@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : GRK5_HUMAN: (2015-10-08 )
MELENIVANTVLLKAREGGGGKRKGKSKKWKEILKFPHISQCEDLRRTIDRDYCSLCDKQPIGRLLFRQFCETRPGLECYIQFLDSVAEYEVTPDEKLGEKGKEIMTKYLTPKSPVFIAQVGQDLVSQTEEKLLQKPCKELFSACAQSVHEYLRGEPFHEYLDSMFFDRFLQWKWLERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGRVGTVGYMAPEVLNNQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSEEAKSICKMLLTKDAKQRLGCQEEGAAEVKRHPFFRNMNFKRLEAGMLDPPFVPDPRAVYCKDVLDIEQFSTVKGVNLDHTDDDFYSKFSTGSVSIPWQNEMIETECFKELNVFGPNGTLPPDLNRNHPPEPPKKGLLQRLFKRQHQNNSKSSPSSKTSFNHHINSNHVSSNSTGSS
Atome Classification :
(75 SA)
.........10........20....---....30........40........50.....--...60........70-----........80........90-.--.......100.......110.......120.......130....-...-140.......150.......160.......170.......-180.......190.......200...---..-----..----210.......220-...-.-.--..230......-.240-..---.-.....250.......260.......270.......--280.......290.......300...-....310.......320.----......330...-.-...-340.....----...350......-.360.......370.......380.......390.......400.......410.......420.......430...-....440........450.......460.......470.......480..---.....490.......500.......510.......520.......530......-.540.......550.......560.......570.......580.......590
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
E
L
E
N
I
VAN
T
V
L
L
K
A
REGGGGKRKG---K
S
K
K
W
K
E
I
LKFPH
I
S
Q
C
E
D
L
R
R
T
I
D
R
D
Y
C
S
L--CDKQ
P
I
G
R
L
L
F
R
Q
F
C
-----ETRP
G
L
E
C
Y
I
Q
F
L
D
S
V
AEYE-V--T
P
D
E
K
L
G
E
K
G
K
E
I
M
T
K
YLTPKS
P
V
F
I
A
Q
V
G
Q
D
L
V
S
Q
T
E
E
K
L
L
Q
K
-
P
C
K
-
E
L
F
S
A
C
A
Q
S
V
H
E
Y
LRG
E
P
F
H
E
Y
L
D
S
M
F
F
D
R
F
L
Q
W
K
WLERQ-PV
T
K
N
T
F
R
Q
Y
R
V
LGKGGFG
E
V
C
A
C
Q
V
---RA-----T
G
----
K
M
Y
A
C
K
R
L
E
K
K
R
I
-
K
K
R-K-G--ESMAL
N
E
K
Q
I
L
-
E
K
-V-NS---
Q
-
F
V
V
N
L
A
Y
A
YETKD
A
L
C
L
V
L
T
IMNGG
D
L
K
F
H
I
Y
NMG--NPG
F
E
E
E
R
A
L
F
Y
A
A
E
I
L
C
G
L
E
D
L
H
RE-N
T
V
YRDLKPE
N
I
L
LDDYG----
H
I
R
I
SDL
G
L
A
V
K-I-PEG-
D
L
-IRGRV----GT
V
G
YM
A
P
E
V
LN-NQRYGLS
P
D
Y
W
G
L
G
C
L
I
Y
E
M
IEGQSPFR
G
R
K
E
K
V
K
R
E
E
V
D
R
R
V
L
E
T
E
E
V
Y
S
H
K
F
S
E
E
A
K
S
I
C
K
M
L
L
T
K
D
A
K
Q
RLGCQ-EE
G
A
A
E
-
V
K
RHPFFRNM
N
F
K
R
L
EAGMLDPPFVPDP
R
A
V
Y
C
K
D
V
L
D
I
E
Q
FS---TVKGVNLDHTD
D
D
F
Y
SKFSTG
S
V
SIPWQNEM
I
E
T
E
C
F
K
E
L
NVFGPNGTLPPDLN-RNHPPEP
P
K
K
G
L
L
Q
R
L
F
K
R
Q
HQNNSKSSPSSKTSFNHHINSNHVSSNSTGSS
3
PsiBlast_PDB
94.00
97%
-109
- C1 -
4WNK
1
GRK5_BOVIN
A:
[24-541]
-----------------------
K
G
---
K
S
K
K
W
K
E
I
L
K
F
P
H
I
N
Q
C
E
D
L
R
R
T
I
D
R
D
Y
C
S
L
--
C
D
K
Q
P
V
G
R
L
L
F
R
Q
F
C
-----
E
T
R
P
G
L
E
S
Y
I
Q
F
L
D
S
V
A
E
Y
E
-
V
--
T
P
D
E
K
L
G
E
K
G
K
E
I
M
T
K
Y
L
T
P
K
S
P
V
F
I
T
Q
V
G
R
D
L
V
S
Q
T
E
E
K
L
L
Q
K
-
P
C
K
-
E
L
F
S
A
C
V
Q
S
V
H
D
Y
L
R
G
E
P
F
H
E
Y
L
D
S
M
Y
F
D
R
F
L
Q
W
K
W
L
E
R
Q
-
P
V
T
K
N
T
F
R
Q
Y
R
V
L
G
K
G
G
F
G
E
V
C
A
C
Q
V
---
R
A
-----
T
G
----
K
M
Y
A
C
K
R
L
E
K
K
R
I
-
K
K
R
-
K
-
G
--
E
S
M
A
L
N
E
K
Q
I
L
-
E
K
-
V
-
N
S
---
R
-
F
V
V
N
L
A
Y
A
Y
E
T
K
D
A
L
C
L
V
L
T
I
M
N
G
G
D
L
K
F
H
I
Y
N
M
G
--
N
P
G
F
E
E
E
R
A
L
F
Y
A
A
E
I
L
C
G
L
E
D
L
H
H
E
-
N
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
D
Y
G
----
H
I
R
I
S
D
L
G
L
A
V
K
-
I
-
P
E
G
-
D
L
-
I
R
G
R
V
----
G
T
V
G
Y
M
A
P
E
V
L
N
-
N
Q
R
Y
G
L
S
P
D
Y
W
G
L
G
C
L
I
Y
E
M
I
E
G
Q
S
P
F
R
G
R
K
E
K
V
K
R
E
E
V
D
R
R
V
L
E
T
E
E
V
Y
S
H
K
F
S
E
E
A
K
S
I
C
K
M
L
L
T
K
D
A
K
Q
R
L
G
C
Q
-
E
E
G
A
A
E
-
V
K
R
H
P
F
F
R
N
M
N
F
K
R
L
E
A
G
M
L
D
P
P
F
V
P
D
P
R
A
V
Y
----------------------
H
T
D
D
D
F
Y
S
K
F
S
T
G
S
V
P
I
P
W
Q
S
E
M
I
E
T
E
C
F
K
E
L
N
V
F
G
P
H
G
T
L
S
P
D
L
N
-
R
S
H
-------------------------------------------------
1
PsiBlast_PDB
93.63
99%
-99
- C1 -
4TNB
1
GRK5_HUMAN
A:
[15-543]
--------------
A
R
E
G
G
G
G
K
R
K
G
---
K
S
K
K
W
K
E
I
L
K
F
P
H
I
S
Q
C
E
D
L
R
R
T
I
D
R
D
Y
C
S
L
--
C
D
K
Q
P
I
G
R
L
L
F
R
Q
F
C
-----
E
T
R
P
G
L
E
C
Y
I
Q
F
L
D
S
V
A
E
Y
E
-
V
--
T
P
D
E
K
L
G
E
K
G
K
K
I
M
T
K
Y
L
T
P
K
S
P
V
F
I
A
Q
V
G
Q
D
L
V
S
Q
T
E
E
K
L
L
Q
K
-
P
C
K
-
E
L
F
S
A
C
A
Q
S
V
H
E
Y
L
R
G
E
P
F
H
E
Y
L
D
S
M
F
F
D
R
F
L
Q
W
K
W
L
E
R
Q
-
P
V
T
K
N
T
F
R
Q
Y
R
V
L
G
K
G
G
F
G
E
V
C
A
C
Q
V
---
R
A
-----
T
G
----
K
M
Y
A
C
K
R
L
E
K
K
R
I
-
K
K
R
-
K
-
G
--
E
S
M
A
L
N
E
K
Q
I
L
-
E
K
-
V
-
N
S
---
Q
-
F
V
V
N
L
A
Y
A
Y
E
T
K
D
A
L
C
L
V
L
T
I
M
N
G
G
D
L
K
F
H
I
Y
N
M
G
--
N
P
G
F
E
E
E
R
A
L
F
Y
A
A
E
I
L
C
G
L
E
D
L
H
H
E
-
N
T
V
Y
R
D
L
K
P
E
N
I
L
L
D
D
Y
G
----
H
I
R
I
S
D
L
G
L
A
V
K
-
I
-
P
E
G
-
D
L
-
I
R
G
R
V
----
G
T
V
G
Y
M
A
P
E
V
L
N
-
N
Q
R
Y
G
L
S
P
D
Y
W
G
L
G
C
L
I
Y
E
M
I
E
G
Q
S
P
F
R
G
R
K
E
K
V
K
R
E
E
V
D
R
R
V
L
E
T
E
E
V
Y
S
H
K
F
S
E
E
A
K
S
I
C
K
M
L
L
T
K
D
A
K
Q
R
L
G
C
Q
-
E
E
E
A
A
E
-
V
K
R
H
P
F
F
R
N
M
N
F
K
R
L
E
A
G
M
L
D
P
P
F
V
P
D
P
R
A
V
Y
C
K
D
V
L
D
I
E
Q
F
S
---
T
V
K
G
V
N
L
D
H
T
D
D
D
F
Y
S
K
F
S
T
G
S
V
S
I
P
W
Q
N
E
M
I
E
T
E
C
F
K
E
L
N
V
F
G
P
N
G
T
L
P
P
D
L
N
-
R
N
H
P
P
-----------------------------------------------
2
PsiBlast_PDB
93.20
99%
-97
- C1 -
4TND
1
GRK5_HUMAN
A:
[15-543]
--------------
A
R
E
G
G
G
G
K
R
K
G
---
K
S
K
K
W
K
E
I
L
K
F
P
H
I
S
Q
C
E
D
L
R
R
T
I
D
R
D
Y
C
S
L
--
C
D
K
Q
P
I
G
R
L
L
F
R
Q
F
C
-----
E
T
R
P
G
L
E
C
Y
I
Q
F
L
D
S
V
A
E
Y
E
-
V
--
T
P
D
E
K
L
G
E
K
G
K
K
I
M
T
K
Y
L
T
P
K
S
P
V
F
I
A
Q
V
G
Q
D
L
V
S
Q
T
E
E
K
L
L
Q
K
-
P
C
K
-
E
L
F
S
A
C
A
Q
S
V
H
E
Y
L
R
G
E
P
F
H
E
Y
L
D
S
M
F
F
D
R
F
L
Q
W
K
W
L
E
R
Q
-
P
V
T
K
N
T
F
R
Q
Y
R
V
L
G
K
G
G
F
G
E
V
C
A
C
Q
V
---
R
A
-----
T
G
----
K
M
Y
A
C
K
R
L
E
K
K
R
I
-
K
K
R
-
K
-
G
--
E
S
M
A
L
N
E
K
Q
I
L
-
E
K
-
V
-
N
S
---
Q
-
F
V
V
N
L
A
Y
A
Y
E
T
K
D
A
L
C
L
V
L
T
I
M
N
G
G
D
L
K
F
H
I
Y
N
M
G
--
N
P
G
F
E
E
E
R
A
L
F
Y
A
A
E
I
L
C
G
L
E
D
L
H
H
E
-
N
T
V
Y
R
D
L
K
P
E
N
I
L
L
D
D
Y
G
----
H
I
R
I
S
D
L
G
L
A
V
K
-
I
-
P
E
G
-
D
L
-
I
R
G
R
V
----
G
T
V
G
Y
M
A
P
E
V
L
N
-
N
Q
R
Y
G
L
S
P
D
Y
W
G
L
G
C
L
I
Y
E
M
I
E
G
Q
S
P
F
R
G
R
K
E
K
V
K
R
E
E
V
D
R
R
V
L
E
T
E
E
V
Y
S
H
K
F
S
E
E
A
K
S
I
C
K
M
L
L
T
K
D
A
K
Q
R
L
G
C
Q
-
E
E
E
A
A
E
-
V
K
R
H
P
F
F
R
N
M
N
F
K
R
L
E
A
G
M
L
D
P
P
F
V
P
D
P
R
A
V
Y
C
K
D
V
L
D
I
E
Q
F
S
---
T
V
K
G
V
N
L
D
H
T
D
D
D
F
Y
S
K
F
S
T
G
S
V
S
I
P
W
Q
N
E
M
I
E
T
E
C
F
K
E
L
N
V
F
G
P
N
G
T
L
P
P
D
L
N
-
R
N
H
P
P
-----------------------------------------------
104
Fugue
84.75
69%
-101
- C1 -
2ACX
1
GRK6_HUMAN
A:
[14-532]
--------------------
K
A
R
K
G
---
K
S
K
K
W
