@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : EPHA2_HUMAN: (2015-10-07 )
MELQAARACFALLWGCALAAAAAAQGKEVVLLDFAAAGGELGWLTHPYGKGWDLMQNIMNDMPIYMYSVCNVMSGDQDNWLRTNWVYRGEAERIFIELKFTVRDCNSFPGGASSCKETFNLYYAESDLDYGTNFQKRLFTKIDTIAPDEITVSSDFEARHVKLNVEERSVGPLTRKGFYLAFQDIGACVALLSVRVYYKKCPELLQGLAHFPETIAGSDAPSLATVAGTCVDHAVVPPGGEEPRMHCAVDGEWLVPIGQCLCQAGYEKVEDACQACSPGFFKFEASESPCLECPEHTLPSPEGATSCECEEGFFRAPQDPASMPCTRPPSAPHYLTAVGMGAKVELRWTPPQDSGGREDIVYSVTCEQCWPESGECGPCEASVRYSEPPHGLTRTSVTVSDLEPHMNYTFTVEARNGVSGLVTSRSFRTASVSINQTEPPKVRLEGRSTTSLSVSWSIPPPQQSRVWKYEVTYRKKGDSNSYNVRRTEGFSVTLDDLAPDTTYLVQVQALTQEGQGAGSKVHEFQTLSPEGSGNLAVIGGVAVGVVLLLVLAGVGFFIHRRRKNQRARQSPEDVYFSKSEQLKPLKTYVDPHTYEDPNQAVLKFTTEIHPSCVTRQKVIGAGEFGEVYKGMLKTSSGKKEVPVAIKTLKAGYTEKQRVDFLGEAGIMGQFSHHNIIRLEGVISKYKPMMIITEYMENGALDKFLREKDGEFSVLQLVGMLRGIAAGMKYLANMNYVHRDLAARNILVNSNLVCKVSDFGLSRVLEDDPEATYTTSGGKIPIRWTAPEAISYRKFTSASDVWSFGIVMWEVMTYGERPYWELSNHEVMKAINDGFRLPTPMDCPSAIYQLMMQCWQQERARRPKFADIVSILDKLIRAPDSLKTLADFDPRVSIRLPSTSGSEGVPFRTVSEWLESIKMQQYTEHFMAAGYTAIEKVVQMTNDDIKRIGVRLPGHQKRIAYSLLGLKDQVNTVGIPI
Atome Classification :
(88 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570......-.580.......590.......600.......610....-.-..620.......630......-.-640.......650-.......660.......670.......680.......690.......700......-.710..-.-....720.......730.......740.......750.......760....---...770.-.-...--..780.......790.......800.......810.......820.......830.......840.......850.......860.......870.......880.......890.......900.......910.......920.......930.......940.......950.......960.......970....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
ME
L
Q
A
A
R
A
C
F
A
L
L
W
G
C
A
L
A
A
A
A
AAQG
K
E
V
V
L
L
D
FAAAGGELGWLTHPYGK
G
W
D
L
M
Q
N
I
M
NDM
P
I
Y
M
Y
S
V
C
N
VMSGDQDN
W
L
R
T
N
W
V
YRGEA
E
R
I
F
I
E
L
K
F
T
V
RDCNSFPGG
A
S
S
C
K
E
T
F
N
L
Y
Y
AESDLDYGT
N
F
Q
K
R
L
F
T
K
IDTIAPD
E
I
T
VSSDFE
A
R
H
V
K
L
N
V
EERSVGPLTRK
G
F
Y
L
A
F
Q
D
I
G
A
C
V
A
L
L
S
V
R
V
Y
Y
K
K
C
P
E
L
L
Q
G
L
A
HF
P
E
T
IAGSDAP
S
L
A
T
V
A
G
T
CVDHAVVPPGGEEP
R
M
H
C
A
VDG
E
W
L
V
P
I
G
Q
C
L
C
Q
A
G
Y
E
K
V
E
D
A
C
Q
ACSPG
F
F
K
FEASESPCLECPEHTLPSPEGATSCECEEGFFRAPQDPASMPCTRPPSAP
H
Y
L
T
A
VGMG
A
K
V
E
L
R
WTPPQDSGGRE
D
I
V
Y
S
V
T
C
E
QCWPESGECGPCEASVRYSEPPHG
L
T
R
T
S
V
T
V
S
DLEPHM
N
Y
T
F
T
V
EARNGVS
G
L
V
TSR
S
F
R
T
A
S
V
S
INQTEP
P
K
V
R
L
EGRS
T
T
S
L
S
V
S
WSIPPPQQS
R
V
W
K
Y
E
V
T
Y
R
KKGDSNS
Y
N
V
R
RTEG
F
S
V
T
L
D
DLAPD
T
T
Y
L
V
Q
V
Q
A
L
T
QEGQGAGSK
V
H
E
F
Q
TLSPEGSG
N
L
A
V
I
G
G
V
A
V
G
V
V
L
L
L
V
L
A
G
V
G
F
F
I
H
R
R
RK
N
Q
RARQSPEDVYFSK-SEQL
K
P
L
K
T
YVDPHTYEDP
N
Q
A
V
L
K
F
TTEI
H
P
S
C
V
T
R
Q
-
K
-VIGA
G
E
F
G
E
V
Y
K
G
M
L
KTSSGK-K-EV
P
V
A
I
K
T
L
KAGY-
T
E
K
Q
R
V
D
F
LGEAGIMGQFSHH
N
I
I
R
L
E
G
V
I
S
KYK
P
M
M
I
I
T
E
Y
M
ENG
A
L
D
K
F
L
R
EKD-G
E
F
S
V
L
-
Q
-
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
AN
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
VNS
N
L
V
C
K
VSDF
G
L
S
R
V
LED---DPE
A
T
Y
T-T-SG
G
--
K
I
P
I
R
WTAPEAI
S
Y
RKFTSA
S
D
V
W
S
F
G
I
V
M
W
E
V
M
TYGERP
Y
W
ELS
N
H
E
V
M
K
A
I
NDGFRLPTPMD
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
RARRP
K
F
A
D
I
V
S
I
L
D
K
L
IRAPD
S
L
K
T
L
ADFDP
R
V
S
I
R
LPSTSGSEGV
P
F
R
T
V
S
E
W
L
E
S
I
K
M
Q
Q
Y
T
E
H
F
M
AA
G
Y
T
A
I
E
K
V
V
Q
M
T
N
D
D
I
K
R
I
GVRLPG
H
Q
K
R
I
A
Y
S
L
LGLKDQVNTVGIPI
22
PsiBlast_CBE
76.72
100%
-115
- C2 -
1MQB
1
B:
[35-316]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
F
T
T
E
I
H
P
S
C
V
T
R
Q
-
K
-
V
I
G
A
G
E
F
G
E
V
Y
K
G
M
L
K
T
-----
K
-
E
V
P
V
A
I
K
T
L
K
A
G
Y
-
T
E
K
Q
R
V
D
F
L
G
E
A
G
I
M
G
Q
F
S
H
H
N
I
I
R
L
E
G
V
I
S
K
Y
K
P
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
E
K
D
-
G
E
F
S
V
L
-
Q
-
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
S
R
V
L
--------------------
K
I
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
L
S
N
H
E
V
M
K
A
I
N
D
G
F
R
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
S
I
L
D
K
L
I
R
A
P
D
S
L
K
T
---------------------------------------------------------------------------------------------
5
PsiBlast_PDB
75.84
100%
-115
- C2 -
1MQB
1
EPHA2_HUMAN
A:
[38-320]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
T
E
I
H
P
S
C
V
T
R
Q
-
K
-
V
I
G
A
G
E
F
G
E
V
Y
K
G
M
L
K
T
---
K
-
K
-
E
V
P
V
A
I
K
T
L
K
A
G
Y
-
T
E
K
Q
R
V
D
F
L
G
E
A
G
I
M
G
Q
F
S
H
H
N
I
I
R
L
E
G
V
I
S
K
Y
K
P
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
E
K
D
-
G
E
F
S
V
L
-
Q
-
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
------------------------
K
I
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
L
S
N
H
E
V
M
K
A
I
N
D
G
F
R
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
S
I
L
D
K
L
I
R
A
P
D
S
L
K
T
L
A
D
F
-----------------------------------------------------------------------------------------
119
HHSearch
75.47
97%
-115
- C2 -
1MQB
1
EPHA2_HUMAN
A:
[38-320]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
T
E
I
H
P
S
C
V
T
R
Q
-
K
-
V
I
G
A
G
E
F
G
E
V
Y
K
G
M
L
K
T
---
K
-
K
-
E
V
P
V
A
I
K
T
L
K
A
G
Y
-
T
E
K
Q
R
V
D
F
L
G
E
A
G
I
M
G
Q
F
S
H
H
N
I
I
R
L
E
G
V
I
S
K
Y
K
P
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
E
K
D
-
G
E
F
S
V
L
-
Q
-
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
------------------------
K
I
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
L
S
N
H
E
V
M
K
A
I
N
D
G
F
R
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
S
I
L
D
K
L
I
R
A
P
D
S
L
K
T
L
A
D
F
-----------------------------------------------------------------------------------------
44
PsiBlast_CBE
73.77
74%
-118
- C2 -
2XYU
7
A:
[1-278]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
A
K
E
I
D
A
S
C
I
K
I
E
-
K
-
V
I
G
V
G
E
F
G
E
V
C
S
G
R
L
K
V
P
-
G
K
-
R
-
E
I
C
V
A
I
K
T
L
K
A
G
Y
-
T
D
K
Q
R
R
D
F
L
S
E
A
S
I
M
G
Q
F
D
H
P
N
I
I
H
L
E
G
V
V
T
K
C
K
P
V
M
I
I
T
E
Y
M
E
N
G
S
L
D
A
F
L
R
K
N
D
-
G
R
F
T
V
I
-
Q
-
L
V
G
M
L
R
G
I
G
S
G
M
K
Y
L
S
D
M
S
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
---------------------------
I
P
I
R
W
T
A
P
E
A
I
A
Y
R
K
F
T
S
A
S
D
V
W
S
Y
G
I
V
M
W
E
V
M
S
Y
G
E
R
P
Y
W
D
M
S
N
Q
D
V
I
K
A
I
E
E
G
Y
R
L
P
P
P
M
D
C
P
I
A
L
H
Q
L
M
L
D
C
W
Q
K
E
R
S
D
R
P
K
F
G
Q
I
V
N
M
L
D
K
L
I
R
N
P
N
S
L
K
R
T
--------------------------------------------------------------------------------------------
10
PsiBlast_PDB
73.40
65%
-109
- C2 -
3FXX
1
A:
[30-328]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
Q
T
V
H
E
F
A
K
E
L
D
A
T
N
I
S
I
D
-
K
-
V
V
G
A
G
E
F
G
E
V
C
S
G
R
L
K
L
P
S
-
K
-
K
-
E
I
S
V
A
I
K
T
L
K
V
G
Y
-
T
E
K
Q
R
R
D
F
L
G
E
A
S
I
M
G
Q
F
D
H
P
N
I
I
R
L
E
G
V
V
T
K
S
K
P
V
M
I
V
T
E
Y
M
E
N
G
S
L
D
S
F
L
R
K
H
D
-
A
Q
F
T
V
I
-
Q
-
L
V
G
M
L
R
G
I
A
S
G
M
K
Y
L
S
D
M
G
Y
V
H
R
D
L
A
A
