@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : GRK4_HUMAN: (2015-10-08 )
MELENIVANSLLLKARQGGYGKKSGRSKKWKEILTLPPVSQCSELRHSIEKDYSSLCDKQPIGRRLFRQFCDTKPTLKRHIEFLDAVAEYEVADDEDRSDCGLSILDRFFNDKLAAPLPEIPPDVVTECRLGLKEENPSKKAFEECTRVAHNYLRGEPFEEYQESSYFSQFLQWKWLERQPVTKNTFRHYRVLGKGGFGEVCACQVRATGKMYACKKLQKKRIKKRKGEAMALNEKRILEKVQSRFVVSLAYAYETKDALCLVLTIMNGGDLKFHIYNLGNPGFDEQRAVFYAAELCCGLEDLQRERIVYRDLKPENILLDDRGHIRISDLGLATEIPEGQRVRGRVGTVGYMAPEVVNNEKYTFSPDWWGLGCLIYEMIQGHSPFKKYKEKVKWEEVDQRIKNDTEEYSEKFSEDAKSICRMLLTKNPSKRLGCRGEGAAGVKQHPVFKDINFRRLEANMLEPPFCPDPHAVYCKDVLDIEQFSVVKGIYLDTADEDFYARFATGCVSIPWQNEMIESGCFKDINKSESEEALPLDLDKNIHTPVSRPNRGFFYRLFRRGGCLTMVPSEKEVEPKQC
Atome Classification :
(82 SA)
.........10........20....---....30........40........50........---60........70-----........80........90-........100.......110....---...120.......130.......140.......150.......160.......170.......180........190.......200....---..-----.210--.........220.-...-.---..230......-.240.-...---....250.......260.......270.......280.........290.......300.....-..310.......320..----.....330....-.-..340......----..350.......-360.......370.......380.......390.......400..----.....410.......420.......430.....-..440-.......450.......460.......470.......480....--...490.......500.......510.......520.......530.......540.......550.......560.......570......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
E
L
E
N
I
V
A
N
S
L
L
L
K
ARQGGYGKKSG---R
S
K
K
W
K
E
ILTLP
P
V
S
Q
C
S
E
L
R
H
S
I
E
K
D
Y
S
S
LCDK---Q
P
I
G
R
R
L
F
R
Q
F
C-----DTK
P
T
L
K
R
H
I
E
F
L
D
A
V
A
EYE-VADDEDRSDC
G
L
S
I
L
D
R
F
FNDKLAA---PLPEI
P
P
D
V
V
T
E
C
RLGLKEENP
S
K
K
A
F
E
E
C
T
R
V
A
H
N
YLRGE
P
F
E
E
Y
Q
E
S
S
Y
F
S
Q
F
L
Q
W
K
WLERQ-PVTK
N
T
F
R
H
Y
R
V
LGKGGFG
E
V
C
A
C
Q
V
---RA-----TG----
K
M
Y
A
C
K
K
L
Q
K
K
R
I
-
K
K
R-K---GEAMAL
N
E
K
R
I
-
L
E
K
-
V
-
Q
S
R
---
F
V
V
S
L
A
Y
A
YETKD
A
L
C
L
V
L
T
IMNGG
D
L
K
F
H
I
Y
NLG--NPGF
D
E
Q
R
A
V
F
Y
A
A
E
L
CC
G
L
E
D
L
Q
R
E
R
-
I
V
Y
RDLKPE
N
I
L
LDDRG----
H
I
R
I
SDLGLATE-I-PEGQ-RVRGRV----GTVGYMA
P
E
VVN-NE
K
Y
T
FSP
D
W
W
G
L
G
C
L
I
Y
E
M
IQGHS
P
F
K
K
Y
K
E
KV
K
W
E
E
V
D
Q
R
I
KN----
D
T
E
E
Y
S
E
K
F
S
E
D
A
K
S
I
C
R
M
L
LTKNP
S
K
RLGCRG-EGAAG-VKQHPVFKDI
N
F
R
RLEANMLEPPFCPDP
H
A
V
Y
C
K
D
VL
D
I
E
Q
F
S
V
--
V
K
G
I
Y
LDTA
D
E
D
F
Y
A
R
F
ATGCVSIPW
Q
N
E
M
I
ESGCFKDINKSESEEALPLDLDKNIHTPVSRPN
R
G
F
F
Y
R
L
F
RRGG
C
L
TMVPSEKEVEPKQC
1
PsiBlast_PDB
95.68
99%
-106
- C1 -
4YHJ
1
?
A:
[25-525]
------------------------
G
---
R
S
K
K
W
K
E
I
L
T
L
P
P
V
S
Q
C
S
E
L
R
H
S
I
E
K
D
Y
S
S
L
C
D
K
---
Q
P
I
G
R
R
L
F
R
Q
F
C
-----
D
T
K
P
T
L
K
R
H
I
E
F
L
D
A
V
A
E
Y
E
-
V
A
D
D
E
D
R
S
D
C
G
L
S
I
L
D
R
F
F
N
D
K
L
A
A
---
P
L
P
E
I
P
P
D
V
V
T
E
C
R
L
G
L
K
E
E
N
P
S
K
K
A
F
E
E
C
T
R
V
A
H
N
Y
L
R
G
E
P
F
E
E
Y
Q
E
S
S
Y
F
S
Q
F
L
Q
W
K
W
L
E
R
Q
-
P
V
T
K
N
T
F
R
H
Y
R
V
L
G
K
G
G
F
G
E
V
C
A
C
Q
V
---
R
A
-----
T
G
----
K
M
Y
A
C
K
K
L
Q
K
K
R
I
-
K
K
R
-
K
---
G
E
A
M
A
L
N
E
K
R
I
-
L
E
K
-
V
-
Q
S
R
---
F
V
V
S
L
A
Y
A
Y
E
T
K
D
A
L
C
L
V
L
T
I
M
N
G
G
D
L
K
F
H
I
Y
N
L
G
--
N
P
G
F
D
E
Q
R
A
V
F
Y
A
A
E
L
C
C
G
L
E
D
L
Q
R
E
R
-
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
D
R
G
----
H
I
R
I
S
D
L
G
L
A
T
E
-
I
-
P
E
G
Q
-
R
V
R
G
R
V
----
G
T
V
G
Y
M
A
P
E
V
V
N
-
N
E
K
Y
T
F
S
P
D
W
W
G
L
G
C
L
I
Y
E
M
I
Q
G
H
S
P
F
K
K
Y
K
E
K
V
K
W
E
E
V
D
Q
R
I
K
N
----
D
T
E
E
Y
S
E
K
F
S
E
D
A
K
S
I
C
R
M
L
L
T
K
N
P
S
K
R
L
G
C
R
G
-
E
G
A
A
G
-
V
K
Q
H
P
V
F
K
D
I
N
F
R
R
L
E
A
N
M
L
E
P
P
F
C
P
D
P
H
A
V
Y
C
K
D
V
L
D
I
E
Q
F
S
V
--
V
K
G
I
Y
L
D
T
A
D
E
D
F
Y
A
R
F
A
T
G
C
V
S
I
P
W
Q
N
E
M
I
E
S
G
C
F
K
D
I
-----------------------------------------------------
21
PsiBlast_CBE
95.56
99%
-107
- C1 -
4YHJ
1
?
B:
[25-527]
------------------------
G
---
R
S
K
K
W
K
E
I
L
T
L
P
P
V
S
Q
C
S
E
L
R
H
S
I
E
K
D
Y
S
S
L
C
D
K
---
Q
P
I
G
R
R
L
F
R
Q
F
C
-----
D
T
K
P
T
L
K
R
H
I
E
F
L
D
A
V
A
E
Y
E
-
V
A
D
D
E
D
R
S
D
C
G
L
S
I
L
D
R
F
F
N
D
K
L
A
A
---
P
L
P
E
I
P
P
D
V
V
T
E
C
R
L
G
L
K
E
E
N
P
S
K
K
A
F
E
E
C
T
R
V
A
H
N
Y
L
R
G
E
P
F
E
E
Y
Q
E
S
S
Y
F
S
Q
F
L
Q
W
K
W
L
E
R
Q
-
P
V
T
K
N
T
F
R
H
Y
R
V
L
G
K
G
G
F
G
E
V
C
A
C
Q
V
---
R
A
-----
T
G
----
K
M
Y
A
C
K
K
L
Q
K
K
R
I
-
K
K
R
-
K
---
G
E
A
M
A
L
N
E
K
R
I
-
L
E
K
-
V
-
Q
S
R
---
F
V
V
S
L
A
Y
A
Y
E
T
K
D
A
L
C
L
V
L
T
I
M
N
G
G
D
L
K
F
H
I
Y
N
L
G
--
N
P
G
F
D
E
Q
R
A
V
F
Y
A
A
E
L
C
C
G
L
E
D
L
Q
R
E
R
-
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
D
R
G
----
H
I
R
I
S
D
L
G
L
A
T
E
-
I
-
P
E
G
Q
-
R
V
R
G
R
V
----
G
T
V
G
Y
M
A
P
E
V
V
N
-
N
E
K
Y
T
F
S
P
D
W
W
G
L
G
C
L
I
Y
E
M
I
Q
G
H
S
P
F
K
K
Y
K
E
K
V
K
W
E
E
V
D
Q
R
I
K
N
----
D
T
E
E
Y
S
E
K
F
S
E
D
A
K
S
I
C
R
M
L
L
T
K
N
P
S
K
R
L
G
C
R
G
-
E
G
A
A
G
-
V
K
Q
H
P
V
F
K
D
I
N
F
R
R
L
E
A
N
M
L
E
P
P
F
C
P
D
P
H
A
V
Y
C
---------------
G
I
Y
L
D
T
A
D
E
D
F
Y
A
R
F
A
T
G
C
V
S
I
P
W
Q
N
E
M
I
E
S
G
C
F
K
D
I
N
K
---------------------------------------------------
107
Fugue
87.98
66%
-97
- C1 -
2ACX
1
GRK6_HUMAN
A:
[14-532]
--------------------
K
A
R
K
G
---
K
S
K
K
W
R
Q
M
L
Q
F
P
H
I
S
Q
C
E
E
L
R
L
S
L
E
R
D
Y
H
S
L
C
E
R
---
N
P
I
G
R
L
L
F
R
E
F
C
-----
A
T
R
P
E
L
S
R
C
V
A
F
L
D
G
V
A
E
Y
E
-
V
T
P
D
D
K
R
K
A
C
G
R
N
L
T
Q
N
F
L
S
H
T
G
P
D
---
L
I
P
E
V
P
R
Q
L
V
T
N
C
T
Q
R
L
E
Q
-
G
P
C
K
D
L
F
Q
E
L
T
R
L
T
H
E
Y
L
S
V
A
P
F
A
D
Y
L
D
S
I
Y
F
N
R
F
L
Q
W
K
W
L
E
R
Q
-
P
V
T
K
N
T
F
R
Q
Y
R
V
L
G
K
G
G
F
G
E
V
C
A
C
Q
V
---
R
A
-----
T
G
----
K
M
Y
A
C
K
K
L
E
K
K
R
I
-
K
K
R
-
K
---
G
E
A
M
A
L
N
E
K
Q
I
-
L
E
K
-
V
-
N
S
R
---
F
V
V
S
L
A
Y
A
Y
E
T
K
D
A
L
C
L
V
L
T
L
M
N
G
G
D
L
K
F
H
I
Y
H
M
G
--
Q
A
G
F
P
E
A
R
A
V
F
Y
A
A
E
I
C
C
G
L
E
D
L
H
R
E
R
-
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
D
H
G
----
H
I
R
I
S
D
L
G
L
A
V
H
-
V
-
P
E
G
Q
-
T
I
K
G
R
V
----
G
T
V
G
Y
M
A
P
E
V
V
K
-
N
E
R
Y
T
F
S
P
D
W
W
A
L
G
C
L
L
Y
E
M
I
A
G
Q
S
P
F
Q
Q
R
K
K
K
I
K
R
E
E
V
E
R
L
V
K
E
----
V
P
E
E
Y
S
E
R
F
S
P
Q
A
R
S
L
C
S
Q
L
L
C
K
D
P
A
E
R
L
G
C
R
G
-
G
S
A
R
E
-
V
K
E
H
P
L
F
K
K
L
N
F
K
R
L
G
A
G
M
L
E
P
P
F
K
P
D
P
-------------------
Q
A
I
Y
C
E
P
T
D
Q
D
F
Y
Q
K
F
A
T
G
S
V
P
I
P
W
Q
N
E
M
V
E
T
E
C
F
Q
E
L
N
V
F
G
L
D
G
S
---------------------------------------------
4
PsiBlast_PDB
87.84
67%
-101
- C1 -
4WNK
1
GRK5_BOVIN
A:
[24-541]
-----------------------
K
G
---
K
S
K
K
W
K
E
I
L
K
F
P
H
I
N
Q
C
E
D
L
R
R
T
I
D
R
D
Y
C
S
L
C
D
K
---
Q
P
V
G
R
L
L
F
R
Q
F
C
-----
E
T
R
P
G
L
E
S
Y
I
Q
F
L
D
S
V
A
E
Y
E
-
V
T
P
D
E
K
L
G
E
K
G
K
E
I
M
T
K
Y
L
T
P
K
S
P
V
---
F
I
T
Q
V
G
R
D
L
V
S
Q
T
E
E
K
L
L
Q
K
-
P
C
K
E
L
F
S
A
C
V
Q
S
V
H
D
Y
L
R
G
E
P
F
H
E
Y
L
D
S
M
Y
F
D
R
F
L
Q
W
K
W
L
E
R
Q
-
P
V
T
K
N
T
F
R
Q
Y
R
V
L
G
K
G
G
F
G
E
V
C
A
C
Q
V
---
R
A
-----
T
G
----
K
M
Y
A
C
K
R
L
E
K
K
R
I
-
K
K
R
-
K
---
G
E
S
M
A
L
N
E
K
Q
I
-
L
E
K
-
V
-
N
S
R
---
F
V
V
N
L
A
Y
A
Y
E
T
K
D
A
L
C
L
V
L
T
I
M
N
G
G
D
L
K
F
H
I
Y
N
M
G
--
N
P
G
F
E
E
E
R
A
L
F
Y
A
A
E
I
L
C
G
L
E
D
L
H
H
E
N
-
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
D
Y
G
----
H
I
R
I
S
D
L
G
L
A
V
K
-
I
-
P
E
G
D
-
L
I
R
G
R
V
----
G
T
V
G
Y
M
A
P
E
V
L
N
-
N
Q
R
Y
G
L
S
P
D
Y
W
G
L
G
C
L
I
Y
E
M
I
E
G
Q
S
P
F
R
G
R
K
E
K
V
K
R
E
E
V
D
R
R
V
L
E
----
T
E
E
V
Y
S
H
K
F
S
E
E
A
K
S
I
C
K
M
L
L
T
K
D
A
K
Q
R
L
G
C
Q
E
-
E
G
A
A
E
-
V
K
R
H
P
F
F
R
N
M
N
F
K
R
L
E
A
G
M
L
D
P
P
F
V
P
D
P
R
A
V
Y
---------------------
H
T
D
D
D
F
Y
S
K
F
S
T
G
S
V
P
I
P
W
Q
S
E
M
I
E
T
E
C
F
K
E
L
N
V
F
G
P
H
G
T
L
S
P
D
L
N
R
S
--
H
----------------------------------
7
PsiBlast_PDB
87.74
66%
-98
- C1 -
2ACX
1
GRK6_HUMAN
A:
[14-532]
-------------
K
A
R
-------
K
G
---
K
S
K
K
W
R
Q
M
L
Q
F
P
H
I
S
Q
C
E
E
L
R
L
S
L
E
R
D
Y
H
S
L
C
E
R
---
N
P
I
G
R
L
L
F
R
E
F
C
-----
A
T
R
P
E
L
S
R
C
V
A
F
L
D
G
V
A
E
Y
E
-
V
T
P
D
D
K
R
K
A
C
G
R
N
L
T
Q
N
F
L
S
H
T
G
P
D
---
L
I
P
E
V
P
R
Q
L
V
T
N
C
T
Q
R
L
-
E
Q
G
P
C
K
D
L
F
Q
E
L
T
R
L
T
H
E
Y
L
S
V
A
P
F
A
D
Y
L
D
S
I
Y
F
N
R
F
L
Q
W
K
W
L
E
R
Q
-
P
V
T
K
N
T
F
R
Q
Y
R
V
L
G
K
G
G
F
G
E
V
C
A
C
Q
V
---
R
A
-----
T
G
----
K
M
Y
A
C
K
K
L
E
K
K
R
I
-
K
K
R
-
K
---
G
E
A
M
A
L
N
E
K
Q
I
-
L
E
K
-
V
-
N
S
R
---
F
V
V
S
L
A
Y
A
Y
E
T
K
D
A
L
C
L
V
L
T
L
M
N
G
G
D
L
K
F
H
I
Y
H
M
G
--
Q
A
G
F
P
E
A
R
A
V
F
Y
A
A
E
I
C
C
G
L
E
D
L
H
R
E
R
-
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
D
H
G
----
H
I
R
I
S
D
L
G
L
A
V
H
-
V
-
P
E
G
Q
-
T
I
K
G
R
V
----
G
T
V
G
Y
M
A
P
E
V
V
K
-
N
E
R
Y
T
F
S
P
D
W
W
A
L
G
C
L
L
Y
E
M
I
A
G
Q
S
P
F
Q
Q
R
K
K
K
I
K
R
E
E
V
E
R
L
V
K
E
----
V
P
E
E
Y
S
E
R
F
S
P
Q
A
R
S
L
C
S
Q
L
L
C
K
D
P
A
E
R
L
G
C
R
G
-
G
S
A
R
E
-
V
K
E
H
P
L
F
K
K
L
N
F
K
R
L
G
A
G
M
L
E
P
P
F
K
P
D
P
Q
A
I
Y
C
-------------------
E
P
T
D
Q
D
F
Y
Q
K
F
A
T
G
S
V
P
I
P
W
Q
N
E
M
V
E
T
E
C
F
Q
E
L
N
V
F
G
L
D
G
S
---------------------------------------------
116
HHSearch
87.49
65%
-98
- C1 -
2ACX
1
GRK6_HUMAN
A:
[14-532]
-------------
K
A
R
-------
K
G
---
K
S
K
K
W
R
Q
M
L
Q
F
P
H
I
S
Q
C
E
E
L
R
L
S
L
E
R
D
Y
H
S
L
C
E
R
---
N
P
I
G
R
L
L
F
R
E
F
C
-----
A
T
R
P
E
L
S
R
C
V
A
F
L
D
G
V
A
E
Y
E
-
V
T
P
D
D
K
R
K
A
C
G
R
N
L
T
Q
N
F
L
S
H
T
G
P
D
---
L
I
P
E
V
P
R
Q
L
V
T
N
C
T
Q
R
L
E
Q
-
G
P
C
K
D
L
F
Q
E
L
T
R
L
T
H
E
Y
L
S
V
A
P
F
A
D
Y
L
D
S
I
Y
F
N
R
F
L
Q
W
K
W
L
E
R
Q
-
P
V
T
K
N
T
F
R
Q
Y
R
V
L
G
K
G
G
F
G
E
V
C
A
C
Q
V
---
R
A
-----
T
G
----
K
M
Y
A
C
K
K
L
E
K
K
R
I
-
K
K
R
-
K
---
G
E
A
M
A
L
N
E
K
Q
I
-
L
E
K
-
V
-
N
S
R
---
F
V
V
S
L
A
Y
A
Y
E
T
K
D
A
L
C
L
V
L
T
L
M
N
G
G
D
L
K
F
H
I
Y
H
M
G
--
Q
A
G
F
P
E
A
R
A
V
F
Y
A
A
E
I
C
C
G
L
E
D
L
H
R
E
R
-
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
D
H
G
----
H
I
R
I
S
D
L
G
L
A
V
H
-
V
-
P
E
G
Q
-
T
I
K
G
R
V
----
G
T
V
G
Y
M
A
P
E
V
V
K
-
N
E
R
Y
T
F
S
P
D
W
W
A
L
G
C
L
L
Y
E
M
I
A
G
Q
S
P
F
Q
Q
R
K
K
K
I
K
R
E
E
V
E
R
L
V
K
E
----
V
P
E
E
Y
S
E
R
F
S
P
Q
A
R
S
L
C
S
Q
L
L
C
K
D
P
A
E
R
L
G
C
R
G
-
G
S
A
R
E
-
V
K
E
H
P
L
F
K
K
L
N
F
K
R
L
G
A
G
M
L
E
P
P
F
K
P
D
P
Q
A
I
Y
C
-------------------
E
P
T
D
Q
D
F
Y
Q
K
F
A
T
G
S
V
P
I
P
W
Q
N
E
M
V
E
T
E
C
F
Q
E
L
N
V
F
G
L
D
G
S
---------------------------------------------
24
PsiBlast_CBE
87.10
66%
-98
- C1 -
2ACX
1
GRK6_HUMAN
B:
[14-535]
-------------
K
A
R
-------
K
G
---
K
S
K
K
W
R
Q
M
L
Q
F
P
H
I
S
Q
C
E
E
L
R
L
S
L
E
R
D
Y
H
S
L
C
E
R
---
N
P
I
G
R
L
L
F
R
E
F
C
-----
A
T
R
P
E
L
S
R
C
V
A
F
L
D
G
V
A
E
Y
E
-
V
T
P
D
D
K
R
K
A
C
G
R
N
L
T
Q
N
F
L
S
H
T
G
P
D
---
L
I
P
E
V
P
R
Q
L
V
T
N
C
T
Q
R
L
-
E
