@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : EPHA8_HUMAN: (2015-10-07 )
MAPARGRLPPALWVVTAAAAAATCVSAARGEVNLLDTSTIHGDWGWLTYPAHGWDSINEVDESFQPIHTYQVCNVMSPNQNNWLRTSWVPRDGARRVYAEIKFTLRDCNSMPGVLGTCKETFNLYYLESDRDLGASTQESQFLKIDTIAADESFTGADLGVRRLKLNTEVRSVGPLSKRGFYLAFQDIGACLAILSLRIYYKKCPAMVRNLAAFSEAVTGADSSSLVEVRGQCVRHSEERDTPKMYCSAEGEWLVPIGKCVCSAGYEERRDACVACELGFYKSAPGDQLCARCPPHSHSAAPAAQACHCDLSYYRAALDPPSSACTRPPSAPVNLISSVNGTSVTLEWAPPLDPGGRSDITYNAVCRRCPWALSRCEACGSGTRFVPQQTSLVQASLLVANLLAHMNYSFWIEAVNGVSDLSPEPRRAAVVNITTNQAAPSQVVVIRQERAGQTSVSLLWQEPEQPNGIILEYEIKYYEKDKEMQSYSTLKAVTTRATVSGLKPGTRYVFQVRARTSAGCGRFSQAMEVETGKPRPRYDTRTIVWICLTLITGLVVLLLLLICKKRHCGYSKAFQDSDEEKMHYQNGQAPPPVFLPLHHPPGKLPEPQFYAEPHTYEEPGRAGRSFTREIEASRIHIEKIIGSGDSGEVCYGRLRVPGQRDVPVAIKALKAGYTERQRRDFLSEASIMGQFDHPNIIRLEGVVTRGRLAMIVTEYMENGSLDTFLRTHDGQFTIMQLVGMLRGVGAGMRYLSDLGYVHRDLAARNVLVDSNLVCKVSDFGLSRVLEDDPDAAYTTTGGKIPIRWTAPEAIAFRTFSSASDVWSFGVVMWEVLAYGERPYWNMTNRDVISSVEEGYRLPAPMGCPHALHQLMLDCWHKDRAQRPRFSQIVSVLDALIRSPESLRATATVSRCPPPAFVRSCFDLRGGSGGGGGLTVGDWLDSIRMGRYRDHFAAGGYSSLGMVLRMNAQDVRALGITLMGHQKKILGSIQTMRAQLTSTQGPRRHL
Atome Classification :
(69 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650...-....660.......670.......680.......690.......700.......710.......720.....--..730....-...740.......750.......760.......770.......780.......790....--...800.......810.......820.......830.......840.-......850.......860.......870.......880.......890.......900.......910.....-..920.......930.......940.......950.......960.......970.......980.......990.......1000..
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MAPARGRLP
P
A
L
W
V
V
T
A
A
A
A
A
A
T
C
V
S
AARG
E
V
N
L
L
D
TSTIHGDWG
W
L
TYPAHGWD
S
I
N
E
V
D
E
SFQP
I
H
T
Y
Q
V
C
NVMSPNQNN
W
L
R
TSWVPRDGA
R
R
V
Y
A
E
I
K
F
T
L
R
D
CNSMPG
V
L
G
T
C
K
E
T
F
N
L
Y
Y
LESDRDLGASTQES
Q
F
L
K
I
D
T
I
AADESFTGADL
G
V
R
R
L
K
LNTEVRSVGPLSKR
G
F
Y
L
A
F
Q
D
I
G
A
C
L
A
I
L
S
L
R
I
Y
Y
K
K
C
P
A
M
V
R
N
L
A
A
F
S
E
A
VTGADS
S
S
L
V
E
V
R
G
Q
C
V
RHSEERDTP
K
M
Y
CSAEG
E
W
L
V
P
I
G
K
C
V
CSA
G
Y
E
E
RRD
A
C
V
A
C
ELGFYKSAPGD
Q
L
C
A
RCPPHSHSAAP
A
A
Q
ACHC
D
L
S
Y
Y
R
AALDPPSSACTRPPSA
P
V
N
L
ISSVNG
T
S
V
T
L
E
WAPPLDPGGRS
D
I
T
Y
N
A
V
C
R
RC
P
W
A
L
S
R
C
E
ACGSGTRFVPQ
Q
T
S
L
V
Q
A
S
L
L
V
A
N
L
L
A
HMN
Y
S
F
W
I
E
AVNGVSDLSPEPR
R
A
A
V
V
N
I
TTNQAAP
S
Q
V
V
V
I
R
QERAGQ
T
S
V
S
L
L
WQEPEQPN
G
I
I
L
E
Y
E
I
K
Y
Y
EK
D
K
E
M
Q
S
Y
S
T
L
K
A
V
T
TRATVSGLKPG
T
R
Y
V
F
Q
V
RARTSAGCGR
F
S
Q
A
M
EVETGKPRPRYDT
R
T
I
V
W
I
C
L
T
L
I
T
G
L
V
V
L
L
L
L
L
I
CKKRHCGYSKAFQDSDE
E
K
MHYQNGQAPP
P
V
F
L
PLHHPPGKLPEPQFYAEPHTYEEPGRAG
R
S
F
T
R
E
IEAS
R
I
H
I
E
K
IIGSGDSG
E
V
C
Y
G
R
LR-VPGQRDV
P
V
A
I
K
A
L
KAG
Y
T
E
R
Q
R
R
D
F
L
S
E
A
S
IMGQFDHP
N
I
I
R
L
E
G
V
VTR
G
R
L
A
M
I
V
T
E
Y
M
ENGSL
D
T
F
L
RT--HDGQ
F
T
I
M
Q
-
L
V
G
M
L
R
G
V
G
A
G
M
R
Y
L
S
D
L
G
Y
V
H
R
D
L
A
AR
N
V
L
VDSN
L
V
C
K
VSDF
G
L
S
R
V
LEDDPDAAYTTT--G
G
K
I
P
I
R
WTAP
E
A
I
A
F
R
TFSS
A
S
D
V
W
S
F
G
V
V
M
W
E
V
L
AYGERPYWNMT-
N
R
D
V
I
S
S
V
E
EGYRLPAPMG
C
P
H
A
L
H
Q
L
M
L
D
C
W
HKDRAQR
P
R
F
S
Q
I
V
S
V
L
D
A
L
IRS
P
E
S
LRA
T
A
TVSRCP
P
P
A
F
V
-
R
S
C
F
DLRGGSGGGGGL
T
V
G
D
W
L
D
S
I
RMGRY
R
D
H
FAAGG
Y
S
S
L
G
M
V
L
RM
N
A
Q
D
V
R
A
L
G
I
T
LMG
H
Q
K
K
I
L
G
S
I
Q
T
M
R
A
Q
LTSTQGPRRHL
1
PsiBlast_PDB
83.15
100%
-112
- C3 -
3KUL
2
EPHA8_HUMAN
A:
[43-316]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
R
E
I
E
A
S
R
I
H
I
E
K
I
I
G
S
G
D
S
G
E
V
C
Y
G
R
L
R
-
V
P
G
Q
R
D
V
P
V
A
I
K
A
L
K
A
G
Y
T
E
R
Q
R
R
D
F
L
S
E
A
S
I
M
G
Q
F
D
H
P
N
I
I
R
L
E
G
V
V
T
R
G
R
L
A
M
I
V
T
E
Y
M
E
N
G
S
L
D
T
F
L
R
T
--
H
D
G
Q
F
T
I
M
Q
-
L
V
G
M
L
R
G
V
G
A
G
M
R
Y
L
S
D
L
G
Y
V
H
R
D
L
A
A
R
N
V
L
V
D
S
N
L
V
C
K
V
S
D
F
G
L
S
R
V
L
E
----
A
A
Y
T
T
T
-----
I
P
I
R
W
T
A
P
E
A
I
A
F
R
T
F
S
S
A
S
D
V
W
S
F
G
V
V
M
W
E
V
L
A
Y
G
E
R
P
Y
W
N
M
T
-
N
R
D
V
I
S
S
V
E
E
G
Y
R
L
P
A
P
M
G
C
P
H
A
L
H
Q
L
M
L
D
C
W
H
K
D
R
A
Q
R
P
R
F
S
Q
I
V
S
V
L
D
A
L
I
R
S
P
E
----------------------------------------------------------------------------------------------------------
33
PsiBlast_CBE
79.36
73%
-117
- C3 -
2Y6O
1
A:
[4-286]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
R
E
F
A
K
E
I
D
A
S
C
I
K
I
E
K
V
I
G
V
G
E
F
G
E
V
C
S
G
R
L
K
-
V
P
G
K
R
E
I
C
V
A
I
K
T
L
K
A
G
Y
T
D
K
Q
R
R
D
F
L
S
E
A
S
I
M
G
Q
F
D
H
P
N
I
I
H
L
E
G
V
V
T
K
C
K
P
V
M
I
I
T
E
Y
M
E
N
G
S
L
D
A
F
L
R
K
--
N
D
G
R
F
T
V
I
Q
-
L
V
G
M
L
R
G
I
G
S
G
M
K
Y
L
S
D
M
S
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
----------------------
I
P
I
R
W
T
A
P
E
A
I
A
Y
R
K
F
T
S
A
S
D
V
W
S
Y
G
I
V
M
W
E
V
M
S
Y
G
E
R
P
Y
W
D
M
S
-
N
Q
D
V
I
K
A
I
E
E
G
Y
R
L
P
P
P
M
D
C
P
I
A
L
H
Q
L
M
L
D
C
W
Q
K
E
R
S
D
R
P
K
F
G
Q
I
V
N
M
L
D
K
L
I
R
N
P
N
S
L
K
R
T
-----------------------------------------------------------------------------------------------------
34
PsiBlast_CBE
79.22
73%
-113
- C3 -
2Y6M
3
A:
[4-286]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
R
E
F
A
K
E
I
D
A
S
C
I
K
I
E
K
V
I
G
V
G
E
F
G
E
V
C
S
G
R
L
K
-
V
P
G
K
R
E
I
C
V
A
I
K
T
L
K
A
G
Y
T
D
K
Q
R
R
D
F
L
S
E
A
S
I
M
G
Q
F
D
H
P
N
I
I
H
L
E
G
V
V
T
K
C
K
P
V
M
I
I
T
E
Y
M
E
N
G
S
L
D
A
F
L
R
K
--
N
D
G
R
F
T
V
I
Q
-
L
V
G
M
L
R
G
I
G
S
G
M
K
Y
L
S
D
M
S
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
-----------------------
P
I
R
W
T
A
P
E
A
I
A
Y
R
K
F
T
S
A
S
D
V
W
S
Y
G
I
V
M
W
E
V
M
S
Y
G
E
R
P
Y
W
D
M
S
-
N
Q
D
V
I
K
A
I
E
E
G
Y
R
L
P
P
P
M
D
C
P
I
A
L
H
Q
L
M
L
D
C
W
Q
K
E
R
S
D
R
P
K
F
G
Q
I
V
N
M
L
D
K
L
I
R
N
P
N
S
L
K
R
T
-----------------------------------------------------------------------------------------------------
24
PsiBlast_CBE
78.55
62%
-113
- C3 -
2QOC
2
A:
[10-303]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
K
E
L
D
A
T
N
I
S
I
D
K
V
V
G
A
G
E
F
G
E
V
C
S
G
R
L
K
-
L
P
S
K
K
E
I
S
V
A
I
K
T
L
K
V
G
Y
T
E
K
Q
R
R
D
F
L
G
E
A
S
I
M
G
Q
F
D
H
P
N
I
I
R
L
E
G
V
V
T
K
S
K
P
V
M
I
V
T
E
Y
M
E
N
G
S
L
D
S
F
L
R
K
--
H
D
A
Q
F
T
V
I
Q
-
L
V
G
M
L
R
G
I
A
S
G
M
K
Y
L
S
D
M
G
Y
V
H
R
D
L
A
A
R
N
I
L
I
N
S
N
L
V
C
K
V
S
D
F
G
L
S
R
V
L
E
D
-------------
K
I
P
I
R
W
T
S
P
E
A
I