R
N
I
L
I
N
S
N
L
V
C
K
V
S
D
F
G
L
S
R
V
L
E
D
---
D
-----------
G
--
K
I
P
I
R
W
T
S
P
E
A
I
A
Y
R
K
F
T
S
A
S
D
V
W
S
Y
G
I
V
L
W
E
V
M
S
Y
G
E
R
P
Y
W
E
M
S
N
Q
D
V
I
K
A
V
D
E
G
Y
R
L
P
P
P
M
D
C
P
A
A
L
Y
Q
L
M
L
D
C
W
Q
K
D
R
N
N
R
P
K
F
E
Q
I
V
S
I
L
D
K
L
I
R
N
P
G
S
L
K
I
I
T
--
A
A
R
P
S
N
L
L
L
D
-------------------------------------------------------------------------------
16
PsiBlast_PDB
73.29
65%
-108
- C2 -
2QOQ
1
A:
[21-332]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
Y
V
D
P
H
--
E
D
P
T
Q
T
V
H
E
F
A
K
E
L
D
A
T
N
I
S
I
D
-
K
-
V
V
G
A
G
E
F
G
E
V
C
S
G
R
L
K
L
P
S
-
K
-
K
-
E
I
S
V
A
I
K
T
L
K
V
G
Y
-
T
E
K
Q
R
R
D
F
L
G
E
A
S
I
M
G
Q
F
D
H
P
N
I
I
R
L
E
G
V
V
T
K
S
K
P
V
M
I
V
T
E
Y
M
E
N
G
S
L
D
S
F
L
R
K
H
D
-
A
Q
F
T
V
I
-
Q
-
L
V
G
M
L
R
G
I
A
S
G
M
K
Y
L
S
D
M
G
Y
V
H
R
D
L
A
A
R
N
I
L
I
N
S
N
L
V
C
K
V
S
D
F
-----------------------
G
--
K
I
P
I
R
W
T
S
P
E
A
I
A
Y
R
K
F
T
S
A
S
D
V
W
S
Y
G
I
V
L
W
E
V
M
S
Y
G
E
R
P
Y
W
E
M
S
N
Q
D
V
I
K
A
V
D
E
G
Y
R
L
P
P
P
M
D
C
P
A
A
L
Y
Q
L
M
L
D
C
W
Q
K
D
R
N
N
R
P
K
F
E
Q
I
V
S
I
L
D
K
L
I
R
N
P
G
S
L
K
I
I
T
-------
N
L
L
L
D
Q
S
-----------------------------------------------------------------------------
20
PsiBlast_PDB
72.75
64%
-110
- C2 -
2QOC
2
A:
[10-303]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
K
E
L
D
A
T
N
I
S
I
D
-
K
-
V
V
G
A
G
E
F
G
E
V
C
S
G
R
L
K
L
P
S
-
K
-
K
-
E
I
S
V
A
I
K
T
L
K
V
G
Y
-
T
E
K
Q
R
R
D
F
L
G
E
A
S
I
M
G
Q
F
D
H
P
N
I
I
R
L
E
G
V
V
T
K
S
K
P
V
M
I
V
T
E
Y
M
E
N
G
S
L
D
S
F
L
R
K
H
D
-
A
Q
F
T
V
I
-
Q
-
L
V
G
M
L
R
G
I
A
S
G
M
K
Y
L
S
D
M
G
Y
V
H
R
D
L
A
A
R
N
I
L
I
N
S
N
L
V
C
K
V
S
D
F
G
L
S
R
V
L
E
D
------------------
K
I
P
I
R
W
T
S
P
E
A
I
A
Y
R
K
F
T
S
A
S
D
V
W
S
Y
G
I
V
L
W
E
V
M
S
Y
G
E
R
P
Y
W
E
M
S
N
Q
D
V
I
K
A
V
D
E
G
Y
R
L
P
P
P
M
D
C
P
A
A
L
Y
Q
L
M
L
D
C
W
Q
K
D
R
N
N
R
P
K
F
E
Q
I
V
S
I
L
D
K
L
I
R
N
P
G
S
L
K
I
I
T
S
A
A
A
R
P
S
N
L
L
L
D
Q
S
-----------------------------------------------------------------------------
57
PsiBlast_CBE
72.71
67%
-107
- C2 -
2VWZ
1
A:
[11-291]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
E
I
D
V
S
Y
V
K
I
E
-
E
-
V
I
G
A
G
E
F
G
E
V
C
R
G
R
L
K
-
A
P
G
K
-
K
-
E
S
C
V
A
I
K
T
L
K
G
G
Y
-
T
E
R
Q
R
R
E
F
L
S
E
A
S
I
M
G
Q
F
E
H
P
N
I
I
R
L
E
G
V
V
T
N
S
M
P
V
M
I
L
T
E
F
M
E
N
G
A
L
D
S
F
L
R
L
N
D
-
G
Q
F
T
V
I
-
Q
-
L
V
G
M
L
R
G
I
A
S
G
M
R
Y
L
A
E
M
S
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
S
R
F
L
E
E
NSS
D
----------
G
G
--
K
I
P
I
R
W
T
A
P
E
A
I
A
F
R
K
F
T
S
A
S
D
A
W
S
Y
G
I
V
M
W
E
V
M
S
F
G
E
R
P
Y
W
D
M
S
N
Q
D
V
I
N
A
I
E
Q
D
Y
R
L
P
P
P
P
D
C
P
T
S
L
H
Q
L
M
L
D
C
W
Q
K
D
R
N
A
R
P
R
F
P
Q
V
V
S
A
L
D
K
M
I
R
N
P
A
S
L
K
I
V
A
-------------------------------------------------------------------------------------------
35
PsiBlast_CBE
72.65
70%
-108
- C2 -
1JPA
1
EPHB2_MOUSE
A:
[8-306]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
I
F
I
D
P
F
T
F
E
D
P
N
E
A
V
R
E
F
A
K
E
I
D
I
S
C
V
K
I
E
-
Q
-
V
I
G
A
G
E
F
G
E
V
C
S
G
H
L
K
L
-----
R
-
E
I
F
V
A
I
K
T
L
K
S
G
Y
-
T
E
K
Q
R
R
D
F
L
S
E
A
S
I
M
G
Q
F
D
H
P
N
V
I
H
L
E
G
V
V
T
K
S
T
P
V
M
I
I
T
E
F
M
E
N
G
S
L
D
S
F
L
R
Q
N
D
-
G
Q
F
T
V
I
-
Q
-
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
D
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
----------------------------
P
I
R
W
T
A
P
E
A
I
Q
Y
R
K
F
T
S
A
S
D
V
W
S
Y
G
I
V
M
W
E
V
M
S
Y
G
E
R
P
Y
W
D
M
T
N
Q
D
V
I
N
A
I
E
Q
D
Y
R
L
P
P
P
M
D
C
P
S
A
L
H
Q
L
M
L
D
C
W
Q
K
D
R
N
H
R
P
K
F
G
Q
I
V
N
T
L
D
K
M
I
R
N
P
N
S
L
K
A
---------------------------------------------------------------------------------------------
58
PsiBlast_CBE
72.51
67%
-108
- C2 -
2VWY
1
A:
[11-291]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
E
I
D
V
S
Y
V
K
I
E
-
E
-
V
I
G
A
G
E
F
G
E
V
C
R
G
R
L
K
-
A
P
G
K
-
K
-
E
S
C
V
A
I
K
T
L
K
G
G
Y
-
T
E
R
Q
R
R
E
F
L
S
E
A
S
I
M
G
Q
F
E
H
P
N
I
I
R
L
E
G
V
V
T
N
S
M
P
V
M
I
L
T
E
F
M
E
N
G
A
L
D
S
F
L
R
L
N
D
-
G
Q
F
T
V
I
-
Q
-
L
V
G
M
L
R
G
I
A
S
G
M
R
Y
L
A
E
M
S
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
S
R
F
L
E
E
NSS
D
----------
G
G
--
K
I
P
I
R
W
T
A
P
E
A
I
A
F
R
K
F
T
S
A
S
D
A
W
S
Y
G
I
V
M
W
E
V
M
S
F
G
E
R
P
Y
W
D
M
S
N
Q
D
V
I
N
A
I
E
Q
D
Y
R
L
P
P
P
P
D
C
P
T
S
L
H
Q
L
M
L
D
C
W
Q
K
D
R
N
A
R
P
R
F
P
Q
V
V
S
A
L
D
K
M
I
R
N
P
A
S
L
K
I
V
A
-------------------------------------------------------------------------------------------
56
PsiBlast_CBE
72.48
67%
-110
- C2 -
2VX0
1
A:
[11-291]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
E
I
D
V
S
Y
V
K
I
E
-
E
-
V
I
G
A
G
E
F
G
E
V
C
R
G
R
L
K
-
A
P
G
K
-
K
-
E
S
C
V
A
I
K
T
L
K
G
G
Y
-
T
E
R
Q
R
R
E
F
L
S
E
A
S
I
M
G
Q
F
E
H
P
N
I
I
R
L
E
G
V
V
T
N
S
M
P
V
M
I
L
T
E
F
M
E
N
G
A
L
D
S
F
L
R
L
N
D
-
G
Q
F
T
V
I
-
Q
-
L
V
G
M
L
R
G
I
A
S
G
M
R
Y
L
A
E
M
S
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
S
R
F
L
E
E
NSS
D
-----------
G
--
K
I
P
I
R
W
T
A
P
E
A
I
A
F
R
K
F
T
S
A
S
D
A
W
S
Y
G
I
V
M
W
E
V
M
S
F
G
E
R
P
Y
W
D
M
S
N
Q
D
V
I
N
A
I
E
Q
D
Y
R
L
P
P
P
P
D
C
P
T
S
L
H
Q
L
M
L
D
C
W
Q
K
D
R
N
A
R
P
R
F
P
Q
V
V
S
A
L
D
K
M
I
R
N
P
A
S
L
K
I
V
A
-------------------------------------------------------------------------------------------
54
PsiBlast_CBE
72.33
67%
-110
- C2 -
2X9F
1
A:
[11-291]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
E
I
D
V
S
Y
V
K
I
E
-
E
-
V
I
G
A
G
E
F
G
E
V
C
R
G
R
L
K
-
A
P
G
K
-
K
-
E
S
C
V
A
I
K
T
L
---
Y
-
T
E
R
Q
R
R
E
F
L
S
E
A
S
I
M
G
Q
F
E
H
P
N
I
I
R
L
E
G
V
V
T
N
S
M
P
V
M
I
L
T
E
F
M
E
N
G
A
L
D
S
F
L
R
L
N
D
-
G
Q
F
T
V
I
-
Q
-
L
V
G
M
L
R
G
I
A
S
G
M
R
Y
L
A
E
M
S
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
S
R
F
L
----------------
G
G
--
K
I
P
I
R
W
T
A
P
E
A
I
A
F
R
K
F
T
S
A
S
D
A
W
S
Y
G
I
V
M
W
E
V
M
S
F
G
E
R
P
Y
W
D
M
S
N
Q
D
V
I
N
A
I
E
Q
D
Y
R
L
P
P
P
P
D
C
P
T
S
L
H
Q
L
M
L
D
C
W
Q
K
D
R
N
A
R
P
R
F
P
Q
V
V
S
A
L
D
K
M
I
R
N
P
A
S
L
K
I
V
A
-------------------------------------------------------------------------------------------
37
PsiBlast_CBE
72.32
74%
-115
- C2 -
2Y6M
3
A:
[4-284]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
R
E
F
A
K
E
I
D
A
S
C
I
K
I
E
-
K
-
V
I
G
V
G
E
F
G
E
V
C
S
G
R
L
K
V
P
-
G
K
-
R
-
E
I
C
V
A
I
K
T
L
K
A
G
Y
-
T
D
K
Q
R
R
D
F
L
S
E
A
S
I
M
G
Q
F
D
H
P
N
I
I
H
L
E
G
V
V
T
K
C
K
P
V
M
I
I
T
E
Y
M
E
N
G
S
L
D
A
F
L
R
K
N
D
-
G
R
F
T
V
I
-
Q
-
L
V
G
M
L
R
G
I
G
S
G
M
K
Y
L
S
D
M
S
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
----------------------------
P
I
R
W
T
A
P
E
A
I
A
Y
R
K
F
T
S
A
S
D
V
W
S
Y
G
I
V
M
W
E
V
M
S
Y
G
E
R
P
Y
W
D
M
S
N
Q
D
V
I
K
A
I
E
E
G
Y
R
L
P
P
P
M
D
C
P
I
A
L
H
Q
L
M
L
D
C
W
Q
K
E
R
S
D
R
P
K
F
G
Q
I
V
N
M
L
D
K
L
I
R
N
P
N
S
L
K
R
T