R
Q
M
L
Q
F
P
H
I
S
Q
C
E
E
L
R
L
S
L
E
R
D
Y
H
S
L
--
C
E
R
N
P
I
G
R
L
L
F
R
E
F
C
-----
A
T
R
P
E
L
S
R
C
V
A
F
L
D
G
V
A
E
Y
E
-
V
--
T
P
D
D
K
R
K
A
C
G
R
N
L
T
Q
N
F
L
S
H
T
G
P
D
L
I
P
E
V
P
R
Q
L
V
T
N
C
T
Q
R
L
E
Q
G
-
P
C
K
-
D
L
F
Q
E
L
T
R
L
T
H
E
Y
L
S
V
A
P
F
A
D
Y
L
D
S
I
Y
F
N
R
F
L
Q
W
K
W
L
E
R
Q
-
P
V
T
K
N
T
F
R
Q
Y
R
V
L
G
K
G
G
F
G
E
V
C
A
C
Q
V
---
R
A
-----
T
G
----
K
M
Y
A
C
K
K
L
E
K
K
R
I
-
K
K
R
-
K
-
G
--
E
A
M
A
L
N
E
K
Q
I
L
-
E
K
-
V
-
N
S
---
R
-
F
V
V
S
L
A
Y
A
Y
E
T
K
D
A
L
C
L
V
L
T
L
M
N
G
G
D
L
K
F
H
I
Y
H
M
G
--
Q
A
G
F
P
E
A
R
A
V
F
Y
A
A
E
I
C
C
G
L
E
D
L
H
R
E
-
R
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
D
H
G
----
H
I
R
I
S
D
L
G
L
A
V
H
-
V
-
P
E
G
-
Q
T
-
I
K
G
R
V
----
G
T
V
G
Y
M
A
P
E
V
V
K
-
N
E
R
Y
T
F
S
P
D
W
W
A
L
G
C
L
L
Y
E
M
I
A
G
Q
S
P
F
Q
Q
R
K
K
K
I
K
R
E
E
V
E
R
L
V
K
E
V
P
E
E
Y
S
E
R
F
S
P
Q
A
R
S
L
C
S
Q
L
L
C
K
D
P
A
E
R
L
G
C
R
-
G
G
S
A
R
E
-
V
K
E
H
P
L
F
K
K
L
N
F
K
R
L
G
A
G
M
L
E
P
P
F
K
P
D
P
--------------------
Q
A
I
Y
C
E
P
T
D
Q
D
F
Y
Q
K
F
A
T
G
S
V
P
I
P
W
Q
N
E
M
V
E
T
E
C
F
Q
E
L
N
V
F
G
L
D
G
S
-----------------------------------------------------------
112
HHSearch
84.54
71%
-102
- C1 -
2ACX
1
GRK6_HUMAN
A:
[14-532]
-------------
K
A
R
-------
K
G
---
K
S
K
K
W
R
Q
M
L
Q
F
P
H
I
S
Q
C
E
E
L
R
L
S
L
E
R
D
Y
H
S
L
--
C
E
R
N
P
I
G
R
L
L
F
R
E
F
C
-----
A
T
R
P
E
L
S
R
C
V
A
F
L
D
G
V
A
E
Y
E
-
V
--
T
P
D
D
K
R
K
A
C
G
R
N
L
T
Q
N
F
L
S
H
T
G
P
D
L
I
P
E
V
P
R
Q
L
V
T
N
C
T
Q
R
L
E
Q
G
-
P
C
K
-
D
L
F
Q
E
L
T
R
L
T
H
E
Y
L
S
V
A
P
F
A
D
Y
L
D
S
I
Y
F
N
R
F
L
Q
W
K
W
L
E
R
Q
-
P
V
T
K
N
T
F
R
Q
Y
R
V
L
G
K
G
G
F
G
E
V
C
A
C
Q
V
---
R
A
-----
T
G
----
K
M
Y
A
C
K
K
L
E
K
K
R
I
-
K
K
R
-
K
-
G
--
E
A
M
A
L
N
E
K
Q
I
L
-
E
K
-
V
-
N
S
---
R
-
F
V
V
S
L
A
Y
A
Y
E
T
K
D
A
L
C
L
V
L
T
L
M
N
G
G
D
L
K
F
H
I
Y
H
M
G
--
Q
A
G
F
P
E
A
R
A
V
F
Y
A
A
E
I
C
C
G
L
E
D
L
H
R
E
-
R
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
D
H
G
----
H
I
R
I
S
D
L
G
L
A
V
H
-
V
-
P
E
G
-
Q
T
-
I
K
G
R
V
----
G
T
V
G
Y
M
A
P
E
V
V
K
-
N
E
R
Y
T
F
S
P
D
W
W
A
L
G
C
L
L
Y
E
M
I
A
G
Q
S
P
F
Q
Q
R
K
K
K
I
K
R
E
E
V
E
R
L
V
K
E
V
P
E
E
Y
S
E
R
F
S
P
Q
A
R
S
L
C
S
Q
L
L
C
K
D
P
A
E
R
L
G
C
R
-
G
G
S
A
R
E
-
V
K
E
H
P
L
F
K
K
L
N
F
K
R
L
G
A
G
M
L
E
P
P
F
K
P
D
P
Q
A
I
Y
C
--------------------
E
P
T
D
Q
D
F
Y
Q
K
F
A
T
G
S
V
P
I
P
W
Q
N
E
M
V
E
T
E
C
F
Q
E
L
N
V
F
G
L
D
G
S
-----------------------------------------------------------
4
PsiBlast_PDB
84.54
71%
-102
- C1 -
2ACX
1
GRK6_HUMAN
A:
[14-532]
-------------
K
A
R
-------
K
G
---
K
S
K
K
W
R
Q
M
L
Q
F
P
H
I
S
Q
C
E
E
L
R
L
S
L
E
R
D
Y
H
S
L
--
C
E
R
N
P
I
G
R
L
L
F
R
E
F
C
-----
A
T
R
P
E
L
S
R
C
V
A
F
L
D
G
V
A
E
Y
E
-
V
--
T
P
D
D
K
R
K
A
C
G
R
N
L
T
Q
N
F
L
S
H
T
G
P
D
L
I
P
E
V
P
R
Q
L
V
T
N
C
T
Q
R
L
E
Q
G
-
P
C
K
-
D
L
F
Q
E
L
T
R
L
T
H
E
Y
L
S
V
A
P
F
A
D
Y
L
D
S
I
Y
F
N
R
F
L
Q
W
K
W
L
E
R
Q
-
P
V
T
K
N
T
F
R
Q
Y
R
V
L
G
K
G
G
F
G
E
V
C
A
C
Q
V
---
R
A
-----
T
G
----
K
M
Y
A
C
K
K
L
E
K
K
R
I
-
K
K
R
-
K
-
G
--
E
A
M
A
L
N
E
K
Q
I
L
-
E
K
-
V
-
N
S
---
R
-
F
V
V
S
L
A
Y
A
Y
E
T
K
D
A
L
C
L
V
L
T
L
M
N
G
G
D
L
K
F
H
I
Y
H
M
G
--
Q
A
G
F
P
E
A
R
A
V
F
Y
A
A
E
I
C
C
G
L
E
D
L
H
R
E
-
R
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
D
H
G
----
H
I
R
I
S
D
L
G
L
A
V
H
-
V
-
P
E
G
-
Q
T
-
I
K
G
R
V
----
G
T
V
G
Y
M
A
P
E
V
V
K
-
N
E
R
Y
T
F
S
P
D
W
W
A
L
G
C
L
L
Y
E
M
I
A
G
Q
S
P
F
Q
Q
R
K
K
K
I
K
R
E
E
V
E
R
L
V
K
E
V
P
E
E
Y
S
E
R
F
S
P
Q
A
R
S
L
C
S
Q
L
L
C
K
D
P
A
E
R
L
G
C
R
-
G
G
S
A
R
E
-
V
K
E
H
P
L
F
K
K
L
N
F
K
R
L
G
A
G
M
L
E
P
P
F
K
P
D
P
Q
A
I
Y
C
--------------------
E
P
T
D
Q
D
F
Y
Q
K
F
A
T
G
S
V
P
I
P
W
Q
N
E
M
V
E
T
E
C
F
Q
E
L
N
V
F
G
L
D
G
S
-----------------------------------------------------------
24
PsiBlast_CBE
84.25
68%
-100
- C1 -
4YHJ
1
?
B:
[25-527]
------------------------
G
---
R
S
K
K
W
K
E
I
L
T
L
P
P
V
S
Q
C
S
E
L
R
H
S
I
E
K
D
Y
S
S
L
--
C
D
K
Q
P
I
G
R
R
L
F
R
Q
F
C
-----
D
T
K
P
T
L
K
R
H
I
E
F
L
D
A
V
A
E
Y
E
-
V
--
A
D
D
E
D
R
S
D
C
G
L
S
I
L
D
R
F
F
N
D
K
L
A
A
P
L
P
E
I
P
P
D
V
V
T
E
C
R
L
G
L
K
E
E
N
P
S
K
-
K
A
F
E
E
C
T
R
V
A
H
N
Y
L
R
G
E
P
F
E
E
Y
Q
E
S
S
Y
F
S
Q
F
L
Q
W
K
W
L
E
R
Q
-
P
V
T
K
N
T
F
R
H
Y
R
V
L
G
K
G
G
F
G
E
V
C
A
C
Q
V
---
R
A
-----
T
G
----
K
M
Y
A
C
K
K
L
Q
K
K
R
I
-
K
K
R
-
K
-
G
--
E
A
M
A
L
N
E
K
R
I
L
-
E
K
-
V
-
Q
S
---
R
-
F
V
V
S
L
A
Y
A
Y
E
T
K
D
A
L
C
L
V
L
T
I
M
N
G
G
D
L
K
F
H
I
Y
N
L
G
--
N
P
G
F
D
E
Q
R
A
V
F
Y
A
A
E
L
C
C
G
L
E
D
L
Q
R
E
-
R
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
D
R
G
----
H
I
R
I
S
D
L
G
L
A
T
E
-
I
-
P
E
G
-
Q
R
-
V
R
G
R
V
----
G
T
V
G
Y
M
A
P
E
V
V
N
-
N
E
K
Y
T
F
S
P
D
W
W
G
L
G
C
L
I
Y
E
M
I
Q
G
H
S
P
F
K
K
Y
K
E
K
V
K
W
E
E
V
D
Q
R
I
K
N
D
T
E
E
Y
S
E
K
F
S
E
D
A
K
S
I
C
R
M
L
L
T
K
N
P
S
K
R
L
G
C
R
-
G
E
G
A
A
G
-
V
K
Q
H
P
V
F
K
D
I
N
F
R
R
L
E
A
N
M
L
E
P
P
F
C
P
D
P
H
A
V
Y
C
----------------
G
I
Y
L
D
T
A
D
E
D
F
Y
A
R
F
A
T
G
C
V
S
I
P
W
Q
N
E
M
I
E
S
G
C
F
K
D
I
N
K
-----------------------------------------------------------------
21
PsiBlast_CBE
84.19
71%
-100
- C1 -
2ACX
1
GRK6_HUMAN
B:
[14-535]
-------------
K
A
R
-------
K
G
---
K
S
K
K
W
R
Q
M
L
Q
F
P
H
I
S
Q
C
E
E
L
R
L
S
L
E
R
D
Y
H
S
L
--
C
E
R
N
P
I
G
R
L
L
F
R
E
F
C
-----
A
T
R
P
E
L
S
R
C
V
A
F
L
D
G
V
A
E
Y
E
-
V
--
T
P
D
D
K
R
K
A
C
G
R
N
L
T
Q
N
F
L
S
H
T
G
P
D
L
I
P
E
V
P
R
Q
L
V
T
N
C
T
Q
R
L
E
Q
G
-
P
C
K
-
D
L
F
Q
E
L
T
R
L
T
H
E
Y
L
S
V
A
P
F
A
D
Y
L
D
S
I
Y
F
N
R
F
L
Q
W
K
W
L
E
R
Q
-
P
V
T
K
N
T
F
R
Q
Y
R
V
L
G
K
G
G
F
G
E
V
C
A
C
Q
V
---
R
A
-----
T
G
----
K
M
Y
A
C
K
K
L
E
K
K
R
I
-
K
K
R
-
K
-
G
--
E
A
M
A
L
N
E
K
Q
I
L
-
E
K
-
V
-
N
S
---
R
-
F
V
V
S
L
A
Y
A
Y
E
T
K
D
A
L
C
L
V
L
T
L
M
N
G
G
D
L
K
F
H
I
Y
H
M
----
A
G
F
P
E
A
R
A
V
F
Y
A
A
E
I
C
C
G
L
E
D
L
H
R
E
-
R
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
D
H
G
----
H
I
R
I
S
D
L
G
L
A
V
H
-
V
-
P
E
G
-
Q
T
-
I
K
G
R
V
----
G
T
V
G
Y
M
A
P
E
V
V
K
-
N
E
R
Y
T
F
S
P
D
W
W
A
L
G
C
L
L
Y
E
M
I
A
G
Q
S
P
F
Q
Q
---
K
I
K
R
E
E
V
E
R
L
V
K
E
V
P
E
E
Y
S
E
R
F
S
P
Q
A
R
S
L
C
S
Q
L
L
C
K
D
P
A
E
R
L
G
C
R
-
G
G
S
A
R
E
-
V
K
E
H
P
L
F
K
K
L
N
F
K
R
L
G
A
G
M
L
E
P
P
F
K
P
D
P
Q
A
I
Y
---------------------
E
P
T
D
Q
D
F
Y
Q
K
F
A
T
G
S
V
P
I
P
W
Q
N
E
M
V
E
T
E
C
F
Q
E
L
N
V
F
G
L
D
G
S
V
P
P
--------------------------------------------------------
7
PsiBlast_PDB
82.70
68%
-102
- C1 -
4YHJ
1
?