A
Y
R
K
F
T
S
A
S
D
V
W
S
Y
G
I
V
L
W
E
V
M
S
Y
G
E
R
P
Y
W
E
M
S
-
N
Q
D
V
I
K
A
V
D
E
G
Y
R
L
P
P
P
M
D
C
P
A
A
L
Y
Q
L
M
L
D
C
W
Q
K
D
R
N
N
R
P
K
F
E
Q
I
V
S
I
L
D
K
L
I
R
N
P
G
S
L
K
I
I
T
S
A
A
A
R
P
S
N
L
L
L
D
Q
S
--------------------------------------------------------------------------------------
35
PsiBlast_CBE
78.50
74%
-117
- C3 -
2XYU
7
A:
[1-280]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
A
K
E
I
D
A
S
C
I
K
I
E
K
V
I
G
V
G
E
F
G
E
V
C
S
G
R
L
K
-
V
P
G
K
R
E
I
C
V
A
I
K
T
L
K
A
G
Y
T
D
K
Q
R
R
D
F
L
S
E
A
S
I
M
G
Q
F
D
H
P
N
I
I
H
L
E
G
V
V
T
K
C
K
P
V
M
I
I
T
E
Y
M
E
N
G
S
L
D
A
F
L
R
K
--
N
D
G
R
F
T
V
I
Q
-
L
V
G
M
L
R
G
I
G
S
G
M
K
Y
L
S
D
M
S
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
----------------------
I
P
I
R
W
T
A
P
E
A
I
A
Y
R
K
F
T
S
A
S
D
V
W
S
Y
G
I
V
M
W
E
V
M
S
Y
G
E
R
P
Y
W
D
M
S
-
N
Q
D
V
I
K
A
I
E
E
G
Y
R
L
P
P
P
M
D
C
P
I
A
L
H
Q
L
M
L
D
C
W
Q
K
E
R
S
D
R
P
K
F
G
Q
I
V
N
M
L
D
K
L
I
R
N
P
N
S
L
K
R
T
-----------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
78.17
58%
-110
- C3 -
3FXX
1
A:
[30-328]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
Q
T
V
H
E
F
A
K
E
L
D
A
T
N
I
S
I
D
K
V
V
G
A
G
E
F
G
E
V
C
S
G
R
L
K
-
L
P
S
K
K
E
I
S
V
A
I
K
T
L
K
V
G
Y
T
E
K
Q
R
R
D
F
L
G
E
A
S
I
M
G
Q
F
D
H
P
N
I
I
R
L
E
G
V
V
T
K
S
K
P
V
M
I
V
T
E
Y
M
E
N
G
S
L
D
S
F
L
R
K
--
H
D
A
Q
F
T
V
I
Q
-
L
V
G
M
L
R
G
I
A
S
G
M
K
Y
L
S
D
M
G
Y
V
H
R
D
L
A
A
R
N
I
L
I
N
S
N
L
V
C
K
V
S
D
F
G
L
S
R
V
L
E
D
D
-----------
G
K
I
P
I
R
W
T
S
P
E
A
I
A
Y
R
K
F
T
S
A
S
D
V
W
S
Y
G
I
V
L
W
E
V
M
S
Y
G
E
R
P
Y
W
E
M
S
-
N
Q
D
V
I
K
A
V
D
E
G
Y
R
L
P
P
P
M
D
C
P
A
A
L
Y
Q
L
M
L
D
C
W
Q
K
D
R
N
N
R
P
K
F
E
Q
I
V
S
I
L
D
K
L
I
R
N
P
G
S
L
K
I
I
T
--
A
A
R
P
S
N
L
L
L
D----------------------------------------------------------------------------------------
49
PsiBlast_CBE
77.33
66%
-108
- C3 -
2X9F
1
A:
[11-291]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
E
I
D
V
S
Y
V
K
I
E
E
V
I
G
A
G
E
F
G
E
V
C
R
G
R
L
K
-
A
P
G
K
K
E
S
C
V
A
I
K
T
L
---
Y
T
E
R
Q
R
R
E
F
L
S
E
A
S
I
M
G
Q
F
E
H
P
N
I
I
R
L
E
G
V
V
T
N
S
M
P
V
M
I
L
T
E
F
M
E
N
G
A
L
D
S
F
L
R
L
--
N
D
G
Q
F
T
V
I
Q
-
L
V
G
M
L
R
G
I
A
S
G
M
R
Y
L
A
E
M
S
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
S
R
F
L
-------------
G
G
K
I
P
I
R
W
T
A
P
E
A
I
A
F
R
K
F
T
S
A
S
D
A
W
S
Y
G
I
V
M
W
E
V
M
S
F
G
E
R
P
Y
W
D
M
S
-
N
Q
D
V
I
N
A
I
E
Q
D
Y
R
L
P
P
P
P
D
C
P
T
S
L
H
Q
L
M
L
D
C
W
Q
K
D
R
N
A
R
P
R
F
P
Q
V
V
S
A
L
D
K
M
I
R
N
P
A
S
L
K
I
V
A
----------------------------------------------------------------------------------------------------
32
PsiBlast_CBE
77.32
62%
-118
- C3 -
3DZQ
1
A:
[26-318]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
A
K
E
L
D
A
T
N
I
S
I
D
K
V
V
G
A
G
E
F
G
E
V
C
S
G
R
L
K
-
L
P
S
K
K
E
I
S
V
A
I
K
T
L
K
V
G
Y
T
E
K
Q
R
R
D
F
L
G
E
A
S
I
M
G
Q
F
D
H
P
N
I
I
R
L
E
G
V
V
T
K
S
K
P
V
M
I
V
T
E
Y
M
E
N
G
S
L
D
S
F
L
R
K
--
H
D
A
Q
F
T
V
I
Q
-
L
V
G
M
L
R
G
I
A
S
G
M
K
Y
L
S
D
M
G
Y
V
H
R
D
L
A
A
R
N
I
L
I
N
S
N
L
V
C
K
V
S
D
F
G
L
---------------------
P
I
R
W
T
S
P
E
A
I
A
Y
R
K
F
T
S
A
S
D
V
W
S
Y
G
I
V
L
W
E
V
M
S
Y
G
E
R
P
Y
W
E
M
S
-
N
Q
D
V
I
K
A
V
D
E
G
Y
R
L
P
P
P
M
D
C
P
A
A
L
Y
Q
L
M
L
D
C
W
Q
K
D
R
N
N
R
P
K
F
E
Q
I
V
S
I
L
D
K
L
I
R
N
P
--
L
K
I
I
T
-------
N
L
L
L
D----------------------------------------------------------------------------------------
31
PsiBlast_CBE
77.29
62%
-113
- C3 -
4G2F
1
A:
[26-317]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
A
K
E
L
D
A
T
N
I
S
I
D
K
V
V
G
A
G
E
F
G
E
V
C
S
G
R
L
K
-
L
P
S
K
K
E
I
S
V
A
I
K
T
L
K
V
G
Y
T
E
K
Q
R
R
D
F
L
G
E
A
S
I
M
G
Q
F
D
H
P
N
I
I
R
L
E
G
V
V
T
K
S
K
P
V
M
I
V
T
E
Y
M
E
N
G
S
L
D
S
F
L
R
K
--
H
D
A
Q
F
T
V
I
Q
-
L
V
G
M
L
R
G
I
A
S
G
M
K
Y
L
S
D
M
G
Y
V
H
R
D
L
A
A
R
N
I
L
I
N
S
N
L
V
C
K
V
S
D
F
G
L
S
R
V
L
-----------------
P
I
R
W
T
S
P
E
A
I
A
Y
R
K
F
T
S
A
S
D
V
W
S
Y
G
I
V
L
W
E
V
M
S
Y
G
E
R
P
Y
W
E
M
S
-
N
Q
D
V
I
K
A
V
D
E
G
Y
R
L
P
P
P
M
D
C
P
A
A
L
Y
Q
L
M
L
D
C
W
Q
K
D
R
N
N
R
P
K
F
E
Q
I
V
S
I
L
D
K
L
I
R
N
P
G
S
L
K
I
I
T
-----
P
S
N
L
L
L
-----------------------------------------------------------------------------------------
9
PsiBlast_PDB
77.19
59%
-111
- C3 -
2QO9
1
A:
[34-330]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
V
H
E
F
A
K
E
L
D
A
T
N
I
S
I
D
K
V
V
G
A
G
E
F
G
E
V
C
S
G
R
L
K
-
L
P
S
K
K
E
I
S
V
A
I
K
T
L
K
V
G
Y
T
E
K
Q
R
R
D
F
L
G
E
A
S
I
M
G
Q
F
D
H
P
N
I
I
R
L
E
G
V
V
T
K
S
K
P
V
M
I
V
T
E
Y
M
E
N
G
S
L
D
S
F
L
R
K
--
H
D
A
Q
F
T
V
I
Q
-
L
V
G
M
L
R
G
I
A
S
G
M
K
Y
L
S
D
M
G
Y
V
H
R
D
L
A
A
R
N
I
L
I
N
S
N
L
V
C
K
V
S
D
F
G
L
S
R
V
L
---------------
K
I
P
I
R
W
T
S
P
E
A
I
A
Y
R
K
F
T
S
A
S
D
V
W
S
Y
G
I
V
L
W
E
V
M
S
Y
G
E
R
P
Y
W
E
M
S
-
N
Q
D
V
I
K
A
V
D
E
G
Y
R
L
P
P
P
M
D
C
P
A
A
L
Y
Q
L
M
L
D
C
W
Q
K
D
R
N
N
R
P
K
F
E
Q
I
V
S
I
L
D
K
L
I
R
N
P
G
S
L
K
I
I
T
-------
N
L
L
L
D----------------------------------------------------------------------------------------
48
PsiBlast_CBE
76.91
66%
-110
- C3 -
2XVD
1
A:
[10-291]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
K
E
I
D
V
S
Y
V
K
I
E
E
V
I
G
A
G
E
F
G
E
V
C
R
G
R
L
K
-
A
P
G
K
K
E
S
C
V
A
I
K
T
L
---
Y
T
E
R
Q
R
R
E
F
L
S
E
A
S
I
M
G
Q
F
E
H
P
N
I
I
R
L
E
G
V
V
T
N
S
M
P
V
M
I
L
T
E
F
M
E
N
G
A
L
D
S
F
L
R
L
--
N
D
G
Q
F
T
V
I
Q
-
L
V
G
M
L
R
G
I
A
S
G
M
R
Y
L
A
E
M
S
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
S
R
F
L
E
---------
S
SL
G
G
K
I
P
I
R
W
T
A
P
E
A
I
A
F
R
K
F
T
S
A
S
D
A
W
S
Y
G
I
V
M
W
E
V
M
S
F
G
E
R
P
Y
W
D
M
S
-
N
Q
D
V
I
N
A
I
E
Q
D
Y
R
L
P
P
P
P
D
C
P
T
S
L
H
Q
L
M
L
D
C
W
Q
K
D
R
N
A
R
P
R
F
P
Q
V
V
S
A
L
D
K
M
I
R
N
P
A
S
L
K
I
V
A
----------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
76.80
71%
-104
- C3 -
3DKO
1
A:
[19-311]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
Y
I
D
P
E
T
Y
E
D
P
N
R
A
V
H
Q
F
A
K
E
L
D
A
S
C
I
K
I
E
R
V
I
G
A
-
E
F
G
E
V
C
S
G
R
L
K
-
L
P
G
K
R
D
V
A
V
A
I
K
T
L
K
V
G
Y
T
E
K
Q
R
R
D
F
L
C
E
A
S
I
M
G
Q
F
D
H
P
N
V
V
H
L
E
G
V
V
T
R
G
K
P
V
M
I
V
I
E
F
M
E
N
G
A
L
D
A
F
L
R
K
--
H
D
G
Q
