@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : E2AK4_HUMAN: (2015-10-06 )
MAGGRGAPGRGRDEPPESYPQRQDHELQALEAIYGADFQDLRPDACGPVKEPPEINLVLYPQGLTGEEVYVKVDLRVKCPPTYPDVVPEIELKNAKGLSNESVNLLKSRLEELAKKHCGEVMIFELAYHVQSFLSEHNKPPPKSFHEEMLERRAQEEQQRLLEAKRKEEQEQREILHEIQRRKEEIKEEKKRKEMAKQERLEIASLSNQDHTSKKDPGGHRTAAILHGGSPDFVGNGKHRANSSGRSRRERQYSVCNSEDSPGSCEILYFNMGSPDQLMVHKGKCIGSDEQLGKLVYNALETATGGFVLLYEWVLQWQKKMGPFLTSQEKEKIDKCKKQIQGTETEFNSLVKLSHPNVVRYLAMNLKEQDDSIVVDILVEHISGVSLAAHLSHSGPIPVHQLRRYTAQLLSGLDYLHSNSVVHKVLSASNVLVDAEGTVKITDYSISKRLADICKEDVFEQTRVRFSDNALPYKTGKKGDVWRLGLLLLSLSQGQECGEYPVTIPSDLPADFQDFLKKCVCLDDKERWSPQQLLKHSFINPQPKMPLVEQSPEDSEGQDYVETVIPSNRLPSAAFFSETQRQFSRYFIEFEELQLLGKGAFGAVIKVQNKLDGCCYAVKRIPINPASRQFRRIKGEVTLLSRLHHENIVRYYNAWIERHERPAGPGTPPPDSGPLAKDDRAARGQPASDTDGLDSVEAAAPPPILSSSVEWSTSGERSASARFPATGPGSSDDEDDDEDEHGGVFSQSFLPASDSESDIIFDNEDENSKSQNQDEDCNEKNGCHESEPSVTTEAVHYLYIQMEYCEKSTLRDTIDQGLYRDTVRLWRLFREILDGLAYIHEKGMIHRDLKPVNIFLDSDDHVKIGDFGLATDHLAFSADSKQDDQTGDLIKSDPSGHLTGMVGTALYVSPEVQGSTKSAYNQKVDLFSLGIIFFEMSYHPMVTASERIFVLNQLRDPTSPKFPEDFDDGEHAKQKSVISWLLNHDPAKRPTATELLKSELLPPPQMEESELHEVLHHTLTNVDGKAYRTMMAQIFSQRISPAIDYTYDSDILKGNFSIRTAKMQQHVCETIIRIFKRHGAVQLCTPLLLPRNRQIYEHNEAALFMDHSGMLVMLPFDLRIPFARYVARNNILNLKRYCIERVFRPRKLDRFHPKELLECAFDIVTSTTNSFLPTAEIIYTIYEIIQEFPALQERNYSIYLNHTMLLKAILLHCGIPEDKLSQVYIILYDAVTEKLTRREVEAKFCNLSLSSNSLCRLYKFIEQKGDLQDLMPTINSLIKQKTGIAQLVKYGLKDLEEVVGLLKKLGIKLQVLINLGLVYKVQQHNGIIFQFVAFIKRRQRAVPEILAAGGRYDLLIPQFRGPQALGPVPTAIGVSIAIDKISAAVLNMEESVTISSCDLLVVSVGQMSMSRAINLTQKLWTAGITAEIMYDWSQSQEELQEYCRHHEITYVALVSDKEGSHVKVKSFEKERQTEKRVLETELVDHVLQKLRTKVTDERNGREASDNLAVQNLKGSFSNASGLFEIHGATVVPIVSVLAPEKLSASTRRRYETQVQTRLQTSLANLHQKSSEIEILAVDLPKETILQFLSLEWDADEQAFNTTVKQLLSRLPKQRYLKLVCDEIYNIKVEKKVSVLFLYSYRDDYYRILF
Atome Classification :
(17 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770.......780...--------....790.......800.......810------....--...820.......830.......840.......850.......860.......870.......880.......890.......900.......910........920.......930.....--------..940.......950.......960.......970..