
Q
M
E
R
V
R
T
L
T
D
V
R
N
--
L
K
F
---
P
---
P
L
---
F
T
Q
---
K
Y
P
C
-
E
Y
V
M
V
Q
D
M
L
S
P
S
P
M
E
R
P
E
A
I
N
I
I
E
N
A
V
F
E
D
L
D
F
P
G
K
T
----
13
PsiBlast_PDB
66.09
38%
-97
- C2 -
4M7I
1
A:
[2-278]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
Y
L
T
D
F
E
P
I
Q
C
L
G
R
--
F
G
V
V
F
E
A
K
N
K
V
D
D
C
N
Y
A
I
K
R
I
R
L
P
N
R
E
L
A
R
-
E
K
V
M
---
R
-----
E
V
K
A
L
A
K
L
E
H
P
G
I
V
R
Y
F
N
A
W
-------------
L
E
K
---------------
K
V
Y
L
Y
I
Q
M
Q
L
C
R
K
E
N
L
K
D
W
M
N
G
R
-
C
-
T
I-
E
-
E
--
R
E
R
S
V
C
L
H
I
F
L
Q
I
A
E
A
V
E
F
L
H
S
K
G
-
L
M
H
R
D
L
K
P
S
N
I
F
F
T
M
D
D
V
V
K
V
G
D
F
G
L
V
------------------
G
T
K
L
Y
M
S
P
E
Q
I
-
H
G
-
N
S
Y
S
H
K
V
D
I
F
S
L
G
L
I
L
F
E
L
L
Y
P
F
S
--
T
Q
M
E
R
V
R
T
L
T
D
V
R
N
--
L
K
F
---
P
---
P
L
---
F
T
Q
---
K
Y
P
C
-
E
Y
V
M
V
Q
D
M
L
S
P
S
P
M
E
R
P
E
A
I
N
I
I
E
N
A
V
F
E
D
L
----------
7
PsiBlast_PDB
65.98
38%
-89
- C2 -
4X7L
3
A:
[13-295]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
I
--
S
R
Y
L
T
D
F
E
P
I
Q
C
L
G
R
G
G
F
G
V
V
F
E
A
K
N
K
V
D
D
C
N
Y
A
I
K
R
I
R
L
P
N
R
E
L
A
R
-
E
K
V
M
---
R
-----
E
V
K
A
L
A
K
L
E
H
P
G
I
V
R
Y
F
N
A
W
--
L
E
A
P
P
------------------------
K
V
Y
L
Y
I
Q
M
Q
L
C
R
K
E
N
L
K
D
W
M
N
G
R
C
T
-
I
--
E
-
E
--
R
E
R
S
V
C
L
H
I
F
L
Q
I
A
E
A
V
E
F
L
H
S
K
G
-
L
M
H
R
N
L
K
P
S
N
I
F
F
T
M
D
D
V
V
K
V
G
D
F
G
L
V
T
------------------
T
K
L
Y
M
S
P
E
Q
I
-
H
G
-
N
S
Y
S
H
K
V
D
I
F
S
L
G
L
I
L
F
E
L
L
Y
P
F
S
--
T
Q
M
E
R
V
R
T
L
T
D
V
R
N
--
L
K
F
---
P
---
P
L
---
F
T
Q
---
K
Y
P
C
-
E
Y
V
M
V
Q
D
M
L
S
P
S
P
M
E
R
P
E
A
I
N
I
I
E
N
A
V
F
E
D
L
D
F
P
G
K
T
V
---
5
PsiBlast_PDB
65.97
38%
-96
- C2 -
4X7J
2
A:
[13-295]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
I
--
S
R
Y
L
T
D
F
E
P
I
Q
C
L
G
R
G
G
F
G
V
V
F
E
A
K
N
K
V
D
D
C
N
Y
A
I
K
R
I
R
L
P
N
R
E
L
A
R
-
E
K
V
M
---
R
-----
E
V
K
A
L
A
K
L
E
H
P
G
I
V
R
Y
F
N
A
W
--
L
E
A
P
P
------------------------
K
V
Y
L
Y
I
Q
M
Q
L
C
R
K
E
N
L
K
D
W
M
N
G
R
C
T
-
I
--
E
-
E
--
R
E
R
S
V
C
L
H
I
F
L
Q
I
A
E
A
V
E
F
L
H
S
K
G
-
L
M
H
R
N
L
K
P
S
N
I
F
F
T
M
D
D
V
V
K
V
G
D
F
G
L
V
--------------------
K
L
Y
M
S
P
E
Q
I
-
H
G
-
N
S
Y
S
H
K
V
D
I
F
S
L
G
L
I
L
F
E
L
L
Y
P
F
S
--
T
Q
M
E
R
V
R
T
L
T
D
V
R
N
--
L
K
F
---
P
---
P
L
---
F
T
Q
---
K
Y
P
C
-
E
Y
V
M
V
Q
D
M
L
S
P
S
P
M
E
R
P
E
A
I
N
I
I
E
N
A
V
F
E
D
L
D
F
P
G
K
T
----
53
HHSearch
65.35
43%
-88
- C2 -
4G31
2
A:
[1-280]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
R
Y
L
T
D
F
E
P
I
Q
C
L
G
R
G
--
G
V
V
F
E
A
K
N
K
V
D
D
C
N
Y
A
I
K
R
I
R
L
P
N
R
E
L
A
R
-
E
K
V
M
---
R
-----
E
V
K
A
L
A
K
L
E
H
P
G
I
V
R
Y
F
N
A
W
L
E
K
N
---------------------------
K
V
Y
L
Y
I
Q
M
Q
L
C
R
K
E
N
L
K
D
W
M
N
G
R
-
C
-
T
--
I
E
E
--
R
E
R
S
V
C
L
H
I
F
L
Q
I
A
E
A
V
E
F
L
H
S
K
G
-
L
M
H
R
D
L
K
P
S
N
I
F
F
T
M
