@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : EGFR_HUMAN: (2015-10-07 )
MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA
Atome Classification :
(68 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730-.......740.......750.......760.......770.......780..--.....790.......800....-...810.......820.......830.......840.......850.......860.......870.......880.......890.......900.......910.......920.......930.......940.......950.......960.......970.......980.......990.......1000......1010......1020......1030......1040......1050......1060......1070......1080......1090......1100......1110......1120......1130......1140......1150......1160......1170......1180......1190......1200......1210
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MRPSGT
A
G
A
A
L
L
A
L
L
A
A
LCP
A
S
R
A
L
E
E
K
K
V
CQGTSNK
L
T
QLGT
F
E
D
H
F
L
S
L
Q
R
M
FNN
C
E
V
V
LGN
L
E
I
T
Y
V
QRNY
D
L
S
F
L
K
T
I
Q
E
VA
G
Y
V
L
I
A
LN
T
V
E
RIPLE
N
L
Q
I
I
RG
N
M
Y
YEN
S
Y
A
L
A
V
L
SNYDANKT
G
L
K
EL
P
M
R
N
L
Q
E
I
L
H
G
A
VRFSNNPALCNVES
I
Q
W
R
D
I
V
S
S
D
F
L
S
N
M
S
M
D
F
Q
N
HLGSCQKCDPSCPNGSCWGA
G
E
E
N
C
Q
K
L
T
K
I
I
C
A
Q
QCSGRCRGK
S
P
S
D
C
C
H
N
Q
CAAGCTGPRES
D
C
L
V
C
R
K
FRDEATCKDTCP
P
L
M
L
YNP
T
T
Y
Q
M
DVNPEGKYS
F
G
A
T
C
V
K
KCPR
N
Y
V
VTDHG
S
C
V
R
ACGADSYE
M
E
E
D
G
V
R
K
C
K
KCEG
P
C
R
K
V
CNGIGIGEFKDSLSIN
A
T
N
I
K
H
F
K
N
C
TSISG
D
L
H
I
L
P
V
A
FRGDSFTHTPPL
D
P
Q
E
L
D
I
L
K
T
V
K
E
I
T
G
F
L
L
I
Q
AWPENRTD
L
H
A
FEN
L
E
I
IRGRTKQHG
Q
F
S
L
A
V
V
S
L
N
I
T
S
L
G
L
R
S
L
K
EISDG
D
V
I
I
SGNK
N
L
C
Y
ANTI
N
W
K
K
LFGTSG
Q
K
T
K
I
ISNRGEN
S
C
K
A
T
G
Q
V
C
H
A
LCSPEGCWGPEP
R
D
C
V
S
C
RNVS
R
G
R
E
C
V
D
K
CNLLEG
E
P
R
E
F
VENS
E
C
IQC
H
P
E
CLPQA
M
N
I
T
C
TGRG
P
D
N
C
I
Q
C
A
HYIDGP
H
C
V
K
TCPAGVMGEN
N
T
L
V
W
K
YADAG
H
V
C
HLCHPNCTYGCTGPGLEGCPTNGPKI
P
S
I
A
T
G
M
V
G
A
L
L
L
L
L
V
V
A
L
G
I
G
L
F
M
R
R
R
H
I
V
R
K
R
T
L
R
R
L
L
Q
E
R
E
LVEPLTPSGEA
P
N
Q
A
L
L
R
I
L
K
ETE
F
K
K
I
K
V
LGSGA
F
G
T
V
YK
G
L
WI-PEG
E
K
V
K
I
P
V
A
I
K
E
L
R
E
ATSPKA
N
K
E
I
L
D
E
A
Y
V
M
ASVD
N
P
H
V
C
R
L
L
G
I
C
L
T
S
--
T
V
Q
L
I
T
Q
LM
P
F
G
C
L
L
D
Y
V
R
E
H
K
-DNI
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
GM
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
AR
N
V
L
VKTP
Q
H
V
K
I
T
D
F
G
L
A
K
L
LGAE
E
K
E
YHAEGGKV
P
I
K
W
M
A
L
E
S
I
L
H
R
I
YTHQS
D
V
W
S
Y
G
V
T
V
W
E
L
M
TFGSKPYDGI
P
A
S
E
I
S
S
I
L
E
K
G
ERLPQPP
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
IDADSR
P
K
F
R
E
L
I
I
E
F
S
K
MARDP
Q
R
Y
L
V
I
QGDERMHLPSPTD
S
N
F
Y
R
A
LMDEE
D
M
D
D
VVDADEYLIPQQGFFSSPSTSRT
P
L
L
S
S
LSATSNN
S
T
V
A
C
I
DRNGLQSCPIK
E
D
S
F
L
Q
R
YSSDPTGALTEDSIDDTFLP
V
P
E
Y
I
N
QSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNP
E
Y
LNTVQPTCVNSTFDS
P
A
H
W
A
QKGS
H
Q
I
SLDNP
D
Y
Q
QDFFPKEAKPNG
I
F
KGSTAENA
E
Y
L
R
VAPQSSEFIGA
75
PsiBlast_CBE
72.33
100%
-123
- C2 -
2RGP
1
A:
[1-315]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
L
L
R
I
L
K
E
T
E
F
K
K
I
K
V
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
I
-
P
----
V
K
I
P
V
A
I
K
E
L
R
-----
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
L
T
S
--
T
V
Q
L
I
T
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
H
K
-
D
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
A
K
L
L
G
A
E
E
K
--------
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
S
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
D
E
R
M
--------
N
F
Y
R
A
L
M
D
------
V
V
D
A
D
E
Y
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
33
PsiBlast_CBE
72.21
100%
-120
- C2 -
3W2S
1
A:
[9-327]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
A
L
L
R
I
L
K
E
T
E
F
K
K
I
K
V
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
I
-
P
E
G
E
K
V
K
I
P
V
A
I
K
E
L
R
E
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
L
T
S
--
T
V
Q
L
I
T
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
H
K
-
D
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
A
K
L
L
------------
K
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
S
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
D
E
R
M
H
L
P
S
P
T
D
S
N
F
Y
R
A
L
M
D
E
E
D
M
D
D
V
V
D
A
D
E
Y
L
I
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
32
PsiBlast_CBE
72.08
100%
-111
- C2 -
3W32
1
A:
[9-325]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
A
L
L
R
I
L
K
E
T
E
F
K
K
I
K
V
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
I
-
P
E
G
E
K
V
K
I
P
V
A
I
K
E
L
R
E
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
L
T
S
--
T
V
Q
L
I
T
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
H
K
-
D
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
A
K
L
L
G
A
E
E
K
E
Y
H
A
E
G
G
K
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
S
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
D
E
R
M
H
L
P
S
P
T
D
S
N
F
Y
R
A
L
M
D
E
E
D
M
D
D
V
V
D
A
D
E
Y
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
31
PsiBlast_CBE
72.08
100%
-121
- C2 -
3W33
1
A:
[9-326]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
A
L
L
R
I
L
K
E
T
E
F
K
K
I
K
V
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
I
-
P
E
G
E
K
V
K
I
P
V
A
I
K
E
L
R
-----
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
L
T
S
--
T
V
Q
L
I
T
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
H
K
-
D
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
A
K
L
L
------------
K
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
S
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
D
E
R
M
H
L
P
S
P
T
D
S
N
F
Y
R
A
L
M
D
----
D
D
V
V
D
A
D
E
Y
L
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
56
PsiBlast_CBE
71.80
99%
-111
- C2 -
5CNO
1
?
