@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : FAK1_HUMAN: (2015-10-07 )
MAAAYLDPNLNHTPNSSTKTHLGTGMERSPGAMERVLKVFHYFESNSEPTTWASIIRHGDATDVRGIIQKIVDSHKVKHVACYGFRLSHLRSEEVHWLHVDMGVSSVREKYELAHPPEEWKYELRIRYLPKGFLNQFTEDKPTLNFFYQQVKSDYMLEIADQVDQEIALKLGCLEIRRSYWEMRGNALEKKSNYEVLEKDVGLKRFFPKSLLDSVKAKTLRKLIQQTFRQFANLNREESILKFFEILSPVYRFDKECFKCALGSSWIISVELAIGPEEGISYLTDKGCNPTHLADFTQVQTIQYSNSEDKDRKGMLQLKIAGAPEPLTVTAPSLTIAENMADLIDGYCRLVNGTSQSFIIRPQKEGERALPSIPKLANSEKQGMRTHAVSVSETDDYAEIIDEEDTYTMPSTRDYEIQRERIELGRCIGEGQFGDVHQGIYMSPENPALAVAIKTCKNCTSDSVREKFLQEALTMRQFDHPHIVKLIGVITENPVWIIMELCTLGELRSFLQVRKYSLDLASLILYAYQLSTALAYLESKRFVHRDIAARNVLVSSNDCVKLGDFGLSRYMEDSTYYKASKGKLPIKWMAPESINFRRFTSASDVWMFGVCMWEILMHGVKPFQGVKNNDVIGRIENGERLPMPPNCPPTLYSLMTKCWAYDPSRRPRFTELKAQLSTILEEEKAQQEERMRMESRRQATVSWDSGGSDEAPPKPSRPGYPSPRSSEGFYPSPQHMVQTNHYQVSGYPGSHGITAMAGSIYPGQASLLDQTDSWNHRPQEIAMWQPNVEDSTVLDLRGIGQVLPTHLMEERLIRQQQEMEEDQRWLEKEERFLKPDVRLSRGSIDREDGSLQGPIGNQHIYQPVGKPDPAAPPKKPPRPGAPGHLGSLASLSSPADSYNEGVKLQPQEISPPPTANLDRSNDKVYENVTGLVKAVIEMSSKIQPAPPEEYVPMVKEVGLALRTLLATVDETIPLLPASTHREIEMAQKLLNSDLGELINKMKLAQQYVMTSLQQEYKKQMLTAAHALAVDAKNLLDVIDQARLKMLGQTRPH
Atome Classification :
(90 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440-........450.....-..460.......470.......480.......490.-.-......500.......510.-...-....520.......530.......540.......550.......560.......570----.......580.......590.......600.......610.......620.....-..630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770.......780.......790.......800.......810.......820.......830.......840.......850.......860.......870.......880.......890.......900.......910.......920.......930.......940.......950.......960.......970.......980.......990.......1000......1010......1020......1030......1040......1050
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MA
A
A
YLDPNLNHTPNSSTKTHLGTGMERS
P
G
A
M
E
R
V
L
K
V
F
H
Y
F
ESNSEP
T
T
W
A
S
I
I
RHGD
A
T
D
V
R
G
I
I
Q
K
I
V
D
SHK
V
K
H
V
A
C
Y
G
F
R
L
S
HLRSEE
V
H
W
L
H
VDM
G
V
S
S
V
R
E
K
YELAHPPEE
W
K
Y
E
L
R
I
R
YL
P
K
G
F
L
N
Q
FTEDK
P
T
L
N
F
F
Y
Q
Q
VKS
D
Y
M
L
E
I
A
D
Q
V
D
Q
E
I
A
L
K
L
G
C
L
E
I
R
R
S
Y
W
E
MRGNALEKKS
N
Y
E
V
L
E
K
DV
G
L
K
R
F
F
P
K
S
L
L
D
S
V
K
A
K
T
L
R
K
L
I
Q
Q
T
F
R
Q
F
ANLN
R
E
E
S
I
L
K
F
F
E
I
L
S
P
V
Y
R
F
D
K
E
C
F
K
C
ALGS
S
W
I
I
S
V
E
L
A
IG
P
E
EG
I
S
Y
L
TDKGC
N
P
T
H
L
AD
F
T
Q
V
Q
T
I
Q
YSNSEDKDRK
G
M
L
Q
L
K
IAGAPE
P
L
T
V
TAP
S
L
T
I
A
E
N
M
A
D
L
I
D
G
Y
C
R
LVNGTSQ
S
F
I
IRPQKEGERALPSI
P
K
LANSEKQG
M
R
T
H
A
V
SVSETD
D
Y
A
E
I
IDEEDTYTMPSTR
D
Y
E
I
Q
R
E
R
I
E
L
G
R
CIGEGQFGDVHQ
G
I
Y
--MSPEN
P
A
L
A
V
A
I
K
T
C
K-NCT
S
D
S
V
R
E
K
F
L
Q
E
A
L
T
M
RQFDH
P
H
I
V
K
L
I
G
V
IT-E-N-
P
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
-
Q
-
V
R
K
-YS
L
D
L
A
S
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
VSSND
C
V
K
L
G
D
F
G
L
S
R
Y
ME----DS
T
Y
Y
KASKGKL
P
I
K
W
MAPESIN
F
R
RFTSA
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
HGVKPFQGVK-NN
D
V
I
G
RIENGERLPMPPNC
P
P
T
L
Y
S
L
M
T
K
C
WAYDPSRR
P
R
F
T
E
L
K
A
Q
L
S
T
I
L
E
E
E
K
A
Q
Q
E
E
R
M
R
M
E
S
RR
Q
A
T
V
SWDSGGSDEAPPKPSRPGYPSPRSSEGFYPSPQ
H
M
V
Q
TN
H
Y
Q
V
SGYPGSH
G
I
T
A
MAGSIYPGQ
A
S
LLDQTDSWNHRPQ
E
I
A
M
WQPNVEDS
T
V
L
D
L
R
G
I
G
Q
V
L
P
T
H
L
M
E
E
R
L
I
R
Q
Q
Q
E
M
E
E
D
Q
R
W
L
E
K
E
E
R
FLKPD
V
R
LSRGSIDREDGSLQGPIGNQHIYQPVGKPDPAAPPKKPPRPGAPGHL
G
S
L
ASLSSPADSYNEGVKLQPQEISPPPTANLDRSN
D
K
V
Y
E
N
V
T
G
L
V
K
A
V
I
E
M
SSKIQPA
P
P
E
E
Y
V
P
M
V
K
E
V
G
L
A
L
R
T
L
L
A
T
V
D
ETIPLLPAS
T
H
R
E
I
E
M
A
Q
K
L
L
N
S
D
L
G
E
L
I
N
K
M
K
L
A
Q
Q
Y
V
M
T
S
L
Q
Q
E
Y
K
K
Q
M
L
T
A
A
H
A
L
AV
D
A
K
N
L
L
D
V
I
D
Q
A
R
L
K
M
LGQTRPH
2
PsiBlast_PDB
94.99
96%
-134
- C2 -
2J0K
1
FAK1_CHICK
A:
[5-656]
----------------------------------
R
V
L
K
V
F
H
Y
F
E
N
S
S
E
P
T
T
W
A
S
I
I
R
H
G
D
A
T
D
V
R
G
I
I
Q
K
I
V
D
C
H
K
V
K
N
V
A
C
Y
G
L
R
L
S
H
L
Q
S
E
E
V
H
W
L
H
L
D
M
G
V
S
N
V
R
E
K
F
E
L
A
H
P
P
E
E
W
K
Y
E
L
R
I
R
Y
L
P
K
G
F
L
N
Q
F
T
E
D
K
P
T
L
N
F
F
Y
Q
Q
V
K
N
D
Y
M
L
E
I
A
D
Q
V
D
Q
E
I
A
L
K
L
G
C
L
E
I
R
R
S
Y
G
E
M
R
G
N
A
L
E
K
K
S
N
Y
E
V
L
E
K
D
V
G
L
R
R
F
F
P
K
S
L
L
D
S
V
K
A
K
T
L
R
K
L
I
Q
Q
T
F
R
Q
F
A
N
L
N
R
E
E
S
I
L
K
F
F
E
I
L
S
P
V
Y
R
F
D
K
E
C
F
K
C
A
L
G
S
S
W
I
I
S
V
E
L
A
I
G
P
E
E
G
I
S
Y
L
T
D
K
G
A
N
P
T
H
L
A
D
F
N
Q
V
Q
T
I
Q
Y
S
N
S
E
D
K
D
R
K
G
M
L
Q
L
K
I
A
G
A
P
E
P
L
T
V
T
A
P
S
L
T
I
A
E
N
M
A
D
L
I
D
G
Y
C
R
L
V
N
G
A
T
Q
S
F
I
I
R
P
-------------------------------
T
D
D
Y
A
E
I
I
D
E
--------
T
R
D
Y
E
I
Q
R
E
R
I
E
L
G
R
C
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
--
M
S
P
E
N
P
A
M
A
V
A
I
K
T
C
K
-
N
C
T
S
D
S
V
R
E
K
F
L
Q
E
A
L
T
M
R
Q
F
D
H
P
H
I
V
K
L
I
G
V
I
T
-
E
-
N
-
P
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
-
Q
-
V
R
K
-
F
S
L
D
L
A
S
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
A
T
D
C
V
K
L
G
D
F
G
L
-------------------
K
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
-
N
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
S
T
I
L
E
E
E
K
L
Q
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
94.22
96%
-127
- C2 -
2J0J
1
FAK1_CHICK
A:
[5-656]
----------------------------------
R
V
L
K
V
F
H
Y
F
E
N
S
S
E
P
T
T
W
A
S
I
I
R
H
G
D
A
T
D
V
R
G
I
I
Q
K
I
V
D
C
H
K
V
K
N
V
A
C
Y
G
L
R
L
S
H
L
Q
S
E
E
V
H
W
L
H
L
D
M
G
V
S
N
V
R
E
K
F
E
L
A
H
P
P
E
E
W
K
Y
E
L
R
I
R
Y
L
P
K
G
F
L
N
Q
F
T
E
D
K
P
T
L
N
F
F
Y
Q
Q
V
K
N
D
Y
M
L
E
I
A
D
Q
V
D
Q
E
I
A
L
K
L
G
C
L
E
I
R
R
S
Y
G
E
M
R
G
N
A
L
E
K
K
S
N
Y
E
V
L
E
K
D
V
G
L
R
R
F
F
P
K
S
L
L
D
S
V
K
A
K
T
L
R
K
L
I
Q
Q
T
F
R
Q
F
A
N
L
N
R
E
E
S
I
L
K
F
F
E
I
L
S
P
V
Y
R
F
D
K
E
C
F
K
C
A
L
G
S
S
W
I
I
S
V
E
L
A
I
G
P
E
E
G
I
S
Y
L
T
D
K
G
A
N
P
T
H
L
A
D
F
N
Q
V
Q
T
I
Q
Y
S
N
S
E
D
K
D
R
K
G
M
L
Q
L
K
I
A
G
A
P
E
P
L
T
V
T
A
P
S
L
T
I
A
E
N
M
A
D
L
I
D
G
Y
C
R
L
V
N
G
A
T
Q
S
F
I
I
R
P
-------------------------------
T
D
D
Y
A
E
I
I
D
E
E
D
T
Y
T
M
P
S
T
R
D
Y
E
I
Q
R
E
R
I
E
L
G
R
C
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
--
M
S
P
E
N
P
A
M
A
V
A
I
K
T
C
K
-
N
C
T
S
D
S
V
R
E
K
F
L
Q
E
A
L
T
M
R
Q
F
D
H
P
H
I
V
K
L
I
G
V
I
T
-
E
-
N
-
P
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
-
Q
-
V
R
K
-
F
S
L
D
L
A
S
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
S
N
D
C
V
K
L
G
D
F
G
L
S
R
Y
M
E
----
D
----------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
-
N
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
S
T
I
L
E
E
E
K
L
Q
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
93.50
96%
-128
- C2 -
2J0K
1
FAK1_CHICK
B:
[5-656]
----------------------------------
R
V
L
K
V
F
H
Y
F
E
N
S
S
E
P
T
T
W
A
S
I
I
R
H
G
D
A
T
D
V
R
G
I
I
Q
K
I
V
D
C
H
K
V
K
N
V
A
C
Y
G
L
R
L
S
H
L
Q
S
E
E
V
H
W
L
H
L
D
M
G
V
S
N
V
R
E
K
F
E
L
A
H
P
P
E
E
W
K
Y
E
L
R
I
R
Y
L
P
K
G
F
L
N
Q
F
T
E
D
K
P
T
L
N
F
F
Y
Q
Q
V
K
N
D
Y
M
L
E
I
A
D
Q
V
D
Q
E
I
A
L
K
L
G
C
L
E
I
R
R
S
Y
G
E
M
R
G
N
A
L
E
K
K
S
N
Y
E
V
L
E
K
D
V
G
L
R
R
F
F
P
K
S
L
L
D
S
V
K
A
K
T
L
R
K
L
I
Q
Q
T
F
R
Q
F
A
N
L
N
R
E
E
S
I
L
K
F
F
E
I
L
S
P
V
Y
R
F
D
K
E
C
F
K
C
A
L
G
S
S
W
I
I
S
V
E
L
A
I
G
P
E
E
G
I
S
Y
L
T
D
K
G
A
N
P
T
H
L
A
D
F
N
Q
V
Q
T
I
Q
Y
S
N
S
E
D
K
D
R
K
G
M
L
Q
L
K
I
A
G
A
P
E
P
L
T
V
T
A
P
S
L
T
I
A
E
N
M
A
D
L
I
D
G
Y
C
R
L
V
N
G
A
T
Q
S
F
I
I
R
P
--------------------
G
V
R
S
H
------
T
D
D
Y
A
E
I
I
D
E
E
D
T
Y
T
M
P
S
T
R
D
Y
E
I
Q
R
E
R
I
E
L
G
R
C
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
--
M
S
P
E
N
P
A
M
A
V
A
I
K
T
C
K
-
N
C
T
S
D
S
V
R
E
K
F
L
Q
E
A
L
T
M
R
Q
F
D
H
P
H
I
V
K
L
I
G
V
I
T
-
E
-
N
-
P
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
-
Q
-
V
R
K
-
F
S
L
D
L
A
S
