@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : FGFR1_HUMAN: (2015-10-08 )
MWSWKCLLFWAVLVTATLCTARPSPTLPEQAQPWGAPVEVESFLVHPGDLLQLRCRLRDDVQSINWLRDGVQLAESNRTRITGEEVEVQDSVPADSGLYACVTSSPSGSDTTYFSVNVSDALPSSEDDDDDDDSSSEEKETDNTKPNRMPVAPYWTSPEKMEKKLHAVPAAKTVKFKCPSSGTPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDKGNYTCIVENEYGSINHTYQLDVVERSPHRPILQAGLPANKTVALGSNVEFMCKVYSDPQPHIQWLKHIEVNGSKIGPDNLPYVQILKTAGVNTTDKEMEVLHLRNVSFEDAGEYTCLAGNSIGLSHHSAWLTVLEALEERPAVMTSPLYLEIIIYCTGAFLISCMVGSVIVYKMKSGTKKSDFHSQMAVHKLAKSIPLRRQVTVSADSSASMNSGVLLVRPSRLSSSGTPMLAGVSEYELPEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIVALTSNQEYLDLSMPLDQYSPSFPDTRSSTCSSGEDSVFSHEPLPEEPCLPRHPAQLANGGLKRR
Atome Classification :
(62 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770.......780.......790.......800.......810.......820
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MW
S
W
K
C
L
L
F
W
A
V
L
V
T
A
T
L
CTARPSPTLPEQAQPWGAP
V
E
V
E
S
FLVHP
G
D
L
L
Q
L
R
C
R
L
R
D
D
V
Q
S
I
N
W
L
R
D
G
V
Q
L
AESNRTRITG
E
E
V
E
V
QDSVPADS
G
L
Y
A
C
VTSSPSGSD
T
T
Y
F
S
V
NVSDALPSSEDDDDDDDSSSEEKETDNTKPNRMPVAPYWT
S
P
E
K
M
E
K
K
L
HAVPAA
K
T
V
K
F
KCPSSGTPN
P
T
L
R
W
L
KNGKEFKPDHRIG
G
Y
K
V
R
Y
A
T
W
S
I
I
M
D
SVVPSDKG
N
Y
T
C
I
V
ENEYGSI
N
H
T
Y
Q
L
D
V
VERSPHR
P
I
L
QAGLPAN
K
T
V
ALGSN
V
E
F
M
C
K
VYSDP
Q
P
H
I
Q
W
L
K
H
IEVNGSKIGPDNL
P
Y
V
Q
I
L
K
TAGVNTTDK
E
M
E
V
L
H
L
RNVSFEDAG
E
Y
T
C
LAGNSIGL
S
H
H
S
A
W
L
T
V
L
E
A
L
E
ERPAVMTS
P
L
Y
L
E
I
I
I
YC
T
G
A
F
L
I
S
C
M
V
G
S
V
I
V
Y
K
MKSGTKK
S
D
F
H
S
Q
M
A
V
H
K
L
A
K
SIPL
R
R
Q
V
T
VSADSSASMNS
G
V
L
L
V
RPSRLSSSGT
P
M
L
AGVSEYELPEDPRWELPRD
R
L
V
LGKPLGEGC
F
G
Q
V
V
L
A
E
AIGLDKDKP
N
R
V
T
K
V
A
V
K
M
L
KSDA
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
GK
H
K
N
I
I
N
L
L
G
A
CTQDG
P
L
Y
V
I
V
E
YASKG
N
L
R
E
Y
L
Q
ARRPPGLEYCYNPSH
N
P
E
E
QL
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
AAR
N
V
L
VTED
N
V
M
K
I
A
D
FGL
A
R
D
I
H
H
I
D
Y
Y
K
KTTNGRL
P
V
K
WM
A
P
E
A
L
F
D
R
I
Y
THQ
S
D
V
W
S
F
G
V
L
L
W
E
I
F
TLGGSPYPGV
P
V
E
E
L
F
K
L
L
KEGHRMDKPSN
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
AVPSQR
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
A
LTSNQ
E
Y
L
DLSM
P
L
D
QYSPSFPDTRSSTCSSGEDSVFSHEPLPEEPCLPRH
P
A
Q
L
ANGGLKRR
56
PsiBlast_CBE
95.56
98%
-119
- C4 -
4RWK
1
B:
[11-315]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
V
S
E
Y
E
L
P
E
D
P
R
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
D
K
D
K
P
N
R
V
T
K
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
M
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
----------------
Q
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
N
V
M
K
I
A
D
F
G
L
A
-----
I
D
Y
Y
K
K
T
--
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
V
P
V
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
A
L
T
S
N
-----------------------------------------------------------
54
PsiBlast_CBE
95.37
98%
-130
- C4 -
4WUN
1
B:
[7-308]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
E
Y
E
L
P
E
D
P
R
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
---
K
P
N
R
V
T
K
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
P
P
--------------
Q
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
N
V
M
K
I
A
D
F
G
L
-----------------
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
V
P
V
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
A
L
T
S
------------------------------------------------------------
48
PsiBlast_CBE
95.26
99%
-121
- C4 -
4NKA
3
FGFR1_HUMAN
A:
[8-309]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
E
D
P
R
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
----
Q
V
V
L
A
E
A
I
G
L
D
K
D
K
P
N
R
V
T
K
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
P
P
------------
E
E
Q
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
N
V
M
K
I
A
D
F
G
-------
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
V
P
V
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
A
L
T
S
N
Q
E
---------------------------------------------------------
36
PsiBlast_CBE
95.15
99%
-120
- C4 -
4V05
4
FGFR1_HUMAN
A:
[8-309]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
E
D
P
R
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
D
K
D
K
P
N
R
V
T
K
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
P
P
G
-----------
E
E
Q
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
N
V
M
K
I
A
D
F
G
L
A
R
----
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
V
P
V
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
A
L
T
S
N
Q
E
---------------------------------------------------------
40
PsiBlast_CBE
94.96
99%
-123
- C4 -
4V01
7
FGFR1_HUMAN
A:
[9-309]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
E
D
P
R
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
----
G
Q
V
V
L
A
E
A
I
G
L
D
K
--
P
N
R
V
T
K
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
P
P
--------------
Q
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
N
V
M
K
I
A
D
F
--------
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
V
P
V
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
A
L
T
S
N
Q
E