B:
[6-323]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
P
N
Q
A
L
L
R
I
L
K
E
T
E
F
K
K
I
K
V
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
I
-
P
E
G
E
K
V
K
I
P
V
A
I
K
E
L
R
E
----
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
L
T
S
--
T
V
Q
L
I
T
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
H
K
-
D
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
A
K
L
L
------------
K
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
R
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
S
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
D
E
R
M
H
L
P
S
P
T
D
S
N
F
Y
R
A
L
M
D
E
E
D
M
D
D
V
V
D
A
D
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
62
PsiBlast_CBE
71.48
100%
-113
- C2 -
4JR3
1
A:
[3-326]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
E
A
P
N
Q
A
L
L
R
I
L
K
E
T
E
F
K
K
I
K
V
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
I
-
P
E
G
E
K
V
K
I
P
V
A
I
K
E
L
R
E
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
L
T
S
--
T
V
Q
L
I
T
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
H
K
-
D
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
A
K
L
L
G
A
E
E
K
E
Y
H
A
E
G
G
K
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
S
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
D
---------------------
D
M
D
D
V
V
D
A
D
E
Y
L
I
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
45
PsiBlast_CBE
71.35
99%
-115
- C2 -
3VJN
1
A:
[9-330]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
A
P
N
Q
A
L
L
R
I
L
K
E
T
E
F
K
K
I
K
V
L
S
S
---
G
T
V
Y
K
G
L
W
I
-
P
E
G
E
K
V
K
I
P
V
A
I
K
E
L
-
E
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
L
T
S
--
T
V
Q
L
I
M
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
H
K
-
D
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
A
K
L
L
G
A
E
E
K
E
Y
H
A
E
G
G
K
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
S
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
D
---------------------
D
M
D
D
V
V
D
A
D
E
Y
L
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
34
PsiBlast_CBE
71.35
100%
-121
- C2 -
3POZ
1
A:
[6-322]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
A
L
L
R
I
L
K
E
T
E
F
K
K
I
K
V
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
I
-
P
----
V
K
I
P
V
A
I
K
E
L
-------
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
L
T
S
--
T
V
Q
L
I
T
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
H
K
-
D
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
A
K
L
L
G
A
E
E
K
-------
K
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
S
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
D
E
R
M
H
L
P
S
P
T
D
S
N
F
Y
R
A
L
M
D
------
V
V
D
A
D
E
Y
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
70
PsiBlast_CBE
71.25
99%
-112
- C2 -
3W2O
1
A:
[7-326]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
P
N
Q
A
L
L
R
I
L
K
E
T
E
F
K
K
I
K
V
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
I
-
P
E
G
E
K
V
K
I
P
V
A
I
K
E
L
R
E
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
L
T
S
--
T
V
Q
L
I
M
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
H
K
-
D
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
R
A
K
L
L
G
A
E
E
K
E
Y
H
A
E
G
G
K
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
S
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
D
E
R
M
H
L
P
----------------
M
D
D
V
V
D
A
D
E
Y
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
63
PsiBlast_CBE
71.23
100%
-113
- C2 -
4JQ8
1
A:
[3-326]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
E
A
P
N
Q
A
L
L
R
I
L
K
E
T
E
F
K
K
I
K
V
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
I
-
P
E
G
E
K
V
K
I
P
V
A
I
K
E
L
R
E
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
L
T
S
--
T
V
Q
L
I
T
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
H
K
-
D
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
A
K
L
L
G
A
E
E
K
E
Y
H
A
E
G
G
K
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
S
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
D
---------------------
D
M
D
D
V
V
D
A
D
E
Y
L
I
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
61
PsiBlast_CBE
71.21
100%
-114
- C2 -
4JRV
1
A:
[3-326]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
E
A
P
N
Q
A
L
L
R
I
L
K
E
T
E
F
K
K
I
K
V
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
I
-
P
E
G
E
K
V
K
I
P
V
A
I
K
E
L
---
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
L
T
S
--
T
V
Q
L
I
T
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
H
K
-
D
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
A
K
L
L
G
A
E
E
K
E
Y
H
A
E
G
G
K
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
S
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
D
---------------------
D
M
D
D
V
V
D
A
D
E
Y
L
I
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
64
PsiBlast_CBE
71.19
100%
-109
- C2 -
4JQ7
1
A:
[3-326]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
E
A
P
N
Q
A
L
L
R
I
L
K
E
T
E
F
K
K
I
K
V
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
I
-
P
E
G
E
K
V
K
I
P
V
A
I
K
E
L
R
E
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
L
T
S
--
T
V
Q
L
I
T
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
H
K
-
D
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
A
K
L
L
G
A
E
E
K
E
Y
H
A
E
G
G
K
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
S
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
D
---------------------
D
M
D
D
V
V
D
A
D
E
Y
L
I
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
81
PsiBlast_CBE
70.89
99%
-114
- C2 -
4WRG
1
A:
[4-327]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
E
A
P
N
Q
A
L
L
R
I
L
K
E
T
E
F
K
K
I
K
V
L
G
-----
T
V
Y
K
G
L
W
I
-
P
E
G
E
K
V
K
I
P
V
A
I
K
E
-----
S
P
K
-
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
L
T
S
---
V
Q
L
I
T
Q
L
M
P
F
G
-
L
L
D
Y
V
R
E
H
K
-
D
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
A
K
L
L
G
A
E
E
K
E
Y
H
A
E
--
K
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
S
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
----------------------
D
M
D
D
V
V
D
A
D
E
Y
L
I
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
PsiBlast_CBE
70.59
99%
-107
- C2 -
5CNN
1
?