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
A
T
D
C
V
K
L
G
D
F
G
L
S
R
------------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
-
N
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
S
T
I
L
E
E
E
K
L
Q
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
66.17
100%
-135
- C2 -
4KAB
1
FAK1_HUMAN
A:
[5-279]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
R
D
Y
E
I
Q
R
E
R
I
E
L
G
R
C
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
--
M
S
P
--
P
A
L
A
V
A
I
K
T
C
K
-
N
C
T
S
D
S
V
R
E
K
F
L
Q
E
A
L
T
M
R
Q
F
D
H
P
H
I
V
K
L
I
G
V
I
T
-
E
-
N
-
P
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
-
Q
-
V
R
K
-
Y
S
L
D
L
A
S
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
S
N
D
C
V
K
L
G
D
F
----------------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
-
N
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
S
T
I
L
E
E
E
K
A
Q
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
65.51
100%
-126
- C2 -
4I4E
1
A:
[9-281]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Y
E
I
Q
R
E
R
I
E
L
G
R
C
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
--
M
S
P
-
N
P
A
L
A
V
A
I
K
T
C
K
-
N
C
T
S
D
S
V
R
E
K
F
L
Q
E
A
L
T
M
R
Q
F
D
H
P
H
I
V
K
L
I
G
V
I
T
-
E
-
N
-
P
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
-
Q
-
V
R
K
-
Y
S
L
D
L
A
S
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
S
N
D
C
V
K
L
G
D
F
----------------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
-
N
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
S
T
I
L
E
E
E
K
A
Q
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
64.94
100%
-132
- C2 -
4GU9
1
FAK1_HUMAN
A:
[7-278]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Y
E
I
Q
R
E
R
I
E
L
G
R
C
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
--
M
S
P
--
P
A
L
A
V
A
I
K
T
C
K
-
N
C
T
S
D
S
V
R
E
K
F
L
Q
E
A
L
T
M
R
Q
F
D
H
P
H
I
V
K
L
I
G
V
I
T
-
E
-
N
-
P
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
-
Q
-
V
R
K
-
Y
S
L
D
L
A
S
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
S
N
D
C
V
K
L
G
D
F
----------------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
-
N
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
S
T
I
L
E
E
E
K
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
47
PsiBlast_CBE
64.93
98%
-127
- C2 -
4D4V
2
FAK1_CHICK
A:
[5-276]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
E
I
Q
R
E
R
I
E
L
G
R
C
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
--
M
S
P
E
N
P
A
M
A
V
A
I
K
T
C
K
-
N
C
T
S
D
S
V
R
E
K
F
L
Q
E
A
L
T
M
R
Q
F
D
H
P
H
I
V
K
L
I
G
V
I
T
-
E
-
N
-
P
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
-
Q
-
V
R
K
-
F
S
L
D
L
A
S
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
A
T
D
C
V
K
L
G
D
F
--------------------
G
K
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
-
N
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
S
T
I
L
E
E
E
K
L
Q
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
30
PsiBlast_CBE
64.89
100%
-128
- C2 -
4Q9S
1
A:
[9-281]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Y
E
I
Q
R
E
R
I
E
L
G
R
C
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
--
M
S
P
--
P
A
L
A
V
A
I
K
T
C
K
-
N
C
T
S
D
S
V
R
E
K
F
L
Q
E
A
L
T
M
R
Q
F
D
H
P
H
I
V
K
L
I
G
V
I
T
-
E
-
N
-
P
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
-
Q
-
V
R
K
-
Y
S
L
D
L
A
S
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
S
N
D
C
V
K
L
G
D
-----------------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
-
N
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
S
T
I
L
E
E
E
K
A
Q
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
PsiBlast_CBE
64.79
100%
-125
- C2 -
3PXK
1
B:
[7-280]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Y
E
I
Q
R
E
R
I
E
L
G
R
C
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
--
M
S
P
E
N
P
A
L
A
V
A
I
K
T
C
K
-
N
C
T
S
D
S
V
R
E
K
F
L
Q
E
A
L
T
M
R
Q
F
D
H
P
H
I
V
K
L
I
G
V
I
T
-
E
-
N
-
P
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
-
Q
-
V
R
K
-
Y
S
L
D
L
A
S
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
S
N
D
C
V
K
L
G
D
F
G
L
--------------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
-
N
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
S
T
I
L
E
E
E
K
A
Q
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
PsiBlast_CBE
64.70
100%
-126
- C2 -
4GU6
1
B:
[8-279]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
E
I
Q
R
E
R
I
E
L
G
R
C
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
--
M
S
P
E
N
P
A
L
A
V
A
I
K
T
C
K
-
N
C
T
S
D
S
V
R
E
K
F
L
Q
E
A
L
T
M
R
Q
F
D
H
P
H
I
V
K
L
I
G
V
I
T
-
E
-
N
-
P
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
-
Q
-
V
R
K
-
Y
S
L
D
L
A
S
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
S
N
D
C
V
K
L
G
D
F
G
L
S
R
------------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
-
N
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
S
T
I
L
E
E
E
K
A
Q
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
64.63
100%
-129
- C2 -
4KAO
1
FAK1_HUMAN
A:
[8-279]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
E
I
Q
R
E
R
I
E
L
G
R
C
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
--
M
S
P
---
A
L
A
V
A
I
K
T
C
K
-
N
C
T
S
D
S
V
R
E
K
F
L
Q
E
A
L
T
M
R
Q
F
D
H
P
H
I
V
K
L
I
G
V
I
T
-
E
-
N
-
P
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
-
Q
-
V
R
K
-
Y
S
L
D
L
A
S
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
S
N
D
C
V
K
L
G
D
F
G
---------------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
-
N
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
S
T
I
L
E
E
E
K
A
Q
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
53
PsiBlast_CBE
64.60
98%
-124
- C2 -
2JKO
1
A:
[5-276]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
E
I
Q
R
E
R
I
E
L
G
R
C
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
--
M
S
P
E
N
P
A
M
A
V
A
I
K
T
C
K
-
N
C
T
S
D
S
V
R
E
K
F
L
Q
E
A
L
T
M
R
Q
F
D
H
P
H
I
V
K
L
I
G
V
I
T
-
E
-
N
-
P
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
-
Q
-
V
R
K
-
F
S
L
D
L
A
S
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
A
T
D
C
V
K
L
G
D
F
G
L
--------------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
-
N
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
S
T
I
L
E
E
E
K
L
Q
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
51
PsiBlast_CBE
64.54
98%
-124
- C2 -
4C7T
1
A:
[4-274]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Y
E
I
Q
R
E
R
I
E
L
G
R
C
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
--
M
S
P
E
N
P
A
M
A
V
A
I
K
T
C
K
-
N
C
T
S
D
S
V
R
E
K
F
L
Q
E
A
L
T
M
R
Q
F
D
H
P
H
I
V
K
L
I
G
V
I
T
-
E
-
N
-
P
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
-
Q
-
V
R
K
-
F
S
L
D
L
A
S
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
A
T
D
C
V
K
L
G
D
F
G
L
S
R
Y
M
----------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
-
N
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
S
T
I
L
E
E
E
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
64.51
100%
-129
- C2 -
3PXK
1
FAK1_HUMAN
A:
[8-280]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
E
I
Q
R
E
R
I
E
L
G
R
C
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
--
M
S
P
E
N
P
A
L
A
V
A
I
K
T
C
K
-
N
C
T
S
D
S
V
R
E
K
F
L
Q
E
A
L
T
M
R
Q
F
D
H
P
H
I
V
K
L
I
G
V
I
T
-
E
-
N
-
P
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
-
Q
-
V
R
K
-
Y
S
L
D
L
A
S
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
S
N
D
C
V
K
L
G
D
F
G
---------------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
-
N
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