A:
[25-525]
------------------------
G
---
R
S
K
K
W
K
E
I
L
T
L
P
P
V
S
Q
C
S
E
L
R
H
S
I
E
K
D
Y
S
S
L
--
C
D
K
Q
P
I
G
R
R
L
F
R
Q
F
C
-----
D
T
K
P
T
L
K
R
H
I
E
F
L
D
A
V
A
E
Y
E
-
V
--
A
D
D
E
D
R
S
D
C
G
L
S
I
L
D
R
F
F
N
D
K
L
A
A
P
L
P
E
I
P
P
D
V
V
T
E
C
R
L
G
L
K
E
E
N
P
S
K
-
K
A
F
E
E
C
T
R
V
A
H
N
Y
L
R
G
E
P
F
E
E
Y
Q
E
S
S
Y
F
S
Q
F
L
Q
W
K
W
L
E
R
Q
-
P
V
T
K
N
T
F
R
H
Y
R
V
L
G
K
G
G
F
G
E
V
C
A
C
Q
V
---
R
A
-----
T
G
----
K
M
Y
A
C
K
K
L
Q
K
K
R
I
-
K
K
R
-
K
-
G
--
E
A
M
A
L
N
E
K
R
I
L
-
E
K
-
V
-
Q
S
---
R
-
F
V
V
S
L
A
Y
A
Y
E
T
K
D
A
L
C
L
V
L
T
I
M
N
G
G
D
L
K
F
H
I
Y
N
L
G
--
N
P
G
F
D
E
Q
R
A
V
F
Y
A
A
E
L
C
C
G
L
E
D
L
Q
R
E
-
R
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
D
R
G
----
H
I
R
I
S
D
L
G
L
A
T
E
-
I
-
P
E
G
-
Q
R
-
V
R
G
R
V
----
G
T
V
G
Y
M
A
P
E
V
V
N
-
N
E
K
Y
T
F
S
P
D
W
W
G
L
G
C
L
I
Y
E
M
I
Q
G
H
S
P
F
K
K
Y
K
E
K
V
K
W
E
E
V
D
Q
R
I
K
N
D
T
E
E
Y
S
E
K
F
S
E
D
A
K
S
I
C
R
M
L
L
T
K
N
P
S
K
R
L
G
C
R
-
G
E
G
A
A
G
-
V
K
Q
H
P
V
F
K
D
I
N
F
R
R
L
E
A
N
M
L
E
P
P
F
C
P
D
P
H
A
V
Y
C
K
D
V
L
D
I
E
Q
F
S
---
V
V
K
G
I
Y
L
D
T
A
D
E
D
F
Y
A
R
F
A
T
G
C
V
S
I
P
W
Q
N
E
M
I
E
S
G
C
F
K
D
I
-------------------------------------------------------------------
30
PsiBlast_CBE
79.62
47%
-94
- C1 -
3C4W
1
RK_BOVIN
B:
[9-533]
-----
V
V
A
N
S
A
F
I
A
A
R
-
G
S
F
D
A
S
S
G
PAS
R
D
R
K
Y
L
A
R
L
K
L
P
P
L
S
K
C
E
A
L
R
E
S
L
D
L
G
F
E
G
M
--
C
L
E
Q
P
I
G
K
R
L
F
Q
Q
F
L
-----
R
T
H
E
Q
H
G
P
A
L
Q
L
W
K
D
I
E
D
Y
D
-
T
--
A
D
D
A
L
R
P
Q
K
A
Q
A
L
R
A
A
Y
L
E
P
Q
A
Q
L
F
C
S
F
L
D
A
E
T
V
A
R
A
R
A
G
-------
D
-
G
L
F
Q
P
L
L
R
A
V
L
A
H
L
G
Q
A
P
F
Q
E
F
L
D
S
L
Y
F
L
R
F
L
Q
W
K
W
L
E
A
Q
-
P
M
G
E
D
W
F
L
D
F
R
V
L
G
R
G
G
F
G
E
V
F
A
C
Q
M
---
K
A
-----
T
G
----
K
L
Y
A
C
K
K
L
N
K
K
R
L
-
K
K
R
-
K
-
G
--
Y
Q
G
A
M
V
E
K
K
I
L
-
A
K
-
V
-
H
S
---
R
-
F
I
V
S
L
A
Y
A
F
E
T
K
T
D
L
C
L
V
M
T
I
M
N
G
G
D
I
R
Y
H
I
Y
N
V
D
ED
N
P
G
F
Q
E
P
R
A
I
F
Y
T
A
Q
I
V
S
G
L
E
H
L
H
Q
R
-
N
I
I
Y
R
D
L
K
P
E
N
V
L
L
D
D
D
G
----
N
V
R
I
S
D
L
G
L
A
V
E
-
L
-
K
A
G
-
Q
T
K
T
K
G
Y
A
----
G
T
P
G
F
M
A
P
E
L
L
L
-
G
E
E
Y
D
F
S
V
D
Y
F
A
L
G
V
T
L
Y
E
M
I
A
A
R
G
P
F
R
A
R
G
E
K
V
E
N
K
E
L
K
Q
R
V
L
E
Q
A
V
T
Y
P
D
K
F
S
P
A
S
K
D
F
C
E
A
L
L
Q
K
D
P
E
K
R
L
G
F
R
-
D
G
S
C
D
G
-
L
R
T
H
P
L
F
R
D
I
S
W
R
Q
L
E
A
G
M
L
T
P
P
F
V
P
D
S
R
T
V
Y
A
K
N
-----------
T
V
K
G
V
A
F
E
K
A
D
T
E
F
F
Q
E
F
A
S
G
T
C
P
I
P
W
Q
E
E
M
I
E
T
G
V
F
G
D
L
N
V
W
R
P
--------------------------------------------------------------
25
PsiBlast_CBE
79.43
47%
-97
- C1 -
3C50
1
RK_BOVIN
B:
[30-533]
-------------------------S--
R
D
R
K
Y
L
A
R
L
K
L
P
P
L
S
K
C
E
A
L
R
E
S
L
D
L
G
F
E
G
M
--
C
L
E
Q
P
I
G
K
R
L
F
Q
Q
F
L
-----
R
T
H
E
Q
H
G
P
A
L
Q
L
W
K
D
I
E
D
Y
D
-
T
--
A
D
D
A
L
R
P
Q
K
A
Q
A
L
R
A
A
Y
L
E
P
Q
A
Q
L
F
C
S
F
L
D
A
E
T
V
A
R
A
R
A
G
-----
A
G
D
-
G
L
F
Q
P
L
L
R
A
V
L
A
H
L
G
Q
A
P
F
Q
E
F
L
D
S
L
Y
F
L
R
F
L
Q
W
K
W
L
E
A
Q
-
P
M
G
E
D
W
F
L
D
F
R
V
L
G
R
G
G
F
G
E
V
F
A
C
Q
M
---
K
A
-----
T
G
----
K
L
Y
A
C
K
K
L
N
K
K
R
L
-
K
K
R
-
K
-
G
--
Y
Q
G
A
M
V
E
K
K
I
L
-
A
K
-
V
-
H
S
---
R
-
F
I
V
S
L
A
Y
A
F
E
T
K
T
D
L
C
L
V
M
T
I
M
N
G
G
D
I
R
Y
H
I
Y
N
V
D
ED
N
P
G
F
Q
E
P
R
A
I
F
Y
T
A
Q
I
V
S
G
L
E
H
L
H
Q
R
-
N
I
I
Y
R
D
L
K
P
E
N
V
L
L
D
D
D
G
----
N
V
R
I
S
D
L
G
L
A
V
E
-
L
-
K
A
G
-
Q
T
K
T
K
G
Y
A
----
G
T
P
G
F
M
A
P
E
L
L
L
-
G
E
E
Y
D
F
S
V
D
Y
F
A
L
G
V
T
L
Y
E
M
I
A
A
R
G
P
F
R
A
R
G
E
K
V
E
N
K
E
L
K
Q
R
V
L
E
Q
A
V
T
Y
P
D
K
F
S
P
A
S
K
D
F
C
E
A
L
L
Q
K
D
P
E
K
R
L
G
F
R
-
D
G
S
C
D
G
-
L
R
T
H
P
L
F
R
D
I
S
W
R
Q
L
E
A
G
M
L
T
P
P
F
V
P
D
S
R
T
V
Y
A
--------
F
S
---
T
V
K
G
V
A
F
E
K
A
D
T
E
F
F
Q
E
F
A
S
G
T
C
P
I
P
W
Q
E
E
M
I
E
T
G
V
F
G
D
L
N
V
W
R
P
--------------------------------------------------------------
26
PsiBlast_CBE
79.28
47%
-102
- C1 -
3C4X
1
RK_BOVIN
B:
[31-533]
----------------------------
R
D
R
K
Y
L
A
R
L
K
L
P
P
L
S
K
C
E
A
L
R
E
S
L
D
L
G
F
E
G
M
--
C
L
E
Q
P
I
G
K
R
L
F
Q
Q
F
L
-----
R
T
H
E
Q
H
G
P
A
L
Q
L
W
K
D
I
E
D
Y
D
-
T
--
A
D
D
A
L
R
P
Q
K
A
Q
A
L
R
A
A
Y
L
E
P
Q
A
Q
L
F
C
S
F
L
D
A
E
T
V
A
R
A
--------------
F
Q
P
L
L
R
A
V
L
A
H
L
G
Q
A
P
F
Q
E
F
L
D
S
L
Y
F
L
R
F
L
Q
W
K
W
L
E
A
Q
-
P
M
G
E
D
W
F
L
D
F
R
V
L
G
R
G
G
F
G
E
V
F
A
C
Q
M
---
K
A
-----
T
G
----
K
L
Y
A
C
K
K
L
N
K
K
R
L
-
K
K
R
-
K
-
G
--
Y
Q
G
A
M
V
E
K
K
I
L
-
A
K
-
V
-
H
S
---
R
-
F
I
V
S
L
A
Y
A
F
E
T
K
T
D
L
C
L
V
M
T
I
M
N
G
G
D
I
R
Y
H
I
Y
N
V
D
ED
N
P
G
F
Q
E
P
R
A
I
F
Y
T
A
Q
I
V
S
G
L
E
H
L
H
Q
R
-
N
I
I
Y
R
D
L
K
P
E
N
V
L
L
D
D
D
G
----
N
V
R
I
S
D
L
G
L
A
V
E
-
L
-
K
A
G
-
Q
T
K
T
K
G
Y
A
----
G
T
P
G
F
M
A
P
E
L
L
L
-
G
E
E
Y
D
F
S
V
D
Y
F
A
L
G
V
T
L
Y
E
M
I
A
A
R
G
P
F
R
A
R
G
E
K
V
E
N
K
E
L
K
Q
R
V
L
E
Q
A
V
T
Y
P
D
K
F
S
P
A
S
K
D
F
C
E
A
L
L
Q
K
D
P
E
K
R
L
G
F
R
-
D
G
S
C
D
G
-
L
R
T
H
P
L
F
R
D
I
S
W
R
Q
L
E
A
G
M
L
T
P
P
F
V
P
D
S
R
T
-----------------------
E
K
A
D
T
E
F
F
Q
E
F
A
S
G
T
C
P
I
P
W
Q
E
E
M
I
E
T
G
V
F
G
D
L
N
V
W
R
P
--------------------------------------------------------------
14
PsiBlast_PDB
78.73
48%
-97
- C1 -
4L9I
2
RK_BOVIN
A:
[2-504]
----------------------------
R
D
R
K
Y
L
A
R
L
K
L
P
P
L
S
K
C
E
A
L
R
E
S
L
D
L
G
F
E
G
M
--
C
L
E
Q
P
I
G
K
R
L
F
Q
Q
F
L
-----
R
T
H
E
Q
H
G
P
A
L
Q
L
W
K
D
I
E
D
Y
D
-
T
--
A
D
D
A
L
R
P
Q
K
A
Q
A
L
R
A
A
Y
L
E
P
Q
A
Q
L
F
C
S
F
L
D
A
E
T
V
A
R
A
R
A
G
-----
A
G
D
-
G
L
F
Q
P
L
L
R
A
V
L
A
H
L
G
Q
A
P
F
Q
E
F
L
D
S
L
Y
F
L
R
F
L
Q
W
K
W
L
E
A
Q
-
P
M
G
E
D
W
F
L
D
F
R
V
L
G
R
G
G
F
G
E
V
F
A
C
Q
M
---
K
A
-----
T
G
----
K
L
Y
A
C
K
K
L
N
K
K
R
L
-
K
K
R
-
K
-
G
--
Y
Q
G
A
M
V
E
K
K
I
L
-
A
K
-
V
-
H
S
---
R
-
F
I
V
S
L
A
Y
A
F
E
T
K
T
D
L
C
L
V
M
T
I
M
N
G
G
D
I
R
Y
H
I
Y
N
V
D
ED
N
P
G
F
Q
E
P
R
A
I
F
Y
T
A
Q
I
V
S
G
L
E
H
L
H
Q
R
-
N
I
I
Y
R
D
L
K
P
E
N
V
L
L
D
D
D
G
----
N
V
R
I
S
D
L
G
L
A
V
E
-
L
-
K
A
G
-
Q
T
K
T
K
G
Y
A
----
G
T
P
G
F
M
A
P
E
L
L
L
-
G
E
E
Y
D
F
S
V
D
Y
F
A
L
G
V
T
L
Y
E
M
I
A
A
R
G
P
F
R
A
R
G
E
K
V
E
N
K
E
L
K
Q
R
V
L
E
Q
A
V
T
Y
P
D
K
F
S
P
A
S
K
D
F
C
E
A
L
L
Q
K
D
P
E
K
R
L
G
F
R
-
D
G
S
C
D
G
-
L
R
T
H
P
L
F
R
D
I
S
W
R
Q
L
E
A
G
M
L
T
P
P
F
V
P
D
S
R
T
V
Y
A
K
N
I
Q
D
V
G
A
F
S
---
T
V
K
G
V
A
F
E
K
A
D
T
E
F
F
Q
E
F
A
S
G
T
C
P
I
P
W
Q
E
E
M
I
E
T
G
V
F
G
D
L
N
V
W
R
P
--------------------------------------------------------------
105
Fugue
78.18
48%
-98
- C1 -
3C4Z
1
RK_BOVIN
A:
[31-533]
----------------------------
R
D
R
K
Y
L
A
R
L
K
L
P
P
L
S
K
C
E
A
L
R
E
S
L
D
L
G
F
E
G
M
--
C
L
E
Q
P
I
G
K
R
L
F
Q
Q
F
L
-----
R
T
H
E
Q
H
G
P
A
L
Q
L
W
K
D
I
E
D
Y
D
-
T
--
A
D
D
A
L
R
P
Q
K
A
Q
A
L
R
A
A
Y
L
E
P
Q