D
D
V
V
K
V
G
D
F
G
L
V
------------------
G
T
K
L
Y
M
S
P
E
Q
I
-
H
G
-
N
S
Y
S
H
K
V
D
I
F
S
L
G
L
I
L
F
E
L
L
Y
P
F
S
--
T
Q
M
E
R
V
R
T
L
T
D
V
R
N
--
L
K
F
---
P
---
P
L
---
F
T
Q
K
Y
P
C
----
E
Y
V
M
V
Q
D
M
L
S
P
S
P
M
E
R
P
E
A
I
N
I
I
E
N
A
V
F
E
D
L
----------
12
PsiBlast_PDB
65.03
38%
-96
- C2 -
4G31
2
A:
[2-278]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
Y
L
T
D
F
E
P
I
Q
C
L
G
R
G
--
G
V
V
F
E
A
K
N
K
V
D
D
C
N
Y
A
I
K
R
I
R
L
P
N
R
E
L
A
R
-
E
K
V
M
---
R
-----
E
V
K
A
L
A
K
L
E
H
P
G
I
V
R
Y
F
N
A
W
-------------
L
E
K
N
--------------
K
V
Y
L
Y
I
Q
M
Q
L
C
R
K
E
N
L
K
D
W
M
N
G
R
-
C
-
T
I-
E
-
E
--
R
E
R
S
V
C
L
H
I
F
L
Q
I
A
E
A
V
E
F
L
H
S
K
G
-
L
M
H
R
D
L
K
P
S
N
I
F
F
T
M
D
D
V
V
K
V
G
D
F
G
L
V
------------------
G
T
K
L
Y
M
S
P
E
Q
I
-
H
G
-
N
S
Y
S
H
K
V
D
I
F
S
L
G
L
I
L
F
E
L
L
Y
P
F
S
--
T
Q
M
E
R
V
R
T
L
T
D
V
R
N
--
L
K
F
---
P
---
P
L
---
F
T
Q
---
K
Y
P
C
-
E
Y
V
M
V
Q
D
M
L
S
P
S
P
M
E
R
P
E
A
I
N
I
I
E
N
A
V
F
E
D
L
----------
9
PsiBlast_PDB
64.78
38%
-93
- C2 -
4X7O
1
A:
[13-295]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
I
--
S
R
Y
L
T
D
F
E
P
I
Q
C
L
G
R
G
--
G
V
V
F
E
A
K
N
K
V
D
D
C
N
Y
A
I
K
R
I
R
L
P
N
R
E
L
A
R
-
E
K
V
M
---
R
-----
E
V
K
A
L
A
K
L
E
H
P
G
I
V
R
Y
F
N
A
W
--
L
E
A
P
P
------------------------
K
V
Y
L
Y
I
Q
M
Q
L
C
R
K
E
N
L
K
D
W
M
N
G
R
C
T
-
I
--
E
-
E
--
R
E
R
S
V
C
L
H
I
F
L
Q
I
A
E
A
V
E
F
L
H
S
K
G
-
L
M
H
R
N
L
K
P
S
N
I
F
F
T
M
D
D
V
V
K
V
G
D
F
---------------------
G
T
K
L
Y
M
S
P
E
Q
I
-
H
----
Y
S
H
K
V
D
I
F
S
L
G
L
I
L
F
E
L
L
Y
P
F
S
--
T
Q
M
E
R
V
R
T
L
T
D
V
R
N
--
L
K
F
---
P
---
P
L
---
F
T
Q
---
K
Y
P
C
-
E
Y
V
M
V
Q
D
M
L
S
P
S
P
M
E
R
P
E
A
I
N
I
I
E
N
A
V
F
E
D
L
D
---------
22
PsiBlast_CBE
61.86
33%
-93
- C2 -
1ZY4
1
B:
[3-284]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
Y
A
S
D
F
E
E
I
A
V
L
G
Q
G
A
F
G
Q
V
V
K
A
R
N
A
L
D
S
R
Y
Y
A
I
K
K
I
R
H
T
E
------
E
K
L
S
T
I
L
S
-----
E
V
M
L
L
A
S
L
N
H
Q
Y
V
V
R
Y
Y
A
A
W
-------------
L
E
R
R
N
F
---
V
K
-------
K
S
T
L
F
I
Q
M
E
Y
C
E
N
G
T
L
Y
D
L
I
H
S
E
-
N
L
N
--
Q
-
Q
--
R
D
E
Y
W
--
R
L
F
R
Q
I
L
E
A
L
S
Y
I
H
S
Q
G
-
I
I
H
R
D
L
K
P
M
N
I
F
I
D
E
S
R
N
V
K
I
G
D
F
G
L
------------------
I
G
T
A
M
Y
V
A
T
E
V
L
------
Y
N
E
K
I
D
M
Y
S
L
G
I
I
F
F
E
M
I
Y
P
F
S
--
T
G
M
E
R
V
N
I
L
K
K
L
R
S
--
V
S
I
EFP
P
---
D
F
---
D
D
N
---
K
M
K
V
-
E
K
K
I
I
R
L
L
I
D
H
D
P
N
K
R
P
G
A
R
T
L
L
N
S
G
W
L
P
V
-----------
56
HHSearch
61.12
33%
-90
- C2 -
2W5A
5
NEK2_HUMAN
A:
[4-269]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
A
E
D
Y
E
V
L
Y
T
I
G
T
G
S
Y
G
R
C
Q
K
I
R
R
K
S
D
G
K
I
L
V
W
K
E
L
D
Y
G
S
MT
E
A
E
K
Q
M
L
V
---
S
-----
E
V
N
L
L
R
E
L
K
H
P
N
I
V
R
Y
Y
D
R
I
I
D
R
T
---------------------------
N
T
T
L
Y
I
V
M
E
Y
C
E
G
G
D
L
A
S
V
I
T
K
G
-
T
