@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : FGFR2_HUMAN: (2015-10-08 )
MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEEPPTKYQISQPEVYVAAPGESLEVRCLLKDAAVISWTKDGVHLGPNNRTVLIGEYLQIKGATPRDSGLYACTASRTVDSETWYFMVNVTDAISSGDDEDDTDGAEDFVSENSNNKRAPYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSINHTYHLDVVERSPHRPILQAGLPANASTVVGGDVEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKAAGVNTTDKEIEVLYIRNVTFEDAGEYTCLAGNSIGISFHSAWLTVLPAPGREKEITASPDYLEIAIYCIGVFLIACMVVTVILCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQVTVSAESSSSMNSNTPLVRITTRLSSTADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNEEYLDLSQPLEQYSPSYPDTRSSCSSGDDSVFSPDPMPYEPCLPQYPHINGSVKT
Atome Classification :
(44 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470........480-........490.......500...---------....510.......520.......530.......540.......550....-...560.......570.......580-.......590..---.....600.......610.......620.......630...-----.---...640.......650.......660.......670.......680.......690.......-700.......-710.......-------720.......730.......740.......750.......760.......770.......780.......790.......800.......810.......820
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MVSW
G
R
F
I
C
L
V
V
V
T
M
A
T
L
SLARPSFSLVEDTTLEPEEPPT
K
Y
QISQP
E
V
Y
V
AAPGE
S
L
E
V
R
C
L
L
KD
A
A
V
I
S
WTKDG
V
H
LGPN
N
R
T
V
L
I
G
E
Y
L
Q
IKGATPRDS
G
L
Y
A
CTASRTVDSE
T
W
Y
F
M
V
NVTDAISSGDDEDDTD
G
A
E
D
F
V
SENSNNKRAPYWT
N
T
E
K
M
E
K
R
L
HAVPAA
N
T
V
K
F
RCPAGGNPM
P
T
M
R
W
L
KN
G
K
E
F
K
Q
E
HRIG
G
Y
K
V
R
N
Q
H
W
S
L
I
M
E
S
VVPSDKG
N
Y
T
C
V
V
ENEYGSI
N
H
T
Y
H
L
D
V
VERSPHR
P
I
L
QAGLPANASTVVGG
D
V
E
F
V
C
K
V
YSDA
Q
P
H
I
Q
W
I
K
H
V
E
KNGSKYGPDG
L
P
Y
L
K
V
L
K
AAGVNTTDK
E
I
E
V
L
Y
I
RNVTFEDAG
E
Y
T
C
LAG
N
S
I
G
I
S
F
HS
A
W
L
T
VLPAPGREKEITASP
D
Y
L
E
I
A
I
Y
C
I
G
V
F
L
I
A
C
M
V
V
T
V
I
L
C
RMKNTTKKPDFSSQ
P
A
V
H
K
L
T
K
RIPL
R
R
Q
V
T
V
SAESSSSMNSNT
P
L
V
R
I
T
T
RLSSTADTPMLAGVSEYELPED-PKWEFPRDKL--TLGKPLGEGC
F
G
Q
V
V
M
A
E
AVGIDK---------DKP
K
E
A
V
T
V
A
V
K
M
LKDDA
T
E
K
D
L
S
D
L
V
S
E
M
E
M
M
K
M
I
GK
H
K
N
I
I
N
L
L
G
A
CTQ-DG
P
L
Y
V
I
V
E
YASKG
N
L
R
E
Y
L
R
ARRPP-GMEYSYDINRV
P
---
E
E
Q
M
T
F
K
D
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
AAR
N
V
L
VT-----E---N
N
V
M
K
I
ADFGLARDINNI
D
Y
Y
K
KTTNGRL
P
V
K
WM
A
P
E
A
L
F
D
R
V
Y
THQ
S
D
V
W
S
F
G
V
L
M
W
E
I
F
TL-GGSPYPGI
P
V
-
E
E
L
F
K
L
L
KEG-------HRMDKPA
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
AVPSQR
P
T
F
K
Q
L
V
E
D
L
D
R
I
L
TLTTNEEYL
D
L
S
Q
P
L
E
Q
YSPSYPDTRSSCSSGDDSVFSPDPMPYEPCLPQYPHINGSVKT
115
HHSearch
92.90
99%
-118
- C3 -
2PVF
1
A:
[23-321]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
E
D
-
P
K
W
E
F
P
R
D
K
L
--
T
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
M
A
E
A
V
G
I
D
K
---------
D
K
P
---
V
T
V
A
V
K
M
L
K
D
D
A
T
E
K
D
L
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
A
R
R
P
P
-
G
M
E
Y
S
Y
-----------
Q
M
T
F
K
D
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
-----
E
---
N
N
V
M
K
I
A
D
F
G
L
A
R
D
I
N
N
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
I
P
V
-
E
E
L
F
K
L
L
K
E
G
-------
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
L
T
L
T
T
--------------------------------------------------------
90
PsiBlast_CBE
91.32
86%
-127
- C3 -
4WUN
1
B:
[7-308]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
E
Y
E
L
P
E
D
-
P
R
W
E
L
P
R
D
R
L
--
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
------------
K
P
N
R
V
T
K
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
P
P
------------------
Q
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
-----
E
---
D
N
V
M
K
I
A
D
F
G
L
-----------------
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
-
E
E
L
F
K
L
L
K
E
G
-------
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
A
L
T
S
--------------------------------------------------------
79
PsiBlast_CBE
91.26
87%
-117
- C3 -
4NKA
3
FGFR1_HUMAN
A:
[8-309]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
E
D
-
P
R
W
E
L
P
R
D
R
L
--
V
L
G
K
P
L
G
E
----
Q
V
V
L
A
E
A
I
G
L
D
K
---------
D
K
P
N
R
V
T
K
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
P
P
----------------
E
E
Q
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
-----
E
---
D
N
V
M
K
I
A
D
F
G
-------
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
-
E
E
L
F
K
L
L
K
E
G
-------
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
A
L
T
S
N
Q
E
-----------------------------------------------------
67
PsiBlast_CBE
91.08
87%
-116
- C3 -
4V05
4
FGFR1_HUMAN
A:
[8-309]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
E
D
-
P
R
W
E
L
P
R
D
R
L
--
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
D
K
---------
D
K
P
N
R
V
T
K
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
P
P
-
G
--------------
E
E
Q
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
-----
E
---
D
N
V
M
K
I
A
D
F
G
L
A
R
----
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
-
E
E
L
F
K
L
L
K
E
G
-------