---------------------------------------------------------
63
PsiBlast_CBE
94.81
99%
-122
- C4 -
3C4F
1
FGFR1_HUMAN
A:
[1-302]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
E
D
P
R
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
D
K
D
K
P
N
R
V
T
K
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
P
P
------------
E
E
Q
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
N
V
M
K
I
A
D
F
G
L
A
R
D
I
H
H
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
V
P
V
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
A
L
T
S
N
Q
E
---------------------------------------------------------
50
PsiBlast_CBE
94.69
99%
-123
- C4 -
4NK9
5
FGFR1_HUMAN
A:
[8-309]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
E
D
P
R
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
D
-
D
K
P
N
R
V
T
K
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
P
P
-------------
E
Q
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
N
V
M
K
I
A
D
F
G
-------
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
V
P
V
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
A
L
T
S
N
Q
E
---------------------------------------------------------
49
PsiBlast_CBE
94.21
99%
-121
- C4 -
4NK9
2
B:
[4-309]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
S
E
Y
E
L
P
E
D
P
R
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
D
K
--
P
N
R
V
T
K
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
P
P
--------------
Q
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
N
V
M
K
I
A
D
F
G
--------
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
V
P
V
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
A
L
T
S
N
Q
E
---------------------------------------------------------
44
PsiBlast_CBE
93.99
99%
-114
- C4 -
4UWB
4
?
A:
[8-309]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
E
D
P
R
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
D
K
D
K
P
N
R
V
T
K
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
P
P
G
L
E
Y
S
--
P
S
H
N
P
E
E
Q
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
N
V
M
K
I
A
D
F
G
L
A
R
D
-
H
H
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
V
P
V
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
A
L
T
S
N
Q
E
---------------------------------------------------------
20
PsiBlast_PDB
93.81
99%
-121
- C4 -
4F65
6
FGFR1_HUMAN
A:
[8-309]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
E
D
P
R
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
D
K
--
P
N
R
V
T
K
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
P
P
-----------
P
E
E
Q
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
N
V
M
K
I
A
D
F
----------
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
V
P
V
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
A
L
T
S
N
Q
E
---------------------------------------------------------
61
PsiBlast_CBE
93.80
99%
-121
- C4 -
3RHX
5
FGFR1_HUMAN
A:
[5-305]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
E
D
P
R
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
D
K
D
K
P
N
R
V
T
K
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
P
P
------------
E
E
Q
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
N
V
M
K
I
A
D
F
G
L
A
R
D
I
H
H
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
V
P
V
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
A
L
T
S
N
Q
----------------------------------------------------------
47
PsiBlast_CBE
93.68
99%
-120
- C4 -
4NKA
2
B:
[2-309]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
G
V
S
E
Y
E
L
P
E
D
P
R
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
D
K
--
P
N
R
V
T
K
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
P
P
-------------
E
Q
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
N
V
M
K
I
A
D
F
------
H
H
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
V
P
V
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
A
L
T
S
N
Q
E
---------------------------------------------------------
58
PsiBlast_CBE
93.48
99%
-116
- C4 -
5A4C
7
?
B:
[1-307]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
A
S
E
Y
E
L
P
E
D
P
R
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
D
---
P
N
R
V
T
K
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
P
P
-------------
E
Q
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
N
V
M
K
I
A
D
F
G
L
A
-----
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
V
P
V
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
A
L
T
S
N
Q
E
---------------------------------------------------------
46
PsiBlast_CBE
93.42
99%
-124
- C4 -
4NKS
1
FGFR1_HUMAN
A:
[9-306]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
E
D
P
R
W
E
L
P
R
D
R
L
V
L
G
K
P
L
-----
G
Q
V
V
L
A
E
A
I
-------
N
R
V
T
K
V
A
V
K
M
L
K
-
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
P
P
--------------
Q
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
N
V
M
K
I
A
D
F
G
L
------
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
V
P
V
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
A
L
T
S
------------------------------------------------------------
59
PsiBlast_CBE
93.31
99%
-116
- C4 -
5A4C
6
?