S
T
I
L
E
E
E
K
A
Q
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
PsiBlast_CBE
64.45
100%
-129
- C2 -
4KAO
1
B:
[7-279]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Y
E
I
Q
R
E
R
I
E
L
G
R
C
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
--
M
S
P
--
P
A
L
A
V
A
I
K
T
C
K
-
N
C
T
S
D
S
V
R
E
K
F
L
Q
E
A
L
T
M
R
Q
F
D
H
P
H
I
V
K
L
I
G
V
I
T
-
E
-
N
-
P
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
-
Q
-
V
R
K
-
Y
S
L
D
L
A
S
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
S
N
D
C
V
K
L
G
D
F
G
---------------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
-
N
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
S
T
I
L
E
E
E
K
A
Q
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
64.28
100%
-123
- C2 -
1MP8
1
A:
[9-281]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Y
E
I
Q
R
E
R
I
E
L
G
R
C
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
--
M
S
P
--
P
A
L
A
V
A
I
K
T
C
K
-
N
C
T
S
D
S
V
R
E
K
F
L
Q
E
A
L
T
M
R
Q
F
D
H
P
H
I
V
K
L
I
G
V
I
T
-
E
-
N
-
P
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
-
Q
-
V
R
K
-
Y
S
L
D
L
A
S
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
S
N
D
C
V
K
L
G
D
-----------------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
-
N
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
S
T
I
L
E
E
E
K
A
Q
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
40
PsiBlast_CBE
64.25
98%
-128
- C2 -
4D5H
1
FAK1_CHICK
A:
[5-276]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
E
I
Q
R
E
R
I
E
L
G
R
C
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
--
M
S
P
E
N
P
A
M
A
V
A
I
K
T
C
K
-
N
C
T
S
D
S
V
R
E
K
F
L
Q
E
A
L
T
M
R
Q
F
D
H
P
H
I
V
K
L
I
G
V
I
T
-
E
-
N
-
P
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
-
Q
-
V
R
K
-
F
S
L
D
L
A
S
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
A
T
D
C
V
K
L
G
D
F
---------------------
K
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
-
N
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
S
T
I
L
E
E
E
K
L
Q
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
35
PsiBlast_CBE
64.25
99%
-129
- C2 -
2J0M
1
?
B:
[4-276]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Y
E
I
Q
R
E
R
I
E
L
G
R
C
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
--
M
S
P
E
N
P
A
L
A
V
A
I
K
T
C
K
-
N
C
T
S
D
S
V
R
E
K
F
L
Q
E
A
L
T
M
R
Q
F
D
H
P
H
I
V
K
L
I
G
V
I
T
-
E
-
N
-
P
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
-
Q
-
V
R
K
-
Y
S
L
D
L
A
S
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
S
N
D
C
V
K
L
G
D
F
G
L
--------------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
-
N
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
S
T
I
L
E
E
E
K
L
Q
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
33
PsiBlast_CBE
64.19
100%
-124
- C2 -
4EBV
3
A:
[29-304]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
T
R
D
Y
E
I
Q
R
E
R
I
E
L
G
R
C
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
--
M
S
P
E
N
P
A
L
A
V
A
I
K
T
C
K
-
N
C
T
S
D
S
V
R
E
K
F
L
Q
E
A
L
T
M
R
Q
F
D
H
P
H
I
V
K
L
I
G
V
I
T
-
E
-
N
-
P
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
-
Q
-
V
R
K
-
Y
S
L
D
L
A
S
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
S
N
D
C
V
K
L
G
D
F
G
L
-------------------
K
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
-
N
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
S
T
I
L
E
E
E
K
A
Q
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
34
PsiBlast_CBE
64.17
99%
-124
- C2 -
2JKQ
1
A:
[4-276]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Y
E
I
Q
R
E
R
I
E
L
G
R
C
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
--
M
S
P
E
N
P
A
L
A
V
A
I
K
T
C
K
-
N
C
T
S
D
S
V
R
E
K
F
L
Q
E
A
L
T
M
R
Q
F
D
H
P
H
I
V
K
L
I
G
V
I
T
-
E
-
N
-
P
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
-
Q
-
V
R
K
-
Y
S
L
D
L
A
S
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
S
N
D
C
V
K
L
G
D
F
G
L
S
-------------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
-
N
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
S
T
I
L
E
E
E
K
L
Q
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
54
PsiBlast_CBE
64.16
98%
-123
- C2 -
2JKK
1
?
A:
[3-274]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
Y
E
I
Q
R
E
R
I
E
L
G
R
C
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
--
M
S
P
E
N
P
A
M
A
V
A
I
K
T
C
K
-
N
C
T
S
D
S
V
R
E
K
F
L
Q
E
A
L
T
M
R
Q
F
D
H
P
H
I
V
K
L
I
G
V
I
T
-
E
-
N
-
P
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
-
Q
-
V
R
K
-
F
S
L
D
L
A
S
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
A
T
D
C
V
K
L
G
D
F
G
L
S
R
------------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
-
N
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
S
T
I
L
E
E
E
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
63.98
100%
-124
- C2 -
2IJM
1
B:
[6-281]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Y
E
I
Q
R
E
R
I
E
L
G
R
C
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
--
M
S
P
E
N
P
A
L
A
V
A
I
K
T
C
K
-
N
C
T
S
D
S
V
R
E
K
F
L
Q
E
A
L
T
M
R
Q
F
D
H
P
H
I
V
K
L
I
G
V
I
T
-
E
-
N
-
P
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
-
Q
-
V
R
K
-
Y
S
L
D
L
A
S
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
S
N
D
C
V
K
L
G
D
F
G
L
S
-------------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
-
N
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
S
T
I
L
E
E
E
K
A
Q
Q
E
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
PsiBlast_CBE
63.88
100%
-126
- C2 -
4KAB
1
B:
[7-277]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Y
E
I
Q
R
E
R
I
E
L
G
R
C
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
--
M
S
P
E
-
P
A
L
A
V
A
I
K
T
C
K
-
N
C
T
S
D
S
V
R
E
K
F
L
Q
E
A
L
T
M
R
Q
F
D
H
P
H
I
V
K
L
I
G
V
I
T
-
E
-
N
-
P
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
-
Q
-
V
R
K
-
Y
S
L
D
L
A
S
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
S
N
D
C
V
K
L
G
D
F
G
L
S
R
Y
M
----------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
-
N
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
S
T
I
L
E
E
E
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
36
PsiBlast_CBE
63.77
99%
-123
- C2 -
2JKM
1
A:
[3-276]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
Y
E
I
Q
R
E
R
I
E
L
G
R
C
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
--
M
S
P
E
N
P
A
M
A
V
A
I
K
T
C
K
-
N
C
T
S
D
S
V
R
E
K
F
L
Q
E
A
L
T
M
R
Q
F
D
H
P
H
I
V
K
L
I
G
V
I
T
-
E
-
N
-
P
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
-
Q
-
V
R
K
-
Y
S
L
D
L
A
S
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
S
N
D
C
V
K
L
G
D
F
G
L
S
R
------------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
-
N
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
S
T
I
L
E
E
E
K
L
Q
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
63.76
100%
-121
- C2 -
2IJM
1
FAK1_HUMAN
A:
[6-280]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Y
E
I
Q
R
E
R
I
E
L
G
R
C
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
--
M
S
P
E
N
P
A
L
A
V
A
I
K
T
C
K
-
N
C
T
S
D
S
V
R
E
K
F
L
Q
E
A
L
T
M
R
Q
F
D
H
P
H
I
V
K
L
I
G
V
I
T
-
E
-
N
-
P
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
-
Q
-
V
R
K
-
Y
S
L
D
L
A
S
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
S
N
D
C
V
K
L
G
D
F
G
L
S
-------------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
-
N
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
S
T
I
L
E
E
E
K
A
Q
Q
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
41
PsiBlast_CBE
63.67
98%
-124
- C2 -
4D58
1
?