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
A
L
T
S
N
Q
E
-----------------------------------------------------
92
PsiBlast_CBE
90.91
86%
-115
- C3 -
4RWK
1
B:
[11-315]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
V
S
E
Y
E
L
P
E
D
-
P
R
W
E
L
P
R
D
R
L
--
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
D
K
---------
D
K
P
N
R
V
T
K
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
-
D
G
P
L
Y
V
I
M
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
--------------------
Q
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
-----
E
---
D
N
V
M
K
I
A
D
F
G
L
A
-----
I
D
Y
Y
K
K
T
--
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
-
E
E
L
F
K
L
L
K
E
G
-------
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
A
L
T
S
N
-------------------------------------------------------
101
PsiBlast_CBE
90.71
86%
-118
- C3 -
3C4F
1
FGFR1_HUMAN
A:
[1-302]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
E
D
-
P
R
W
E
L
P
R
D
R
L
--
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
D
K
---------
D
K
P
N
R
V
T
K
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
P
P
----------------
E
E
Q
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
-----
E
---
D
N
V
M
K
I
A
D
F
G
L
A
R
D
I
H
H
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
-
E
E
L
F
K
L
L
K
E
G
-------
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
A
L
T
S
N
Q
E
-----------------------------------------------------
98
PsiBlast_CBE
90.07
87%
-117
- C3 -
3RHX
5
FGFR1_HUMAN
A:
[5-305]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
E
D
-
P
R
W
E
L
P
R
D
R
L
--
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
D
K
---------
D
K
P
N
R
V
T
K
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
P
P
----------------
E
E
Q
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
-----
E
---
D
N
V
M
K
I
A
D
F
G
L
A
R
D
I
H
H
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
-
E
E
L
F
K
L
L
K
E
G
-------
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
A
L
T
S
N
Q
------------------------------------------------------
81
PsiBlast_CBE
90.03
87%
-119
- C3 -
4NK9
5
FGFR1_HUMAN
A:
[8-309]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
E
D
-
P
R
W
E
L
P
R
D
R
L
--
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
D
----------
D
K
P
N
R
V
T
K
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
P
P
-----------------
E
Q
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
-----
E
---
D
N
V
M
K
I
A
D
F
G
-------
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
-
E
E
L
F
K
L
L
K
E
G
-------
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
A
L
T
S
N
Q
E
-----------------------------------------------------
71
PsiBlast_CBE
90.02
87%
-119
- C3 -
4V01
7
FGFR1_HUMAN
A:
[9-309]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
E
D
-
P
R
W
E
L
P
R
D
R
L
--
V
L
G
K
P
L
G
----
G
Q
V
V
L
A
E
A
I
G
L
D
K
-----------
P
N
R
V
T
K
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
P
P
------------------
Q
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
-----
E
---
D
N
V
M
K
I
A
D
F
--------
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
-
E
E
L
F
K
L
L
K
E
G
-------
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
A
L
T
S
N
Q
E
-----------------------------------------------------
80
PsiBlast_CBE
89.74
87%
-117
- C3 -
4NK9
2
B:
[4-309]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
S
E
Y
E
L
P
E
D
-
P
R
W
E
L
P
R
D
R
L
--
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
D
K
-----------
P
N
R
V
T
K
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
P
P
------------------
Q
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
-----
E
---
D
N
V
M
K
I
A
D
F
G
--------
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
-
E
E
L
F
K
L
L
K
E
G
-------
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
A
L
T
S
N
Q
E
-----------------------------------------------------
78
PsiBlast_CBE
89.55
87%
-116
- C3 -
4NKA
2
B:
[2-309]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
G
V
S
E
Y
E
L
P
E
D
-
P
R
W
E
L
P
R
D
R
L
--
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
D
K
-----------
P
N
R
V
T
K
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
P
P
-----------------
E
Q
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
-----
E
---
D
N
V
M
K
I
A
D
F
------
H
H
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
-
E
E
L
F
K
L
L
K
E
G
-------
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
A
L
T
S
N
Q
E
-----------------------------------------------------
84
PsiBlast_CBE
89.52
87%
-121
- C3 -
4F64
3
B:
[5-305]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
E
Y
E
L
P
E
D
-
P
R
W
E
L
P
R
D
R
L
--
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
-------------
P
N
R
V
T
K
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
--------------------
Q
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
-----
E
---
D
N
V
M
K
I
A
D
F
G
L
A
------
D
Y
Y
K
K
---
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