Q
G
P
C
K
D
L
F
Q
E
L
T
R
L
T
H
E
Y
L
S
V
A
P
F
A
D
Y
L
D
S
I
Y
F
N
R
F
L
Q
W
K
W
L
E
R
Q
-
P
V
T
K
N
T
F
R
Q
Y
R
V
L
G
K
G
G
F
G
E
V
C
A
C
Q
V
---
R
A
-----
T
G
----
K
M
Y
A
C
K
K
L
E
K
K
R
I
-
K
K
R
-
K
---
G
E
A
M
A
L
N
E
K
Q
I
-
L
E
K
-
V
-
N
S
R
---
F
V
V
S
L
A
Y
A
Y
E
T
K
D
A
L
C
L
V
L
T
L
M
N
G
G
D
L
K
F
H
I
Y
H
M
----
A
G
F
P
E
A
R
A
V
F
Y
A
A
E
I
C
C
G
L
E
D
L
H
R
E
R
-
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
D
H
G
----
H
I
R
I
S
D
L
G
L
A
V
H
-
V
-
P
E
G
Q
-
T
I
K
G
R
V
----
G
T
V
G
Y
M
A
P
E
V
V
K
-
N
E
R
Y
T
F
S
P
D
W
W
A
L
G
C
L
L
Y
E
M
I
A
G
Q
S
P
F
Q
Q
---
K
I
K
R
E
E
V
E
R
L
V
K
E
----
V
P
E
E
Y
S
E
R
F
S
P
Q
A
R
S
L
C
S
Q
L
L
C
K
D
P
A
E
R
L
G
C
R
G
-
G
S
A
R
E
-
V
K
E
H
P
L
F
K
K
L
N
F
K
R
L
G
A
G
M
L
E
P
P
F
K
P
D
P
Q
A
I
Y
--------------------
E
P
T
D
Q
D
F
Y
Q
K
F
A
T
G
S
V
P
I
P
W
Q
N
E
M
V
E
T
E
C
F
Q
E
L
N
V
F
G
L
D
G
S
V
P
P
------------------------------------------
2
PsiBlast_PDB
86.59
67%
-90
- C1 -
4TNB
1
GRK5_HUMAN
A:
[15-543]
--------------
A
R
E
G
G
G
G
K
R
K
G
---
K
S
K
K
W
K
E
I
L
K
F
P
H
I
S
Q
C
E
D
L
R
R
T
I
D
R
D
Y
C
S
L
C
D
K
---
Q
P
I
G
R
L
L
F
R
Q
F
C
-----
E
T
R
P
G
L
E
C
Y
I
Q
F
L
D
S
V
A
E
Y
E
-
V
T
P
D
E
K
L
G
E
K
G
K
K
I
M
T
K
Y
L
T
P
K
S
P
V
---
F
I
A
Q
V
G
Q
D
L
V
S
Q
T
E
E
K
L
L
Q
K
-
P
C
K
E
L
F
S
A
C
A
Q
S
V
H
E
Y
L
R
G
E
P
F
H
E
Y
L
D
S
M
F
F
D
R
F
L
Q
W
K
W
L
E
R
Q
-
P
V
T
K
N
T
F
R
Q
Y
R
V
L
G
K
G
G
F
G
E
V
C
A
C
Q
V
---
R
A
-----
T
G
----
K
M
Y
A
C
K
R
L
E
K
K
R
I
-
K
K
R
-
K
---
G
E
S
M
A
L
N
E
K
Q
I
-
L
E
K
-
V
-
N
S
Q
---
F
V
V
N
L
A
Y
A
Y
E
T
K
D
A
L
C
L
V
L
T
I
M
N
G
G
D
L
K
F
H
I
Y
N
M
G
--
N
P
G
F
E
E
E
R
A
L
F
Y
A
A
E
I
L
C
G
L
E
D
L
H
H
E
N
-
T
V
Y
R
D
L
K
P
E
N
I
L
L
D
D
Y
G
----
H
I
R
I
S
D
L
G
L
A
V
K
-
I
-
P
E
G
D
-
L
I
R
G
R
V
----
G
T
V
G
Y
M
A
P
E
V
L
N
-
N
Q
R
Y
G
L
S
P
D
Y
W
G
L
G
C
L
I
Y
E
M
I
E
G
Q
S
P
F
R
G
R
K
E
K
V
K
R
E
E
V
D
R
R
V
L
E
----
T
E
E
V
Y
S
H
K
F
S
E
E
A
K
S
I
C
K
M
L
L
T
K
D
A
K
Q
R
L
G
C
Q
E
-
E
E
A
A
E
-
V
K
R
H
P
F
F
R
N
M
N
F
K
R
L
E
A
G
M
L
D
P
P
F
V
P
D
P
R
A
V
Y
C
K
D
V
L
D
I
E
Q
F
S
T
--
V
K
G
V
N
L
D
H
T
D
D
D
F
Y
S
K
F
S
T
G
S
V
S
I
P
W
Q
N
E
M
I
E
T
E
C
F
K
E
L
N
V
F
G
P
N
G
T
L
P
P
D
L
N
R
N
--
H
P
P
--------------------------------
3
PsiBlast_PDB
85.07
67%
-89
- C1 -
4TND
1
GRK5_HUMAN
A:
[15-543]
--------------
A
R
E
G
G
G
G
K
R
K
G
---
K
S
K
K
W
K
E
I
L
K
F
P
H
I
S
Q
C
E
D
L
R
R
T
I
D
R
D
Y
C
S
L
C
D
K
---
Q
P
I
G
R
L
L
F
R
Q
F
C
-----
E
T
R
P
G
L
E
C
Y
I
Q
F
L
D
S
V
A
E
Y
E
-
V
T
P
D
E
K
L
G
E
K
G
K
K
I
M
T
K
Y
L
T
P
K
S
P
V
---
F
I
A
Q
V
G
Q
D
L
V
S
Q
T
E
E
K
L
L
Q
K
-
P
C
K
E
L
F
S
A
C
A
Q
S
V
H
E
Y
L
R
G
E
P
F
H
E
Y
L
D
S
M
F
F
D
R
F
L
Q
W
K
W
L
E
R
Q
-
P
V
T
K
N
T
F
R
Q
Y
R
V
L
G
K
G
G
F
G
E
V
C
A
C
Q
V
---
R
A
-----
T
G
----
K
M
Y
A
C
K
R
L
E
K
K
R
I
-
K
K
R
-
K
---
G
E
S
M
A
L
N
E
K
Q
I
-
L
E
K
-
V
-
N
S
Q
---
F
V
V
N
L
A
Y
A
Y
E
T
K
D
A
L
C
L
V
L
T
I
M
N
G
G
D
L
K
F
H
I
Y
N
M
G
--
N
P
G
F
E
E
E
R
A
L
F
Y
A
A
E
I
L
C
G
L
E
D
L
H
H
E
N
-
T
V
Y
R
D
L
K
P
E
N
I
L
L
D
D
Y
G
----
H
I
R
I
S
D
L
G
L
A
V
K
-
I
-
P
E
G
D
-
L
I
R
G
R
V
----
G
T
V
G
Y
M
A
P
E
V
L
N
-
N
Q
R
Y
G
L
S
P
D
Y
W
G
L
G
C
L
I
Y
E
M
I
E
G
Q
S
P
F
R
G
R
K
E
K
V
K
R
E
E
V
D
R
R
V
L
E
----
T
E
E
V
Y
S
H
K
F
S
E
E
A
K
S
I
C
K
M
L
L
T
K
D
A
K
Q
R
L
G
C
Q
E
-
E
E
A
A
E
-
V
K
R
H
P
F
F
R
N
M
N
F
K
R
L
E
A
G
M
L
D
P
P
F
V
P
D
P
R
A
V
Y
C
K
D
V
L
D
I
E
Q
F
S
T
--
V
K
G
V
N
L
D
H
T
D
D
D
F
Y
S
K
F
S
T
G
S
V
S
I
P
W
Q
N
E
M
I
E
T
E
C
F
K
E
L
N
V
F
G
P
N
G
T
L
P
P
D
L
N
R
N
--
H
P
P
--------------------------------
106
Fugue
80.69
47%
-96
- C1 -
3C4Z
1
RK_BOVIN
A:
[31-533]
----------------------------
R
D
R
K
Y
L
A
R
L
K
L
P
P
L
S
K
C
E
A
L
R
E
S
L
D
L
G
F
E
G
M
C
L
E
---
Q
P
I
G
K
R
L
F
Q
Q
F
L
-----
R
T
H
E
Q
H
G
P
A
L
Q
L
W
K
D
I
E
D
Y
D
-
T
A
D
D
A
L
R
P
Q
K
A
Q
A
L
R
A
A
Y
L
E
P
Q
A
Q
L
---
F
C
S
F
L
D
A
E
T
V
A
R
A
R
--------
A
G
G
L
F
Q
P
L
L
R
A
V
L
A
H
L
G
Q
A
P
F
Q
E
F
L
D
S
L
Y
F
L
R
F
L
Q
W
K
W
L
E
A
Q
-
P
M
G
E
D
W
F
L
D
F
R
V
L
G
R
G
G
F
G
E
V
F
A
C
Q
M
---
K
A
-----
T
G
----
K
L
Y
A
C
K
K
L
N
K
K
R
L
-
K
K
R
-
K
---
G
Y
Q
G
A
M
V
E
K
K
I
-
L
A
K
-
V
-
H
S
R
---
F
I
V
S
L
A
Y
A
F
E
T
K
T
D
L
C
L
V
M
T
I
M
N
G
G
D
I
R
Y
H
I
Y
N
V
D
ED
N
P
G
F
Q
E
P
R
A
I
F
Y
T
A
Q
I
V
S
G
L
E
H
L
H
Q
R
N
-
I
I
Y
R
D
L
K
P
E
N
V
L
L
D
D
D
G
----
N
V
R
I
S
D
L
G
L
A
V
E
-
L
-
K
A
G
Q
T
K
T
K
G
Y
A
----
G
T
P
G
F
M
A
P
E
L
L
L
-
G
E
E
Y
D
F
S
V
D
Y
F
A
L
G
V
T
L
Y
E
M
I
A
A
R
G
P
F
R
A
R
G
E
K
V
E
N
K
E
L
K
Q
R
V
L
E
----
Q
A
V
T
Y
P
D
K
F
S
P
A
S
K
D
F
C
E
A
L
L
Q
K
D
P
E
K
R
L
G
F
R
D
-
G
S
C
D
G
-
L
R
T
H
P
L
F
R
D
I
S
W
R
Q
L
E
A
G
M
L
T
P
P
F
V
P
D
S
R
T
V
Y
A
K
N
-------
G
A
--
F
S
G
V
A
F
E
K
A
D
T
E
F
F
Q
E
F
A
S
G
T
C
P
I
P
W
Q
E
E
M
I
E
T
G
V
F
G
D
L
N
V
W
R
P
------------------------------------------------
10
PsiBlast_PDB
80.69
47%
-97
- C1 -
3C4Z
1
RK_BOVIN
A:
[31-529]
----------------------------
R
D
R
K
Y
L
A
R
L
K
L
P
P
L
S
K
C
E
A
L
R
E
S
L
D
L
G
F
E
G
M
C
L
E
---
Q
P
I
G
K
R
L
F
Q
Q
F
L
-----
R
T
H
E
Q
H
G
P
A
L
Q
L
W
K
D
I
E
D
Y
D
-
T
A
D
D
A
L
R
P
Q
K
A
Q
A
L
R
A
A
Y
L
E
P
Q
A
Q
L
---
F
C
S
F
L
D
A
E
T
V
A
R
A
R
A
G
--------
G
L
F
Q
P
L
L
R
A
V
L
A
H
L
G
Q
A
P
F
Q
E
F
L
D
S
L
Y
F
L
R
F
L
Q
W
K
W
L
E
A
Q
-
P
M
G
E
D
W
F
L
D
F
R
V
L
G
R
G
G
F
G
E
V
F
A
C
Q
M
---
K
A
-----
T
G
----
K
L
Y
A
C
K
K
L
N
K
K
R
L
-
K
K
R
-
K
---
G
Y
Q
G
A
M
V
E
K
K
I
-
L
A
K
-
V
-
H
S
R
---
F
I
V
S
L
A
Y
A
F
E
T
K
T
D
L
C
L
V
M
T
I
M
N
G
G
D
I
R
Y
H
I
Y
N
V
D
ED
N
P
G
F
Q
E
P
R
A
I
F
Y
T
A
Q
I
V
S
G
L
E
H
L
H
Q
R
N
-
I
I
Y
R
D
L
K
P
E
N
V
L
L
D
D
D
G
----
N
V
R
I
S
D
L
G
L
A
V
E
-
L
-
K
A
G
Q
T
K
T
K
G
Y
A
----
G
T
P
G
F
M
A
P
E
L
L
L
-
G
E
E
Y
D
F
S
V
D
Y
F
A
L
G
V
T
L
Y
E
M
I
A
A
R
G
P
F
R
A
R
G
E
K
V
E
N
K
E
L
K
Q
R
V
L
E
----
Q
A
V
T
Y
P
D
K
F
S
P
A
S
K
D
F
C
E
A
L
L
Q
K
D
P
E
K
R
L
G
F
R
D
-
G
S
C
D
G
-
L
R
T
H
P
L
F
R
D
I
S
W
R
Q
L
E
A
G
M
L
T
P
P
F
V
P
D
S
R
T
V
Y
A
K
N
----
G
A
F
S
-----
G
V
A
F
E
K
A
D
T
E
F
F
Q
E
F
A
S
G
T
C
P
I
P
W
Q
E
E
M
I
E
T
G
V
F
G
D
L
N
V
W
R
P
------------------------------------------------
117
HHSearch
80.52
46%
-97
- C1 -
3C4Z
1
RK_BOVIN
A:
[31-533]
----------------------------
R
D
R
K
Y
L
A
R
L
K
L
P
P
L
S
K
C
E
A
L
R
E
S
L
D
L
G
F
E
G
M
C
L
E
---
Q
P
I
G
K
R
L
F
Q
Q
F
L
-----
R
T
H
E
Q
H
G
P
A
L
Q
L
W
K
D
I
E
D
Y
D
-
T
A
D
D
A
L
R
P
Q
K
A
Q
A
L
R
A
A
Y
L
E
P
Q
A
Q
L
---
F
C
S
F
L
D
A
E
T
V
A
R
A
R
A
-----
G
---
G
L
F
Q
P
L
L
R
A
V
L
A
H
L
G
Q
A
P
F
Q
E
F
L
D
S
L
Y
F
L
R
F
L
Q
W
K
W
L
E
A
Q
-
P
M
G
E
D
W
F
L
D
F
R
V
L
G
R
G
G
F
G
E
V
F
A
C
Q
M
---
K
A
-----
T
G
----
K
L
Y
A
C
K
K
L
N
K
K
R
L
-
K
K
R
-
K
---
G
Y
Q
G
A
M
V
E
K
K
I
-
L
A
K
-
V
-
H
S
R
---
F
I
V
S
L
A
Y
A
F
E
T
K
T
D
L
C
L
V
M
T
I
M
N
G
G
D
I
R
Y
H
I
Y
N
V
D
ED
N
P
G
F
Q
E
P
R
A
I
F
Y
T
A
Q
I
V
S
G
L
E
H
L
H
Q
R
N
-
I
I
Y
R
D
L
K
P
E
N
V
L
L
D
D
D
G
----
N
V
R
I
S
D
L
G
L
A
V
E
-
L
K
A
G
Q
T
-
K
T
K
G
Y
A
----
G
T
P
G
F
M
A
P
E
L
L
L
-
G
E
E
Y
D
F
S
V
D
Y
F
A
L
G
V
T
L
Y
E
M
I
A
A
R
G
P
F
R
A
R
G
E
K
V
E
N
K
E
L
K
Q
R
V
L
E
----
Q
A
V
T
Y
P
D
K
F
S
P
A
S
K
D
F
C
E
A
L
L
Q
K
D
P
E
K
R
L
G
F
R
D
-
G
S
C
D
G
-
L
R
T
H
P
L
F
R
D
I
S
W
R
Q
L
E
A
G
M
L
T
P
P
F
V
P
D
S
R
T
V
Y
A
K
N
----
G
A
F
S
-----
G
V
A
F
E
K
A
D
T
E
F
F
Q
E
F
A
S
G
T
C
P
I
P
W
Q
E
E
M
I
E
T
G
V
F
G
D
L
N
V
W
R
P
------------------------------------------------
28
PsiBlast_CBE
80.41
47%
-98
- C1 -
3C50
1
RK_BOVIN
B:
[30-529]
-------------------------S--
R
D
R
K
Y
L
A
R
L
K
L
P
P
L
S
K
C
E
A
L
R
E
S
L
D
L
G
F
E
G
M
C
L
E
---
Q
P
I
G
K
R
L
F
Q
Q
F
L
-----
R
T
H
E
Q
H
G
P
A
L
Q
L
W
K
D
I
E
D
Y
D
-
T
A
D
D
A
L
R
P
Q
K
A
Q
A
L
R
A
A
Y
L
E
P
Q
A
Q
L
---
F
C
S
F
L
D
A
E
T
V
A
R
A
R
A
G
A
G
D
-----
G
L
F
Q
P
L
L
R
A
V
L
A
H
L
G
Q
A
P
F
Q
E
F
L
D
S
L
Y
F
L
R
F
L
Q
W
K
W
L
E
A
Q
-
P
M
G
E
D
W
F
L
D
F
R
V
L
G
R
G
G
F
G
E
V
F
A
C
Q
M
---
K
A
-----
T
G
----
K
L
Y
A
C
K
K
L
N
K
K
R
L
-
K
K
R
-
K
---
G
Y
Q
G
A
M
V
E
K
K
I
-
L
A
K
-
V
-
H
S
R
---
F
I
V
S
L
A
Y
A
F
E
T
K
T
D
L
C
L
V
M
T
I
M
N
G
G
D
I
R
Y
H
I
Y
N
V
D
ED
N
P
G
F
Q
E
P
R
A
I
F
Y
T
A
Q
I
V
S
G
L
E
H
L
H
Q
R
N
-
I
I
Y
R
D
L
K
P
E
N
V
L
L
D
D
D
G
----
N
V
R
I
S
D
L
G
L
A
V
E
-
L
-
K
A
G
Q
T
K
T
K
G
Y
A
----
G
T
P
G
F
M
A
P
E
L
L
L
-
G
E
E
Y
D
F
S
V
D
Y
F
A
L
G
V
T
L
Y
E
M
I
A
A
R
G
P
F
R
A
R
G
E
K
V
E
N
K
E
L
K
Q
R
V
L
E
----
Q
A
V
T
Y
P
D
K
F
S
P
A
S
K
D
F
C
E
A
L
L
Q
K
D
P
E
K
R
L
G
F
R
D
-
G
S
C
D
G
-
L
R
T
H
P
L
F
R
D
I
S
W
R
Q
L
E
A
G
M
L
T
P
P
F
V
P
D
S
R
T
V
Y
A
--------
F
S
T
--
V
K
G
V
A
F
E
K
A
D
T
E
F
F
Q
E
F
A
S
G
T
C
P
I
P
W
Q
E
E
M
I
E
T
G
V
F
G
D
L
N
V
W
R
P
------------------------------------------------
14
PsiBlast_PDB
80.41
47%
-97
- C1 -
4L9I
2
RK_BOVIN
A:
[2-500]
----------------------------
R
D
R
K
Y
L
A
R
L
K
L
P
P
L
S
K
C
E
A
L
R
E
S
L
D
L
G
F
E
G
M
C
L
E
---
Q
P
I
G
K
R
L
F
Q
Q
F
L
-----
R
T
H
E
Q
H
G
P
A
L
Q
L
W
K
D
I
E
D
Y
D
-
T
A
D
D
A
L
R
P
Q
K
A
Q
A
L
R
A
A
Y
L
E
P
Q
A
Q
L
---
F
C
S
F
L
D
A
E
T
V
A
R
A
R
A
G
A
G
D
-----
G
L
F
Q
P
L
L
R
A
V
L
A
H
L
G
Q
A
P
F
Q
E
F
L
D
S
L
Y
F
L
R
F
L
Q
W
K
W
L
E
A
Q
-
P
M
G
E
D
W
F
L
D
F
R
V
L
G
R
G
G
F
G
E
V
F
A
C
Q
M
---
K
A
-----
T
G
----
K
L
Y
A
C
K
K
L
N
K
K
R
L
-
K
K
R
-
K
---
G
Y
Q
G
A
M
V
E
K
K
I
-
L
A
K
-
V
-
H
S
R
---
F
I
V
S
L
A
Y
A
F
E
T
K
T
D
L
C
L
V
M
T
I
M
N
G
G
D
I
R
Y
H
I
Y
N
V
D
ED
N
P
G
F
Q
E
P
R
A
I
F
Y
T
A
Q
I
V
S
G
L
E
H
L
H
Q
R
N
-
I
I
Y
R
D
L
K
P
E
N
V
L
L
D
D
D
G
----
N
V
R
I
S
D
L
G
L
A
V
E
-
L
-
K
A
G
Q
T
K
T
K
G
Y
A
----
G
T
P
G
F
M
A
P
E
L
L
L
-
G
E
E
Y
D
F
S
V
D
Y
F
A
L
G
V
T
L
Y
E
M
I
A
A
R
G
P
F
R
A
R
G
E
K
V
E
N
K
E
L
K
Q
R
V
L
E
----
Q
A
V
T
Y
P
D
K
F
S
P
A
S
K
D
F
C
E
A
L
L
Q
K
D
P
E
K
R
L
G
F
R
D
-
G
S
C
D
G
-
L
R
T
H
P
L
F
R
D
I
S
W
R
Q
L
E
A
G
M
L
T
P
P
F
V
P
D
S
R
T
V
Y
A
K
N
I
Q
D
V
G
A
F
S
T
--
V
K
G
V
A
F
E
K
A
D
T
E
F
F
Q
E
F
A
S
G
T
C
P
I
P
W
Q
E
E
M
I
E
T
G
V
F
G
D
L
N
V
W
R
P
------------------------------------------------
29
PsiBlast_CBE
80.25
47%
-100
- C1 -
3C4X
1
RK_BOVIN
B:
[31-529]
----------------------------
R
D
R
K
Y
L
A
R
L
K
L
P
P
L
S
K
C
E
A
L
R
E
S
L
D
L
G
F
E
G
M
C
L
E
---
Q
P
I
G
K
R
L
F
Q
Q
F
L
-----
R
T
H
E
Q
H
G
P
A
L
Q
L
W
K
D
I
E
D
Y
D
-
T
A
D
D
A
L
R
P
Q
K
A
Q
A
L
R
A
A
Y
L
E
P
Q
A
Q
L
---
F
C
S
F
L
D
A
E
T
V
A
R
A
-------------
F
Q
P
L
L
R
A
V
L
A
H
L
G
Q
A
P
F
Q
E
F
L
D
S
L
Y
F
L
R
F
L
Q
W
K
W
L
E
A
Q
-
P
M
G
E
D
W
F
L
D
F
R
V
L
G
R
G
G
F
G
E
V
F
A
C
Q
M
---
K
A
-----
T
G
----
K
L
Y
A
C
K
K
L
N
K
K
R
L
-
K
K
R
-
K
---
G
Y
Q
G
A
M
V
E
K
K
I
-
L
A
K
-
V
-
H
S
R
---
F
I
V
S
L
A
Y
A
F
E
T
K
T
D
L
C
L
V
M
T
I
M
N
G
G
D
I
R
Y
H
I
Y
N
V
D
ED
N
P
G
F