-----.....980.......990.......1000......1010......1020......1030......1040......1050......1060......1070......1080......1090......1100......1110......1120......1130......1140......1150......1160......1170......1180......1190......1200......1210......1220......1230......1240......1250......1260......1270......1280......1290......1300......1310......1320......1330......1340......1350......1360......1370......1380......1390......1400......1410......1420......1430......1440......1450......1460......1470......1480......1490......1500......1510......1520......1530......1540......1550......1560......1570......1580......1590......1600......1610......1620......1630......1640......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MAGGRGAPGRGRDEPPESYPQRQD
H
E
L
Q
A
L
E
A
I
YGA
D
F
Q
DLRPDACGPVKEPPE
I
N
L
V
L
YPQGLTG
E
E
V
Y
V
K
V
D
L
R
V
KCPPTYPDVVP
E
I
E
LKNAKGLSNE
S
V
N
L
L
K
S
R
L
E
E
L
A
K
K
HCG
E
V
M
I
F
E
L
A
Y
H
V
Q
S
F
L
S
EHNKPP
P
K
S
F
H
E
E
M
L
E
R
R
A
Q
E
E
Q
Q
R
L
L
E
A
K
R
K
E
E
Q
E
Q
R
E
I
L
H
E
I
Q
R
R
K
E
E
I
K
E
E
K
K
R
K
E
M
A
K
Q
E
R
L
E
I
A
SLSNQDHTSKKDPGGH
R
T
A
A
I
L
HGGSPDFVGNGKHRANSSGRS
R
R
E
R
Q
Y
SVCNSEDSPG
S
C
E
I
L
Y
F
NMGSPD
Q
L
M
V
HKGKCIG
S
D
E
Q
L
G
K
L
V
Y
N
A
L
E
TATG
G
F
V
L
L
Y
E
W
V
L
Q
W
Q
K
KMGPFLT
S
Q
E
K
E
K
I
D
K
C
K
K
Q
IQGT
E
T
E
F
N
S
L
V
KLSH
P
N
V
V
R
Y
L
A
M
NLKEQDDS
I
V
V
D
I
L
V
E
H
ISG
V
S
L
A
A
HLSHSGPI
P
V
H
Q
L
R
R
Y
T
A
Q
L
L
S
G
L
D
Y
LHS
N
S
V
V
H
K
V
LSAS
N
V
L
VDAEG
T
V
K
IT
D
Y
S
I
S
K
R
L
A
D
I
C
K
E
D
V
F
E
Q
T
R
VRFSDNALPYKTGKKG
D
V
W
R
L
G
L
L
L
L
S
L
SQGQECGEYPVTIPSDL
P
A
D
F
Q
D
F
L
K
K
C
VCLD
D
K
ERW
S
P
Q
Q
L
L
K
H
SFINPQPKMPLVEQSPEDSE
G
Q
D
Y
V
E
T
VIPSNRLP
S
A
A
F
F
S
E
T
Q
R
Q
F
S
R
Y
F
I
E
F
E
E
L
Q
L
LGKGA
F
G
A
V
I
K
VQNKL
D
G
C
C
Y
A
V
K
RIPIN
P
A
S
R
Q
F
R
R
I
K
G
E
V
T
L
L
S
R
L
H
H
E
N
I
V
R
Y
Y
N
A
W
I
E
RHERPAGPGTPPPDSGPLAKDDRAARGQPASDTDGLDSVEAAAPPPILSSS
V
E
WSTSGERSASARFPATGPGSSDDEDDDEDEHGGVFSQSFLPASDSES
D
I
I
FDNEDENSKSQNQDEDCNEKNGCHE--------SEPS
V
T
T
E
A
V
H
Y
L
Y
I
Q
M
EYCEK
S
T
L
R
D
------
T
I
D
Q
--
G
L
Y
R
D
T
V
R
L
W
R
L
F
R
E
I
L
D
G
L
A
Y
I
H
EKGMIHRDL
K
P
V
N
I
F
LDSDD
H
V
K
IGDFGLATD
H
L
A
FSADSKQDDQTGDLIKSDPSGHL
T
G
M
VG
T
A
L
Y
VSPE-VQGSTKSAYNQK
V
D
L
F
S
L
G
I
I
F
F
EMS--------YHPMVTAS
E
R
I
F
V
L
NQLRDPTSPKFPEDFDD
G
E
H
A
K
Q
