@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : ERBB3_HUMAN: (2015-10-07 )
MRANDALQVLGLLFSLARGSEVGNSQAVCPGTLNGLSVTGDAENQYQTLYKLYERCEVVMGNLEIVLTGHNADLSFLQWIREVTGYVLVAMNEFSTLPLPNLRVVRGTQVYDGKFAIFVMLNYNTNSSHALRQLRLTQLTEILSGGVYIEKNDKLCHMDTIDWRDIVRDRDAEIVVKDNGRSCPPCHEVCKGRCWGPGSEDCQTLTKTICAPQCNGHCFGPNPNQCCHDECAGGCSGPQDTDCFACRHFNDSGACVPRCPQPLVYNKLTFQLEPNPHTKYQYGGVCVASCPHNFVVDQTSCVRACPPDKMEVDKNGLKMCEPCGGLCPKACEGTGSGSRFQTVDSSNIDGFVNCTKILGNLDFLITGLNGDPWHKIPALDPEKLNVFRTVREITGYLNIQSWPPHMHNFSVFSNLTTIGGRSLYNRGFSLLIMKNLNVTSLGFRSLKEISAGRIYISANRQLCYHHSLNWTKVLRGPTEERLDIKHNRPRRDCVAEGKVCDPLCSSGGCWGPGPGQCLSCRNYSRGGVCVTHCNFLNGEPREFAHEAECFSCHPECQPMEGTATCNGSGSDTCAQCAHFRDGPHCVSSCPHGVLGAKGPIYKYPDVQNECRPCHENCTQGCKGPELQDCLGQTLVLIGKTHLTMALTVIAGLVVIFMMLGGTFLYWRGRRIQNKRAMRRYLERGESIEPLDPSEKANKVLARIFKETELRKLKVLGSGVFGTVHKGVWIPEGESIKIPVCIKVIEDKSGRQSFQAVTDHMLAIGSLDHAHIVRLLGLCPGSSLQLVTQYLPLGSLLDHVRQHRGALGPQLLLNWGVQIAKGMYYLEEHGMVHRNLAARNVLLKSPSQVQVADFGVADLLPPDDKQLLYSEAKTPIKWMALESIHFGKYTHQSDVWSYGVTVWELMTFGAEPYAGLRLAEVPDLLEKGERLAQPQICTIDVYMVMVKCWMIDENIRPTFKELANEFTRMARDPPRYLVIKRESGPGIAPGPEPHGLTNKKLEEVELEPELDLDLDLEAEEDNLATTTLGSALSLPVGTLNRPRGSQSLLSPSSGYMPMNQGNLGESCQESAVSGSSERCPRPVSLHPMPRGCLASESSEGHVTGSEAELQEKVSMCRSRSRSRSPRPRGDSAYHSQRHSLLTPVTPLSPPGLEEEDVNGYVMPDTHLKGTPSSREGTLSSVGLSSVLGTEEEDEDEEYEYMNRRRRHSPPHPPRPSSLEELGYEYMDVGSDLSASLGSTQSCPLHPVPIMPTAGTTPDEDYEYMNRQRDGGGPGGDYAAMGACPASEQGYEEMRAFQGPGHQAPHVHYARLKTLRSLEATDSAFDNPDYWHSRLFPKANAQRT
Atome Classification :
(6 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......---170.......180.......190........200.......210.......220.......230.......240.......250.......260.......270.......280.......290....-...300.......310.......320.......330.......340.---........350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560........570.......580.......590.......-600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770.......780.......790.......800.......810.......820.......830.......840.......850.......860.......870.......880.......890.......900.......910.......920.......930.......940.......950.......960.......970.......980.......990.......1000......1010......1020......1030......1040......1050......1060......1070......1080......1090......1100......1110......1120......1130......1140......1150......1160......1170......1180......1190......1200......1210......1220......1230......1240......1250......1260......1270......1280......1290......1300......1310......1320......1330......1340