Q
E
P
R
A
I
F
Y
T
A
Q
I
V
S
G
L
E
H
L
H
Q
R
N
-
I
I
Y
R
D
L
K
P
E
N
V
L
L
D
D
D
G
----
N
V
R
I
S
D
L
G
L
A
V
E
-
L
-
K
A
G
Q
T
K
T
K
G
Y
A
----
G
T
P
G
F
M
A
P
E
L
L
L
-
G
E
E
Y
D
F
S
V
D
Y
F
A
L
G
V
T
L
Y
E
M
I
A
A
R
G
P
F
R
A
R
G
E
K
V
E
N
K
E
L
K
Q
R
V
L
E
----
Q
A
V
T
Y
P
D
K
F
S
P
A
S
K
D
F
C
E
A
L
L
Q
K
D
P
E
K
R
L
G
F
R
D
-
G
S
C
D
G
-
L
R
T
H
P
L
F
R
D
I
S
W
R
Q
L
E
A
G
M
L
T
P
P
F
V
P
D
S
R
T
----------------------
E
K
A
D
T
E
F
F
Q
E
F
A
S
G
T
C
P
I
P
W
Q
E
E
M
I
E
T
G
V
F
G
D
L
N
V
W
R
P
------------------------------------------------
12
PsiBlast_PDB
79.83
47%
-97
- C1 -
3C4W
1
RK_BOVIN
A:
[31-529]
----------------------------
R
D
R
K
Y
L
A
R
L
K
L
P
P
L
S
K
C
E
A
L
R
E
S
L
D
L
G
F
E
G
M
C
L
E
---
Q
P
I
G
K
R
L
F
Q
Q
F
L
-----
R
T
H
E
Q
H
G
P
A
L
Q
L
W
K
D
I
E
D
Y
D
-
T
A
D
D
A
L
R
P
Q
K
A
Q
A
L
R
A
A
Y
L
E
P
Q
A
Q
L
---
F
C
S
F
L
D
A
E
T
V
A
R
A
R
A
G
A
G
D
-----
G
L
F
Q
P
L
L
R
A
V
L
A
H
L
G
Q
A
P
F
Q
E
F
L
D
S
L
Y
F
L
R
F
L
Q
W
K
W
L
E
A
Q
-
P
M
G
E
D
W
F
L
D
F
R
V
L
G
R
G
G
F
G
E
V
F
A
C
Q
M
---
K
A
-----
T
G
----
K
L
Y
A
C
K
K
L
N
K
K
R
L
-
K
K
R
-
K
---
G
Y
Q
G
A
M
V
E
K
K
I
-
L
A
K
-
V
-
H
S
R
---
F
I
V
S
L
A
Y
A
F
E
T
K
T
D
L
C
L
V
M
T
I
M
N
G
G
D
I
R
Y
H
I
Y
N
V
D
ED
N
P
G
F
Q
E
P
R
A
I
F
Y
T
A
Q
I
V
S
G
L
E
H
L
H
Q
R
N
-
I
I
Y
R
D
L
K
P
E
N
V
L
L
D
D
D
G
----
N
V
R
I
S
D
L
G
L
A
V
E
-
L
-
K
A
G
Q
T
K
T
K
G
Y
A
----
G
T
P
G
F
M
A
P
E
L
L
L
-
G
E
E
Y
D
F
S
V
D
Y
F
A
L
G
V
T
L
Y
E
M
I
A
A
R
G
P
F
R
A
R
G
E
K
V
E
N
K
E
L
K
Q
R
V
L
E
----
Q
A
V
T
Y
P
D
K
F
S
P
A
S
K
D
F
C
E
A
L
L
Q
K
D
P
E
K
R
L
G
F
R
D
-
G
S
C
D
G
-
L
R
T
H
P
L
F
R
D
I
S
W
R
Q
L
E
A
G
M
L
T
P
P
F
V
P
D
---------
Q
D
V
G
A
F
S
T
--
V
K
G
V
A
F
E
K
A
D
T
E
F
F
Q
E
F
A
S
G
T
C
P
I
P
W
Q
E
E
M
I
E
T
G
V
F
G
D
L
N
V
W
R
P
------------------------------------------------
30
PsiBlast_CBE
79.82
47%
-95
- C1 -
3C4W
1
RK_BOVIN
B:
[9-529]
-----
V
V
A
N
S
A
F
I
A
A
R
-
G
S
F
D
A
S
S
G
PAS
R
D
R
K
Y
L
A
R
L
K
L
P
P
L
S
K
C
E
A
L
R
E
S
L
D
L
G
F
E
G
M
C
L
E
---
Q
P
I
G
K
R
L
F
Q
Q
F
L
-----
R
T
H
E
Q
H
G
P
A
L
Q
L
W
K
D
I
E
D
Y
D
-
T
A
D
D
A
L
R
P
Q
K
A
Q
A
L
R
A
A
Y
L
E
P
Q
A
Q
L
---
F
C
S
F
L
D
A
E
T
V
A
R
A
R
A
--
G
D
-----
G
L
F
Q
P
L
L
R
A
V
L
A
H
L
G
Q
A
P
F
Q
E
F
L
D
S
L
Y
F
L
R
F
L
Q
W
K
W
L
E
A
Q
-
P
M
G
E
D
W
F
L
D
F
R
V
L
G
R
G
G
F
G
E
V
F
A
C
Q
M
---
K
A
-----
T
G
----
K
L
Y
A
C
K
K
L
N
K
K
R
L
-
K
K
R
-
K
---
G
Y
Q
G
A
M
V
E
K
K
I
-
L
A
K
-
V
-
H
S
R
---
F
I
V
S
L
A
Y
A
F
E
T
K
T
D
L
C
L
V
M
T
I
M
N
G
G
D
I
R
Y
H
I
Y
N
V
D
ED
N
P
G
F
Q
E
P
R
A
I
F
Y
T
A
Q
I
V
S
G
L
E
H
L
H
Q
R
N
-
I
I
Y
R
D
L
K
P
E
N
V
L
L
D
D
D
G
----
N
V
R
I
S
D
L
G
L
A
V
E
-
L
-
K
A
G
Q
T
K
T
K
G
Y
A
----
G
T
P
G
F
M
A
P
E
L
L
L
-
G
E
E
Y
D
F
S
V
D
Y
F
A
L
G
V
T
L
Y
E
M
I
A
A
R
G
P
F
R
A
R
G
E
K
V
E
N
K
E
L
K
Q
R
V
L
E
----
Q
A
V
T
Y
P
D
K
F
S
P
A
S
K
D
F
C
E
A
L
L
Q
K
D
P
E
K
R
L
G
F
R
D
-
G
S
C
D
G
-
L
R
T
H
P
L
F
R
D
I
S
W
R
Q
L
E
A
G
M
L
T
P
P
F
V
P
D
S
R
T
V
Y
A
K
N
--------
T
--
V
K
G
V
A
F
E
K
A
D
T
E
F
F
Q
E
F
A
S
G
T
C
P
I
P
W
Q
E
E
M
I
E
T
G
V
F
G
D
L
N
V
W
R
P
------------------------------------------------
8
PsiBlast_PDB
79.28
47%
-94
- C1 -
3C4X
1
RK_BOVIN
A:
[30-529]
-------------------------S--
R
D
R
K
Y
L
A
R
L
K
L
P
P
L
S
K
C
E
A
L
R
E
S
L
D
L
G
F
E
G
M
C
L
E
---
Q
P
I
G
K
R
L
F
Q
Q
F
L
-----
R
T
H
E
Q
H
G
P
A
L
Q
L
W
K
D
I
E
D
Y
D
-
T
A
D
D
A
L
R
P
Q
K
A
Q
A
L
R
A
A
Y
L
E
P
Q
A
Q
L
---
F
C
S
F
L
D
A
E
T
V
A
R
A
R
A
G
A
G
D
-----
G
L
F
Q
P
L
L
R
A
V
L
A
H
L
G
Q
A
P
F
Q
E
F
L
D
S
L
Y
F
L
R
F
L
Q
W
K
W
L
E
A
Q
-
P
M
G
E
D
W
F
L
D
F
R
V
L
G
R
G
G
F
G
E
V
F
A
C
Q
M
---
K
A
-----
T
G
----
K
L
Y
A
C
K
K
L
N
K
K
R
L
-
K
K
R
-
K
---
G
Y
Q
G
A
M
V
E
K
K
I
-
L
A
K
-
V
-
H
S
R
---
F
I
V
S
L
A
Y
A
F
E
T
K
T
D
L
C
L
V
M
T
I
M
N
G
G
D
I
R
Y
H
I
Y
N
V
D
ED
N
P
G
F
Q
E
P
R
A
I
F
Y
T
A
Q
I
V
S
G
L
E
H
L
H
Q
R
N
-
I
I
Y
R
D
L
K
P
E
N
V
L
L
D
D
D
G
----
N
V
R
I
S
D
L
G
L
A
V
E
-
L
-
K
A
G
Q
T
K
T
K
G
Y
A
----
G
T
P
G
F
M
A
P
E
L
L
L
-
G
E
E
Y
D
F
S
V
D
Y
F
A
L
G
V
T
L
Y
E
M
I
A
A
R
G
P
F
R
A
R
G
E
K
V
E
N
K
E
L
K
Q
R
V
L
E
----
Q
A
V
T
Y
P
D
K
F
S
P
A
S
K
D
F
C
E
A
L
L
Q
K
D
P
E
K
R
L
G
F
R
D
-
G
S
C
D
G
-
L
R
T
H
P
L
F
R
D
I
S
W
R
Q
L
E
A
G
M
L
T
P
P
F
V
P
D
--------
I
Q
D
V
G
A
F
S
T
--
V
K
G
V
A
F
E
K
A
D
T
E
F
F
Q
E
F
A
S
G
T
C
P
I
P
W
Q
E
E
M
I
E
T
G
V
F
G
D
L
N
V
W
R
P
------------------------------------------------
11
PsiBlast_PDB
78.44
47%
-95
- C1 -
3C51
1
RK_BOVIN
A:
[31-529]
----------------------------
R
D
R
K
Y
L
A
R
L
K
L
P
P
L
S
K
C
E
A
L
R
E
S
L
D
L
G
F
E
G
M
C
L
E
---
Q
P
I
G
K
R
L
F
Q
Q
F
L
-----
R
T
H
E
Q
H
G
P
A
L
Q
L
W
K
D
I
E
D
Y
D
-
T
A
D
D
A
L
R
P
Q
K
A
Q
A
L
R
A
A
Y
L
E
P
Q
A
Q
L
---
F
C
S
F
L
D
A
E
T
V
A
R
A
R
A
G
--------
G
L
F
Q
P
L
L
R
A
V
L
A
H
L
G
Q
A
P
F
Q
E
F
L
D
S
L
Y
F
L
R
F
L
Q
W
K
W
L
E
A
Q
-
P
M
G
E
D
W
F
L
D
F
R
V
L
G
R
G
G
F
G
E
V
F
A
C
Q
M
---
K
A
-----
T
G
----
K
L
Y
A
C
K
K
L
N
K
K
R
L
-
K
K
R
-
K
---
G
Y
Q
G
A
M
V
E
K
K
I
-
L
A
K
-
V
-
H
S
R
---
F
I
V
S
L
A
Y
A
F
E
T
K
T
D
L
C
L
V
M
T
I
M
N
G
G
D
I
R
Y
H
I
Y
N
V
D
ED
N
P
G
F
Q
E
P
R
A
I
F
Y
T
A
Q
I
V
S
G
L
E
H
L
H
Q
R
N
-
I
I
Y
R
D
L
K
P
E
N
V
L
L
D
D
D
G
----
N
V
R
I
S
D
L
G
L
A
V
E
-
L
-
K
A
G
Q
T
K
T
K
G
Y
A
----
G
T
P
G
F
M
A
P
E
L
L
L
-
G
E
E
Y
D
F
S
V
D
Y
F
A
L
G
V
T
L
Y
E
M
I
A
A
R
G
P
F
R
A
R
G
E
K
V
E
N
K
E
L
K
Q
R
V
L
E
----
Q
A
V
T
Y
P
D
K
F
S
P
A
S
K
D
F
C
E
A
L
L
Q
K
D
P
E
K
R
L
G
F
R
D
-
G
S
C
D
G
-
L
R
T
H
P
L
F
R
D
I
S
W
R
Q
L
E
A
G
M
L
T
P
P
F
V
P
D
S
R
-------------
S
T
--
V
K
G
V
A
F
E
K
A
D
T
E
F
F
Q
E
F
A
S
G
T
C
P
I
P
W
Q
E
E
M
I
E
T
G
V
F
G
D
L
N
V
W
R
P
------------------------------------------------
35
PsiBlast_CBE
70.19
36%
-94
- C1 -
3PVU
1
ARBK1_BOVIN
A:
[30-530]
-------------------------------
K
---
K
I
L
L
P
E
P
S
I
R
S
V
M
Q
K
Y
L
E
D
R
G
E
V
T
F
E
K
I
F
S
Q
K
L
G
Y
L
L
F
R
D
F
C
L
KHLE
E
A
K
P
L
----
V
E
F
Y
E
E
I
K
K
Y
E
K
L
E
T
E
E
E
R
L
V
C
S
R
E
I
F
D
T
Y
I
M
K
E
L
L
A
---
C
S
H
P
F
S
K
S
A
I
E
H
V
Q
G
H
L
V
K
K
Q
V
P
P
D
L
F
Q
P
Y
I
E
E
I
C
Q
N
L
R
G
D
V
F
Q
K
F
I
E
S
D
K
F
T
R
F
C
Q
W
K
N
V
E
L
N
I
H
L
T
M
N
D
F
S
V
H
R
I
I
G
R
G
G
F
G
E
V
Y
G
C
R
K
---
A
D
-----
T
G
----
K
M
Y
A
M
K
C
L
D
K
K
R
I
-
K
M
K
-
Q
---
G
E
T
L
A
L
N
E
R
I
M
-
L
S
L
-
V
-
S
T
G
DCP
F
I
V
C
M
S
Y
A
F
H
T
P
D
K
L
S
F
I
L
D
L
M
N
G
G
D
L
H
Y
H
L
S
Q
H
G
--
V
--
F
S
E
A
D
M
R
F
Y
A
A
E
I
I
L
G
L
E
H
M
H
N
R
F
-
V
V
Y
R
D
L
K
P
A
N
I
L
L
D
E
H
G
----
H
V
R
I
S
D
L
G
L
A
C
D
-
F
-
S
K
-
K
-
K
P
H
A
S
V
----
G
T
H
G
Y
M
A
P
E
V
L
Q
K
G
V
A
Y
D
S
S
A
D
W
F
S
L
G
C
M
L
F
K
L
L
R
G
H
S
P
F
R
Q
H
K
T
K
D
K
-
H
E
I
D
R
M
T
L
T
----
M
A
V
E
L
P
D
S
F
S
P
E
L
R
S
L
L
E
G
L
L
Q
R
D
V
N
R
R
L
G
C
L
G
-
R
G
A
Q
E
-
V
K
E
S
P
F
F
R
S
L
D
W
Q
M
V
F
L
Q
K
Y
P
P
P
L
I
P
P
R
G
------------------------
D
S
D
Q
E
L
Y
R
N
F
P
L
-
T
I
S
E
R
W
Q
Q
E
V
A
E
T
-
V
F
D
T
I
N
A
E
T
D
R
L
E
A
R
K
K
T
K
N
K
Q
L
G
H
E
E
D
Y
A
L
G
K
D
C
I
M
H
G
Y
M
S
K
M
G
W
Q
R
R
Y
F
Y
L
F
P
N
R
L
34
PsiBlast_CBE
69.71
36%
-89
- C1 -
3PVW
1
ARBK1_BOVIN
A:
[29-530]
------------------------------
S
K
---
K
I
L
L
P
E
P
S
I
R
S
V
M
Q
K
Y
L
E
D
R
G
E
V
T
F
E
K
I
F
S
Q
K
L
G
Y
L
L
F
R
D
F
C
L
KHLE
E
A
K
P
L
----
V
E
F
Y
E
E
I
K
K
Y
E
K
L
E
T
E
E
E
R
L
V
C
S
R
E
I
F
D
T
Y
I
M
K
E
L
L
A
---
C
S
H
P
F
S
K
S
A
I
E
H
V
Q
G
H
L
V
K
K
Q
V
P
P
D
L
F
Q
P
Y
I
E
E
I
C
Q
N
L
R
G
D
V
F
Q
K
F
I
E
S
D
K
F
T
R
F
C
Q
W
K
N
V
E
L
N
I
H
L
T
M
N
D
F
S
V
H
R
I
I
G
R
G
G
F
G
E
V
Y
G
C
R
K
---
A
D
-----
T
G
----
K
M
Y
A
M
K
C
L
D
K
K
R
I
-
K
M
K
-
Q
---
G
E
T
L
A
L
N
E
R
I
M
-
L
S
L
-
V
-
S
T
G
DCP
F
I
V
C
M
S
Y
A
F
H
T
P
D
K
L
S
F
I
L
D
L
M
N
G
G
D
L
H
Y
H
L
S
Q
H
G
--
V
--
F
S
E
A
D
M
R
F
Y
A
A
E
I
I
L
G
L
E
H
M
H
N
R
F
-
V
V
Y
R
D
L
K
P
A
N
I
L
L
D
E
H
G
----
H
V
R
I
S
D
L
G
L
A
C
D
-
F
-
S
K
-
K
-
K
P
H
A
S
V
----
G
T
H
G
Y
M
A
P
E
V
L
Q
K
G
V
A
Y
D
S
S
A
D
W
F
S
L
G
C
M
L
F
K
L
L
R
G
H
S
P
F
R
Q
H
K
T
K
D
K
-
H
E
I
D
R
M
T
L
T
----
M
A
V
E
L
P
D
S
F
S
P
E
L
R
S
L
L
E
G
L
L
Q
R
D
V
N
R
R
L
G
C
L
G
-
R
G
A
Q
E
-
V
K
E
S
P
F
F
R
S
L
D
W
Q
M
V
F
L
Q
K
Y
P
P
P
L
I
P
P
R
G
---------------------
K
L
L
D
S
D
Q
E
L
Y
R
N
F
P
L
-
T
I
S
E
R
W
Q
Q
E
V
A
E
T
-
V
F
D
T
I
N
A
E
T
D
R
L
E
A
R
K
K
T
K
N
K
Q
L
G
H
E
E
D
Y
A
L
G
K
D
C
I
M
H
G
Y
M
S
K
M
G
W
Q
R
R
Y
F
Y
L
F
P
N
R
L
39
PsiBlast_CBE
67.31
36%
-87
- C1 -
3KRW
1
ARBK1_HUMAN
A:
[29-529]
-------------------------------
K
---
K
I
L
L
P
E
P
S
I
R
S
V
M
Q
K
Y
L
E
D
R
G
E
V
T
F
E
K
I
F
S
Q
K
L
G
Y
L
L
F
R
D
F
C
L
NHLE
E
A
R
P
L
----
V
E
F
Y
E
E
I
K
K
Y
E
K
L
E
T
E
E
E
R
V
A
R
S
R
E
I
F
D
S
Y
I
M
K
E
L
L
A
H--
P
F
S
K
S
A
T
E
H
V
-
Q
G
H
L
G
K
K
Q
V
P
P
D
--
L
F
Q
P
Y
I
E
E
I
C
Q
N
L
R
G
D
V
F
Q
K
F
I
E
S
D
K
F
T
R
F
C
Q
W
K
N
V
E
L
N
I
H
L
T
M
N
D
F
S
V
H
R
I
I
G
R
G
G
F
G
E
V
Y
G
C
R
K
---
A
D
-----
T
G
----
K
M
Y
A
M
K
C
L
D
K
K
R
I
-
K
M
K
-
Q
---
G
E
T
L
A
L
N
E
R
I
M
-
L
S
L
-
V
-
S
T
G
DCP
F
I
V
C
M
S
Y
A
F
H
T
P
D
K
L
S
F
I
L
D
L
M
N
G
G
D
L
H
Y
H
L
S
Q
H
G
--
V
--
F
S
E
A
D
M
R
F
Y
A
A
E
I
I
L
G
L
E
H
M
H
N
R
F
-
V
V
Y
R
D
L
K
P
A
N
I
L
L
D
E
H
G
----
H
V
R
I
S
D
L
G
L
A
C
D
-
F
-
S
K
-
K
-
K
P
H
A
S
V
----
G
T
H
G
Y
M
A
P
E
V
L
Q
K
G
V
A
Y
D
S
S
A
D
W
F
S
L
G
C
M
L
F
K
L
L
R
G
H
S
P
F
R
Q
H
K
T
K
D
K
-
H
E
I
D
R
M
T
L
T
----
M
A
V
E
L
P
D
S
F
S
P
E
L
R
S
L
L
E
G
L
L
Q
R
D
V
N
R
R
L
G
C
L
G
-
R
G
A
Q
E
-
V
K
E
S
P
F
F
R
S
L
D
W
Q
M
V
F
L
Q
K
Y
P
P
P
L
I
P
P
R
---------------
E
ED
T
K
G
I
K
L
L
D
S
D
Q
E
L
Y
R
N
F
P
L
-
T
I
S
E
R
W
Q
Q
E
V
A
E
T
-
V
F
D
T
I
N
A
E
T
D
R
L
E
A
R
K
K
A
K
N
K
Q
L
G
H
E
E
D
Y
A
L
G
K
D
C
I
M
H
G
Y
M
S
K
M
W
Q
R
R
Y
F
Y
L
F
P
N
R
L
E
36
PsiBlast_CBE
66.62
36%
-92
- C1 -
4PNK
1
ARBK1_HUMAN
A:
[30-530]
-------------------------------
K
---
K
I
L
L
P
E
P
S
I
R
S
V
M
Q
K
Y
L
E
D
R
G
E
V
T
F
E
K
I
F
S
Q
K
L
G
Y
L
L
F
R
D
F
C
L
N
HLE
E
A
R
P
L
----
V
E
F
Y
E
E
I
K
K
Y
E
K
L
E
T
E
E
E
R
V
A
R
S
R
E
I
F
D
S
Y
I
M
K
E
L
L
A
CSH
P
F
S
K
S
A
T
E
H
V
-
Q
G
H
L
G
K
K
Q
V
P
P
D
--
L
F
Q
P
Y
I
E
E
I
C
Q
N
L
R
G
D
V
F
Q
K
F
I
E
S
D
K
F
T
R
F
C
Q
W
K
N
V
E
L
N
I
H
L
T
M
N
D
F
S
V
H
R
I
I
G
R
G
G
F
G
E
V
Y
G
C
R
K
---
A
D
-----
T
G
----
K
M
Y
A
M
K
C
L
D
K
K
R
I
-
K
M
K
-
Q
---
G
E
T
L
A
L
N
E
R
I
M
-
L
S
L
-
V
-
S
T
G
DCP
F
I
V
C
M
S
Y
A
F
H
T
P
D
K
L
S
F
I
L
D
L
M
N
G
G
D
L
H
Y
H
L
S
Q
H
G
--
V
--
F
S
E
A
D
M
R
F
Y
A
A
E
I
I
L
G
L
E
H
M
H
N
R
F
-
V
V
Y
R
D
L
K
P
A
N
I
L
L
D
E
H
G
----
H
V
R
I
S
D
L
G
L
A
C
D
-
F
-
S
K
-
K
-
K
P
H
A
S
V
----
G
T
H
G
Y
M
A
P
E
V
L
Q
K
G
V
A
Y
D
S
S
A
D
W
F
S
L
G
C
M
L
F
K
L
L
R
G
H
S
P
F
R
Q
H
K
T
K
D
K
-
H
E
I
D
R
M
T
L
T
----
M
A
V
E
L
P
D
S
F
S
P
E
L
R
S
L
L
E
G
L
L
Q
R