-
K
E
R
Q
-
Y
--
L
D
E
E
F
V
L
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
R
R
S
--
L
H
R
D
L
K
P
A
N
V
F
L
D
G
K
Q
N
V
K
L
G
D
F
G
L
A
R
I
---
L
---
T
S
F
A
K
T
F
-
V
G
T
P
Y
Y
M
S
P
E
Q
M
-
N
R
-
M
-
Y
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
L
M
P
PF
T
A
F
S
Q
K
E
L
A
G
K
I
R
E
--
G
K
F
---
R
RIP
Y
R
---
Y
S
D
---
E
----
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
R
P
S
V
E
E
I
L
E
N
P
L
I
L
E
H
H
H
H
H
H
-----
14
PsiBlast_PDB
61.04
33%
-87
- C2 -
1ZY4
1
GCN2_YEAST
A:
[3-284]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
Y
A
S
D
F
E
E
I
A
V
L
G
Q
G
A
F
G
Q
V
V
K
A
R
N
A
L
D
S
R
Y
Y
A
I
K
K
I
R
H
T
E
------
E
K
L
S
T
I
L
S
-----
E
V
M
L
L
A
S
L
N
H
Q
Y
V
V
R
Y
Y
A
A
W
-------------
L
E
R
R
N
F
---
V
K
------
K
K
S
T
L
F
I
Q
M
E
Y
C
E
N
G
T
L
Y
D
L
I
H
S
E
-
N
L
N
--
Q
-
Q
--
R
D
E
Y
W
--
R
L
F
R
Q
I
L
E
A
L
S
Y
I
H
S
Q
G
-
I
I
H
R
D
L
K
P
M
N
I
F
I
D
E
S
R
N
V
K
I
G
D
F
G
L
A
K
N
VHR---------------
A
M
Y
V
A
T
E
V
L
D
G
T
-
G
H
Y
N
E
K
I
D
M
Y
S
L
G
I
I
F
F
E
M
I
Y
P
F
S
--
T
G
M
E
R
V
N
I
L
K
K
L
R
S
--
V
S
I
EFP
P
---
D
F
---
D
D
N
---
K
M
K
V
-
E
K
K
I
I
R
L
L
I
D
H
D
P
N
K
R
P
G
A
R
T
L
L
N
S
G
W
L
P
V
K
H
Q
D
E
V
I
K
E
A
L
31
PsiBlast_CBE
60.52
31%
-87
- C2 -
2XKD
1
NEK2_HUMAN
A:
[7-266]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Y
E
V
L
Y
T
I
G
T
G
---
R
C
Q
K
I
R
R
K
S
D
G
K
I
L
V
W
K
E
L
D
Y
G
S
M-----
T
E
A
E
---
K
Q
M
L
V
S
E
V
N
L
L
R
E
L
K
H
P
N
I
V
R
Y
----------------------
Y
D
----
R
I
I
D
R
T
N
T
T
-
L
Y
I
V
M
E
Y
C
E
G
G
D
L
A
S
V
I
T
K
G
-
T
-
K
--
E
-
R
QY
L
D
E
E
F
V
L
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
R
R
S
D-----
L
K
P
A
N
V
F
L
D
G
K
Q
N
V
K
L
G
D
F
------------------
T
F
V
G
T
P
Y
Y
M
S
P
E
Q
M
-
N
R
-
M
S
Y
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
L
M
P
PF
T
A
F
S
Q
K
E
L
A
G
K
I
R
E
--
G
K
F
---
R
---
R
I
PYR
Y
S
D
---
E
----
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
R
P
S
V
E
E
I
L
E
N
P
L
I
L
E
H
H
H
H
H
H
-----
26
PsiBlast_CBE
60.49
31%
-80
- C2 -
2XNO
13
NEK2_HUMAN
A:
[7-266]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Y
E
V
L
Y
T
I
G
T
G
S
Y
G
R
C
Q
K
I
R
R
K
S
D
G
K
I
L
V
W
K
E
L
D
Y
G
S
M-----
T
E
A
E
---
K
Q
M
L
V
S
E
V
N
L
L
R
E
L
K
H
P
N
I
V
R
Y
----------------------
Y
D
----
R
I
I
D
R
T
N
T
T
-
L
Y
I
V
M
E
Y
C
E
G
G
D
L
A
S
V
I
T
K
G
-
T
-
K
--
E
-
R
Q
Y
L
D
E
E
F
V
L
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
R
R
S
----
R
D
L
K
P
A
N
V
F
L
D
G
K
Q
N
V
K
L
G
D
F
-------------------F
V
G
T
P
Y
Y
M
S
P
E
Q
M
-
N
R
----
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
L
M
P
PF
T
A
F
S
Q
K
E
L
A
G
K
I
R
E
--
G
K
F
---
R
---
R
I
PYR
Y
S
D
---
E
----
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
R
P
S
V
E
E
I
L
E
N
P
L
I
L
E
H
H
H
H
H
H
-----
30
PsiBlast_CBE