B:
[4-276]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Y
E
I
Q
R
E
R
I
E
L
G
R
C
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
--
M
S
P
E
N
P
A
M
A
V
A
I
K
T
C
K
-
N
C
T
S
D
S
V
R
E
K
F
L
Q
E
A
L
T
M
R
Q
F
D
H
P
H
I
V
K
L
I
G
V
I
T
-
E
-
N
-
P
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
-
Q
-
V
R
K
-
F
S
L
D
L
A
S
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
A
T
D
C
V
K
L
G
D
F
G
L
S
R
Y
M
----------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
-
N
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
S
T
I
L
E
E
E
K
L
Q
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
48
PsiBlast_CBE
63.64
98%
-123
- C2 -
4D4S
1
B:
[5-276]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
E
I
Q
R
E
R
I
E
L
G
R
C
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
--
M
S
P
E
N
P
A
M
A
V
A
I
K
T
C
K
-
N
C
T
S
D
S
V
R
E
K
F
L
Q
E
A
L
T
M
R
Q
F
D
H
P
H
I
V
K
L
I
G
V
I
T
-
E
-
N
-
P
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
-
Q
-
V
R
K
-
F
S
L
D
L
A
S
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
A
T
D
C
V
K
L
G
D
F
G
L
S
R
Y
M
----------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
-
N
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
S
T
I
L
E
E
E
K
L
Q
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
32
PsiBlast_CBE
63.58
100%
-124
- C2 -
4EBW
1
A:
[29-304]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
T
R
D
Y
E
I
Q
R
E
R
I
E
L
G
R
C
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
--
M
S
--
N
P
A
L
A
V
A
I
K
T
C
K
-
N
C
T
S
D
S
V
R
E
K
F
L
Q
E
A
L
T
M
R
Q
F
D
H
P
H
I
V
K
L
I
G
V
I
T
-
E
-
N
-
P
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
-
Q
-
V
R
K
-
Y
S
L
D
L
A
S
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
S
N
D
C
V
K
L
G
D
F
G
L
-------------------
K
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
-
N
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
S
T
I
L
E
E
E
K
A
Q
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
31
PsiBlast_CBE
63.56
100%
-120
- C2 -
3BZ3
1
A:
[1-276]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Y
E
I
Q
R
E
R
I
E
L
G
R
C
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
--
M
S
P
----
L
A
V
A
I
K
T
C
K
-
N
C
T
S
D
S
V
R
E
K
F
L
Q
E
A
L
T
M
R
Q
F
D
H
P
H
I
V
K
L
I
G
V
I
T
-
E
-
N
-
P
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
-
Q
-
V
R
K
-
Y
S
L
D
L
A
S
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
S
N
D
C
V
K
L
G
D
F
G
L
S
R
Y
-----------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
-
N
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
S
T
I
L
E
E
E
K
A
Q
Q
E
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
46
PsiBlast_CBE
63.35
98%
-125
- C2 -
4D4V
2
B:
[5-276]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
E
I
Q
R
E
R
I
E
L
G
R
C
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
--
M
S
P
E
N
P
A
M
A
V
A
I
K
T
C
K
-
N
C
T
S
D
S
V
R
E
K
F
L
Q
E
A
L
T
M
R
Q
F
D
H
P
H
I
V
K
L
I
G
V
I
T
-
E
-
N
-
P
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
-
Q
-
V
R
K
-
F
S
L
D
L
A
S
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
A
T
D
C
V
K
L
G
D
F
G
---------------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
-
N
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
S
T
I
L
E
E
E
K
L
Q
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
63.34
100%
-127
- C2 -
4K8A
1
FAK1_HUMAN
A:
[7-276]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Y
E
I
Q
R
E
R
I
E
L
G
R
C
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
--
M
S
P
--
P
A
L
A
V
A
I
K
T
C
K
-
N
C
T
S
D
S
V
R
E
K
F
L
Q
E
A
L
T
M
R
Q
F
D
H
P
H
I
V
K
L
I
G
V
I
T
-
E
-
N
-
P
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
-
Q
-
V
R
K
-
Y
S
L
D
L
A
S
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
S
N
D
C
V
K
L
G
D
F
G
---------------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
-
N
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
S
T
I
L
E
E
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
29
PsiBlast_CBE
63.22
100%
-127
- C2 -
4GU9
1
B:
[8-276]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
E
I
Q
R
E
R
I
E
L
G
R
C
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
--
M
S
P
--
P
A
L
A
V
A
I
K
T
C
K
-
N
C
T
S
D
S
V
R
E
K
F
L
Q
E
A
L
T
M
R
Q
F
D
H
P
H
I
V
K
L
I
G
V
I
T
-
E
-
N
-
P
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
-
Q
-
V
R
K
-
Y
S
L
D
L
A
S
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
S
N
D
C
V
K
L
G
D
F
G
L
S
R
Y
M
----------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
-
N
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
S
T
I
L
E
E
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28
PsiBlast_CBE
63.16
100%
-121
- C2 -
4K8A
1
B:
[7-277]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Y
E
I
Q
R
E
R
I
E
L
G
R
C
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
--
M
S
P
E
N
P
A
L
A
V
A
I
K
T
C
K
-
N
C
T
S
D
S
V
R
E
K
F
L
Q
E
A
L
T
M
R
Q
F
D
H
P
H
I
V
K
L
I
G
V
I
T
-
E
-
N
-
P
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
-
Q
-
V
R
K
-
Y
S
L
D
L
A
S
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
S
N
D
C
V
K
L
G
D
F
G
L
S
R
Y
-----------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
-
N
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
S
T
I
L
E
E
E
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
PsiBlast_CBE
63.11
100%
-119
- C2 -
2ETM
1
B:
[5-281]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
Y
E
I
Q
R
E
R
I
E
L
G
R
C
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
--
M
S
P
E
N
P
A
L
A
V
A
I
K
T
C
K
-
N
C
T
S
D
S
V
R
E
K
F
L
Q
E
A
L
T
M
R
Q
F
D
H
P
H
I
V
K
L
I
G
V
I
T
-
E
-
N
-
P
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
-
Q
-
V
R
K
-
Y
S
L
D
L
A
S
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
S
N
D
C
V
K
L
G
D
F
G
L
S
R
------------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
-
N
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
S
T
I
L
E
E
E
K
A
Q
Q
E
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
62.92
100%
-122
- C2 -
2ETM
1
FAK1_HUMAN
A:
[7-278]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
E
I
Q
R
E
R
I
E
L
G
R
C
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
--
M
S
P
E
N
P
A
L
A
V
A
I
K
T
C
K
-
N
C
T
S
D
S
V
R
E
K
F
L
Q
E
A
L
T
M
R
Q
F
D
H
P
H
I
V
K
L
I
G
V
I
T
-
E
-
N
-
P
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
-
Q
-
V
R
K
-
Y
S
L
D
L
A
S
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
S
N
D
C
V
K
L
G
D
F
G
L
S
R
Y
M
E
--------------
K
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
-
N
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
S
T
I
L
E
E
E
K
A
Q
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
55
PsiBlast_CBE
62.55
98%
-120
- C2 -
2J0L
1
A:
[1-276]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
T
R
D
Y
E
I
Q
R
E
R
I
E
L
G
R
C
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
--
M
S
P
E
N
P
A
M
A
V
A
I
K
T
C
K
-
N
C
T
S
D
S
V
R
E
K
F
L
Q
E
A
L
T
M
R
Q
F
D
H
P
H
I
V
K
L
I
G
V
I
T
-
E
-
N
-
P
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
-
Q
-
V
R
K
-
F
S
L
D
L
A
S
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
S
N
D
C
V
K
L
G
D
F
G
L
S
R
Y
M
E
----
D
S
T
Y
Y
K
A
S
K
G
K
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
-
N
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
S
T
I
L
E
E
E
K
L
Q
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
62.55
100%
-124
- C2 -
4I4F
2
A:
[10-281]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
E
I
Q
R
E
R
I
E
L
G
R
C
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
--
M
S
P
---
A
L
A
V
A
I
K
T
C
K
-
N
C
T
S
D
S
V
R
E
K
F
L
Q
E
A
L
T
M
R
Q
F
D
H
P
H
I
V
K
L
I
G
V
I
T
-
E
-
N
-
P
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
-
Q
-
V
R
K
-
Y
S
L
D
L
A
S
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
S
N
D
C
V
K
L
G
D
F
G
L
S
------------------
K
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
-
N
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