A
Q
L
F
C
S
F
L
D
A
E
T
V
A
R
A
R
A
G
---------
G
L
F
Q
P
L
L
R
A
V
L
A
H
L
G
Q
A
P
F
Q
E
F
L
D
S
L
Y
F
L
R
F
L
Q
W
K
W
L
E
A
Q
-
P
M
G
E
D
W
F
L
D
F
R
V
L
G
R
G
G
F
G
E
V
F
A
C
Q
M
---
K
A
-----
T
G
----
K
L
Y
A
C
K
K
L
N
K
K
R
L
-
K
K
R
-
K
-
G
--
Y
Q
G
A
M
V
E
K
K
I
L
-
A
K
-
V
-
H
S
---
R
-
F
I
V
S
L
A
Y
A
F
E
T
K
T
D
L
C
L
V
M
T
I
M
N
G
G
D
I
R
Y
H
I
Y
N
V
D
ED
N
P
G
F
Q
E
P
R
A
I
F
Y
T
A
Q
I
V
S
G
L
E
H
L
H
Q
R
-
N
I
I
Y
R
D
L
K
P
E
N
V
L
L
D
D
D
G
----
N
V
R
I
S
D
L
G
L
A
V
E
-
L
-
K
A
G
Q
T
K
-
T
K
G
Y
A
----
G
T
P
G
F
M
A
P
E
L
L
L
-
G
E
E
Y
D
F
S
V
D
Y
F
A
L
G
V
T
L
Y
E
M
I
A
A
R
G
P
F
R
A
R
G
E
K
V
E
N
K
E
L
K
Q
R
V
L
E
Q
A
V
T
Y
P
D
K
F
S
P
A
S
K
D
F
C
E
A
L
L
Q
K
D
P
E
K
R
L
G
F
R
-
D
G
S
C
D
G
-
L
R
T
H
P
L
F
R
D
I
S
W
R
Q
L
E
A
G
M
L
T
P
P
F
V
P
D
S
R
T
V
Y
A
K
N
-------
G
---
A
F
S
G
V
A
F
E
K
A
D
T
E
F
F
Q
E
F
A
S
G
T
C
P
I
P
W
Q
E
E
M
I
E
T
G
V
F
G
D
L
N
V
W
R
P
--------------------------------------------------------------
10
PsiBlast_PDB
78.14
47%
-98
- C1 -
3C4Z
1
RK_BOVIN
A:
[31-533]
----------------------------
R
D
R
K
Y
L
A
R
L
K
L
P
P
L
S
K
C
E
A
L
R
E
S
L
D
L
G
F
E
G
M
--
C
L
E
Q
P
I
G
K
R
L
F
Q
Q
F
L
-----
R
T
H
E
Q
H
G
P
A
L
Q
L
W
K
D
I
E
D
Y
D
-
T
--
A
D
D
A
L
R
P
Q
K
A
Q
A
L
R
A
A
Y
L
E
P
Q
A
Q
L
F
C
S
F
L
D
A
E
T
V
A
R
A
R
A
G
---------
G
L
F
Q
P
L
L
R
A
V
L
A
H
L
G
Q
A
P
F
Q
E
F
L
D
S
L
Y
F
L
R
F
L
Q
W
K
W
L
E
A
Q
-
P
M
G
E
D
W
F
L
D
F
R
V
L
G
R
G
G
F
G
E
V
F
A
C
Q
M
---
K
A
-----
T
G
----
K
L
Y
A
C
K
K
L
N
K
K
R
L
-
K
K
R
-
K
-
G
--
Y
Q
G
A
M
V
E
K
K
I
L
-
A
K
-
V
-
H
S
---
R
-
F
I
V
S
L
A
Y
A
F
E
T
K
T
D
L
C
L
V
M
T
I
M
N
G
G
D
I
R
Y
H
I
Y
N
V
D
ED
N
P
G
F
Q
E
P
R
A
I
F
Y
T
A
Q
I
V
S
G
L
E
H
L
H
Q
R
-
N
I
I
Y
R
D
L
K
P
E
N
V
L
L
D
D
D
G
----
N
V
R
I
S
D
L
G
L
A
V
E
-
L
-
K
A
G
-
Q
T
K
T
K
G
Y
A
----
G
T
P
G
F
M
A
P
E
L
L
L
-
G
E
E
Y
D
F
S
V
D
Y
F
A
L
G
V
T
L
Y
E
M
I
A
A
R
G
P
F
R
A
R
G
E
K
V
E
N
K
E
L
K
Q
R
V
L
E
Q
A
V
T
Y
P
D
K
F
S
P
A
S
K
D
F
C
E
A
L
L
Q
K
D
P
E
K
R
L
G
F
R
-
D
G
S
C
D
G
-
L
R
T
H
P
L
F
R
D
I
S
W
R
Q
L
E
A
G
M
L
T
P
P
F
V
P
D
S
R
T
V
Y
A
K
N
----
G
A
F
S
------
G
V
A
F
E
K
A
D
T
E
F
F
Q
E
F
A
S
G
T
C
P
I
P
W
Q
E
E
M
I
E
T
G
V
F
G
D
L
N
V
W
R
P
--------------------------------------------------------------
8
PsiBlast_PDB
78.11
47%
-95
- C1 -
3C4X
1
RK_BOVIN
A:
[30-533]
-------------------------S--
R
D
R
K
Y
L
A
R
L
K
L
P
P
L
S
K
C
E
A
L
R
E
S
L
D
L
G
F
E
G
M
--
C
L
E
Q
P
I
G
K
R
L
F
Q
Q
F
L
-----
R
T
H
E
Q
H
G
P
A
L
Q
L
W
K
D
I
E
D
Y
D
-
T
--
A
D
D
A
L
R
P
Q
K
A
Q
A
L
R
A
A
Y
L
E
P
Q
A
Q
L
F
C
S
F
L
D
A
E
T
V
A
R
A
R
A
G
-----
A
G
D
-
G
L
F
Q
P
L
L
R
A
V
L
A
H
L
G
Q
A
P
F
Q
E
F
L
D
S
L
Y
F
L
R
F
L
Q
W
K
W
L
E
A
Q
-
P
M
G
E
D
W
F
L
D
F
R
V
L
G
R
G
G
F
G
E
V
F
A
C
Q
M
---
K
A
-----
T
G
----
K
L
Y
A
C
K
K
L
N
K
K
R
L
-
K
K
R
-
K
-
G
--
Y
Q
G
A
M
V
E
K
K
I
L
-
A
K
-
V
-
H
S
---
R
-
F
I
V
S
L
A
Y
A
F
E
T
K
T
D
L
C
L
V
M
T
I
M
N
G
G
D
I
R
Y
H
I
Y
N
V
D
ED
N
P
G
F
Q
E
P
R
A
I
F
Y
T
A
Q
I
V
S
G
L
E
H
L
H
Q
R
-
N
I
I
Y
R
D
L
K
P
E
N
V
L
L
D
D
D
G
----
N
V
R
I
S
D
L
G
L
A
V
E
-
L
-
K
A
G
-
Q
T
K
T
K
G
Y
A
----
G
T
P
G
F
M
A
P
E
L
L
L
-
G
E
E
Y
D
F
S
V
D
Y
F
A
L
G
V
T
L
Y
E
M
I
A
A
R
G
P
F
R
A
R
G
E
K
V
E
N
K
E
L
K
Q
R
V
L
E
Q
A
V
T
Y
P
D
K
F
S
P
A
S
K
D
F
C
E
A
L
L
Q
K
D
P
E
K
R
L
G
F
R
-
D
G
S
C
D
G
-
L
R
T
H
P
L
F
R
D
I
S
W
R
Q
L
E
A
G
M
L
T
P
P
F
V
P
D
--------
I
Q
D
V
G
A
F
S
---
T
V
K
G
V
A
F
E
K
A
D
T
E
F
F
Q
E
F
A
S
G
T
C
P
I
P
W
Q
E
E
M
I
E
T
G
V
F
G
D
L
N
V
W
R
P
--------------------------------------------------------------
113
HHSearch
77.82
48%
-99
- C1 -
3C4Z
1
RK_BOVIN
A:
[31-533]
----------------------------
R
D
R
K
Y
L
A
R
L
K
L
P
P
L
S
K
C
E
A
L
R
E
S
L
D
L
G
F
E
G
M
--
C
L
E
Q
P
I
G
K
R
L
F
Q
Q
F
L
-----
R
T
H
E
Q
H
G
P
A
L
Q
L
W
K
D
I
E
D
Y
D
-
T
--
A
D
D
A
L
R
P
Q
K
A
Q
A
L
R
A
A
Y
L
E
P
Q
A
Q
L
F
C
S
F
L
D
A
E
T
V
A
R
A
R
A
----
G
-----
G
L
F
Q
P
L
L
R
A
V
L
A
H
L
G
Q
A
P
F
Q
E
F
L
D
S
L
Y
F
L
R
F
L
Q
W
K
W
L
E
A
Q
-
P
M
G
E
D
W
F
L
D
F
R
V
L
G
R
G
G
F
G
E
V
F
A
C
Q
M
---
K
A
-----
T
G
----
K
L
Y
A
C
K
K
L
N
K
K
R
L
-
K
K
R
-
K
-
G
--
Y
Q
G
A
M
V
E
K
K
I
L
-
A
K
-
V
-
H
S
---
R
-
F
I
V
S
L
A
Y
A
F
E
T
K
T
D
L
C
L
V
M
T
I
M
N
G
G
D
I
R
Y
H
I
Y
N
V
D
ED
N
P
G
F
Q
E
P
R
A
I
F
Y
T
A
Q
I
V
S
G
L
E
H
L
H
Q
R
-
N
I
I
Y
R
D
L
K
P
E
N
V
L
L
D
D
D
G
----
N
V
R
I
S
D
L
G
L
A
V
E
-
L
K
A
G
Q
-
T
K
-
T
K
G
Y
A
----
G
T
P
G
F
M
A
P
E
L
L
L
-
G
E
E
Y
D
F
S
V
D
Y
F
A
L
G
V
T
L
Y
E
M
I
A
A
R
G
P
F
R
A
R
G
E
K
V
E
N
K
E
L
K
Q
R
V
L
E
Q
A
V
T
Y
P
D
K
F
S
P
A
S
K
D
F
C
E
A
L
L
Q
K
D
P
E
K
R
L
G
F
R
-
D
G
S
C
D
G
-
L
R
T
H
P
L
F
R
D
I
S
W
R
Q
L
E
A
G
M
L
T
P
P
F
V
P
D
S
R
T
V
Y
A
K
N
----
G
A
F
S
------
G
V
A
F
E
K
A
D
T
E
F
F
Q
E
F
A
S
G
T
C
P
I
P
W
Q
E
E
M
I
E
T
G
V
F
G
D
L
N
V
W
R
P
--------------------------------------------------------------
12
PsiBlast_PDB
77.59
47%
-98
- C1 -
3C4W
1
RK_BOVIN
A:
[31-533]
----------------------------
R
D
R
K
Y
L
A
R
L
K
L
P
P
L
S
K
C
E
A
L
R
E
S
L
D
L
G
F
E
G
M
--
C
L
E
Q
P
I
G
K
R
L
F
Q
Q
F
L
-----
R
T
H
E
Q
H
G
P
A
L
Q
L
W
K
D
I
E
D
Y
D
-
T
--
A
D
D
A
L
R
P
Q
K
A
Q
A
L
R
A
A
Y
L
E
P
Q
A
Q
L
F
C
S
F
L
D
A
E
T
V
A
R
A
R
A
G
-----
A
G
D
-
G
L
F
Q
P
L
L
R
A
V
L
A
H
L
G
Q
A
P
F
Q
E
F
L
D
S
L
Y
F
L
R
F
L
Q
W
K
W
L
E
A
Q
-
P
M
G
E
D
W
F
L
D
F
R
V
L
G
R
G
G
F
G
E
V
F
A
C
Q
M
---
K
A
-----
T
G
----
K
L
Y
A
C
K
K
L
N
K
K
R
L
-
K
K
R
-
K
-
G
--
Y
Q
G
A
M
V
E
K
K
I
L
-
A
K
-
V
-
H
S
---
R
-
F
I
V
S
L
A
Y
A
F
E
T
K
T
D
L
C
L
V
M
T
I
M
N
G
G
D
I
R
Y
H
I
Y
N
V
D
ED
N
P
G
F
Q
E
P
R
A
I
F
Y
T
A
Q
I
V
S
G
L
E
H
L
H
Q
R
-
N
I
I
Y
R
D
L
K
P
E
N
V
L
L
D
D
D
G
----
N
V
R
I
S
D
L
G
L
A
V
E
-
L
-
K
A
G
-
Q
T
K
T
K
G
Y
A
----
G
T
P
G
F
M
A
P
E
L
L
L
-
G
E
E
Y
D
F
S
V
D
Y
F
A
L
G
V
T
L
Y
E
M
I
A
A
R
G
P
F
R
A
R
G
E
K
V
E
N
K
E
L
K
Q
R
V
L
E
Q
A
V
T
Y
P
D
K
F
S
P
A
S
K
D
F
C
E
A
L
L
Q
K
D
P
E
K
R
L
G
F
R
-
D
G
S
C
D
G
-
L
R
T
H
P
L
F
R
D
I
S
W
R
Q
L
E
A
G
M
L
T
P
P
F
V
P
D
---------
Q
D
V
G
A
F
S
---
T
V
K
G
V
A
F
E
K
A
D
T
E
F
F
Q
E
F
A
S
G
T
C
P
I
P
W
Q
E
E
M
I
E
T
G
V
F
G
D
L
N
V
W
R
P
--------------------------------------------------------------
11
PsiBlast_PDB
76.46
47%
-95
- C1 -
3C51
1
RK_BOVIN
A:
[31-533]
----------------------------
R
D
R
K
Y
L
A
R
L
K
L
P
P
L
S
K
C
E
A
L
R
E
S
L
D
L
G
F
E
G
M
--
C
L
E
Q
P
I
G
K
R
L
F
Q
Q
F
L
-----
R
T
H
E
Q
H
G
P
A
L
Q
L
W
K
D
I
E
D
Y
D
-
T
--
A
D
D
A
L
R
P
Q
K
A
Q
A
L
R
A
A
Y
L
E
P
Q
A
Q
L
F
C
S
F
L
D
A
E
T
V
A
R
A
R
A
G
---------
G
L
F
Q
P
L
L
R
A
V
L
A
H
L
G
Q
A
P
F
Q
E
F
L
D
S
L
Y
F
L
R
F
L
Q
W
K
W
L
E
A
Q
-
P
M
G
E
D
W
F
L
D
F
R
V
L
G
R
G
G
F
G
E
V
F
A
C
Q
M
---
K
A
-----
T
G
----
K
L
Y
A
C
K
K
L
N
K
K
R
L
-
K
K
R
-
K
-
G
--
Y
Q
G
A
M
V
E
K
K
I
L
-