-----
K
S
V
I
S
W
L
L
NHDPAKR
P
T
A
T
E
L
L
K
S
ELLPPPQM
E
E
S
E
L
H
E
V
L
H
H
T
LTNVD
G
K
A
Y
R
T
M
M
A
Q
I
F
S
Q
RISP
A
I
D
Y
TYDSDILKGN
F
S
I
R
T
A
K
M
Q
Q
H
V
C
E
T
I
I
R
I
F
K
RH
G
A
V
Q
L
C
T
P
LLLPRNR
Q
I
Y
EHN
E
A
A
L
F
MDHS
G
M
L
V
M
L
PFDLR
I
P
F
A
R
Y
V
A
RNNI
L
N
L
K
R
Y
C
I
E
R
V
FRPRKLDRF
H
P
K
E
L
L
E
C
A
F
D
I
V
TSTTNSFL
P
T
A
E
I
I
Y
T
I
Y
E
I
I
Q
EFP
A
L
Q
ER
N
Y
S
I
Y
L
N
H
T
M
L
L
K
A
I
L
L
HCGI
P
E
D
KL
S
Q
V
Y
I
I
L
Y
D
A
V
T
E
K
L
T
R
R
E
V
E
A
K
F
C
N
L
SLSS
N
S
L
C
R
L
Y
K
F
I
EQKG
D
L
Q
D
L
M
P
T
I
N
S
L
I
K
QKT
G
I
A
Q
L
V
K
Y
G
L
K
D
L
E
E
V
V
G
L
L
K
KLG
I
K
L
Q
V
L
I
NL
G
L
V
Y
K
V
QQHNG
I
I
F
Q
F
V
A
F
I
K
R
R
Q
R
A
V
P
E
I
L
AAGGRY
D
L
L
IPQFRGPQALGPVPTAI
G
V
S
I
A
I
D
K
I
S
A
A
V
LNMEES
V
T
ISSC
D
L
L
V
V
S
V
G
Q
M
S
M
S
R
A
I
N
L
T
Q
K
L
W
TAGI
T
A
E
I
M
YDWSQ
S
Q
E
E
L
Q
E
Y
C
R
HHE
I
T
Y
V
A
L
V
SDKEG
S
H
V
K
V
K
S
F
E
K
E
R
Q
T
E
K
R
V
L
E
T
E
L
V
D
H
V
L
Q
K
L
R
T
K
VTDERNGREASDNL
A
V
Q
N
LKGSFSNAS
G
L
F
E
IHG
A
T
V
V
P
I
V
S
V
LA
P
E
KL
S
A
S
T
R
R
R
Y
E
T
Q
V
Q
T
R
L
Q
T
S
L
A
N
L
H
QKSSE
I
E
I
L
A
VDL
P
K
E
T
I
L
Q
F
L
SLEWDA
D
E
Q
A
F
N
T
T
V
K
Q
L
L
S
RL
P
K
Q
R
Y
L
K
L
V
C
D
E
IYN
I
K
V
E
K
K
V
S
V
L
F
L
Y
SYRD
D
Y
Y
R
ILF
6
PsiBlast_PDB
49.18
36%
-27
- C2 -
4X7J
2
A:
[106-300]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
L
Y
I
Q
M
Q
L
C
R
K
E
N
L
K
D
W
M
N
G
R
C
T
I
E
E
-----
R
E
R
S
V
C
L
H
I
F
L
Q
I
A
E
A
V
E
F
L
H
S
K
G
L
M
H
R
N
L
K
P
S
N
I
F
F
T
M
D
D
V
V
K
V
G
D
F
G
L
V
----------------------------------
K
L
Y
M
S
P
E
Q
I
H
G
N
S
---
Y
S
H
K
V
D
I
F
S
L
G
L
I
L
F
E
L
L
--------
Y
-
P
F
S
T
Q
M
E
R
V
R
T
L
T
D
V
R
N
---
L
K
F
P
P
L
F
T
Q
-
K
Y
P
C
E
-----
Y
V
M
V
Q
D
M
L
S
P
S
P
M
E
R
P
E
A
I
N
I
I
E
N
A
V
F
E
D
L
D
F
P
G
K
T
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
47.82
36%
-25
- C2 -
4X7K
3
A:
[106-300]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
L
Y
I
Q
M
Q
L
C
R
K
E
N
L
K
D
W
M
N
G
R
C
T
I
E
E
-----
R
E
R
S
V
C
L
H
I
F
L
Q
I
A
E
A
V
E
F
L
H
S
K
G
L
M
H
R
N
L
K
P
S
N
I
F
F
T
M
D
D
V
V
K
V
G
D
F
G
L
V
T
--------------------------------
T
K
L
Y
M
S
P
E
Q
I
H
G
N
S
---
Y
S
H
K
V
D
I
F
S
L
G
L
I
L
F
E
L
L
--------
Y
-
P
F
S
T
Q
M
E
R