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MRA
N
D
A
L
Q
V
L
G
L
L
F
S
L
ARGSEVGNSQAVCPGTLN
G
L
S
VTGDAE
N
Q
Y
Q
T
L
Y
K
L
Y
E
R
C
E
V
V
MG
N
L
E
I
V
L
TGHNA
D
L
S
F
L
Q
W
I
R
E
VT
G
Y
V
L
V
A
MNEFSTLPLP
N
L
R
V
V
R
G
T
Q
V
YDG
K
F
A
I
F
V
M
L
NYNTN
S
S
H
A
L
R
Q
L
R
L
T
Q
L
T
E
I
LSG
G
V
Y
I
EKNDKLCHMDTI
D
W
R
D
I
VRD---RD
A
E
I
V
V
KDNGRSCP
P
C
H
E
V
C-KGRCWGPG
S
E
D
C
Q
T
L
T
K
T
ICAPQCNGHCFGPNP
N
Q
C
C
H
D
ECAGGCSGPQDT
D
C
F
A
C
RHFNDSGACVPRCPQP
L
V
Y
N
K
L
T
F
Q
LEPNPHT
K
Y
Q
YG
G
V
C
V
ASCPH
N
F
V
V-DQTSCVRACPPDKMEVDKNG
L
K
MCEPCGGLC
P
K
ACEGTGSGS
R
F
--
Q
---TVDSSNI
D
G
F
V
N
C
T
K
I
LG
N
L
D
F
L
I
TGLNGDPWHKIPAL
D
P
E
K
L
N
V
F
R
T
V
R
E
I
T
G
Y
L
NIQSWPPHMHN
F
S
V
F
SN
L
T
TIGG
R
S
L
Y
NRG
F
S
L
L
I
M
KNLNV
T
S
L
G
F
R
S
L
K
E
ISA
G
R
I
Y
I
SAN
R
Q
L
C
Y
HHSL
N
W
T
K
VLRGP
T
E
E
RLDIKHNRP
R
R
D
C
VAEGKVCDPLCSSGGCWGPGPG
Q
C
LSCRNYSRG
G
V
C
V
T
H
CNFLNG
E
P
R
E
F
A
HEA
E
C
FSCHPECQPME-G
T
A
TCNGSGS
D
T
C
A
Q
C
A
HFRDGP
H
C
V
S
SCPHGVLGAKGP-IYKYPD
V
Q
N
EC
R
P
C
H
E
N
C
TQGCKGP
E
L
Q
D
C
L
G
Q
T
L
V
L
IGK
T
H
L
T
M
A
L
T
V
I
A
G
L
V
V
I
F
M
M
LGG
T
F
L
Y
WRGRRIQ
N
K
R
A
M
R
R
Y
L
E
RGESIEPLD
P
S
E
K
A
N
K
V
L
A
R
I
F
K
E
T
E
L
R
K
L
K
VLGSGV
F
G
TVHK
G
V
WIPEG
E
S
I
K
I
P
V
C
I
K
V
IEDKSGR
Q
S
F
Q
A
V
T
D
H
M
L
A
IGSL
D
H
A
H
I
V
R
L
L
GLCPG
S
S
L
Q
L
V
T
Q
YL
P
L
G
S
L
L
D
H
V
R
Q
H
RGAL
G
P
Q
L
L
L
N
WG
V
Q
I
A
K
G
M
Y
Y
L
E
EH
G
M
V
H
R
N
L
A
ARNVLLKSPS
Q
V
Q
V
A
DFG
V
A
DLLPPD
D
K
Q
L
L
Y
S
EAKT
P
I
K
W
M
A
L
E
SIHFGKYTHQS
D
V
W
S
Y
G
V
T
V
W
E
L
M
TFGAEPYAGL
R
L
A
E
V
P
D
L
L
E
K
G
E
R
LAQP
Q
I
C
T
I
D
V
Y
M
V
M
V
K
C
W
MIDENI
R
P
T
F
K
E
L
A
N
E
F
T
R
MARDPP
R
Y
L
V
I
KRESGPGIAPGPEPHGLTNK
K
L
E
EVELEPELDL
D
L
DLEAEEDNL
A
T
T
TLGSALSLPVGTLNRPRGSQSLLSPSSGYMPMNQGNLG
E
S
C
Q
E
S
AVSGSSERCPRPVSLHPMPRGCLASESSEGHVTG
S
E
A
E
L
Q
E
K
V
S
M
C
R
S
RSRSRSPRPRGDS
A