S
T
I
L
E
E
E
K
A
Q
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
61.30
100%
-119
- C2 -
4K9Y
1
A:
[8-278]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
E
I
Q
R
E
R
I
E
L
G
R
C
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
--
M
S
P
E
N
P
A
L
A
V
A
I
K
T
C
K
-
N
C
T
S
D
S
V
R
E
K
F
L
Q
E
A
L
T
M
R
Q
F
D
H
P
H
I
V
K
L
I
G
V
I
T
-
E
-
N
-
P
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
-
Q
-
V
R
K
-
Y
S
L
D
L
A
S
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
S
N
D
C
V
K
L
G
D
F
G
L
S
R
Y
M
E
----
D
S
T
Y
Y
K
A
S
K
G
K
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
-
N
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
S
T
I
L
E
E
E
K
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
60.53
100%
-116
- C2 -
4GU6
1
FAK1_HUMAN
A:
[7-279]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Y
E
I
Q
R
E
R
I
E
L
G
R
C
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
--
M
S
--
N
P
A
L
A
V
A
I
K
T
C
K
-
N
C
T
S
D
S
V
R
E
K
F
L
Q
E
A
L
T
M
R
Q
F
D
H
P
H
I
V
K
L
I
G
V
I
T
-
E
-
N
-
P
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
-
Q
-
V
R
K
-
Y
S
L
D
L
A
S
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
S
N
D
C
V
K
L
G
D
F
G
L
S
R
Y
M
E
----
D
S
T
Y
Y
K
A
S
K
G
K
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
-
N
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
S
T
I
L
E
E
E
K
A
Q
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
58
PsiBlast_CBE
57.03
60%
-121
- C2 -
3FZS
1
A:
[5-272]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
A
R
E
D
V
V
L
N
R
I
L
G
E
G
F
F
G
E
V
Y
E
G
V
Y
--
T
N
H
K
G
E
K
I
N
V
A
V
K
T
C
K
K
D
C
T
L
D
N
-
K
E
K
F
M
S
E
A
V
I
M
K
N
L
D
H
P
H
I
V
K
L
I
G
I
I
E
-
E
-
E
-
P
T
W
I
I
M
E
L
Y
P
Y
G
E
L
G
H
Y
L
-
E
-
R
N
K
-
N
S
L
K
V
L
T
L
V
L
Y
S
L
Q
I
C
K
A
M
A
Y
L
E
S
I
N
C
V
H
R
D
I
A
V
R
N
I
L
V
A
S
P
E
C
V
K
L
G
D
F
G
---------------------
L
P
I
K
W
M
S
P
E
S
I
N
F
R
R
F
T
T
A
S
D
V
W
M
F
A
V
C
M
W
E
I
L
S
F
G
K
Q
P
F
F
W
L
E
-
N
K
D
V
I
G
V
L
E
K
G
D
R
L
P
K
P
D
L
C
P
P
V
L
Y
T
L
M
T
R
C
W
D
Y
D
P
S
D
R
P
R
F
T
E
L
V
C
S
L
S
D
V
Y
Q
M
E
K
D
I
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
60
PsiBlast_CBE
56.57
60%
-118
- C2 -
3FZP
1
A:
[4-272]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
I
A
R
E
D
V
V
L
N
R
I
L
G
E
G
F
F
G
E
V
Y
E
G
V
Y
--
T
N
H
K
G
E
K
I
N
V
A
V
K
T
C
K
K
D
C
T
L
D
N
-
K
E
K
F
M
S
E
A
V
I
M
K
N
L
D
H
P
H
I
V
K
L
I
G
I
I
E
-
E
-
E
-
P
T
W
I
I
M
E
L
Y
P
Y
G
E
L
G
H
Y
L
-
E
-
R
N
K
-
N
S
L
K
V
L
T
L
V
L
Y
S
L
Q
I
C
K
A
M
A
Y
L
E
S
I
N
C
V
H
R
D
I
A
V
R
N
I
L
V
A
S
P
E
C
V
K
L
G
D
F
G
-------------------
T
R
L
P
I
K
W
M
S
P
E
S
I
N
F
R
R
F
T
T
A
S
D
V
W
M
F
A
V
C
M
W
E
I
L
S
F
G
K
Q
P
F
F
W
L
E
-
N
K
D
V
I
G
V
L
E
K
G
D
R
L
P
K
P
D
L
C
P
P
V
L
Y
T
L
M
T
R
C
W
D
Y
D
P
S
D
R
P
R
F
T
E
L
V
C
S
L
S
D
V
Y
Q
M
E
K
D
I
A
M
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
62
PsiBlast_CBE
56.44
60%
-122
- C2 -
4H1M
1
A:
[21-288]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
A
R
E
D
V
V
L
N
R
I
L
G
E
G
F
F
G
E
V
Y
E
G
V
Y
--
T
N
H
K
G
E
K
I
N
V
A
V
K
T
C
K
K
D
C
T
L
D
N
-
K
E
K
F
M
S
E
A
V
I
M
K
N
L
D
H
P
H
I
V
K
L
I
G
I
I
E
-
E
-
E
-
P
T
W
I
I
M
E
L
Y
P
Y
G
E
L
G
H
Y
L
-
E
-
R
N
K
-
N
S
L
K
V
L
T
L
V
L
Y
S
L
Q
I
C
K
A
M
A
Y
L
E
S
I
N
C
V
H
R
D
I
A
V
R
N
I
L
V
A
S
P
E
C
V
K
L
G
D
F
G
L
S
-------------------
L
P
I
K
W
M
S
P
E
S
I
N
F
R
R
F
T
T
A
S
D
V
W
M
F
A
V
C
M
W
E
I
L
S
F
G
K
Q
P
F
F
W
L
E
-
N
K
D
V
I
G
V
L
E
K
G
D
R
L
P
K
P
D
L
C
P
P
V
L
Y
T
L
M
T
R
C
W
D
Y
D
P
S
D
R
P
R
F
T
E
L
V
C
S
L
S
D
V
Y
Q
M
E
K
D
I
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
63
PsiBlast_CBE
55.37
60%
-115
- C2 -
4H1J
1
A:
[20-288]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
I
A
R
E
D
V
V
L
N
R
I
L
G
E
G
F
F
G
E
V
Y
E
G
V
Y
--
T
N
H
K
G
E
K
I
N
V
A
V
K
T
C
K
K
D
C
T
L
D
N
-
K
E
K
F
M
S
E
A
V
I
M
K
N
L
D
H
P
H
I
V
K
L
I
G
I
I
E
-
E
-
E
-
P
T
W
I
I
M
E
L
Y
P
Y
G
E
L
G
H
Y
L
-
E
-
R
N
K
-
N
S
L
K
V
L
T
L
V
L
Y
S
L
Q
I
C
K
A
M
A
Y
L
E
S
I
N
C
V
H
R
D
I
A
V
R
N
I
L
V
A
S
P
E
C
V
K
L
G
D
F
G
L
S
R
-------
D
E
------
V
T
R
L
P
I
K
W
M
S
P
E
S
I
N
F
R
R
F
T
T
A
S
D
V
W
M
F
A
V
C
M
W
E
I
L
S
F
G
K
Q
P
F
F
W
L
E
-
N
K
D
V
I
G
V
L
E
K
G
D
R
L
P
K
P
D
L
C
P
P
V
L
Y
T
L
M
T
R
C
W
D
Y
D
P
S
D
R
P
R
F
T
E
L
V
C
S
L
S
D
V
Y
Q
M
E
K
D
I
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
115
PsiBlast_CBE
54.80
41%
-110
- C2 -
2VX0
1
A:
[12-281]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
D
V
S
Y
V
K
I
E
E
V
I
G
A
G
E
F
G
E
V
C
R
G
R
L
--
K
A
P
G
K
K
E
S
C
V
A
I
K
T
L
K
-
G
G
Y
T
E
R
Q
R
R
E
F
L
S
E
A
S
I
M
G
Q
F
E
H
P
N
I
I
R
L
E
G
V
V
T
-
N
-
S
M
P
V
M
I
L
T
E
F
M
E
N
G
A
L
D
S
F
L
-
R
-
L
N
D
-
G
Q
F
T
V
I
Q
L
V
G
M
L
R
G
I
A
S
G
M
R
Y
L
A
E
M
S
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
S
R
F
L
E
ENSS
D
--------
G
K
I
P
I
R
W
T
A
P
E
A
I
A
F
R
K
F
T
S
A
S
D
A
W
S
Y
G
I
V
M
W
E
V
M
S
F
G
E
R
P
Y
W
D
M
S
-
N
Q
D
V
I
N
A
I
E
Q
D
Y
R
L
P
P
P
P
D
C
P
T
S
L
H
Q
L
M
L
D
C
W
Q
K
D
R
N
A
R
P
R
F
P
Q
V
V
S
A
L
D
K
M
I
R
N
P
A
S
L
K
I
V
A
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
112
PsiBlast_CBE
54.63
41%
-114
- C2 -
4BB4
1
A:
[12-281]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
D
V
S
Y
V
K
I
E
E
V
I
G
A
G
E
F
G
E
V
C
R
G
R
L
--
K
A
P
G
K
K
E
S
C
V
A
I
K
T
L
----
Y
T
E
R
Q
R
R
E
F
L
S
E
A
S
I
M
G
Q
F
E
H
P
N
I
I
R
L
E
G
V
V
T
-
N
-
S
M
P
V
M
I
L
T
E
F
M
E
N
G
A
L
D
S
F
L
-
R
-
L
N
D
-
G
Q
F
T
V
I
Q
L
V
G
M
L
R
G
I
A
S
G
M
R
Y
L
A
E
M
S
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
S
R
F
---------------
G
K
I
P
I
R
W
T
A
P
E
A
I
A
F
R
K
F
T
S
A
S
D
A
W
S
Y
G
I
V
M
W
E
V
M
S
F
G
E
R
P
Y
W
D
M
S
-
N
Q
D
V
I
N
A
I
E
Q
D
Y
R
L
P
P
P
P
D
C
P
T
S
L
H
Q
L
M
L
D
C
W
Q
K
D
R
N
A
R
P
R
F
P
Q
V
V
S
A
L
D
K
M
I
R
N
P
A
S
L
K
I
V
A
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
57
PsiBlast_CBE
54.60
60%
-116
- C2 -
3FZT
1
A:
[5-272]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
A
R
E
D
V
V
L
N
R
I
L
G
E
G
F
F
G
E
V
Y
E
G
V
Y
--
T
N
H
K
G
E
K
I
N
V
A
V
K
T
C
K
K
D
C
T
L
D
N
-
K
E
K
F
M
S
E
A
V
I
M
K
N
L
D
H
P
H
I
V
K
L
I
G
I
I
E
-
E
-
E
-
P
T
W
I
I
M
E
L
Y
P
Y
G
E
L
G
H
Y
L
-
E
-
R
N
K
-
N
S
L
K
V
L
T
L
V
L
Y
S
L
Q
I
C
K
A
M
A
Y
L
E
S
I
N
C
V
H
R
D
I
A
V
R
N
I
L
V
A
S
P
E
C
V
K
L
G
D
F
G
L
S
R
-------
D
E
---------
L
P
I
K
W
M
S
P
E
S
I
N
F
R
R
F
T
T
A
S
D
V
W
M
F
A
V
C
M
W
E
I
L
S
F
G
K
Q
P
F
F
W
L
E
-
N
K
D
V
I
G
V
L
E
K
G
D
R
L
P
K
P
D
L
C
P
P
V
L
Y
T
L
M
T
R
C
W
D
Y
D
P
S
D
R
P
R
F
T
E
L
V
C
S
L
S
D
V
Y
Q
M
E
K
D
I
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
95
PsiBlast_CBE
54.56
42%
-113
- C2 -
1JPA
1
EPHB2_MOUSE
A:
[29-298]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
D
I
S
C
V
K
I
E
Q
V
I
G
A
G
E
F
G
E
V
C
S
G
H
L
--
K
L
---
R
E
I
F
V
A
I
K
T
L
K
-
S
G
Y
T
E
K
Q
R
R
D
F
L
S
E
A
S
I
M
G
Q
F
D
H
P
N
V
I
H
L
E
G
V
V
T
-
K
-
S
T
P
V
M
I
I
T
E
F
M
E
N
G
S
L
D
S
F
L
-
R
-
Q
N
D
-
G
Q
F
T
V
I
Q
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
D
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
-----------------------
P
I
R
W
T
A
P
E
A
I
Q
Y
R
K
F
T
S
A
S
D
V
W
S
Y
G
I
V
M
W
E
V
M
S
Y
G
E
R
P
Y
W
D
M
T
-
N
Q
D
V
I
N
A
I
E
Q
D
Y
R
L
P
P
P
M
D
C
P
S
A
L
H
Q
L
M
L
D
C
W
Q
K
D
R
N
H
R
P
K
F
G
Q
I
V
N
T
L
D
K
M
I
R
N
P
N
S
L
K
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
114
PsiBlast_CBE
54.51
41%
-112
- C2 -
2VX1
1
A:
[12-281]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
D
V
S
Y
V
K
I
E
E
V
I
G
A
G
E
F
G
E
V
C
R
G
R
L
--
K
A
P
G
K
K
E
S
C
V
A
I
K
T
L
K
-
G
G
Y
T
E
R
Q
R
R
E
F
L
S
E
A
S
I
M
G
Q
F
E
H
P
N
I
I
R
L
E
G
V
V
T
-
N
-
S
M
P
V
M
I
L
T
E
F
M
E
N
G
A
L
D
S
F
L
-
R
-
L
N
D
-
G
Q
F
T
V
I
Q
L
V
G
M
L
R
G
I
A
S
G
M
R
Y
L
A
E
M
S
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
S
R
F
L
E
ENSS
D
-------
G
G
K
I
P
I
R
W
T
A
P
E
A
I
A
F
R
K
F
T
S
A
S
D
A
W
S
Y
G
I
V
M
W
E
V
M
S
F
G
E
R
P
Y
W
D
M
S
-
N
Q
D
V
I
N
A
I
E
Q
D
Y
R
L
P
P
P
P
D
C
P
T
S
L
H
Q
L
M
L
D
C
W
Q
K
D
R
N
A
R
P
R
F
P
Q
V
V
S
A
L
D
K
M
I
R
N
P
A
S
L
K
I