V
R
T
L
T
D
V
R
N
---
L
K
F
P
P
L
F
T
Q
-
K
Y
P
C
E
-----
Y
V
M
V
Q
D
M
L
S
P
S
P
M
E
R
P
E
A
I
N
I
I
E
N
A
V
F
E
D
L
D
F
P
G
K
T
V
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
47.06
36%
-26
- C2 -
4X7H
1
A:
[106-300]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
L
Y
I
Q
M
Q
L
C
R
K
E
N
L
K
D
W
M
N
G
R
C
T
I
E
E
-----
R
E
R
S
V
C
L
H
I
F
L
Q
I
A
E
A
V
E
F
L
H
S
K
G
L
M
H
R
N
L
K
P
S
N
I
F
F
T
M
D
D
V
V
K
V
G
D
F
-----------------------------------
G
T
K
L
Y
M
S
P
E
Q
I
H
G
N
S
---
Y
S
H
K
V
D
I
F
S
L
G
L
I
L
F
E
L
L
--------
Y
-
P
F
S
T
Q
M
E
R
V
R
T
L
T
D
V
R
N
---
L
K
F
P
P
L
F
T
Q
-
K
Y
P
C
E
-----
Y
V
M
V
Q
D
M
L
S
P
S
P
M
E
R
P
E
A
I
N
I
I
E
N
A
V
F
E
D
L
D
F
P
G
K
T
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
46.93
36%
-26
- C2 -
4X7L
3
A:
[106-300]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
L
Y
I
Q
M
Q
L
C
R
K
E
N
L
K
D
W
M
N
G
R
C
T
I
E
E
-----
R
E
R
S
V
C
L
H
I
F
L
Q
I
A
E
A
V
E
F
L
H
S
K
G
L
M
H
R
N
L
K
P
S
N
I
F
F
T
M
D
D
V
V
K
V
G
D
F
G
L
V
T
--------------------------------
T
K
L
Y
M
S
P
E
Q
I
H
G
N
S
---
Y
S
H
K
V
D
I
F
S
L
G
L
I
L
F
E
L
L
--------
Y
-
P
F
S
T
Q
M
E
R
V
R
T
L
T
D
V
R
N
---
L
K
F
P
P
L
F
T
Q
-
K
Y
P
C
E
-----
Y
V
M
V
Q
D
M
L
S
P
S
P
M
E
R
P
E
A
I
N
I
I
E
N
A
V
F
E
D
L
D
F
P
G
K
T
V
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
46.71
36%
-24
- C2 -
4X7N
2
A:
[106-300]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
L
Y
I
Q
M
Q
L
C
R
K
E
N
L
K
D
W
M
N
G
R
C
T
I
E
E
-----
R
E
R
S
V
C
L
H
I
F
L
Q
I
A
E
A
V
E
F
L
H
S
K
G
L
M
H
R
N
L
K
P
S
N
I
F
F
T
M
D
D
V
V
K
V
G
D
F
G
L
V
T
--------------------------------
T
K
L
Y
M
S
P
E
Q
I
H
G
N
S
---
Y
S
H
K
V
D
I
F
S
L
G
L
I
L
F
E
L
L
--------
Y
-
P
F
S
T
Q
M
E
R
V
R
T
L
T
D
V
R
N
---
L
K
F
P
P
L
F
T
Q
-
K
Y
P
C
E
-----
Y
V
M
V
Q
D
M
L
S
P
S
P
M
E
R
P
E
A
I
N
I
I
E
N
A
V
F
E
D
L
D
F
P
G
K
T
V
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
45.92
36%
-33
- C2 -
4X7O
1
A:
[106-300]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
L
Y
I
Q
M
Q
L
C
R
K
E
N
L
K
D
W
M
N
G
R
C
T
I
E
E
-----
R
E
R
S
V
C
L
H
I
F
L
Q
I
A
E
A
V
E
F
L
H
S
K
G
L
M
H
R
N
L
K
P
S
N
I
F
F
T
M
D
D
V
V
K
V
G
D
F