Y
H
S
Q
R
H
SLLTPVTPLSPPGLEEEDVN
G
Y
VMPDTHLKGTPSSREG
T
L
S
S
V
G
L
S
S
VLGTEEEDE
D
E
E
Y
E
Y
M
N
R
RRRHSPPHPPRP
S
S
L
E
E
L
G
Y
E
Y
M
DVGS
D
L
S
A
SLGSTQSCPLHPVPIMPTAGTTP
D
E
D
Y
E
Y
M
NRQRDGGGPGGD
Y
A
AMGACPASEQ
G
Y
E
E
M
R
A
FQGPGHQAP
H
V
H
Y
A
R
L
K
T
L
R
S
LEATDSAFDN
P
D
Y
W
H
SRLFPKANAQRT
21
PsiBlast_CBE
92.24
99%
-109
- C5 -
1M6B
6
ERBB3_HUMAN
B:
[6-611]
------------------------
S
Q
A
V
C
P
G
T
----------------------
R
C
E
V
V
M
G
N
L
E
I
V
L
T
G
H
N
A
D
L
S
F
L
Q
W
V
R
E
V
T
G
Y
V
L
V
A
M
N
E
F
S
T
L
P
L
P
N
L
R
V
V
R
G
T
Q
V
Y
D
G
K
F
A
I
F
V
M
L
N
Y
N
T
N
S
S
H
A
L
R
Q
L
R
L
T
Q
L
T
E
I
L
S
G
G
V
Y
I
E
K
N
D
K
L
C
H
M
D
T
I
D
W
R
D
I
V
R
D
---
R
D
A
E
I
V
V
K
D
N
G
R
S
C
P
P
C
H
E
V
C
-
K
G
R
C
W
G
P
G
S
E
D
C
Q
T
L
T
K
T
I
C
A
P
Q
C
N
G
H
C
F
G
P
N
P
N
Q
C
C
H
D
E
C
A
G
G
C
S
G
P
Q
D
T
D
C
F
A
C
R
H
F
N
D
S
G
A
C
V
P
R
C
P
Q
P
L
V
Y
N
K
L
T
F
Q
L
E
P
N
P
H
T
K
Y
Q
Y
G
G
V
C
V
A
S
C
P
H
N
F
V
V
-
D
Q
T
S
C
V
R
A
C
P
P
D
K
M
E
V
D
K
N
G
L
K
M
C
E
P
C
G
G
L
C
P
K
A
C
E
G
T
G
S
G
S
R
F
--
Q
---
T
V
D
S
S
N
I
D
G
F
V
N
C
T
K
I
L
G
N
L
D
F
L
I
T
G
L
N
G
D
P
W
H
K
I
P
A
L
D
P
E
K
L
N
V
F
R
T
V
R
E
I
T
G
Y
L
N
I
Q
S
W
P
P
H
M
H
N
F
S
V
F
S
N
L
T
T
I
G
G
R
S
L
Y
N
R
G
F
S
L
L
I
M
K
N
L
N
V
T
S
L
G
F
R
S
L
K
E
I
S
A
G
R
I
Y
I
S
A
N
R
Q
L
C
Y
H
H
S
L
N
W
T
K
V
L
R
G
P
T
E
E
R
L
D
I
K
H
N
R
P
R
R
D
C
V
A
E
G
K
V
C
D
P
L
C
S
S
G
G
C
W
G
P
G
P
G
Q
C
L
S
C
R
N
Y
S
R
G
G
V
C
V
T
H
C
N
F
L
N
G
E
P
R
E
F
A
H
E
A
E
C
F
S
C
H
P
E
C
Q
P
M
E
-
G
T
A
T
C
N
G
S
G
S
D
T
C
A
Q
C
A
H
F
R
D
G
P
H
C
V
S
S
C
P
H
G
V
L
G
A
K
G
P
-
I
Y
K
Y
P
D
V
Q
N
E
C
R
P
C
H
E
N
C
T
Q
G
C
K
G
P
E
L
Q
D
C
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
79.83
59%
-105
- C5 -
2AHX
8
ERBB4_HUMAN
A:
[2-610]
-------------------------
Q
S
V
C
A
G
T
E
N
K
L
S
S
L
S
D
L
E
Q
Q
Y
R
A
L
R
K
Y
Y
E
N
C
E
V
V
M
G
N
L
E
I
T
S
I
E
H
N
R
D
L
S
F
L
R
S
V
R
E
V
T
G
Y
V
L
V
A
L
N
Q
F
R
Y
L
P
L
E
N
L
R
I
I
R
G
T
K
L
Y
E
D
R
Y
A
L
A
I
F
L
N
Y
R
K
D
G
N
F
G
L
Q
E
L
G
L
K
N
L
T
E
I
L
N
G
G
V
Y
V
D
Q
N
K
F
L
C
Y
A
D
T
I
H
W
Q
D
I
V
R
N
PWP
S
N
L
T
L
V
S
T
----
G
C
G
R
C
H
K
S
C
-
T
G
R
C
W
G
P
T
E
N
H
C
Q
T
L
T
R
T
V
C
A
E
Q
C
D
G
R