--------------------------------------------------------------------------------------------
36
PsiBlast_CBE
72.30
74%
-117
- C2 -
2Y6O
1
A:
[4-284]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
R
E
F
A
K
E
I
D
A
S
C
I
K
I
E
-
K
-
V
I
G
V
G
E
F
G
E
V
C
S
G
R
L
K
V
P
-
G
K
-
R
-
E
I
C
V
A
I
K
T
L
K
A
G
Y
-
T
D
K
Q
R
R
D
F
L
S
E
A
S
I
M
G
Q
F
D
H
P
N
I
I
H
L
E
G
V
V
T
K
C
K
P
V
M
I
I
T
E
Y
M
E
N
G
S
L
D
A
F
L
R
K
N
D
-
G
R
F
T
V
I
-
Q
-
L
V
G
M
L
R
G
I
G
S
G
M
K
Y
L
S
D
M
S
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
---------------------------
I
P
I
R
W
T
A
P
E
A
I
A
Y
R
K
F
T
S
A
S
D
V
W
S
Y
G
I
V
M
W
E
V
M
S
Y
G
E
R
P
Y
W
D
M
S
N
Q
D
V
I
K
A
I
E
E
G
Y
R
L
P
P
P
M
D
C
P
I
A
L
H
Q
L
M
L
D
C
W
Q
K
E
R
S
D
R
P
K
F
G
Q
I
V
N
M
L
D
K
L
I
R
N
P
N
S
L
K
R
T
--------------------------------------------------------------------------------------------
34
PsiBlast_CBE
72.15
70%
-110
- C2 -
1JPA
1
B:
[8-305]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
I
F
I
D
P
F
T
F
E
D
P
N
E
A
V
R
E
F
A
K
E
I
D
I
S
C
V
K
I
E
-
Q
-
V
I
G
A
G
E
F
G
E
V
C
S
G
H
L
K
------
R
-
E
I
F
V
A
I
K
T
L
K
S
G
Y
-
T
E
K
Q
R
R
D
F
L
S
E
A
S
I
M
G
Q
F
D
H
P
N
V
I
H
L
E
G
V
V
T
K
S
-
P
V
M
I
I
T
E
F
M
E
N
G
S
L
D
S
F
L
R
Q
N
D
-
G
Q
F
T
V
I
-
Q
-
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
D
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
----------------------------
P
I
R
W
T
A
P
E
A
I
Q
Y
R
K
F
T
S
A
S
D
V
W
S
Y
G
I
V
M
W
E
V
M
S
Y
G
E
R
P
Y
W
D
M
T
N
-
D
V
I
N
A
I
E
Q
D
Y
R
L
P
P
P
M
D
C
P
S
A
L
H
Q
L
M
L
D
C
W
Q
K
D
R
N
H
R
P
K
F
G
Q
I
V
N
T
L
D
K
M
I
R
N
P
N
S
L
K
----------------------------------------------------------------------------------------------
52
PsiBlast_CBE
72.07
67%
-112
- C2 -
4BB4
1
A:
[9-291]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
A
K
E
I
D
V
S
Y
V
K
I
E
-
E
-
V
I
G
A
G
E
F
G
E
V
C
R
G
R
L
K
-
A
P
G
K
-
K
-
E
S
C
V
A
I
K
T
L
---
Y
-
T
E
R
Q
R
R
E
F
L
S
E
A
S
I
M
G
Q
F
E
H
P
N
I
I
R
L
E
G
V
V
T
N
S
M
P
V
M
I
L
T
E
F
M
E
N
G
A
L
D
S
F
L
R
L
N
D
-
G
Q
F
T
V
I
-
Q
-
L
V
G
M
L
R
G
I
A
S
G
M
R
Y
L
A
E
M
S
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
S
R
F
------------------
G
--
K
I
P
I
R
W
T
A
P
E
A
I
A
F
R
K
F
T
S
A
S
D
A
W
S
Y
G
I
V
M
W
E
V
M
S
F
G
E
R
P
Y
W
D
M
S
N
Q
D
V
I
N
A
I
E
Q
D
Y
R
L
P
P
P
P
D
C
P
T
S
L
H
Q
L
M
L
D
C
W
Q
K
D
R
N
A
R
P
R
F
P
Q
V
V
S
A
L
D
K
M
I
R
N
P
A
S
L
K
I
V
A
-------------------------------------------------------------------------------------------
9
PsiBlast_PDB
72.07
65%
-110
- C2 -
2QO9
1
A:
[34-330]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
V
H
E
F
A
K
E
L
D
A
T
N
I
S
I
D
-
K
-
V
V
G
A
G
E
F
G
E
V
C
S
G
R
L
K
L
P
S
-
K
-
K
-
E
I
S
V
A
I
K
T
L
K
V
G
Y
-
T
E
K
Q
R
R
D
F
L
G
E
A
S
I
M
G
Q
F
D
H
P
N
I
I
R
L
E
G
V
V
T
K
S
K
P
V
M
I
V
T
E
Y
M
E
N
G
S
L
D
S
F
L
R
K
H
D
-
A
Q
F
T
V
I
-
Q
-
L
V
G
M
L
R
G
I
A
S
G
M
K
Y
L
S
D
M
G
Y
V
H
R
D
L
A
A
R
N
I
L
I
N
S
N
L
V
C
K
V
S
D
F
G
L
S
R
V
L
--------------------
K
I
P
I
R
W
T
S
P
E
A
I
A
Y
R
K
F
T
S
A
S
D
V
W
S
Y
G
I
V
L
W
E
V
M
S
Y
G
E
R
P
Y
W
E
M
S
N
Q
D
V
I
K
A
V
D
E
G
Y
R
L
P
P
P
M
D
C
P
A
A
L
Y
Q
L
M
L
D
C
W
Q
K
D
R
N
N
R
P
K
F
E
Q
I
V
S
I
L
D
K
L
I
R
N
P
G
S
L
K
I
I
T
-------
N
L
L
L
D
-------------------------------------------------------------------------------
55
PsiBlast_CBE
72.03
67%
-111
- C2 -
2VX1
1
A:
[11-291]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
E
I
D
V
S
Y
V
K
I
E
-
E
-
V
I
G
A
G
E
F
G
E
V
C
R
G
R
L
K
-
A
P
G
K
-
K
-
E
S
C
V
A
I
K
T
L
K
G
G
Y
-
T
E
R
Q
R
R
E
F
L
S
E
A
S
I
M
G
Q
F
E
H
P
N
I
I
R
L
E
G
V
V
T
N
S
M
P
V
M
I
L
T
E
F
M
E
N
G
A
L
D
S
F
L
R
L
N
D
-
G
Q
F
T
V
I
-
Q
-
L
V
G
M
L
R
G
I
A
S
G
M
R
Y
L
A
E
M
S
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
S
R
F
L
E
E
NSS
D
----------
G
G
--
K
I
P
I
R
W
T
A
P
E
A
I
A
F
R
K
F
T
S
A
S
D
A
W
S
Y
G
I
V
M
W
E
V
M
S
F
G
E
R
P
Y
W
D
M
S
N
Q
D
V
I
N
A
I
E
Q
D
Y
R
L
P
P
P
P
D
C
P
T
S
L
H
Q
L
M
L
D
C
W
Q
K
D
R
N
A
R
P
R
F
P
Q
V
V
S
A
L
D
K
M
I
R
N
P
A
S
L
K
I
V
A
-------------------------------------------------------------------------------------------
31
PsiBlast_CBE
72.03
69%
-107
- C2 -
3DKO
1
A:
[19-311]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
Y
I
D
P
E
T
Y
E
D
P
N
R
A
V
H
Q
F
A
K
E
L
D
A
S
C
I
K
I
E
-
R
-
V
I
G
A
-
E
F
G
E
V
C
S
G
R
L
K
L
P
-
G
K
-
R
-
D
V
A
V
A
I
K
T
L
K
V
G
Y
-
T
E
K
Q
R
R
D
F
L
C
E
A
S
I
M
G
Q
F
D
H
P
N
V
V
H
L
E
G
V
V
T
R
G
K
P
V
M
I
V
I
E
F
M
E
N
G
A
L
D
A
F
L
R
K
H
D
-
G
Q
F
T
V
I
-
Q
-
L
V
G
M
L
R
G
I
A
A
G
M
R
Y
L
A
D
M
G
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
---------------------------
P
V
R
W
T
A
P
E
A
I
Q
Y
R
K
F
T
S
A
S
D
V
W
S
Y
G
I
V
M
W
E
V
M
S
Y
G
E
R
P
Y
W
D
M
S
N
Q
D
V
I
K
A
I
E
E
G
Y
R
L
P
A
P
M
D
C
P
A
G
L
H
Q
L
M
L
D
C
W
Q
K
E
R
A
E
R
P
K
F
E
Q
I
V
G
I
L
D
K
M
I
R
N
P
N
S
A
H
H
---------------------------------------------------------------------------------------------
29
PsiBlast_CBE
71.97
64%
-111
- C2 -
4G2F
1
A:
[23-317]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
H
E
F
A
K
E
L
D
A
T
N
I
S
I
D
-
K
-
V
V
G
A
G
E
F
G
E
V
C
S
G
R
L
K
L
P
S
-
K
-
K
-
E
I
S
V
A
I
K
T
L
K
V
G
Y
-
T
E
K
Q
R
R
D
F
L
G
E
A
S
I
M
G
Q
F
D
H
P
N
I
I
R
L
E
G
V
V
T
K
S
K
P
V
M
I
V
T
E
Y
M
E
N
G
S
L
D
S
F
L
R
K
H
D
-
A
Q
F
T
V
I
-
Q
-
L
V
G
M
L
R
G
I
A
S
G
M
K
Y
L
S
D
M
G
Y
V
H
R
D
L
A
A
R
N
I
L
I
N
S
N
L
V
C
K
V
S
D
F
G
L
S
R
V
L
----------------------
P
I
R
W
T
S
P
E
A
I
A
Y
R
K
F
T
S
A
S
D
V
W
S
Y
G
I
V
L
W
E
V
M
S
Y
G
E
R
P
Y
W
E
M
S
N
Q
D
V
I
K
A
V
D
E
G
Y
R
L
P
P
P
M
D
C
P
A
A
L
Y
Q
L
M
L
D
C
W
Q
K
D
R
N
N
R
P
K
F
E
Q
I
V
S
I
L
D
K
L
I
R
N
P
G
S
L
K
I
I
T
-----
P
S
N
L
L
L
--------------------------------------------------------------------------------
59
PsiBlast_CBE
71.81
67%
-109
- C2 -
2VWX
1
A:
[11-291]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
E
I
D
V
S
Y
V
K
I
E
-
E
-
V
I
G
A
G
E
F
G
E
V
C
R
G
R
L
K
-
A
P
G
K
-
K
-
E
S
C
V
A
I
K
T
L
K
G
G
Y
-
T
E
R
Q
R
R
E
F
L
S
E
A
S
I
M
G
Q
F
E
H
P
N
I
I
R
L
E
G
V
V
T
N
S
M
P
V
M
I
L
T
E
F
M
E
N
G
A
L
D
S
F
L
R
L
N
D
-
G
Q
F
T
V
I
-
Q
-
L
V
G
M
L
R
G
I
A
S
G
M
R
Y
L
A
E
M
S
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
S
R
F
L
E
E
NSS
D
----------
G
G
--
K
I
P
I
R
W
T
A
P
E
A
I
A
F
R
K
F
T
S
A
S
D
A
W
S
Y
G
I
V
M
W
E
V
M
S
F
G
E
R
P
Y
W
D
M
S
N
Q
D
V
I
N
A
I
E
Q
D
Y
R
L
P
P
P
P
D
C
P
T
S
L
H
Q
L
M
L
D
C
W
Q
K
D
R
N
A
R
P
R
F
P
Q
V
V
S
A
L
D
K
M
I
R
N
P
A
S
L
K
I
V
A
-------------------------------------------------------------------------------------------
15
PsiBlast_PDB
71.64
65%
-108
- C2 -
2QO7
4
A:
[21-330]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
Y
V
D
P
H
T
-------
V
H
E
F
A
K
E
L
D
A
T
N
I
S
I
D
-
K
-
V
V
G
A
G
E
F
G
E
V
C
S
G
R
L
K
L
P
S
-
K
-
K
-
E
I