-
E
E
L
F
K
L
L
K
E
G
-------
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
A
L
T
---------------------------------------------------------
88
PsiBlast_CBE
89.43
87%
-120
- C3 -
4ZSA
1
B:
[5-304]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
Y
E
L
P
E
D
-
P
R
W
E
L
P
R
D
R
L
--
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
D
K
---------
D
K
P
N
R
V
T
K
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
P
P
----------------
E
E
Q
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
-----
E
---
D
N
V
M
K
I
A
D
F
G
L
------
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
-
E
E
L
F
K
L
L
K
E
G
-------
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
A
L
T
---------------------------------------------------------
77
PsiBlast_CBE
89.19
87%
-122
- C3 -
4NKS
1
FGFR1_HUMAN
A:
[9-306]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
E
D
-
P
R
W
E
L
P
R
D
R
L
--
V
L
G
K
P
L
-----
G
Q
V
V
L
A
E
A
I
----------------
N
R
V
T
K
V
A
V
K
M
L
K
-
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
P
P
------------------
Q
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
-----
E
---
D
N
V
M
K
I
A
D
F
G
L
------
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
-
E
E
L
F
K
L
L
K
E
G
-------
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
A
L
T
S
--------------------------------------------------------
94
PsiBlast_CBE
89.06
86%
-113
- C3 -
5A4C
7
?
B:
[1-307]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
A
S
E
Y
E
L
P
E
D
-
P
R
W
E
L
P
R
D
R
L
--
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
D
------------
P
N
R
V
T
K
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
P
P
-----------------
E
Q
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
-----
E
---
D
N
V
M
K
I
A
D
F
G
L
A
-----
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
-
E
E
L
F
K
L
L
K
E
G
-------
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
A
L
T
S
N
Q
E
-----------------------------------------------------
100
PsiBlast_CBE
88.76
86%
-117
- C3 -
3C4F
1
B:
[1-302]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
E
D
-
P
R
W
E
L
P
R
D
R
L
--
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
D
K
---------
D
K
P
N
R
V
T
K
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
P
P
----------------
E
E
Q
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
-----
E
---
D
N
V
M
K
I
A
D
F
G
L
A
R
D
I
H
H
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
-
E
E
L
F
K
L
L
K
E
G
-------
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
A
L
T
S
N
Q
E
-----------------------------------------------------
75
PsiBlast_CBE
88.51
87%
-109
- C3 -
4UWB
4
?
A:
[8-309]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
E
D
-
P
R
W
E
L
P
R
D
R
L
--
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
D
K
---------
D
K
P
N
R
V
T
K
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
P
P
-
G
L
E
Y
S
--
P
S
H
N
P
---
E
E
Q
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
-----
E
---
D
N
V
M
K
I
A
D
F
G
L
A
R
D
-
H
H
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
-
E
E
L
F
K
L
L
K
E
G
-------
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
A
L
T
S
N
Q
E
-----------------------------------------------------
83
PsiBlast_CBE
88.44
87%
-116
- C3 -
4F65
6
FGFR1_HUMAN
A:
[8-309]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
E
D
-
P
R
W
E
L
P
R
D
R
L
--
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
D
K
-----------
P
N
R
V
T
K
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
P
P
------------
P
---
E
E
Q
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
-----
E
---
D
N
V
M
K
I
A
D
F
----------
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
-
E
E
L
F
K
L
L
K
E
G
-------
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
A
L
T
S
N
Q
E
-----------------------------------------------------
76
PsiBlast_CBE
88.32
87%
-122
- C3 -
4NKS
1
B:
[5-305]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
E
Y
E
L
P
E
D
-
P
R
W
E
L
P
R
D
R
L
--
V
L
G
K
P
L
G
E
G
A
-
G
Q
V
V
L
A
E
A
I
G
L
-------------
P
N
R
V
T
K
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
--------------------
Q
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
-----
E
---
D
N
V
M
K
I
A
D
F
G
L
A
------
D
Y
Y
K
K
---
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
-
E
E
L
F
K
L
L
K
E
G
-------
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
A
L
T
---------------------------------------------------------
82
PsiBlast_CBE
88.15
87%
-118
- C3 -
4F65
4
B:
[4-307]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
S
E
Y
E
L
P
E
D
-
P
R
W
E
L
P
R
D
R
L
--
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
D
------------
P
N
R
V
T
K
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
P
-------------------
Q
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
-----
E
---
D
N
V
M
K
I
A
D
F
-------
H
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
-
E
E
L
F
K
L
L
K
E
G
-------