A:
[6-307]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
E
D
P
R
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
--
F
G
Q
V
V
L
A
E
A
I
G
L
D
K
D
K
P
N
R
V
T
K
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
P
P
G
L
E
Y
S
Y
N
P
S
H
N
P
E
E
Q
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
N
V
M
K
I
A
D
F
G
L
------
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
V
P
V
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
A
L
T
S
N
Q
E
---------------------------------------------------------
62
PsiBlast_CBE
93.13
99%
-119
- C4 -
3C4F
1
B:
[1-302]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
E
D
P
R
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
D
K
D
K
P
N
R
V
T
K
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
P
P
------------
E
E
Q
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
N
V
M
K
I
A
D
F
G
L
A
R
D
I
H
H
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
V
P
V
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
A
L
T
S
N
Q
E
---------------------------------------------------------
57
PsiBlast_CBE
92.96
98%
-112
- C4 -
4RWK
1
FGFR1_HUMAN
A:
[9-316]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
A
G
V
S
E
Y
E
L
P
E
D
P
R
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
D
K
D
K
P
N
R
V
T
K
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
M
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
P
P
G
L
E
Y
S
Y
N
P
S
H
N
P
E
E
Q
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
N
V
M
K
I
A
D
F
G
L
A
R
D
I
H
H
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
V
P
V
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
A
L
T
S
N
Q
----------------------------------------------------------
51
PsiBlast_CBE
92.74
99%
-121
- C4 -
4F65
4
B:
[4-307]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
S
E
Y
E
L
P
E
D
P
R
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
D
---
P
N
R
V
T
K
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
P
---------------
Q
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
N
V
M
K
I
A
D
F
-------
H
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
V
P
V
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
A
L
T
S
N
-----------------------------------------------------------
52
PsiBlast_CBE
92.70
99%
-123
- C4 -
4F64
3
B:
[5-305]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
E
Y
E
L
P
E
D
P
R
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
----
P
N
R
V
T
K
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
----------------
Q
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
N
V
M
K
I
A
D
F
G
L
A
------
D
Y
Y
K
K
---
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
V
P
V
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
A
L
T
-------------------------------------------------------------
53
PsiBlast_CBE
91.93
99%
-123
- C4 -
4F63
3
B:
[5-305]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
E
Y
E
L
P
E
D
P
R
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
G
A
-
G
Q
V
V
L
A
E
A
I
G
L
----
P
N
R
V
T
K
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
----------------
Q
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
N
V
M
K
I
A
D
F
G
L
A
------
D
Y
Y
K
K
---
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
V
P
V
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
A
L
T
-------------------------------------------------------------
45
PsiBlast_CBE
91.87
99%
-123
- C4 -
4NKS
1
B:
[5-305]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
E
Y
E
L
P
E
D
P
R
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
G
A
-
G
Q
V
V
L
A
E
A
I
G
L
----
P
N
R
V
T
K
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
----------------
Q
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
N
V
M
K
I
A
D
F
G
L
A
------
D
Y
Y
K
K
---
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
V
P
V
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
A
L
T
-------------------------------------------------------------
41
PsiBlast_CBE
91.51
99%
-116
- C4 -
4UWC
9
?
B:
[3-308]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
V
S
E
Y
E
L
P
E
D
P
R
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
D
K
--
P
N
R
V
T
K
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
P
P
G
L
E
Y
S
Y
---
H
N
P
E
E
Q
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
N
V
M
K
I
A
D
F
G
L
A
R
D
I
H
H
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
V
P
V
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
A
L
T
S
N
Q
----------------------------------------------------------
55
PsiBlast_CBE
91.14
98%
-119
- C4 -
4WUN
1
FGFR1_HUMAN
A:
[11-311]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
E
D
P
R
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
D
K
D
K
P
N
R
V
T
K
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
P
P
-
L
E
Y
S
Y
N
P
S
H
N
P
E
E
Q
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
N
V
M
K
I
A
D
F
G
------------------
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
V
P
V
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
A
L
T
S
N
Q
E
---------------------------------------------------------
60
PsiBlast_CBE
90.69
99%
-120
- C4 -
3RHX
3
B:
[2-302]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
E
Y
E
L
P
E
D
P
R
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
----
P
N
R
V
T
K
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
----------------
Q
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
N
V
M
K
I
A
D
F
G
L
A
------
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
V
P
V
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
A
L
T
-------------------------------------------------------------
43
PsiBlast_CBE
90.47
99%
-112
- C4 -
4UWB
3
?
B:
[3-309]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
V
S
E
Y
E
L
P
E
D
P
R
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
D
K
--
P
N
R
V
T
K
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
P
P
G
L
E
Y
S
Y
---
H
N
P
E
E
Q
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
N
V
M
K
I
A
D
F
G
L
A
R
---
H
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
V
P
V
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
A
L
T
S
N
Q
E
---------------------------------------------------------
71
PsiBlast_CBE
89.40
87%
-117
- C4 -
3B2T
1
B:
[1-307]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
M
L
A
G
V
S
E
Y
E
L
P
E
D
P
K
W
E
F
P
R
D
K
L
T
L
G
K
P
L
----
F
G
Q
V
V
M
A
E
A
V
G
I
D
--
K
P
K
E
A
V
T
V
A
V
K
M
L
K
D
D
A
T
E
K
D
L
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
A
R
R
P
P
--------------
Q
M
T
F
K
D
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
T
A
R
N
V
L
V
T
E
N
N
V
M
K
I
A
D
F
G
L
A
R
D
I
N
N
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
G
G
S
P
Y
P
G
I
P
V
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
L
T
L
T
-------------------------------------------------------------
101
PsiBlast_CBE
89.12
86%
-120
- C4 -
2PY3
1
FGFR2_HUMAN
A:
[24-322]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
E
D
P
K
W
E
F
P
R
D
K
L
T
L
G
K
P
L
----
F
G
Q
V
V
M
A
E
A
V
G
I
D
K
D
K
P
K
E
A
V
T
V
A
V
K
M
L
K
D
D
A
T
E
K
D
L
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
G
Y
A
S
K
G
N
L
R
E
Y
L
R
A
R
R
P
-------------
E
E
Q
M
T
F
K
D
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
N
N
V
M
K
I
A
D
F
G
L
A
R
D
I
N
N
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
G
G
S
P
Y
P
G
I
P
V
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
L
T
L
T
T
N
-----------------------------------------------------------
82
PsiBlast_CBE
89.12
86%
-121
- C4 -
2PZP
1
FGFR2_HUMAN
A:
[24-322]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
E
D
P
K
W
E
F
P
R
D
K
L
T
L
G
K
P
L
------
Q
V
V
M
A
E
A
V
G
I
D
K
D
K
P
K
E
A
V
T
V
A
V
K
M
L
K
D
D
A
T
E
E
D
L
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
A
R
R
P
-------------
E
E
Q
M
T
F
K
D
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
N
N
V
M
K
I
A
D
F
G
L
A
R
D
I
N
N
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
G
G
S
P
Y
P
G
I
P
V
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
L
T
L
T
T
N
-----------------------------------------------------------
83
PsiBlast_CBE
89.03
86%
-123
- C4 -
4J95
2
?