F
T
V
I
Q
-
L
V
G
M
L
R
G
I
A
A
G
M
R
Y
L
A
D
M
G
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
----------------------
P
V
R
W
T
A
P
E
A
I
Q
Y
R
K
F
T
S
A
S
D
V
W
S
Y
G
I
V
M
W
E
V
M
S
Y
G
E
R
P
Y
W
D
M
S
-
N
Q
D
V
I
K
A
I
E
E
G
Y
R
L
P
A
P
M
D
C
P
A
G
L
H
Q
L
M
L
D
C
W
Q
K
E
R
A
E
R
P
K
F
E
Q
I
V
G
I
L
D
K
M
I
R
N
P
N
S
A
H
H
------------------------------------------------------------------------------------------------------
47
PsiBlast_CBE
76.63
66%
-113
- C3 -
4BB4
1
A:
[9-291]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
A
K
E
I
D
V
S
Y
V
K
I
E
E
V
I
G
A
G
E
F
G
E
V
C
R
G
R
L
K
-
A
P
G
K
K
E
S
C
V
A
I
K
T
L
---
Y
T
E
R
Q
R
R
E
F
L
S
E
A
S
I
M
G
Q
F
E
H
P
N
I
I
R
L
E
G
V
V
T
N
S
M
P
V
M
I
L
T
E
F
M
E
N
G
A
L
D
S
F
L
R
L
--
N
D
G
Q
F
T
V
I
Q
-
L
V
G
M
L
R
G
I
A
S
G
M
R
Y
L
A
E
M
S
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
S
R
F
---------------
G
K
I
P
I
R
W
T
A
P
E
A
I
A
F
R
K
F
T
S
A
S
D
A
W
S
Y
G
I
V
M
W
E
V
M
S
F
G
E
R
P
Y
W
D
M
S
-
N
Q
D
V
I
N
A
I
E
Q
D
Y
R
L
P
P
P
P
D
C
P
T
S
L
H
Q
L
M
L
D
C
W
Q
K
D
R
N
A
R
P
R
F
P
Q
V
V
S
A
L
D
K
M
I
R
N
P
A
S
L
K
I
V
A
----------------------------------------------------------------------------------------------------
26
PsiBlast_CBE
76.31
62%
-114
- C3 -
4TWN
1
A:
[26-318]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
A
K
E
L
D
A
T
N
I
S
I
D
K
V
V
G
A
G
E
F
G
E
V
C
S
G
R
L
K
-
L
P
S
K
K
E
I
S
V
A
I
K
T
L
K
V
G
Y
T
E
K
Q
R
R
D
F
L
G
E
A
S
I
M
G
Q
F
D
H
P
N
I
I
R
L
E
G
V
V
T
K
S
K
P
V
M
I
V
T
E
Y
M
E
N
G
S
L
D
S
F
L
R
K
--
H
D
A
Q
F
T
V
I
Q
-
L
V
G
M
L
R
G
I
A
S
G
M
K
Y
L
S
D
M
G
Y
V
H
R
D
L
A
A
R
N
I
L
I
N
S
N
L
V
C
K
V
S
D
F
G
L
S
R
-----------------
K
I
P
I
R
W
T
S
P
E
A
I
A
Y
R
K
F
T
S
A
S
D
V
W
S
Y
G
I
V
L
W
E
V
M
S
Y
G
E
R
P
Y
W
E
M
S
-
N
Q
D
V
I
K
A
V
D
E
G
Y
R
L
P
P
P
M
D
C
P
A
A
L
Y
Q
L
M
L
D
C
W
Q
K
D
R
N
N
R
P
K
F
E
Q
I
V
S
I
L
D
K
L
I
R
N
P
G
S
L
K
I
I
T
------
S
N
L
L
L
D----------------------------------------------------------------------------------------
53
PsiBlast_CBE
76.14
66%
-106
- C3 -
2VWY
1
A:
[11-291]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
E
I
D
V
S
Y
V
K
I
E
E
V
I
G
A
G
E
F
G
E
V
C
R
G
R
L
K
-
A
P
G
K
K
E
S
C
V
A
I
K
T
L
K
G
G
Y
T
E
R
Q
R
R
E
F
L
S
E
A
S
I
M
G
Q
F
E
H
P
N
I
I
R
L
E
G
V
V
T
N
S
M
P
V
M
I
L
T
E
F
M
E
N
G
A
L
D
S
F
L
R
L
--
N
D
G
Q
F
T
V
I
Q
-
L
V
G
M
L
R
G
I
A
S
G
M
R
Y
L
A
E
M
S
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
S
R
F
L
E
E
N
S
S
D
-------
G
G
K
I
P
I
R
W
T
A
P
E
A
I
A
F
R
K
F
T
S
A
S
D
A
W
S
Y
G
I
V
M
W
E
V
M
S
F
G
E
R
P
Y
W
D
M
S
-
N
Q
D
V
I
N
A
I
E
Q
D
Y
R
L
P
P
P
P
D
C
P
T
S
L
H
Q
L
M
L
D
C
W
Q
K
D
R
N
A
R
P
R
F
P
Q
V
V
S
A
L
D
K
M
I
R
N
P
A
S
L
K
I
V
A
----------------------------------------------------------------------------------------------------
27
PsiBlast_CBE
76.07
62%
-115
- C3 -
4P4C
1
A:
[27-318]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
K
E
L
D
A
T
N
I
S
I
D
K
V
V
G
A
G
E
F
G
E
V
C
S
G
R
L
K
-
L
P
S
K
K
E
I
S
V
A
I
K
T
L
K
V
G
Y
T
E
K
Q
R
R
D
F
L
G
E
A
S
I
M
G
Q
F
D
H
P
N
I
I
R
L
E
G
V
V
T
K
S
K
P
V
M
I
V
T
E
Y
M
E
N
G
S
L
D
S
F
L
R
K
--
H
D
A
Q
F
T
V
I
Q
-
L
V
G
M
L
R
G
I
A
S
G
M
K
Y
L
S
D
M
G
Y
V
H
R
D
L
A
A
R
N
I
L
I
N
S
N
L
V
C
K
V
S
D
F
-----------------------
P
I
R
W
T
S
P
E
A
I
A
Y
R
K
F
T
S
A
S
D
V
W
S
Y
G
I
V
L
W
E
V
M
S
Y
G
E
R
P
Y
W
E
M
S
-
N
Q
D
V
I
K
A
V
D
E
G
Y
R
L
P
P
P
M
D
C
P
A
A
L
Y
Q
L
M
L
D
C
W
Q
K
D
R
N
N
R
P
K
F
E
Q
I
V
S
I
L
D
K
L
I
R
N
P
G
S
L
K
I
I
T
-----
P
S
N
L
L
L
D----------------------------------------------------------------------------------------
50
PsiBlast_CBE
75.93
66%
-108
- C3 -
2VX1
1
A:
[11-291]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
E
I
D
V
S
Y
V
K
I
E
E
V
I
G
A
G
E
F
G
E
V
C
R
G
R
L
K
-
A
P
G
K
K
E
S
C
V
A
I
K
T
L
K
G
G
Y
T
E
R
Q
R
R
E
F
L
S
E
A
S
I
M
G
Q
F
E
H
P
N
I
I
R
L
E
G
V
V
T
N
S
M
P
V
M
I
L
T
E
F
M
E
N
G
A
L
D
S
F
L
R
L
--
N
D
G
Q
F
T
V
I
Q
-
L
V
G
M
L
R
G
I
A
S
G
M
R
Y
L
A
E
M
S
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
S
R
F
L
E
E
N
S
S
D
-------
G
G
K
I
P
I
R
W
T
A
P
E
A
I
A
F
R
K
F
T
S
A
S
D
A
W
S
Y
G
I
V
M
W
E
V
M
S
F
G
E
R
P
Y
W
D
M
S
-
N
Q
D
V
I
N
A
I
E
Q
D
Y
R
L
P
P
P
P
D
C
P
T
S
L
H
Q
L
M
L
D
C
W
Q
K
D
R
N
A
R
P
R
F
P
Q
V
V
S
A
L
D
K
M
I
R
N
P
A
S
L
K
I
V
A
----------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
75.88
58%
-108
- C3 -
2QO7
4
A:
[21-330]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
Y
V
D
P
H
T
-------
V
H
E
F
A
K
E
L
D
A
T
N
I
S
I
D
K
V
V
G
A
G
E
F
G
E
V
C
S
G
R
L
K
-
L
P
S
K
K
E
I
S
V
A
I
K
T
L
K
V
G
Y
T
E
K
Q
R
R
D
F
L
G
E
A
S
I
M
G
Q
F
D
H
P
N
I
I
R
L
E
G
V
V
T
K
S
K
P
V
M
I
V
T
E
Y
M
E
N
G
S
L
D
S
F
L
R
K
--
H
D
A
Q
F
T
V
I
Q
-
L
V
G
M
L
R
G
I
A
S
G
M
K
Y
L
S
D
M
G
Y
V
H
R
D
L
A
A
R
N
I
L
I
N
S
N
L
V
C
K
V
S
D
F
G
----------------------
P
I
R
W
T
S
P
E
A
I
A
Y
R
K
F
T
S
A
S
D
V
W
S
Y
G
I
V
L
W
E
V
M
S
Y
G
E
R
P
Y
W
E
M
S
-
N
Q
D
V
I
K
A
V
D
E
G
Y
R
L
P
P
P
M
D
C
P
A
A
L
Y
Q
L
M
L
D
C
W
Q
K
D
R
N
N
R
P
K
F
E
Q
I
V
S
I
L
D
K
L
I
R
N
P
G
S
L
K
I
I
T
S
----
P
S
N
L
L
L
D----------------------------------------------------------------------------------------
52
PsiBlast_CBE
75.68
66%
-103
- C3 -
2VWZ
1
A:
[11-291]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
E
I
D
V
S
Y
V
K
I
E
E
V
I
G
A
G
E
F
G
E
V
C
R
G
R
L
K
-
A
P
G
K
K
E
S
C
V
A
I
K
T
L
K
G
G
Y
T
E
R
Q
R
R
E
F
L
S
E
A
S
I
M
G
Q
F
E
H
P
N
I
I
R
L
E
G
V
V
T
N
S
M
P
V
M
I
L
T
E
F
M
E
N
G
A
L
D
S
F
L
R
L
--
N
D
G
Q
F
T
V
I
Q
-
L
V
G
M
L
R
G
I
A
S
G
M
R
Y
L
A
E
M
S
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
S
R
F
L
E
E
N
S
S
D
-------
G
G
K
I
P
I
R
W
T
A
P
E
A
I
A
F
R
K
F
T
S
A
S
D
A
W
S
Y
G
I
V
M
W
E
V
M
S
F
G
E
R
P
Y
W
D
M
S
-
N
Q
D
V
I
N
A
I
E
Q
D
Y
R
L
P
P
P
P
D
C
P
T
S
L
H
Q
L
M
L
D
C
W
Q
K
D
R
N
A
R
P
R
F
P
Q
V
V
S
A
L
D
K
M
I
R
N
P
A
S
L
K
I
V
A
----------------------------------------------------------------------------------------------------
54
PsiBlast_CBE
75.61
66%
-106
- C3 -
2VWX
1
A:
[11-291]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
E
I
D
V
S
Y
V
K
I
E
E
V
I
G
A
G
E
F
G
E
V
C
R
G
R
L
K
-
A