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
A
L
T
S
N
-------------------------------------------------------
86
PsiBlast_CBE
87.74
87%
-123
- C3 -
4F63
3
B:
[5-305]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
E
Y
E
L
P
E
D
-
P
R
W
E
L
P
R
D
R
L
--
V
L
G
K
P
L
G
E
G
A
-
G
Q
V
V
L
A
E
A
I
G
L
-------------
P
N
R
V
T
K
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
--------------------
Q
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
-----
E
---
D
N
V
M
K
I
A
D
F
G
L
A
------
D
Y
Y
K
K
---
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
-
E
E
L
F
K
L
L
K
E
G
-------
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
A
L
T
---------------------------------------------------------
102
PsiBlast_CBE
87.35
74%
-126
- C3 -
4QQC
1
A:
[14-320]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
L
L
A
G
L
V
S
L
D
L
P
L
D
-
P
L
W
E
F
P
R
D
R
L
--
V
L
G
K
P
L
G
E
G
C
F
G
Q
V
V
R
A
E
A
F
G
M
D
--------------
Q
A
S
T
V
A
V
K
M
L
K
D
N
A
S
D
K
D
L
A
D
L
V
S
E
M
E
V
M
K
L
I
G
R
H
K
N
I
I
N
L
L
G
V
C
T
Q
-
E
G
P
L
Y
V
I
V
E
C
A
A
K
G
N
L
R
E
F
L
R
A
R
R
P
P
-
G
P
----------------
L
S
F
P
V
L
V
S
C
A
Y
Q
V
A
R
G
M
Q
Y
L
E
S
R
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
-----
E
---
D
N
V
M
K
I
A
D
F
G
L
-----------------
L
P
V
K
W
M
A
P
E
A
L
F
D
E
V
Y
T
H
Q
S
D
V
W
S
F
G
I
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
I
P
V
-
E
E
L
F
S
L
L
R
E
G
-------
H
R
M
D
R
P
P
H
C
P
P
E
L
Y
G
L
M
R
E
C
W
H
A
A
P
S
Q
R
P
T
F
K
Q
L
V
E
A
L
D
K
V
L
L
A
V
---------------------------------------------------------
99
PsiBlast_CBE
87.30
84%
-114
- C3 -
4K33
1
A:
[25-321]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
A
D
-
P
K
W
E
L
S
R
A
R
L
--
T
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
M
A
E
A
I
G
I
D
K
---------
D
R
A
A
K
P
V
T
V
A
V
K
M
L
K
D
D
A
T
D
K
D
L
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
-
G
G
P
L
Y
V
L
V
E
Y
A
A
K
G
N
L
R
E
F
L
R
A
R
R
P
P
-
G
L
D
Y
S
F
D
T
S
-------
E
Q
L
T
F
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
-----
E
---
D
N
V
M
K
I
A
D
F
G
L
A
R
D
V
H
N
L
D
Y
Y
K
E
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
I
P
V
-
E
E
L
F
K
L
L
K
E
G
-------
H
R
M
D
K
P
A
N
C
T
H
D
L
Y
M
I
M
R
E
C
W
H
A
A
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
V
L
T
V
T
---------------------------------------------------------
95
PsiBlast_CBE
87.20
86%
-109
- C3 -
5A4C
6
?
A:
[6-307]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
E
D
-
P
R
W
E
L
P
R
D
R
L
--
V
L
G
K
P
L
G
E
--
F
G
Q
V
V
L
A
E
A
I
G
L
D
K
---------
D
K
P
N
R
V
T
K
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
P
P
-
G
L
E
Y
S
Y
N
P
S
H
N
P
---
E
E
Q
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
-----
E
---
D
N
V
M
K
I
A
D
F
G
L
------
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
-
E
E
L
F
K
L
L
K
E
G
-------
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
A
L
T
S
N
Q
E
-----------------------------------------------------
96
PsiBlast_CBE
87.04
85%
-116
- C3 -
3GQI
2
A:
[16-322]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
E
D
-
P
R
W
E
L
P
R
D
R
L
--
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
D
K
---------
D
K
P
N
R
V
T
K
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
P
P
-
G
L
E
F
S
F
N
P
S
H
N
P
---
E
E
Q
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
-----
E
---
D
N
V
M
K
I
A
D
F
G
L
A
R
D
I
H
H
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
-
E
E
L
F
K
L
L
K
E
G
-------
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
A
L
T
S
N
Q
E
Y
L
D
L
S
------------------------------------------------
97
PsiBlast_CBE
86.78
87%
-118
- C3 -
3RHX
3
B:
[2-302]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
E
Y
E
L
P
E
D
-
P
R
W
E
L
P
R
D
R
L
--
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
-------------
P
N
R
V
T
K
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
--------------------
Q
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
-----
E
---
D
N
V
M
K
I
A
D
F
G
L
A
------
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
-
E
E
L
F
K
L
L
K
E
G
-------
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
A
L
T
---------------------------------------------------------
93
PsiBlast_CBE
86.60
86%
-107
- C3 -
4RWK
1
FGFR1_HUMAN
A:
[9-316]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
A
G
V
S
E
Y
E
L
P
E
D
-
P
R
W
E
L
P
R
D
R
L
--
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
D
K
---------
D
K
P
N
R
V
T
K
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
-
D
G
P
L
Y
V
I
M
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
P
P
-
G
L
E
Y
S
Y
N
P
S
H
N
P
---
E
E
Q
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
-----
E
---
D
N
V
M
K
I
A
D
F
G
L
A
R
D
I
H
H
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
-
E
E
L
F
K
L
L
K
E
G
-------
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
A
L
T
S
N
Q
------------------------------------------------------
72
PsiBlast_CBE
86.51
87%
-113
- C3 -
4UWC
9
?