C
Y
G
P
Y
V
S
D
C
C
H
R
E
C
A
G
G
C
S
G
P
K
D
T
D
C
F
A
C
M
N
F
N
D
S
G
A
C
V
T
Q
C
P
Q
T
F
V
Y
N
P
T
T
F
Q
L
E
H
N
F
N
A
K
Y
T
Y
G
A
F
C
V
K
K
C
P
H
N
F
V
V
-
D
S
S
S
C
V
R
A
C
P
S
S
K
M
E
V
E
E
N
G
I
K
M
C
K
P
C
T
-
I
C
P
K
A
C
D
G
I
G
T
G
S
L
M
SA
Q
---
T
V
D
S
S
N
I
D
K
F
I
N
C
T
K
I
N
G
N
L
I
F
L
V
T
G
I
H
G
D
P
Y
N
A
I
E
A
I
D
P
E
K
L
N
V
F
R
T
V
R
E
I
T
G
F
L
N
I
Q
S
W
P
P
N
M
T
D
F
S
V
F
S
N
L
V
T
I
G
G
R
V
L
Y
S
-
G
L
S
L
L
I
L
K
Q
Q
G
I
T
S
L
Q
F
Q
S
L
K
E
I
S
A
G
N
I
Y
I
T
D
N
S
N
L
C
Y
Y
H
T
I
N
W
T
-
T
L
F
S
T
I
N
Q
R
I
V
I
R
D
N
R
K
A
E
N
C
T
A
E
G
M
V
C
N
H
L
C
S
S
D
G
C
W
G
P
G
P
D
Q
C
L
S
C
R
R
F
S
R
G
R
I
C
I
E
S
C
N
L
Y
D
G
E
F
R
E
F
E
N
D
S
I
C
V
E
C
D
P
Q
C
E
K
M
E
D
G
L
L
T
C
H
G
P
G
P
D
N
C
T
K
C
S
H
F
K
D
G
P
N
C
V
E
K
C
P
D
G
L
Q
G
A
N
S
F
-
I
F
K
Y
A
D
P
D
R
E
C
H
P
C
H
P
N
C
T
Q
G
C
N
G
P
T
S
H
D
C
I
Y
Y
P
W
T
G
H
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
76.50
45%
-101
- C5 -
3QWQ
2
EGFR_HUMAN
A:
[28-636]
-------------------------
K
K
V
C
Q
G
T
S
N
K
L
T
Q
L
G
T
F
E
D
H
F
L
S
L
Q
R
M
F
N
N
C
E
V
V
L
G
N
L
E
I
T
Y
V
Q
R
N
Y
D
L
S
F
L
K
T
I
Q
E
V
A
G
Y
V
L
I
A
L
N
T
V
E
R
I
P
L
E
N
L
Q
I
I
R
G
N
M
Y
Y
E
N
S
Y
A
L
A
V
L
S
N
Y
D
A
N
K
T
-
G
L
K
E
L
P
M
R
N
L
Q
E
I
L
H
G
A
V
R
F
S
N
N
P
A
L
C
N
V
E
S
I
Q
W
R
D
I
V
S
S
DFL
S
N
M
S
M
D
F
Q
N
H
L
G
S
C
Q
K
C
D
P
S
C
P
N
G
S
C
W
G
A
G
E
E
N
C
Q
K
L
T
K
I
I
C
A
Q
Q
C
S
G
R
C
R
G
K
S
P
S
D
C
C
H
N
Q
C
A
A
G
C
T
G
P
R
E
S
D
C
L
V
C
R
K
F
R
D
E
A
T
C
K
D
T
C
P
P
L
M
L
Y
N
P
T
T
Y
Q
M
D
V
N
P
E
G
K
Y
S
F
G
A
T
C
V
K
K
C
P
R
N
Y
V
V
T
D
H
G
S
C
V
R
A
C
G
A
D
S
Y
E
M
E
E
D
G
V
R
K
C
K
K
C
E
G
P
C
R
K
V
C
N
G
I
G
I
G
-
E
F
--
K
DSL
S
I
N
A
T
N
I
K
H
F
K
N
C
T
S
I
S
G
D
L
H
I
L
P
V
A
F
R
G
D
S
F
T
H
T
P
P
L
D
P
Q
E
L
D
I
L
K
T
V
K
E
I
T
G
F
L
L
I
Q
A
W
P
E
N
R
T
D
L
H
A
F
E
N
L
E
I
I
R
G
R
T
K
Q
H
G
Q
F
S
L
A
V
V
-
S
L
N
I
T
S
L
G
L
R
S
L
K
E
I
S
D
G
D
V
I
I
S
G
N
K
N
L
C
Y
A
N
T
I
N
W
K
K
L
F
-
G
T
S
G
Q
K
T
K
I
I
S
N
R
G
E
N
S
C
K
A
T
G
Q
V
C
H
A
L
C
S
P
E
G
C
W
G
P
E
P
R
D
C
V
S
C
R
N
V
S
R
G
R
E
C
V
D
K
C
N
L
L
E
G
E
P
R
E
F
V
E
N
S
E
C
I
Q
C
H
P
E
C
L
P
Q
A
-
M
N
I
T
C
T
G
R
G
P
D
N
C
I
Q
C
A
H
Y
I
D
G
P