60.40
31%
-89
- C2 -
2XKE
1
NEK2_HUMAN
A:
[7-266]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Y
E
V
L
Y
T
I
G
T
G
---
R
C
Q
K
I
R
R
K
S
D
G
K
I
L
V
W
K
E
L
D
Y
G
S
M-----
T
E
A
E
---
K
Q
M
L
V
S
E
V
N
L
L
R
E
L
K
H
P
N
I
V
R
Y
----------------------
Y
D
----
R
I
I
D
R
T
N
T
T
-
L
Y
I
V
M
E
Y
C
E
G
G
D
L
A
S
V
I
T
K
G
-
T
-
K
--
E
-
R
QY
L
D
E
E
F
V
L
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
R
R
S
D-----
L
K
P
A
N
V
F
L
D
G
K
Q
N
V
K
L
G
D
F
----------------------
T
P
Y
Y
M
S
P
E
Q
M
-
N
-----
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
L
M
P
PF
T
A
F
S
Q
K
E
L
A
G
K
I
R
E
--
G
K
F
---
R
---
R
I
PYR
Y
S
D
---
E
----
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
R
P
S
V
E
E
I
L
E
N
P
L
I
L
E
H
H
H
H
H
H
-----
33
PsiBlast_CBE
60.34
31%
-85
- C2 -
2XK8
1
NEK2_HUMAN
A:
[7-266]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Y
E
V
L
Y
T
I
G
T
----
R
C
Q
K
I
R
R
K
S
D
G
K
I
L
V
W
K
E
L
D
Y
G
S
M-----
T
E
A
E
---
K
Q
M
L
V
S
E
V
N
L
L
R
E
L
K
H
P
N
I
V
R
Y
----------------------
Y
D
----
R
I
I
D
R
T
N
T
T
-
L
Y
I
V
M
E
Y
C
E
G
G
D
L
A
S
V
I
T
K
G
-
T
-
K
--
E
-
R
QY
L
D
E
E
F
V
L
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
R
R
S
----
R
D
L
K
P
A
N
V
F
L
D
G
K
Q
N
V
K
L
G
D
F
-------------------F
V
G
T
P
Y
Y
M
S
P
E
Q
M
-
N
-----
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
L
M
P
PF
T
A
F
S
Q
K
E
L
A
G
K
I
R
E
--
G
K
F
---
R
---
R
I
PYR
Y
S
D
---
E
----
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
R
P
S
V
E
E
I
L
E
N
P
L
I
L
E
H
H
H
H
H
H
-----
15
PsiBlast_PDB
60.29
33%
-87
- C2 -
1ZY5
1
GCN2_YEAST
A:
[3-284]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
Y
A
S
D
F
E
E
I
A
V
L
G
Q
G
A
F
G
Q
V
V
K
A
R
N
A
L
D
S
R
Y
Y
A
I
K
K
I
R
H
T
E
------
E
K
L
S
T
I
L
S
-----
E
V
M
L
L
A
S
L
N
H
Q
Y
V
V
R
Y
Y
A
A
W
-------------
L
E
R
R
N
F
---
V
K
------
K
K
S
T
L
F
I
Q
M
E
Y
C
E
N
G
T
L
Y
D
L
I
H
S
E
-
N
L
N
--
Q
-
Q
--
R
D
E
Y
W
--
R
L
F
R
Q
I
L
E
A
L
S
Y
I
H
S
Q
G
-
I
I
H
R
D
L
K
P
M
N
I
F
I
D
E
S
R
N
V
K
I
G
D
F
G
L
A
K
N
VHR---------------
A
M
Y
V
A
T
E
V
L
D
G
T
-
G
H
Y
N
E
K
I
D
M
Y
S
L
G
I
I
F
F
E
M
I
Y
P
F
S
--
T
G
M
E
R
V
N
I
L
K
K
L
R
S
--
V
S
I
EFP
P
---
D
F
---
D
D
N
---
K
M
K
V
-
E
K
K
I
I
R
L
L
I
D
H
D
P
N
K
R
P
G
A
R
T
L
L
N
S
G
W
L
P
V
K
H
Q
D
E
V
I
K
E
A
L
24
PsiBlast_CBE
60.12
31%
-73
- C2 -
2W5B
1
NEK2_HUMAN
A:
[7-266]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Y
E
V
L
Y
T
I
G
T
G
S
Y
G
R
C
Q
K
I
R
R
K
S
D
G
K
I
L
V
W
K
E
L
D
Y
G
S
M-----
T
E
A
E
---
K
Q
M
L
V
S
E
V
N
L
L
R
E
L
K
H
P
N
I
V
R
Y
----------------------
Y
D
----
R
I
I
D
R
T
N
T
T
-
L
Y
I
V
M
E
Y
C
E
G
G
D
L
A
S
V
I
T
K
G
-
T
-
K
--
E
-
R
QY
L
D
E
E
F
V
L
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
R
R
S
--
L
H
R
D
L
K
P
A
N
V
F
L
D
G
K
Q
N
V
K
L
G
D
F
G
L
A
R
I