A
K
-
V
-
H
S
---
R
-
F
I
V
S
L
A
Y
A
F
E
T
K
T
D
L
C
L
V
M
T
I
M
N
G
G
D
I
R
Y
H
I
Y
N
V
D
ED
N
P
G
F
Q
E
P
R
A
I
F
Y
T
A
Q
I
V
S
G
L
E
H
L
H
Q
R
-
N
I
I
Y
R
D
L
K
P
E
N
V
L
L
D
D
D
G
----
N
V
R
I
S
D
L
G
L
A
V
E
-
L
-
K
A
G
-
Q
T
K
T
K
G
Y
A
----
G
T
P
G
F
M
A
P
E
L
L
L
-
G
E
E
Y
D
F
S
V
D
Y
F
A
L
G
V
T
L
Y
E
M
I
A
A
R
G
P
F
R
A
R
G
E
K
V
E
N
K
E
L
K
Q
R
V
L
E
Q
A
V
T
Y
P
D
K
F
S
P
A
S
K
D
F
C
E
A
L
L
Q
K
D
P
E
K
R
L
G
F
R
-
D
G
S
C
D
G
-
L
R
T
H
P
L
F
R
D
I
S
W
R
Q
L
E
A
G
M
L
T
P
P
F
V
P
D
S
R
-------------
S
---
T
V
K
G
V
A
F
E
K
A
D
T
E
F
F
Q
E
F
A
S
G
T
C
P
I
P
W
Q
E
E
M
I
E
T
G
V
F
G
D
L
N
V
W
R
P
--------------------------------------------------------------
37
PsiBlast_CBE
67.14
37%
-90
- C1 -
3PVU
1
ARBK1_BOVIN
A:
[30-531]
-------------------------------
K
-
K
I
L
L
P
E
P
S
I
R
S
V
M
Q
-
K
Y
L
E
D
R
G
E
V
T
F
E
K
I
F
S
Q
K
L
G
Y
L
L
F
R
D
F
C
L
KHLE
E
A
K
P
----
L
V
E
F
Y
E
E
I
K
K
Y
E
-
K
LE
T
E
E
E
R
L
V
-
C
S
R
E
I
F
D
T
Y
I
M
K
E
L
L
A
C
S
H
P
F
S
K
S
A
I
E
H
V
Q
G
H
L
V
K
K
-
Q
V
P
P
D
L
F
Q
P
Y
I
E
E
I
C
Q
N
L
R
G
D
V
F
Q
K
F
I
E
S
D
K
F
T
R
F
C
Q
W
K
N
V
E
L
N
I
H
L
T
M
N
D
F
S
V
H
R
I
I
G
R
G
G
F
G
E
V
Y
G
C
R
K
---
A
D
-----
T
G
----
K
M
Y
A
M
K
C
L
D
K
K
R
I
-
K
M
K
-
Q
-
G
--
E
T
L
A
L
N
E
R
I
M
L
-
S
L
-
V
-
S
T
GDC
P
-
F
I
V
C
M
S
Y
A
F
H
T
P
D
K
L
S
F
I
L
D
L
M
N
G
G
D
L
H
Y
H
L
S
Q
H
G
--
V
--
F
S
E
A
D
M
R
F
Y
A
A
E
I
I
L
G
L
E
H
M
H
N
R
-
F
V
V
Y
R
D
L
K
P
A
N
I
L
L
D
E
H
G
----
H
V
R
I
S
D
L
G
L
A
C
D
-
F
-
S
K
K
-
K
--
P
H
A
S
V
----
G
T
H
G
Y
M
A
P
E
V
L
Q
K
G
V
A
Y
D
S
S
A
D
W
F
S
L
G
C
M
L
F
K
L
L
R
G
H
S
P
F
R
Q
H
K
T
K
D
K
H
-
E
I
D
R
M
T
L
T
M
A
V
E
L
P
D
S
F
S
P
E
L
R
S
L
L
E
G
L
L
Q
R
D
V
N
R
R
L
G
C
L
-
G
R
G
A
Q
E
-
V
K
E
S
P
F
F
R
S
L
D
W
Q
M
V
F
L
Q
K
Y
P
P
P
L
I
P
P
R
G
-------------------------
D
S
D
Q
E
L
Y
R
N
F
P
L
-
T
I
S
E
R
W
Q
Q
E
V
A
E
T
-
V
F
D
T
I
N
A
E
T
D
R
L
E
A
R
K
K
T
K
-
N
K
Q
L
G
H
E
E
D
Y
A
L
G
K
D
C
I
M
H
G
Y
M
S
K
M
G
W
Q
R
R
Y
F
Y
L
F
P
N
R
L
E
W
R
G
E
G
E
A
P
Q
S
L
L
36
PsiBlast_CBE
66.96
37%
-86
- C1 -
3PVW
1
ARBK1_BOVIN
A:
[29-531]
------------------------------
S
K
-
K
I
L
L
P
E
P
S
I
R
S
V
M
Q
-
K
Y
L
E
D
R
G
E
V
T
F
E
K
I
F
S
Q
K
L
G
Y
L
L
F
R
D
F
C
L
KHLE
E
A
K
P
----
L
V
E
F
Y
E
E
I
K
K
Y
E
-
K
LE
T
E
E
E
R
L
V
-
C
S
R
E
I
F
D
T
Y
I
M
K
E
L
L
A
C
S
H
P
F
S
K
S
A
I
E
H
V
Q
G
H
L
V
K
K
-
Q
V
P
P
D
L
F
Q
P
Y
I
E
E
I
C
Q
N
L
R
G
D
V
F
Q
K
F
I
E
S
D
K
F
T
R
F
C
Q
W
K
N
V
E
L
N
I
H
L
T
M
N
D
F
S
V
H
R
I
I
G
R
G
G
F
G
E
V
Y
G
C
R
K
---
A
D
-----
T
G
----
K
M
Y
A
M
K
C
L
D
K
K
R
I
-
K
M
K
-
Q
-
G
--
E
T
L
A
L
N
E
R
I
M
L
-
S
L
-
V
-
S
T
GDC
P
-
F
I
V
C
M
S
Y
A
F
H
T
P
D
K
L
S
F
I
L
D
L
M
N
G
G
D
L
H
Y
H
L
S
Q
H
G
--
V
--
F
S
E
A
D
M
R
F
Y
A
A
E
I
I
L
G
L
E
H
M
H
N
R
-
F
V
V
Y
R
D
L
K
P
A
N
I
L
L
D
E
H
G
----
H
V
R
I
S
D
L
G
L
A
C
D
-
F
-
S
K
K
-
K
--
P
H
A
S
V
----
G
T
H
G
Y
M
A
P
E
V
L
Q
K
G
V
A
Y
D
S
S
A
D
W
F
S
L
G
C
M
L
F
K
L
L
R
G
H
S
P
F
R
Q
H
K
T
K
D
K
H
-
E
I
D
R
M
T
L
T
M
A
V
E
L
P
D
S
F
S
P
E
L
R
S
L
L
E
G
L
L
Q
R
D
V
N
R
R
L
G
C
L
-
G
R
G
A
Q
E
-
V
K
E
S
P
F
F
R
S
L
D
W
Q
M
V
F
L
Q
K
Y
P
P
P
L
I
P
P
R
G
----------------------
K
L
L
D
S
D
Q
E
L
Y
R
N
F
P
L
-
T
I
S
E
R
W
Q
Q
E
V
A
E
T
-
V
F
D
T
I
N
A
E
T
D
R
L
E
A
R
K
K
T
K
-
N
K
Q
L
G
H
E
E
D
Y
A
L
G
K
D
C
I
M
H
G
Y
M
S
K
M
G
W
Q
R
R
Y
F
Y
L
F
P
N
R
L
E
W
R
G
E
G
E
A
P
Q
S
L
L
16
PsiBlast_PDB
66.26
37%
-85
- C1 -
4PNK
1
ARBK1_HUMAN
A:
[30-531]
-------------------------------
K
-
K
I
L
L
P
E
P
S
I
R
S
V
M
Q
-
K
Y
L
E
D
R
G
E
V
T
F
E
K
I
F
S
Q
K
L
G
Y
L
L
F
R
D
F
C
L
N
HLE
E
A
R
P
----
L
V
E
F
Y
E
E
I
K
K
Y
E
K
L
--
E
T
E
E
E
R
V
A
R
S
R
E
I
F
D
S
Y
I
M
K
E
L
L
A
C
S
H
P
F
S
K
S
A
T
E
H
V
Q
G
H
L
G
K
K
-
Q
V
P
P
D
L
F
Q
P
Y
I
E
E
I
C
Q
N
L
R
G
D
V
F
Q
K
F
I
E
S
D
K
F
T
R
F
C
Q
W
K
N
V
E
L
N
I
H
L
T
M
N
D
F
S
V
H
R
I
I
G
R
G
G
F
G
E
V
Y
G
C
R
K
---
A
D
-----
T
G
----
K
M
Y
A
M
K
C
L
D
K
K
R
I
-
K
M
K
-
Q
-
G
--
E
T
L
A
L
N
E
R
I
M
L
-
S
L
-
V
-
S
T
GDC
P
-
F
I
V
C
M
S
Y
A
F
H
T
P
D
K
L
S
F
I
L
D
L
M
N
G
G
D
L
H
Y
H
L
S
Q
H
G
--
V
--
F
S
E
A
D
M
R
F
Y
A
A
E
I
I
L
G
L
E
H
M
H
N
R
-
F
V
V
Y
R
D
L
K
P
A
N
I
L
L
D
E
H
G
----
H
V
R
I
S
D
L
G
L
A
C
D
-
F
-
S
K
K
-
K
--
P
H
A
S
V
----
G
T
H
G
Y
M
A
P
E
V
L
Q
K
G
V
A
Y
D
S
S
A
D
W
F
S
L
G
C
M
L
F
K
L
L
R
G
H
S
P
F
R
Q
H
K
T
K
D
K
-
H
E
I
D
R
M
T
L
T
M
A
V
E
L
P
D
S
F
S
P
E
L
R
S
L
L
E
G
L
L
Q
R
D
V
N
R
R
L
G
C
L
-
G
R
G
A
Q
E
-
V
K
E
S
P
F
F
R
S
L
D
W
Q
M
V
F
L
Q
K
Y
P
P
P
L
I
P
P
R
-
E
V
N
A
--------------
T
K
G
I
K
L
L
D
S
D
Q
E
L
Y
R
N
F
P
L
-
T
I
S
E
R
W
Q
Q
E
V
A
E
T
-
V
F
D
T
I
N
A
E
T
D
R
L
E
A
R
K
K
A
K
-
N
K
Q
L
G
H
E
E
D
Y
A
L
G
K
D
C
I
M
H
G
Y
M
S
K
M
G
N
P
F
L
T
Q
W
Q
R
R
Y
F
Y
L
F
P
N
R
L
E
W
R
G
E
G
E
17
PsiBlast_PDB
64.75
37%
-85
- C1 -
3KRW
1
ARBK1_HUMAN
A:
[29-530]
-------------------------------
K
-
K
I
L
L
P
E
P
S
I
R
S
V
M
Q
-
K
Y
L
E
D
R
G
E
V
T
F
E
K
I
F
S
Q
K
L
G
Y
L
L
F
R
D
F
C
L
NHLE
E
A
R
P
----
L
V
E
F
Y
E
E
I
K
K
Y
E
K
L
--
E
T
E
E
E
R
V
A
R
S
R
E
I
F
D
S
Y
I
M
K
E
L
L
A
--
H
P
F
S
K
S
A
T
E
H
V
Q
G
H
L
G
K
K
-
Q
V
P
P
D
L
F
Q
P
Y
I
E
E
I
C
Q
N
L
R
G
D
V
F
Q
K
F
I
E
S
D
K
F
T
R
F
C
Q
W
K
N
V
E
L
N
I
H
L
T
M
N
D
F
S
V
H
R
I
I
G
R
G
G
F
G
E
V
Y
G
C
R
K
---
A
D
-----
T
G
----
K
M
Y
A
M
K
C
L
D
K
K
R
I
-
K
M
K
-
Q
-
G
--
E
T
L
A
L
N
E
R
I
M
L
-
S
L
-
V
-
S
T
GDC
P
-
F
I
V
C
M
S
Y
A
F
H
T
P
D
K
L
S
F
I
L
D
L
M
N
G
G
D
L
H
Y
H
L
S
Q
H
G
--
V
--
F
S
E
A
D
M
R
F
Y
A
A
E
I
I
L
G
L
E
H
M
H
N
R
-
F
V
V
Y
R
D
L
K
P
A
N
I
L
L
D
E
H
G
----
H
V
R
I
S
D
L
G
L
A
C
D
-
F
-
S
K
K
-
K
--
P
H
A
S
V
----
G
T
H
G
Y
M
A
P
E
V
L
Q
K
G
V
A
Y
D
S
S
A
D
W
F
S
L
G
C
M
L
F
K
L
L
R
G
H
S
P
F
R
Q
H
K
T
K
D
K
-
H
E
I
D
R
M
T
L
T
M
A
V
E
L
P
D
S
F
S
P
E
L
R
S
L
L
E
G
L
L
Q
R
D
V
N
R
R
L
G
C
L
-
G
R
G
A
Q
E
-
V
K
E
S
P
F
F
R
S
L
D
W
Q
M
V
F
L
Q
K
Y
P
P
P
L
I
P
P
R
---------------EE-
D
T
K
G
I
K
L
L
D
S
D
Q
E
L
Y
R
N
F
P
L
-
T
I
S
E
R
W
Q
Q
E
V
A
E
T
-
V
F
D
T
I
N
A
E
T
D
R
L
E
A
R
K
K
A
K
-
N
K
Q
L
G
H
E
E
D
Y
A
L
G
K
D
C
I
M
H
G
Y
M
S
K
M
W
Q
R
R
Y
F
Y
L
F
P
N
R
L
E
W
R
G
E
G
E
A
P
Q
S
L
L
T
18
PsiBlast_PDB
64.08
37%
-83
- C1 -
3KRX
1
ARBK1_HUMAN
A:
[29-530]
-------------------------------
K
-
K
I
L
L
P
E
P
S
I
R
S
V
M
Q
-
K
Y
L
E
D
R
G
E
V
T
F
E
K
I
F
S
Q
K
L
G
Y
L
L
F
R
D
F
C
L
NHLE
E
A
R
P
----
L
V
E
F
Y
E
E
I
K
K
Y
E
K
L
--
E
T
E
E
E
R
V
A
R
S
R
E
I
F
D
S
Y
I
M
K
E
L
L
A
--
H
P
F
S
K
S
A
T
E
H
V
Q
G
H
L
G
K
K
-
Q
V
P
P
D
L
F
Q
P
Y
I
E
E
I
C
Q
N
L
R
G
D
V
F
Q
K
F
I
E
S
D
K
F
T
R
F
C
Q
W
K
N
V
E
L
N
I
H
L
T
M
N
D
F
S
V
H
R
I
I
G
R
G
G
F
G
E
V
Y
G
C
R
K
---
A
D
-----
T
G
----
K
M
Y
A
M
K
C
L
D
K
K
R
I
-
K
M
K
-
Q
-
G
--
E
T
L
A
L
N
E
R
I
M
L
-
S
L
-
V
-
S
T
GDC
P
-
F
I
V
C
M
S
Y
A
F
H
T
P
D
K
L