D
V
N
R
R
L
G
C
L
G
-
R
G
A
Q
E
-
V
K
E
S
P
F
F
R
S
L
D
W
Q
M
V
F
L
Q
K
Y
P
P
P
L
I
P
P
R
-
E
V
N
A
-------------
T
K
G
I
K
L
L
D
S
D
Q
E
L
Y
R
N
F
P
L
-
T
I
S
E
R
W
Q
Q
E
V
A
E
T
-
V
F
D
T
I
N
A
E
T
D
R
L
E
A
R
K
K
A
K
N
K
Q
L
G
H
E
E
D
Y
A
L
G
K
D
C
I
M
H
G
Y
M
S
K
M
G
N
P
F
L
T
Q
W
Q
R
R
Y
F
Y
38
PsiBlast_CBE
65.78
36%
-86
- C1 -
3KRX
1
ARBK1_HUMAN
A:
[29-529]
-------------------------------
K
---
K
I
L
L
P
E
P
S
I
R
S
V
M
Q
K
Y
L
E
D
R
G
E
V
T
F
E
K
I
F
S
Q
K
L
G
Y
L
L
F
R
D
F
C
L
NHLE
E
A
R
P
L
----
V
E
F
Y
E
E
I
K
K
Y
E
K
L
E
T
E
E
E
R
V
A
R
S
R
E
I
F
D
S
Y
I
M
K
E
L
L
A
H--
P
F
S
K
S
A
T
E
H
V
-
Q
G
H
L
G
K
K
Q
V
P
P
D
--
L
F
Q
P
Y
I
E
E
I
C
Q
N
L
R
G
D
V
F
Q
K
F
I
E
S
D
K
F
T
R
F
C
Q
W
K
N
V
E
L
N
I
H
L
T
M
N
D
F
S
V
H
R
I
I
G
R
G
G
F
G
E
V
Y
G
C
R
K
---
A
D
-----
T
G
----
K
M
Y
A
M
K
C
L
D
K
K
R
I
-
K
M
K
-
Q
---
G
E
T
L
A
L
N
E
R
I
M
-
L
S
L
-
V
-
S
T
G
DCP
F
I
V
C
M
S
Y
A
F
H
T
P
D
K
L
S
F
I
L
D
L
M
N
G
G
D
L
H
Y
H
L
S
Q
H
G
--
V
--
F
S
E
A
D
M
R
F
Y
A
A
E
I
I
L
G
L
E
H
M
H
N
R
F
-
V
V
Y
R
D
L
K
P
A
N
I
L
L
D
E
H
G
----
H
V
R
I
S
D
L
G
L
A
C
D
-
F
-
S
K
-
K
-
K
P
H
A
S
V
----
G
T
H
G
Y
M
A
P
E
V
L
Q
K
G
V
A
Y
D
S
S
A
D
W
F
S
L
G
C
M
L
F
K
L
L
R
G
H
S
P
F
R
Q
H
K
T
K
D
K
-
H
E
I
D
R
M
T
L
T
----
M
A
V
E
L
P
D
S
F
S
P
E
L
R
S
L
L
E
G
L
L
Q
R
D
V
N
R
R
L
G
C
L
G
-
R
G
A
Q
E
-
V
K
E
S
P
F
F
R
S
L
D
W
Q
M
V
F
L
Q
K
Y
P
P
P
L
I
P
P
R
---------------
E
ED
T
K
G
I
K
L
L
D
S
D
Q
E
L
Y
R
N
F
P
L
-
T
I
S
E
R
W
Q
Q
E
V
A
E
T
-
V
F
D
T
I
N
A
E
T
D
R
L
E
A
R
K
K
A
K
N
K
Q
L
G
H
E
E
D
Y
A
L
G
K
D
C
I
M
H
G
Y
M
S
K
M
W
Q
R
R
Y
F
Y
L
F
P
N
R
L
E
40
PsiBlast_CBE
63.30
38%
-91
- C1 -
4MK0
1
ARBK1_HUMAN
A:
[32-501]
-----------------------------------------------------------------
Q
K
L
G
Y
L
L
F
R
D
F
C
L
NHLE
E
A
R
P
L
----
V
E
F
Y
E
E
I
K
K
Y
E
K
L
E
T
E
E
E
R
V
A
R
S
R
E
I
F
D
S
Y
I
M
K
E
L
L
A
CSH
P
F
S
K
S
A
T
E
H
V
-
Q
G
H
L
G
K
K
Q
V
P
P
D
--
L
F
Q
P
Y
I
E
E
I
C
Q
N
L
R
G
D
V
F
Q
K
F
I
E
S
D
K
F
T
R
F
C
Q
W
K
N
V
E
L
N
I
H
L
T
M
N
D
F
S
V
H
R
I
I
G
R
G
G
F
G
E
V
Y
G
C
R
K
---
A
D
-----
T
G
----
K
M
Y
A
M
K
C
L
D
K
K
R
I
-
K
M
K
-
Q
---
G
E
T
L
A
L
N
E
R
I
M
-
L
S
L
-
V
-
S
T
G
DCP
F
I
V
C
M
S
Y
A
F
H
T
P
D
K
L
S
F
I
L
D
L
M
N
G
G
D
L
H
Y
H
L
S
Q
H
G
--
V
--
F
S
E
A
D
M
R
F
Y
A
A
E
I
I
L
G
L
E
H
M
H
N
R
F
-
V
V
Y
R
D
L
K
P
A
N
I
L
L
D
E
H
G
----
H
V
R
I
S
D
L
G
L
A
C
D
-
F
-
S
K
-
K
-
K
P
H
A
S
V
----
G
T
H
G
Y
M
A
P
E
V
L
Q
K
G
V
A
Y
D
S
S
A
D
W
F
S
L
G
C
M
L
F
K
L
L
R
G
H
S
P
F
R
Q
H
K
T
K
D
K
-
H
E
I
D
R
M
T
L
T
----
M
A
V
E
L
P
D
S
F
S
P
E
L
R
S
L
L
E
G
L
L
Q
R
D
V
N
R
R
L
G
C
L
G
-
R
G
A
Q
E
-
V
K
E
S
P
F
F
R
S
L
D
W
Q
M
V
F
L
Q
K
Y
P
P
P
L
I
P
P
R
G
E
V
N
A
A
D
A
F
---------
T
K
G
I
K
L
L
D
S
D
Q
E
L
Y
R
N
F
P
L
-
T
I
S
E
R
W
Q
Q
E
V
A
E
T
-
V
F
D
T
I
N
A
E
T
D
R
L
E
A
R
K
K
A
K
N
K
Q
L
G
H
E
E
D
Y
A
L
G
K
D
C
I
M
H
G
Y
M
S
K
M
G
N
P
F
L
T
Q
W
Q
R
R
Y
F
Y
66
PsiBlast_CBE
56.28
39%
-99
- C1 -
3OW4
1
AKT1_HUMAN
B:
[6-288]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
T
M
N
E
F
E
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
K
E
---
K
A
-----
T
G
----
R
Y
Y
A
M
K
I
L
K
K
E
V
I
-
V
A
K
-
D
---
E
V
A
H
T
L
T
E
N
R
V
-
L
Q
N
-
S
-
R
H
P
---
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
----
E
R
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
K
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
K
D
G
----
H
I
K
I
T
D
F
G
L
C
K
E
G
I
-
K
D
G
A
-
T
M
K
T
F
C
----
G
T
P
E
Y
L
A
P
E
V
L
E
-
D
N
D
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
Y
N
Q
D
H
----
E
K
L
F
E
L
I
L
M
----
E
E
I
R
F
P
R
T
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
R
L
G
G
G
S
-
E
D
A
K
E
-
I
M
Q
H
R
F
F
A
G
I
V
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
P
Q
V
T
S
E
T
D
T
R
Y
F
D
E
E
F
T
A
Q
--
M
I
T
R
P
H
F
P
Q
F
D
Y
S
A
S
S
----------------------------------------------------------------------------
56
PsiBlast_CBE
56.09
39%
-97
- C1 -
3MVH
1
AKT1_HUMAN
A:
[7-289]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
T
M
N
E
F
E
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
K
E
---
K
A
-----
T
G
----
R
Y
Y
A
M
K
I
L
K
K
E
V
I
-
V
A
K
-
D
---
E
V
A
H
T
L
T
E
N
R
V
-
L
Q
N
-
S
-
R
H
P
---
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
----
E
R
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
K
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
K
D
G
----
H
I
K
I
T
D
F
G
L
C
K
E
G
I
-
K
D
G
A
-
T
M
K
T
F
C
----
G
T
P
E
Y
L
A
P
E
V
L
E
-
D
N
D
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
Y
N
Q
D
H
----
E
K
L
F
E
L
I
L
M
----
E
E
I
R
F
P
R
T
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
R
L
G
G
G
S
-
E
D
A
K
E
-
I
M
Q
H
R
F
F
A
G
I
V
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
P
Q
V
T
S
E
T
D
T
R
Y
F
D
E
E
F
T
A
Q
--
R
P
H
F
P
Q
F
D
Y
S
A
---------------------------------------------------------------------------------
22
PsiBlast_CBE
55.85
66%
29
- C1 -
3NYO
2
GRK6_HUMAN
B:
[4-557]
-
E
L
E
N
I
V
A
N
T
V
L
L
K
A
R
E
G
G
G
G
N
R
K
G
---
K
S
K
K
W
R
Q
M
L
Q
F
P
H
I
S
Q
C
E
E
L
R
L
S
L
E
R
D
Y
H
S
L
C
E
R
---
Q
P
I
G
R
L
L
F
R
E
F
C
-----
A
T
R
P
E
L
S
R
C
V
A
F
L
D
G
V
A
E
Y
E
-
V
T
P
D
D
K
R
K
A
C
G
R
Q
L
T
Q
N
F
L
S
H
T
G
P
D
---
L
I
P
E
V
P
R
Q
L
V
T
N
C
T
Q
R
L
-
E
Q
G
P
C
K
D
L
F
Q
E
L
T
R
L
T
H
E
Y
L
S
V
A
P
F
A
D
Y
L
D
S
I
Y
F
N
R
F
L
Q
W
K
W
L
E
R
Q
-
P
V
T
K
N
T
F
R
Q
Y
R
V
L
G
K
G
G
F
G
E
V
C
A
C
Q
V
---
R
A
-----
T
G
----
K
M
Y
A
C
K
K
L
E
K
K
R
I
-
K
K
R
-
K
---
G
E
A
M
A
L
N
E
K
Q
I
-
L
E
K
-
V
-
N
S
R
---
F
V
V
S
L
A
Y
A
Y
E
T
K
D
A
L
C
L
V
L
T
L
M
N
G
G
D
L
K
F
H
I
Y
H
M
G
--
Q
A
G
F
P
E
A
R
A
V
F
Y
A
A
E
I
C
C
G
L
E
D
L
H
R
E
R
-
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
D
H
G
----
H
I
R
I
S
D
L
G
L
A
V
H
-
V
-
P
E
G
Q
-
T
I
K
G
R
V
----
G
T
V
G
Y
M
A
P
E
V
V
K
-
N
E
R
Y
T
F
S
P
D
W
W
A
L
G
C
L
L
Y
E
M
I
A
G
Q
S
P
F
Q
---
K
K
I
K
R
E
E
V
E
R
L
V
K
E
----
V
P
E
E
Y
S
E
R
F
S
P
Q
A
R
S
L
C
S
Q
L
L
C
K
D
P
A
E
R
L
G
C
R
G
-
G
S
A
R
E
-
V
K
E
H
P
L
F
K
K
L
N
F
K
R
L
G
A
G
M
L
E
P
P
F
K
P
D
P
Q
A
I
Y
C
K
D
V
L
D
I
E
Q
F
S
T
--
V
K
G
V
E
L
E
P
T
D
Q
D
F
Y
Q
K
F
A
T
G
S
V
P
I
P
W
Q
N
E
M
V
E
T
E
C
F
Q
E
L
N
V
F
G
L
D
G
S
V
P
P
D
L
D
W
K
G
Q
P
P
A
P
-
P
K
K
G
L
L
Q
R
L
F
S
-------------------
5
PsiBlast_PDB
55.53
66%
31
- C1 -
3NYN
2
GRK6_HUMAN
A:
[4-557]
-
E
L
E
N
I
V
A
N
T
V
L
L
K
A
R
E
G
G
G
G
N
R
K
G
---
K
S
K
K
W
R
Q
M
L
Q
F
P
H
I
S
Q
C
E
E
L
R
L
S
L
E
R
D
Y
H
S
L
C
E
R
---
Q
P
I
G
R
L
L
F
R
E
F
C
-----
A
T
R
P
E
L
S
R
C
V
A
F
L
D
G
V
A
E
Y
E
-
V
T
P
D
D
K
R
K
A
C
G
R
Q
L
T
Q
N
F
L
S
H
T
G
P
D
---
L
I
P
E
V
P
R
Q
L
V
T
N
C
T
Q
R
L
-
E
Q
G
P
C
K
D
L
F
Q
E
L
T
R
L
T
H
E
Y
L
S
V
A
P
F
A
D
Y
L
D
S
I
Y
F
N
R
F
L
Q
W
K
W
L
E
R
Q
-
P
V
T
K
N
T
F
R
Q
Y
R
V
L
G
K
G
G
F
G
E
V
C
A
C
Q
V
---
R
A
-----
T
G
----
K
M
Y
A
C
K
K
L
E
K
K
R
I
-
K
K
R
-
K
---
G
E
A
M
A
L
N
E
K
Q
I
-
L
E
K
-
V
-
N
S
R
---
F
V
V
S
L
A
Y
A
Y
E
T
K
D
A
L
C
L
V
L
T
L
M
N
G
G
D
L
K
F
H
I
Y
H
M
G
--
Q
A
G
F
P
E
A
R
A
V
F
Y
A
A
E
I
C
C
G
L
E
D
L
H
R
E
R
-
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
D
H
G
----
H
I
R
I
S
D
L
G
L
A
V
H
-
V
-
P
E
G
Q
-
T
I
K
G
R
V
----
G
T
V
G
Y
M
A
P
E
V
V
K
-
N
E
R
Y
T
F
S
P
D
W
W
A
L
G
C
L
L
Y
E
M
I
A
G
Q
S
P
F
Q
---
K
K
I
K
R
E
E
V
E
R
L
V
K
E
----
V
P
E
E
Y
S
E
R
F
S
P
Q
A
R
S
L
C
S
Q
L
L
C
K
D
P
A
E
R
L
G
C
R
G
-
G
S
A
R
E
-
V
K
E
H
P
L
F
K
K
L
N
F
K
R
L
G
A
G
M
L
E
P
P
F
K
P
D
P
Q
A
I
Y
C
K
D
V
L
D
I
E
Q
F
S
T
--
V
K
G
V
E
L
E
P
T
D
Q
D
F
Y
Q
K
F
A
T
G
S
V
P
I
P
W
Q
N
E
M
V
E
T
E
C
F
Q
E
L
N
V
F
G
L
D
G
S
V
P
P
D
L
D
W
K
G
Q
P
P
A
P
-
P
K
K
G
L
L
Q
R
L
F
S
-------------------
68
PsiBlast_CBE
55.46
39%
-97
- C1 -
3OCB
1
AKT1_HUMAN
B:
[6-288]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
T
M
N
E
F
E
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
K
E
---
K
A
-----
T
G
----
R
Y
Y
A
M
K
I
L
K
K
E
V
I
-
V
A
K
-
D
---
E
V
A
H
T
L
T
E
N
R
V
-
L
Q
N
-
S
-
R
H
P
---
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
----
E
R
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
K
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
K
D
G
----
H
I
K
I
T
D
F
G
L
C
K
E
G
I
-
K
D
G
A
-
T
M
K
T
F
C
----
G
T
P
E
Y
L
A
P
E
V
L
E
-
D
N
D
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
Y
N
Q
D
H
----
E
K
L
F
E
L
I
L
M
----
E
E
I
R
F
P
R
T
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
R
L
G
G
G
S
-
E
D
A
K
E
-
I
M
Q
H
R
F
F
A
G
I
V
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
P
Q
V
T
S
E
T
D
T
R
Y
F
D
E
E
F
T
A
Q
--
M
I
T
I
T
R
P
H
F
P
Q
F
D
Y
S
A
S
S
--------------------------------------------------------------------------
52
PsiBlast_CBE
55.46
39%
-98
- C1 -
2X39
1
AKT2_HUMAN
A:
[7-288]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
T
M
N
D
F
D
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
R
E
---
K
A
-----
T
G
----
R
Y
Y
A
M
K
I
L
R
K
E
V
I
-
I
A
K
-
D
---
E
V
A
H
T
V
T
E
S
R
V
-
L
Q
N
-
T
-
R
H
P
---
F
L
T
A
L
K
Y
A
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
----
E
R
V
F
T
E
E
R
A
R
F
Y
G
A
E
I
V
S
A
L
E
Y
L
H
S
R
D
-
V
V
Y
R
D
I
K
L
E
N
L
M
L
D
K
D
G
----
H
I
K
I
T
D
F
G
L
C
K
E
G
I
-
S
D
G
A
-
T
M
K
T
F
C
----
G
T
P
E
Y
L
A
P
E
V
L
E
-
D
N
D
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
Y
N
Q
D
H
----
E
R
L
F
E
L
I
L
M
----
E
E
I
R
F
P
R
T
L
S
P
E
A
K
S
L
L
A
G
L
L
K
K
D
P
K
Q
R
L
G
G
G
P
-
S
D
A
K
E
-
V
M
E
H
R
F
F
L
S
I
N
W
Q
D
V
V
Q
K
K
L
L
P
P
F
K
P
Q
V
T
S
E
V
D
T
R
Y
F
D
D
E
F
T
A
Q
--
S
I
T
Q
E
M
F
E
D
F
D
Y
I
A
D
W
----------------------------------------------------------------------------
6
PsiBlast_PDB
55.44
66%
31
- C1 -
3NYO
2
GRK6_HUMAN
A:
[4-557]
-
E
L
E
N
I
V
A
N
T
V
L
L
K
A
R
E
G
G
G
G
N
R
K
G
---
K
S
K
K
W
R
Q
M
L
Q
F
P
H
I
S
Q
C
E
E
L
R
L
S
L
E
R
D
Y
H
S
L
C
E
R
---
Q
P
I
G
R
L
L
F
R
E
F
C
-----
A
T
R
P
E
L
S
R
C
V
A
F
L
D
G
V
A
E
Y
E
-
V
T
P
D
D
K
R
K
A
C
G
R
Q
L
T
Q
N
F
L
S
H
T
G
P
D
---
L
I
P
E
V
P
R
Q
L
V
T
N
C
T
Q
R
L
-
E
Q
G
P
C
K
D
L
F
Q
E
L
T
R
L
T
H
E
Y
L
S
V
A
P
F
A
D
Y
L
D
S
I
Y
F
N
R
F
L
Q
W
K
W
L
E
R
Q
-
P
V
T
K
N
T
F
R
Q
Y
R
V
L
G
K
G
G
F
G
E
V
C
A
C
Q
V
---
R
A
-----
T
G
----
K
M
Y
A
C
K
K
L
E
K
K
R
I
-
K
K
R
-
K
---
G
E
A
M
A
L
N
E
K
Q
I
-
L
E
K
-
V
-
N
S
R
---
F
V
V
S
L
A
Y
A
Y
E
T
K
D
A
L
C
L
V
L
T
L
M
N
G
G
D
L
K
F
H
I
Y
H
M
G
--
Q
A
G
F
P
E
A
R
A
V
F
Y
A
A
E
I
C
C
G
L
E
D
L
H
R
E
R
-
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
D
H
G
----
H
I
R
I
S
D
L
G
L
A
V
H
-
V
-
P
E
G
Q
-
T
I
K
G
R
V
----
G
T
V
G
Y
M
A
P
E
V
V
K
-
N
E
R
Y
T
F
S
P
D
W
W
A