D:
[23-320]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
E
D
P
K
W
E
F
P
R
D
K
L
T
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
M
A
E
A
V
G
I
D
K
D
K
P
K
E
A
V
T
V
A
V
K
M
L
K
D
D
A
T
E
K
D
L
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
A
R
R
----------------
Q
M
T
F
K
D
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
N
N
V
M
K
I
A
D
F
G
L
A
R
D
I
-----------
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
G
G
S
P
Y
P
G
I
P
V
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
L
T
L
T
-------------------------------------------------------------
81
PsiBlast_CBE
88.85
86%
-119
- C4 -
2PZP
1
B:
[24-322]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
E
D
P
K
W
E
F
P
R
D
K
L
T
L
G
K
P
L
------
Q
V
V
M
A
E
A
V
G
I
D
K
D
K
P
K
E
A
V
T
V
A
V
K
M
L
K
D
D
A
T
E
E
D
L
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
A
R
R
P
P
G
-----------
E
E
Q
M
T
F
K
D
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
N
N
V
M
K
I
A
D
F
G
L
A
R
D
I
N
N
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
G
G
S
P
Y
P
G
I
P
V
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
L
T
L
T
T
N
-----------------------------------------------------------
86
PsiBlast_CBE
88.77
86%
-119
- C4 -
4J95
1
FGFR2_HUMAN
A:
[23-320]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
E
D
P
K
W
E
F
P
R
D
K
L
T
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
M
A
E
A
V
G
I
D
K
D
K
P
K
E
A
V
T
V
A
V
K
M
L
K
D
D
A
T
E
K
D
L
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
A
R
R
P
---------------
Q
M
T
F
K
D
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
N
N
V
M
K
I
A
D
F
G
L
A
R
D
I
----
Y
Y
K
N
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
G
G
S
P
Y
P
G
I
P
V
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
L
T
L
T
-------------------------------------------------------------
92
PsiBlast_CBE
88.75
86%
-119
- C4 -
4J99
1
?
D:
[21-320]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
Y
E
L
P
E
D
P
K
W
E
F
P
R
D
K
L
T
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
M
A
E
A
V
G
I
D
K
D
K
P
K
E
A
V
T
V
A
V
K
M
L
K
D
D
A
T
E
K
D
L
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
A
R
R
----------------
Q
M
T
F
K
D
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
N
N
V
M
K
I
A
D
F
G
L
A
R
D
I
N
N
I
D
Y
Y
K
T
---
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
G
G
S
P
Y
P
G
I
P
V
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
L
T
L
T
-------------------------------------------------------------
73
PsiBlast_CBE
88.42
86%
-121
- C4 -
2PZR
1
B:
[23-322]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
E
D
P
K
W
E
F
P
R
D
K
L
T
L
G
K
P
L
------
Q
V
V
M
A
E
A
V
G
I
D
K
D
K
P
K
E
A
V
T
V
A
V
K
M
L
K
D
D
A
T
E
K
D
L
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
A
R
R
P
P
------------
E
E
Q
M
T
F
K
D
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
N
N
V
M
R
I
A
D
F
G
L
A
R
D
I
N
N
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
G
G
S
P
Y
P
G
I
P
V
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
L
T
L
T
T
N
-----------------------------------------------------------
94
PsiBlast_CBE
88.34
86%
-117
- C4 -
4J99
1
B:
[23-320]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
E
D
P
K
W
E
F
P
R
D
K
L
T
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
M
A
E
A
V
G
I
D
K
D
K
P
K
E
A
V
T
V
A
V
K
M
L
K
D
D
A
T
E
K
D
L
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
A
R
R
P
P
G
M
E
Y
S
Y
D
-------
Q
M
T
F
K
D
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
N
N
V
M
K
I
A
D
F
G
L
A
R
D
I
N
N
I
D
Y
Y
K
T
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
G
G
S
P
Y
P
G
I
P
V
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
L
T
L
T
-------------------------------------------------------------
67
PsiBlast_CBE
88.24
87%
-120
- C4 -
3RI1
1
?