B:
[3-308]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
V
S
E
Y
E
L
P
E
D
-
P
R
W
E
L
P
R
D
R
L
--
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
D
K
-----------
P
N
R
V
T
K
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
P
P
-
G
L
E
Y
S
Y
---
H
N
P
---
E
E
Q
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
-----
E
---
D
N
V
M
K
I
A
D
F
G
L
A
R
D
I
H
H
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
-
E
E
L
F
K
L
L
K
E
G
-------
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
A
L
T
S
N
Q
------------------------------------------------------
103
PsiBlast_CBE
86.30
74%
-126
- C3 -
4R6V
1
A:
[14-320]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
L
L
A
G
L
V
S
L
D
L
P
L
D
-
P
L
W
E
F
P
R
D
R
L
--
V
L
G
K
P
L
G
E
G
C
F
G
Q
V
V
R
A
E
A
F
G
M
D
--------------
Q
A
S
T
V
A
V
K
M
L
K
D
N
A
S
D
K
D
L
A
D
L
V
S
E
M
E
V
M
K
L
I
G
R
H
K
N
I
I
N
L
L
G
V
C
T
Q
-
E
G
P
L
Y
V
I
L
E
C
A
A
K
G
N
L
R
E
F
L
R
A
R
R
P
P
-
G
P
----------------
L
S
F
P
V
L
V
S
C
A
Y
Q
V
A
R
G
M
Q
Y
L
E
S
R
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
-----
E
---
D
N
V
M
K
I
A
D
F
G
L
A
-----------------
P
V
K
W
M
A
P
E
A
L
F
D
E
V
Y
T
H
Q
S
D
V
W
S
F
G
I
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
I
P
V
-
E
E
L
F
S
L
L
R
E
G
-------
H
R
M
D
R
P
P
H
C
P
P
E
L
Y
G
L
M
R
E
C
W
H
A
A
P
S
Q
R
P
T
F
K
Q
L
V
E
A
L
D
K
V
L
L
A
V
---------------------------------------------------------
74
PsiBlast_CBE
85.76
87%
-109
- C3 -
4UWB
3
?
B:
[3-309]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
V
S
E
Y
E
L
P
E
D
-
P
R
W
E
L
P
R
D
R
L
--
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
D
K
-----------
P
N
R
V
T
K
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
P
P
-
G
L
E
Y
S
Y
---
H
N
P
---
E
E
Q
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
-----
E
---
D
N
V
M
K
I
A
D
F
G
L
A
R
---
H
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
-
E
E
L
F
K
L
L
K
E
G
-------
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
A
L
T
S
N
Q
E
-----------------------------------------------------
116
HHSearch
85.14
85%
-109
- C3 -
3TT0
1
FGFR1_HUMAN
A:
[54-358]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
E
Y
E
L
P
E
D
-
P
R
W
E
L
P
R
D
R
L
--
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
D
K
---------
D
K
P
N
R
V
T
K
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
P
P
-
G
L
E
Y
S
Y
N
P
S
H
N
P
---
E
E
Q
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
-----
E
---
D
N
V
M
K
I
A
D
F
G
L
A
R
D
I
H
H
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
-
E
E
L
F
K
L
L
K
E
G
-------
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
A
L
T
S
N
Q
E
-----------------------------------------------------
91
PsiBlast_CBE
83.92
86%
-113
- C3 -
4WUN
1
FGFR1_HUMAN
A:
[11-311]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
E
D
-
P
R
W
E
L
P
R
D
R
L
--
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
D
K
---------
D
K
P
N
R
V
T
K
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
P
P
--
L
E
Y
S
Y
N
P
S
H
N
P
---
E
E
Q
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
-----
E
---
D
N
V
M
K
I
A
D
F
G
------------------
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
-
E
E
L
F
K
L
L
K
E
G
-------
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
A
L
T
S
N
Q
E
-----------------------------------------------------
122
HHSearch
82.84
57%
-110
- C3 -
3VHE
1
A:
[9-355]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
L
P
Y
D
A
S
K
W
E
F
P
R
D
R
L
--
K
L
G
K
P
L
G
R
G
A
F
G
Q
V
I
E
A
D
A
F
G
I
D
K
---------
T
A
T
--
C
R
T
V
A
V
K
M
L
K
E
G
A
T
H
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
K
P
G
G
P
L
M
V
I
V
E
F
C
K
F
G
N
L
S
T
Y
L
R
S
K
R
N
E
-
F
V
P
Y
K
-------DLY
K
D
F
L
T
L
E
H
L
I
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
-----
E
---
K
N
V
V
K
I
C
D
F
G
L
A
R
D
I
Y
K
D
P
D
Y
V
R
K
--
A
R
L
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
A
S
P
Y
P
G
V
K
I
D
E
E
F
C
R
R
L
K
E
G
-------
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
E
H
L
G
N
L
L
Q
A
N
A
Q
-------------------------------------------------------
121
HHSearch
77.50
51%
-105
- C3 -
1T46
1
?