L
G
C
L
L
Y
E
M
I
A
G
Q
S
P
F
Q
---
K
K
I
K
R
E
E
V
E
R
L
V
K
E
----
V
P
E
E
Y
S
E
R
F
S
P
Q
A
R
S
L
C
S
Q
L
L
C
K
D
P
A
E
R
L
G
C
R
G
-
G
S
A
R
E
-
V
K
E
H
P
L
F
K
K
L
N
F
K
R
L
G
A
G
M
L
E
P
P
F
K
P
D
P
Q
A
I
Y
C
K
D
V
L
D
I
E
Q
F
S
T
--
V
K
G
V
E
L
E
P
T
D
Q
D
F
Y
Q
K
F
A
T
G
S
V
P
I
P
W
Q
N
E
M
V
E
T
E
C
F
Q
E
L
N
V
F
G
L
D
G
S
V
P
P
D
L
D
W
K
G
Q
P
P
A
P
-
P
K
K
G
L
L
Q
R
L
F
S
-------------------
62
PsiBlast_CBE
55.16
39%
-97
- C1 -
4EKK
1
AKT1_HUMAN
A:
[6-288]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
T
M
N
E
F
E
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
K
E
---
K
A
-----
T
G
----
R
Y
Y
A
M
K
I
L
K
K
E
V
I
-
V
A
K
-
D
---
E
V
A
H
T
L
T
E
N
R
V
-
L
Q
N
-
S
-
R
H
P
---
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
----
E
R
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
K
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
K
D
G
----
H
I
K
I
T
D
F
G
L
C
K
E
G
I
-
K
D
G
A
-
T
M
K
T
F
C
----
G
T
P
E
Y
L
A
P
E
V
L
E
-
D
N
D
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
Y
N
Q
D
H
----
E
K
L
F
E
L
I
L
M
----
E
E
I
R
F
P
R
T
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
R
L
G
G
G
S
-
E
D
A
K
E
-
I
M
Q
H
R
F
F
A
G
I
V
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
P
Q
V
T
S
E
T
D
T
R
Y
F
D
E
E
F
T
A
Q
--
M
I
S
E
R
R
P
H
F
P
Q
F
D
Y
S
A
S
---------------------------------------------------------------------------
23
PsiBlast_CBE
55.02
66%
34
- C1 -
3NYN
2
GRK6_HUMAN
B:
[4-557]
-
E
L
E
N
I
V
A
N
T
V
L
L
K
A
R
E
G
G
G
G
N
R
K
G
---
K
S
K
K
W
R
Q
M
L
Q
F
P
H
I
S
Q
C
E
E
L
R
L
S
L
E
R
D
Y
H
S
L
C
E
R
---
Q
P
I
G
R
L
L
F
R
E
F
C
-----
A
T
R
P
E
L
S
R
C
V
A
F
L
D
G
V
A
E
Y
E
-
V
T
P
D
D
K
R
K
A
C
G
R
Q
L
T
Q
N
F
L
S
H
T
G
P
D
---
L
I
P
E
V
P
R
Q
L
V
T
N
C
T
Q
R
L
-
E
Q
G
P
C
K
D
L
F
Q
E
L
T
R
L
T
H
E
Y
L
S
V
A
P
F
A
D
Y
L
D
S
I
Y
F
N
R
F
L
Q
W
K
W
L
E
R
Q
-
P
V
T
K
N
T
F
R
Q
Y
R
V
L
G
K
G
G
F
G
E
V
C
A
C
Q
V
---
R
A
-----
T
G
----
K
M
Y
A
C
K
K
L
E
K
K
R
I
-
K
K
R
-
K
---
G
E
A
M
A
L
N
E
K
Q
I
-
L
E
K
-
V
-
N
S
R
---
F
V
V
S
L
A
Y
A
Y
E
T
K
D
A
L
C
L
V
L
T
L
M
N
G
G
D
L
K
F
H
I
Y
H
M
G
--
Q
A
G
F
P
E
A
R
A
V
F
Y
A
A
E
I
C
C
G
L
E
D
L
H
R
E
R
-
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
D
H
G
----
H
I
R
I
S
D
L
G
L
A
V
H
-
V
-
P
E
G
Q
-
T
I
K
G
R
V
----
G
T
V
G
Y
M
A
P
E
V
V
K
-
N
E
R
Y
T
F
S
P
D
W
W
A
L
G
C
L
L
Y
E
M
I
A
G
Q
S
P
F
Q
---
K
K
I
K
R
E
E
V
E
R
L
V
K
E
----
V
P
E
E
Y
S
E
R
F
S
P
Q
A
R
S
L
C
S
Q
L
L
C
K
D
P
A
E
R
L
G
C
R
G
-
G
S
A
R
E
-
V
K
E
H
P
L
F
K
K
L
N
F
K
R
L
G
A
G
M
L
E
P
P
F
K
P
D
P
Q
A
I
Y
C
K
D
V
L
D
I
E
Q
F
S
T
--
V
K
G
V
E
L
E
P
T
D
Q
D
F
Y
Q
K
F
A
T
G
S
V
P
I
P
W
Q
N
E
M
V
E
T
E
C
F
Q
E
L
N
V
F
G
L
D
G
S
V
P
P
D
L
D
W
K
G
Q
P
P
A
P
-
P
K
K
G
L
L
Q
R
L
F
S
-------------------
61
PsiBlast_CBE
54.98
39%
-96
- C1 -
4EKK
1
AKT1_HUMAN
B:
[6-288]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
T
M
N
E
F
E
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
K
E
---
K
A
-----
T
G
----
R
Y
Y
A
M
K
I
L
K
K
E
V
I
-
V
A
K
-
D
---
E
V
A
H
T
L
T
E
N
R
V
-
L
Q
N
-
S
-
R
H
P
---
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
----
E
R
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
K
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
K
D
G
----
H
I
K
I
T
D
F
G
L
C
K
E
G
I
-
K
D
G
A
-
T
M
K
T
F
C
----
G
T
P
E
Y
L
A
P
E
V
L
E
-
D
N
D
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
Y
N
Q
D
H
----
E
K
L
F
E
L
I
L
M
----
E
E
I
R
F
P
R
T
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
R
L
G
G
G
S
-
E
D
A
K
E
-
I
M
Q
H
R
F
F
A
G
I
V
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
P
Q
V
T
S
E
T
D
T
R
Y
F
D
E
E
F
T
A
Q
--
M
I
S
E
R
R
P
H
F
P
Q
F
D
Y
S
A
S
---------------------------------------------------------------------------
59
PsiBlast_CBE
54.96
39%
-95
- C1 -
3CQU
1
AKT1_HUMAN
A:
[7-289]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
T
M
N
E
F
E
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
K
E
---
K
A
-----
T
G
----
R
Y
Y
A
M
K
I
L
K
K
E
V
I
-
V
A
K
-
D
---
E
V
A
H
T
L
T
E
N
R
V
-
L
Q
N
-
S
-
R
H
P
---
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
----
E
R
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
K
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
K
D
G
----
H
I
K
I
T
D
F
G
L
C
K
E
G
I
-
K
D
G
A
-
T
M
K
T
F
C
----
G
T
P
E
Y
L
A
P
E
V
L
E
-
D
N
D
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
Y
N
Q
D
H
----
E
K
L
F
E
L
I
L
M
----
E
E
I
R
F
P
R
T
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
R
L
G
G
G
S
-
E
D
A
K
E
-
I
M
Q
H
R
F
F
A
G
I
V
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
P
Q
V
T
S
E
T
D
T
R
Y
F
D
E
E
F
T
A
Q
--
M
S
E
R
R
P
H
F
P
Q
F
D
Y
S
A
S
S
---------------------------------------------------------------------------
69
PsiBlast_CBE
54.68
39%
-94
- C1 -
3OCB
1
AKT1_HUMAN
A:
[6-288]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
T
M
N
E
F
E
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
K
E
---
K
A
-----
T
G
----
R
Y
Y
A
M
K
I
L
K
K
E
V
I
-
V
A
K
-
D
---
E
V
A
H
T
L
T
E
N
R
V
-
L
Q
N
-
S
-
R
H
P
---
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
----
E
R
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
K
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
K
D
G
----
H
I
K
I
T
D
F
G
L
C
K
E
G
I
-
K
D
G
A
-
T
M
K
T
F
C
----
G
T
P
E
Y
L
A
P
E
V
L
E
-
D
N
D
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
Y
N
Q
D
H
----
E
K
L
F
E
L
I
L
M
----
E
E
I
R
F
P
R
T
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
R
L
G
G
G
S
-
E
D
A
K
E
-
I
M
Q
H
R
F
F
A
G
I
V
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
P
Q
V
T
S
E
T
D
T
R
Y
F
D
E
E
F
T
A
Q
--
M
R
P
H
F
P
Q
F
D
Y
S
A
S
S
------------------------------------------------------------------------------
54
PsiBlast_CBE
54.60
39%
-93
- C1 -
2JDR
1
AKT2_HUMAN
A:
[7-288]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
T
M
N
D
F
D
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
R
E
---
K
A
-----
T
G
----
R
Y
Y
A
M
K
I
L
R
K
E
V
I
-
I
A
K
-
D
---
E
V
A
H
T
V
T
E
S
R
V
-
L
Q
N
-
T
-
R
H
P
---
F
L
T
A
L
K
Y
A
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
----
E
R
V
F
T
E
E
R
A
R
F
Y
G
A
E
I
V
S
A
L
E
Y
L
H
S
R
D
-
V
V
Y
R
D
I
K
L
E
N
L
M
L
D
K
D
G
----
H
I
K
I
T
D
F
G
L
C
K
E
G
I
-
S
D
G
A
-
T
M
K
T
F
C
----
G
T
P
E
Y
L
A
P
E
V
L
E
-
D
N
D
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
Y
N
Q
D
H
----
E
R
L
F
E
L
I
L
M
----
E
E
I
R
F
P
R
T
L
S
P
E
A
K
S
L
L
A
G
L
L
K
K
D
P
K
Q
R
L
G
G
G
P
-
S
D
A
K
E
-
V
M
E
H
R
F
F
L
S
I
N
W
Q
D
V
V
Q
K
K
L
L
P
P
F
K
P
Q
V
T
S
E
V
D
T
R
Y
F
D
D
E
F
T
A
Q
--
S
I
T
Q
E
M
F
E
D
F
D
Y
I
A
D
W
----------------------------------------------------------------------------
64
PsiBlast_CBE
54.57
39%
-95
- C1 -
3QKL
1
AKT1_HUMAN
A:
[6-288]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
T
M
N
E
F
E
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
K
E
---
K
A
-----
T
G
----
R
Y
Y
A
M
K
I
L
K
K
E
V
I
-
V
A
K
-
D
---
E
V
A
H
T
L
T
E
N
R
V
-
L
Q
N
-
S
-
R
H
P
---
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
----
E
R
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
K
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
K
D
G
----
H
I
K
I
T
D
F
G
L
C
K
E
G
I
-
K
D
G
A
-
T
M
K
T
F
C
----
G
T
P
E
Y
L
A
P
E
V
L
E
-
D
N
D
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
Y
N
Q
D
H
----
E
K
L
F
E
L
I
L
M
----
E
E
I
R
F
P
R
T
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
R
L
G
G
G
S
-
E
D
A
K
E
-
I
M
Q
H
R
F
F
A
G
I
V
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
P
Q
V
T
S
E
T
D
T
R
Y
F
D
E
E
F
T
A
Q
--
M
I
T
R
P
H
F
P
Q
F
D
Y
S
A
S
S
----------------------------------------------------------------------------
55
PsiBlast_CBE
54.56
39%
-95
- C1 -
2JDO
2
AKT2_HUMAN
A:
[7-288]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
T
M
N
D
F
D
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
R
E
---
K
A
-----
T
G
----
R
Y
Y
A
M
K
I
L
R
K
E
V
I
-
I
A
K
-
D
---
E
V
A
H
T
V
T
E
S
R
V
-
L
Q
N
-
T
-
R
H
P
---
F
L
T
A
L
K
Y
A
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
----
E
R
V
F
T
E
E
R
A
R
F
Y
G
A
E
I
V
S
A
L
E
Y
L
H
S
R
D
-
V
V
Y
R
D
I
K
L
E
N
L
M
L
D
K
D
G
----
H
I
K
I
T
D
F
G
L
C
K
E
G
I
-
S
D
G
A
-
T
M
K
T
F
C
----
G
T
P
E
Y
L
A
P
E
V
L
E
-
D
N
D
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
Y
N
Q
D
H
----
E
R
L
F
E
L
I
L
M
----
E
E
I
R
F
P
R
T
L
S
P
E
A
K
S
L
L
A
G
L
L
K
K
D
P
K
Q
R
L
G
G
G
P
-
S
D
A
K
E
-
V
M
E
H
R
F
F
L
S
I
N
W
Q
D
V
V
Q
K
K
L
L
P
P
F
K
P
Q
V
T
S
E
V
D
T
R
Y
F
D
D
E
F
T
A
Q
--
S
I
T
M
F
E
D
F
D
Y
I
A
D
W
------------------------------------------------------------------------------
67
PsiBlast_CBE
53.88
39%
-100
- C1 -
3OW4
1
AKT1_HUMAN
A:
[6-288]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
T
M
N
E
F
E
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
K
E
---
K
A
-----
T
G
----
R
Y
Y
A
M
K
I
L
K
K
E
V
I
-
V
A
K
-
D
---
E
V
A
H
T
L
T
E
N
R
V
-
L
Q
N
-
S
-
R
H
P
---
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
----
E
R
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
K
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
K
D
G
----
H
I
K
I
T
D
F
G
L
C
K
E
G
I
-
K
D
G
A
-
T
M
K
T
F
C
----
G
T
P
E
Y
L
A
P
E
V
L
E
-
D
N
D
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
Y
N
Q
D
H
----
E
K
L
F
E
L
I
L
M
----
E
E
I
R
F
P
R
T
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
R
L
G
G
G
S
-
E
D
A
K
E
-
I
M
Q
H
R
F
F
A
G
I
V
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
P
Q
V
T
S
E
T
D
T
R
Y
F
D
E
E
F
T
A
Q
--
M
I
T
R
P
H
F
P
Q
F
D
Y
S
A
S
S
----------------------------------------------------------------------------
51
PsiBlast_CBE
53.04
39%
-98
- C1 -
2XH5
1
AKT2_HUMAN
A:
[7-288]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
T
M
N
D
F
D
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
R
E
---
K
A
-----
T
G
----
R
Y
Y
A
M
K
I
L
R
K
E
V
I
-
I
A
K
-
D
---
E
V
A
H
T
V
T
E
S
R
V
-
L
Q
N
-
T
-
R
H
P
---
F
L
T
A
L
K
Y
A
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
----
E
R
V
F
T
E
E
R
A
R
F
Y
G
A
E
I
V
S
A
L
E
Y
L
H
S
R
D
-
V
V
Y
R
D
I
K
L
E
N
L
M
L
D
K
D
G
----
H
I
K
I
T
D
F
G
L
C
K
E
G
I
-
S
D
G
A
-
T
M
K
T
F
C
----
G
T
P
E
Y
L
A
P
E
V
L
E
-
D
N
D
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
Y
N
Q
D
H
----
E
R
L
F
E
L
I
L
M
----
E
E
I
R
F
P
R
T
L
S
P
E
A
K
S
L
L
A
G
L
L
K
K
D
P
K
Q
R
L
G
G
G
P
-
S
D
A
K
E
-
V