---
L
N
H
D
T
-
S
F
A
K
A
F
V
G
T
P
Y
Y
M
S
P
E
Q
M
-
N
R
-
M
S
Y
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
L
M
P
PF
T
A
F
S
Q
K
E
L
A
G
K
I
R
E
--
G
K
F
---
R
---
R
I
PYR
Y
S
D
---
E
----
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
R
P
S
V
E
E
I
L
E
N
P
L
I
L
E
H
H
H
H
H
H
-----
20
PsiBlast_PDB
60.08
31%
-89
- C2 -
2JAV
1
NEK2_HUMAN
A:
[7-266]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Y
E
V
L
Y
T
I
G
T
G
S
Y
G
R
C
Q
K
I
R
R
K
S
D
G
K
I
L
V
W
K
E
L
D
Y
G
S
M-----
T
E
A
E
---
K
Q
M
L
V
S
E
V
N
L
L
R
E
L
K
H
P
N
I
V
R
Y
----------------------
Y
D
----
R
I
I
D
----
T
-
L
Y
I
V
M
E
Y
C
E
G
G
D
L
A
S
V
I
T
K
G
-
T
-
K
--
E
-
R
QY
L
D
E
E
F
V
L
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
R
R
S
D-----
L
K
P
A
N
V
F
L
D
G
K
Q
N
V
K
L
G
D
F
G
L
A
R
I
---
L
------------
G
T
P
Y
Y
M
S
P
E
Q
M
-
N
R
-
M
S
Y
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
L
M
P
PF
T
A
F
S
Q
K
E
L
A
G
K
I
R
E
--
G
K
F
---
R
---
R
I
PYR
Y
S
D
---
E
----
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
R
P
S
V
E
E
I
L
E
N
P
L
I
L
E
H
H
H
H
H
H
-----
23
PsiBlast_CBE
60.03
32%
-90
- C2 -
1ZYD
1
B:
[3-284]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
Y
A
S
D
F
E
E
I
A
V
L
G
Q
G
A
F
G
Q
V
V
K
A
R
N
A
L
D
S
R
Y
Y
A
I
K
K
I
R
H
T
E
------
E
K
L
S
T
I
L
S
-----
E
V
M
L
L
A
S
L
N
H
Q
Y
V
V
R
Y
Y
A
A
W
-------------
L
E
R
R
N
F
------------
K
S
T
L
F
I
Q
M
E
Y
C
E
N
R
T
L
Y
D
L
I
H
S
E
-
N
L
N
--
Q
-
Q
--
R
D
E
Y
W
--
R
L
F
R
Q
I
L
E
A
L
S
Y
I
H
S
Q
G
-
I
I
H
R
D
L
K
P
M
N
I
F
I
D
E
S
R
N
V
K
I
G
D
F
G
L
A
-----------------
I
G
T
A
M
Y
V
A
T
E
V
L
D
G
T
-
G
H
Y
N
E
K
I
D
M
Y
S
L
G
I
I
F
F
E
M
I
Y
P
F
S
--
T
G
M
E
R
V
N
I
L
K
K
L
R
S
--
V
S
I
EFP
P
---
D
F
---
D
D
N
---
K
M
K
V
-
E
K
K
I
I
R
L
L
I
D
H
D
P
N
K
R
P
G
A
R
T
L
L
N
S
G
W
L
P
V
-----------
54
HHSearch
59.94
34%
-76
- C2 -
1ZY4
1
GCN2_YEAST
A:
[2-284]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
R
Y
A
S
D
F
E
E
I
A
V
L
G
Q
G
A
F
G
Q
V
V
K
A
R
N
A
L
D
S
R
Y
Y
A
I
K
K
I
R
H
T
E
E
K
L
---
S
T
I
L
---
S
-----
E
V
M
L
L
A
S
L
N
H
Q
Y
V
V
R
Y
Y
A
A
W
L
E
R
R
N
F
V
K
----------------------
K
K
S
T
L
F
I
Q
M
E
Y
C
E
N
G
T
L
Y
D
L
I
H
S
E
-
N
-
L
----
N
--
Q
Q
R
D
E
Y
W
R
L
F
R
Q
I
L
E
A
L
S
Y
I
H
S
Q
G
-
I
I
H
R
D
L
K
P
M
N
I
F
I
D
E
S
R
N
V
K
I
G
D
F
G
L
A
K
N
---
V
H
R
------------
A
M
Y
V
A
T
E
V
L
-
D
G
T
G
H
Y
N
E
K
I
D
M
Y
S
L
G
I
I
F
F
E
M
I
Y
P
F
S
--
T
G
M
E
R
V
N
I
L
K
K
L
R
S
VS
I
E
F
---
P
---
P
D
---
F
D
D
---
N
KM
K
V
E
K
K
I
I
R
L
L
I
D
H
D
P
N
K
R
P
G
A
R
T
L
L
N
S
G
W
L
P
V
K
H
Q
D
E
V
I
K
E
A
L
29
PsiBlast_CBE
59.62
31%
-83
- C2 -
2XKF
1
NEK2_HUMAN
A:
[7-266]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Y
E
V
L
Y
T
I
G
T
G
---
R
C
Q
K
I
R
R
K
S
D
G
K
I
L
V
W
K
E
L
D
Y
G
S
M-----
T
E
A
E
---
K
Q
M
L
V
S
E
V
N
L
L
R