S
F
I
L
D
L
M
N
G
G
D
L
H
Y
H
L
S
Q
H
G
--
V
--
F
S
E
A
D
M
R
F
Y
A
A
E
I
I
L
G
L
E
H
M
H
N
R
-
F
V
V
Y
R
D
L
K
P
A
N
I
L
L
D
E
H
G
----
H
V
R
I
S
D
L
G
L
A
C
D
-
F
-
S
K
K
-
K
--
P
H
A
S
V
----
G
T
H
G
Y
M
A
P
E
V
L
Q
K
G
V
A
Y
D
S
S
A
D
W
F
S
L
G
C
M
L
F
K
L
L
R
G
H
S
P
F
R
Q
H
K
T
K
D
K
-
H
E
I
D
R
M
T
L
T
M
A
V
E
L
P
D
S
F
S
P
E
L
R
S
L
L
E
G
L
L
Q
R
D
V
N
R
R
L
G
C
L
-
G
R
G
A
Q
E
-
V
K
E
S
P
F
F
R
S
L
D
W
Q
M
V
F
L
Q
K
Y
P
P
P
L
I
P
P
R
---------------EE-
D
T
K
G
I
K
L
L
D
S
D
Q
E
L
Y
R
N
F
P
L
-
T
I
S
E
R
W
Q
Q
E
V
A
E
T
-
V
F
D
T
I
N
A
E
T
D
R
L
E
A
R
K
K
A
K
-
N
K
Q
L
G
H
E
E
D
Y
A
L
G
K
D
C
I
M
H
G
Y
M
S
K
M
W
Q
R
R
Y
F
Y
L
F
P
N
R
L
E
W
R
G
E
G
E
A
P
Q
S
L
L
T
22
PsiBlast_CBE
56.20
72%
25
- C1 -
3NYO
2
GRK6_HUMAN
B:
[4-557]
-
E
L
E
N
I
V
A
N
T
V
L
L
K
A
R
E
G
G
G
G
N
R
K
G
---
K
S
K
K
W
R
Q
M
L
Q
F
P
H
I
S
Q
C
E
E
L
R
L
S
L
E
R
D
Y
H
S
L
--
C
E
R
Q
P
I
G
R
L
L
F
R
E
F
C
-----
A
T
R
P
E
L
S
R
C
V
A
F
L
D
G
V
A
E
Y
E
-
V
--
T
P
D
D
K
R
K
A
C
G
R
Q
L
T
Q
N
F
L
S
H
T
G
P
D
L
I
P
E
V
P
R
Q
L
V
T
N
C
T
Q
R
L
E
Q
G
-
P
C
K
-
D
L
F
Q
E
L
T
R
L
T
H
E
Y
L
S
V
A
P
F
A
D
Y
L
D
S
I
Y
F
N
R
F
L
Q
W
K
W
L
E
R
Q
-
P
V
T
K
N
T
F
R
Q
Y
R
V
L
G
K
G
G
F
G
E
V
C
A
C
Q
V
---
R
A
-----
T
G
----
K
M
Y
A
C
K
K
L
E
K
K
R
I
-
K
K
R
-
K
-
G
--
E
A
M
A
L
N
E
K
Q
I
L
-
E
K
-
V
-
N
S
---
R
-
F
V
V
S
L
A
Y
A
Y
E
T
K
D
A
L
C
L
V
L
T
L
M
N
G
G
D
L
K
F
H
I
Y
H
M
G
--
Q
A
G
F
P
E
A
R
A
V
F
Y
A
A
E
I
C
C
G
L
E
D
L
H
R
E
-
R
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
D
H
G
----
H
I
R
I
S
D
L
G
L
A
V
H
-
V
-
P
E
G
-
Q
T
-
I
K
G
R
V
----
G
T
V
G
Y
M
A
P
E
V
V
K
-
N
E
R
Y
T
F
S
P
D
W
W
A
L
G
C
L
L
Y
E
M
I
A
G
Q
S
P
F
Q
---
K
K
I
K
R
E
E
V
E
R
L
V
K
E
V
P
E
E
Y
S
E
R
F
S
P
Q
A
R
S
L
C
S
Q
L
L
C
K
D
P
A
E
R
L
G
C
R
-
G
G
S
A
R
E
-
V
K
E
H
P
L
F
K
K
L
N
F
K
R
L
G
A
G
M
L
E
P
P
F
K
P
D
P
Q
A
I
Y
C
K
D
V
L
D
I
E
Q
F
S
---
T
V
K
G
V
E
L
E
P
T
D
Q
D
F
Y
Q
K
F
A
T
G
S
V
P
I
P
W
Q
N
E
M
V
E
T
E
C
F
Q
E
L
N
V
F
G
L
D
G
S
V
P
P
D
L
D
W
K
G
Q
P
P
A
P
P
K
K
G
L
L
Q
R
L
F
S
----------------------------------
5
PsiBlast_PDB
55.51
72%
29
- C1 -
3NYN
2
GRK6_HUMAN
A:
[4-557]
-
E
L
E
N
I
V
A
N
T
V
L
L
K
A
R
E
G
G
G
G
N
R
K
G
---
K
S
K
K
W
R
Q
M
L
Q
F
P
H
I
S
Q
C
E
E
L
R
L
S
L
E
R
D
Y
H
S
L
--
C
E
R
Q
P
I
G
R
L
L
F
R
E
F
C
-----
A
T
R
P
E
L
S
R
C
V
A
F
L
D
G
V
A
E
Y
E
-
V
--
T
P
D
D
K
R
K
A
C
G
R
Q
L
T
Q
N
F
L
S
H
T
G
P
D
L
I
P
E
V
P
R
Q
L
V
T
N
C
T
Q
R
L
E
Q
G
-
P
C
K
-
D
L
F
Q
E
L
T
R
L
T
H
E
Y
L
S
V
A
P
F
A
D
Y
L
D
S
I
Y
F
N
R
F
L
Q
W
K
W
L
E
R
Q
-
P
V
T
K
N
T
F
R
Q
Y
R
V
L
G
K
G
G
F
G
E
V
C
A
C
Q
V
---
R
A
-----
T
G
----
K
M
Y
A
C
K
K
L
E
K
K
R
I
-
K
K
R
-
K
-
G
--
E
A
M
A
L
N
E
K
Q
I
L
-
E
K
-
V
-
N
S
---
R
-
F
V
V
S
L
A
Y
A
Y
E
T
K
D
A
L
C
L
V
L
T
L
M
N
G
G
D
L
K
F
H
I
Y
H
M
G
--
Q
A
G
F
P
E
A
R
A
V
F
Y
A
A
E
I
C
C
G
L
E
D
L
H
R
E
-
R
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
D
H
G
----
H
I
R
I
S
D
L
G
L
A
V
H
-
V
-
P
E
G
-
Q
T
-
I
K
G
R
V
----
G
T
V
G
Y
M
A
P
E
V
V
K
-
N
E
R
Y
T
F
S
P
D
W
W
A
L
G
C
L
L
Y
E
M
I
A
G
Q
S
P
F
Q
---
K
K
I
K
R
E
E
V
E
R
L
V
K
E
V
P
E
E
Y
S
E
R
F
S
P
Q
A
R
S
L
C
S
Q
L
L
C
K
D
P
A
E
R
L
G
C
R
-
G
G
S
A
R
E
-
V
K
E
H
P
L
F
K
K
L
N
F
K
R
L
G
A
G
M
L
E
P
P
F
K
P
D
P
Q
A
I
Y
C
K
D
V
L
D
I
E
Q
F
S
---
T
V
K
G
V
E
L
E
P
T
D
Q
D
F
Y
Q
K
F
A
T
G
S
V
P
I
P
W
Q
N
E
M
V
E
T
E
C
F
Q
E
L
N
V
F
G
L
D
G
S
V
P
P
D
L
D
W
K
G
Q
P
P
A
P
P
K
K
G
L
L
Q
R
L
F
S
----------------------------------
6
PsiBlast_PDB
55.36
72%
30
- C1 -
3NYO
2
GRK6_HUMAN
A:
[4-557]
-
E
L
E
N
I
V
A
N
T
V
L
L
K
A
R
E
G
G
G
G
N
R
K
G
---
K
S
K
K
W
R
Q
M
L
Q
F
P
H
I
S
Q
C
E
E
L
R
L
S
L
E
R
D
Y
H
S
L
--
C
E
R
Q
P
I
G
R
L
L
F
R
E
F
C
-----
A
T
R
P
E
L
S
R
C
V
A
F
L
D
G
V
A
E
Y
E
-
V
--
T
P
D
D
K
R
K
A
C
G
R
Q
L
T
Q
N
F
L
S
H
T
G
P
D
L
I
P
E
V
P
R
Q
L
V
T
N
C
T
Q
R
L
E
Q
G
-
P
C
K
-
D
L
F
Q
E
L
T
R
L
T
H
E
Y
L
S
V
A
P
F
A
D
Y
L
D
S
I
Y
F
N
R
F
L
Q
W
K
W
L
E
R
Q
-
P
V
T
K
N
T
F
R
Q
Y
R
V
L
G
K
G
G
F
G
E
V
C
A
C
Q
V
---
R
A
-----
T
G
----
K
M
Y
A
C
K
K
L
E
K
K
R
I
-
K
K
R
-
K
-
G
--
E
A
M
A
L
N
E
K
Q
I
L
-
E
K
-
V
-
N
S
---
R
-
F
V
V
S
L
A
Y
A
Y
E
T
K
D
A
L
C
L
V
L
T
L
M
N
G
G
D
L
K
F
H
I
Y
H
M
G
--
Q
A
G
F
P
E
A
R
A
V
F
Y
A
A
E
I
C
C
G
L
E
D
L
H
R
E
-
R
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
D
H
G
----
H
I
R
I
S
D
L
G
L
A
V
H
-
V
-
P
E
G
-
Q
T
-
I
K
G
R
V
----
G
T
V
G
Y
M
A
P
E
V
V
K
-
N
E
R
Y
T
F
S
P
D
W
W
A
L
G
C
L
L
Y
E
M
I
A
G
Q
S
P
F
Q
---
K
K
I
K
R
E
E
V
E
R
L
V
K
E
V
P
E
E
Y
S
E
R
F
S
P
Q
A
R
S
L
C
S
Q
L
L
C
K
D
P
A
E
R
L
G
C
R
-
G
G
S
A
R
E
-
V
K
E
H
P
L
F
K
K
L
N
F
K
R
L
G
A
G
M
L
E
P
P
F
K
P
D
P
Q
A
I
Y
C
K
D
V
L
D
I
E
Q
F
S
---
T
V
K
G
V
E
L
E
P
T
D
Q
D
F
Y
Q
K
F
A
T
G
S
V
P
I
P
W
Q
N
E
M
V
E
T
E
C
F
Q
E
L
N
V
F
G
L
D
G
S
V
P
P
D
L
D
W
K
G
Q
P
P
A
P
P
K
K
G
L
L
Q
R
L
F
S
----------------------------------
23
PsiBlast_CBE
55.14
72%
31
- C1 -
3NYN
2
GRK6_HUMAN
B:
[4-557]
-
E
L
E
N
I
V
A
N
T
V
L
L
K
A
R
E
G
G
G
G
N
R
K
G
---
K
S
K
K
W
R
Q
M
L
Q
F
P
H
I
S
Q
C
E
E
L
R
L
S
L
E
R
D
Y
H
S
L
--
C
E
R
Q
P
I
G
R
L
L
F
R
E
F
C
-----
A
T
R
P
E
L
S
R
C
V
A
F
L
D
G
V
A
E
Y
E
-
V
--
T
P
D
D
K
R
K
A
C
G
R
Q
L
T
Q
N
F
L
S
H
T
G
P
D
L
I
P
E
V
P
R
Q
L
V
T
N
C
T
Q
R
L
E
Q
G
-
P
C
K
-
D
L
F
Q
E
L
T
R
L
T
H
E
Y
L
S
V
A
P
F
A
D
Y
L
D
S
I
Y
F
N
R
F
L
Q
W
K
W
L
E
R
Q
-
P
V
T
K
N
T
F
R
Q
Y
R
V
L
G
K
G
G
F
G
E
V
C
A
C
Q
V
---
R
A
-----
T
G
----
K
M
Y
A
C
K
K
L
E
K
K
R
I
-
K
K
R
-
K
-
G
--
E
A
M
A
L
N
E
K
Q
I
L
-
E
K
-
V
-
N
S
---
R
-
F
V
V
S
L
A
Y
A
Y
E
T
K
D
A
L
C
L
V
L
T
L
M
N
G
G
D
L
K
F
H
I
Y
H
M
G
--
Q
A
G
F
P
E
A
R
A
V
F
Y
A
A
E
I
C
C
G
L
E
D
L
H
R
E
-
R
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
D
H
G
----
H
I
R
I
S
D
L
G
L
A
V
H
-
V
-
P
E
G
-
Q
T
-
I
K
G
R
V
----
G
T
V
G
Y
M
A
P
E
V
V
K
-
N
E
R
Y
T
F
S
P
D
W
W
A
L
G
C
L
L
Y
E
M
I
A
G
Q
S
P
F
Q
---
K
K
I
K
R
E
E
V
E
R
L
V
K
E
V
P
E
E
Y
S
E
R
F
S
P
Q
A
R
S
L
C
S
Q
L
L
C
K
D
P
A
E
R
L
G
C
R
-
G
G
S
A
R
E
-
V
K
E
H
P
L
F
K
K
L
N
F
K
R
L
G
A
G
M
L
E
P
P
F
K
P
D
P
Q
A
I
Y
C
K
D
V
L
D
I
E
Q
F
S
---
T
V
K
G
V
E
L
E
P
T
D
Q
D
F
Y
Q
K
F
A
T
G
S
V
P
I
P
W
Q
N
E
M
V
E
T
E
C
F
Q
E
L
N
V
F
G
L
D
G
S
V
P
P
D
L
D
W
K
G
Q
P
P
A
P
P
K
K
G
L
L
Q
R
L
F
S
----------------------------------
54
PsiBlast_CBE
53.75
40%
-98
- C1 -
3OW4
1
AKT1_HUMAN
B:
[6-288]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
T
M
N
E
F
E
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
K
E
---
K
A
-----
T
G
----
R
Y
Y
A
M
K
I
L
K
K
E
V
I
-
V
A
K
-
D
-
E
--
V
A
H
T
L
T
E
N
R
V
L
-
Q
N
-
S
-
R
H
---
P
-
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
----
E
R
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
K
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