-----------------------------------
G
T
K
L
Y
M
S
P
E
Q
I
H
------
Y
S
H
K
V
D
I
F
S
L
G
L
I
L
F
E
L
L
--------
Y
-
P
F
S
T
Q
M
E
R
V
R
T
L
T
D
V
R
N
---
L
K
F
P
P
L
F
T
Q
-
K
Y
P
C
E
-----
Y
V
M
V
Q
D
M
L
S
P
S
P
M
E
R
P
E
A
I
N
I
I
E
N
A
V
F
E
D
L
D
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
45.49
34%
-35
- C2 -
2A19
1
E2AK2_HUMAN
B:
[70-274]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
G
C
W
D
G
F
D
YD---------
R
S
K
T
K
C
L
F
I
Q
M
E
F
C
D
K
G
T
L
E
Q
------
W
I
E
K
R
R
G
E
K
L
D
K
V
L
A
L
E
L
F
E
Q
I
T
K
G
V
D
Y
I
H
S
K
K
L
I
N
R
D
L
K
P
S
N
I
F
L
V
D
T
K
Q
V
K
I
G
D
F
G
L
V
T
S
-----------------
L
K
N
D
--
G
K
R
T
R
S
K
G
T
L
R
Y
M
S
P
E
-
Q
I
S
S
--
Q
D
Y
G
K
E
V
D
L
Y
A
L
G
L
I
L
A
E
L
---------
L
H
V
C
D
T
A
F
E
T
S
K
F
F
T
D
L
R
D
G
I
---
I
S
D
I
F
D
----
K
K
E
-----
K
T
L
L
Q
K
L
L
S
K
K
P
E
D
R
P
N
T
S
E
I
L
R
T
L
T
V
W
K
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
40.94
33%
-16
- C2 -
2A19
1
E2AK2_HUMAN
C:
[70-274]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
G
C
W
D
G
F
D
YDPET
S
-------
K
T
K
C
L
F
I
Q
M
E
F
C
D
K
G
T
L
---------------------
L
A
L
E
L
F
E
Q
I
T
K
G
V
D
Y
I
H
S
K
K
L
I
N
R
D
L
K
P
S
N
I
F
L
V
D
T
K
Q
V
K
I
G
D
F
G
L
V
---------------------------------------------------
G
K
E
V
D
L
Y
A
L
G
L
I
L
A
E
L
---------
L
------------------
G
I
---
I
S
D
I
F
D
----
K
K
E
-----
K
T
L
L
Q
K
L
L
S
K
K
P
E
D
R
P
N
T
S
E
I
L
R
T
L
T
V
W
K
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
78
PsiBlast_CBE
40.13
31%
-26
- C2 -
4NZW
1
STK25_HUMAN
B:
[93-286]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
------
L
L
K
P
--
G
P
L
E
E
T
Y
-
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
R
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
Q
G
D
V
K
L
A
A
F
G
V
A
----------------
G
----------------
T
P
F
W
M
A
P
E
-
V
--
I
K
Q
--
Y
D
F
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
K
GEPPNSD
L
H
P
M
R
V
----
L
F
L
I
P
K
N
S
P
P
T
L
--------
E
G
Q
H
S
K
P
F
----
K
E
F
V
E
A
C
L
N
K
D
P
R
F
R
P
T
A
K
E
L
L
K
H
K
F
I
T
R
Y
T
K
K
T
S
F
L
T
E
L
I
D
R
Y
K
R
W
K
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
33
PsiBlast_CBE
36.92
31%
-29
- C2 -
4FZF
1
?