E
L
K
H
P
N
I
V
R
Y
----------------------
Y
D
----
R
I
I
D
R
T
N
T
T
-
L
Y
I
V
M
E
Y
C
E
G
G
D
L
A
S
V
I
T
K
G
-
T
-
K
--
E
-
R
QY
L
D
E
E
F
V
L
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
R
R
S
----
R
D
L
K
P
A
N
V
F
L
D
G
K
Q
N
V
K
L
G
D
F
-------------------F
V
G
T
P
Y
Y
M
S
P
E
Q
M
-
N
R
--
S
Y
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
L
M
P
PF
T
A
F
S
Q
K
E
L
A
G
K
I
R
E
--
G
K
F
---
R
---
R
I
PYR
Y
S
D
---
E
----
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
R
P
S
V
E
E
I
L
E
N
P
L
I
L
E
H
H
H
H
H
H
-----
35
PsiBlast_CBE
59.42
31%
-84
- C2 -
2XK6
1
NEK2_HUMAN
A:
[7-266]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Y
E
V
L
Y
T
I
G
-----
R
C
Q
K
I
R
R
K
S
D
G
K
I
L
V
W
K
E
L
D
Y
G
S
M-----
T
E
A
E
---
K
Q
M
L
V
S
E
V
N
L
L
R
E
L
K
H
P
N
I
V
R
Y
----------------------
Y
D
----
R
I
I
D
R
T
N
T
T
-
L
Y
I
V
M
E
Y
C
E
G
G
D
L
A
S
V
I
T
K
G
-
T
-
K
--
E
-
R
QY
L
D
E
E
F
V
L
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
R
R
S
----
R
D
L
K
P
A
N
V
F
L
D
G
K
Q
N
V
K
L
G
D
---------------------
V
G
T
P
Y
Y
M
S
P
E
Q
M
-
N
R
----
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
L
M
P
PF
T
A
F
S
Q
K
E
L
A
G
K
I
R
E
--
G
K
F
---
R
---
R
I
PYR
Y
S
D
---
E
----
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
R
P
S
V
E
E
I
L
E
N
P
L
I
L
E
H
H
H
H
H
H
-----
17
PsiBlast_PDB
59.36
32%
-86
- C2 -
1ZYD
1
GCN2_YEAST
A:
[3-284]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
Y
A
S
D
F
E
E
I
A
V
L
G
Q
G
A
F
G
Q
V
V
K
A
R
N
A
L
D
S
R
Y
Y
A
I
K
K
I
R
H
T
E
------
E
K
L
S
T
I
L
S
-----
E
V
M
L
L
A
S
L
N
H
Q
Y
V
V
R
Y
Y
A
A
W
-------------
L
E
R
R
N
F
---
V
K
------
K
K
S
T
L
F
I
Q
M
E
Y
C
E
N
R
T
L
Y
D
L
I
H
S
E
-
N
L
N
--
Q
-
Q
--
R
D
E
Y
W
--
R
L
F
R
Q
I
L
E
A
L
S
Y
I
H
S
Q
G
-
I
I
H
R
D
L
K
P
M
N
I
F
I
D
E
S
R
N
V
K
I
G
D
F
G
L
A
K
----------------
I
G
T
A
M
Y
V
A
T
E
V
L
D
G
T
-
G
H
Y
N
E
K
I
D
M
Y
S
L
G
I
I
F
F
E
M
I
Y
P
F
S
--
T
G
M
E
R
V
N
I
L
K
K
L
R
S
--
V
S
I
EFP
P
---
D
F
---
D
D
N
---
K
M
K
V
-
E
K
K
I
I
R
L
L
I
D
H
D
P
N
K
R
P
G
A
R
T
L
L
N
S
G
W
L
P
V
K
H
Q
D
E
V
I
K
E
A
L
38
PsiBlast_CBE
58.77
31%
-82
- C2 -
2WQO
1
NEK2_HUMAN
A:
[7-266]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Y
E
V
L
Y
T
I
G
T
G
---
R
C
Q
K
I
R
R
K
S
D
G
K
I
L
V
W
K
E
L
D
Y
G
S
M-----
T
E
A
E
---
K
Q
M
L
V
S
E
V
N
L
L
R
E
L
K
H
P
N
I
V
R
Y
----------------------
Y
D
----
R
I
I
D
R
T
N
T
T
-
L
Y
I
V
M
E
Y
C
E
G
G
D
L
A
S
V
I
T
K
G
-
T
-
K
--
E
-
R
QY
L
D
E
E
F
V
L
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
R
R
-------
L
K
P
A
N
V
F
L
D
G
K
Q
N
V
K
L
G
D
----------------------
G
T
P
Y
Y
M
S
P
E
Q
M
-
N
R
----
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
L
M
P
PF
T
A
F
S
Q
K
E
L
A
G
K
I
R
E
--
G
K
F
---
R
---
R
I
PYR
Y
S
D
---
E
----
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