V
A
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
117
PsiBlast_CBE
54.33
41%
-109
- C2 -
2VWY
1
A:
[12-281]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
D
V
S
Y
V
K
I
E
E
V
I
G
A
G
E
F
G
E
V
C
R
G
R
L
--
K
A
P
G
K
K
E
S
C
V
A
I
K
T
L
K
-
G
G
Y
T
E
R
Q
R
R
E
F
L
S
E
A
S
I
M
G
Q
F
E
H
P
N
I
I
R
L
E
G
V
V
T
-
N
-
S
M
P
V
M
I
L
T
E
F
M
E
N
G
A
L
D
S
F
L
-
R
-
L
N
D
-
G
Q
F
T
V
I
Q
L
V
G
M
L
R
G
I
A
S
G
M
R
Y
L
A
E
M
S
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
S
R
F
L
E
ENSS
D
-------
G
G
K
I
P
I
R
W
T
A
P
E
A
I
A
F
R
K
F
T
S
A
S
D
A
W
S
Y
G
I
V
M
W
E
V
M
S
F
G
E
R
P
Y
W
D
M
S
-
N
Q
D
V
I
N
A
I
E
Q
D
Y
R
L
P
P
P
P
D
C
P
T
S
L
H
Q
L
M
L
D
C
W
Q
K
D
R
N
A
R
P
R
F
P
Q
V
V
S
A
L
D
K
M
I
R
N
P
A
S
L
K
I
V
A
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
118
PsiBlast_CBE
54.24
41%
-110
- C2 -
2VWX
1
A:
[12-281]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
D
V
S
Y
V
K
I
E
E
V
I
G
A
G
E
F
G
E
V
C
R
G
R
L
--
K
A
P
G
K
K
E
S
C
V
A
I
K
T
L
K
-
G
G
Y
T
E
R
Q
R
R
E
F
L
S
E
A
S
I
M
G
Q
F
E
H
P
N
I
I
R
L
E
G
V
V
T
-
N
-
S
M
P
V
M
I
L
T
E
F
M
E
N
G
A
L
D
S
F
L
-
R
-
L
N
D
-
G
Q
F
T
V
I
Q
L
V
G
M
L
R
G
I
A
S
G
M
R
Y
L
A
E
M
S
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
S
R
F
L
E
ENSS
D
-------
G
G
K
I
P
I
R
W
T
A
P
E
A
I
A
F
R
K
F
T
S
A
S
D
A
W
S
Y
G
I
V
M
W
E
V
M
S
F
G
E
R
P
Y
W
D
M
S
-
N
Q
D
V
I
N
A
I
E
Q
D
Y
R
L
P
P
P
P
D
C
P
T
S
L
H
Q
L
M
L
D
C
W
Q
K
D
R
N
A
R
P
R
F
P
Q
V
V
S
A
L
D
K
M
I
R
N
P
A
S
L
K
I
V
A
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
79
PsiBlast_CBE
54.23
42%
-115
- C2 -
2YN8
1
B:
[15-284]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
D
V
S
Y
V
K
I
E
E
V
I
G
A
G
E
F
G
E
V
C
R
G
R
L
--
K
A
P
G
K
K
E
S
C
V
A
I
K
T
L
K
-
G
G
Y
T
E
R
Q
R
R
E
F
L
S
E
A
S
I
M
G
Q
F
E
H
P
N
I
I
R
L
E
G
V
V
T
-
N
-
S
M
P
V
M
I
L
T
E
F
M
E
N
G
A
L
D
S
F
L
-
R
-
L
N
D
-
G
Q
F
T
V
I
Q
L
V
G
M
L
R
G
I
A
S
G
M
R
Y
L
A
E
M
S
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
-----------------------
P
I
R
W
T
A
P
E
A
I
A
F
R
K
F
T
S
A
S
D
V
W
S
Y
G
I
V
M
W
E
V
M
S
F
G
E
R
P
Y
W
D
M
S
-
N
Q
D
V
I
N
A
I
E
Q
D
Y
R
L
P
P
P
P
D
C
P
T
S
L
H
Q
L
M
L
D
C
W
Q
K
D
R
N
A
R
P
R
F
P
Q
I
V
S
A
L
D
K
M
I
R
N
P
A
S
L
K
I
V
A
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
59
PsiBlast_CBE
54.11
60%
-108
- C2 -
3FZR
1
A:
[4-272]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
I
A
R
E
D
V
V
L
N
R
I
L
G
E
G
F
F
G
E
V
Y
E
G
V
Y
--
T
N
H
K
G
E
K
I
N
V
A
V
K
T
C
K
K
D
C
T
L
D
N
-
K
E
K
F
M
S
E
A
V
I
M
K
N
L
D
H
P
H
I
V
K
L
I
G
I
I
E
-
E
-
E
-
P
T
W
I
I
M
E
L
Y
P
Y
G
E
L
G
H
Y
L
-
E
-
R
N
K
-
N
S
L
K
V
L
T
L
V
L
Y
S
L
Q
I
C
K
A
M
A
Y
L
E
S
I
N
C
V
H
R
D
I
A
V
R
N
I
L
V
A
S
P
E
C
V
K
L
G
D
F
G
L
S
R
----------------
T
R
L
P
I
K
W
M
S
P
E
S
I
N
F
R
R
F
T
T
A
S
D
V
W
M
F
A
V
C
M
W
E
I
L
S
F
G
K
Q
P
F
F
W
L
E
-
N
K
D
V
I
G
V
L
E
K
G
D
R
L
P
K
P
D
L
C
P
P
V
L
Y
T
L
M
T
R
C
W
D
Y
D
P
S
D
R
P
R
F
T
E
L
V
C
S
L
S
D
V
Y
Q
M
E
K
D
I
A
M
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
80
PsiBlast_CBE
53.91
42%
-118
- C2 -
2YN8
1
EPHB4_HUMAN
A:
[15-284]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
D
V
S
Y
V
K
I
E
E
V
I
G
A
G
E
F
G
E
V
C
R
G
R
L
--
K
-----
E
S
C
V
A
I
K
T
L
K
-
G
G
Y
T
E
R
Q
R
R
E
F
L
S
E
A
S
I
M
G
Q
F
E
H
P
N
I
I
R
L
E
G
V
V
T
-
N
-
S
M
P
V
M
I
L
T
E
F
M
E
N
G
A
L
D
S
F
L
-
R
-
L
N
D
-
G
Q
F
T
V
I
Q
L
V
G
M
L
R
G
I
A
S
G
M
R
Y
L
A
E
M
S
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
-----------------------
P
I
R
W
T
A
P
E
A
I
A
F
R
K
F
T
S
A
S
D
V
W
S
Y
G
I
V
M
W
E
V
M
S
F
G
E
R
P
Y
W
D
M
S
-
N
Q
D
V
I
N
A
I
E
Q
D
Y
R
L
P
P
P
P
D
C
P
T
S
L
H
Q
L
M
L
D
C
W
Q
K
D
R
N
A
R
P
R
F
P
Q
I
V
S
A
L
D
K
M
I
R
N
P
A
S
L
K
I
V
A
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
113
PsiBlast_CBE
53.64
41%
-110
- C2 -
2X9F
1
A:
[12-281]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
D
V
S
Y
V
K
I
E
E
V
I
G
A
G
E
F
G
E
V
C
R
G
R
L
--
K
A
P
G
K
K
E
S
C
V
A
I
K
T
L
----
Y
T
E
R
Q
R
R
E
F
L
S
E
A
S
I
M
G
Q
F
E
H
P
N
I
I
R
L
E
G
V
V
T
-
N
-
S
M
P
V
M
I
L
T
E
F
M
E
N
G
A
L
D
S
F
L
-
R
-
L
N
D
-
G
Q
F
T
V
I
Q
L
V
G
M
L
R
G
I
A
S
G
M
R
Y
L
A
E
M
S
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
S
R
F
L
-------------
G
G
K
I
P
I
R
W
T
A
P
E
A
I
A
F
R
K
F
T
S
A
S
D
A
W
S
Y
G
I
V
M
W
E
V
M
S
F
G
E
R
P
Y
W
D
M
S
-
N
Q
D
V
I
N
A
I
E
Q
D
Y
R
L
P
P
P
P
D
C
P
T
S
L
H
Q
L
M
L
D
C
W
Q
K
D
R
N
A
R
P
R
F
P
Q
V
V
S
A
L
D
K
M
I
R
N
P
A
S
L
K
I
V
A
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
94
PsiBlast_CBE
53.28
42%
-115
- C2 -
1JPA
1
B:
[29-298]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
D
I
S
C
V
K
I
E
Q
V
I
G
A
G
E
F
G
E
V
C
S
G
H
L
--
K
----
R
E
I
F
V
A
I
K
T
L
K
-
S
G
Y
T
E
K
Q
R
R
D
F
L
S
E
A
S
I
M
G
Q
F
D
H
P
N
V
I
H
L
E
G
V
V
T
-
K
-
S
-
P
V
M
I
I
T
E
F
M
E
N
G
S
L
D
S
F
L
-
R
-
Q
N
D
-
G
Q
F
T
V
I
Q
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
D
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
-----------------------
P
I
R
W
T
A
P
E
A
I
Q
Y
R
K
F
T
S
A
S
D
V
W
S
Y
G
I
V
M
W
E
V
M
S
Y
G
E
R
P
Y
W
D
M
T
-
N
-
D
V
I
N
A
I
E
Q
D
Y
R
L
P
P
P
M
D
C
P
S
A
L
H
Q
L
M
L
D
C
W
Q
K
D
R
N
H
R
P
K
F
G
Q
I
V
N
T
L
D
K
M
I
R
N
P
N
S
L
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
78
PsiBlast_CBE
52.90
42%
-113
- C2 -
4AW5
1
A:
[10-279]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
D
V
S
Y
V
K
I
E
E
V
I
G
A
G
E
F
G
E
V
C
R
G
R
L
--
K
A
P
G
K
K
E
S
C
V
A
I
K
T
L
K
-
G
G
Y
T
E
R
Q
R
R
E
F
L
S
E
A
S
I
M
G
Q
F
E
H
P
N
I
I
R
L
E
G
V
V
T
-
N
-
S
M
P
V
M
I
L
T
E
F
M
E
N
G
A
L
D
S
F
L
-
R
-
L
N
D
-
G
Q
F
T
V
I
Q
L
V
G
M
L
R
G
I
A
S
G
M
R
Y
L
A
E
M
S
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
---------------------
I
P
I
R
W
T
A
P
E
A
I
A
F
R
K
F
T
S
A
S
D
A
W
S
Y
G
I
V
M
W
E
V
M
S
F
G
E
R
P
Y
W
D
M
S
-
N
Q
D
V
I
N
A
I
E
Q
D
Y
R
L
P
P
P
P
D
C
P
T
S
L
H
Q
L
M
L
D
C
W
Q
K
D
R
N
A
R
P
R
F
P
Q
V
V
S
A
L
D
K
M
I
R
N
P
A
S
L
K
I
V
A
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
116
PsiBlast_CBE
52.66
41%
-107
- C2 -
2VWZ
1
A:
[12-281]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
D
V
S
Y
V
K
I
E
E
V
I
G
A
G
E
F
G
E
V
C
R
G
R
L
--
K
A
P
G
K
K
E
S
C
V
A
I
K
T
L
K
-
G
G
Y
T
E
R
Q
R
R
E
F
L
S
E
A
S
I
M
G
Q
F
E
H
P
N
I
I
R
L
E
G
V
V
T
-
N
-
S
M
P
V
M
I
L
T
E
F
M
E
N
G
A
L
D
S
F
L
-
R
-
L
N
D
-
G
Q
F
T
V
I
Q
L
V
G
M
L
R
G
I
A
S
G
M
R
Y
L
A
E
M
S
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
S
R
F
L
E
ENSS
D
-------
G
G
K
I
P
I
R
W
T
A
P
E
A
I
A
F
R
K
F
T
S
A
S
D
A
W
S
Y
G
I
V
M
W
E
V
M
S
F
G
E
R
P
Y
W
D
M
S
-
N
Q
D
V
I
N
A
I
E
Q
D
Y
R
L
P
P
P
P
D
C
P
T
S
L
H
Q
L
M
L
D
C
W
Q
K
D
R
N
A
R
P
R
F
P
Q
V
V
S
A
L
D
K
M
I
R
N
P
A
S
L
K
I
V
A
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
98
PsiBlast_CBE
51.91
40%
-101
- C2 -
2G1T
1
ABL1_HUMAN
D:
[5-277]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
N
Y
D
K
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
-----
K
K
Y
S
L
T
V
A
V
K
T
L
K
-
E
D
T
M
E
V
--
E
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
-
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
-
C
N
R
-
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
----
G
D
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
99
PsiBlast_CBE
51.21
40%
-99
- C2 -
2G1T
1
ABL1_HUMAN
C:
[7-280]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
D
K
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
-----
K
K
Y
S
L
T
V
A
V
K
T
L
K
-
E
D
T
M
E
V
--
E
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
-
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
-
C
N
R
-
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
----
G
D
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
S
D
E
V
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
92
PsiBlast_CBE
50.87
40%
-101
- C2 -
3IK3
1
ABL1_MOUSE
A:
[3-278]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
N
Y
D
K
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
-----
K
K
Y
S
L
T
V
A
V
K
T
L
K
-
E
D
T
M
E
V
--
E
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
-
P