A:
[11-311]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
P
Y
D
-
H
K
W
E
F
P
R
N
R
L
--
S
F
G
K
T
L
G
A
G
A
F
G
K
V
V
E
A
T
A
Y
G
L
I
K
---------
S
--
D
A
A
M
T
V
A
V
K
M
L
K
P
S
A
H
L
T
E
R
E
A
L
M
S
E
L
K
V
L
S
Y
L
G
N
H
M
N
I
V
N
L
L
G
A
C
T
I
-
G
G
P
T
L
V
I
T
E
Y
C
C
Y
G
D
L
L
N
F
L
R
R
K
R
D
S
-
F
---------------
L
A
L
D
L
E
D
L
L
S
F
S
Y
Q
V
A
K
G
M
A
F
L
A
S
K
N
C
I
H
R
D
L
A
A
R
N
I
L
L
T
-----
H
---
G
R
I
T
K
I
C
D
F
G
L
A
R
D
I
K
N
D
S
N
Y
V
V
K
G
N
A
R
L
P
V
K
W
M
A
P
E
S
I
F
N
C
V
Y
T
F
E
S
D
V
W
S
Y
G
I
F
L
W
E
L
F
S
L
-
G
S
S
P
Y
P
G
M
P
V
D
S
K
F
Y
K
M
I
K
E
G
-------
F
R
M
L
S
P
E
H
A
P
A
E
M
Y
D
I
M
K
T
C
W
D
A
D
P
L
K
R
P
T
F
K
Q
I
V
Q
L
I
E
K
Q
I
S
E
S
T
N
-------------------------------------------------------
117
HHSearch
75.58
54%
-106
- C3 -
4CKJ
16
A:
[7-310]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
D
A
F
K
I
L
E
D
-
P
K
W
E
F
P
R
K
N
L
--
V
L
G
K
T
L
G
E
G
E
F
G
K
V
V
K
A
T
A
F
H
L
K
G
---------
R
--
A
G
Y
T
T
V
A
V
K
M
L
K
E
N
A
S
P
S
E
L
R
D
L
L
S
E
F
N
V
L
K
Q
V
-
N
H
P
H
V
I
K
L
Y
G
A
C
S
Q
-
D
G
P
L
L
L
I
V
E
Y
A
K
Y
G
S
L
R
G
F
L
R
E
S
R
K
V
-----------------
R
A
L
T
M
G
D
L
I
S
F
A
W
Q
I
S
Q
G
M
Q
Y
L
A
E
M
K
L
V
H
R
D
L
A
A
R
N
I
L
V
A
-----
E
---
G
R
K
M
K
I
S
D
F
G
L
S
R
D
V
Y
E
E
D
S
Y
V
K
R
S
Q
G
R
I
P
V
K
W
M
A
I
E
S
L
F
D
H
I
Y
T
T
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
V
T
L
-
G
G
N
P
Y
P
G
I
P
P
-
E
R
L
F
N
L
L
K
T
G
-------
H
R
M
E
R
P
D
N
C
S
E
E
M
Y
R
L
M
L
Q
C
W
K
Q
E
P
D
K
R
P
V
F
A
D
I
S
K
D
L
E
K
M
M
V
K
R
R
--------------------------------------------------------
118
HHSearch
74.99
57%
-109
- C3 -
2XIR
1
A:
[15-311]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
Y
D
A
S
K
W
E
F
P
R
D
R
L
--
K
L
G
K
P
L
G
R
G
A
F
G
Q
V
I
E
A
D
A
F
G
I
D
K
---------
T
A
T
C
--
R
T
V
A
V
K
M
L
K
E
G
A
T
H
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
K
P
G
G
P
L
M
V
I
V
E
F
C
K
F
G
N
L
S
T
Y
L
R
S
K
R
N
E
-
F
V
P
Y
-------
Y
---
K
D
F
L
T
L
E
H
L
I
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
-----
E
---
K
N
V
V
K
I
C
D
F
G
L
A
R
D
I
Y
K
D
P
D
Y
V
R
K
G
D
A
R
L
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
A
S
P
Y
P
G
V
K
I
D
E
E
F
C
R
R
L
K
E
G
-------
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
E
H
L
G
N
L
L
Q
A
N
A
--------------------------------------------------------
123
HHSearch
71.94
49%
-104
- C3 -
2I1M
1
A:
[34-325]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
P
Y
N
-
E
K
W
E
F
P
R
N
N
L
--
Q
F
G
K
T
L
G
A
G
A
F
G
K
V
V
E
A
T
A
F
G
L
G
K
---------
E
--
D
A
V
L
K
V
A
V
K
M
L
K
S
T
A
H
A
D
E
K
E
A
L
M
S
E
L
K
I
M
S
H
L
G
Q
H
E
N
I
V
N
L
L
G
A
C
T
H
-
G
G
P
V
L
V
I
T
E
Y
C
C
Y
G
D
L
L
N
F
L
R
R
K
S
R
V
L
E
T
D
-------------
S
T
A
S
T
R
D
L
L
H
F
S
S
Q
V
A
Q
G
M
A
F
L
A
S
K
N
C
I
H
R
D
V
A
A
R
N
V
L
L
T
-----
N
---
G
H
V
A
K
I
G
D
F
G
L
A
R
D
I
M
N
D
S
N
Y
I
V
K
G
N
A
R
L
P
V
K
W
M
A
P
E
S
I