A:
[13-310]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
E
D
P
K
W
E
F
P
R
D
K
L
T
L
G
K
P
L
G
E
G
C
F
G
Q
V
V
M
A
E
A
V
G
I
D
K
D
K
P
K
E
A
V
T
V
A
V
K
M
L
K
D
D
A
T
E
K
D
L
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
A
R
R
P
P
-------------
E
Q
M
T
F
K
D
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
N
N
V
M
K
I
A
D
F
G
L
A
R
D
I
N
N
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
G
G
S
P
Y
P
G
I
P
V
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
L
T
L
T
T
------------------------------------------------------------
72
PsiBlast_CBE
88.13
87%
-114
- C4 -
3B2T
1
FGFR2_HUMAN
A:
[7-311]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
E
Y
E
L
P
E
D
P
K
W
E
F
P
R
D
K
L
T
L
G
K
P
L
G
E
G
C
F
G
Q
V
V
M
A
E
A
V
G
I
D
---
P
K
E
A
V
T
V
A
V
K
M
L
K
D
D
A
T
E
K
D
L
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
A
R
R
P
P
--------------
Q
M
T
F
K
D
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
T
A
R
N
V
L
V
T
E
N
N
V
M
K
I
A
D
F
G
L
A
R
D
I
N
N
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
G
G
S
P
Y
P
G
I
P
V
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
L
T
L
T
T
N
Q
E
---------------------------------------------------------
93
PsiBlast_CBE
88.07
86%
-120
- C4 -
4J99
1
?
C:
[23-320]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
E
D
P
K
W
E
F
P
R
D
K
L
T
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
M
A
E
A
V
G
I
D
K
D
K
P
K
E
A
V
T
V
A
V
K
M
L
K
D
D
A
T
E
K
D
L
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
A
R
R
P
P
G
M
E
Y
S
Y
D
-------
Q
M
T
F
K
D
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
N
N
V
M
K
I
A
D
F
G
L
A
R
D
I
N
N
I
D
Y
Y
K
T
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
G
G
S
P
Y
P
G
I
P
V
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
L
T
L
T
-------------------------------------------------------------
77
PsiBlast_CBE
87.96
86%
-118
- C4 -
4J97
1
?
D:
[22-320]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
E
L
P
E
D
P
K
W
E
F
P
R
D
K
L
T
L
G
K
P
L
-----
G
Q
V
V
M
A
E
A
V
G
I
D
K
D
K
P
K
E
A
V
T
V
A
V
K
M
L
K
D
D
A
T
E
K
D
L
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
A
R
R
P
P
---------
R
V
P
E
E
Q
M
T
F
K
D
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
N
N
V
M
K
I
A
D
F
G
L
A
R
D
I
N
N
I
D
Y
Y
K
E
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
G
G
S
P
Y
P
G
I
P
V
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
L
T
L
T
-------------------------------------------------------------
90
PsiBlast_CBE
87.92
86%
-121
- C4 -
2PZ5
1
B:
[24-322]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
E
D
P
K
W
E
F
P
R
D
K
L
T
L
G
K
P
L
------
Q
V
V
M
A
E
A
V
G
I
D
K
D
K
P
K
E
A
V
T
V
A
V
K
M
L
K
D
D
A
T
E
K
D
L
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
T
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
A
R
R
P
P
-------------
E
Q
M
T
F
K
D
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
N
N
V
M
K
I
A
D
F
G
L
A
R
D
I
N
N
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
G
G
S
P
Y
P
G
I
P
V
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
L
T
L
T
T
N
-----------------------------------------------------------
99
PsiBlast_CBE
87.80
86%
-114
- C4 -
2PWL
1
FGFR2_HUMAN
A:
[23-320]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
E
D
P
K
W
E
F
P
R
D
K
L
T
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
M
A
E
A
V
G
I
D
K
D
K
P
K
E
A
V
T
V
A
V
K
M
L
K
D
D
A
T
E
K
D
L
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
H
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
A
R
R
P
--------------
E
Q
M
T
F
K
D
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
N
N
V
M
K
I
A
D
F
G
L
A
R
D
I
N
N
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
G
G
S
P
Y
P
G
I
P
V
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
L
T
L
T
-------------------------------------------------------------
88
PsiBlast_CBE
87.69
86%
-123
- C4 -
2Q0B
1
FGFR2_HUMAN
A:
[24-321]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
E
D
P
K
W
E
F
P
R
D
K
L
T
L
G
K
P
L
-----
G
Q
V
V
M
A
E
A
V
G
I
D
K
D
K
P
K
E
A
V
T
V
A
V
K
M
L
K
D
D
A
T
E
K
D
L
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
A
Y
A
S
K
G
N
L
R
E
Y
L
R
A
R
R
P
-------------
E
E
Q
M
T
F
K
D
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
N
N
V
M
K
I
A
D
F
G
L
A
R
D
I
N
N
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
G
G
S
P
Y
P
G
I
P
V
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
L
T
L
T
T
------------------------------------------------------------
91
PsiBlast_CBE
87.67
86%
-120
- C4 -
2PZ5
1
FGFR2_HUMAN
A:
[24-322]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
E
D
P
K
W
E
F
P
R
D
K
L
T
L
G
K
P
L
------
Q
V
V
M
A
E
A
V
G
I
D
K
D
K
P
K
E
A
V
T
V
A
V
K
M
L
K
D
D
A
T
E
K
D
L
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
T
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
A
R
R
P
-------------
E
E
Q
M
T
F
K
D
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
N
N
V
M
K
I
A
D
F
G
L
A
R
D
I
N
N
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
G
G
S
P
Y
P
G
I
P
V
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
L
T
L
T
T
N
-----------------------------------------------------------
98
PsiBlast_CBE
87.63
86%
-118
- C4 -
2PWL
1
FGFR2_HUMAN
B:
[24-321]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
E
D
P
K
W
E
F
P
R