M
E
H
R
F
F
L
S
I
N
W
Q
D
V
V
Q
K
K
L
L
P
P
F
K
P
Q
V
T
S
E
V
D
T
R
Y
F
D
D
E
F
T
A
Q
--
S
I
T
Q
E
M
F
E
D
F
D
Y
I
A
D
W
----------------------------------------------------------------------------
45
PsiBlast_CBE
52.64
38%
-91
- C1 -
4RA5
1
B:
[7-280]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
L
H
K
M
L
G
K
G
S
F
G
K
V
F
L
A
E
F
---
K
K
-----
T
N
----
Q
F
F
A
I
K
A
L
K
K
D
V
V
-
L
M
D
-
D
---
D
V
E
C
T
M
V
E
K
R
V
-
L
S
L
-
A
W
E
H
P
---
F
L
T
H
M
F
C
T
F
Q
T
K
E
N
L
F
F
V
M
E
Y
L
N
G
G
D
L
M
Y
H
I
Q
S
C
H
--
K
--
F
D
L
S
R
A
T
F
Y
A
A
E
I
I
L
G
L
Q
F
L
H
S
K
G
-
I
V
Y
R
D
L
K
L
D
N
I
L
L
D
K
D
G
----
H
I
K
I
A
D
F
G
M
C
K
E
-
N
-
M
L
G
D
A
K
T
N
E
F
C
----
G
T
P
D
Y
I
A
P
E
I
L
L
-
G
Q
K
Y
N
H
S
V
D
W
W
S
F
G
V
L
L
Y
E
M
L
I
G
Q
S
P
F
H
G
Q
D
E
----
E
E
L
F
H
S
I
R
M
----
D
N
P
F
Y
P
R
W
L
E
K
E
A
K
D
L
L
V
K
L
F
V
R
E
P
E
K
R
L
G
V
R
G
-
D
-----
I
R
Q
H
P
L
F
R
E
I
N
W
E
E
L
E
R
K
E
I
D
P
P
F
R
P
K
V
K
S
P
F
D
P
R
L
S
R
A
L
I
N
S
M
--
D
Q
N
M
F
R
N
F
S
F
M
N
P
G
M
-----------------------------------------------------------------------------
124
HHSearch
51.52
32%
-82
- C1 -
1RDQ
3
KAPCA_MOUSE
E:
[28-331]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
K
W
E
T
P
S
Q
N
-
T
A
Q
L
D
Q
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
---
K
E
-----
S
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
-
V
K
L
-
K
---
Q
I
E
H
T
L
N
E
K
R
I
-
L
Q
A
-
V
-
N
F
P
---
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
G
----
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
----
Y
I
Q
V
T
D
F
G
F
A
K
R
-
V
-
K
G
R
---
T
W
T
L
C
----
G
T
P
E
A
L
A
P
E
I
I
L
-
S
K
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
----
Q
P
I
Q
I
Y
E
K
I
V
S
----
G
K
V
R
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
L
K
-
N
G
V
N
D
-
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
-----
G
P
G
D
T
S
N
F
D
D
--
Y
E
E
E
E
I
R
V
S
I
N
E
K
C
G
K
E
F
T
E
F
-----------------------------------------------------------------------
43
PsiBlast_CBE
51.27
39%
-92
- C1 -
4RA4
1
A:
[17-299]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
K
L
T
D
F
N
F
L
M
V
L
G
K
G
S
F
G
K
V
M
L
A
D
R
---
K
G
-----
T
E
----
E
L
Y
A
I
K
I
L
K
K
D
V
V
-
I
Q
D
-
D
---
D
V
E
C
T
M
V
E
K
R
V
-
L
A
L
-
L
D
K
P
P
---
F
L
T
Q
L
H
S
C
F
Q
T
V
D
R
L
Y
F
V
M
E
Y
V
N
G
G
D
L
M
Y
H
I
Q
Q
V
G
--
K
--
F
K
E
P
Q
A
V
F
Y
A
A
E
I
S
I
G
L
F
F
L
H
K
R
G
-
I
I
Y
R
D
L
K
L
D
N
V
M
L
D
S
E
G
----
H
I
K
I
A
D
F
G
M
C
K
E
H
M
-
M
D
G
V
-
T
T
R
T
F
C
----
G
T
P
D
Y
I
A
P
E
I
I
A
-
Y
Q
P
Y
G
K
S
V
D
W
W
A
Y
G
V
L
L
Y
E
M
L
A
G
Q
P
P
F
D
G
E
D
E
----
D
E
L
F
Q
S
I
M
E
----
H
N
V
S
Y
P
K
S
L
S
K
E
A
V
S
I
C
K
G
L
M
T
K
H
P
A
K
R
L
G
C
G
P
-
E
G
E
R
D
-
V
R
E
H
A
F
F
R
R
I
D
W
E
K
L
E
N
R
E
I
Q
P
P
F
K
P
K
G
Q
P
V
L
T
P
P
D
Q
L
V
I
A
N
I
D
--
Q
S
D
F
E
G
F
S
Y
V
N
P
Q
F
V
H
P
---------------------------------------------------------------------------
127
HHSearch
51.15
39%
-88
- C1 -
3TXO
1
A:
[23-314]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
N
F
E
F
I
R
V
L
G
K
G
S
F
G
K
V
M
L
A
R
V
---
K
E
-----
T
G
----
D
L
Y
A
V
K
V
L
K
K
D
V
I
-
L
Q
D
-
D
---
D
V
E
C
T
M
T
E
K
R
I
-
L
S
L
-
A
R
N
H
P
---
F
L
T
Q
L
F
C
C
F
Q
T
P
D
R
L
F
F
V
M
E
F
V
N
G
G
D
L
M
F
H
I
Q
K
S
----
R
R
F
D
E
A
R
A
R
F
Y
A
A
E
I
I
S
A
L
M
F
L
H
D
K
G
-
I
I
Y
R
D
L
K
L
D
N
V
L
L
D
H
E
G
----
H
C
K
L
A
D
F
G
M
C
K
E
-
G
I
C
--------------
G
T
P
D
Y
I
A
P
E
I
L
Q
-
E
M
L
Y
G
P
A
V
D
W
W
A
M
G
V
L
L
Y
E
M
L
C
G
H
A
P
F
E
A
E
----
N
E
D
D
L
F
E
A
I
L
N
----
D
E
V
V
Y
P
T
W
L
H
E
D
A
T
G
I
L
K
S
F
M
T
K
N
P
T
M
R
L
G
S
L
T
Q
G
G
E
H
A
-
I
L
R
H
P
F
F
K
E
I
D
W
A
Q
L
N
H
R
Q
I
E
P
P
F
R
P
R
I
-----
K
S
R
E
D
V
S
N
F
D
P
--
D
F
I
K
E
E
P
V
L
T
P
I
D
E
G
H
L
P
M
I
N
Q
D
E
F
R
N
F
E
Y
V
S
P
-----------------------------------------------------------
130
HHSearch
50.62
38%
-101
- C1 -
2R5T
1
SGK1_HUMAN
A:
[34-318]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
A
K
P
S
D
F
H
F
L
K
V
I
G
K
G
S
F
G
K
V
L
L
A
R
H
---
K
A
-----
E
E
----
V
F
Y
A
V
K
V
L
Q
K
K
A
I
-
L
-----------------
V
L
L
K
N
-
V
-
K
H
P
---
F
L
V
G
L
H
F
S
F
Q
T
A
D
K
L
Y
F
V
L
D
Y
I
N
G
G
E
L
F
Y
H
L
Q
R
E
----
R
C
F
L
E
P
R
A
R
F
Y
A
A
E
I
A
S
A
L
G
Y
L
H
S
L
N
-
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
S
Q
G
----
H
I
V
L
T
D
F
G
L
C
K
E
-
N
I
E
H
N
S
-
T
T
S
T
F
C
----
G
T
P
E
Y
L
A
P
E
V
L
H
-
K
Q
P
Y
D
R
T
V
D
W
W
C
L
G
A
V
L
Y
E
M
L
Y
G
L
P
P
F
Y
S
R
----
N
T
A
E
M
Y
D
N
I
L
N
----
K
P
L
Q
L
K
P
N
I
T
N
S
A
R
H
L
L
E
G
L
L
Q
K
D
R
T
K
R
L
G
A
K
--
D
D
F
M
E
-
I
K
S
H
V
F
F
S
L
I
N
W
D
D
L
I
N
K
K
I
T
P
P
F
N
P
N
V
S
G
------------------------------------------------------------------------------------------------------------
47
PsiBlast_CBE
50.52
38%
-87
- C1 -
4Q9Z
1
B:
[7-280]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
L
H
K
M
L
G
K
G
S
F
G
K
V
F
L
A
E
F
---
K
K
-----
T
N
----
Q
F
F
A
I
K
A
L
K
K
D
V
V
-
L
M
D
-
D
---
D
V
E
C
T
M
V
E
K
R
V
-
L
S
L
-
A
W
E
H
P
---
F
L
T
H
M
F
C
T
F
Q
T
K
E
N
L
F
F
V
M
E
Y
L
N
G
G
D
L
M
Y
H
I
Q
S
C
H
--
K
--
F
D
L
S
R
A
T
F
Y
A
A
E
I
I
L
G
L
Q
F
L
H
S
K
G
-
I
V
Y
R
D
L
K
L
D
N
I
L
L
D
K
D
G
----
H
I
K
I
A
D
F
G
M
C
K
E
-
N
-
M
L
G
D
A
K
T
N
E
F
C
----
G
T
P
D
Y
I
A
P
E
I
L
L
-
G
Q
K
Y
N
H
S
V
D
W
W
S
F
G
V
L
L
Y
E
M
L
I
G
Q
S
P
F
H
G
Q
D
E
----
E
E
L
F
H
S
I
R
M
----
D
N
P
F
Y
P
R
W
L
E
K
E
A
K
D
L
L
V
K
L
F
V
R
E
P
E
K
R
L
G
V
R
G
-
D
-----
I
R
Q
H
P
L
F
R
E
I
N
W
E
E
L
E
R
K
E
I
D
P
P
F
R
P
K
V
K
S
P
F
D
C
S
N
F
D
K
N
M
F
R
N
--
F
S
F
M
N
P
G
M
E
R
L
---------------------------------------------------------------------------------
103
PsiBlast_CBE
50.41
34%
-91
- C1 -
2UZT
1
KAPCA_BOVIN
A:
[27-302]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
---
M
E
-----
T
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
-
V
K
L
-
K
---
Q
I
E
H
T
L
N
E
K
R
I
-
L
Q
A
-
V
-
N
F
P
---
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
--
R
--
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
----
Y
I
Q
V
T
D
F
G
F
A
--------
K
-
R
V
K
G
R
T
W
T
LC
G
T
P
E
Y
L
A
P
E
I
I
L
-
S
K
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
----
Q
I
Y
E
K
I
V
S
----
G
K
V
R
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
L
K
-
D
G
V
N
D
-
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
--
I
R
V
S
I
N
E
K
C
G
K
E
F
S
E
F
----------------------------------------------------------------------------
105
PsiBlast_CBE
50.40
34%
-87
- C1 -
2OJF
1
KAPCA_BOVIN
E:
[42-317]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
---
M
E
-----
T
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
-
V
K
L
-
K
---
Q
I
E
H
T
L
N
E
K
R
I
-
L
Q
A
-
V
-
N
F
P
---
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
--
R
--
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
----
Y
I
Q
V
T
D
F
G
F
A
--------
K
-
R
V
K
G
R
T
WTLC
G
T
P
E
Y
L
A
P
E
I
I
L
-
S
K
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
----
Q
I
Y
E
K
I
V
S
----
G
K
V
R
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
L
K
-
N
G
V
N
D
-
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
--
I
R
V
S
I
N
E
K
C
G
K
E
F
S
E
F
----------------------------------------------------------------------------
102
PsiBlast_CBE
50.15
34%
-90
- C1 -
2UZU
1
KAPCA_BOVIN
E:
[27-302]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
---
M
E
-----
T
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
-
V
K
L
-
K
---
Q
I
E
H
T
L
N
E
K
R
I
-
L
Q
A
-
V
-
N
F
P
---
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
--
R
--
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
----
Y
I
Q
V
T
D
F
G
F
A
--------
K
-
R
V
K
G
R
T
WTLC
G
T
P
E
Y
L
A
P
E
I
I
L
-
S
K
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
----
Q
I
Y
E
K
I
V
S
----
G
K
V
R
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
L
K
-
D
G
V
N
D
-
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
--
I
R
V
S
I
N
E
K
C
G
K
E
F
S
E
F
----------------------------------------------------------------------------
75
PsiBlast_CBE
50.07
39%
-94
- C1 -
4L45
1
KS6B1_HUMAN
A:
[20-300]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
L
L
R
V
L
G
K
G
G
Y
G
K
V
F
--
Q
V
---
R
K
VTGAN
T
G
----
K
I
F
A
M
K
V
L
K
K
A
M
I
V
R
N
A
-
K
---
D
T
A
H
T
K
A
E
R
N
I
-
L
E
E
-
V
-
K
H
P
---
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
E
G
--
I
--
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
K
G
-
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
H
Q
G
----
H
V
K
L
T
D
F
G
L
C
K
E
S-----------------
G
T
I
E
Y
M
A
P
E
I
L
M
-
R
S
G
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
P
P
F
T
G
E
N
R
K
K
T
I
D
K
I
-
L
K
C
K
L
----
N
L
P
P
Y
---
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
R
L
G
A
-
G
-
P
G
D
A
G
E
V
Q
A
H
P
F
F
R
H
I
N
W
E
E
L
L
A
R
K
V
E
P
P
F
K
P
L
L
Q
S
E
E
D
V
S
Q
F
D
S
K
F
T
R
Q
--
T
P
V
E
S
A
N
Q
V
F
L
G
F
E
Y
V
A
P
S
-------------------------------------------------------------------------
74
PsiBlast_CBE
49.58
39%
-95
- C1 -
4L43
1
KS6B1_HUMAN
A:
[20-300]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
L
L
R
V
L
G
K
G
G
Y
G
K
V
F
--
Q
V
---
R
K
VTGAN
T
G
----
K
I
F
A
M
K
V
L
K
K
A
M
I
V
R
N
A
-
K
---
D
T
A
H
T
K
A
E
R
N
I
-
L
E
E
-
V
-
K
H
P
---
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
E
G
--
I
--
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
K
G
-
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
H
Q
G
----
H
V
K
L
T
D
F
G
L
C
K
E
S-----------------
G
T
I
E
Y
M
A
P
E
I
L
M
-
R
S
G
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
P
P
F
T
G
E
N
R
K
K
T
I
D
K
I
-
L
K
C
K
L
----
N
L
P
P
Y
---
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
R
L
G
A
-
G
-
P
G
D
A
G
E
V
Q
A
H
P
F
F
R
H
I
N
W
E
E
L
L
A
R
K
V
E
P
P
F
K
P
L
L
Q
S
E
E
D
V
S
Q
F
D
S
K
F
T
R
Q
--
T
P
V
S
A
N
Q
V
F
L
G
F
A
Y
V
A
P
S
--------------------------------------------------------------------------
134
HHSearch
49.54
36%
-87
- C1 -
3WF7
2
KS6B1_HUMAN
A:
[14-304]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
-
K
I
R
P
E
C
F
E
L
L
R
V
L
G
K
G
G
Y
G
K
V
F
Q
V
R
K
VTG
A
N
-----
T
G
----
K
I
F
A
M
K
V
L
K
K
A
M
I
-
V
R
N
A
K
---
D
T
A
H
T
K
A
E
R
N
I
-
L
E
E
-
V
-
K
H
P
---
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
E
G
----
I
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
K
G
-
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
H
Q
G
----
H
V
K
L
T
D
F
G
L
C
K
E
-
S
I
H
D
----
T
H
T
F
C
----
G
T
I
E
Y
M
A
