@TOME V2.3
(Nov 2016)
Ref.
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : ERN1_HUMAN: (2015-10-07 )
MPARRLLLLLTLLLPGLGIFGSTSTVTLPETLLFVSTLDGSLHAVSKRTGSIKWTLKEDPVLQVPTHVEEPAFLPDPNDGSLYTLGSKNNEGLTKLPFTIPELVQASPCRSSDGILYMGKKQDIWYVIDLLTGEKQQTLSSAFADSLCPSTSLLYLGRTEYTITMYDTKTRELRWNATYFDYAASLPEDDVDYKMSHFVSNGDGLVVTVDSESGDVLWIQNYASPVVAFYVWQREGLRKVMHINVAVETLRYLTFMSGEVGRITKWKYPFPKETEAKSKLTPTLYVGKYSTSLYASPSMVHEGVAVVPRGSTLPLLEGPQTDGVTIGDKGECVITPSTDVKFDPGLKSKNKLNYLRNYWLLIGHHETPLSASTKMLERFPNNLPKHRENVIPADSEKKSFEEVINLVDQTSENAPTTVSRDVEEKPAHAPARPEAPVDSMLKDMATIILSTFLLIGWVAFIITYPLSMHQQQQLQHQQFQKELEKIQLLQQQQQQLPFHPPGDTAQDGELLDTSGPYSESSGTSSPSTSPRASNHSLCSGSSASKAGSSPSLEQDDGDEETSVVIVGKISFCPKDVLGHGAEGTIVYRGMFDNRDVAVKRILPECFSFADREVQLLRESDEHPNVIRYFCTEKDRQFQYIAIELCAATLQEYVEQKDFAHLGLEPITLLQQTTSGLAHLHSLNIVHRDLKPHNILISMPNAHGKIKAMISDFGLCKKLAVGRHSFSRRSGVPGTEGWIAPEMLSEDCKENPTYTVDIFSAGCVFYYVISEGSHPFGKSLQRQANILLGACSLDCLHPEKHEDVIARELIEKMIAMDPQKRPSAKHVLKHPFFWSLEKQLQFFQDVSDRIEKESLDGPIVKQLERGGRAVVKMDWRENITVPLQTDLRKFRTYKGGSVRDLLRAMRNKKHHYRELPAEVRETLGSLPDDFVCYFTSRFPHLLAHTYRAMELCSHERLFQPYYFHEPPEPQPPVTPDAL
Atome Classification :
(6 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.....-..590.......600.......610---.........620.......630.......640.....--..650.......660..--.....670.......680.......690.......700------..--------.......710.......720.......730.......740....----.----..750.......760.......770...-...----.780.......790.---...--...800.......810.......820.......830.......840.......850.....--..860.......870.-.......880.......890.......900.......910.......920.......930.......940.......950........960.......970.....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MP
A
R
R
L
L
L
L
L
T
L
L
LPGLGIFGSTS
T
V
TLP
E
T
L
L
F
V
STLDGSL
H
A
V
SKRTG
S
I
K
W
T
LKEDP
V
L
QVPTHVEEPAFLPDPNDG
S
L
Y
T
LGSKNNEG