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
-
C
N
R
-
Q
E
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
----------
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
S
D
E
V
E
K
E
L
G
K
R
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
85
PsiBlast_CBE
50.78
40%
-109
- C2 -
3PYY
3
ABL1_HUMAN
B:
[19-291]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
-----
K
K
Y
S
L
T
V
A
V
K
T
L
-------
V
--
E
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
-
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
-
C
N
R
-
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
-------------------
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
S
D
E
V
E
K
E
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
123
Fugue
50.61
39%
-109
* C2 *
1BYG
1
CSK_HUMAN
A:
[15-276]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
W
A
L
N
M
K
E
L
K
L
L
Q
T
I
G
K
G
E
F
G
D
V
M
L
G
D
Y
RG-------
N
K
V
A
V
K
C
I
K
------
N
D
A
Q
A
F
L
A
E
A
S
V
M
T
Q
L
R
H
S
N
L
V
Q
L
L
G
V
I
V
--E
E
-
G
L
Y
I
V
T
E
Y
M
A
K
G
S
L
V
D
Y
L
-
R
-
S
R
G
R
S
V
L
G
G
D
C
L
L
K
F
S
L
D
V
C
E
A
M
E
Y
L
E
G
N
N
F
V
H
R
D
L
A
A
R
N
V
L
V
S
E
D
N
V
A
K
V
S
D
F
G
--------------------
L
L
P
V
K
W
T
A
P
E
A
L
R
E
K
K
F
S
T
K
S
D
V
W
S
F
G
I
L
L
W
E
I
Y
S
F
G
R
V
P
Y
P
R
I
P
L-
K
D
V
V
P
R
V
E
K
G
Y
K
M
D
A
P
D
G
C
P
P
A
V
Y
E
V
M
K
N
C
W
H
L
D
A
A
M
R
P
S
F
L
Q
L
R
E
Q
L
E
H
I
K
T
H
E
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
61
PsiBlast_CBE
50.57
60%
-105
- C2 -
3ET7
1
A:
[4-272]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
I
A
R
E
D
V
V
L
N
R
I
L
G
E
G
F
F
G
E
V
Y
E
G
V
Y
--
T
N
H
K
G
E
K
I
N
V
A
V
K
T
C
K
K
D
C
T
L
D
N
-
K
E
K
F
M
S
E
A
V
I
M
K
N
L
D
H
P
H
I
V
K
L
I
G
I
I
E
-
E
-
E
-
P
T
W
I
I
M
E
L
Y
P
Y
G
E
L
G
H
Y
L
-
E
-
R
N
K
-
N
S
L
K
V
L
T
L
V
L
Y
S
L
Q
I
C
K
A
M
A
Y
L
E
S
I
N
C
V
H
R
D
I
A
V
R
N
I
L
V
A
S
P
E
C
V
K
L
G
D
F
G
L
S
R
----------------
T
R
L
P
I
K
W
M
S
P
E
S
I
N
F
R
R
F
T
T
A
S
D
V
W
M
F
A
V
C
M
W
E
I
L
S
F
G
K
Q
P
F
F
W
L
E
-
N
K
D
V
I
G
V
L
E
K
G
D
R
L
P
K
P
D
L
C
P
P
V
L
Y
T
L
M
T
R
C
W
D
Y
D
P
S
D
R
P
R
F
T
E
L
V
C
S
L
S
D
V
Y
Q
M
E
K
D
I
A
M
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
86
PsiBlast_CBE
50.30
40%
-109
- C2 -
3PYY
1
ABL1_HUMAN
A:
[18-286]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
D
K
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
-----
K
K
Y
S
L
T
V
A
V
K
T
L
K
-
E
----
V
--
E
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
-
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
-
C
N
R
-
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
----
G
D
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
100
PsiBlast_CBE
50.29
40%
-101
- C2 -
2G1T
1
ABL1_HUMAN
B:
[5-277]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
N
Y
D
K
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
-----
K
K
Y
S
L
T
V
A
V
K
T
L
K
-
E
D
T
M
E
V
--
E
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
-
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
-
C
N
R
-
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
----
G
D
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
109
PsiBlast_CBE
50.11
40%
-108
- C2 -
2HIW
1
ABL1_HUMAN
A:
[5-274]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
N
Y
D
K
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
-----
K
K
Y
S
L
T
V
A
V
K
T
L
K
-
E
D
T
M
E
V
--
E
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
-
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
-
C
N
R
-
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
----
G
D
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
88
PsiBlast_CBE
49.97
40%
-97
- C2 -
3OY3
1
ABL1_MOUSE
A:
[3-278]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
N
Y
D
K
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
-----
K
K
Y
S
L
T
V
A
V
K
T
L
K
-
E
D
T
M
E
V
--
E
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
-
P
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
-
C
N
R
-
Q
E
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
----
G
D
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
S
D
E
V
E
K
E
L
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
101
PsiBlast_CBE
49.95
40%
-104
- C2 -
2G1T
1
ABL1_HUMAN
A:
[7-277]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
D
K
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
-----
K
K
Y
S
L
T
V
A
V
K
T
L
K
-
E
D
T
M
E
V
--
E
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
-
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
-
C
N
R
-
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
----
G
D
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
107
PsiBlast_CBE
49.92
40%
-99
- C2 -
2G2F
1
ABL1_HUMAN
A:
[7-280]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
D
K
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
-----
K
K
Y
S
L
T
V
A
V
K
T
L
K
-
E
D
T
M
E
V
--
E
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
-
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
-
C
N
R
-
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
----
G
D
T
Y
T
A
P
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
S
D
E
V
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
89
PsiBlast_CBE
49.92
40%
-102
- C2 -
4WA9
1
ABL1_HUMAN
B:
[7-279]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
-----
K
K
Y
S
L
T
V
A
V
K
T
L
K
-
E
D
T
M
E
V
--
E
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
-
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
-
C
N
R
-
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
----
G
D
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
S
D
E
V
E
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
91
PsiBlast_CBE
49.72
40%
-98
- C2 -
3IK3
1
ABL1_MOUSE
B:
[3-278]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
N
Y
D
K
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
-----
K
K
Y
S
L
T
V
A
V
K
T
L
K
-
E
D
T
M
E
V
--
E
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
-
P
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
-
C
N
R
-
Q
E
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
----
G
D
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
S
D
E
V
E
K
E
L
G
K
R
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
104
PsiBlast_CBE
49.49
40%
-100
- C2 -
2G2H
1
ABL1_HUMAN
B:
[8-279]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
-----
K
K
Y
S
L
T
V
A
V
K
T
L
K
-
E
D
T
M
E
V
--
E
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
-
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
-
C
N
R
-
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
----
G
D
T
Y
T
A
P
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
S
D
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
96
PsiBlast_CBE
49.29
40%
-101
- C2 -
3UE4
1
ABL1_HUMAN
B:
[8-277]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
--
G
E
V
Y
E
G
V
W
-----
K
K
Y
S
L
T
V
A
V
K
T
L
K
-
E
D
T
M
E
V
--
E
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
-
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
-
C
N
R
-
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
----
G
D
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
108
PsiBlast_CBE
49.20
40%
-107
- C2 -
2HIW
1
ABL1_HUMAN
B:
[5-274]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
N
Y
D
K
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
-----
K
K
Y
S
L
T
V
A
V
K
T
L
K
-
E
D
T
M
E
V
--
E
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
-
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
-
C
N
R
-
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
----
G
D
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
111
PsiBlast_CBE
49.13
40%
-101
- C2 -
3QRJ
1
ABL1_HUMAN
B:
[11-275]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
-----
K
K
Y
S
L
T
V
A
V
K
T
L
K
-
E
D
T
M
E
V
--
E
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
-
P
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
-
C
N
R
-
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
----
G
D