D
K
L
T
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
M
A
E
A
V
G
I
D
K
D
K
P
K
E
A
V
T
V
A
V
K
M
L
K
D
D
A
T
E
K
D
L
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
H
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
A
R
R
P
P
G
------------
E
Q
M
T
F
K
D
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
N
N
V
M
K
I
A
D
F
G
L
A
R
D
I
N
N
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
G
G
S
P
Y
P
G
I
P
V
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
L
T
L
T
T
------------------------------------------------------------
106
PsiBlast_CBE
87.60
74%
-121
* C4 *
4TYJ
2
A:
[5-311]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
G
L
V
S
L
D
L
P
L
D
P
L
W
E
F
P
R
D
R
L
V
L
G
K
P
L
G
E
G
--
G
Q
V
V
R
A
E
A
F
G
M
D
P
A
R
P
D
Q
A
S
T
V
A
V
K
M
L
K
D
N
A
S
D
K
D
L
A
D
L
V
S
E
M
E
V
M
K
L
I
G
R
H
K
N
I
I
N
L
L
G
V
C
T
Q
E
G
P
L
Y
V
I
V
E
C
A
A
K
G
N
L
R
E
F
L
R
A
R
R
P
P
---------------
L
S
F
P
V
L
V
S
C
A
Y
Q
V
A
R
G
M
Q
Y
L
E
S
R
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
N
V
M
K
I
A
D
F
G
L
A
R
---------------
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
I
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
I
P
V
E
E
L
F
S
L
L
R
E
G
H
R
M
D
R
P
P
H
C
P
P
E
L
Y
G
L
M
R
E
C
W
H
A
A
P
S
Q
R
P
T
F
K
Q
L
V
E
A
L
D
K
V
L
L
A
V
S
E
E
----------------------------------------------------------
66
PsiBlast_CBE
87.57
87%
-121
- C4 -
3RI1
1
FGFR2_HUMAN
B:
[13-311]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
E
D
P
K
W
E
F
P
R
D
K
L
T
L
G
K
P
L
G
E
G
C
F
G
Q
V
V
M
A
E
A
V
G
I
D
---
P
K
E
A
V
T
V
A
V
K
M
L
K
D
D
A
T
E
K
D
L
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
A
R
R
P
P
-------------
E
Q
M
T
F
K
D
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
N
N
V
M
K
I
A
D
F
G
L
A
R
D
I
N
N
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
G
G
S
P
Y
P
G
I
P
V
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
L
T
L
T
T
N
-----------------------------------------------------------
74
PsiBlast_CBE
87.52
86%
-122
- C4 -
2PZR
1
FGFR2_HUMAN
A:
[24-321]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
E
D
P
K
W
E
F
P
R
D
K
L
T
L
G
K
P
L
------
Q
V
V
M
A
E
A
V
G
I
D
K
D
K
P
K
E
A
V
T
V
A
V
K
M
L
K
D
D
A
T
E
K
D
L
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
A
R
R
P
P
------------
E
E
Q
M
T
F
K
D
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
N
N
V
M
R
I
A
D
F
G
L
A
R
D
I
N
N
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
G
G
S
P
Y
P
G
I
P
V
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
L
T
L
T
T
------------------------------------------------------------
78
PsiBlast_CBE
87.49
86%
-115
- C4 -
4J97
1
?
C:
[23-320]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
E
D
P
K
W
E
F
P
R
D
K
L
T
L
G
K
P
L
G
---
F
G
Q
V
V
M
A
E
A
V
G
I
D
-----
E
A
V
T
V
A
V
K
M
L
K
D
D
A
T
E
K
D
L
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
A
R
R
P
P
-------
I
N
R
V
P
E
E
Q
M
T
F
K
D
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
N
N
V
M
K
I
A
D
F
G
L
A
R
D
I
N
N
I
D
Y
Y
K
E
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
G
G
S
P
Y
P
G
I
P
V
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
L
T
L
T
-------------------------------------------------------------
89
PsiBlast_CBE
87.43
86%
-120
- C4 -
2PVY
1
?
D:
[23-320]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
E
D
P
K
W
E
F
P
R
D
K
L
T
L
G
K
P
L
------
Q
V
V
M
A
E
A
V
G
I
D
K
D
K
P
K
E
A
V
T
V
A
V
K
M
L
K
D
D
A
T
E
K
D
L
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
A
R
R
P
P
G
---------
V
P
E
E
Q
M
T
F
K
D
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
N
N
V
M
K
I
A
D
F
G
L
A
R
D
I
N
N
I
D
Y
Y
K
N
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
G
G
S
P
Y
P
G
I
P
V
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
L
T
L
T
-------------------------------------------------------------
79
PsiBlast_CBE
87.41
86%
-117
- C4 -
4J97
1
B:
[24-320]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
E
D
P
K
W
E
F
P
R
D
K
L
T
L
G
K
P
L
G
E
---
G
Q
V
V
M
A
E
A
V
G
I
D
-----
E
A
V
T
V
A
V
K
M
L
K
D
D
A
T
E
K
D
L
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
A
R
R
P
P
G
------
I
N
R
V
P
E
E
Q
M
T
F
K
D
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
N
N
V
M
K
I
A
D
F
G
L
A
R
D
I
N
N
I
D
Y
Y
K
E
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
G
G
S
P
Y
P
G
I
P
V
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
L
T
L
T
-------------------------------------------------------------
103
PsiBlast_CBE
87.38
73%
-127
- C4 -
4QQC
1
A:
[14-320]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
L
L
A
G
L
V
S
L
D
L
P
L
D
P
L
W
E
F
P
R
D
R
L
V
L
G
K
P
L
G
E
G
C
F
G
Q
V
V
R
A
E
A
F
G
M
D
-----
Q
A
S
T
V
A
V
K
M
L
K
D
N
A
S
D
K
D
L
A
D
L
V
S
E
M
E
V
M
K
L
I
G
R
H
K
N
I
I
N
L
L
G
V
C
T
Q
E
G
P
L
Y
V
I
V
E
C
A
A
K
G
N
L
R
E
F
L
R
A
R
R
P
P
G
P
-------------
L
S
F
P
V
L
V
S
C
A
Y
Q
V
A
R
G
M
Q
Y
L
E
S
R
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
N
V
M
K
I
A
D
F
G
L
-----------------
L
P
V
K
W
M
A
P
E
A
L
F
D
E
V
Y
T
H
Q
S
D
V
W
S
F
G
I
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
I
P
V
E
E
L
F
S
L
L
R
E
G
H
R
M
D
R
P
P
H
C
P
P
E
L
Y
G
L
M
R
E
C
W
H
A
A
P
S
Q
R
P
T
F
K
Q
L
V
E
A
L
D
K
V
L
L
A
V
-------------------------------------------------------------
85
PsiBlast_CBE
87.36
86%
-118
- C4 -
4J95
1
?