B:
[81-274]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
------
L
L
R
A
--
G
P
F
-
D
E
F
Q
I
A
T
M
L
K
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
Q
G
D
V
K
L
A
A
F
G
V
A
----------------
G
Q
L
--
T
D
T
Q
I
K
R
N
T
F
V
G
T
P
F
W
M
A
P
E
-
V
--
I
Q
Q
S
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
KGEPPNSD
M
H
P
M
-----
R
V
L
F
L
I
P
K
N
N
P
--
P
T
L
V
G
D
F
T
K
S
----
F
-----
K
E
F
I
D
A
C
L
N
K
D
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
V
K
N
S
K
K
T
S
Y
L
T
E
L
I
D
R
F
K
R
W
K
A
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
35
PsiBlast_CBE
36.14
31%
-23
- C2 -
4FZA
3
STK26_HUMAN
B:
[81-274]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
------
L
L
R
A
--
G
P
F
-
D
E
F
Q
I
A
T
M
L
K
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
Q
G
D
V
K
L
A
A
F
G
V
A
----------------
G
Q
L
--
T
D
T
Q
I
K
R
N
T
F
V
G
T
P
F
W
M
A
P
E
-
V
--
I
Q
Q
S
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
K
GEPPNSD
M
H
P
M
-----
R
V
L
F
L
I
P
K
N
N
P
--
P
T
L
V
G
D
F
T
K
S
----
F
-----
K
E
F
I
D
A
C
L
N
K
D
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
V
K
N
S
K
K
T
S
Y
L
T
E
L
I
D
R
F
K
R
W
K
A
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
32
PsiBlast_CBE
31.57
33%
-10
- C2 -
3DAK
1
OXSR1_HUMAN
A:
[121-286]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
L
R
E
V
L
E
G
L
E
Y
L
H
K
N
G
Q
I
H
R
D
V
K
A
G
N
I
L
L
G
E
D
G
S
V
Q
I
A
D
F
G
V
S
----
A
F
L
A
T
G
------
G
--------------
V
G
T
P
C
W
M
A
P
E
-
V
M
E
Q
V
R
-
G
Y
D
F
K
A
D
I
W
S
F
G
I
T
A
I
E
L
A
TGAAPYHK
Y
P
P
M
-----
K
V
L
M
L
T
L
Q
N
D
P
--
P
S
L
E
T
G
V
Q
D
K
E
M
L
K
K
YG
K
S
F
R
K
M
I
S
L
C
L
Q
K
D
P
E
K
R
P
T
A
A
E
L
L
R
H
K
F
F
Q
K
A
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
30
PsiBlast_CBE
31.32
33%
-3
- C2 -
3DAK
1
OXSR1_HUMAN
C:
[121-286]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
L
R
E
V
L
E
G
L
E
Y
L
H
K
N
G
Q
I
H
R
D
V
K
A
G
N
I
L
L
G
E
D
G
S
V
Q
I
A
D
F
G
V
S
----
A
F
L
A
T
G
------
G
D
-----------
T
F
V
G
T
P
C
W
M
A
P
E
-
V
M
E
Q
V
R
-
G
Y
D
F
K
A
D
I
W
S
F
G
I
T
A
I
E
L
A
TGAAPYHK
Y
P
P
M
-----
K
V
L
M
L
T
L
Q
N
D
P
--
P
S
L
E
T
G
V
Q
D
K
E
M
L
K
K
YG
K
S
F
R
K
M
I
S
L
C
L
Q
K
D
P
E