H
C
V
K
T
C
P
A
G
V
M
G
E
N
N
T
L
V
W
K
Y
A
D
A
G
H
V
C
H
L
C
H
P
N
C
T
Y
G
C
T
G
P
G
L
E
G
C
P
T
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
75.54
45%
-97
- C5 -
1NQL
5
EGFR_HUMAN
A:
[4-612]
-------------------------
K
K
V
C
Q
G
T
S
N
K
L
T
Q
L
G
T
F
E
D
H
F
L
S
L
Q
R
M
F
N
N
C
E
V
V
L
G
N
L
E
I
T
Y
V
Q
R
N
Y
D
L
S
F
L
K
T
I
Q
E
V
A
G
Y
V
L
I
A
L
N
T
V
E
R
I
P
L
E
N
L
Q
I
I
R
G
N
M
Y
Y
E
N
S
Y
A
L
A
V
L
S
N
Y
D
A
N
K
T
-
G
L
K
E
L
P
M
R
N
L
Q
E
I
L
H
G
A
V
R
F
S
N
N
P
A
L
C
N
V
E
S
I
Q
W
R
D
I
V
S
S
DFL
S
N
M
S
M
D
F
Q
N
H
L
G
S
C
Q
K
C
D
P
S
C
P
N
G
S
C
W
G
A
G
E
E
N
C
Q
K
L
T
K
I
I
C
A
Q
Q
C
S
G
R
C
R
G
K
S
P
S
D
C
C
H
N
Q
C
A
A
G
C
T
G
P
R
E
S
D
C
L
V
C
R
K
F
R
D
E
A
T
C
K
D
T
C
P
P
L
M
L
Y
N
P
T
T
Y
Q
M
D
V
N
P
E
G
K
Y
S
F
G
A
T
C
V
K
K
C
P
R
N
Y
V
V
T
D
H
G
S
C
V
R
A
C
G
A
D
S
Y
E
M
E
E
D
G
V
R
K
C
K
K
C
E
G
P
C
R
K
V
C
N
G
I
G
I
G
-
E
F
--
K
DSL
S
I
N
A
T
N
I
K
H
F
K
N
C
T
S
I
S
G
D
L
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I
L
P
V
A
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G
D
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P
L
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K
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V
K
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T
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F
L
L
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A
W
P
E
N
R
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D
L
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A
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N
L
E
I
I
R
G
R
T
K
Q
H
G
Q
F
S
L
A
V
V
-
S
L
N
I
T
S
L
G
L
R
S
L
K
E
I
S
D
G
D
V
I
I
S
G
N
K
N
L
C
Y
A
N
T
I
N
W
K
K
L
F
-
G
T
S
G
Q
K
T
K
I
I
S
N
R
G
E
N
S
C
K
A
T
G
Q
V
C
H
A
L
C
S
P
E
G
C
W
G
P
E
P
R
D
C
V
S
C
R
N
V
S
R
G
R
E
C
V
D
K
C
K
L
L
E
G
E
P
R
E
F
V
E
N
S
E
C
I
Q
C
H
P
E
C
L
P
Q
A
-
M
N
I
T
C
T
G
R
G
P
D
N
C
I
Q
C
A
H
Y
I
D
G
P
H
C
V
K
T
C
P
A
G
V
M
G
E
N
N
T
L
V
W
K
Y
A
D
A
G
H
V
C
H
L
C
H
P
N
C
T
Y
G
C
T
G
P
G
L
E
G
C
P
T
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
74.31
61%
-103
- C5 -
3U2P
5
ERBB4_HUMAN
A:
[1-497]
-------------------------