P
E
I
L
M
-
R
S
G
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
P
P
F
T
G
E
----
N
R
K
K
T
I
D
K
I
L
K
----
C
K
L
N
L
P
P
Y
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
R
L
G
A
G
P
-
G
D
A
G
E
-
V
Q
A
H
P
F
F
R
H
I
N
W
E
E
L
L
A
R
K
V
E
P
P
F
K
P
L
L
Q
-------------------------------------------------------------------------------------------------------------
100
PsiBlast_CBE
49.43
34%
-89
- C1 -
2UZW
1
KAPCA_BOVIN
E:
[27-302]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
---
M
E
-----
T
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
-
V
K
L
-
K
---
Q
I
E
H
T
L
N
E
K
R
I
-
L
Q
A
-
V
-
N
F
P
---
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
--
R
--
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
----
Y
I
Q
V
T
D
F
G
F
A
--------
K
-
R
V
K
G
R
T
WTLC
G
T
P
E
Y
L
A
P
E
I
I
L
-
S
K
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
----
Q
I
Y
E
K
I
V
S
----
G
K
V
R
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
L
K
-
D
G
V
N
D
-
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
--
I
R
V
S
I
N
E
K
C
G
K
E
F
S
E
F
----------------------------------------------------------------------------
101
PsiBlast_CBE
49.21
34%
-87
- C1 -
2UZV
1
KAPCA_BOVIN
A:
[27-302]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
---
M
E
-----
T
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
-
V
K
L
-
K
---
Q
I
E
H
T
L
N
E
K
R
I
-
L
Q
A
-
V
-
N
F
P
---
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
--
R
--
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
----
Y
I
Q
V
T
D
F
G
F
A
--------
K
-
R
V
K
G
R
T
W
T
LC
G
T
P
E
Y
L
A
P
E
I
I
L
-
S
K
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
----
Q
I
Y
E
K
I
V
S
----
G
K
V
R
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
L
K
-
D
G
V
N
D
-
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
--
I
R
V
S
I
N
E
K
C
G
K
E
F
S
E
F
----------------------------------------------------------------------------
98
PsiBlast_CBE
47.88
38%
-103
- C1 -
2R5T
1
SGK1_HUMAN
A:
[40-317]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
H
F
L
K
V
I
G
K
G
S
F
G
K
V
L
L
A
R
H
---
K
A
-----
E
E
----
V
F
Y
A
V
K
V
L
Q
K
K
A
I
-
L
-----------------
V
-
L
L
K
N
V
-
K
H
P
---
F
L
V
G
L
H
F
S
F
Q
T
A
D
K
L
Y
F
V
L
D
Y
I
N
G
G
E
L
F
Y
H
L
Q
R
----
E
R
C
F
L
E
P
R
A
R
F
Y
A
A
E
I
A
S
A
L
G
Y
L
H
S
L
N
-
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
S
Q
G
----
H
I
V
L
T
D
F
G
L
C
K
E
N
I
-
E
H
N
S
-
T
T
S
T
F
C
----
G
T
P
E
Y
L
A
P
E
V
L
H
-
K
Q
P
Y
D
R
T
V
D
W
W
C
L
G
A
V
L
Y
E
M
L
Y
G
L
P
P
F
--
Y
S
R
N
T
A
--
E
M
Y
D
N
I
L
N
----
K
P
L
Q
L
K
P
N
I
T
N
S
A
R
H
L
L
E
G
L
L
Q
K
D
R
T
K
R
L
G
A
K
D
-
D
F
M
E
--
I
K
S
H
V
F
F
S
L
I
N
W
D
D
L
I
N
K
K
I
T
P
P
F
N
P
N
V
S
G
------------------------------------------------------------------------------------------------------------
84
PsiBlast_CBE
47.83
39%
-93
- C1 -
4L3J
1
KS6B1_HUMAN
A:
[20-300]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
L
L
R
V
L
G
K
G
G
Y
G
K
V
F
--
Q
V
---
R
K
VTGAN
T
G
----
K
I
F
A
M
K
V
L
K
K
A
M
I
V
R
N
A
-
K
---
D
T
A
H
T
K
A
E
R
N
I
-
L
E
E
-
V
-
K
H
P
---
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
E
G
--
I
--
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
K
G
-
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
H
Q
G
----
H
V
K
L
T
D
F
G
L
C
K
E
S
I
-
H
D
G
T
-
V
T
H
T
F
C
----
G
T
I
E
Y
M
A
P
E
I
L
M
-
R
S
G
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
P
P
F
T
G
E
N
R
K
K
T
I
D
K
I
-
L
K
C
K
L
----
N
L
P
P
Y
---
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
R
L
G
A
-
G
-
P
G
D
A
G
E
V
Q
A
H
P
F
F
R
H
I
N
W
E
E
L
L
A
R
K
V
E
P
P
F
K
P
L
L
Q
S
------------------------------------------------------------------------------------------------------------
76
PsiBlast_CBE
47.77
38%
-97
- C1 -
2Z7S
1
KS6A1_HUMAN
A:
[30-308]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
L
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
V
R
K
---
V
T
RPD--
S
G
----
H
L
Y
A
M
K
V
L
K
-----------------------
I
-
L
A
D
-
V
-
N
H
P
---
F
V
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
----
E
V
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
G
L
D
H
L
H
S
L
G
-
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
G
----
H
I
K
L
T
D
F
G
L
S
K
E
------------------
G
T
V
E
Y
M
A
P
E
V
V
N
-
R
Q
G
H
S
H
S
A
D
W
W
S
Y
G
V
L
M
F
E
M
L
T
G
S
L
P
F
Q
G
K
D
R
K
----
E
T
M
T
L
I
L
K
----
A
K
L
G
M
P
Q
F
L
S
T
E
A
Q
S
L
L
R
A
L
F
K
R
N
P
A
N
R
L
G
S
G
P
-
D
G
A
E
E
-
I
K
R
H
V
F
Y
S
T
I
D
W
N
K
L
Y
R
R
E
I
K
P
P
F
K
P
----------------------------------------------------------------------------------------------------------------
83
PsiBlast_CBE
47.44
39%
-92
- C1 -
4L3L
1
KS6B1_HUMAN
A:
[20-300]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
L
L
R
V
L
G
K
G
G
Y
G
K
V
F
--
Q
V
---
R
K
VTGAN
T
G
----
K
I
F
A
M
K
V
L
K
K
A
M
I
V
R
N
A
-
K
---
D
T
A
H
T
K
A
E
R
N
I
-
L
E
E
-
V
-
K
H
P
---
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
E
G
--
I
--
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
K
G
-
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
H
Q
G
----
H
V
K
L
T
D
F
G
L
C
K
E
S
I
-
H
D
G
T
-
V
T
H
T
F
C
----
G
T
I
E
Y
M
A
P
E
I
L
M
-
R
S
G
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
P
P
F
T
G
E
N
R
K
K
T
I
D
K
I
-
L
K
C
K
L
----
N
L
P
P
Y
---
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
R
L
G
A
-
G
-
P
G
D
A
G
E
V
Q
A
H
P
F
F
R
H
I
N
W
E
E
L
L
A
R
K
V
E
P
P
F
K
P
L
L
Q
S
------------------------------------------------------------------------------------------------------------
79
PsiBlast_CBE
46.96
39%
-89
- C1 -
4L46
1
KS6B1_HUMAN
A:
[20-300]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
L
L
R
V
L
G
K
G
G
Y
G
K
V
F
--
Q
V
---
R
K
VTGAN
T
G
----
K
I
F
A
M
K
V
L
K
K
A
M
I
V
R
N
A
-
K
---
D
T
A
H
T
K
A
E
R
N
I
-
L
E
E
-
V
-
K
H
P
---
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
E
G
--
I
--
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
K
G
-
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
H
Q
G
----
H
V
K
L
T
D
F
G
L
C
K
E
S
I
-
H
D
-----
H
T
F
C
----
G
T
I
E
Y
M
A
P
E
I
L
M
-
R
S
G
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
P
P
F
T
G
E
N
R
K
K
T
I
D
K
I
-
L
K
C
K
L
----
N
L
P
P
Y
---
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
R
L
G
A
-
G
-
P
G
D
A
G
E
V
Q
A
H
P
F
F
R
H
I
N
W
E
E
L
L
A
R
K
V
E
P
P
F
K
P
L
E
E
D
V
S
Q
F
D
S
K
F
T
R
Q
T
P
V
--
Q
V
F
L
G
F
T
Y
V
A
P
S
--------------------------------------------------------------------------------
85
PsiBlast_CBE
46.54
38%
-91
- C1 -
3G51
1
KS6A3_MOUSE
A:
[24-304]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
Q
F
E
L
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
V
K
----
K
I
-----
S
G
SDAR
Q
L
Y
A
M
K
V
L
K
K
A
T
L
-
K
V
R
-
D
-------------
I
-
L
V
E
-
V
-
N
H
P
---
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
----
E
V
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
S
L
G
-
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
G
----
H
I
K
L
T
D
F
G
L
S
K
E
S
I
-----------------
T
V
E
Y
M
A
P
E
V
V
N
-
R
R
G
H
T
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
T
L
P
F
Q
G
K
D
R
K
----
E
T
M
T
M
I
L
K
----
A
K
L
G
M
P
Q
F
L
S
P
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
R
L
G
A
G
P
-
D
G
V
E
E
-
I
K
R
H
S
F
F
S
T
I
D
W
N
K
L
Y
R
R
E
I
H
P
P
F
K
P
----------------------------------------------------------------------------------------------------------------
73
PsiBlast_CBE
46.53
39%
-86
- C1 -
4L44
1
KS6B1_HUMAN
A:
[20-300]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
L
L
R
V
L
G
K
G
G
Y
G
K
V
F
--
Q
V
---
R
K
VTGAN
T
G
----
K
I
F
A
M
K
V
L
K
K
A
M
I
V
R
N
A
-
K
---
D
T
A
H
T
K
A
E
R
N
I
-
L
E
E
-
V
-
K
H
P
---
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
E
G
--
I
--
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
K
G
-
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
H
Q
G
----
H
V
K
L
T
D
F
G
L
C
K
E
S
I
-
H
------
H
T
F
C
----
G
T
I
E
Y
M
A
P
E
I
L
M
-
R
S
G
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
P
P
F
T
G
E
N
R
K
K
T
I
D
K
I
-
L
K
C
K
L
----
N
L
P
P
Y
---
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
R
L
G
A
-
G
-
P
G
D
A
G
E
V
Q
A
H
P
F
F
R
H
I
N
W
E
E
L
L
A
R
K
V
E
P
P
F
K
P
L
L
Q
S
E
E
D
V
S
Q
D
S
K
F
T
R
Q
T
--
S
E
S
A
N
Q
V
F
L
G
F
A
Y
V
A
P
S
---------------------------------------------------------------------------
89
PsiBlast_CBE
46.41
38%
-87
- C1 -
4NUS
1
KS6A3_HUMAN
A:
[30-310]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
Q
F
E
L
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
V
K
----
K
I
-----
S
G
SDAR
Q
L
Y
A
M
K
V
L
K
K
A
T
L
-
K
V
R
-
D
---
R
V
R
T
K
M
-
E
R
D
I
-
L
V
E
-
V
-
N
H
P
---
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
----
E
V
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
S
L
G
-
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
G
----
H
I
K
L
T
D
F
G
L
S
K
E
S
I
-
D
H
E
K
-
K
A
Y
S
F
C
----
G
T
V
E
Y
M
A
P
E
V
V
N
-
R
R
G
H
T
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
T
L
P
F
Q
G
K
D
R
K
----
E
T
M
T
M
I
L
K
----
A
K
L
G
M
P
Q
F
L
S
P
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
R
L
G
A
G
P
-
D
G
V
E
E
-
I
K
R
H
S
F
F
S
T
I
D
W
N
K
L
Y
R
R
E
I
H
P
P
F
K
P
A
T
F
Y
F
D
P
---------------------------------------------------------------------------------------------------------
91
PsiBlast_CBE
46.40
38%
-95
- C1 -
5D9K
2
?
B:
[30-310]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
Q
F
E
L
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
V
K
----
K
I
-----
S
G
SDAR
Q
L
Y
A
M
K
V
L
K
K
A
T
L
-
K
V
R
-
D
---
R
V
R
T
K
M
-
E
R
D
I
-
L
V
E
-
V
-
N
H
P
---
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
----
E
V
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
S
L
G
-
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
G
----
H
I
K
L
T
D
F
G
L
S
K
E
-------------
C
----
G
T
V
E
Y
M
A
P
E
V
V
N
-
R
R
G
H
T
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
T
L
P
F
Q
G
K
D
R
K
----
E
T
M
T
M
I
L
K
----
A
K
L
G
M
P
Q
F
L
S
P
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
R
L
G
A
G
P
-
D
G
V
E
E
-
I
K
R
H
S
F
F
S
T
I
D
W
N
K
L
Y
R
R
E
I
H
P
P
F
K
P
T
F
Y
F
D
P
----------------------------------------------------------------------------------------------------------
86
PsiBlast_CBE
46.40
38%
-92
- C1 -
5D9L
2
?