B:
[8-322]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
Q
A
L
L
R
Q
L
K
E
T
E
F
K
K
I
K
V
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
I
-
P
E
G
E
K
V
K
I
P
V
A
I
K
E
L
R
E
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
L
T
S
--
T
V
Q
L
I
T
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
H
K
-
D
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
A
K
L
L
G
-----------
K
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
S
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
D
E
R
M
H
L
P
S
P
T
D
S
N
F
Y
R
A
L
M
D
E
E
D
M
D
D
V
V
D
A
D
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
44
PsiBlast_CBE
70.57
99%
-109
- C2 -
4G5P
1
EGFR_HUMAN
A:
[4-324]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
E
A
P
N
Q
A
L
L
R
I
L
K
E
T
E
F
K
K
I
K
V
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
I
-
P
E
G
E
K
V
K
I
P
V
A
I
K
E
L
R
E
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
L
T
S
--
T
V
Q
L
I
M
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
H
K
-
D
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
A
K
L
L
G
A
E
E
K
E
Y
H
A
E
G
G
K
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
S
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
D
E
R
----------------------
D
V
V
D
A
D
E
Y
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
59
PsiBlast_CBE
70.56
99%
-115
- C2 -
2GS7
1
B:
[9-324]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
A
L
L
R
I
L
K
E
T
E
F
K
K
I
K
V
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
I
-
P
E
G
E
K
V
K
I
P
V
A
I
K
E
L
R
E
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
L
T
S
--
T
V
Q
L
I
T
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
H
K
-
D
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
A
K
L
L
G
A
E
E
K
E
Y
H
A
---
K
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
R
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
S
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
-------------------------
D
V
V
D
A
D
E
Y
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
40
PsiBlast_CBE
70.53
100%
-106
- C2 -
2GS6
1
A:
[4-327]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
E
A
P
N
Q
A
L
L
R
I
L
K
E
T
E
F
K
K
I
K
V
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
I
-
P
E
G
E
K
V
K
I
P
V
A
I
K
E
L
---
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
L
T
S
--
T
V
Q
L
I
T
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
H
K
-
D
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
A
K
L
L
G
A
E
E
K
E
Y
H
A
E
G
G
K
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
S
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
D
E
R
M
H
L
P
S
-------------
E
D
M
D
D
V
V
D
A
D
E
Y
L
I
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
82
PsiBlast_CBE
70.49
99%
-112
- C2 -
4WKQ
2
A:
[4-328]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
E
A
P
N
Q
A
L
L
R
I
L
K
E
T
E
F
K
K
I
K
V
L
G
S
---
G
T
V
Y
K
G
L
W
I
-
P
E
G
E
K
V
K
I
P
V
A
I
K
E
-----
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
L
T
S
--
T
V
Q
L
I
T
Q
L
M
P
F
G
-
L
L
D
Y
V
R
E
H
K
-
D
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
A
K
L
L
G
A
E
E
K
E
Y
H
A
E
G
G
K
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
S
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
----------------------
D
M
D
D
V
V
D
A
D
E
Y
L
I
P
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
51
PsiBlast_CBE
70.43
99%
-114
- C2 -
2ITN
1
A:
[1-324]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
E
A
P
N
Q
A
L
L
R
I
L
K
E
T
E
F
K
K
I
K
V
L
S
S
G
A
F
G
T
V
Y
K
G
L
W
I
-
P
E
G
E
K
V
K
I
P
V
A
I
K
E
L
R
E
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
L
T
S
--
T
V
Q
L
I
T
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
H
K
-
D
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
A
K
L
L
G
A
E
E
---------
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
S
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
D
E
R
M
H
L
-----------
L
M
D
E
E
D
M
D
D
V
V
D
A
D
E
Y
L
I
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
70.42
100%
-109
- C2 -
1M17
1
A:
[7-330]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
E
A
P
N
Q
A
L
L
R
I
L
K
E
T
E
F
K
K
I
K
V
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
I
-
P
E
G
E
K
V
K
I
P
V
A
I
K
E
L
R
E
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
L
T
S
--
T
V
Q
L
I
T
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
H
K
-
D
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
A
K
L
L
G
A
E
E
K
E
Y
H
A
E
G
G
K
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
S
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
D
E
R
M
H
L
------------
M
D
E
E
D
M
D
D
V
V
D
A
D
E
Y
L
I
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
57
PsiBlast_CBE
70.30
99%
-111
- C2 -
5CNO
1
?