P
G
K
K
E
S
C
V
A
I
K
T
L
K
G
G
Y
T
E
R
Q
R
R
E
F
L
S
E
A
S
I
M
G
Q
F
E
H
P
N
I
I
R
L
E
G
V
V
T
N
S
M
P
V
M
I
L
T
E
F
M
E
N
G
A
L
D
S
F
L
R
L
--
N
D
G
Q
F
T
V
I
Q
-
L
V
G
M
L
R
G
I
A
S
G
M
R
Y
L
A
E
M
S
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
S
R
F
L
E
E
N
S
S
D
-------
G
G
K
I
P
I
R
W
T
A
P
E
A
I
A
F
R
K
F
T
S
A
S
D
A
W
S
Y
G
I
V
M
W
E
V
M
S
F
G
E
R
P
Y
W
D
M
S
-
N
Q
D
V
I
N
A
I
E
Q
D
Y
R
L
P
P
P
P
D
C
P
T
S
L
H
Q
L
M
L
D
C
W
Q
K
D
R
N
A
R
P
R
F
P
Q
V
V
S
A
L
D
K
M
I
R
N
P
A
S
L
K
I
V
A
----------------------------------------------------------------------------------------------------
51
PsiBlast_CBE
75.60
66%
-106
- C3 -
2VX0
1
A:
[11-291]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
E
I
D
V
S
Y
V
K
I
E
E
V
I
G
A
G
E
F
G
E
V
C
R
G
R
L
K
-
A
P
G
K
K
E
S
C
V
A
I
K
T
L
K
G
G
Y
T
E
R
Q
R
R
E
F
L
S
E
A
S
I
M
G
Q
F
E
H
P
N
I
I
R
L
E
G
V
V
T
N
S
M
P
V
M
I
L
T
E
F
M
E
N
G
A
L
D
S
F
L
R
L
--
N
D
G
Q
F
T
V
I
Q
-
L
V
G
M
L
R
G
I
A
S
G
M
R
Y
L
A
E
M
S
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
S
R
F
L
E
E
N
S
S
D
--------
G
K
I
P
I
R
W
T
A
P
E
A
I
A
F
R
K
F
T
S
A
S
D
A
W
S
Y
G
I
V
M
W
E
V
M
S
F
G
E
R
P
Y
W
D
M
S
-
N
Q
D
V
I
N
A
I
E
Q
D
Y
R
L
P
P
P
P
D
C
P
T
S
L
H
Q
L
M
L
D
C
W
Q
K
D
R
N
A
R
P
R
F
P
Q
V
V
S
A
L
D
K
M
I
R
N
P
A
S
L
K
I
V
A
----------------------------------------------------------------------------------------------------
55
PsiBlast_CBE
75.48
68%
-109
- C3 -
4AW5
1
A:
[8-289]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
K
E
I
D
V
S
Y
V
K
I
E
E
V
I
G
A
G
E
F
G
E
V
C
R
G
R
L
K
-
A
P
G
K
K
E
S
C
V
A
I
K
T
L
K
G
G
Y
T
E
R
Q
R
R
E
F
L
S
E
A
S
I
M
G
Q
F
E
H
P
N
I
I
R
L
E
G
V
V
T
N
S
M
P
V
M
I
L
T
E
F
M
E
N
G
A
L
D
S
F
L
R
L
--
N
D
G
Q
F
T
V
I
Q
-
L
V
G
M
L
R
G
I
A
S
G
M
R
Y
L
A
E
M
S
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
---------------------
I
P
I
R
W
T
A
P
E
A
I
A
F
R
K
F
T
S
A
S
D
A
W
S
Y
G
I
V
M
W
E
V
M
S
F
G
E
R
P
Y
W
D
M
S
-
N
Q
D
V
I
N
A
I
E
Q
D
Y
R
L
P
P
P
P
D
C
P
T
S
L
H
Q
L
M
L
D
C
W
Q
K
D
R
N
A
R
P
R
F
P
Q
V
V
S
A
L
D
K
M
I
R
N
P
A
S
L
K
I
V
A
----------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
75.48
58%
-110
- C3 -
2QOQ
1
A:
[21-332]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
Y
V
D
P
H
--
E
D
P
T
Q
T
V
H
E
F
A
K
E
L
D
A
T
N
I
S
I
D
K
V
V
G
A
G
E
F
G
E
V
C
S
G
R
L
K
-
L
P
S
K
K
E
I
S
V
A
I
K
T
L
K
V
G
Y
T
E
K
Q
R
R
D
F
L
G
E
A
S
I
M
G
Q
F
D
H
P
N
I
I
R
L
E
G
V
V
T
K
S
K
P
V
M
I
V
T
E
Y
M
E
N
G
S
L
D
S
F
L
R
K
--
H
D
A
Q
F
T
V
I
Q
-
L
V
G
M
L
R
G
I
A
S
G
M
K
Y
L
S
D
M
G
Y
V
H
R
D
L
A
A
R
N
I
L
I
N
S
N
L
V
C
K
V
S
D
F
--------------------
G
K
I
P
I
R
W
T
S
P
E
A
I
A
Y
R
K
F
T
S
A
S
D
V
W
S
Y
G
I
V
L
W
E
V
M
S
Y
G
E
R
P
Y
W
E
M
S
-
N
Q
D
V
I
K
A
V
D
E
G
Y
R
L
P
P
P
M
D
C
P
A
A
L
Y
Q
L
M
L
D
C
W
Q
K
D
R
N
N
R
P
K
F
E
Q
I
V
S
I
L
D
K
L
I
R
N
P
G
S
L
K
I
I
T
-------
N
L
L
L
D
Q
S
--------------------------------------------------------------------------------------
42
PsiBlast_CBE
75.20
69%
-107
- C3 -
2HEN
1
EPHB2_MOUSE
C:
[1-281]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
K
E
I
D
I
S
C
V
K
I
E
Q
V
I
G
A
G
E
F
G
E
V
C
S
G
H
L
K
-
L
P
G
K
R
E
I
F
V
A
I
K
T
L
K
S
G
Y
T
E
K
Q
R
R
D
F
L
S
E
A
S
I
M
G
Q
F
D
H
P
N
V
I
H
L
E
G
V
V
T
K
S
T
P
V
M
I
I
T
E
F
M
E
N
G
S
L
D
S
F
L
R
Q
--
N
D
G
Q
F
T
V
I
Q
-
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
D
M
N
Y
V
H
R
A
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
----------------------
P
I
R
W
T
A
P
E
A
I
Q
Y
R
K
F
T
S
A
S
D
V
W
S
Y
G
I
V
M
W
E
V
M
S
Y
G
E
R
P
Y
W
D
M
T
-
N
Q
D
V
I
N
A
I
E
Q
D
Y
R
L
P
P
P
M
D
C
P
S
A
L
H
Q
L
M
L
D
C
W
Q
K
D
R
N
H
R
P
K
F
G
Q
I
V
N
T
L
D
K
M
I
R
N
P
N
S
L
K
A
M
-----------------------------------------------------------------------------------------------------
43
PsiBlast_CBE
74.91
69%
-110
- C3 -
2HEN
1
EPHB2_MOUSE
B:
[1-281]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
K
E
I
D
I
S
C
V
K
I
E
Q
V
I
G
A
G
E
F
G
E
V
C
S
G
H
L
K
-
L
P
G
K
R
E
I
F
V
A
I
K
T
L
K
S
G
Y
T
E
K
Q
R
R
D
F
L
S
E
A
S
I
M
G
Q
F
D
H
P
N
V
I
H
L
E
G
V
V
T
K
S
T
P
V
M
I
I
T
E
F
M
E
N
G
S
L
D
S
F
L
R
Q
--
N
D
G
Q
F
T
V
I
Q
-
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
D
M
N
Y
V
H
R
A
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
----------------------
P
I
R
W
T
A
P
E
A
I
Q
Y
R
K
F
T
S
A
S
D
V
W
S
Y
G
I
V
M
W
E
V
M
S
Y
G
E
R
P
Y
W
D
M
T
-
N
Q
D
V
I
N
A
I
E
Q
D
Y
R
L
P
P
P
M
D
C
P
S
A
L
H
Q
L
M
L
D
C
W
Q
K
D
R
N
H
R
P
K
F
G
Q
I
V
N
T
L
D
K
M
I
R
N
P
N
S
L
K
A
M
-----------------------------------------------------------------------------------------------------
37
PsiBlast_CBE
74.89
66%
-107
- C3 -
1JPA
1
B:
[8-305]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
I
F
I
D
P
F
T
F
E
D
P
N
E
A
V
R
E
F
A
K
E
I
D
I
S
C
V
K
I
E
Q
V
I
G
A
G
E
F
G
E
V
C
S
G
H
L
-----
K
R
E
I
F
V
A
I
K
T
L
K
S
G
Y
T
E
K
Q
R
R
D
F
L
S
E
A
S
I
M
G
Q
F
D
H
P
N
V
I
H
L
E
G
V
V
T
K
S
-
P
V
M
I
I
T
E
F
M
E
N
G
S
L
D
S
F
L
R
Q
--
N
D
G
Q
F
T
V
I
Q
-
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
D
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
-----------------------
P
I
R
W
T
A
P
E
A
I
Q
Y
R
K
F
T
S
A
S
D
V
W
S
Y
G
I
V
M
W
E
V
M
S
Y
G
E
R
P
Y
W
D
M
T
-
N
-
D
V
I
N
A
I
E
Q
D
Y
R
L
P
P
P
M
D
C
P
S
A
L
H
Q
L
M
L
D
C
W
Q
K
D
R
N
H
R
P
K
F
G
Q
I
V
N
T
L
D
K
M
I
R
N
P
N
S
L
K
-------------------------------------------------------------------------------------------------------
25
PsiBlast_CBE
74.70
62%
-112
- C3 -
4TWO
1
A:
[26-320]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
A
K
E
L
D
A
T
N
I
S
I
D
K
V
V
G
A
G
E
F
G
E
V
C
S
G
R
L
K
-
L
P
S
K
K
E
I
S
V
A
I
K
T
L
K
V
G
Y
T
E
K
Q
R
R
D
F
L
G
E
A
S
I
M
G
Q
F
D
H
P
N
I
I
R
L
E
G
V
V
T
K
S
K
P
V
M
I
V
T
E
Y
M
E
N
G
S
L
D
S
F
L
R
K
--
H
D
A
Q
F
T
V
I
Q
-
L
V
G
M
L
R
G
I
A
S
G
M
K
Y
L
S
D
M
G
Y
V
H
R
D
L
A
A
R
N
I
L
I
N
S
N
L
V
C
K
V
S
D
F
G
L
S
R
V
L
-----------------
P
I
R
W
T
S
P
E
A
I
A
Y
R
K
F
T
S
A
S
D
V
W
S
Y
G
I
V
L
W
E
V
M
S
Y
G
E
R
P
Y
W
E
M
S
-
N
Q
D
V
I
K
A
V
D
E
G
Y
R
L
P
P
P
M
D
C
P
A
A
L
Y
Q
L
M
L
D
C
W
Q
K
D
R
N
N
R
P
K
F
E
Q
I
V
S
I
L
D
K
L
I
R
N
P
G
S
L
K
I