S
V
A
I
K
T
L
K
V
G
Y
-
T
E
K
Q
R
R
D
F
L
G
E
A
S
I
M
G
Q
F
D
H
P
N
I
I
R
L
E
G
V
V
T
K
S
K
P
V
M
I
V
T
E
Y
M
E
N
G
S
L
D
S
F
L
R
K
H
D
-
A
Q
F
T
V
I
-
Q
-
L
V
G
M
L
R
G
I
A
S
G
M
K
Y
L
S
D
M
G
Y
V
H
R
D
L
A
A
R
N
I
L
I
N
S
N
L
V
C
K
V
S
D
F
G
---------------------------
P
I
R
W
T
S
P
E
A
I
A
Y
R
K
F
T
S
A
S
D
V
W
S
Y
G
I
V
L
W
E
V
M
S
Y
G
E
R
P
Y
W
E
M
S
N
Q
D
V
I
K
A
V
D
E
G
Y
R
L
P
P
P
M
D
C
P
A
A
L
Y
Q
L
M
L
D
C
W
Q
K
D
R
N
N
R
P
K
F
E
Q
I
V
S
I
L
D
K
L
I
R
N
P
G
S
L
K
I
I
T
S
----
P
S
N
L
L
L
D
-------------------------------------------------------------------------------
23
PsiBlast_CBE
71.57
64%
-109
- C2 -
4TWO
1
A:
[23-320]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
H
E
F
A
K
E
L
D
A
T
N
I
S
I
D
-
K
-
V
V
G
A
G
E
F
G
E
V
C
S
G
R
L
K
L
P
S
-
K
-
K
-
E
I
S
V
A
I
K
T
L
K
V
G
Y
-
T
E
K
Q
R
R
D
F
L
G
E
A
S
I
M
G
Q
F
D
H
P
N
I
I
R
L
E
G
V
V
T
K
S
K
P
V
M
I
V
T
E
Y
M
E
N
G
S
L
D
S
F
L
R
K
H
D
-
A
Q
F
T
V
I
-
Q
-
L
V
G
M
L
R
G
I
A
S
G
M
K
Y
L
S
D
M
G
Y
V
H
R
D
L
A
A
R
N
I
L
I
N
S
N
L
V
C
K
V
S
D
F
G
L
S
R
V
L
----------------------
P
I
R
W
T
S
P
E
A
I
A
Y
R
K
F
T
S
A
S
D
V
W
S
Y
G
I
V
L
W
E
V
M
S
Y
G
E
R
P
Y
W
E
M
S
N
Q
D
V
I
K
A
V
D
E
G
Y
R
L
P
P
P
M
D
C
P
A
A
L
Y
Q
L
M
L
D
C
W
Q
K
D
R
N
N
R
P
K
F
E
Q
I
V
S
I
L
D
K
L
I
R
N
P
G
S
L
K
I
I
T
-----
P
S
N
L
L
L
D
Q
S
-----------------------------------------------------------------------------
48
PsiBlast_CBE
71.53
71%
-110
- C2 -
2HEN
1
EPHB2_MOUSE
B:
[1-281]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
K
E
I
D
I
S
C
V
K
I
E
-
Q
-
V
I
G
A
G
E
F
G
E
V
C
S
G
H
L
K
L
P
-
G
K
-
R
-
E
I
F
V
A
I
K
T
L
K
S
G
Y
-
T
E
K
Q
R
R
D
F
L
S
E
A
S
I
M
G
Q
F
D
H
P
N
V
I
H
L
E
G
V
V
T
K
S
T
P
V
M
I
I
T
E
F
M
E
N
G
S
L
D
S
F
L
R
Q
N
D
-
G
Q
F
T
V
I
-
Q
-
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
D
M
N
Y
V
H
R
A
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
---------------------------
P
I
R
W
T
A
P
E
A
I
Q
Y
R
K
F
T
S
A
S
D
V
W
S
Y
G
I
V
M
W
E
V
M
S
Y
G
E
R
P
Y
W
D
M
T
N
Q
D
V
I
N
A
I
E
Q
D
Y
R
L
P
P
P
M
D
C
P
S
A
L
H
Q
L
M
L
D
C
W
Q
K
D
R
N
H
R
P
K
F
G
Q
I
V
N
T
L
D
K
M
I
R
N
P
N
S
L
K
A
M
--------------------------------------------------------------------------------------------
30
PsiBlast_CBE
71.14
64%
-115
- C2 -
3DZQ
1
A:
[23-318]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
H
E
F
A
K
E
L
D
A
T
N
I
S
I
D
-
K
-
V
V
G
A
G
E
F
G
E
V
C
S
G
R
L
K
L
P
S
-
K
-
K
-
E
I
S
V
A
I
K
T
L
K
V
G
Y
-
T
E
K
Q
R
R
D
F
L
G
E
A
S
I
M
G
Q
F
D
H
P
N
I
I
R
L
E
G
V
V
T
K
S
K
P
V
M
I
V
T
E
Y
M
E
N
G
S
L
D
S
F
L
R
K
H
D
-
A
Q
F
T
V
I
-
Q
-
L
V
G
M
L
R
G
I
A
S
G
M
K
Y
L
S
D
M
G
Y
V
H
R
D
L
A
A
R
N
I
L
I
N
S
N
L
V
C
K
V
S
D
F
G
L
--------------------------
P
I
R
W
T
S
P
E
A
I
A
Y
R
K
F
T
S
A
S
D
V
W
S
Y
G
I
V
L
W
E
V
M
S
Y
G
E
R
P
Y
W
E
M
S
N
Q
D
V
I
K
A
V
D
E
G
Y
R
L
P
P
P
M
D
C
P
A
A
L
Y
Q
L
M
L
D
C
W
Q
K
D
R
N
N
R
P
K
F
E
Q
I
V
S
I
L
D
K
L
I
R
N
P
--
L
K
I
I
T
-------
N
L
L
L
D
-------------------------------------------------------------------------------
47
PsiBlast_CBE
70.95
71%
-108
- C2 -
2HEN
1
EPHB2_MOUSE
C:
[1-281]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
K
E
I
D
I
S
C
V
K
I
E
-
Q
-
V
I
G
A
G
E
F
G
E
V
C
S
G
H
L
K
L
P
-
G
K
-
R
-
E
I
F
V
A
I
K
T
L
K
S
G
Y
-
T
E
K
Q
R
R
D
F
L
S
E
A
S
I
M
G
Q
F
D
H
P
N
V
I
H
L
E
G
V
V
T
K
S
T
P
V
M
I
I
T
E
F
M
E
N
G
S
L
D
S
F
L
R
Q
N
D
-
G
Q
F
T
V
I
-
Q
-
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
D
M
N
Y
V
H
R
A
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
---------------------------
P
I
R
W
T
A
P
E
A
I
Q
Y
R
K
F
T
S
A
S
D
V
W
S
Y
G
I
V
M
W
E
V
M
S
Y
G
E
R
P
Y
W
D
M
T
N
Q
D
V
I
N
A
I
E
Q
D
Y
R
L
P
P
P
M
D
C
P
S
A
L
H
Q
L
M
L
D
C
W
Q
K
D
R
N
H
R
P
K
F
G
Q
I
V
N
T
L
D
K
M
I
R
N
P
N
S
L
K
A
M
--------------------------------------------------------------------------------------------
49
PsiBlast_CBE
70.81
71%
-110
- C2 -
2HEN
1
EPHB2_MOUSE
A:
[1-281]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
K
E
I
D
I
S
C
V
K
I
E
-
Q
-
V
I
G
A
G
E
F
G
E
V
C
S
G
H
L
K
L
P
-
G
K
-
R
-
E
I
F
V
A
I
K
T
L
K
S
G
Y
-
T
E
K
Q
R
R
D
F
L
S
E
A
S
I
M
G
Q
F
D
H
P
N
V
I
H
L
E
G
V
V
T
K
S
T
P
V
M
I
I
T
E
F
M
E
N
G
S
L
D
S
F
L
R
Q
N
D
-
G
Q
F
T
V
I
-
Q
-
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
D
M
N
Y
V
H
R
A
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
---------------------------
P
I
R
W
T
A
P
E
A
I
Q
Y
R
K
F
T
S
A
S
D
V
W
S
Y
G
I
V
M
W
E
V
M
S
Y
G
E
R
P
Y
W
D
M
T
N
Q
D
V
I
N
A
I
E
Q
D
Y
R
L
P
P
P
M
D
C
P
S
A
L
H
Q
L
M
L
D
C
W
Q
K
D
R
N
H
R
P
K
F
G
Q
I
V
N
T
L
D
K
M
I
R
N
P
N
S
L
K
A
M
--------------------------------------------------------------------------------------------
25
PsiBlast_CBE
70.78
64%
-110
- C2 -
4P4C
1
A:
[27-318]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
K
E
L
D
A
T
N
I
S
I
D
-
K
-
V
V
G
A
G
E
F
G
E
V
C
S
G
R
L
K
L
P
S
-
K
-
K
-
E
I
S
V
A
I
K
T
L
K
V
G
Y
-
T
E
K
Q
R
R
D
F
L
G
E
A
S
I
M
G
Q
F
D
H
P
N
I
I
R
L
E
G
V
V
T
K
S
K
P
V
M
I
V
T
E
Y
M
E
N
G
S
L
D
S
F
L
R
K
H
D
-
A
Q
F
T
V
I
-
Q
-
L
V
G
M
L
R
G
I
A
S
G
M
K
Y
L
S
D
M
G
Y
V
H
R
D
L
A
A
R
N
I
L
I
N
S
N
L
V
C
K
V
S
D
F
----------------------------
P
I
R
W
T
S
P
E
A
I
A
Y
R
K
F
T
S
A
S
D
V
W
S
Y
G
I
V
L
W
E
V
M
S
Y
G
E
R
P
Y
W
E
M
S
N
Q
D
V
I
K
A
V
D
E
G
Y
R
L
P
P
P
M
D
C
P
A
A
L
Y
Q
L
M
L
D
C
W
Q
K
D
R
N
N
R
P
K
F
E
Q
I
V
S
I
L
D
K
L
I
R
N
P
G
S
L
K
I
I
T
-----
P
S
N
L
L
L
D
-------------------------------------------------------------------------------
46
PsiBlast_CBE
70.76
71%
-109
- C2 -
2HEN
1
D:
[1-281]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
K
E
I
D
I
S
C
V
K
I
E
-
Q
-
V
I
G
A
G
E
F
G
E
V
C
S
G
H
L
K
L
P
-
G
K
-
R
-
E
I
F
V
A
I
K
T
L
K
S
G
Y
-
T
E
K
Q
R
R
D
F
L
S
E
A
S
I
M
G
Q
F
D
H
P
N
V
I
H
L
E
G
V
V
T
K
S
T
P
V
M
I
I
T
E
F
M
E
N
G
S
L
D
S
F
L
R
Q
N
D
-
G
Q
F
T
V
I
-
Q
-
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
D
M
N
Y
V
H
R
A
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
---------------------------
P
I
R
W
T
A
P
E
A
I
Q
Y
R
K
F
T
S
A
S
D
V
W
S
Y
G
I
V
M
W
E
V
M
S
Y
G
E
R
P
Y
W
D
M
T
N
Q
D
V
I
N
A
I
E
Q
D
Y
R
L
P
P
P
M
D
C
P
S
A
L
H
Q
L
M
L
D
C
W
Q
K
D
R
N
H
R
P
K
F
G
Q
I
V
N
T
L
D
K
M
I
R
N
P
N
S
L
K
A
M
--------------------------------------------------------------------------------------------
53
PsiBlast_CBE
70.62
67%
-105
- C2 -
2XVD
1
A:
[10-291]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
K
E
I
D
V
S
Y
V
K
I
E
-
E
-
V
I
G
A
G
E
F
G
E
V
C
R
G
R
L
K
-
A
P
G
K
-
K
-
E
S
C
V
A
I
K
T
L
---
Y
-
T
E
R
Q
R
R
E
F
L
S
E
A
S
I
M
G
Q
F
E
H
P
N
I
I
R
L
E
G
V
V
T
N
S
M
P
V
M
I
L
T
E
F
M
E
N
G
A
L
D
S
F
L
R
L
N
D
-
G
Q
F
T
V
I
-
Q
-
L
V
G
M
L
R
G
I
A
S
G
M
R
Y
L
A
E
M
S
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
S
R
F
L
E
----------
S