A:
[8-323]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
Q
A
L
L
R
I
L
K
E
T
E
F
K
K
I
K
V
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
I
-
P
E
G
E
K
V
K
I
P
V
A
I
K
E
L
R
E
A
-----
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
L
T
S
--
T
V
Q
L
I
T
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
H
K
-
D
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
A
K
L
L
G
-----------
K
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
R
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
S
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
D
E
R
M
H
L
P
S
P
T
D
S
N
F
Y
R
A
L
M
D
E
E
D
M
D
D
V
V
D
A
D
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
43
PsiBlast_CBE
70.24
99%
-111
- C2 -
4I24
1
EGFR_HUMAN
A:
[7-321]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
Q
A
L
L
R
I
L
K
E
T
E
F
K
K
I
K
V
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
I
-
P
E
G
E
K
V
K
I
P
V
A
I
K
E
L
-------
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
L
T
S
--
T
V
Q
L
I
M
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
H
K
-
D
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
A
K
L
L
-------------
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
S
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
D
E
R
M
H
L
P
S
P
T
D
S
N
F
Y
R
A
L
M
D
E
E
D
M
D
D
V
V
D
A
D
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
58
PsiBlast_CBE
70.14
99%
-118
- C2 -
3GT8
1
EGFR_HUMAN
C:
[7-315]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
N
Q
A
L
L
R
I
L
K
E
T
E
F
K
K
I
K
V
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
I
-
P
E
G
E
K
V
K
I
P
V
A
I
K
E
L
R
E
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
L
T
S
--
T
V
Q
L
I
T
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
H
K
-
D
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
A
K
L
L
-------------
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
R
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
S
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
D
E
R
M
H
L
P
S
P
T
D
S
N
F
Y
R
A
L
M
D
E
E
D
M
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
69
PsiBlast_CBE
70.13
99%
-111
- C2 -
3W2P
1
A:
[7-327]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
P
N
Q
A
L
L
R
I
L
K
E
T
E
F
K
K
I
K
V
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
I
-
P
E
G
E
K
V
K
I
P
V
A
I
K
E
L
R
E
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
L
T
S
--
T
V
Q
L
I
M
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
H
K
-
D
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
R
A
K
L
L
G
A
E
E
K
E
Y
H
A
E
G
G
K
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
S
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
D
E
R
M
H
L
P
S
--------------
D
M
D
D
V
V
D
A
D
E
Y
L
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
68
PsiBlast_CBE
70.13
99%
-111
- C2 -
3W2Q
2
A:
[7-326]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
P
N
Q
A
L
L
R
I
L
K
E
T
E
F
K
K
I
K
V
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
I
-
P
E
G
E
K
V
K
I
P
V
A
I
K
E
L
R
E
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
L
T
S
--
T
V
Q
L
I
M
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
H
K
-
D
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
R
A
K
L
L
G
A
E
E
K
E
Y
H
A
E
G
G
K
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
S
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
D
E
R
M
H
L
P
S
P
--------------
M
D
D
V
V
D
A
D
E
Y
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
38
PsiBlast_CBE
70.06
100%
-109
- C2 -
2ITX
1
A:
[2-324]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
A
P
N
Q
A
L
L
R
I
L
K
E
T
E
F
K
K
I
K
V
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
I
-
P
E
G
E
K
V
K
I
P
V
A
I
K
E
L
R
E
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
L
T
S
--
T
V
Q
L
I
T
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
H
K
-
D
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
A
K
L
----
E
K
E
Y
H
A
E
G
G
K
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
S
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
D
E
R
M
H
L
------------
M
D
E
E
D
M
D
D
V
V
D
A
D
E
Y
L
I
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
70.06
99%
-101
- C2 -
3IKA
1
EGFR_HUMAN
A:
[5-329]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
E
A
P
N
Q
A
L
L
R
I
L
K
E
T
E
F
K
K
I
K
V
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
I
-
P
E
G
E
K
V
K
I
P
V
A
I
K
E
L
R
E
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
L
T
S
--
T
V
Q
L
I
M
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
H
K
-
D
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
A
K
L
L
G
A
E
E
K
E
Y
H
A
E
G
G
K
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
S
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
D
E
R
M
H
---------------
E
E
D
M
D
D
V
V
D
A
D
E
Y
L
I
P
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28
PsiBlast_CBE
70.03
100%
-122
- C2 -
1XKK
1
A:
[32-348]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
L
L
R
I
L
K
E
T
E
F
K
K
I
K
V
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
I
-
P
----
V
K
I
P
V
A
I
K
E
L
R
E
----
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
L
T
S
--
T
V
Q
L
I
T
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
H
K
-
D
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
A
K
L
L
G
A
E
E
K
--------
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
S
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
D
E
R
M
-------
S
N
F
Y
R
A
L
M
D
E
-----
V
V
D
A
D
E
Y
L
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
54
PsiBlast_CBE
69.99
99%
-111
- C2 -
2ITU
1
A:
[1-324]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
E
A
P
N
Q
A
L
L
R
I
L
K
E
T
E
F
K
K
I
K
V
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
I
-
P
E
G
E
K
V
K
I
P
V
A
I
K
E
L
R
E
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
L
T
S
--
T
V
Q
L
I
T
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
H
K
-
D
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
R
A
K
L
L
G
A
E
----------
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
S
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
D
E
R
M
H
L
P
S
----------
M
D
E
E
D
M
D
D
V
V
D
A
D
E
Y
L
I
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
PsiBlast_CBE
69.96
99%
-110
- C2 -
4RIX
1
D:
[11-307]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
V
E
P
L
T
P
S
G
E
A
P
N
Q
A
L
L
R
I
L
K
E
T
E
F
K
K
I
K
V
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
I
-
P
E
G
E
K
V
K
I
P
V
A
I
K
E
L
R
E
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
L
T
S
--
T
V
Q
L
I
T
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
H
K
-
D
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
A
K
L
L
G
A
E
E
K
E
Y
H
A
E
G
G
K
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
R
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
S
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
D
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
69.94
100%
-107
- C2 -
4I23
1
A:
[2-325]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
G
E
A
P
N
Q
A
L
L
R
I
L
K
E
T
E
F
K
K
I
K
V
L
G
S
---
G
T
V
Y
K
G
L
W
I
-
P
E
G
E
K
V
K
I
P
V
A
I
K
E
L
--
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
L
T
S
--
T
V
Q
L
I
T
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
H
K
-
D
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
A
K
L
L
G
A
E
E
K
E
Y
H
A
E
G
G
K
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
S
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
D
E
R
M
H
L
P
---------------
D
M
D
D
V
V
D
A
D
E
Y
L
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
46
PsiBlast_CBE
69.90
99%
-113
- C2 -
3UG2
2
A:
[9-330]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
A
P
N
Q
A
L
L
R
I
L
K
E
T
E
F
K
K
I
K
V
L
S
S
---
G
T
V
Y
K
G
L
W
I
-
P
E
G
E
K
V
K
I
P
V
A
I
K
E
-----
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
L
T
S
--
T
V
Q
L
I
M
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
H
K
-
D
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
A
K
L
L
G
A
E
E
K
E
Y
H
A
E
G
G
K
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
S
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
D
E
R
M
H
L
---------------
E
D
M
D
D
V
V
D
A
D
E
Y
L
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
74
PsiBlast_CBE
69.87
100%
-121
- C2 -
3BEL
1
A:
[1-314]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
L
L
R
I
L
K
E
T
E
F
K
K
I
K
V
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
I
-
P
----
V
K
I
P
V
A
I
K
E
L
------
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
L
T
S
--
T
V
Q
L
I
T
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
H
K
-
D
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
A
K
L
L
G
A
E
E
K
--------
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
S
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
D
E
R
---------
N
F
Y
R
A
L
M
-------
V
V
D
A
D
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
69.86
99%
-109
- C2 -
4R5S
1
A:
[6-327]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
A
P
N
Q
A
L
L
R
I
L
K
E
T
E
F
K
K
I
K
V
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
I
-
P
E
G
E
K
V
K
I
P
V
A
I
K
E
L
R
E
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
L
T
S
--
T
V
Q
L
I
T
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
H
K
-
D
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
R
A
K
L
L
G
A
E
E
---------
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
S
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
D
E
R
M
H
L
P
--------------
E
D
M
D
D
V
V
D
A
D
E
Y
L
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
69.86
99%
-109
- C2 -
5CNN
1
?