L
T
KLPFT
I
P
E
L
VQASPCRSSD
G
I
L
Y
MGKKQ
D
I
W
Y
V
I
D
LLTG
E
K
Q
Q
T
L
S
S
A
F
A
D
SLCPST
S
L
L
Y
L
GRT
E
Y
T
I
T
M
YDTKT
R
E
L
R
WN
A
T
Y
F
D
Y
A
ASLPED
D
V
D
Y
K
M
S
H
FVSNG
D
G
L
V
V
T
V
DSESG
D
V
L
W
I
QNYAS
P
V
V
A
F
Y
V
W
Q
R
EG
L
R
K
V
M
H
I
N
V
A
V
E
T
L
R
Y
L
T
FMSGEVGRI
T
K
WKYPFPKETEAKSKLT
P
T
L
Y
V
GKYSTSLYAS
P
S
M
VHE
G
V
A
VVPRGSTLPLLEGPQTD
G
V
T
IGDKG
E
C
V
ITPSTD
V
K
FDPGLKSK
N
K
L
N
Y
L
R
N
Y
W
L
L
I
GHHETPL
S
A
S
T
K
M
L
E
RFPNNLP
K
H
R
ENVIPADS
E
K
K
S
F
E
E
V
I
N
L
V
D
QTSENAPTTVSRDVEEKPAHAPARPEA
P
V
D
S
M
L
K
D
M
A
T
I
I
L
S
T
F
L
L
I
G
W
V
A
F
I
I
TYPL
S
M
H
Q
Q
Q
Q
L
Q
H
Q
Q
F
Q
K
E
L
E
K
I
Q
L
L
Q
Q
Q
Q
Q
QLPFHPPGDTAQDGELLDTSGPYSESSGTSSPSTSPRASNHSLCSGSSASKAGSSPSLEQDDGDEE
T
S
V
V
I
V
G
KISFC
P
K
D
V
LGHGAE
G
T
I
V
Y
-
R
GMFDNR
D
V
A
V
K
R
I
L
P
E
C
F
S
F
A
D
-----
R
E
V
Q
L
L
R
ESDEHP
N
V
I
R
Y
F
CTEKDR
Q
F
Q
Y
I
A
I
E
L
C
A
A
--
T
L
Q
E
Y
V
E
Q
K
D
F
A
HLGL
E
--
P
I
T
L
L
Q
Q
T
T
S
G
L
A
H
L
H
S
L
N
I
V
HRDLKP
H
N
I
L
I
SMPN--------AH--------
G
K
I
K
A
M
I
S
D
F
G
L
C
K
K
L
A
VGRHSFSRRSGVPGTEGWI
A
P
E
M
L
S
E
D
----
C
----KENP
T
Y
T
V
D
I
FSAG
C
V
F
Y
Y
V
ISEGSH
P
F
-
G
K
S
----
L
Q
R
QA
N
I
L
L
G
ACSLD---CLH--
P
E
K
H
E
D
V
I
A
R
E
L
I
E
K
M
IAMDPQKRP
S
A
K
H
V
L
KHP
F
F
W
S
L
E
K
Q
L
Q
F
F
Q
D
V
S
D
R
I
E
K
ESLD
G
P
--
I
V
K
Q
L
E
RGG
R
A
V
V
-
K
M
-DWRENITV
P
L
Q
T
D
L
R
K
F
RTYKGG
S
V
R
D
L
L
R
A
M
RNKK
H
H
Y
R
EL
P
A
E
V
R
E
T
L
GSLP
D
D
F
V
C
Y
F
T
SR
F
P
H
L
L
A
H
T
Y
R
A
M
E
L
-
C
S
H
ERLFQPYYFHEPPEPQPPVTPDAL
4
PsiBlast_PDB
94.18
100%
-109
- C1 -
4Z7H
1
ERN1_HUMAN
A:
[1-402]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
V
V
I
V
G
K
I
S
F
C
P
K
D
V
L
G
H
G
A
E
G
T
I
V
Y
-
R
G
M
F
D
N
R
D
V
A
V
K
R
I
L
P
E
C
F
S
F
A
D
-----
R
E
V
Q
L
L
R
E
S
D
E
H
P
N
V
I
R
Y
F
C
T
E
K
D
R
Q
F
Q
Y
I
A
I
E
L
C
A
A
--
T
L
Q
E
Y
V
E
Q
K
D
F