-
S
-
L
G
G
--
K
I
P
I
R
W
T
A
P
E
A
I
A
F
R
K
F
T
S
A
S
D
A
W
S
Y
G
I
V
M
W
E
V
M
S
F
G
E
R
P
Y
W
D
M
S
N
Q
D
V
I
N
A
I
E
Q
D
Y
R
L
P
P
P
P
D
C
P
T
S
L
H
Q
L
M
L
D
C
W
Q
K
D
R
N
A
R
P
R
F
P
Q
V
V
S
A
L
D
K
M
I
R
N
P
A
S
L
K
I
V
A
-------------------------------------------------------------------------------------------
50
PsiBlast_CBE
70.43
68%
-113
- C2 -
2YN8
1
B:
[12-294]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
A
K
E
I
D
V
S
Y
V
K
I
E
-
E
-
V
I
G
A
G
E
F
G
E
V
C
R
G
R
L
K
-
A
P
G
K
-
K
-
E
S
C
V
A
I
K
T
L
K
G
G
Y
-
T
E
R
Q
R
R
E
F
L
S
E
A
S
I
M
G
Q
F
E
H
P
N
I
I
R
L
E
G
V
V
T
N
S
M
P
V
M
I
L
T
E
F
M
E
N
G
A
L
D
S
F
L
R
L
N
D
-
G
Q
F
T
V
I
-
Q
-
L
V
G
M
L
R
G
I
A
S
G
M
R
Y
L
A
E
M
S
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
----------------------------
P
I
R
W
T
A
P
E
A
I
A
F
R
K
F
T
S
A
S
D
V
W
S
Y
G
I
V
M
W
E
V
M
S
F
G
E
R
P
Y
W
D
M
S
N
Q
D
V
I
N
A
I
E
Q
D
Y
R
L
P
P
P
P
D
C
P
T
S
L
H
Q
L
M
L
D
C
W
Q
K
D
R
N
A
R
P
R
F
P
Q
I
V
S
A
L
D
K
M
I
R
N
P
A
S
L
K
I
V
A
-------------------------------------------------------------------------------------------
24
PsiBlast_CBE
70.42
64%
-112
- C2 -
4TWN
1
A:
[22-318]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
V
H
E
F
A
K
E
L
D
A
T
N
I
S
I
D
-
K
-
V
V
G
A
G
E
F
G
E
V
C
S
G
R
L
K
L
P
S
-
K
-
K
-
E
I
S
V
A
I
K
T
L
K
V
G
Y
-
T
E
K
Q
R
R
D
F
L
G
E
A
S
I
M
G
Q
F
D
H
P
N
I
I
R
L
E
G
V
V
T
K
S
K
P
V
M
I
V
T
E
Y
M
E
N
G
S
L
D
S
F
L
R
K
H
D
-
A
Q
F
T
V
I
-
Q
-
L
V
G
M
L
R
G
I
A
S
G
M
K
Y
L
S
D
M
G
Y
V
H
R
D
L
A
A
R
N
I
L
I
N
S
N
L
V
C
K
V
S
D
F
G
L
S
R
----------------------
K
I
P
I
R
W
T
S
P
E
A
I
A
Y
R
K
F
T
S
A
S
D
V
W
S
Y
G
I
V
L
W
E
V
M
S
Y
G
E
R
P
Y
W
E
M
S
N
Q
D
V
I
K
A
V
D
E
G
Y
R
L
P
P
P
M
D
C
P
A
A
L
Y
Q
L
M
L
D
C
W
Q
K
D
R
N
N
R
P
K
F
E
Q
I
V
S
I
L
D
K
L
I
R
N
P
G
S
L
K
I
I
T
------
S
N
L
L
L
D
-------------------------------------------------------------------------------
51
PsiBlast_CBE
70.33
68%
-115
- C2 -
2YN8
1
EPHB4_HUMAN
A:
[14-294]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
E
I
D
V
S
Y
V
K
I
E
-
E
-
V
I
G
A
G
E
F
G
E
V
C
R
G
R
L
K
--------
E
S
C
V
A
I
K
T
L
K
G
G
Y
-
T
E
R
Q
R
R
E
F
L
S
E
A
S
I
M
G
Q
F
E
H
P
N
I
I
R
L
E
G
V
V
T
N
S
M
P
V
M
I
L
T
E
F
M
E
N
G
A
L
D
S
F
L
R
L
N
D
-
G
Q
F
T
V
I
-
Q
-
L
V
G
M
L
R
G
I
A
S
G
M
R
Y
L
A
E
M
S
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
----------------------------
P
I
R
W
T
A
P
E
A
I
A
F
R
K
F
T
S
A
S
D
V
W
S
Y
G
I
V
M
W
E
V
M
S
F
G
E
R
P
Y
W
D
M
S
N
Q
D
V
I
N
A
I
E
Q
D
Y
R
L
P
P
P
P
D
C
P
T
S
L
H
Q
L
M
L
D
C
W
Q
K
D
R
N
A
R
P
R
F
P
Q
I
V
S
A
L
D
K
M
I
R
N
P
A
S
L
K
I
V
A
-------------------------------------------------------------------------------------------
60
PsiBlast_CBE
70.30
67%
-112
- C2 -
4AW5
1
A:
[8-289]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
K
E
I
D
V
S
Y
V
K
I
E
-
E
-
V
I
G
A
G
E
F
G
E
V
C
R
G
R
L
K
-
A
P
G
K
-
K
-
E
S
C
V
A
I
K
T
L
K
G
G
Y
-
T
E
R
Q
R
R
E
F
L
S
E
A
S
I
M
G
Q
F
E
H
P
N
I
I
R
L
E
G
V
V
T
N
S
M
P
V
M
I
L
T
E
F
M
E
N
G
A
L
D
S
F
L
R
L
N
D
-
G
Q
F
T
V
I
-
Q
-
L
V
G
M
L
R
G
I
A
S
G
M
R
Y
L
A
E
M
S
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
--------------------------
I
P
I
R
W
T
A
P
E
A
I
A
F
R
K
F
T
S
A
S
D
A
W
S
Y
G
I
V
M
W
E
V
M
S
F
G
E
R
P
Y
W
D
M
S
N
Q
D
V
I
N
A
I
E
Q
D
Y
R
L
P
P
P
P
D
C
P
T
S
L
H
Q
L
M
L
D
C
W
Q
K
D
R
N
A
R
P
R
F
P
Q
V
V
S
A
L
D
K
M
I
R
N
P
A
S
L
K
I
V
A
-------------------------------------------------------------------------------------------
121
HHSearch
68.14
63%
-109
- C2 -
3KUL
2
EPHA8_HUMAN
A:
[43-316]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
R
E
I
E
A
S
R
I
H
I
E
-
K
-
I
I
G
S
G
D
S
G
E
V
C
Y
G
R
L
R
V
P
-
G
Q
-
R
-
D
V
P
V
A
I
K
A
L
K
A
G
Y
-
T
E
R
Q
R
R
D
F
L
S
E
A
S
I
M
G
Q
F
D
H
P
N
I
I
R
L
E
G
V
V
T
R
G
R
L
A
M
I
V
T
E
Y
M
E
N
G
S
L
D
T
F
L
R
T
H
D
-
G
Q
F
T
I
M
-
Q
-
L
V
G
M
L
R
G
V
G
A
G
M
R
Y
L
S
D
L
G
Y
V
H
R
D
L
A
A
R
N
V
L
V
D
S
N
L
V
C
K
V
S
D
F
G
L
S
R
V
L
E
-------
A
A
Y
T
-
T
-
T
-----
I
P
I
R
W
T
A
P
E
A
I
A
F
R
T
F
S
S
A
S
D
V
W
S
F
G
V
V
M
W
E
V
L
A
Y
G
E
R
P
Y
W
N
M
T
N
R
D
V
I
S
S
V
E
E
G
Y
R
L
P
A
P
M
G
C
P
H
A
L
H
Q
L
M
L
D
C
W
H
K
D
R
A
Q
R
P
R
F
S
Q
I
V
S
V
L
D
A
L
I
R
S
P
E
-------------------------------------------------------------------------------------------------
136
HHSearch
68.10
37%
-106
- C2 -
4FL3
1
KSYK_HUMAN
A:
[364-631]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
L
D
R
K
L
L
T
L
E
D
K
-
E
L
G
S
G
N
F
G
T
V
K
K
G
Y
Y
Q
M
K
--
K
-
V
-
V
K
T
V
A
V
K
I
L
K
N
E
A
N
D
P
A
L
K
D
E
L
L
A
E
A
N
V
M
Q
Q
L
D
N
P
Y
I
V
R
M
I
G
I
C
E
-
A
E
S
W
M
L
V
M
E
M
A
E
L
G
P
L
N
K
Y
L
Q
Q
N
--
R
H
V
K
D
K
-
N
-
I
I
E
L
V
H
Q
V
S
M
G
M
K
Y
L
E
E
S
N
F
V
H
R
D
L
A
A
R
N
V
L
L
V
T
Q
H
Y
A
K
I
S
D
F
G
L
S
K
A
L
R
A
--------------------
P
V
K
W
Y
A
P
E
C
I
N
Y
Y
K
F
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
A
F
S
Y
G
Q
K
P
Y
R
G
M
K
G
S
E
V
T
A
M
L
E
K
G
E
R
M
G
C
P
A
G
C
P
R
E
M
Y
D
L
M
N
L
C
W
T
Y
D
V
E
N
R
P
G
F
A
A
V
E
L
R
L
R
N
Y
Y
Y
D
V
V
N
------------------------------------------------------------------------------------------------
45
PsiBlast_CBE
68.03
62%
-109
- C2 -
3KUL
2
EPHA8_HUMAN
A:
[43-316]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
R
E
I
E
A
S
R
I
H
I
E
-
K
-
I
I
G
S
G
D
S
G
E
V
C
Y
G
R
L
R
V
P
-
G
Q
-
R
-
D
V
P
V
A
I
K
A
L
K
A
G
Y
-
T
E
R
Q
R
R
D
F
L
S
E
A
S
I
M
G
Q
F
D
H
P
N
I
I
R
L
E
G
V
V
T
R
G
R
L
A
M
I
V
T
E
Y
M
E
N
G
S
L
D
T
F
L
R
T
H
D
-
G
Q
F
T
I
M
-
Q
-
L
V
G
M
L
R
G
V
G
A
G
M
R
Y
L
S
D
L
G
Y
V
H
R
D
L
A
A
R
N
V
L
V
D
S
N
L
V
C
K
V
S
D
F
G
L
S
R
V
L
E
-------
A
A
Y
T
-
T
-
T
-----
I
P
I
R
W
T
A
P
E
A
I
A
F
R
T
F
S
S
A
S
D
V
W
S
F
G
V
V
M
W
E
V
L
A
Y
G
E
R
P
Y
W
N
M
T
N
R
D
V
I
S
S
V
E
E
G
Y
R
L
P
A
P
M
G
C
P
H
A
L
H
Q
L
M
L
D
C
W
H
K
D
R
A
Q
R
P
R
F
S
Q
I
V
S
V
L
D
A
L
I
R
S
P
E
-------------------------------------------------------------------------------------------------
134
HHSearch
64.09
40%
-107
- C2 -
2OZO
1
ZAP70_HUMAN
A:
[333-598]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
R
D
N
L
L
I
A
-
D
I
E
L
G
C
G
N
F
G
S
V
R
Q
G
V
Y
R
M
R
--
K
-
K
-
Q
I
D
V
A
I
K
V
L
K
Q
G
T
-
E
K
A
D
T
E
E
M
M
R
E
A
Q
I
M
H
Q
L
D
N
P
Y
I
V
R
L
I
G
V
C
Q
-
A
E
A
L
M
L
V
M
E
M
A
G
G
G
P
L
H
K
F
L
V
G
K
R
-
E
E
I
P
V
S
-
N
-
V
A
E
L
L
H
Q
V
S
M
G
M
K
Y
L
E
E
K
N
F
V
H
R
N
L
A
A
R
N
V
L
L
V
N
R
H
Y
A
K
I
S
D
F
G
L
S
K
A
L
G
---------------------
P
L
K
W
Y
A
P
E
C
I
N
F
R
K
F
S
S
R
S
D
V
W
S
Y
G
V
T
M
W
E
A
L
S
Y
G
Q
K
P
Y
K
K
M
K
G
P
E
V
M
A
F
I
E
Q
G
K
R
M
E
C
P
P
E
C
P
P
E
L
Y
A
L
M
S
D
C
W
I
Y
K
W
E
D
R
P
D
F
L
T
V
E
Q
R
M
R
A
C
Y
Y
S
L
A
S
K
V
E
G
G
S
A
L
E
V
A
-------------------------------------------------------------------------------------
62
PsiBlast_CBE
63.07
45%
-108
- C2 -
4CSV
1
?