F
D
C
V
Y
T
V
Q
S
D
V
W
S
Y
G
I
L
L
W
E
I
F
S
L
-
G
L
N
P
Y
P
G
I
L
V
N
S
K
F
Y
K
L
V
K
D
G
-------
Y
Q
M
A
Q
P
A
F
A
P
K
N
I
Y
S
I
M
Q
A
C
W
A
L
E
P
T
H
R
P
T
F
Q
Q
I
C
S
F
L
Q
E
Q
A
Q
E
D
R
R
E
R
-----------------------------------------------------
133
HHSearch
70.52
43%
-113
- C3 -
3ZBF
1
A:
[28-314]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
A
F
P
R
E
K
L
--
T
L
R
L
L
L
G
S
---
G
E
V
Y
E
G
T
A
V
D
I
L
G
---------
V
-
G
S
G
E
I
K
V
A
V
K
T
L
K
K
G
S
T
D
Q
E
K
I
E
F
L
K
E
A
H
L
M
S
K
F
-
N
H
P
N
I
L
K
Q
L
G
V
C
L
L
-
N
E
P
Q
Y
I
I
L
E
L
M
E
G
G
D
L
L
T
Y
L
R
K
A
R
M
A
-
T
---------
F
Y
---
G
P
L
L
T
L
V
D
L
V
D
L
C
V
D
I
S
K
G
C
V
Y
L
E
R
M
H
F
I
H
R
D
L
A
A
R
N
C
L
V
S
VKDYT
S
---
P
R
I
V
K
I
G
D
F
G
L
A
R
D
I
Y
------------
L
P
V
R
W
M
A
P
E
S
L
M
D
G
I
F
T
T
Q
S
D
V
W
S
F
G
I
L
I
W
E
I
L
T
L
-
G
H
Q
P
Y
P
A
H
S
N
-
L
D
V
L
N
Y
V
Q
T
G
-------
G
R
L
E
P
P
R
N
C
P
D
D
L
W
N
L
M
T
Q
C
W
A
Q
E
P
D
Q
R
P
T
F
H
R
I
Q
D
Q
L
Q
L
F
R
N
F
F
L
N
S
I
Y
K
S
R
-------------------------------------------------
131
HHSearch
70.47
36%
-111
* C3 *
4AOJ
1
NTRK1_HUMAN
A:
[33-318]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
-
C
V
H
H
I
K
R
R
D
I
--
V
L
K
W
E
L
G
E
G
A
F
G
K
V
F
L
A
E
C
H
N
L
L
P
--------------
K
M
L
V
A
V
K
A
L
K
E
A
-
S
E
S
A
R
Q
D
F
Q
R
E
A
E
L
L
T
M
L
-
Q
H
Q
H
I
V
R
F
F
G
V
C
T
E
-
G
R
P
L
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
R
S
H
G
P
D
----------------
P
G
P
L
G
L
G
Q
L
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
G
-----
Q
---
G
L
V
V
K
I
G
D
F
G
----------------
T
M
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
Y
-
G
K
Q
P
W
Y
Q
L
S
N
-
T
E
A
I
D
C
I
T
Q
G
-------
R
E
L
E
R
P
R
A
C
P
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
H
A
R
L
Q
A
L
A
Q
A
P
P
--------------------------------------------------------
134
HHSearch
68.75
36%
-108
- C3 -
3C1X
1
A:
[78-371]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
V
-
Q
H
V
V
I
G
P
S
S
L
I
V
H
F
N
E
V
I
G
R
G
H
F
G
C
V
Y
H
G
T
L
L
-------------
D
N
D
G
K
K
I
H
C
A
V
K
S
L
N
R
I
T
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
-
S
H
P
N
V
L
S
L
L
G
I
C
L
R
S
E
G
S
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
R
N
E
T
H
-------------------
N
P
T
V
K
D
L
I
G
F
G
L
Q
V
A
K
G
M
K
F
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
-----
E
---
K
F
T
V
K
V
A
D
F
-------------------
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
-
G
A
P
P
Y
P
D
V
N
T
-
F
D
I
T
V
Y
L
L
Q
G
-------
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
L
V
S
R
I
S
A
I
F
S
T
F
I
G
E
H
Y
V
H
V
N
A
T
Y
V
N
V
K
-----------------------------------------
128
HHSearch
67.41
38%
-99
- C3 -
4CLJ
1
A:
[24-316]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
E
V
P
R
K
N
I
--
T
L
I
R
G
L
G
H
G
A
F
G
E
V
Y
E
G
Q
V
S
------------------
P
L
Q
V
A
V
K
T
L
P
E
V
C
S
E
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