I
T
-----
P
S
N
L
L
L
D
Q
S
--------------------------------------------------------------------------------------
56
PsiBlast_CBE
74.53
64%
-109
- C3 -
1MQB
1
B:
[35-316]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
F
T
T
E
I
H
P
S
C
V
T
R
Q
K
V
I
G
A
G
E
F
G
E
V
Y
K
G
M
L
K
-
T
---
K
E
V
P
V
A
I
K
T
L
K
A
G
Y
T
E
K
Q
R
V
D
F
L
G
E
A
G
I
M
G
Q
F
S
H
H
N
I
I
R
L
E
G
V
I
S
K
Y
K
P
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
E
--
K
D
G
E
F
S
V
L
Q
-
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
S
R
V
L
---------------
K
I
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
L
S
-
N
H
E
V
M
K
A
I
N
D
G
F
R
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
S
I
L
D
K
L
I
R
A
P
D
S
L
K
T
------------------------------------------------------------------------------------------------------
44
PsiBlast_CBE
74.22
69%
-110
- C3 -
2HEN
1
EPHB2_MOUSE
A:
[1-281]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
K
E
I
D
I
S
C
V
K
I
E
Q
V
I
G
A
G
E
F
G
E
V
C
S
G
H
L
K
-
L
P
G
K
R
E
I
F
V
A
I
K
T
L
K
S
G
Y
T
E
K
Q
R
R
D
F
L
S
E
A
S
I
M
G
Q
F
D
H
P
N
V
I
H
L
E
G
V
V
T
K
S
T
P
V
M
I
I
T
E
F
M
E
N
G
S
L
D
S
F
L
R
Q
--
N
D
G
Q
F
T
V
I
Q
-
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
D
M
N
Y
V
H
R
A
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
----------------------
P
I
R
W
T
A
P
E
A
I
Q
Y
R
K
F
T
S
A
S
D
V
W
S
Y
G
I
V
M
W
E
V
M
S
Y
G
E
R
P
Y
W
D
M
T
-
N
Q
D
V
I
N
A
I
E
Q
D
Y
R
L
P
P
P
M
D
C
P
S
A
L
H
Q
L
M
L
D
C
W
Q
K
D
R
N
H
R
P
K
F
G
Q
I
V
N
T
L
D
K
M
I
R
N
P
N
S
L
K
A
M
-----------------------------------------------------------------------------------------------------
45
PsiBlast_CBE
74.00
67%
-111
- C3 -
2YN8
1
B:
[12-294]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
A
K
E
I
D
V
S
Y
V
K
I
E
E
V
I
G
A
G
E
F
G
E
V
C
R
G
R
L
K
-
A
P
G
K
K
E
S
C
V
A
I
K
T
L
K
G
G
Y
T
E
R
Q
R
R
E
F
L
S
E
A
S
I
M
G
Q
F
E
H
P
N
I
I
R
L
E
G
V
V
T
N
S
M
P
V
M
I
L
T
E
F
M
E
N
G
A
L
D
S
F
L
R
L
--
N
D
G
Q
F
T
V
I
Q
-
L
V
G
M
L
R
G
I
A
S
G
M
R
Y
L
A
E
M
S
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
-----------------------
P
I
R
W
T
A
P
E
A
I
A
F
R
K
F
T
S
A
S
D
V
W
S
Y
G
I
V
M
W
E
V
M
S
F
G
E
R
P
Y
W
D
M
S
-
N
Q
D
V
I
N
A
I
E
Q
D
Y
R
L
P
P
P
P
D
C
P
T
S
L
H
Q
L
M
L
D
C
W
Q
K
D
R
N
A
R
P
R
F
P
Q
I
V
S
A
L
D
K
M
I
R
N
P
A
S
L
K
I
V
A
----------------------------------------------------------------------------------------------------
38
PsiBlast_CBE
73.91
66%
-106
- C3 -
1JPA
1
EPHB2_MOUSE
A:
[8-306]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
I
F
I
D
P
F
T
F
E
D
P
N
E
A
V
R
E
F
A
K
E
I
D
I
S
C
V
K
I
E
Q
V
I
G
A
G
E
F
G
E
V
C
S
G
H
L
K
-
L
---
R
E
I
F
V
A
I
K
T
L
K
S
G
Y
T
E
K
Q
R
R
D
F
L
S
E
A
S
I
M
G
Q
F
D
H
P
N
V
I
H
L
E
G
V
V
T
K
S
T
P
V
M
I
I
T
E
F
M
E
N
G
S
L
D
S
F
L
R
Q
--
N
D
G
Q
F
T
V
I
Q
-
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
D
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
-----------------------
P
I
R
W
T
A
P
E
A
I
Q
Y
R
K
F
T
S
A
S
D
V
W
S
Y
G
I
V
M
W
E
V
M
S
Y
G
E
R
P
Y
W
D
M
T
-
N
Q
D
V
I
N
A
I
E
Q
D
Y
R
L
P
P
P
M
D
C
P
S
A
L
H
Q
L
M
L
D
C
W
Q
K
D
R
N
H
R
P
K
F
G
Q
I
V
N
T
L
D
K
M
I
R
N
P
N
S
L
K
A
------------------------------------------------------------------------------------------------------
41
PsiBlast_CBE
73.71
69%
-110
- C3 -
2HEN
1
D:
[1-281]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
K
E
I
D
I
S
C
V
K
I
E
Q
V
I
G
A
G
E
F
G
E
V
C
S
G
H
L
K
-
L
P
G
K
R
E
I
F
V
A
I
K
T
L
K
S
G
Y
T
E
K
Q
R
R
D
F
L
S
E
A
S
I
M
G
Q
F
D
H
P
N
V
I
H
L
E
G
V
V
T
K
S
T
P
V
M
I
I
T
E
F
M
E
N
G
S
L
D
S
F
L
R
Q
--
N
D
G
Q
F
T
V
I
Q
-
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
D
M
N
Y
V
H
R
A
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
----------------------
P
I
R
W
T
A
P
E
A
I
Q
Y
R
K
F
T
S
A
S
D
V
W
S
Y
G
I
V
M
W
E
V
M
S
Y
G
E
R
P
Y
W
D
M
T
-
N
Q
D
V
I
N
A
I
E
Q
D
Y
R
L
P
P
P
M
D
C
P
S
A
L
H
Q
L
M
L
D
C
W
Q
K
D
R
N
H
R
P
K
F
G
Q
I
V
N
T
L
D
K
M
I
R
N
P
N
S
L
K
A
M
-----------------------------------------------------------------------------------------------------
46
PsiBlast_CBE
72.96
67%
-113
- C3 -
2YN8
1
EPHB4_HUMAN
A:
[14-294]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
E
I
D
V
S
Y
V
K
I
E
E
V
I
G
A
G
E
F
G
E
V
C
R
G
R
L
K
------
E
S
C
V
A
I
K
T
L
K
G
G
Y
T
E
R
Q
R
R
E
F
L
S
E
A
S
I
M
G
Q
F
E
H
P
N
I
I
R
L
E
G
V
V
T
N
S
M
P
V
M
I
L
T
E
F
M
E
N
G
A
L
D
S
F
L
R
L
--
N
D
G
Q
F
T
V
I
Q
-
L
V
G
M
L
R
G
I
A
S
G
M
R
Y
L
A
E
M
S
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
-----------------------
P
I
R
W
T
A
P
E
A
I
A
F
R
K
F
T
S
A
S
D
V
W
S
Y
G
I
V
M
W
E
V
M
S
F
G
E
R
P
Y
W
D
M
S
-
N
Q
D
V
I
N
A
I
E
Q
D
Y
R
L
P
P
P
P
D
C
P
T
S
L
H
Q
L
M
L
D
C
W
Q
K
D
R
N
A
R
P
R
F
P
Q
I
V
S
A
L
D
K
M
I
R
N
P
A
S
L
K
I
V
A
----------------------------------------------------------------------------------------------------
57
PsiBlast_CBE
71.67
64%
-107
- C3 -
1MQB
1
EPHA2_HUMAN
A:
[38-318]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
T
E
I
H
P
S
C
V
T
R
Q
K
V
I
G
A
G
E
F
G
E
V
Y
K
G
M
L
K
-
T
--
K
K
E
V
P
V
A
I
K
T
L
K
A
G
Y
T
E
K
Q
R
V
D
F
L
G
E
A
G
I
M
G
Q
F
S
H
H
N
I
I
R
L
E
G
V
I
S
K
Y
K
P
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
E
--
K
D
G
E
F
S
V
L
Q
-
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
-------------------
K
I
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
L
S
-
N
H
E
V
M
K
A
I
N
D
G
F
R
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
S
I
L
D
K
L
I
R
A
P
D
S
L
K
T
L
A
D
F
--------------------------------------------------------------------------------------------------
94
PsiBlast_CBE
64.49
41%
-96
- C3 -
4K8A
1
B:
[9-277]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
Q
R
E
R
I
E
L
G
R
C
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
M
-
S
P
E
N
P
A
L
A
V
A
I
K
T
C
K
N
C
T
S
D
S
V
R
E
K
F
L
Q
E
A
L
T
M
R
Q
F
D
H
P
H
I
V
K
L
I
G
V
I
T
E
N
P
V
-
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
V
--
R
K
Y
S
L
D
L
A
S
-
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
S
N
D
C
V
K
L
G
D
F
G
L
S
R
Y