A:
[7-322]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
N
Q
A
L
L
R
Q
L
K
E
T
E
F
K
K
I
K
V
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
I
-
P
E
G
E
K
V
K
I
P
V
A
I
K
E
L
R
E
A
---
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
L
T
S
--
T
V
Q
L
I
T
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
H
K
-
D
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
A
K
L
-------------
K
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
S
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
D
E
R
M
H
L
P
S
P
T
D
S
N
F
Y
R
A
L
M
D
E
E
D
M
D
D
V
V
D
A
D
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
60
PsiBlast_CBE
69.66
99%
-114
- C2 -
2GS7
1
EGFR_HUMAN
A:
[11-320]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
R
I
L
K
E
T
E
F
K
K
I
K
V
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
I
-
P
E
G
E
K
V
K
I
P
V
A
I
K
E
L
R
E
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
L
T
S
--
T
V
Q
L
I
T
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
H
K
-
D
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
A
K
L
L
G
A
E
E
K
E
Y
H
----
K
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
R
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
S
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
-------------------------
D
V
V
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
37
PsiBlast_CBE
69.61
100%
-112
- C2 -
2ITY
1
A:
[2-324]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
A
P
N
Q
A
L
L
R
I
L
K
E
T
E
F
K
K
I
K
V
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
I
-
P
E
G
E
K
V
K
I
P
V
A
I
K
E
L
R
E
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
L
T
S
--
T
V
Q
L
I
T
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
H
K
-
D
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
A
K
L
L
G
A
E
----------
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
S
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
D
E
R
M
H
L
-------------
D
E
E
D
M
D
D
V
V
D
A
D
E
Y
L
I
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
69.61
99%
-111
- C2 -
4LQM
1
A:
[6-328]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
A
P
N
Q
A
L
L
R
I
L
K
E
T
E
F
K
K
I
K
V
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
I
-
P
E
G
E
K
V
K
I
P
V
A
I
K
E
L
---
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
L
T
S
--
T
V
Q
L
I
T
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
H
K
-
D
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
R
A
K
L
L
G
A
E
E
-------
G
K
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
S
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
D
E
R
M
H
L
P
S
--------
A
L
M
D
E
E
D
M
D
D
V
V
D
A
D
E
Y
L
I
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
67
PsiBlast_CBE
69.55
99%
-111
- C2 -
4I22
1
A:
[7-321]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
Q
A
L
L
R
I
L
K
E
T
E
F
K
K
I
K
V
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
I
-
P
E
G
E
K
V
K
I
P
V
A
I
K
E
L
R
-----
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
L
T
S
--
T
V
Q
L
I
M
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
H
K
-
D
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
R
A
K
L
L
-------------
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
R
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
S
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
D
E
R
M
H
L
P
S
P
T
D
S
N
F
Y
R
A
L
M
D
E
E
D
M
D
D
V
V
D
A
D
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
53
PsiBlast_CBE
69.55
99%
-113
- C2 -
2ITV
1
A:
[1-324]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
E
A
P
N
Q
A
L
L
R
I
L
K
E
T
E
F
K
K
I
K
V
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
I
-
P
E
G
E
K
V
K
I
P
V
A
I
K
E
L
R
E
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
L
T
S
--
T
V
Q
L
I
T
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
H
K
-
D
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
R
A
K
L
L
G
A
E
E
---------
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
S
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
D
E
R
M
H
L
------------
M
D
E
E
D
M
D
D
V
V
D
A
D
E
Y
L
I
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
55
PsiBlast_CBE
69.43
99%
-112
- C2 -
2ITT
1
A:
[2-324]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
A
P
N
Q
A
L
L
R
I
L
K
E
T
E
F
K
K
I
K
V
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
I
-
P
E
G
E
K
V
K
I
P
V
A
I
K
E
L
R
E
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
L
T
S
--
T
V
Q
L
I
T
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
H
K
-
D
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
R
A
K
L
L
G
A
E
E
---------
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
S
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
D
E
R
M
H
L
------------
M
D
E
E
D
M
D
D
V
V
D
A
D
E
Y
L
I
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
PsiBlast_CBE
69.33
99%
-108
- C2 -
4RIW
1
D:
[11-307]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
V
E
P
L
T
P
S
G
E
A
P
N
Q
A
L
L
R
I
L
K
E
T
E
F
K
K
I
K
V
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
I
-
P
E
G
E
K
V
K
I
P
V
A
I
K
E
L
R
E
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
L
T
S
--
T
V
Q
L
I
T
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
H
K
-
D
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
A
K
L
L
G
A
E
E
K
E
Y
H
A
E
G
G
K
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
R
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
S
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
D
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
66
PsiBlast_CBE
69.31
100%
-103
- C2 -
4LI5
1
A:
[4-328]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
E
A
P
N
Q
A
L
L
R
I
L
K
E
T
E
F
K
K
I
K
V
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
I
-
P
E
G
E
K
V
K
I
P
V
A
I
K
E
L
R
E
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
L
T
S
--
T
V
Q
L
I
T
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
H
K
-
D
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