A
H
L
G
L
E
--
P
I
T
L
L
Q
Q
T
T
S
G
L
A
H
L
H
S
L
N
I
V
H
R
D
L
K
P
H
N
I
L
I
S
M
P
N
--------
A
H
--------
G
K
I
K
A
M
I
S
D
F
G
L
C
K
K
L
A
V
G
R
H
S
F
S
-----
P
G
T
E
G
W
I
A
P
E
M
L
S
-------------
N
P
T
Y
T
V
D
I
F
S
A
G
C
V
F
Y
Y
V
I
S
E
G
S
H
P
F
-
G
K
S
----
L
Q
R
Q
A
N
I
L
L
G
A
C
S
L
D
---
C
L
H
--
P
E
K
H
E
D
V
I
A
R
E
L
I
E
K
M
I
A
M
D
P
Q
K
R
P
S
A
K
H
V
L
K
H
P
F
F
W
S
L
E
K
Q
L
Q
F
F
Q
D
V
S
D
R
I
E
K
E
S
L
D
G
P
--
I
V
K
Q
L
E
R
G
G
R
A
V
V
-
K
M
-
D
W
R
E
N
I
T
V
P
L
Q
T
D
-------
K
G
G
S
V
R
D
L
L
R
A
M
R
N
K
K
H
H
Y
R
E
L
P
A
E
V
R
E
T
L
G
S
L
P
D
D
F
V
C
Y
F
T
S
R
F
P
H
L
L
A
H
T
Y
R
A
M
E
L
-
C
S
H
E
R
L
F
Q
P
Y
Y
F
H
--------------
23
PsiBlast_CBE
94.13
100%
-112
- C1 -
4Z7H
1
B:
[1-401]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
V
V
I
V
G
K
I
S
F
C
P
K
D
V
L
G
H
G
A
E
G
T
I
V
Y
-
R
G
M
F
D
N
R
D
V
A
V
K
R
I
L
P
E
C
F
S
F
A
D
-----
R
E
V
Q
L
L
R
E
S
D
E
H
P
N
V
I
R
Y
F
C
T
E
K
D
R
Q
F
Q
Y
I
A
I
E
L
C
A
A
--
T
L
Q
E
Y
V
E
Q
K
D
F
A
H
L
G
L
E
--
P
I
T
L
L
Q
Q
T
T
S
G
L
A
H
L
H
S
L
N
I
V
H
R
D
L
K
P
H
N
I
L
I
S
M
P
N
--------
A
H
--------
G
K
I
K
A
M
I
S
D
F
G
L
C
K
K
L
A
V
G
R
H
-------
V
P
G
T
E
G
W
I
A
P
E
M
L
S
--------------
P
T
Y
T
V
D
I
F
S
A
G
C
V
F
Y
Y
V
I
S
E
G
S
H
P
F
-
G
K
S
----
L
Q
R
Q
A
N
I
L
L
G
A
C
S
L
D
---
C
L
H
--
P
E
K
H
E
D
V
I
A
R
E
L
I
E
K
M
I
A
M
D
P
Q
K
R
P
S
A
K
H
V
L
K
H
P
F
F
W
S
L
E
K
Q
L
Q
F
F
Q
D
V
S
D
R
I
E
K
E
S
L
D
G
P
--
I
V
K
Q
L
E
R
G
G
R
A
V
V
-
K
M
-
D
W
R
E
N
I
T
V
P
L
Q
T
D
L
R
K
F
R
T
Y
K
G
G
S
V
R
D
L
L
R
A
M
R
N
K
K
H
H
Y
R
E
L
P
A
E
V
R
E
T
L
G
S
L
P
D
D
F
V
C
Y
F
T
S
R
F
P
H
L
L
A
H
T
Y
R
A
M
E
L
-
C
S
H
E
R
L
F
Q
P
Y
Y
F
---------------
2
PsiBlast_PDB
92.98
99%
-103
- C1 -
4U6R
3
A:
[39-441]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
S
V
V
I
V
G
K
I
S
F
C
P
K
D
V
L
G
H
G
A
E