K
D
G
----
H
I
K
I
T
D
F
G
L
C
K
E
G
I
-
K
D
G
-
A
T
-
M
K
T
F
C
----
G
T
P
E
Y
L
A
P
E
V
L
E
-
D
N
D
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
Y
N
Q
----
D
H
E
K
L
F
E
L
I
L
M
E
E
I
R
F
P
R
T
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
R
L
G
G
G
-
S
E
D
A
K
E
-
I
M
Q
H
R
F
F
A
G
I
V
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
P
Q
V
T
S
E
T
D
T
R
Y
F
D
E
E
F
T
A
---
Q
M
I
T
R
P
H
F
P
Q
F
D
Y
S
A
S
S
------------------------------------------------------------------------------------------
46
PsiBlast_CBE
53.56
40%
-95
- C1 -
3CQU
1
AKT1_HUMAN
A:
[7-289]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
T
M
N
E
F
E
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
K
E
---
K
A
-----
T
G
----
R
Y
Y
A
M
K
I
L
K
K
E
V
I
-
V
A
K
-
D
-
E
--
V
A
H
T
L
T
E
N
R
V
L
-
Q
N
-
S
-
R
H
---
P
-
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
----
E
R
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
K
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
K
D
G
----
H
I
K
I
T
D
F
G
L
C
K
E
G
I
-
K
D
G
-
A
T
-
M
K
T
F
C
----
G
T
P
E
Y
L
A
P
E
V
L
E
-
D
N
D
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
Y
N
Q
----
D
H
E
K
L
F
E
L
I
L
M
E
E
I
R
F
P
R
T
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
R
L
G
G
G
-
S
E
D
A
K
E
-
I
M
Q
H
R
F
F
A
G
I
V
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
P
Q
V
T
S
E
T
D
T
R
Y
F
D
E
E
F
T
A
---
Q
M
S
E
R
R
P
H
F
P
Q
F
D
Y
S
A
S
S
-----------------------------------------------------------------------------------------
43
PsiBlast_CBE
53.47
40%
-96
- C1 -
3MVH
1
AKT1_HUMAN
A:
[7-289]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
T
M
N
E
F
E
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
K
E
---
K
A
-----
T
G
----
R
Y
Y
A
M
K
I
L
K
K
E
V
I
-
V
A
K
-
D
-
E
--
V
A
H
T
L
T
E
N
R
V
L
-
Q
N
-
S
-
R
H
---
P
-
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
----
E
R
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
K
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
K
D
G
----
H
I
K
I
T
D
F
G
L
C
K
E
G
I
-
K
D
G
-
A
T
-
M
K
T
F
C
----
G
T
P
E
Y
L
A
P
E
V
L
E
-
D
N
D
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
Y
N
Q
----
D
H
E
K
L
F
E
L
I
L
M
E
E
I
R
F
P
R
T
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
R
L
G
G
G
-
S
E
D
A
K
E
-
I
M
Q
H
R
F
F
A
G
I
V
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
P
Q
V
T
S
E
T
D
T
R
Y
F
D
E
E
F
T
A
---
Q
R
P
H
F
P
Q
F
D
Y
S
A
-----------------------------------------------------------------------------------------------
50
PsiBlast_CBE
52.85
40%
-96
- C1 -
4EKK
1
AKT1_HUMAN
A:
[6-288]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
T
M
N
E
F
E
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
K
E
---
K
A
-----
T
G
----
R
Y
Y
A
M
K
I
L
K
K
E
V
I
-
V
A
K
-
D
-
E
--
V
A
H
T
L
T
E
N
R
V
L
-
Q
N
-
S
-
R
H
---
P
-
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
----
E
R
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
K
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
K
D
G
----
H
I
K
I
T
D
F
G
L
C
K
E
G
I
-
K
D
G
-
A
T
-
M
K
T
F
C
----
G
T
P
E
Y
L
A
P
E
V
L
E
-
D
N
D
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
Y
N
Q
----
D
H
E
K
L
F
E
L
I
L
M
E
E
I
R
F
P
R
T
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
R
L
G
G
G
-
S
E
D
A
K
E
-
I
M
Q
H
R
F
F
A
G
I
V
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
P
Q
V
T
S
E
T
D
T
R
Y
F
D
E
E
F
T
A
---
Q
M
I
S
E
R
R
P
H
F
P
Q
F
D
Y
S
A
S
-----------------------------------------------------------------------------------------
52
PsiBlast_CBE
52.74
40%
-95
- C1 -
3QKL
1
AKT1_HUMAN
A:
[6-288]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
T
M
N
E
F
E
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
K
E
---
K
A
-----
T
G
----
R
Y
Y
A
M
K
I
L
K
K
E
V
I
-
V
A
K
-
D
-
E
--
V
A
H
T
L
T
E
N
R
V
L
-
Q
N
-
S
-
R
H
---
P
-
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
----
E
R
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
K
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
K
D
G
----
H
I
K
I
T
D
F
G
L
C
K
E
G
I
-
K
D
G
-
A
T
-
M
K
T
F
C
----
G
T
P
E
Y
L
A
P
E
V
L
E
-
D
N
D
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
Y
N
Q
----
D
H
E
K
L
F
E
L
I
L
M
E
E
I
R
F
P
R
T
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
R
L
G
G
G
-
S
E
D
A
K
E
-
I
M
Q
H
R
F
F
A
G
I
V
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
P
Q
V
T
S
E
T
D
T
R
Y
F
D
E
E
F
T
A
---
Q
M
I
T
R
P
H
F
P
Q
F
D
Y
S
A
S
S
------------------------------------------------------------------------------------------
49
PsiBlast_CBE
52.19
40%
-95
- C1 -
4EKK
1
AKT1_HUMAN
B:
[6-288]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
T
M
N
E
F
E
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
K
E
---
K
A
-----
T
G
----
R
Y
Y
A
M
K
I
L
K
K
E
V
I
-
V
A
K
-
D
-
E
--
V
A
H
T
L
T
E
N
R
V
L
-
Q
N
-
S
-
R
H
---
P
-
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
----
E
R
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
K
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
K
D
G
----
H
I
K
I
T
D
F
G
L
C
K
E
G
I
-
K
D
G
-
A
T
-
M
K
T
F
C
----
G
T
P
E
Y
L
A
P
E
V
L
E
-
D
N
D
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
Y
N
Q
----
D
H
E
K
L
F
E
L
I
L
M
E
E
I
R
F
P
R
T
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
R
L
G
G
G
-
S
E
D
A
K
E
-
I
M
Q
H
R
F
F
A
G
I
V
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
P
Q
V
T
S
E
T
D
T
R
Y
F
D
E
E
F
T
A
---
Q
M
I
S
E
R
R
P
H
F
P
Q
F
D
Y
S
A
S
-----------------------------------------------------------------------------------------
57
PsiBlast_CBE
51.95
40%
-92
- C1 -
3OCB
1
AKT1_HUMAN
A:
[6-288]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
T
M
N
E
F
E
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
K
E
---
K
A
-----
T
G
----
R
Y
Y
A
M
K
I
L
K
K
E
V
I
-
V
A
K
-
D
-
E
--
V
A
H
T
L
T
E
N
R
V
L
-
Q
N
-
S
-
R
H
---
P
-
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
----
E
R
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
K
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
K
D
G
----
H
I
K
I
T
D
F
G
L
C
K
E
G
I
-
K
D
G
-
A
T
-
M
K
T
F
C
----
G
T
P
E
Y
L
A
P
E
V
L
E
-
D
N
D
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
Y
N
Q
----
D
H
E
K
L
F
E
L
I
L
M
E
E
I
R
F
P
R
T
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
R
L
G
G
G
-
S
E
D
A
K
E
-
I
M
Q
H
R
F
F
A
G
I
V
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
P
Q
V
T
S
E
T
D
T
R
Y
F
D
E
E
F
T
A
---
Q
M
R
P
H
F
P
Q
F
D
Y
S
A
S
S