R
P
S
V
E
E
I
L
E
N
P
L
I
L
E
H
H
H
H
H
H
-----
37
PsiBlast_CBE
58.73
31%
-79
- C2 -
2XK3
1
NEK2_HUMAN
A:
[7-266]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Y
E
V
L
Y
T
I
G
T
----
R
C
Q
K
I
R
R
K
S
D
G
K
I
L
V
W
K
E
L
D
Y
G
S
M-----
T
E
A
E
---
K
Q
M
L
V
S
E
V
N
L
L
R
E
L
K
H
P
N
I
V
R
Y
----------------------
Y
D
----
R
I
I
D
R
T
N
T
T
-
L
Y
I
V
M
E
Y
C
E
G
G
D
L
A
S
V
I
T
K
G
-
T
-
K
--
E
-
R
Q
Y
L
D
E
E
F
V
L
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
R
R
S
----
R
D
L
K
P
A
N
V
F
L
D
G
K
Q
N
V
K
L
G
D
F
G
-------------------
V
G
T
P
Y
Y
M
S
P
E
Q
M
-
N
R
----
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
L
M
P
PF
T
A
F
S
Q
K
E
L
A
G
K
I
R
E
--
G
K
F
---
R
---
R
I
PYR
Y
S
D
---
E
----
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
R
P
S
V
E
E
I
L
E
N
P
L
I
L
E
H
H
H
H
H
H
-----
27
PsiBlast_CBE
58.60
31%
-77
- C2 -
2XNN
6
NEK2_HUMAN
A:
[7-266]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Y
E
V
L
Y
T
I
G
T
--
Y
G
R
C
Q
K
I
R
R
K
S
D
G
K
I
L
V
W
K
E
L
D
Y
G
S
M-----
T
E
A
E
---
K
Q
M
L
V
S
E
V
N
L
L
R
E
L
K
H
P
N
I
V
R
Y
----------------------
Y
D
----
R
I
I
D
R
T
N
T
T
-
L
Y
I
V
M
E
Y
C
E
G
G
D
L
A
S
V
I
T
K
G
-
T
-
K
--
E
-
R
Q
Y
L
D
E
E
F
V
L
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
R
R
S
----
R
D
L
K
P
A
N
V
F
L
D
G
K
Q
N
V
K
L
G
D
F
G
------------------F
V
G
T
P
Y
Y
M
S
P
E
Q
M
-
N
R
---
Y
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
L
M
P
PF
T
A
F
S
Q
K
E
L
A
G
K
I
R
E
--
G
K
F
---
R
---
R
I
PYR
Y
S
D
---
E
----
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
R
P
S
V
E
E
I
L
E
N
P
L
I
L
E
H
H
H
H
H
H
-----
25
PsiBlast_CBE
58.57
31%
-79
- C2 -
2XNP
6
NEK2_HUMAN
A:
[7-266]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Y
E
V
L
Y
T
I
G
T
G
-
Y
G
R
C
Q
K
I
R
R
K
S
D
G
K
I
L
V
W
K
E
L
D
Y
G
S
M-----
T
E
A
E
---
K
Q
M
L
V
S
E
V
N
L
L
R
E
L
K
H
P
N
I
V
R
Y
----------------------
Y
D
----
R
I
I
D
R
T
N
T
T
-
L
Y
I
V
M
E
Y
C
E
G
G
D
L
A
S
V
I
T
K
G
-
T
-
K
--
E
-
R
Q
Y
L
D
E
E
F
V
L
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
R
R
S
---
H
R
D
L
K
P
A
N
V
F
L
D
G
K
Q
N
V
K
L
G
D
F
G
L
-----------------F
V
G
T
P
Y
Y
M
S
P
E
Q
M
-
N
R
----
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
L
M
P
PF
T
A
F
S
Q
K
E
L
A
G
K
I
R
E
--
G
K
F
---
R
---
R
I
PYR
Y
S
D
---
E
----
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
R
P
S
V
E
E
I
L
E
N
P
L
I
L
E
H
H
H
H
H
H
-----
32
PsiBlast_CBE
58.54
31%
-77
- C2 -
2XKC
1
NEK2_HUMAN
A:
[7-266]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Y
E
V
L
Y
T
I
G
T
--
Y
G
R
C
Q
K
I
R
R
K
S
D
G
K
I
L
V
W
K
E
L
D
Y
G
S
M-----
T
E
A
E
---
K
Q
M
L
V
S
E
V
N
L
L
R
E
L
K
H
P
N
I
V
R
Y
----------------------
Y
D
----
R
I
I
D
R
T
N
T
T
-
L
Y
I
V
M
E
Y
C
E
G
G
D
L
A
S
V
I
T
K
G
-
T
-
K
--
E