A:
[7-268]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
P
R
S
E
I
T
L
E
-
R
-
K
L
G
S
G
Q
F
G
E
V
Y
E
G
K
W
R
N
Y
N
------
I
E
V
A
V
K
T
L
K
E
G
T
-
M
S
V
E
--
E
F
L
Q
E
A
Q
I
M
K
K
L
K
H
P
N
L
V
Q
L
Y
G
V
C
T
K
E
P
P
I
Y
I
I
T
E
Y
M
S
H
G
S
L
L
D
Y
L
R
D
C
-----
V
N
A
-
Q
A
L
L
D
M
A
A
Q
V
A
S
G
M
A
Y
L
E
S
Q
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
N
V
V
K
V
A
D
F
G
--------------------------
F
P
I
K
W
T
A
P
E
A
I
S
Y
N
R
F
S
I
K
S
D
V
W
A
F
G
I
L
L
W
E
I
F
T
Y
G
Q
V
P
Y
P
G
M
S
G
S
E
V
I
E
Q
V
E
R
G
Y
R
M
P
R
P
Q
G
C
P
E
E
I
Y
E
L
M
L
Q
C
W
N
K
S
P
E
E
R
P
T
F
A
E
T
L
H
A
L
E
T
M
F
L
----------------------------------------------------------------------------------------------------
133
HHSearch
62.63
44%
-104
- C2 -
1QCF
1
HCK_HUMAN
A:
[182-447]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
W
E
I
P
R
E
S
L
K
L
E
-
K
-
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
N
--
K
-----
H
T
K
V
A
V
K
T
M
K
P
G
S
-
M
S
--
V
E
A
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
-
K
E
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
E
G
S
K
Q
P
L
P
-
K
-
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
E
D
---
N
---
E
Y
T
-
A
R
E
G
A
--
K
F
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
T
A
T
E
S
Q
Y
E
E
I
P
------------------------------------------------------------------------------------------
137
HHSearch
62.31
40%
-105
- C2 -
1U59
1
A:
[6-272]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
R
D
N
L
L
I
A
-
D
I
E
L
G
C
G
N
F
G
S
V
R
Q
G
V
Y
R
------
K
-
Q
I
D
V
A
I
K
V
L
K
Q
G
T
-
E
K
A
D
T
E
E
M
M
R
E
A
Q
I
M
H
Q
L
D
N
P
Y
I
V
R
L
I
G
V
C
Q
-
A
E
A
L
M
L
V
M
E
M
A
G
G
G
P
L
H
K
F
L
V
G
K
R
-
E
E
I
P
V
S
-
N
-
V
A
E
L
L
H
Q
V
S
M
G
M
K
Y
L
E
E
K
N
F
V
H
R
D
L
A
A
R
N
V
L
L
V
N
R
H
Y
A
K
I
S
D
F
G
L
S
K
A
L
G
A
---
D
D
S
-
Y
Y
T
A
R
-
S
A
G
--
K
W
P
L
K
W
Y
A
P
E
C
I
N
F
R
K
F
S
S
R
S
D
V
W
S
Y
G
V
T
M
W
E
A
L
S
Y
G
Q
K
P
Y
K
K
M
K
G
P
E
V
M
A
F
I
E
Q
G
K
R
M
E
C
P
P
E
C
P
P
E
L
Y
A
L
M
S
D
C
W
I
Y
K
W
E
D
R
P
D
F
L
T
V
E
Q
R
M
R
A
C
Y
Y
S
L
A
S
K
V
E
G
H
H
H
H
H
H
--------------------------------------------------------------------------------------
65
PsiBlast_CBE
62.21
42%
-103
- C2 -
4LUD
2
HCK_HUMAN
B:
[174-448]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
Q
K
P
W
E
K
D
A
W
E
I
P
R
E
S
L
K
L
E
-
K
-
K
L
G
A
G
Q
F
G
E
V
W
-----
M
A
T
Y
N
-
K
-
H
T
K
V
A
V
K
T
M
K
P
G
---
S
V
E
A
--
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
-
E
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
E
-
G
S
K
Q
P
L
P
K
-
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
----------------------
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
T
A
T
E
S
Q
Y
E
E
--------------------------------------------------------------------------------------------
98
PsiBlast_CBE
61.91
41%
-88
- C2 -
2H8H
1
SRC_HUMAN
A:
[198-519]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
L
N
V
K
H
Y
K
I
R
K
L
D
S
G
G
F
Y
I
T
S
R
T
Q
F
N
S
L
Q
Q
L
V
--
A
Y
Y
S
K
H
A
D
G
L
C
H
R
L
T
T
V
C
P
-
T
S
K
P
Q
T
Q
G
L
A
K
D
A
W
E
I
P
R
E
S
L
R
L
E
-
V
-
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
G
T
T
R
-------
V
A
I
K
T
L
K
P
G
T
-
M
S
P
E
--
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
-
E
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
T
-
G
K
Y
L
R
L
P
Q
-
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
E
D
---
N
---
E
Y
T
-
A
R
Q
G
A
--
K
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
P
--------------------------------------------------------------------------------------------
128
HHSearch
61.72
38%
-106
- C2 -
3POZ
1
A:
[6-283]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
A
L
L
R
I
L
K
E
---
T
E
F
K
K
I
-
K
-
V
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
I
P
------V
K
I
P
V
A
I
K
E
L
--------
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
L
T
-
S
T
V
Q
L
I
T
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
H
K
-
D
N
I
G
S
Q
-
Y
-
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
A
K
L
L
G
A
---
E
-
E
K
-----------
K
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
S
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
D
E
R
M
H
L
P
S
P
T
D
S
N
F
Y
R
A
L
M
D
V
V
D
A
D
E
Y
L
--------------------------------------------------------------
101
PsiBlast_CBE
61.64
42%
-85
- C2 -
2SRC
1
SRC_HUMAN
A:
[130-436]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
F
Y
I
T
S
R
T
Q
F
N
S
L
Q
Q
L
V
--
A
Y
Y
S
K
H
A
D
G
L
C
H
R
L
T
T
V
C
P
-
T
S
K
P
Q
T
Q
G
L
A
K
D
A
W
E
I
P
R
E
S
L
R
L
E
-
V
-
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
G
T
T
R
-------
V
A
I
K
T
L
K
P
G
T
-
M
S
P
E
--
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
-
E
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
T
-
G
K
Y
L
R
L
P
Q
-
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
E
D
---
N
---
E
Y
T
-
A
R
Q
G
A
--
K
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
P
G
E
N
L
----------------------------------------------------------------------------------------
70
PsiBlast_CBE
61.52
42%
-100
- C2 -
3VS5
1
HCK_HUMAN
B:
[174-448]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
Q
K
P
W
E
K
D
A
W
E
I
P
R
E
S
L
K
L
E
-
K
-
K
L
G
A
G
Q
F
G
E
V
W
-----
M
A
T
Y
N
-
K
-
H
T
K
V
A
V
K
T
M
K
P
G
S
-
M
S
V
E
A
--
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
-
E
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
E
-
G
S
K
Q
P
L
P
K
-
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
----------------------
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
T
A
T
E
S
Q
Y
E
E
I
P
------------------------------------------------------------------------------------------
64
PsiBlast_CBE
61.31
42%
-106
- C2 -
4LUE
3
HCK_HUMAN
A:
[174-448]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
Q
K
P
W
E
K
D
A
W
E
I
P
R
E
S
L
K
L
E
-
K
-
K
L
G
A
G
Q
F
G
E
V
W
-----
M
A
T
Y
N
-
K
-
H
T
K
V
A
V
K
T
M
K
P
G
S
---------
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
-
E
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
E
-
G
S
K
Q
P
L
P
K
-
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
----------------------
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
T
A
T
E
S
Q
Y
E
E
I
-------------------------------------------------------------------------------------------
86
PsiBlast_CBE
61.23
42%
-97
- C2 -
2C0T
1
HCK_HUMAN
B:
[174-448]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
Q
K
P
W
E
K
D
A
W
E
I
P
R
E
S
L
K
L
E
-
K
-
K
L
G
A
G
Q
F
G
E
V
W
-----
M
A
T
Y
N
-
K
-
H
T
K
V
A
V
K
T
M
K
P
G
S
-
M
S
V
E
A
--
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
-
E
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
E
-
G
S
K
Q
P
L
P
K
-
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
----------------------
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
T
A
T
E
S
Q
Y
E
E
I
P
------------------------------------------------------------------------------------------
91
PsiBlast_CBE
61.22
42%
-100
- C2 -
2C0I
1
HCK_HUMAN
A:
[174-448]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
Q
K
P
W
E
K
D
A
W
E
I
P
R
E
S
L
K
L
E
-
K
-
K
L
G
A
G
Q
F
G
E
V
W
-----
M
A
T
Y
N
-
K
-
H
T
K
V
A
V
K
T
M
K
P
G
S
-
M
S
V
E
A
--
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
-
E
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
E
-
G
S
K
Q
P
L
P
K
-
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
----------------------
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
T
A
T
E
S
Q
Y
E
E
I
P
------------------------------------------------------------------------------------------
82
PsiBlast_CBE
61.16
42%
-100
- C2 -
3VRZ
1
HCK_HUMAN
B:
[174-448]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
Q
K
P
W
E
K
D
A
W
E
I
P
R
E
S
L
K
L
E
-
K
-
K
L
G
A
G
Q
F
G
E
V
W
-----
M
A
T
Y
N
-
K
-
H
T
K
V
A
V
K
T
M
K
P
G
S
-
M
S
V
E
A
--
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
-
E
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
E
-
G
S
K
Q
P
L
P
K
-
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
---------------------
F
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
T
A
T
E
S
Q
Y
E
E
I
P
------------------------------------------------------------------------------------------
89
PsiBlast_CBE
61.03
42%
-102
- C2 -
2C0O
1
HCK_HUMAN
A:
[174-448]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
Q
K
P
W
E
K
D
A
W
E
I
P
R
E
S
L
K
L
E
-
K
-
K
L
G
A
G
Q
F
G
E
V
W
-----
M
A
T
Y
N
-
K
-
H
T
K
V
A
V
K
T
M
K
P
G
S
-
M
S
V
E
A
--
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
-
E
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
E
-
G
S
K
Q
P
L
P
K
-
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
----------------------
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
T
A
T
E
S
Q
Y
E
E
I
P
------------------------------------------------------------------------------------------
132
HHSearch
61.02
33%
-103
- C2 -
4OTW
1
A:
[9-281]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
F
K
E
T
E
L
R
K
L
-
K
-
V
L
G
S
G
V
F
G
T
V
H
K
G
V
W
I
P
E
-
G
E
S
I
-
K
I
P
V
C
I
K
V
I
E
D
K
S
-
G
R
Q
S
F
Q
A
V
T
D
H
M
L
A
I
G
S
L
D
H
A
H
I
V
R
L
L
G
L
C
P
G
-
S
S
L
Q
L
V
T
Q
Y
L
P
L
G
S
L
L
D
H
V
R
Q
H
R
-
G
A
L
G
P
Q
-
L
-
L
L
N
W
G
V
Q
I
A
K
G
M
Y
Y
L
E
E
H
G
M
V
H
R
N
L
A
A
R
N
V
L
L
K
S
P
S
Q
V
Q
V
A
D
F
G
V
A
D
L
L
P
P
---
D
--------------
K
T
P
I
K
W
M
A
L
E
S
I
H
F
G
K
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
A
E
P
Y
A
G
L
R
L
A
E
V
P
D
L
L
E
K
G
E
R
L
A
Q
P
Q
I
C
T
I
D
V
Y
M
V
M
V
K
C
W
M
I
D
E
N
I
R
P
T
F
K
E
L
A
N
E
F
T
R
M
A
R
D
P
P
R
Y
L
V
I
K
-------------------------------------------------------------------------------------------
93
PsiBlast_CBE
61.00
44%
-97
- C2 -
2HK5
1
HCK_HUMAN
A:
[11-267]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
P
R
E
S
L
K
L
E
-
K
-
K
L
G
A
G
Q
F
G
E
V
W
-----
M
A
T
Y
N
-
K
-
H
T
K
V
A
V
K
T
M
K
P
G
S
-
M
S
V
E
A
--
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
-
E
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
E
-
G
S
K
Q
P
L
P
K
-
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
E
D
---
N
---
E
Y
T
-
A
R
E
G
A
--
K
F
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
------------------------------------------------------------------------------------------------------
74
PsiBlast_CBE
60.86
42%
-99
- C2 -
3VS3
1
HCK_HUMAN
B:
[174-448]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
Q
K
P
W
E
K
D
A
W
E
I
P
R
E
S
L
K
L
E
-
K
-
K
L
G
A
G
Q
F
G
E
V
W
-----
M
A
T
Y
N
-
K
-
H
T
K
V
A
V
K
T
M
K
P
G
S
-
M
S
V
E
A
--
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
-
E
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
E
-
G
S
K
Q
P
L
P
K
-
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
E
-------------------
K
F
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
T
A
T
E
S
Q
Y
E
E
I
P
------------------------------------------------------------------------------------------
71
PsiBlast_CBE
60.81
42%
-102
- C2 -
3VS5
1
HCK_HUMAN
A:
[174-448]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
Q
K
P
W
E
K
D
A
W
E
I
P
R
E
S
L
K
L
E
-
K
-
K
L
G
A
G
Q
F
G
E
V
W
-----
M
A
T
Y
N
-
K
-
H
T
K
V
A
V
K
T
M
K
P
G
S
-
M
S
V
E
A
--
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
-
E
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
E
-
G
S
K
Q
P
L
P
K
-
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
----------------------
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
T
A
T
E
S
Q
Y
E
E
I
P
------------------------------------------------------------------------------------------
73
PsiBlast_CBE
60.58
42%
-98
- C2 -
3VS4
1
HCK_HUMAN
A:
[174-448]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
Q
K
P
W
E
K
D
A
W
E
I
P
R
E
S
L
K
L
E
-
K
-
K
L
G
A
G
Q
F
G
E
V
W
-----
M
A
T
Y
N
-
K
-
H
T
K
V
A
V
K
T
M
K
P
G
S
-
M
S
V
E
A
--
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
-
E
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
E
-
G
S
K
Q
P
L
P
K
-
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
E
--------------------
F
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
T
A
T
E
S
Q
Y
E
E
I
P
------------------------------------------------------------------------------------------
69
PsiBlast_CBE
60.57
42%
-103
- C2 -
3VS6
1
HCK_HUMAN
A:
[174-448]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
Q
K
P
W
E
K
D
A
W
E
I
P
R
E
S
L
K
L
E
-
K
-
K
L
G
A
G
Q
F
G
E
V
W
-----
M
A
T
Y
N
-
K
-
H
T
K
V
A
V
K
T
M
K
P
G
S
-
M
S
V
E
A
--
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
-
E
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
E
-
G
S
K
Q
P
L
P
K
-
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
---------------------
F
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
T
A
T
E
S
Q
Y
E
E
I
P
------------------------------------------------------------------------------------------
72
PsiBlast_CBE
60.55
42%
-99
- C2 -
3VS4
1
HCK_HUMAN
B:
[174-448]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
Q
K
P
W
E
K
D
A
W
E
I
P
R
E
S
L
K
L
E
-
K
-
K
L
G
A
G
Q
F
G
E
V
W
-----
M
A
T
Y
N
-
K
-
H
T
K
V
A
V
K
T
M
K
P
G
S
-
M
S
V
E
A
--