-----------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
-
N
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
S
T
I
L
E
E
E
K
----------------------------------------------------------------------------------------------------------
103
PsiBlast_CBE
63.46
41%
-100
- C3 -
4I4E
1
A:
[11-280]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
Q
R
E
R
I
E
L
G
R
C
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
M
-
S
P
-
N
P
A
L
A
V
A
I
K
T
C
K
N
C
T
S
D
S
V
R
E
K
F
L
Q
E
A
L
T
M
R
Q
F
D
H
P
H
I
V
K
L
I
G
V
I
T
E
N
P
V
-
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
V
--
R
K
Y
S
L
D
L
A
S
-
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
S
N
D
C
V
K
L
G
D
F
----------------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
-
N
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
S
T
I
L
E
E
E
K
A
Q
--------------------------------------------------------------------------------------------------------
117
PsiBlast_CBE
63.36
41%
-102
- C3 -
4D4V
2
FAK1_CHICK
A:
[6-270]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
Q
R
E
R
I
E
L
G
R
C
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
M
-
S
P
E
N
P
A
M
A
V
A
I
K
T
C
K
N
C
T
S
D
S
V
R
E
K
F
L
Q
E
A
L
T
M
R
Q
F
D
H
P
H
I
V
K
L
I
G
V
I
T
E
N
P
V
-
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
V
--
R
K
F
S
L
D
L
A
S
-
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
A
T
D
C
V
K
L
G
D
F
--------------------
G
K
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
-
N
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
S
T
I
L
E
E
E
K
L
Q
--------------------------------------------------------------------------------------------------------
85
PsiBlast_CBE
63.15
41%
-101
* C3 *
2IJM
1
B:
[8-277]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
Q
R
E
R
I
E
L
G
R
C
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
M
-
S
P
E
N
P
A
L
A
V
A
I
K
T
C
K
N
C
T
S
D
S
V
R
E
K
F
L
Q
E
A
L
T
M
R
Q
F
D
H
P
H
I
V
K
L
I
G
V
I
T
E
N
P
V
-
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
V
--
R
K
Y
S
L
D
L
A
S
-
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
S
N
D
C
V
K
L
G
D
F
G
L
S
-------------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
-
N
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
S
T
I
L
E
E
E
K
A
Q
Q
E
E
-----------------------------------------------------------------------------------------------------
97
PsiBlast_CBE
62.93
41%
-104
- C3 -
4GU9
1
FAK1_HUMAN
A:
[9-278]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
Q
R
E
R
I
E
L
G
R
C
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
M
-
S
P
--
P
A
L
A
V
A
I
K
T
C
K
N
C
T
S
D
S
V
R
E
K
F
L
Q
E
A
L
T
M
R
Q
F
D
H
P
H
I
V
K
L
I
G
V
I
T
E
N
P
V
-
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
V
--
R
K
Y
S
L
D
L
A
S
-
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
S
N
D
C
V
K
L
G
D
F
----------------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
-
N
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
S
T
I
L
E
E
E
K
A
---------------------------------------------------------------------------------------------------------
89
PsiBlast_CBE
62.90
41%
-101
- C3 -
4EBW
1
A:
[29-303]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
T
R
D
Y
--
E
I
Q
R
E
R
I
E
L
G
R
C
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
M
-
S
--
N
P
A
L
A
V
A
I
K
T
C
K
N
C
T
S
D
S
V
R
E
K
F
L
Q
E
A
L
T
M
R
Q
F
D
H
P
H
I
V
K
L
I
G
V
I
T
E
N
P
V
-
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
V
--
R
K
Y
S
L
D
L
A
S
-
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
S
N
D
C
V
K
L
G
D
F
G
L
-------------------
K
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
-
N
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
S
T
I
L
E
E
E
K
A
Q
--------------------------------------------------------------------------------------------------------
104
PsiBlast_CBE
62.88
42%
-102
- C3 -
2JKM
1
A:
[6-270]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
Q
R
E
R
I
E
L
G
R
C
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
M
-
S
P
E
N
P
A
M
A
V
A
I
K
T
C
K
N
C
T
S
D
S
V
R
E
K
F
L
Q
E
A
L
T
M
R
Q
F
D
H
P
H
I
V
K
L
I
G
V
I
T
E
N
P
V
-
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
V
--
R
K
Y
S
L
D
L
A
S
-
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
S
N
D
C
V
K
L
G
D
F
G
L
S
R
------------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
-
N
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
S
T
I
L
E
E
E
K
L
Q
--------------------------------------------------------------------------------------------------------
90
PsiBlast_CBE
62.86
41%
-96
- C3 -
4EBV
3
A:
[28-303]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
S
T
R
D
Y
--
E
I
Q
R
E
R
I
E
L
G
R
C
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
M
-
S
P
E
N
P
A
L
A
V
A
I
K
T
C
K
N
C
T
S
D
S
V
R
E
K
F
L
Q
E
A
L
T
M
R
Q
F
D
H
P
H
I
V
K
L
I
G
V
I
T
E
N
P
V
-
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
V
--
R
K
Y
S
L
D
L
A
S
-
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
S
N
D
C
V
K
L
G
D
F
G
L
-------------------
K
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
-
N
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
S
T
I
L
E
E
E
K
A
Q
--------------------------------------------------------------------------------------------------------
86
PsiBlast_CBE
62.72
41%
-99
- C3 -
2IJM
1
FAK1_HUMAN
A:
[8-277]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
Q
R
E
R
I
E
L
G
R
C
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
M
-
S
P
E
N
P
A
L
A
V
A
I
K
T
C
K
N
C
T
S
D
S
V
R
E
K
F
L
Q
E
A
L
T
M
R
Q
F
D
H
P
H
I
V
K
L
I
G
V
I
T
E
N
P
V
-
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
V
--
R
K
Y
S
L
D
L
A
S
-
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
S
N
D
C
V
K
L
G
D
F
G
L
S
-------------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
-
N
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
S
T
I
L
E
E
E
K
A
Q
Q
E
------------------------------------------------------------------------------------------------------
111
PsiBlast_CBE
62.66
41%
-104
- C3 -
4D58
1
?