G
T
I
V
Y
-
R
G
M
F
D
N
R
D
V
A
V
K
R
I
L
P
E
C
F
S
F
A
D
-----
R
E
V
Q
L
L
R
E
S
D
E
H
P
N
V
I
R
Y
F
C
T
E
K
D
R
Q
F
Q
Y
I
A
I
E
L
C
A
A
--
T
L
Q
E
Y
V
E
Q
K
D
F
A
H
L
G
L
E
--
P
I
T
L
L
Q
Q
T
T
S
G
L
A
H
L
H
S
L
N
I
V
H
R
D
L
K
P
H
N
I
L
I
S
M
P
N
--------
A
H
--------
G
K
I
K
A
M
I
S
D
F
G
L
C
K
K
L
A
V
G
R
H
S
F
S
R
R
S
G
V
P
G
T
E
G
W
I
A
P
E
M
L
S
E
D
----
C
----
K
E
N
P
T
Y
T
V
D
I
F
S
A
G
C
V
F
Y
Y
V
I
S
E
G
S
H
P
F
-
G
K
S
----
L
Q
R
Q
A
N
I
L
L
G
A
C
S
L
D
---
C
L
H
--
P
E
K
H
E
D
V
I
A
R
E
L
I
E
K
M
I
A
M
D
P
Q
K
R
P
S
A
K
H
V
L
K
H
P
F
F
W
S
L
E
K
Q
L
Q
F
F
Q
D
V
S
D
R
I
E
K
E
S
L
D
G
P
--
I
V
K
Q
L
E
R
G
G
R
A
V
V
-
K
M
-
D
W
R
E
N
I
T
V
P
L
Q
T
D
L
R
K
F
R
T
Y
K
G
G
S
V
R
D
L
L
R
A
M
R
N
K
K
H
H
Y
R
E
L
P
A
E
V
R
E
T
L
G
T
L
P
D
D
F
V
C
Y
F
T
S
R
F
P
H
L
L
A
H
T
Y
R
A
M
E
L
-
C
S
H
E
R
L
F
Q
P
Y
Y
F
H
--------------
43
Fugue
72.78
45%
-94
- C1 -
2RIO
1
IRE1_YEAST
A:
[8-434]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
F
E
Q
S
L
K
N
L
V
V
S
E
K
I
L
G
Y
G
S
S
G
T
V
V
F
-
Q
G
S
F
Q
G
R
P
V
A
V
K
R
M
L
I
D
F
C
D
I
A
L
-----
M
E
I
K
L
L
T
E
S
D
D
H
P
N
V
I
R
Y
Y
C
S
E
T
T
D
R
F
L
Y
I
A
L
E
L
C
N
L
--
N
L
Q
D
L
V
E
S
K
Y
------
N
--
P
I
S
L
L
R
Q
I
A
S
G
V
A
H
L
H
S
L
K
I
I
H
R
D
L
K
P
Q
N
I
L
V
S
T
S
S
--------
R
F
TADQQTGA
E
N
L
R
I
L
I
S
D
F
G
L
C
K
K
L
-------------
D
S
T
S
G
W
R
A
P
E
L
L
E
E
S
----
N
NLQT
K
R
R
L
T
R
S
I
D
I
F
S
M
G
C
V
F
Y
Y
I
L
S
K
G
K
H
P
F
-
G
D
K
----
Y
S
R
E
S
N
I
I
R
G
I
F
S
L
D
---
E
M
K
CL
H
D
R
S
L
I
A
E
A
T
D
L
I
S
Q
M
I
D
H
D
P
L
K
R
P
T
A
M
K
V
L
R
H
P
L
F
W
P
K
S
K
K
L
E
F
L
L
K
V
S
D
R
L
E
I
E
N
R
D
P
P
S
A
L
L
M
K
F
D
A
G
S
D
F
V
I
-
P
S
G
D
W
T
V
K
F
D
K
T
F
M
D
-----
R
K
Y
H
S
S
K
L
M
D
L
L
R
A
L
R
N
K
Y
H
H
F
M
D
L
P
E
D
I
A
E
L
M
G
P
V
P
D
G
F
Y
D
Y
F
T
K
R
F
P
N
L
L
I
G
V
Y
M
I
V
K
E
N
L
S
D
D
Q
I
L
R
E