K
R
P
T
A
A
E
L
L
R
H
K
F
F
Q
K
A
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
31
PsiBlast_CBE
30.90
33%
-8
- C2 -
3DAK
1
OXSR1_HUMAN
B:
[121-286]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
L
R
E
V
L
E
G
L
E
Y
L
H
K
N
G
Q
I
H
R
D
V
K
A
G
N
I
L
L
G
E
D
G
S
V
Q
I
A
D
F
G
V
S
----
A
F
L
A
T
G
------
G
D
---------------
T
P
C
W
M
A
P
E
-
V
M
E
Q
V
R
-
G
Y
D
F
K
A
D
I
W
S
F
G
I
T
A
I
E
L
A
TGAAPYHK
Y
P
P
M
-----
K
V
L
M
L
T
L
Q
N
D
P
--
P
S
L
E
T
G
V
Q
D
K
E
M
L
K
K
YG
K
S
F
R
K
M
I
S
L
C
L
Q
K
D
P
E
K
R
P
T
A
A
E
L
L
R
H
K
F
F
Q
K
A
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
PsiBlast_CBE
29.72
32%
-10
- C2 -
2VWI
1
OXSR1_HUMAN
D:
[126-298]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
L
R
E
V
L
E
G
L
E
Y
L
H
K
N
G
Q
I
H
R
D
V
K
A
G
N
I
L
L
G
E
D
G
S
V
Q
I
A
D
F
G
V
S
----
A
F
L
A
T
G
------
G
------------
T
F
V
G
T
P
C
W
M
A
P
E
-
V
M
E
Q
V
R
-
G
Y
D
F
K
A
D
I
W
S
F
G
I
T
A
I
E
L
A
TGAAPYHK
Y
P
P
M
-----
K
V
L
M
L
T
L
Q
N
D
P
--
P
S
L
E
T
G
V
Q
D
K
E
M
L
K
K
YG
K
S
F
R
K
M
I
S
L
C
L
Q
K
D
P
E
K
R
P
T
A
A
E
L
L
R
H
K
F
F
Q
K
A
K
N
K
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
29
PsiBlast_CBE
27.55
33%
-7
- C2 -
3DAK
1
OXSR1_HUMAN
D:
[121-286]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
L
R
E
V
L
E
G
L
E
Y
L
H
K
N
G
Q
I
H
R
D
V
K
A
G
N
I
L
L
G
E
D
G
S
V
Q
I
A
D
F
G
V
S
----
A
F
L
A
T
G
------
G
D
I
T
R
N
--------
F
V
G
T
P
C
W
M
A
P
E
-
V
M
E
Q
V
R
-
G
Y
D
F
K
A
D
I
W
S
F
G
I
T
A
I
E
L
A
TGAAPYHK
Y
P
P
M
-----
K
V
L
M
L
T
L
Q
N
D
P
--
P
S
L
E
T
G
V
Q
D
K
E
M
L
K
K
YG
K
S
F
R
K
M
I
S
L
C
L
Q
K
D
P
E
K
R
P
T
A
A
E
L
L
R
H
K
F
F
Q
K
A
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
PsiBlast_CBE
26.06
32%
-5
- C2 -
2VWI
1
OXSR1_HUMAN
B:
[126-292]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
L
R
E
V
L
E
G
L
E
Y
L
H
K
N
G
Q
I
H
R
D
V
K
A
G
N
I
L
L
G
E
D
G
S
V
Q
I
A
D
F
G
V
S
----
A
F
L
A
T
G
------
G
D
---------------
T
P
C
W
M
A
P
E
-
V
M
E
Q
V
R
-
G
Y
D
F
K
A
D
I
W
S
F
G
I
T
A
I
E
L
A
TGAAPYHK
Y
P
P
M
-----
K
V
L
M
L
T
L
Q
N
D
P
--
P
S
L
E
T
G
-----
M
L
K
K
YGK
S
F
R
K
M
I
S
L
C
L
Q
K
D
P
E
K
R
P
T
A
A
E
L
L
R
H
K
F
F
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------