B:
[24-320]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
E
D
P
K
W
E
F
P
R
D
K
L
T
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
M
A
E
A
V
G
I
D
K
D
K
P
K
E
A
V
T
V
A
V
K
M
L
K
D
D
A
T
E
K
D
L
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
A
R
R
P
---------------
Q
M
T
F
K
D
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
N
N
V
M
K
I
A
D
F
G
L
A
R
D
I
N
N
I
D
Y
Y
K
N
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
G
G
S
P
Y
P
G
I
P
V
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
L
T
L
T
-------------------------------------------------------------
102
PsiBlast_CBE
87.13
82%
-115
- C4 -
4K33
1
A:
[25-321]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
A
D
P
K
W
E
L
S
R
A
R
L
T
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
M
A
E
A
I
G
I
D
K
D
R
A
A
K
P
V
T
V
A
V
K
M
L
K
D
D
A
T
D
K
D
L
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
G
G
P
L
Y
V
L
V
E
Y
A
A
K
G
N
L
R
E
F
L
R
A
R
R
P
P
G
L
D
Y
S
F
D
T
S
----
E
Q
L
T
F
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
N
V
M
K
I
A
D
F
G
L
A
R
D
V
H
N
L
D
Y
Y
K
E
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
I
P
V
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
A
N
C
T
H
D
L
Y
M
I
M
R
E
C
W
H
A
A
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
V
L
T
V
T
-------------------------------------------------------------
100
PsiBlast_CBE
87.05
86%
-117
- C4 -
2PY3
1
B:
[24-322]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
E
D
P
K
W
E
F
P
R
D
K
L
T
L
G
K
P
L
G
----
G
Q
V
V
M
A
E
A
V
G
I
D
K
D
K
P
K
E
A
V
T
V
A
V
K
M
L
K
D
D
A
T
E
K
D
L
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
G
Y
A
S
K
G
N
L
R
E
Y
L
R
A
R
R
P
P
G
-----------
E
E
Q
M
T
F
K
D
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
N
N
V
M
K
I
A
D
F
G
L
A
R
D
I
N
N
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
G
G
S
P
Y
P
G
I
P
V
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
L
T
L
T
T
N
-----------------------------------------------------------
87
PsiBlast_CBE
87.01
86%
-121
- C4 -
2Q0B
1
B:
[24-322]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
E
D
P
K
W
E
F
P
R
D
K
L
T
L
G
K
P
L
-----
G
Q
V
V
M
A
E
A
V
G
I
D
K
D
K
P
K
E
A
V
T
V
A
V
K
M
L
K
D
D
A
T
E
K
D
L
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
A
Y
A
S
K
G
N
L
R
E
Y
L
R
A
R
R
P
P
------------
E
E
Q
M
T
F
K
D
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
N
N
V
M
K
I
A
D
F
G
L
A
R
D
I
N
N
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
G
G
S
P
Y
P
G
I
P
V
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
L
T
L
T
T
N
-----------------------------------------------------------
84
PsiBlast_CBE
86.96
86%
-117
- C4 -
4J95
1
?