A
K
L
L
G
A
E
E
K
E
Y
H
A
E
G
G
K
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
S
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
D
E
----------------------
D
D
V
V
D
A
D
E
Y
L
I
P
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
69.25
99%
-117
- C2 -
4RIX
1
EGFR_HUMAN
B:
[11-307]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
V
E
P
L
T
P
S
G
E
A
P
N
Q
A
L
L
R
I
L
K
E
T
E
F
K
K
I
K
V
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
I
-
P
E
G
E
K
V
K
I
P
V
A
I
K
E
L
R
E
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
L
T
S
--
T
V
Q
L
I
T
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
H
K
-
D
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
A
K
L
L
G
A
E
E
K
E
Y
H
A
----
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
R
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
S
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
D
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
30
PsiBlast_CBE
69.14
100%
-106
- C2 -
4G5J
3
A:
[4-324]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
E
A
P
N
Q
A
L
L
R
I
L
K
E
T
E
F
K
K
I
K
V
L
G
S
----
T
V
Y
K
G
L
W
I
-
P
E
G
E
K
V
K
I
P
V
A
I
K
E
----------
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
L
T
S
--
T
V
Q
L
I
T
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
H
K
-
D
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
A
K
L
L
G
A
E
E
K
E
Y
H
A
E
G
G
K
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
S
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
D
E
R
M
H
L
P
S
P
T
D
S
N
F
Y
R
A
L
M
D
E
E
D
M
D
D
V
V
D
A
D
E
Y
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
69.14
100%
-108
- C2 -
3VJO
1
A:
[8-330]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
E
A
P
N
Q
A
L
L
R
I
L
K
E
T
E
F
K
K
I
K
V
L
G
S
--
F
G
T
V
Y
K
G
L
W
I
-
P
E
G
E
K
V
K
I
P
V
A
I
K
---
E
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
L
T
S
--
T
V
Q
L
I
T
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
H
K
-
D
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
A
K
L
L
G
A
E
E
K
E
Y
H
A
E
G
G
K
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
S
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
D
E
--------------------
D
M
D
D
V
V
D
A
D
E
Y
L
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
42
PsiBlast_CBE
69.09
99%
-108
- C2 -
4I24
1
B:
[7-321]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
Q
A
L
L
R
I
L
K
E
T
E
F
K
K
I
K
V
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
I
-
P
E
G
E
K
V
K
I
P
V
A
I
K
E
L
R
E
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
L
T
S
--
T
V
Q
L
I
M
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
H
K
-
D
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
A
K
L
L
G
-----------
K
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
S
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
D
E
R
M
H
L
P
S
P
T
D
S
N
F
Y
R
A
L
M
D
E
E
D
M
D
D
V
V
D
A
D
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
50
PsiBlast_CBE
68.98
99%
-108
- C2 -
2ITO
1
A:
[1-324]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
E
A
P
N
Q
A
L
L
R
I
L
K
E
T
E
F
K
K
I
K
V
L
S
S
G
A
F
G
T
V
Y
K
G
L
W
I
-
P
E
G
E
K
V
K
I
P
V
A
I
K
E
L
R
E
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
L
T
S
--
T
V
Q
L
I
T
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
H
K
-
D
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
A
K
L
L
G
A
E
E
---------
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
S
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
D
E
R
M
H
L
------------
M
D
E
E
D
M
D
D
V
V
D
A
D
E
Y
L
I
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
93
PsiBlast_CBE
68.85
99%
-122
- C2 -
3LZB
1
EGFR_HUMAN
A:
[8-288]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
R
I
L
K
E
T
E
F
K
K
I
K
V
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
I
-
P
E
G
E
K
V
K
I
P
V
A
I
K
E
L
R
E
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
L
T
S
--
T
V
Q
L
I
T
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
H
K
-
D
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
----------------
K
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
R
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
S
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
92
PsiBlast_CBE
68.57
99%
-119
- C2 -
3LZB
1
EGFR_HUMAN
B:
[8-288]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
R
I
L
K
E
T
E
F
K
K
I
K
V
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
I
-
P
E
G
E
K
V
K
I
P
V
A
I
K
E
L
R
E
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
L
T
S
--
T
V
Q
L
I
T
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
H
K
-
D
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
----------------
K
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
R
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
S
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
68.55
99%
-113
- C2 -
4RIY
1
EGFR_HUMAN
B:
[11-307]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
V
E
P
L
T
P
S
G
E
A
P
N
Q
A
L
L
R
I
L
K
E
T
E
F
K
K
I
K
V
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
I
-
P
E
G
E
K
V
K
I
P
V
A
I
K
E
L
R
E
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
L
T
S
--
T
V
Q
L
I
T
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
H
K
-
D
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
A
K
L
L
G
A
E
E
K
E
Y
H
A
----
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
R
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
S
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
D
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
65
PsiBlast_CBE
68.54
99%
-112
- C2 -
4HJO
1
A:
[18-299]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
R
I
L
K
E
T
E
F
K
K
I
K
V
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
I
-
P
----
V
K
I
P
V
A
I
K
E
L
R
E
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
L
T
S
--
T
V
Q
L
I
T
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
H
K
-
D
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