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
-
E
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
E
-
G
S
K
Q
P
L
P
K
-
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
---------------------
F
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
T
A
T
E
S
Q
Y
E
E
I
P
------------------------------------------------------------------------------------------
87
PsiBlast_CBE
60.46
42%
-97
- C2 -
2C0T
1
HCK_HUMAN
A:
[174-448]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
Q
K
P
W
E
K
D
A
W
E
I
P
R
E
S
L
K
L
E
-
K
-
K
L
G
A
G
Q
F
G
E
V
W
-----
M
A
T
Y
N
-
K
-
H
T
K
V
A
V
K
T
M
K
P
G
S
-
M
S
V
E
A
--
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
-
E
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
E
-
G
S
K
Q
P
L
P
K
-
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
----------------------
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
T
A
T
E
S
Q
Y
E
E
I
P
------------------------------------------------------------------------------------------
63
PsiBlast_CBE
60.46
42%
-107
- C2 -
4LUE
3
HCK_HUMAN
B:
[174-448]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
Q
K
P
W
E
K
D
A
W
E
I
P
R
E
S
L
K
L
E
-
K
-
K
L
G
A
G
Q
F
G
E
V
W
-----
M
A
T
Y
N
-
K
-
H
T
K
V
A
V
K
T
M
K
P
-----------
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
-
E
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
E
-
G
S
K
Q
P
L
P
K
-
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
----------------------
P
I
K
W
T
A
P
E
A
I
N
F
---
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
T
A
T
E
S
Q
Y
E
E
I
-------------------------------------------------------------------------------------------
85
PsiBlast_CBE
60.35
42%
-99
- C2 -
3VRY
1
HCK_HUMAN
A:
[174-448]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
Q
K
P
W
E
K
D
A
W
E
I
P
R
E
S
L
K
L
E
-
K
-
K
L
G
A
G
Q
F
G
E
V
W
-----
M
A
T
Y
N
-
K
-
H
T
K
V
A
V
K
T
M
K
P
G
S
-
M
S
V
E
A
--
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
-
E
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
E
-
G
S
K
Q
P
L
P
K
-
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
---------------------
F
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
T
A
T
E
S
Q
Y
E
E
I
P
------------------------------------------------------------------------------------------
83
PsiBlast_CBE
60.28
42%
-97
- C2 -
3VRZ
1
HCK_HUMAN
A:
[174-448]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
Q
K
P
W
E
K
D
A
W
E
I
P
R
E
S
L
K
L
E
-
K
-
K
L
G
A
G
Q
F
G
E
V
W
-----
M
A
T
Y
N
-
K
-
H
T
K
V
A
V
K
T
M
K
P
G
S
-
M
S
V
E
A
--
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
-
E
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
E
-
G
S
K
Q
P
L
P
K
-
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
----------------------
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
T
A
T
E
S
Q
Y
E
E
I
P
------------------------------------------------------------------------------------------
79
PsiBlast_CBE
60.28
42%
-94
- C2 -
3VS1
1
HCK_HUMAN
A:
[174-448]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
Q
K
P
W
E
K
D
A
W
E
I
P
R
E
S
L
K
L
E
-
K
-
K
L
G
A
G
Q
F
G
E
V
W
-----
M
A
T
Y
N
-
K
-
H
T
K
V
A
V
K
T
M
K
P
G
S
-
M
S
V
E
A
--
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
-
E
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
E
-
G
S
K
Q
P
L
P
K
-
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
----------------------
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
T
A
T
E
S
Q
Y
E
E
I
P
------------------------------------------------------------------------------------------
92
PsiBlast_CBE
60.27
42%
-95
- C2 -
1QCF
1
HCK_HUMAN
A:
[174-448]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
Q
K
P
W
E
K
D
A
W
E
I
P
R
E
S
L
K
L
E
-
K
-
K
L
G
A
G
Q
F
G
E
V
W
-----
M
A
T
Y
N
-
K
-
H
T
K
V
A
V
K
T
M
K
P
G
S
-
M
S
V
E
A
--
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
-
E
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
E
-
G
S
K
Q
P
L
P
K
-
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
E
D
---
N
---
E
Y
T
-
A
R
E
G
A
--
K
F
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
T
A
T
E
S
Q
Y
E
E
I
P
------------------------------------------------------------------------------------------
90
PsiBlast_CBE
60.23
42%
-99
- C2 -
2C0I
1
HCK_HUMAN
B:
[174-448]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
Q
K
P
W
E
K
D
A
W
E
I
P
R
E
S
L
K
L
E
-
K
-
K
L
G
A
G
Q
F
G
E
V
W
-----
M
A
T
Y
N
-
K
-
H
T
K
V
A
V
K
T
M
K
P
G
S
-
M
S
V
E
A
--
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
-
E
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
E
-
G
S
K
Q
P
L
P
K
-
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
----------------------
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
T
A
T
E
S
Q
Y
E
E
I
P
------------------------------------------------------------------------------------------
97
PsiBlast_CBE
60.17
42%
-96
- C2 -
2ZV8
1
LYN_MOUSE
A:
[8-268]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
P
R
E
S
I
K
L
V
-
K
-
K
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
N
N
S
T
-------
K
V
A
V
K
T
L
K
P
G
T
-
M
S
V
Q
A
--
F
L
E
E
A
N
L
M
K
T
L
Q
H
D
K
L
V
R
L
Y
A
V
V
T
K
E
E
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
E
-
G
G
K
V
L
L
P
K
-
L
I
D
F
S
A
Q
I
A
E
G
M
A
Y
I
E
R
K
N
Y
I
H
R
D
L
R
A
A
N
V
L
V
S
E
S
L
M
C
K
I
A
D
F
G
L
A
R
V
I
--------------R
E
G
A
--
K
F
P
I
K
W
T
A
P
E
A
I
N
F
G
C
F
T
I
K
S
N
V
W
S
F
G
I
L
L
Y
E
I
V
T
Y
G
K
I
P
Y
P
G
R
T
N
A
D
V
M
S
A
L
S
Q
G
Y
R
M
P
R
M
E
N
C
P
D
E
L
Y
D
I
M
K
M
C
W
K
E
K
A
E
E
R
P
T
F
D
Y
L
Q
S
V
L
D
D
F
Y
-----------------------------------------------------------------------------------------------------
84
PsiBlast_CBE
60.16
42%
-98
- C2 -
3VRY
1
HCK_HUMAN
B:
[174-448]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
Q
K
P
W
E
K
D
A
W
E
I
P
R
E
S
L
K
L
E
-
K
-
K
L
G
A
G
Q
F
G
E
V
W
-----
M
A
T
Y
N
-
K
-
H
T
K
V
A
V
K
T
M
K
P
G
S
-
M
S
V
E
A
--
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
-
E
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
E
-
G
S
K
Q
P
L
P
K
-
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
---------------------
F
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
T
A
T
E
S
Q
Y
E
E
I
P
------------------------------------------------------------------------------------------
80
PsiBlast_CBE
60.10
42%
-99
- C2 -
3VS0
1
HCK_HUMAN
B:
[174-448]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
Q
K
P
W
E
K
D
A
W
E
I
P
R
E
S
L
K
L
E
-
K
-
K
L
G
A
G
Q
F
G
E
V
W
-----
M
A
T
Y
N
-
K
-
H
T
K
V
A
V
K
T
M
K
P
G
S
-
M
S
V
E
A
--
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
-
E
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
E
-
G
S
K
Q
P
L
P
K
-
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
----------------------
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
T
A
T
E
S
Q
Y
E
E
I
P
------------------------------------------------------------------------------------------
77
PsiBlast_CBE
60.01
42%
-103
- C2 -
3VS2
1
HCK_HUMAN
A:
[174-448]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
Q
K
P
W
E
K
D
A
W
E
I
P
R
E
S
L
K
L
E
-
K
-
K
L
G
A
G
Q
F
G
E
V
W
-----
M
A
T
Y
N
-
K
-
H
T
K
V
A
V
K
T
M
K
P
G
S
-
M
S
V
E
A
--
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
-
E
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
E
-
G
S
K
Q
P
L
P
K
-
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
----------------------
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
T
A
T
E
S
Q
Y
E
E
I
P
------------------------------------------------------------------------------------------
75
PsiBlast_CBE
60.01
42%
-99
- C2 -
3VS3
1
HCK_HUMAN
A:
[174-448]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
Q
K
P
W
E
K
D
A
W
E
I
P
R
E
S
L
K
L
E
-
K
-
K
L
G
A
G
Q
F
G
E
V
W
-----
M
A
T
Y
N
-
K
-
H
T
K
V
A
V
K
T
M
K
P
G
S
-
M
S
V
E
A
--
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
-
E
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
E
-
G
S
K
Q
P
L
P
K
-
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
---------------------
F
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
T
A
T
E
S
Q
Y
E
E
I
P
------------------------------------------------------------------------------------------
68
PsiBlast_CBE
59.99
42%
-99
- C2 -
3VS6
1
HCK_HUMAN
B:
[174-448]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
Q
K
P
W
E
K
D
A
W
E
I
P
R
E
S
L
K
L
E
-
K
-
K
L
G
A
G
Q
F
G
E
V
W
-----
M
A
T
Y
N
-
K
-
H
T
K
V
A
V
K
T
M
K
P
G
S
-
M
S
V
E
A
--
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
-
E
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
E
-
G
S
K
Q
P
L
P
K
-
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
---------------------
F
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
T
A
T
E
S
Q
Y
E
E
I
P
------------------------------------------------------------------------------------------
76
PsiBlast_CBE
59.98
42%
-99
- C2 -
3VS2
1
HCK_HUMAN
B:
[174-448]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
Q
K
P
W
E
K
D
A
W
E
I
P
R
E
S
L
K
L
E
-
K
-
K
L
G
A
G
Q
F
G
E
V
W
-----
M
A
T
Y
N
-
K
-
H
T
K
V
A
V
K
T
M
K
P
G
S
-
M
S
V
E
A
--
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
-
E
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
E
-
G
S
K
Q
P
L
P
K
-
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
----------------------
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
T
A
T
E
S
Q
Y
E
E
I
P
------------------------------------------------------------------------------------------
88
PsiBlast_CBE
59.75
42%
-100
- C2 -
2C0O
1
HCK_HUMAN
B:
[174-448]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
Q
K
P
W
E
K
D
A
W
E
I
P
R
E
S
L
K
L
E
-
K
-
K
L
G
A
G
Q
F
G
E
V
W
-----
M
A
T
Y
N
-
K
-
H
T
K
V
A
V
K
T
M
K
P
G
S
-
M
S
V
E
A
--
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
-
E
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
E
-
G
S
K
Q
P
L
P
K
-
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
----------------------
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
T
A
T
E
S
Q
Y
E
E
I
P
------------------------------------------------------------------------------------------
95
PsiBlast_CBE
59.69
42%
-94
- C2 -
2ZVA
1
LYN_MOUSE
A:
[8-269]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
P
R
E
S
I
K
L
V
-
K
-
K
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
N
N
S
T
-------
K
V
A
V
K
T
L
K
P
G
T
-
M
S
V
Q
A
--
F
L
E
E
A
N
L
M
K
T
L
Q
H
D
K
L
V
R
L
Y
A
V
V
T
K
E
E
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
E
-
G
G
K
V
L
L
P
K
-
L
I
D
F
S
A
Q
I
A
E
G
M
A
Y
I
E
R
K
N
Y
I
H
R
D
L
R
A
A
N
V
L
V
S
E
S
L
M
C
K
I
A
D
F
G
L
A
R
V
I
E
----------
T
-
A
R
E
G
A
--
K
F
P
I
K
W
T
A
P
E
A
I
N
F
G
C
F
T
I
K
S
N
V
W
S
F
G
I
L
L
Y
E
I
V
T
Y
G
K
I
P
Y
P
G
R
T
N
A
D
V
M
S
A
L
S
Q
G
Y
R
M
P
R
M
E
N
C
P
D
E
L
Y
D
I
M
K
M
C
W
K
E
K
A
E
E
R
P
T
F
D
Y
L
Q
S
V
L
D
D
F
Y
T
----------------------------------------------------------------------------------------------------
78
PsiBlast_CBE
59.66
42%
-103
- C2 -
3VS1
1
HCK_HUMAN
B:
[174-448]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
Q
K
P
W
E
K
D
A
W
E
I
P
R
E
S
L
K
L
E
-
K
-
K
L
G
A
G
Q
F
G
E
V
W
-----
M
A
T
Y
N
-
K
-
H
T
K
V
A
V
K
T
M
K
P
G
S
-
M
S
V
E
A
--
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
-
E
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
E
-
G
S
K
Q
P
L
P
K
-
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
----------------------
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
T
A
T
E
S
Q
Y
E
E
I
P
------------------------------------------------------------------------------------------
66
PsiBlast_CBE
59.66
42%
-102
- C2 -
4LUD
1
HCK_HUMAN
A:
[174-448]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
Q
K
P
W
E
K
D
A
W
E
I
P
R
E
S
L
K
L
E
-
K
-
K
L
G
A
G
Q
F
G
E
V
W
-----
M
A
T
Y
N
-
K
-
H
T
K
V
A
V
K
T
M
K
P
----
S
V
E
A
--
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
-
E
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
E
-
G
S
K
Q
P
L
P
K
-
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
----------------------
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
N
P
E
----
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
T
A
T
E
S
Q
Y
E
E
I
P
------------------------------------------------------------------------------------------
102
PsiBlast_CBE
59.65
41%
-88
- C2 -
1Y57
1
SRC_HUMAN
A:
[115-436]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
L
N
V
K
H
Y
K
I
R
K
L
D
S
G
G
F
Y
I
T
S
R
T
Q
F
N
S
L
Q
Q
L
V
--
A
Y
Y
S
K
H
A
D
G
L
C
H
R
L
T
T
V
C
P
-
T
S
K
P
Q
T
Q
G
L
A
K
D
A
W
E
I
P
R
E
S
L
R
L
E
-
V
-
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
G
T
T
R
-------
V
A
I
K
T
L
K
P
G
T
-
M
S
P
E
--
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
-
E
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
T
-
G
K
Y
L
R
L
P
Q
-
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
E
D
---
N
---
E
Y
T
-
A
R
Q
G
A
--
K
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
P
G
E
N
L
----------------------------------------------------------------------------------------
61
PsiBlast_CBE
59.34
45%
-97
- C2 -
4UEU
1
?