C:
[24-320]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
E
D
P
K
W
E
F
P
R
D
K
L
T
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
M
A
E
A
V
G
I
D
K
D
K
P
K
E
A
V
T
V
A
V
K
M
L
K
D
D
A
T
E
K
D
L
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
A
R
R
----------------
Q
M
T
F
K
D
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
N
N
V
M
K
I
A
D
F
G
L
A
R
D
I
N
N
I
D
Y
Y
K
N
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
G
G
S
P
Y
P
G
I
P
V
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
L
T
L
T
-------------------------------------------------------------
104
PsiBlast_CBE
86.95
73%
-126
- C4 -
4R6V
1
A:
[14-320]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
L
L
A
G
L
V
S
L
D
L
P
L
D
P
L
W
E
F
P
R
D
R
L
V
L
G
K
P
L
G
E
G
C
F
G
Q
V
V
R
A
E
A
F
G
M
D
-----
Q
A
S
T
V
A
V
K
M
L
K
D
N
A
S
D
K
D
L
A
D
L
V
S
E
M
E
V
M
K
L
I
G
R
H
K
N
I
I
N
L
L
G
V
C
T
Q
E
G
P
L
Y
V
I
L
E
C
A
A
K
G
N
L
R
E
F
L
R
A
R
R
P
P
G
P
-------------
L
S
F
P
V
L
V
S
C
A
Y
Q
V
A
R
G
M
Q
Y
L
E
S
R
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
N
V
M
K
I
A
D
F
G
L
A
-----------------
P
V
K
W
M
A
P
E
A
L
F
D
E
V
Y
T
H
Q
S
D
V
W
S
F
G
I
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
I
P
V
E
E
L
F
S
L
L
R
E
G
H
R
M
D
R
P
P
H
C
P
P
E
L
Y
G
L
M
R
E
C
W
H
A
A
P
S
Q
R
P
T
F
K
Q
L
V
E
A
L
D
K
V
L
L
A
V
-------------------------------------------------------------
105
PsiBlast_CBE
86.93
73%
-124
- C4 -
4QQ5
1
A:
[14-320]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
L
L
A
G
L
V
S
L
D
L
P
L
D
P
L
W
E
F
P
R
D
R
L
V
L
G
K
P
L
G
E
G
C
F
G
Q
V
V
R
A
E
A
F
G
M
D
-----
Q
A
S
T
V
A
V
K
M
L
K
D
N
A
S
D
K
D
L
A
D
L
V
S
E
M
E
V
M
K
L
I
G
R
H
K
N
I
I
N
L
L
G
V
C
T
Q
E
G
P
L
Y
V
I
L
E
C
A
A
K
G
N
L
R
E
F
L
R
A
R
R
P
P
G
P
-------------
L
S
F
P
V
L
V
S
C
A
Y
Q
V
A
R
G
M
Q
Y
L
E
S
R
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
N
V
M
K
I
A
D
F
G
L
A
----------------
L
P
V
K
W
M
A
P
E
A
L
F
D
E
V
Y
T
H
Q
S
D
V
W
S
F
G
I
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
I
P
V
E
E
L
F
S
L
L
R
E
G
H
R
M
D
R
P
P
H
C
P
P
E
L
Y
G
L
M
R
E
C
W
H
A
A
P
S
Q
R
P
T
F
K
Q
L
V
E
A
L
D
K
V
L
L
A
V
-------------------------------------------------------------
75
PsiBlast_CBE
86.87
86%
-115
- C4 -
4J98
1
FGFR2_HUMAN
B:
[17-320]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
G
V
S
E
Y
E
L
P
E
D
P
K
W
E
F
P
R
D
K
L
T
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
M
A
E
A
V
G
I
D
K
D
K
P
K
E
A
V
T
V
A
V
K
M
L
K
D
D
A
T
E
K
D
L
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
A
R
R
P
P
G
M
E
Y
S
Y
D
I
N
R
V
P
E
E
Q
M
T
F
K
D
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
N
N
V
M
K
I
A
D
F
G
L
A
R
D
I
N
N
I
D
Y
Y
K
Q
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
G
G
S
P
Y
P
G
I
P
V
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
L
T
L
T
-------------------------------------------------------------
95
PsiBlast_CBE
86.86
86%
-121
- C4 -
4J99
1
FGFR2_HUMAN
A:
[22-320]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
E
L
P
E
D
P
K
W
E
F
P
R
D
K
L
T
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
M
A
E
A
V
G
I
D
K
D
K
P
K
E
A
V
T
V
A
V
K
M
L
K
D
D
A
T
E
K
D
L
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
A
R
R
P
---------------
Q
M
T
F
K
D
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
N
N
V
M
K
I
A
D
F
G
L
A
R
D
I
N
--
D
Y
Y
K
T
--
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
G
G
S
P
Y
P
G
I
P
V
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
L
T
L
T
-------------------------------------------------------------
68
PsiBlast_CBE
86.83
86%
-117
- C4 -
3CLY
1
FGFR2_HUMAN
A:
[24-328]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
E
D
P
K
W
E
F
P
R
D
K
L
T
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
M
A
E
A
V
G
I
D
K
D
K
P
K
E
A
V
T
V
A
V
K
M
L
K
D
D
A
T
E
K
D
L
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
A
R
R
--------------
E
E
Q
M
T
F
K
D
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
N
N
V
M
K
I
A
D
F
G
L
A
R
D
I
N
N
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
G
G
S
P
Y
P
G
I
P
V
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
L
T
L
T
T
N
E
E
Y
L
D
L
-----------------------------------------------------
96
PsiBlast_CBE
86.47
86%
-112
- C4 -
4J96
1
FGFR2_HUMAN
B:
[18-322]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
V
S
E
Y
E
L
P
E
D
P
K
W
E
F
P
R
D
K
L
T
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
M
A
E
A
V
G
I
D
K
D
K
P
K
E
A
V
T
V
A
V
K
M
L
K
D
D
A
T
E
K
D
L
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
A
R
R
P
P
G
M
E
Y
S
Y
D
I
N
R
V
P
E
E
Q
M
T
F
K
D
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
N
N
V
M
K
I
A
D
F
G
L
A
R
D
I
N
N
I
D
Y
Y
K
M
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
G
G
S
P
Y
P
G
I
P
V
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
L
T
L
T
T
N
-----------------------------------------------------------
80
PsiBlast_CBE
85.93
86%
-119
- C4 -
4J97
1
FGFR2_HUMAN
A:
[24-320]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
E
D
P
K
W
E
F
P
R
D
K
L
T
L
G
K
P
L
G
E
---
G
Q
V
V
M
A
E
A
V
G
I
D
--
K
P
K
E
A
V
T
V
A
V
K
M
L
K
D
D
A
T
E
K
D
L
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
A
R
R
P
P
G
----------
P
E
E
Q
M
T
F
K
D
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
N
N
V
M
K
I
A
D
F
G
L
A
R
D
I
N
N
I
D
Y
Y
K
E
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
G
G
S
P
Y
P
G
I
P
V
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
L
T
L
T
-------------------------------------------------------------