A
K
L
L
G
A
E
E
K
E
Y
H
A
E
G
G
K
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
R
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
S
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
D
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
68.36
99%
-111
- C2 -
4RIW
1
EGFR_HUMAN
B:
[11-307]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
V
E
P
L
T
P
S
G
E
A
P
N
Q
A
L
L
R
I
L
K
E
T
E
F
K
K
I
K
V
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
I
-
P
E
G
E
K
V
K
I
P
V
A
I
K
E
L
R
E
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
L
T
S
--
T
V
Q
L
I
T
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
H
K
-
D
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
A
K
L
L
G
A
E
E
K
E
Y
H
A
----
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
R
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
S
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
D
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
35
PsiBlast_CBE
68.22
100%
-102
- C2 -
2J6M
1
A:
[2-325]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
A
P
N
Q
A
L
L
R
I
L
K
E
T
E
F
K
K
I
K
V
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
I
-
P
E
G
E
K
V
K
I
P
V
A
I
K
E
L
R
E
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
L
T
S
--
T
V
Q
L
I
T
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
H
K
-
D
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
A
K
L
L
G
A
E
E
K
E
Y
H
A
E
G
G
K
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
S
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
D
------------------
D
E
E
D
M
D
D
V
V
D
A
D
E
Y
L
I
P
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
PsiBlast_CBE
68.04
99%
-105
- C2 -
4RIY
1
D:
[11-307]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
V
E
P
L
T
P
S
G
E
A
P
N
Q
A
L
L
R
I
L
K
E
T
E
F
K
K
I
K
V
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
I
-
P
E
G
E
K
V
K
I
P
V
A
I
K
E
L
R
E
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
L
T
S
--
T
V
Q
L
I
T
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
H
K
-
D
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
A
K
L
L
G
A
E
E
K
E
Y
H
A
E
G
G
K
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
R
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
S
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
D
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
48
PsiBlast_CBE
68.01
99%
-106
- C2 -
2ITQ
1
A:
[2-323]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
A
P
N
Q
A
L
L
R
I
L
K
E
T
E
F
K
K
I
K
V
L
S
S
G
A
F
G
T
V
Y
K
G
L
W
I
-
P
E
G
E
K
V
K
I
P
V
A
I
K
E
L
R
E
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
L
T
S
--
T
V
Q
L
I
T
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
H
K
-
D
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
A
K
L
L
G
A
E
E
K
E
Y
H
A
E
G
G
K
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
S
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
----------------------
D
M
D
D
V
V
D
A
D
E
Y
L
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
29
PsiBlast_CBE
67.88
99%
-106
- C2 -
4LL0
1
EGFR_HUMAN
A:
[6-326]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
A
P
N
Q
A
L
L
R
I
L
K
E
T
E
F
K
K
I
K
V
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
I
-
P
E
G
E
K
V
K
I
P
V
A
I
K
E
L
R
E
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
L
T
S
--
T
V
Q
L
I
M
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
H
K
-
D
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
R
A
K
L
L
-------------
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
S
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
D
E
R
M
----------------
E
E
D
M
D
-
V
V
D
A
D
E
Y
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
47
PsiBlast_CBE
67.81
99%
-106
- C2 -
3UG1
1
A:
[9-330]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
A
P
N
Q
A
L
L
R
I
L
K
E
T
E
F
K
K
I
K
V
L
S
S
---
G
T
V
Y
K
G
L
W
I
-
P
E
G
E
K
V
K
I
P
V
A
I
K
E
-----
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
L
T
S
--
T
V
Q
L
I
M
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
H
K
-
D
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
A
K
L
L
G
A
E
E
K
E
Y
H
A
E
G
G
K
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
S
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
D
------------------
D
E
E
D
M
D
D
V
V
D
A
D
E
Y
L
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
49
PsiBlast_CBE
67.54
99%
-106
- C2 -
2ITP
1
A:
[2-323]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
A
P
N
Q
A
L
L
R
I
L
K
E
T
E
F
K
K
I
K
V
L
S
S
G
A
F
G
T
V
Y
K
G
L
W
I
-
P
E
G
E
K
V
K
I
P
V
A
I
K
E
L
R
E
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
L
T
S
--
T
V
Q
L
I
T
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
H
K
-
D
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
A
K
L
L
G
A
E
E
K
E
Y
H
A
E
G
G
K
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
S
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
D
-----------------
M
D
E
E
D
M
D
D
V
V
D
A
D
E
Y
L
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
91
PsiBlast_CBE
67.49
99%
-116
- C2 -
3LZB
1
EGFR_HUMAN
C:
[9-288]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
R
I
L
K
E
T
E
F
K
K
I
K
V
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
I
-
P
E
G
E
K
V
K
I
P
V
A
I
K
E
L
R
E
A
-----
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
L
T
S
--
T
V
Q
L
I
T
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
H
K
-
D
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
----------------
K
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
R
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
S
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
90
PsiBlast_CBE
67.04
99%
-119
- C2 -
3LZB
1
EGFR_HUMAN
D:
[8-288]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
R
I
L
K
E
T
E
F
K
K
I
K
V
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
I
-
P
E
G
E
K
V
K
I
P
V
A
I
K
E
L
R
E
----
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
L
T
S
--
T
V
Q
L
I
T