F
L
Y
S
--------------
32
PsiBlast_CBE
70.44
45%
-96
- C1 -
2RIO
1
B:
[22-415]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
L
G
Y
G
S
S
G
T
V
V
F
-
Q
G
S
F
Q
G
R
P
V
A
V
K
R
M
L
I
D
F
C
D
I
A
L
-----
M
E
I
K
L
L
T
E
S
D
D
H
P
N
V
I
R
Y
Y
C
S
E
T
T
D
R
F
L
Y
I
A
L
E
L
C
N
L
--
N
L
Q
D
L
V
E
S
---------YN
P
I
S
L
L
R
Q
I
A
S
G
V
A
H
L
H
S
L
K
I
I
H
R
D
L
K
P
Q
N
I
L
V
S
T
S
S
RFTADQQT
G
A
--------
E
N
L
R
I
L
I
S
D
F
G
L
C
K
K
L
D
S
-------------
T
S
G
W
R
A
P
E
L
L
E
E
S
NNLQ
T
----
K
R
R
L
T
R
S
I
D
I
F
S
M
G
C
V
F
Y
Y
I
L
S
K
G
K
H
P
F
-
G
D
K
----
Y
S
R
E
S
N
I
I
R
G
I
F
S
L
D
EMK
C
L
H
---
D
R
S
L
I
A
E
A
T
D
L
I
S
Q
M
I
D
H
D
P
L
K
R
P
T
A
M
K
V
L
R
H
P
L
F
W
P
K
S
K
K
L
E
F
L
L
K
V
S
D
R
L
E
I
E
N
R
D
P
P
S
A
L
L
M
K
F
D
A
G
S
D
F
V
I
P
S
G
-
D
W
T
V
K
F
D
K
T
F
M
D
-----
R
K
Y
H
S
S
K
L
M
D
L
L
R
A
L
R
N
K
Y
H
H
F
M
D
L
P
E
D
I
A
E
L
M
G
P
V
P
D
G
F
Y
D
Y
F
T
K
R
F
P
N
L
L
I
G
V
Y
M
I
V
K
E
-
N
L
S
D
D
Q
I
L
R
E
F
L
Y
S
-------------
42
PsiBlast_CBE
38.29
31%
-78
- C1 -
2WEI
1
?
A:
[29-279]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
L
G
K
G
S
F
G
E
V
L
K
C
K
D
R
I
T
Q
Q
E
Y
A
V
K
V
I
N
K
A
S
A
K
N
K
D
T
S
T
I
L
R
E
V
E
L
L
K
K
L
D
-
H
P
N
I
M
K
L
F
E
I
L
E
D
S
S
S
F
Y
I
V
G
E
L
Y
T
G
GE
L
F
D
E
I
I
K
R
K
R
F
S
E
H
--
D
--
A
A
R
I
I
K
Q
V
F
S
G
I
T
Y
M
H
K
H
N
I
V
H
R
D
L
K
P
E
N
I
L
L
E
S
K
E
--------
K
D
--------
C
D
I
K
--
I
I
D
F
G
----
L
S
T
C
F
Q
Q
N
T
K
M
K
D
R
I
G
T
A
Y
Y
I
A
P
E
V
L
R
G
T
----
Y
----
D
E
K
----
C
D
V
W
S
A
G
V
I
L
Y
I
L
L
S
-
G
T
P
P
F
Y
G
K
N
E
Y
D
I
L
K
R
---
V
E
T
G
K
Y
A
F
D
---
L
P
Q
--
W
R
T
I
S
D
D
-
A
K
D
L
I
R
K
M
L
T
F
H
P
S
L
R
I
T
A
T
Q
C
L
E
H
P
W
I
Q
K
Y
S
S
E
------------------------------------------------------------------------------------------------------------------------------------------------