B:
[6-270]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
Q
R
E
R
I
E
L
G
R
C
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
M
-
S
P
E
N
P
A
M
A
V
A
I
K
T
C
K
N
C
T
S
D
S
V
R
E
K
F
L
Q
E
A
L
T
M
R
Q
F
D
H
P
H
I
V
K
L
I
G
V
I
T
E
N
P
V
-
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
V
--
R
K
F
S
L
D
L
A
S
-
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
A
T
D
C
V
K
L
G
D
F
G
L
S
R
Y
M
----------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
-
N
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
S
T
I
L
E
E
E
K
L
Q
--------------------------------------------------------------------------------------------------------
96
PsiBlast_CBE
62.66
41%
-98
- C3 -
4GU9
1
B:
[9-276]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
Q
R
E
R
I
E
L
G
R
C
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
M
-
S
P
--
P
A
L
A
V
A
I
K
T
C
K
N
C
T
S
D
S
V
R
E
K
F
L
Q
E
A
L
T
M
R
Q
F
D
H
P
H
I
V
K
L
I
G
V
I
T
E
N
P
V
-
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
V
--
R
K
Y
S
L
D
L
A
S
-
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
S
N
D
C
V
K
L
G
D
F
G
L
S
R
Y
M
----------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
-
N
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
S
T
I
L
E
E
E
-----------------------------------------------------------------------------------------------------------
95
PsiBlast_CBE
62.64
41%
-102
- C3 -
4K8A
1
FAK1_HUMAN
A:
[9-276]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
Q
R
E
R
I
E
L
G
R
C
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
M
-
S
P
--
P
A
L
A
V
A
I
K
T
C
K
N
C
T
S
D
S
V
R
E
K
F
L
Q
E
A
L
T
M
R
Q
F
D
H
P
H
I
V
K
L
I
G
V
I
T
E
N
P
V
-
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
V
--
R
K
Y
S
L
D
L
A
S
-
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
S
N
D
C
V
K
L
G
D
F
G
---------------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
-
N
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
S
T
I
L
E
E
E
-----------------------------------------------------------------------------------------------------------
84
PsiBlast_CBE
62.64
41%
-100
- C3 -
3PXK
1
FAK1_HUMAN
A:
[8-278]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
E
I
Q
R
E
R
I
E
L
G
R
C
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
M
-
S
P
E
N
P
A
L
A
V
A
I
K
T
C
K
N
C
T
S
D
S
V
R
E
K
F
L
Q
E
A
L
T
M
R
Q
F
D
H
P
H
I
V
K
L
I
G
V
I
T
E
N
P
V
-
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
V
--
R
K
Y
S
L
D
L
A
S
-
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
S
N
D
C
V
K
L
G
D
F
G
---------------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
-
N
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
S
T
I
L
E
E
E
K
A
Q
Q
-------------------------------------------------------------------------------------------------------
78
PsiBlast_CBE
62.57
44%
-103
- C3 -
4CSV
1
?
A:
[7-268]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
P
R
S
E
I
T
L
E
R
K
L
G
S
G
Q
F
G
E
V
Y
E
G
K
W
R
----
N
Y
N
I
E
V
A
V
K
T
L
K
E
G
T
M
S
V
E
--
E
F
L
Q
E
A
Q
I
M
K
K
L
K
H
P
N
L
V
Q
L
Y
G
V
C
T
K
E
P
P
I
Y
I
I
T
E
Y
M
S
H
G
S
L
L
D
Y
L
R
D
--
C
----
V
N
A
Q
A
L
L
D
M
A
A
Q
V
A
S
G
M
A
Y
L
E
S
Q
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
N
V
V
K
V
A
D
F
G
---------------------
F
P
I
K
W
T
A
P
E
A
I
S
Y
N
R
F
S
I
K
S
D
V
W
A
F
G
I
L
L
W
E
I
F
T
Y
G
Q
V
P
Y
P
G
M
S
-
G
S
E
V
I
E
Q
V
E
R
G
Y
R
M
P
R
P
Q
G
C
P
E
E
I
Y
E
L
M
L
Q
C
W
N
K
S
P
E
E
R
P
T
F
A
E
T
L
H
A
L
E
T
M
F
L
-------------------------------------------------------------------------------------------------------------
105
PsiBlast_CBE
62.37
41%
-96
- C3 -
1MP8
1
A:
[11-280]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
Q
R
E
R
I
E
L
G
R
C
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
M
-
S
P
--
P
A
L
A
V
A
I
K
T
C
K
N
C
T
S
D
S
V
R
E
K
F
L
Q
E
A
L
T
M
R
Q
F
D
H
P
H
I
V
K
L
I
G
V
I
T
E
N
P
V
-
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
V
--
R
K
Y
S
L
D
L
A
S
-
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
S
N
D
C
V
K
L
G
D
-----------------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
-
N
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
S
T
I
L
E
E
E
K
A
Q
--------------------------------------------------------------------------------------------------------
100
PsiBlast_CBE
62.32
42%
-109
- C3 -
2J0M
1
?
B:
[6-270]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
Q
R
E
R
I
E
L
G
R
C
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
M
-
S
P
E
N
P
A
L
A
V
A
I
K
T
C
K
N
C
T
S
D
S
V
R
E
K
F
L
Q
E
A
L
T
M
R
Q
F
D
H
P
H
I
V
K
L
I
G
V
I
T
E
N
P
V
-
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
V
--
R
K
Y
S
L
D
L
A
S
-
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
S
N
D
C
V
K
L
G
D
F
G
L
--------------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
-
N
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
S
T
I
L
E
E
E
K
L
Q
--------------------------------------------------------------------------------------------------------
98
PsiBlast_CBE
62.21
41%
-99
- C3 -
3BZ3
1
A:
[3-272]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
Q
R
E
R
I
E
L
G
R
C
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
M
-
S
P
----
L
A
V
A
I
K
T
C
K
N
C
T
S
D
S
V
R
E
K
F
L
Q
E
A
L
T
M
R
Q
F
D
H
P
H
I
V
K
L
I
G
V
I
T
E
N
P
V
-
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
V
--
R
K
Y
S
L
D
L
A
S
-
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
S
N
D
C
V
K
L
G
D
F
G
L
S
R
Y
-----------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
-
N
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
S
T
I
L
E
E
E
K
A
Q
Q
E
E
-----------------------------------------------------------------------------------------------------
102
PsiBlast_CBE
62.09
41%
-101
- C3 -
4I4F
2
A:
[11-280]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
Q
R
E
R
I
E
L
G
R
C
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
M
-
S
P
---
A
L
A
V
A
I
K
T
C
K
N
C
T
S
D
S
V
R
E
K
F
L
Q
E
A
L
T
M
R
Q
F
D
H
P
H
I
V
K
L
I
G
V
I
T
E
N
P
V
-
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
V
--
R
K
Y
S
L
D
L
A
S
-
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
S
N
D
C
V
K
L
G
D
F
G
L
S
------------------
K
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
-
N
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
S
T
I
L
E
E
E
K
A
Q
--------------------------------------------------------------------------------------------------------
106
PsiBlast_CBE
62.08
41%
-97
- C3 -
2J0J
1
FAK1_CHICK
A:
[373-650]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
E
D
T
Y
T
M
P
--
S
T
R
D
Y
--
E
I
Q
R
E
R
I
E
L
G
R
C
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
M
-
S
P
E
N
P
A
M
A
V
A
I
K
T
C
K
N
C
T
S
D
S
V
R
E
K
F
L
Q
E
A
L
T
M
R
Q
F
D
H
P
H
I
V
K
L
I
G
V
I
T
E
N
P
V
-
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
V
--
R
K
F
S
L
D
L
A
S
-
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
S
N
D
C
V
K
L
G
D
F
G
L
S
R
Y
M
E
D
--------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
-
N
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
S
T
I
L
E
E
E
K
L
Q
--------------------------------------------------------------------------------------------------------
116
PsiBlast_CBE
62.04
41%
-105
- C3 -
4D4V
2
B:
[6-270]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
Q
R
E
R
I
E
L
G
R
C
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
M
-
S
P
E
N
P
A
M
A
V
A
I
K
T
C
K
N
C
T
S
D
S
V
R
E
K
F
L
Q
E
A
L
T
M
R
Q
F
D
H
P
H
I
V
K
L
I
G
V
I
T
E
N
P
V
-
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
V
--
R
K
F
S
L
D
L
A
S
-
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
A
T
D
C
V
K
L
G
D
F
G
---------------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
-
N
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
S
T
I
L
E
E
E
K
L
Q
--------------------------------------------------------------------------------------------------------
99
PsiBlast_CBE
62.01
42%
-98
- C3 -
2JKQ
1
A:
[6-270]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
Q
R
E
R
I
E
L
G
R
C
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
M
-
S
P
E
N
P
A
L
A
V
A
I
K
T
C
K
N
C
T
S
D
S
V
R
E
K
F
L
Q
E
A
L
T
M
R
Q
F
D
H
P
H
I
V
K
L
I
G
V
I
T
E
N
P
V
-
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
V
--
R
K
Y
S
L
D
L
A
S
-
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
S
N
D
C
V
K
L
G
D
F
G
L
S
-------------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
-
N
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
S
T
I
L
E
E
E
K
L
Q
--------------------------------------------------------------------------------------------------------
83
PsiBlast_CBE
61.99
41%
-97
- C3 -
3PXK
1
B:
[7-278]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Y
E
I
Q
R
E
R
I
E
L
G
R
C
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
M
-
S
P
E
N
P
A
L
A
V
A
I
K
T
C
K
N
C
T
S
D
S
V
R
E
K
F
L
Q
E
A
L
T
M
R
Q
F
D
H
P
H
I
V
K
L
I
G
V
I
T
E
N
P
V
-
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
V
--
R
K
Y
S
L
D
L
A
S
-
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
S
N
D
C
V
K
L
G
D
F
G
L
--------------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
-
N
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
S
T
I
L
E
E
E
K
A
Q
Q
-------------------------------------------------------------------------------------------------------
87
PsiBlast_CBE
61.90
41%
-97
- C3 -
2ETM
1
B:
[8-277]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
Q
R
E
R
I
E
L
G
R
C
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
M
-
S
P
E
N
P
A
L
A
V
A
I
K
T
C
K
N
C
T
S
D
S
V
R
E
K
F
L
Q
E
A
L
T
M
R
Q
F
D
H
P
H
I
V
K
L
I
G
V
I
T
E
N
P
V
-
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
V
--
R
K
Y
S
L
D
L
A
S
-
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
S
N
D
C
V
K
L
G
D
F
G
L
S
R
------------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
-
N
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
S
T
I
L
E
E
E
K
A
Q
Q
E
E
-----------------------------------------------------------------------------------------------------
110
PsiBlast_CBE
61.68
41%
-102
- C3 -
4D5H
1
FAK1_CHICK
A:
[6-270]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
Q
R
E
R
I
E
L
G
R
C
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
M
-
S
P
E
N
P
A
M
A
V
A
I
K
T
C
K
N
C
T
S
D
S
V
R
E
K
F
L
Q
E
A
L
T
M
R
Q
F
D
H
P
H
I
V
K
L
I
G
V
I
T
E
N
P
V
-
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
V
--
R
K
F
S
L
D
L
A
S
-
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
A
T
D
C
V
K
L
G
D
F
---------------------
K
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
-
N
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
S
T
I
L
E
E
E
K
L
Q
--------------------------------------------------------------------------------------------------------
101
PsiBlast_CBE
61.55
41%
-97
- C3 -
4Q9S
1
A:
[11-280]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
Q
R
E
R
I
E
L
G
R
C
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
M
-
S
P
--
P
A
L
A
V
A
I
K
T
C
K
N
C
T
S
D
S
V
R
E
K
F
L
Q
E
A
L
T
M
R
Q
F
D
H
P
H
I
V
K
L
I
G
V
I
T
E
N
P
V
-
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
V
--
R
K
Y
S
L
D
L
A
S
-
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
S
N
D
C
V
K
L
G
D
-----------------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
-
N
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
S
T
I
L
E
E
E
K
A
Q
--------------------------------------------------------------------------------------------------------
79
PsiBlast_CBE
61.54
41%
-99
- C3 -
4KAO
1
B:
[7-278]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Y
E
I
Q
R
E
R
I
E
L
G
R
C
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
M
-
S
P
--
P
A
L
A
V
A
I
K
T
C
K
N
C
T
S
D
S
V
R
E
K
F
L
Q
E
A
L
T
M
R
Q
F
D
H
P
H
I
V
K
L
I
G
V
I
T
E
N
P
V
-
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
V
--
R
K
Y
S
L
D
L
A
S
-
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
S
N
D
C
V
K
L
G
D
F
G
---------------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
-
N
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
S
T
I
L
E
E
E
K
A
Q
--------------------------------------------------------------------------------------------------------
91
PsiBlast_CBE
61.35
41%
-99
- C3 -
4KAB
1
B:
[9-277]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
Q
R
E
R
I
E
L
G
R
C
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
M
-
S
P
E
-
P
A
L
A
V
A
I
K
T
C
K
N
C
T
S
D
S
V
R
E
K
F
L
Q
E
A
L
T
M
R
Q
F
D
H
P
H
I
V
K
L
I
G
V
I
T
E
N
P
V
-
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
V
--
R
K
Y
S
L
D
L
A
S
-
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
S
N
D
C
V
K
L
G
D
F
G
L
S
R
Y
M
----------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
-
N
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
S
T
I
L
E
E
E
K
----------------------------------------------------------------------------------------------------------
81
PsiBlast_CBE
61.17
41%
-98
- C3 -
4GU6
1
B:
[8-278]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
E
I
Q
R
E
R
I
E
L
G
R
C
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
M
-
S
P
E
N
P
A
L
A
V
A
I
K
T
C
K
N
C
T
S
D
S
V
R
E
K
F
L
Q
E
A
L
T
M
R
Q
F
D
H
P
H
I
V
K
L
I
G
V
I
T
E
N
P
V
-
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
V
--
R
K
Y
S
L
D
L
A
S
-
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
S
N
D
C
V
K
L
G
D
F
G
L
S
R
------------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
-
N
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
S
T
I
L
E
E
E
K
A
Q
--------------------------------------------------------------------------------------------------------
80
PsiBlast_CBE
61.10
41%
-100
- C3 -
4KAO
1
FAK1_HUMAN
A:
[8-278]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
E
I
Q
R
E
R
I
E
L
G
R
C
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
M
-
S
P
---
A
L
A
V
A
I
K
T
C
K
N
C
T
S
D
S
V
R
E
K
F
L
Q
E
A
L
T
M
R
Q
F
D
H
P
H
I
V
K
L
I
G
V
I
T
E
N
P
V
-
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
V
--
R
K
Y
S
L
D
L
A
S
-
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
S
N
D
C
V
K
L
G
D
F
G
---------------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
-
N
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
S
T
I
L
E
E
E
K
A
Q
--------------------------------------------------------------------------------------------------------
88
PsiBlast_CBE
60.78
41%
-97
- C3 -
2ETM
1
FAK1_HUMAN
A:
[8-277]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
Q
R
E
R
I
E
L
G
R
C
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
M
-
S
P
E
N
P
A
L
A
V
A
I
K
T
C
K
N
C
T
S
D
S
V
R
E
K
F
L
Q
E
A
L
T
M
R
Q
F
D
H
P
H
I
V
K
L
I
G
V
I
T
E
N
P
V
-
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
V
--
R
K
Y
S
L
D
L
A
S
-
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
S
N
D
C
V
K
L
G
D
F
G
L
S
R
Y
M
E
--------------
K
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
-
N
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
S
T
I
L
E
E
E
K
A
Q
--------------------------------------------------------------------------------------------------------
92
PsiBlast_CBE
60.76
41%
-103
- C3 -
4KAB
1
FAK1_HUMAN
A:
[9-278]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
Q
R
E
R
I
E
L
G
R
C
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
M
-
S
P
--
P
A
L
A
V
A
I
K
T
C
K
N
C
T
S
D
S
V
R
E
K
F
L
Q
E
A
L
T
M
R
Q
F
D
H
P
H
I
V
K
L
I
G
V
I
T
E
N
P
V
-
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
V
--
R
K
Y
S
L
D
L
A
S
-
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
S
N
D
C
V
K
L
G
D
F
----------------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
-
N
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
S
T
I
L
E
E
E
K
A
Q
--------------------------------------------------------------------------------------------------------
93
PsiBlast_CBE
60.18
41%
-93
- C3 -
4K9Y
1
A:
[9-278]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
Q
R
E
R
I
E
L
G
R
C
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
M
-
S
P
E
N
P
A
L
A
V
A
I
K
T
C
K
N
C
T
S
D
S
V
R
E
K
F
L
Q
E
A
L
T
M
R
Q
F
D
H
P
H
I
V
K
L
I
G
V
I
T
E
N
P
V
-
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
V
--
R
K
Y
S
L
D
L
A
S
-
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
S
N
D
C
V
K
L
G
D
F
G
L
S
R
Y
M
E
D
S
--
T
Y
Y
K
A
S
--
K
G
K
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
-
N
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
S
T
I
L
E
E
E
K
A
---------------------------------------------------------------------------------------------------------
82
PsiBlast_CBE
59.92
41%
-92
- C3 -
4GU6
1
FAK1_HUMAN
A:
[7-278]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Y
E
I
Q
R
E
R
I
E
L
G
R
C
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
M
-
S
--
N
P
A
L
A
V
A
I
K
T
C
K
N
C
T
S
D
S
V
R
E
K
F
L
Q
E
A
L
T
M
R
Q
F
D
H
P
H
I
V
K
L
I
G
V
I
T
E
N
P
V
-
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
V
--
R
K
Y
S
L
D
L
A
S
-
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
S
N
D
C
V
K
L
G
D
F
G
L
S
R
Y
M
E
D
S
--
T
Y
Y
K
A
S
--
K
G
K
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
-
N
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
S
T
I
L
E
E
E
K
A
Q
--------------------------------------------------------------------------------------------------------
119
Fugue
59.60
42%
-100
- C3 -
1BYG
1
CSK_HUMAN
A:
[15-276]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
W
A
L
N
M
K
E
L
K
L
L
Q
T
I
G
K
G
E
F
G
D
V
M
L
G
D
Y
R
G------
N
K
V
A
V
K
C
I
K
-----
N
D
A
Q
A
F
L
A
E
A
S
V
M
T
Q
L
R
H
S
N
L
V
Q
L
L
G
V
I
V
-
E
E
G
L
Y
I
V
T
E
Y
M
A
K
G
S
L
V
D
Y
L
R
S
R
G-
R
S
V
L
G
G
D
C
-
L
L
K
F
S
L
D
V
C
E
A
M
E
Y
L
E
G
N
N
F
V
H
R
D
L
A
A
R
N
V
L
V
S
E
D
N
V
A
K
V
S
D
F
G
--------------------
L
L
P
V
K
W
T
A
P
E
A
L
R
E
K
K
F
S
T
K
S
D
V
W
S
F
G
I
L
L
W
E
I
Y
S
F
G
R
V
P
Y
P
R
I
P
L-
K
D
V
V
P
R
V
E
K
G
Y
K
M
D
A
P
D
G
C
P
P
A
V
Y
E
V
M
K
N
C
W
H
L
D
A
A
M
R
P
S
F
L
Q
L
R
E
Q
L
E
H
I
K
T
H
E
L
----------------------------------------------------------------------------------------------------------
77
PsiBlast_CBE
59.43
44%
-96
- C3 -
4UEU
1
?
A:
[7-268]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
P
R
S
E
I
T
L
E
R
K
L
G
S
G
Q
F
G
E
V
Y
E
G
K
W
R
----
N
Y
N
I
E
V
A
V
K
T
L
K
E
G
T
M
S
V
E
--
E
F
L
Q
E
A
Q
I
M
K
K
L
K
H
P
N
L
V
Q
L
Y
G
V
C
T
K
E
P
P
I
Y
I
I
T
E
Y
M
S
H
G
S
L
L
D
Y
L
R
D
--
C
E
G
H
T
V
N
A
Q
A
L
L
D
M
A
A
Q
V
A
S
G
M
A
Y
L
E
S
Q
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
N
V
V
K
V
A
D
F
G
L
A
R
L
I
--------------
A
K
F
P
I
K
W
T
A
P
E
A
I
S
Y
N
R
F
S
I
K
S
D
V
W
A
F
G
I
L
L
W
E
I
F
T
Y
G
Q
V
P
Y
P
G
M
S
-
G
S
E
V
I
E
Q
V
E
R
G
Y
R
M
P
R
P
Q
G
C
P
E
E
I
Y
E
L
M
L
Q
C
W
N
K
S
P
E
E
R
P
T
F
A
E
T
L
H
A
L
E
T
M
F
--------------------------------------------------------------------------------------------------------------