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
H
K
-
D
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
----------------
K
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
R
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
S
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
104
PsiBlast_CBE
66.31
77%
-107
- C2 -
3BCE
2
C:
[2-289]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
A
P
N
Q
A
Q
L
R
I
L
K
E
T
E
L
K
R
V
K
V
L
G
S
G
A
F
G
T
V
Y
K
G
I
W
V
-
P
E
G
E
T
V
K
I
P
V
A
I
K
I
L
N
E
T
T
G
P
K
A
N
V
E
F
M
D
E
A
L
I
M
A
S
M
D
H
P
H
L
V
R
L
L
G
V
C
L
S
P
--
T
I
Q
L
V
T
Q
L
M
P
H
G
C
L
L
E
Y
V
H
E
H
K
-
D
N
I
G
S
Q
L
L
L
N
W
C
V
Q
I
A
K
G
M
M
Y
L
E
E
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
S
P
N
H
V
K
I
T
D
F
G
L
A
R
L
L
E
-
D
E
K
E
Y
N
A
D
G
-
K
M
P
I
K
W
M
A
L
E
C
I
H
Y
R
K
F
T
H
Q
S
D
V
W
S
Y
G
V
T
I
W
E
L
M
T
F
G
G
K
P
Y
D
G
I
P
T
R
E
I
P
D
L
L
E
K
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
V
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
K
E
L
A
A
E
F
S
R
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
D
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
103
PsiBlast_CBE
65.89
78%
-103
- C2 -
3PP0
1
ERBB2_HUMAN
A:
[5-292]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
P
N
Q
A
L
L
R
I
L
K
E
T
E
L
R
K
V
K
V
L
G
S
G
A
F
G
T
V
Y
K
G
I
W
I
-
P
D
G
E
N
V
K
I
P
V
A
I
K
V
L
R
E
N
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
G
V
G
S
P
Y
V
S
R
L
L
G
I
C
L
T
S
--
T
V
Q
L
V
T
Q
L
M
P
Y
G
C
L
L
D
H
V
R
E
N
R
-
G
R
L
G
S
Q
D
L
L
N
W
C
M
Q
I
A
K
G
M
S
Y
L
E
D
V
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
S
P
N
H
V
K
I
T
D
F
G
L
A
R
L
L
D
I
D
E
T
E
Y
H
A
--
G
K
V
P
I
K
W
M
A
L
E
S
I
L
R
R
R
F
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
A
K
P
Y
D
G
I
P
A
R
E
I
P
D
L
L
E
K
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
S
E
C
R
P
R
F
R
E
L
V
S
E
F
S
R
M
A
R
D
P
Q
R
F
V
V
I
Q
-
N
E
D
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
102
PsiBlast_CBE
65.03
78%
-99
- C2 -
3PP0
1
B:
[5-308]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
P
N
Q
A
L
L
R
I
L
K
E
T
E
L
R
K
V
K
V
L
G
S
G
A
F
G
T
V
Y
K
G
I
W
I
-
P
D
G
E
N
V
K
I
P
V
A
I
K
V
L
R
E
N
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
G
V
G
S
P
Y
V
S
R
L
L
G
I
C
L
T
S
--
T
V
Q
L
V
T
Q
L
M
P
Y
G
C
L
L
D
H
V
R
E
N
R
-
G
R
L
G
S
Q
D
L
L
N
W
C
M
Q
I
A
K
G
M
S
Y
L
E
D
V
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
S
P
N
H
V
K
I
T
D
F
G
L
A
R
L
L
D
I
D
E
T
E
Y
H
A
--
G
K
V
P
I
K
W
M
A
L
E
S
I
L
R
R
R
F
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
A
K
P
Y
D
G
I
P
A
R
E
I
P
D
L
L
E
K
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
S
E
C
R
P
R
F
R
E
L
V
S
E
F
S
R
M
A
R
D
P
Q
R
F
V
V
I
Q
-
N
E
------
P
L
D
S
T
F
Y
R
S
L
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
106
PsiBlast_CBE
64.74
77%
-115
* C2 *
3BBT
1
D:
[8-287]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
R
I
L
K
E
T
E
L
K
R
V
K
V
L
G
S
G
A
F
G
T
V
Y
K
G
I
W
V
-
P
--
E
T
V
K
I
P
V
A
I
K
I
L
N
E
---
P
K
A
N
V
E
F
M
D
E
A
L
I
M
A
S
M
D
H
P
H
L
V
R
L
L
G
V
C
L
S
P
--
T
I
Q
L
V
T
Q
L
M
P
H
G
C
L
L
E
Y
V
H
E
H
K
-
D
N
I
G
S
Q
L
L
L
N
W
C
V
Q
I
A
K
G
M
M
Y
L
E
E
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
S
P
N
H
V
K
I
T
D
F
G
L
A
R
----------------
P
I
K
W
M
A
L
E
C
I
H
Y
R
K
F
T
H
Q
S
D
V
W
S
Y
G
V
T
I
W
E
L
M
T
F
G
G
K
P
Y
D
G
I
P
T
R
E
I
P
D
L
L
E
K
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
V
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
K
E
L
A
A
E
F
S
R
M
A
R
D
P
Q
R
Y
L
V
I
Q
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
100
PsiBlast_CBE
62.92
78%
-104
- C2 -
3RCD
1
ERBB2_HUMAN
C:
[9-321]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
L
L
R
I
L
K
E
T
E
L
R
K
V
K
V
L
G
S
G
A
F
G
T
V
Y
K
G
I
W
I
-
P
D
G
E
N
V
K
I
P
V
A
I
K
V
L
R
----
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
G
V
G
S
P
Y
V
S
R
L
L
G
I
C
L
T
S
--
T
V
Q
L
V
T
Q
L
M
P
Y
G
C
L
L
D
H
V
R
E
N
R
-
G
R
L
G
S
Q
D
L
L
N
W
C
M
Q
I
A
K
G
M
S
Y
L
E
D
V
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
S
P
N
H
V
K
I
T
D
F
G
L
-----------------
V
P
I
K
W
M
A
L
E
S
I
L
R
R
R
F
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
A
K
P
Y
D
G
I
P
A
R
E
I
P
D
L
L
E
K
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
S
E
C
R
P
R
F
R
E
L
V
S
E
F
S
R
M
A
R
D
P
Q
R
F
V
V
I
Q
-
N
--------
L
D
S
T
F
Y
R
S
L
L
E
D
D
---
D
L
V
D
A
E
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
101
PsiBlast_CBE
62.00
78%
-104
- C2 -
3RCD
1
ERBB2_HUMAN
A:
[9-321]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
L
L
R
I
L
K
E
T
E
L
R
K
V
K
V
L
G
S
G
A
F
G
T
V
Y
K
G
I
W
I
-
P
D
G
E
N
V
K
I
P
V
A
I
K
V
L
R
----
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
G
V
G
S
P
Y
V
S
R
L
L
G
I
C
L
T
S
--
T
V
Q
L
V
T
Q
L
M
P
Y
G
C
L
L
D
H
V
R
E
N
R
-
G
R
L
G
S
Q
D
L
L
N
W
C
M
Q
I
A
K
G
M
S
Y
L
E
D
V
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
S
P
N
H
V
K
I
T
D
F
G
L
-----------------
V
P
I
K
W
M
A
L
E
S
I
L
R
R
R
F
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
A
K
P
Y
D
G
I
P
A
R
E
I
P
D
L
L
E
K
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
S
E
C
R
P
R
F
R
E
L
V
S
E
F
S
R
M
A
R
D
P
Q
R
F
V
V
I
Q
-
N
--------
L
D
S
T
F
Y
R
S
L
L
E
D
D
---
D
L
V
D
A
E
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
108
Fugue
50.73
35%
-90
- C2 -
1BYG
1
CSK_HUMAN
A:
[15-276]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
W
A
L
N
M
K
E
L
K
L
L
Q
T
I
G
K
G
E
F
G
D
V
M
L
G
D
Y
R
G-------
N
K
V
A
V
K
C
I
K
-----
N
D
A
Q
A
F
L
A
E
A
S
V
M
T
Q
L
R
H
S
N
L
V
Q
L
L
G
V
I
V
--EE
G
L
Y
I
V
T
E
Y
M
A
K
G
S
L
V
D
Y
L
R
S
R
G
R
S
V
L
G
G
D
C
L
L
K
F
S
L
D
V
C
E
A
M
E
Y
L
E
G
N
N
F
V
H
R
D
L
A
A
R
N
V
L
V
S
E
D
N
V
A
K
V
S
D
F
G
-----------------
L
L
P
V
K
W
T
A
P
E
A
L
R
E
K
K
F
S
T
K
S
D
V
W
S
F
G
I
L
L
W
E
I
Y
S
F
G
R
V
P
Y
P
R
I
P
L
K
D
V
V
P
R
V
E
K
G
Y
K
M
D
A
P
D
G
C
P
P
A
V
Y
E
V
M
K
N
C
W
H
L
D
A
A
M
R
P
S
F
L
Q
L
R
E
Q
L
E
H
I
K
T
H
E
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------