-
N
H
Q
N
I
V
R
C
I
G
V
S
L
Q
-
S
L
P
R
F
I
L
M
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
P
R
-
P
S
---------
Q
---
P
S
S
L
A
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
-----
C
PGP
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
------
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
Y
M
P
Y
P
S
K
S
N
-
Q
E
V
L
E
F
V
T
S
G
-------
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
R
I
E
Y
C
---
T
Q
D
P
D
V
I
N
T
A
L
P
I
E
Y
G
------------------------------------------
130
HHSearch
67.16
37%
-104
- C3 -
4BKJ
10
DDR1_HUMAN
A:
[2-307]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
-
P
R
V
D
F
P
R
S
R
L
--
R
F
K
E
K
L
G
E
G
Q
F
G
E
V
H
L
C
E
V
D
S
P
Q
D
LVSLDFPLN
V
R
K
G
H
P
L
L
V
A
V
K
I
L
R
P
D
A
T
K
N
A
R
N
D
F
L
K
E
V
K
I
M
S
R
L
-
K
D
P
N
I
I
R
L
L
G
V
C
V
Q
-
D
D
P
L
C
M
I
T
D
Y
M
E
N
G
D
L
N
Q
F
L
S
A
H
Q
L
E
-
D
---------------
P
T
I
S
Y
P
M
L
L
H
V
A
A
Q
I
A
S
G
M
R
Y
L
A
T
L
N
F
V
H
R
D
L
A
T
R
N
C
L
V
G
-----
E
---
N
F
T
I
K
I
A
D
F
G
M
S
R
N
L
Y
A
G
D
Y
Y
----
R
A
V
L
P
I
R
W
M
A
W
E
C
I
L
M
G
K
F
T
T
A
S
D
V
W
A
F
G
V
T
L
W
E
V
L
M
L
C
R
A
Q
P
F
G
Q
L
T
D
-
E
Q
V
I
E
N
A
G
E
F
F
R
DQGRQ
V
Y
L
S
R
P
P
A
C
P
Q
G
L
Y
E
L
M
L
R
C
W
S
R
E
S
E
Q
R
P
P
F
S
Q
L
H
R
F
L
A
E
D
A
L
N
T
V
--------------------------------------------------------
125
HHSearch
66.70
38%
-108
- C3 -
3CBL
3
A:
[106-373]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-
D
K
W
V
L
N
H
E
D
L
--
V
L
G
E
Q
I
G
R
G
N
F
G
E
V
F
S
G
R
L
R
A
-------------
D
---
N
T
L
V
A
V
K
S
C
R
E
T
L
P
P
D
L
K
A
K
F
L
Q
E
A
R
I
L
K
Q
Y
-
S
H
P
N
I
V
R
L
I
G
V
C
T
Q
-
K
Q
P
I
Y
I
V
M
E
L
V
Q
G
G
D
F
L
T
F
L
R
T
E
G
-------------------
A
R
L
R
V
K
T
L
L
Q
M
V
G
D
A
A
A
G
M
E
Y
L
E
S
K
C
C
I
H
R
D
L
A
A
R
N
C
L
V
T
-----
E
---
K
N
V
L
K
I
S
D
F
G
M
S
R
E
E
A
D
G
V
Y
A
A
S
G
G
L
R
Q
V
P
V
K
W
T
A
P
E
A
L
N
Y
G
R
Y
S
S
E
S
D
V
W
S
F
G
I
L
L
W
E
T
F
S
L
-
G
A
S
P
Y
P
N
L
S
N
-
Q
Q
T
R
E
F
V
E
K
G
-------
G
R
L
P
C
P
E
L
C
P
D
A
V
F
R
L
M
E
Q
C
W
A
Y
E
P
G
Q
R
P
S
F
S
T
I
Y
Q
E
L
Q
S
I
R
K
R
H
---------------------------------------------------------
126
HHSearch
63.73
38%
-95
- C3 -
3L9P
4
A:
[65-356]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
E
V
P
R
K
N
I
--
T
L
I
R
G
L
G
H
G
A
F
G
E
V
Y
E
G
Q
V
S
G
----------------
S
P
L
Q
V
A
V
K
T
L
P
E
V
C
S
E
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
-
N
H
Q
N
I
V
R
C
I
G
V
S
L
Q
-
S
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
P
R
-
P
S
---------
Q
---
P
S
S
L
A
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
CPG--
P
---
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
A
G
Y
Y
R
K
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
Y
M
P
Y
P
S
K
S
N
-
Q
E
V
L
E
F
V
T
S
G
-------
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
R
I
E
Y
C
---
T
Q
D
P
D
V
I
N
T
A
L
P
I
E
--------------------------------------------