Q
S
V
C
A
G
T
E
N
K
L
S
S
L
S
D
L
E
Q
Q
Y
R
A
L
R
K
Y
Y
E
N
C
E
V
V
M
G
N
L
E
I
T
S
I
E
H
N
R
D
L
S
F
L
R
S
V
R
E
V
T
G
Y
V
L
V
A
L
N
Q
F
R
Y
L
P
L
E
N
L
R
I
I
R
G
T
K
L
Y
E
D
R
Y
A
L
A
I
F
L
N
Y
R
K
D
G
N
F
G
L
Q
E
L
G
L
K
N
L
T
E
I
L
N
G
G
V
Y
V
D
Q
N
K
F
L
C
Y
A
D
T
I
H
W
Q
D
I
V
R
N
P-------------
S
G
C
G
R
C
H
K
S
C
-
T
G
R
C
W
G
P
T
E
N
H
C
Q
T
L
T
R
T
V
C
A
E
Q
C
D
G
R
C
Y
G
P
Y
V
S
D
C
C
H
R
E
C
A
G
G
C
S
G
P
K
D
T
D
C
F
A
C
M
N
F
N
D
S
G
A
C
V
T
Q
C
P
Q
T
F
V
Y
N
P
T
T
F
Q
L
E
H
N
F
N
A
K
Y
T
Y
G
A
F
C
V
K
K
C
P
H
N
F
V
V
-
D
S
S
S
C
V
R
A
C
P
S
S
K
M
E
V
-----
K
M
C
K
P
C
T
D
I
C
P
K
A
C
D
G
I
G
T
G
S
L
M
SA
Q
---
T
V
D
S
S
N
I
D
K
F
I
N
C
T
K
I
N
G
N
L
I
F
L
V
T
G
I
H
G
D
P
Y
N
A
I
E
A
I
D
P
E
K
L
N
V
F
R
T
V
R
E
I
T
G
F
L
N
I
Q
S
W
P
P
N
M
T
D
F
S
V
F
S
N
L
V
T
I
G
G
R
V
L
Y
S
-
G
L
S
L
L
I
L
K
Q
Q
G
I
T
S
L
Q
F
Q
S
L
K
E
I
S
A
G
N
I
Y
I
T
D
N
S
N
L
C
Y
Y
H
T
I
N
W
T
-
T
L
F
S
T
I
N
Q
R
I
V
I
R
D
N
R
K
A
E
N
C
T
A
E
G
M
V
C
N
H
L
C
S
S
D
G
C
W
G
P
G
P
D
Q
C
L
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
61.25
45%
-85
- C5 -
3B2V
2
EGFR_HUMAN
A:
[239-612]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
C
P
P
L
M
L
Y
N
P
T
T
Y
Q
M
D
V
N
P
E
G
K
Y
S
F
G
A
T
C
V
K
K
C
P
R
N
Y
V
V
T
D
H
G
S
C
V
R
A
C
G
A
D
S
Y
E
M
E
E
D
G
V
R
K
C
K
K
C
E
G
P
C
R
K
V
C
N
G
I
G
I
G
-
E
F
--
K
DSL
S
I
N
A
T
N
I
K
H
F
K
N
C
T
S
I
S
G
D
L
H
I
L
P
V
A
F
R
G
D
S
F
T
H
T
P
P
L
D
P
Q
E
L
D
I
L
K
T
V
K
E
I
T
G
F
L
L
I
Q
A
W
P
E
N
R
T
D
L
H
A
F
E
N
L
E
I
I
R
G
R
T
K
Q
H
G
Q
F
S
L
A
V
V
-
S
L
N
I
T
S
L
G
L
R
S
L
K
E
I
S
D
G
D
V
I
I
S
G
N
K
N
L
C
Y
A
N
T
I
N
W
K
K
L
F
-
G
T
S
G
Q
K
T
K
I
I
S
N
R
G
E
N
S
C
K
A
T
G
Q
V
C
H
A
L
C
S
P
E
G
C
W
G
P
E
P
R
D
C
V
S
C
R
N
V
S
R
G
R
E
C
V
D
K
C
N
L
L
E
G
E
P
R
E
F
V
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N
S
E
C
I
Q
C
H
P
E
C
L
P
Q
A
-
M
N
I
T
C
T
G
R
G
P
D
N
C
I
Q
C
A
H
Y
I
D
G
P
H
C
V
K
T
C
P
A
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V
M
G
E
N
N
T
L
V
W
K
Y
A
D
A
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H
V
C
H
L
C
H
P
N
C
T
Y
G
C
T
G
P
G
L
E
G
C
P
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------