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
93
PsiBlast_CBE
48.81
40%
-100
- C2 -
2Z60
1
ABL1_MOUSE
A:
[3-278]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
N
Y
D
K
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
-----
K
K
Y
S
L
T
V
A
V
K
T
L
K
-
E
---
E
V
--
E
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
-
P
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
-
C
N
R
-
Q
E
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
----
G
D
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
S
D
E
V
E
K
E
L
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
105
PsiBlast_CBE
48.70
40%
-96
- C2 -
2G2H
1
ABL1_HUMAN
A:
[8-279]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
-----
K
K
Y
S
L
T
V
A
V
K
T
L
K
-
E
D
T
M
E
V
--
E
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
-
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
-
C
N
R
-
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
----
G
D
T
Y
T
A
P
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
S
D
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
87
PsiBlast_CBE
48.58
40%
-99
- C2 -
3OY3
1
ABL1_MOUSE
B:
[3-278]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
N
Y
D
K
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
-----
K
K
Y
S
L
T
V
A
V
K
T
L
K
-
E
D
T
M
E
V
--
E
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
-
P
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
-
C
N
R
-
Q
E
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
----
G
D
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
S
D
E
V
E
K
E
L
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
119
PsiBlast_CBE
48.56
40%
-105
- C2 -
3MS9
2
ABL1_MOUSE
B:
[8-276]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
N
Y
D
K
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
-----
K
K
Y
S
L
T
V
A
V
K
T
L
----
T
M
E
V
--
E
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
-
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
-
C
N
R
-
Q
E
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
----
G
D
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
121
PsiBlast_CBE
48.49
40%
-101
- C2 -
3K5V
2
ABL1_MOUSE
B:
[8-283]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
N
Y
D
K
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
-----
K
K
Y
S
L
T
V
A
V
K
T
L
K
----
M
E
V
--
E
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
-
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
-
C
N
R
-
Q
E
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
----
G
D
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
S
D
E
V
E
K
E
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
83
PsiBlast_CBE
48.22
42%
-107
- C2 -
4CSV
1
?
A:
[6-268]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
I
P
R
S
E
I
T
L
E
R
K
L
G
S
G
Q
F
G
E
V
Y
E
G
K
W
-----
R
N
Y
N
I
E
V
A
V
K
T
L
K
-
E
G
T
M
S
V
--
E
E
F
L
Q
E
A
Q
I
M
K
K
L
K
H
P
N
L
V
Q
L
Y
G
V
C
T
K
E
-
P
-
P
I
Y
I
I
T
E
Y
M
S
H
G
S
L
L
D
Y
L
-
R
D
C
-----
V
N
A
Q
A
L
L
D
M
A
A
Q
V
A
S
G
M
A
Y
L
E
S
Q
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
N
V
V
K
V
A
D
F
G
---------------------
F
P
I
K
W
T
A
P
E
A
I
S
Y
N
R
F
S
I
K
S
D
V
W
A
F
G
I
L
L
W
E
I
F
T
Y
G
Q
V
P
Y
P
G
M
S
-
G
S
E
V
I
E
Q
V
E
R
G
Y
R
M
P
R
P
Q
G
C
P
E
E
I
Y
E
L
M
L
Q
C
W
N
K
S
P
E
E
R
P
T
F
A
E
T
L
H
A
L
E
T
M
F
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
97
PsiBlast_CBE
48.12
40%
-98
- C2 -
3UE4
1
ABL1_HUMAN
A:
[8-277]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
-----
K
K
Y
S
L
T
V
A
V
K
T
L
K
-
E
D
T
M
E
V
--
E
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
-
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
-
C
N
R
-
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
----
G
D
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
110
PsiBlast_CBE
48.03
40%
-98
- C2 -
2F4J
1
ABL1_HUMAN
A:
[4-279]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
N
Y
D
K
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
-----
K
K
Y
S
L
T
V
A
V
K
T
L
K
-
E
D
T
M
E
V
--
E
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
-
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
-
C
N
R
-
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
----
G
D
T
Y
T
A
P
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
S
D
E
V
E
K
E
L
G
K
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
120
PsiBlast_CBE
47.96
40%
-104
- C2 -
3MS9
2
ABL1_MOUSE
A:
[8-276]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
N
Y
D
K
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
-----
K
K
Y
S
L
T
V
A
V
K
T
L
-------
V
--
E
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
-
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
-
C
N
R
-
Q
E
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
------
G
D
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
106
PsiBlast_CBE
47.71
40%
-102
- C2 -
2G2F
1
ABL1_HUMAN
B:
[9-277]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
-----
E
V
Y
E
G
V
W
-----
K
K
Y
S
L
T
V
A
V
K
T
L
K
-
E
D
T
M
E
V
--
E
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
-
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
-
C
N
R
-
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
----
G
D
T
Y
T
A
P
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
81
PsiBlast_CBE
47.26
40%
-98
- C2 -
4XEY
1
ABL1_HUMAN
A:
[116-388]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
Y
D
K
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
----
E
V
Y
E
G
V
W
-----
K
K
Y
S
L
T
V
A
V
K
T
L
K
-
E
D
T
M
E
V
--
E
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
-
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
-
C
N
R
-
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
----
G
D
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
103
PsiBlast_CBE
47.19
40%
-95
- C2 -
2G2I
1
ABL1_HUMAN
A:
[5-277]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
N
Y
D
K
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
---
E
V
Y
E
G
V
W
-----
K
K
Y
S
L
T
V
A
V
K
T
L
K
-
E
D
T
M
E
V
--
E
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
-
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
-
C
N
R
-
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
----
G
D
T
Y
T
A
P
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
102
PsiBlast_CBE
46.50
40%
-101
- C2 -
2G2I
1
ABL1_HUMAN
B:
[7-275]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
D
K
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
----
E
V
Y
E
G
V
W
-----
K
K
Y
S
L
T
V
A
V
K
T
L
K
-
E
D
T
M
E
V
--
E
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
-
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
-
C
N
R
-
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
----
G
D
T
Y
T
A
P
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
82
PsiBlast_CBE
45.93
42%
-102
- C2 -
4UEU
1
?
A:
[6-268]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
I
P
R
S
E
I
T
L
E
R
K
L
G
S
G
Q
F
G
E
V
Y
E
G
K
W
-----
R
N
Y
N
I
E
V
A
V
K
T
L
K
-
E
G
T
M
S
V
--
E
E
F
L
Q
E
A
Q
I
M
K
K
L
K
H
P
N
L
V
Q
L
Y
G
V
C
T
K
E
-
P
-
P
I
Y
I
I
T
E
Y
M
S
H
G
S
L
L
D
Y
L
-
R
D
C
E
G
-
H
T
V
N
A
Q
A
L
L
D
M
A
A
Q
V
A
S
G
M
A
Y
L
E
S
Q
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
N
V
V
K
V
A
D
F
G
L
A
R
L
I
--------------
A
K
F
P
I
K
W
T
A
P
E
A
I
S
Y
N
R
F
S
I
K
S
D
V
W
A
F
G
I
L
L
W
E
I
F
T
Y
G
Q
V
P
Y
P
G
M
S
-
G
S
E
V
I
E
Q
V
E
R
G
Y
R
M
P
R
P
Q
G
C
P
E
E
I
Y
E
L
M
L
Q
C
W
N
K
S
P
E
E
R
P
T
F
A
E
T
L
H
A
L
E
T
M
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
90
PsiBlast_CBE
45.85
40%
-97
- C2 -
4WA9
1
ABL1_HUMAN
A:
[10-278]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
-----
K
K
Y
S
L
T
V
A
V
K
-----------------------
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
----
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
-
C
N
R
-
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
----
G
D
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
S
D
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------