A:
[7-268]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
P
R
S
E
I
T
L
E
-
R
-
K
L
G
S
G
Q
F
G
E
V
Y
E
G
K
W
R
N
Y
N
------
I
E
V
A
V
K
T
L
K
E
G
T
-
M
S
V
E
--
E
F
L
Q
E
A
Q
I
M
K
K
L
K
H
P
N
L
V
Q
L
Y
G
V
C
T
K
E
P
P
I
Y
I
I
T
E
Y
M
S
H
G
S
L
L
D
Y
L
R
D
C
E
-
G
H
T
V
N
A
-
Q
A
L
L
D
M
A
A
Q
V
A
S
G
M
A
Y
L
E
S
Q
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
N
V
V
K
V
A
D
F
G
L
A
R
L
I
-----------------
A
--
K
F
P
I
K
W
T
A
P
E
A
I
S
Y
N
R
F
S
I
K
S
D
V
W
A
F
G
I
L
L
W
E
I
F
T
Y
G
Q
V
P
Y
P
G
M
S
G
S
E
V
I
E
Q
V
E
R
G
Y
R
M
P
R
P
Q
G
C
P
E
E
I
Y
E
L
M
L
Q
C
W
N
K
S
P
E
E
R
P
T
F
A
E
T
L
H
A
L
E
T
M
F
-----------------------------------------------------------------------------------------------------
104
PsiBlast_CBE
59.24
44%
-99
- C2 -
4MXO
1
SRC_HUMAN
A:
[10-270]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
D
A
W
E
I
P
R
E
S
L
R
L
E
-
V
-
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
G
T
T
R
-------
V
A
I
K
T
L
K
P
G
T
-
M
S
P
E
--
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
-
E
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
T
-
G
K
Y
L
R
L
P
Q
-
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
E
--------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
P
G
E
N
L
----------------------------------------------------------------------------------------
105
PsiBlast_CBE
59.01
44%
-99
- C2 -
4MXX
1
SRC_HUMAN
B:
[11-270]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
W
E
I
P
R
E
S
L
R
L
E
-
V
-
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
G
T
T
R
-------
V
A
I
K
T
L
K
P
G
T
-
M
S
P
E
--
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
-
E
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
T
-
G
K
Y
L
R
L
P
Q
-
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
T
D
F
G
L
-------------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
P
G
E
N
L
----------------------------------------------------------------------------------------
103
PsiBlast_CBE
59.00
44%
-94
- C2 -
4MXO
1
SRC_HUMAN
B:
[11-270]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
W
E
I
P
R
E
S
L
R
L
E
-
V
-
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
G
T
T
R
-------
V
A
I
K
T
L
K
P
G
T
-
M
S
P
E
--
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
-
E
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
T
-
G
K
Y
L
R
L
P
Q
-
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
---------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
P
G
E
N
L
----------------------------------------------------------------------------------------
81
PsiBlast_CBE
58.95
42%
-94
- C2 -
3VS0
1
HCK_HUMAN
A:
[174-448]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
Q
K
P
W
E
K
D
A
W
E
I
P
R
E
S
L
K
L
E
-
K
-
K
L
G
A
G
Q
F
G
E
V
W
-----
M
A
T
Y
N
-
K
-
H
T
K
V
A
V
K
T
M
K
P
G
S
-
M
S
V
E
A
--
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
-
E
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
E
-
G
S
K
Q
P
L
P
K
-
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
----------------------
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
T
A
T
E
S
Q
Y
E
E
I
P
------------------------------------------------------------------------------------------
67
PsiBlast_CBE
58.88
42%
-95
- C2 -
3VS7
1
HCK_HUMAN
B:
[174-448]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
Q
K
P
W
E
K
D
A
W
E
I
P
R
E
S
L
K
L
E
-
K
-
K
L
G
A
G
Q
F
G
E
V
W
-----
M
A
T
Y
N
-
K
-
H
T
K
V
A
V
K
T
M
K
P
G
S
-
M
S
V
E
A
--
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
-
E
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
E
-
G
S
K
Q
P
L
P
K
-
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
------------------------
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
T
A
T
E
S
Q
Y
E
E
I
P
------------------------------------------------------------------------------------------
96
PsiBlast_CBE
58.71
42%
-97
- C2 -
2ZV9
1
LYN_MOUSE
A:
[8-268]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
P
R
E
S
I
K
L
V
-
K
-
K
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
N
N
S
T
-------
K
V
A
V
K
T
L
K
P
G
T
-
M
S
V
Q
A
--
F
L
E
E
A
N
L
M
K
T
L
Q
H
D
K
L
V
R
L
Y
A
V
V
T
K
E
E
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
E
-
G
G
K
V
L
L
P
K
-
L
I
D
F
S
A
Q
I
A
E
G
M
A
Y
I
E
R
K
N
Y
I
H
R
D
L
R
A
A
N
V
L
V
S
E
S
L
M
C
K
I
A
D
F
G
L
A
R
V
I
E
---------------
G
A
--
K
F
P
I
K
W
T
A
P
E
A
I
N
F
G
C
F
T
I
K
S
N
V
W
S
F
G
I
L
L
Y
E
I
V
T
Y
G
K
I
P
Y
P
G
R
T
N
A
D
V
M
S
A
L
S
Q
G
Y
R
M
P
R
M
E
N
C
P
D
E
L
Y
D
I
M
K
M
C
W
K
E
K
A
E
E
R
P
T
F
D
Y
L
Q
S
V
L
D
D
F
Y
-----------------------------------------------------------------------------------------------------
99
PsiBlast_CBE
58.58
41%
-99
- C2 -
2HCK
1
HCK_HUMAN
B:
[168-432]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
Q
K
P
W
E
K
D
A
W
E
I
P
R
E
S
L
K
L
E
-
K
-
K
L
G
A
G
Q
F
G
E
V
W
-----
M
A
T
Y
N
-
K
-
H
T
K
V
A
V
K
T
M
K
P
G
S
-
M
S
V
E
A
--
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
-
E
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
E
-
G
S
K
Q
P
L
P
K
-
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
-----------------
G
A
--
K
F
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
T
A
T
E
S
Q
Y
Q
Q
Q
P
------------------------------------------------------------------------------------------
94
PsiBlast_CBE
58.42
42%
-95
- C2 -
3A4O
1
LYN_HUMAN
X:
[9-273]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
P
R
E
S
I
K
L
V
-
K
-
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
N
N
S
T
-------
K
V
A
V
K
T
L
K
P
G
T
-
M
S
V
Q
A
--
F
L
E
E
A
N
L
M
K
T
L
Q
H
D
K
L
V
R
L
Y
A
V
V
T
R
E
E
P
I
Y
I
I
T
E
Y
M
A
K
G
S
L
L
D
F
L
K
S
D
E
-
G
G
K
V
L
L
P
K
-
L
I
D
F
S
A
Q
I
A
E
G
M
A
Y
I
E
R
K
N
Y
I
H
R
D
L
R
A
A
N
V
L
V
S
E
S
L
M
C
K
I
A
D
F
G
L
A
R
V
----------------
E
G
A
--
K
F
P
I
K
W
T
A
P
E
A
I
N
F
G
C
F
T
I
K
S
D
V
W
S
F
G
I
L
L
Y
E
I
V
T
Y
G
K
I
P
Y
P
G
R
T
N
A
D
V
M
T
A
L
S
Q
G
Y
R
M
P
R
V
E
N
C
P
D
E
L
Y
D
I
M
K
M
C
W
K
E
K
A
E
E
R
P
T
F
D
Y
L
Q
S
V
L
D
D
F
Y
T
A
T
E
-------------------------------------------------------------------------------------------------
100
PsiBlast_CBE
57.54
41%
-100
- C2 -
1AD5
1
HCK_HUMAN
B:
[168-432]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
Q
K
P
W
E
K
D
A
W
E
I
P
R
E
S
L
K
L
E
-
K
-
K
L
G
A
G
Q
F
G
E
V
W
-----
M
A
T
Y
N
-
K
-
H
T
K
V
A
V
K
T
M
K
P
G
S
-
M
S
V
E
A
--
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
-
E
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
E
-
G
S
K
Q
P
L
P
K
-
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
-----------------
G
A
--
K
F
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
T
A
T
E
S
Q
Y
Q
Q
Q
P
------------------------------------------------------------------------------------------
127
HHSearch
56.31
41%
-100
- C2 -
3CBL
3
A:
[108-374]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
V
L
N
H
E
D
L
V
L
G
-
E
-
Q
I
G
R
G
N
F
G
E
V
F
S
G
R
L
R
A
D
------
N
T
L
V
A
V
K
S
C
R
E
T
L
-
P
P
D
L
K
A
K
F
L
Q
E
A
R
I
L
K
Q
Y
S
H
P
N
I
V
R
L
I
G
V
C
T
Q
K
Q
P
I
Y
I
V
M
E
L
V
Q
G
G
D
F
L
T
F
L
R
T
E
G
-
A
R
L
R
V
K
-
T
-
L
L
Q
M
V
G
D
A
A
A
G
M
E
Y
L
E
S
K
C
C
I
H
R
D
L
A
A
R
N
C
L
V
T
E
K
N
V
L
K
I
S
D
F
G
M
S
R
E
E
A
D
------
G
V
Y
A
-
A
-
S
G
G
L
R
Q
V
P
V
K
W
T
A
P
E
A
L
N
Y
G
R
Y
S
S
E
S
D
V
W
S
F
G
I
L
L
W
E
T
F
S
L
G
A
S
P
Y
P
N
L
S
N
Q
Q
T
R
E
F
V
E
K
G
G
R
L
P
C
P
E
L
C
P
D
A
V
F
R
L
M
E
Q
C
W
A
Y
E
P
G
Q
R
P
S
F
S
T
I
Y
Q
E
L
Q
S
I
R
K
R
H
--------------------------------------------------------------------------------------------------