A:
[30-310]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
Q
F
E
L
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
V
K
----
K
I
-----
S
G
SDAR
Q
L
Y
A
M
K
V
L
K
K
A
T
L
-
K
V
R
-
D
---
R
V
R
T
K
M
-
E
R
D
I
-
L
V
E
-
V
-
N
H
P
---
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
----
E
V
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
S
L
G
-
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
G
----
H
I
K
L
T
D
F
G
L
S
K
E
------------------
G
T
V
E
Y
M
A
P
E
V
V
N
-
R
R
G
H
T
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
T
L
P
F
Q
G
K
D
R
K
----
E
T
M
T
M
I
L
K
----
A
K
L
G
M
P
Q
F
L
S
P
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
R
L
G
A
G
P
-
D
G
V
E
E
-
I
K
R
H
S
F
F
S
T
I
D
W
N
K
L
Y
R
R
E
I
H
P
P
F
K
P
A
T
G
R
P
E
D
T
F
Y
F
D
P
---------------------------------------------------------------------------------------------------
92
PsiBlast_CBE
46.32
38%
-99
- C1 -
5D9K
2
?
A:
[30-310]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
Q
F
E
L
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
V
K
----
K
I
-----
S
G
SDAR
Q
L
Y
A
M
K
V
L
K
K
A
T
L
-
K
V
R
-
D
---
R
V
R
T
K
M
-
E
R
D
I
-
L
V
E
-
V
-
N
H
P
---
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
----
E
V
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
S
L
G
-
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
G
----
H
I
K
L
T
D
F
G
L
S
K
--------------
C
----
G
T
V
E
Y
M
A
P
E
V
V
N
-
R
R
G
H
T
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
T
L
P
F
Q
G
K
D
R
K
----
E
T
M
T
M
I
L
K
----
A
K
L
G
M
P
Q
F
L
S
P
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
R
L
G
A
G
P
-
D
G
V
E
E
-
I
K
R
H
S
F
F
S
T
I
D
W
N
K
L
Y
R
R
E
I
H
P
P
F
K
P
A
T
F
Y
F
D
P
---------------------------------------------------------------------------------------------------------
87
PsiBlast_CBE
45.83
38%
-83
- C1 -
4NW6
1
KS6A3_HUMAN
A:
[30-310]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
Q
F
E
L
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
V
K
----
K
I
-----
S
G
SDAR
Q
L
Y
A
M
K
V
L
K
K
A
T
L
-
K
V
R
-
D
---
R
V
R
T
K
M
-
E
R
D
I
-
L
V
E
-
V
-
N
H
P
---
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
----
E
V
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
S
L
G
-
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
G
----
H
I
K
L
T
D
F
G
L
S
K
E
S
I
-
D
H
E
K
-
K
A
Y
S
F
C
----
G
T
V
E
Y
M
A
P
E
V
V
N
-
R
R
G
H
T
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
T
L
P
F
Q
G
K
D
R
K
----
E
T
M
T
M
I
L
K
----
A
K
L
G
M
P
Q
F
L
S
P
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
R
L
G
A
G
P
-
D
G
V
E
E
-
I
K
R
H
S
F
F
S
T
I
D
W
N
K
L
Y
R
R
E
I
H
P
P
F
K
P
T
F
Y
F
D
P
----------------------------------------------------------------------------------------------------------
80
PsiBlast_CBE
45.80
39%
-96
- C1 -
3A61
1
KS6B1_HUMAN
A:
[19-299]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
L
L
R
V
L
G
K
G
G
Y
G
K
V
F
--
Q
V
---
R
K
V
T
GAN
T
G
----
K
I
F
A
M
K
V
L
K
-------------------
A
E
R
N
I
-
L
E
E
-
V
-
K
H
P
---
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
E
G
--
I
--
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
K
G
-
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
H
Q
G
----
H
V
K
L
T
D
F
G
----------------------
G
T
I
E
Y
M
A
P
E
I
L
M
-
R
S
G
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
P
P
F
T
G
E
N
R
K
K
T
I
D
K
I
-
L
K
C
K
L
----
N
L
P
P
Y
---
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
R
L
G
A
-
G
-
P
G
D
A
G
E
V
Q
A
H
P
F
F
R
H
I
N
W
E
E
L
L
A
R
K
V
E
P
P
F
K
P
----------------------------------------------------------------------------------------------------------------
96
PsiBlast_CBE
45.72
38%
-98
- C1 -
3HDN
1
SGK1_HUMAN
A:
[40-316]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
H
F
L
K
V
I
G
K
G
S
F
G
K
V
L
L
A
R
H
---
K
A
-----
E
E
----
V
F
Y
A
V
K
V
L
Q
K
K
A
I
-
L
-----------------
V
-
L
L
K
N
V
-
K
H
P
---
F
L
V
G
L
H
F
S
F
Q
T
A
D
K
L
Y
F
V
L
D
Y
I
N
G
G
E
L
F
Y
H
L
Q
R
----
E
R
C
F
L
E
P
R
A
R
F
Y
A
A
E
I
A
S
A
L
G
Y
L
H
S
L
N
-
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
S
Q
G
----
H
I
V
L
T
D
F
G
L
C
K
E
N
I
-
E
H
N
S
-
T
T
S
T
F
C
----
G
T
P
E
Y
L
A
P
E
V
L
H
-
K
Q
P
Y
D
R
T
V
D
W
W
C
L
G
A
V
L
Y
E
M
L
Y
G
L
P
P
F
--
Y
S
R
N
T
A
--
E
M
Y
D
N
I
L
N
----
K
P
L
Q
L
K
P
N
I
T
N
S
A
R
H
L
L
E
G
L
L
Q
K
D
R
T
K
R
L
G
A
K
D
-
D
F
M
E
--
I
K
S
H
V
F
F
S
L
I
N
W
D
D
L
I
N
K
K
I
T
P
P
F
N
P
----------------------------------------------------------------------------------------------------------------
140
HHSearch
45.68
38%
-88
- C1 -
3UBD
1
KS6A3_MOUSE
A:
[21-304]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
P
S
Q
F
E
L
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
V
K
K
---
I
S
GSD--
A
R
----
Q
L
Y
A
M
K
V
L
K
K
A
T
L
-
K
V
R
-----
D
R
V
------
D
I
-
L
V
E
-
V
-
N
H
P
---
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
----
E
V
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
S
L
G
-
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
G
----
H
I
K
L
T
D
F
G
L
S
K
------
E
K
-
K
A
Y
S
F
C
----
G
T
V
E
Y
M
A
P
E
V
V
N
-
R
R
G
H
T
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
T
L
P
F
Q
G
K
----
D
R
K
E
T
M
T
M
I
L
K
----
A
K
L
G
M
P
Q
F
L
S
P
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
R
L
G
A
G
P
-
D
G
V
E
E
-
I
K
R
H
S
F
F
S
T
I
D
W
N
K
L
Y
R
R
E
I
H
P
P
F
K
P
----------------------------------------------------------------------------------------------------------------
97
PsiBlast_CBE
45.66
38%
-93
- C1 -
3HDM
1
SGK1_HUMAN
A:
[40-317]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
H
F
L
K
V
I
G
K
G
S
F
G
K
V
L
L
A
R
H
---
K
A
-----
E
E
----
V
F
Y
A
V
K
V
L
Q
K
K
A
I
-
L
-----------------
V
-
L
L
K
N
V
-
K
H
P
---
F
L
V
G
L
H
F
S
F
Q
T
A
D
K
L
Y
F
V
L
D
Y
I
N
G
G
E
L
F
Y
H
L
Q
R
----
E
R
C
F
L
E
P
R
A
R
F
Y
A
A
E
I
A
S
A
L
G
Y
L
H
S
L
N
-
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
S
Q
G
----
H
I
V
L
T
D
F
G
L
C
K
E
N
I
-
E
H
N
S
-
T
T
S
T
F
C
----
G
T
P
E
Y
L
A
P
E
V
L
H
-
K
Q
P
Y
D
R
T
V
D
W
W
C
L
G
A
V
L
Y
E
M
L
Y
G
L
P
P
F
--
Y
S
R
N
T
A
--
E
M
Y
D
N
I
L
N
----
K
P
L
Q
L
K
P
N
I
T
N
S
A
R
H
L
L
E
G
L
L
Q
K
D
R
T
K
R
L
G
A
K
D
-
D
F
M
E
--
I
K
S
H
V
F
F
S
L
I
N
W
D
D
L
I
N
K
K
I
T
P
P
F
N
P
N
V
S
G
------------------------------------------------------------------------------------------------------------
88
PsiBlast_CBE
45.53
38%
-83
- C1 -
4NW5
1
KS6A3_HUMAN
A:
[30-310]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
Q
F
E
L
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
V
K
----
K
I
-----
S
G
SDAR
Q
L
Y
A
M
K
V
L
K
K
A
T
L
-
K
V
R
-
D
---
R
V
R
T
K
M
-
E
R
D
I
-
L
V
E
-
V
-
N
H
P
---
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
----
E
V
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
S
L
G
-
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
G
----
H
I
K
L
T
D
F
G
L
S
K
E
S
I
-
D
H
E
K
-
K
A
Y
S
F
C
----
G
T
V
E
Y
M
A
P
E
V
V
N
-
R
R
G
H
T
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
T
L
P
F
Q
G
K
D
R
K
----
E
T
M
T
M
I
L
K
----
A
K
L
G
M
P
Q
F
L
S
P
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
R
L
G
A
G
P
-
D
G
V
E
E
-
I
K
R
H
S
F
F
S
T
I
D
W
N
K
L
Y
R
R
E
I
H
P
P
F
K
P
T
F
Y
F
D
P
----------------------------------------------------------------------------------------------------------
78
PsiBlast_CBE
44.98
38%
-96
- C1 -
2Z7Q
1
KS6A1_HUMAN
A:
[30-308]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
L
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
V
R
K
---
V
T
RPD--
S
G
----
H
L
Y
A
M
K
V
L
------------------------
I
-
L
A
D
-
V
-
N
H
P
---
F
V
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
----
E
V
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
G
L
D
H
L
H
S
L
G
-
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
G
----
H
I
K
L
T
D
F
G
L
S
K
E
------------------
G
T
V
E
Y
M
A
P
E
V
V
N
-
R
Q
G
H
S
H
S
A
D
W
W
S
Y
G
V
L
M
F
E
M
L
T
G
S
L
P
F
Q
G
K
D
R
K
----
E
T
M
T
L
I
L
K
----
A
K
L
G
M
P
Q
F
L
S
T
E
A
Q
S
L
L
R
A
L
F
K
R
N
P
A
N
R
L
G
S
G
P
-
D
G
A
E
E
-
I
K
R
H
V
F
Y
S
T
I
D
W
N
K
L
Y
R
R
E
I
K
P
P
F
K
P
----------------------------------------------------------------------------------------------------------------
77
PsiBlast_CBE
44.69
38%
-90
- C1 -
2Z7R
1
KS6A1_HUMAN
A:
[30-308]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
L
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
V
R
K
---
V
T
RPD--
S
G
----
H
L
Y
A
M
K
V
L
K
K
A
T
L
-
K
V
----------------
I
-
L
A
D
-
V
-
N
H
P
---
F
V
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
----
E
V
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
G
L
D
H
L
H
S
L
G
-
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
G
----
H
I
K
L
T
D
F
G
L
S
K
E
------------------
G
T
V
E
Y
M
A
P
E
V
V
N
-
R
Q
G
H
S
H
S
A
D
W
W
S
Y
G
V
L
M
F
E
M
L
T
G
S
L
P
F
Q
G
K
D
R
K
----
E
T
M
T
L
I
L
K
----
A
K
L
G
M
P
Q
F
L
S
T
E
A
Q
S
L
L
R
A
L
F
K
R
N
P
A
N
R
L
G
S
G
P
-
D
G
A
E
E
-
I
K
R
H
V
F
Y
S
T
I
D
W
N
K
L
Y
R
R
E
I
K
P
P
F
K
P
----------------------------------------------------------------------------------------------------------------
95
PsiBlast_CBE
44.46
38%
-85
- C1 -
3UBD
1
KS6A3_MOUSE
A:
[24-304]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
Q
F
E
L
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
V
K
----
K
I
-----
S
G
SDAR
Q
L
Y
A
M
K
V
L
K
K
A
T
L
-
K
V
R
-
D
---
R
V
-------
D
I
-
L
V
E
-
V
-
N
H
P
---
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
----
E
V
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
S
L
G
-
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
G
----
H
I
K
L
T
D
F
G
L
S
K
E
------
K
-
K
A
Y
S
F
C
----
G
T
V
E
Y
M
A
P
E
V
V
N
-
R
R
G
H
T
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
T
L
P
F
Q
G
K
D
R
K
----
E
T
M
T
M
I
L
K
----
A
K
L
G
M
P
Q
F
L
S
P
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
R
L
G
A
G
P
-
D
G
V
E
E
-
I
K
R
H
S
F
F
S
T
I
D
W
N
K
L
Y
R
R
E
I
H
P
P
F
K
P
----------------------------------------------------------------------------------------------------------------
93
PsiBlast_CBE
43.81
38%
-82
- C1 -
4GUE
1
KS6A3_MOUSE
A:
[25-305]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
Q
F
E
L
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
V
K
----
K
I
-----
S
G
SDAR
Q
L
Y
A
M
K
V
L
K
K
A
T
L
-
K
V
R
-
D
---
R
V
----------
L
V
E
-
V
-
N
H
P
---
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
----
E
V
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
S
L
G
-
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
G
----
H
I
K
L
T
D
F
G
L
S
K
E
------
K
-
K
A
Y
S
F
C
----
G
T
V
E
Y
M
A
P
E
V
V
N
-
R
R
G
H
T
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
T
L
P
F
Q
G
K
D
R
K
----
E
T
M
T
M
I
L
K
----
A
K
L
G
M
P
Q
F
L
S
P
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
R
L
G
A
G
P
-
D
G
V
E
E
-
I
K
R
H
S
F
F
S
T
I
D
W
N
K
L
Y
R
R
E
I
H
P
P
F
K
P
----------------------------------------------------------------------------------------------------------------
94
PsiBlast_CBE
43.70
38%
-84
- C1 -
4EL9
1
KS6A3_MOUSE
A:
[25-305]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
Q
F
E
L
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
V
K
----
K
I
-----
S
G
SDAR
Q
L
Y
A
M
K
V
L
K
K
A
T
L
-
K
V
R
-
D
---
R
V
R
------
D
I
-
L
V
E
-
V
-
N
H
P
---
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
----
E
V
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
S
L
G
-
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
G
----
H
I
K
L
T
D
F
G
L
S
K
E
S----
E
K
-
K
A
Y
S
F
C
----
G
T
V
E
Y
M
A
P
E
V
V
N
-
R
R
G
H
T
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
T
L
P
F
Q
G
K
D
R
K
----
E
T
M
T
M
I
L
K
----
A
K
L
G
M
P
Q
F
L
S
P
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
R
L
G
A
G
P
-
D
G
V
E
E
-
I
K
R
H
S
F
F
S
T
I
D
W
N
K
L
Y
R
R
E
I
H
P
P
F
K
P
----------------------------------------------------------------------------------------------------------------
82
PsiBlast_CBE
43.48
39%
-91
- C1 -
3A60
1
KS6B1_HUMAN
A:
[19-299]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
L
L
R
V
L
G
K
G
G
Y
G
K
V
F
--
Q
V
---
R
K
V
T
GAN
T
G
----
K
I
F
A
M
K
V
L
K
K
A
M
---------------
K
A
E
R
N
I
-
L
E
E
-
V
-
K
H
P
---
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
E
G
--
I
--
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
K
G
-
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
H
Q
G
----
H
V
K
L
T
D
F
G
L
C
K
E
-------------------
T
I
E
Y
M
A
P
E
I
L
M
-
R
S
G
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
P
P
F
T
G
E
N
R
K
K
T
I
D
K
I
-
L
K
C
K
L
----
N
L
P
P
Y
---
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
R
L
G
A
-
G
-
P
G
D
A
G
E
V
Q
A
H
P
F
F
R
H
I
N
W
E
E
L
L
A
R
K
V
E
P
P
F
K
P
----------------------------------------------------------------------------------------------------------------
138
HHSearch
41.48
32%
-80
- C1 -
2Y0A
1
DAPK1_HUMAN
A:
[9-285]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
D
D
Y
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
---
K
S
-----
T
G
----
L
Q
Y
A
A
K
F
I
K
K
R
R
T
-
K
S
S
-
R
RGV
S
R
E
D
I
E
R
E
V
S
I
-
L
K
E
-
I
-
Q
H
P
---
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
----
K
E
S
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
-
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
VP
K
P
R
I
K
I
I
D
F
G
L
A
H
K
-
I
-
D
F
G
N
-
E
F
K
N
I
F
----
G
T
P
E
F
V
A
P
E
I
V
N
-
Y
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
----
T
K
Q
E
T
L
A
N
V
S
A
VNYE
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
------
T
I
Q
D
-
S
L
Q
H
P
W
I
K
P
K
D
T
Q
Q
A
L
S
R
K
A
S
A
V
N
M
E
K
F
K
K
F
A
A
R
--------------------------------------------------------------------------------------------------------
90
PsiBlast_CBE
41.20
39%
-98
- C1 -
4RLO
4
KS6B1_HUMAN
B:
[7-287]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
L
L
R
V
L
G
K
G
G
Y
G
K
V
F
--
Q
V
---
R
K
VTGAN
T
G
----
K
I
F
A
M
K
V
L
K
K
------------------------------
K
H
P
---
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
E
G
--
I
--
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
K
G
-
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
H
Q
G
----
H
V
K
L
T
D
F
G
L
C
K
E
S
I
-----------------
T
I
E
Y
M
A
P
E
I
L
M
-
R
S
G
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
P
P
F
T
G
E
N
R
K
K
T
I
D
K
I
-
L
K
C
K
L
----
N
L
P
P
Y
---
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
R
L
G
A
-
G
-
P
G
D
A
G
E
V
Q
A
H
P
F
F
R
H
I
N
W
E
E
L
L
A
R
K
V
E
P
P
F
K
P
L
---------------------------------------------------------------------------------------------------------------
81
PsiBlast_CBE
40.13
39%
-94
- C1 -
3A60
1
KS6B1_HUMAN
B:
[19-299]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
L
L
R
V
L
G
K
G
G
Y
G
K
V
F
--
Q
V
---
R
K
VTGAN
T
G
----
K
I
F
A
M
K
V
L
K
K
------------------------------
K
H
P
---
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
E
G
--
I
--
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
K
G
-
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
H
Q
G
----
H
V
K
L
T
D
F
G
L
C
K
E
S------------
C
----
G
T
I
E
Y
M
A
P
E
I
L
M
-
R
S
G
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
P
P
F
T
G
E
N
R
K
K
T
I
D
K
I
-
L
K
C
K
L
----
N
L
P
P
Y
---
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
R
L
G
A
-
G
-
P
G
D
A
G
E
V
Q
A
H
P
F
F
R
H
I
N
W
E
E
L
L
A
R
K
V
E
P
P
F
K
P
L
---------------------------------------------------------------------------------------------------------------