-
R
QY
L
D
E
E
F
V
L
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
R
R
S
------
L
K
P
A
N
V
F
L
D
G
K
Q
N
V
K
L
G
D
----------------------
G
T
P
Y
Y
M
S
P
E
Q
M
-
N
R
----
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
L
M
P
PF
T
A
F
S
Q
K
E
L
A
G
K
I
R
E
--
G
K
F
---
R
---
R
I
PYR
Y
S
D
---
E
----
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
R
P
S
V
E
E
I
L
E
N
P
L
I
L
E
H
H
H
H
H
H
-----
34
PsiBlast_CBE
58.42
31%
-84
- C2 -
2XK7
1
NEK2_HUMAN
A:
[7-266]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Y
E
V
L
Y
T
I
G
T
G
---
R
C
Q
K
I
R
R
K
S
D
G
K
I
L
V
W
K
E
L
D
Y
G
S
M-----
T
E
A
E
---
K
Q
M
L
V
S
E
V
N
L
L
R
E
L
K
H
P
N
I
V
R
Y
----------------------
Y
D
----
R
I
I
D
R
T
N
T
T
-
L
Y
I
V
M
E
Y
C
E
G
G
D
L
A
S
V
I
T
K
G
-
T
-
K
--
E
-
R
Q
Y
L
D
E
E
F
V
L
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
R
R
S
----
R
D
L
K
P
A
N
V
F
L
D
G
K
Q
N
V
K
L
G
D
F
--------------------
V
G
T
P
Y
Y
M
S
P
E
Q
M
-
N
-----
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
L
M
P
PF
T
A
F
S
Q
K
E
L
A
G
K
I
R
E
--
G
K
F
---
R
---
R
I
PYR
Y
S
D
---
E
----
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
R
P
S
V
E
E
I
L
E
N
P
L
I
L
E
H
H
H
H
H
H
-----
36
PsiBlast_CBE
58.16
31%
-80
- C2 -
2XK4
1
NEK2_HUMAN
A:
[7-266]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Y
E
V
L
Y
T
I
G
T
--
Y
G
R
C
Q
K
I
R
R
K
S
D
G
K
I
L
V
W
K
E
L
D
Y
G
S
M-----
T
E
A
E
---
K
Q
M
L
V
S
E
V
N
L
L
R
E
L
K
H
P
N
I
V
R
Y
----------------------
Y
D
----
R
I
I
D
R
T
N
T
T
-
L
Y
I
V
M
E
Y
C
E
G
G
D
L
A
S
V
I
T
K
G
-
T
-
K
--
E
-
R
Q
Y
L
D
E
E
F
V
L
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
R
R
S
----
R
D
L
K
P
A
N
V
F
L
D
G
K
Q
N
V
K
L
G
D
F
G
L
-----------------F
V
G
T
P
Y
Y
M
S
P
E
Q
M
-
N
R
-
M
--
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
L
M
P
PF
T
A
F
S
Q
K
E
L
A
G
K
I
R
E
--
G
K
F
---
R
---
R
I
PYR
Y
S
D
---
E
----
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
R
P
S
V
E
E
I
L
E
N
P
L
I
L
E
H
H
H
H
H
H
-----
28
PsiBlast_CBE
57.68
31%
-82
- C2 -
2XNM
10
NEK2_HUMAN
A:
[7-266]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Y
E
V
L
Y
T
I
G
T
G
S
Y
G
R
C
Q
K
I
R
R
K
S
D
G
K
I
L
V
W
K
E
L
D
Y
G
S
M-----
T
E
A
E
---
K
Q
M
L
V
S
E
V
N
L
L
R
E
L
K
H
P
N
I
V
R
Y
----------------------
Y
D
----
R
I
I
D
R
T
N
T
T
-
L
Y
I
V
M
E
Y
C
E
G
G
D
L
A
S
V
I
T
K
G
-
T
-
K
--
E
-
R
Q
Y
L
D
E
E
F
V
L
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
R
R
-----
R
D
L
K
P
A
N
V
F
L
D
G
K
Q
N
V
K
L
G
D
F
G
L
A
R
I
---
L
----------F
V
G
T
P
Y
Y
M
S
P
E
Q
M
-
N
R
--
S
Y
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
L
M
P
PF
T
A
F
S
Q
K
E
L
A
G
K
I
R
E
--
G
K
F
---
R
---
R
I
PYR
Y
S
D
---
E
----
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
R
P
S
V
E
E
I
L
E
N
P
L
I
L
E
H
H
H
H
H
H
-----