--------------------------------------------------------------------------------------------
55
PsiBlast_CBE
51.80
40%
-98
- C1 -
3OW4
1
AKT1_HUMAN
A:
[6-288]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
T
M
N
E
F
E
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
K
E
---
K
A
-----
T
G
----
R
Y
Y
A
M
K
I
L
K
K
E
V
I
-
V
A
K
-
D
-
E
--
V
A
H
T
L
T
E
N
R
V
L
-
Q
N
-
S
-
R
H
---
P
-
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
----
E
R
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
K
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
K
D
G
----
H
I
K
I
T
D
F
G
L
C
K
E
G
I
-
K
D
G
-
A
T
-
M
K
T
F
C
----
G
T
P
E
Y
L
A
P
E
V
L
E
-
D
N
D
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
Y
N
Q
----
D
H
E
K
L
F
E
L
I
L
M
E
E
I
R
F
P
R
T
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
R
L
G
G
G
-
S
E
D
A
K
E
-
I
M
Q
H
R
F
F
A
G
I
V
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
P
Q
V
T
S
E
T
D
T
R
Y
F
D
E
E
F
T
A
---
Q
M
I
T
R
P
H
F
P
Q
F
D
Y
S
A
S
S
------------------------------------------------------------------------------------------
56
PsiBlast_CBE
50.79
40%
-96
- C1 -
3OCB
1
AKT1_HUMAN
B:
[6-288]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
T
M
N
E
F
E
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
K
E
---
K
A
-----
T
G
----
R
Y
Y
A
M
K
I
L
K
K
E
V
I
-
V
A
K
-
D
-
E
--
V
A
H
T
L
T
E
N
R
V
L
-
Q
N
-
S
-
R
H
---
P
-
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
----
E
R
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
K
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
K
D
G
----
H
I
K
I
T
D
F
G
L
C
K
E
G
I
-
K
D
G
-
A
T
-
M
K
T
F
C
----
G
T
P
E
Y
L
A
P
E
V
L
E
-
D
N
D
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
Y
N
Q
----
D
H
E
K
L
F
E
L
I
L
M
E
E
I
R
F
P
R
T
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
R
L
G
G
G
-
S
E
D
A
K
E
-
I
M
Q
H
R
F
F
A
G
I
V
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
P
Q
V
T
S
E
T
D
T
R
Y
F
D
E
E
F
T
A
---
Q
M
I
T
I
T
R
P
H
F
P
Q
F
D
Y
S
A
S
S
----------------------------------------------------------------------------------------
119
HHSearch
50.72
35%
-82
- C1 -
4DC2
1
KPCI_MOUSE
A:
[49-373]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
L
Q
D
F
D
L
L
R
V
I
G
R
G
S
Y
A
K
V
L
L
V
R
L
---
K
K
-----
T
D
----
R
I
Y
A
M
R
V
V
K
K
E
L
V
-
N
--------
I
D
W
V
Q
T
E
K
H
V
F
-
E
Q
-
A
S
N
H
---
P
-
F
L
V
G
L
H
S
C
F
Q
T
E
S
R
L
F
F
V
I
E
Y
V
N
G
G
D
L
M
F
H
M
Q
R
Q
R
----
K
L
P
E
E
H
A
R
F
Y
S
A
E
I
S
L
A
L
N
Y
L
H
E
R
-
G
I
I
Y
R
D
L
K
L
D
N
V
L
L
D
S
E
G
----
H
I
K
L
T
D
Y
G
M
C
K
E
G
L
-
R
P
G
-
D
T
-
T
S
T
F
C
----
G
T
P
N
Y
I
A
P
E
I
L
R
-
G
E
D
Y
G
F
S
V
D
W
W
A
L
G
V
L
M
F
E
M
M
A
G
R
S
P
F
D
I
V
G
S
-
N
T
E
D
Y
L
F
Q
V
I
L
E
K
Q
I
R
I
P
R
S
L
S
V
K
A
A
S
V
L
K
S
F
L
N
K
D
P
K
E
R
L
G
C
H
P
Q
T
G
F
A
D
-
I
Q
G
H
P
F
F
R
N
V
D
W
D
M
M
E
Q
K
Q
V
V
P
P
F
K
P
N
I
-----
S
G
E
F
G
L
D
N
F
D
SQF
T
N
E
P
V
Q
L
T
P
D
D
D
D
I
V
R
K
I
D
Q
S
E
F
E
G
F
E
Y
I
N
P
----------------------------------------------------------------------------
130
HHSearch
49.61
37%
-88
- C1 -
3WF7
2
KS6B1_HUMAN
A:
[14-304]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
-
K
I
R
P
E
C
F
E
L
L
R
V
L
G
K
G
G
Y
G
K
V
F
Q
V
R
K
VTG
A
N
-----
T
G
----
K
I
F
A
M
K
V
L
K
K
A
M
I
-
V
R
N
A
K
-
D
--
T
A
H
T
K
A
E
R
N
I
L
-
E
E
-
V
-
K
H
---
P
-
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
E
----
G
I
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
K
-
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
H
Q
G
----
H
V
K
L
T
D
F
G
L
C
K
E
-
S
I
H
D
-----
T
H
T
F
C
----
G
T
I
E
Y
M
A
P
E
I
L
M
-
R
S
G
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
P
P
F
T
G
E
N
R
----
K
K
T
I
D
K
I
L
K
C
K
L
N
L
P
P
Y
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
R
L
G
A
G
-
P
G
D
A
G
E
-
V
Q
A
H
P
F
F
R
H
I
N
W
E
E
L
L
A
R
K
V
E
P
P
F
K
P
L
L
Q
----------------------------------------------------------------------------------------------------------------------------
120
HHSearch
49.49
31%
-82
- C1 -
1RDQ
3
KAPCA_MOUSE
E:
[28-333]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
K
W
E
T
P
S
Q
N
-
T
A
Q
L
D
Q
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
---
K
E
-----
S
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
-
V
K
L
-
K
-
Q
--
I
E
H
T
L
N
E
K
R
I
L
-
Q
A
-
V
-
N
F
---
P
-
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
G
----
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
----
Y
I
Q
V
T
D
F
G
F
A
K
R
-
V
-
K
G
R
----
T
W
T
L
C
----
G
T
P
E
A
L
A
P
E
I
I
L
-
S
K
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
----
I
Q
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
L
-
K
N
G
V
N
D
-
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
-----
G
P
G
D
T
S
N
F
D
---
D
Y
E
E
E
E
I
R
V
S
I
N
E
K
C
G
K
E
F
T
E
F
-------------------------------------------------------------------------------------
98
PsiBlast_CBE
48.34
32%
-92
- C1 -
2UZU
1
KAPCA_BOVIN
E:
[27-302]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
---
M
E
-----
T
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
-
V
K
L
-
K
-
Q
--
I
E
H
T
L
N
E
K
R
I
L
-
Q
A
-
V
-
N
F
---
P
-
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
--
R
--
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
----
Y
I
Q
V
T
D
F
G
F
A
K
R
----------
V
K
G
R
T
WTLC
G
T
P
E
Y
L
A
P
E
I
I
L
-
S
K
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
----
Q
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
L
-
K
D
G
V
N
D
-
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
---
E
I
R
V
S
I
N
E
K
C
G
K
E
F
S
E
F
------------------------------------------------------------------------------------------
96
PsiBlast_CBE
48.34
32%
-90
- C1 -
2UZW
1
KAPCA_BOVIN
E:
[27-302]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
---
M
E
-----
T
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
-
V
K
L
-
K
-
Q
--
I
E
H
T
L
N
E
K
R
I
L
-
Q
A
-
V
-
N
F
---
P
-
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
--
R
--
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
----
Y
I
Q
V
T
D
F
G
F
A
K
R
----------
V
K
G
R
T
WTLC
G
T
P
E
Y
L
A
P
E
I
I
L
-
S
K
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
----
Q
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
L
-
K
D
G
V
N
D
-
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
---
E
I
R
V
S
I
N
E
K
C
G
K
E
F
S
E
F
------------------------------------------------------------------------------------------
80
PsiBlast_CBE
48.28
37%
-97
- C1 -
3G51
1
KS6A3_MOUSE
A:
[24-304]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
Q
F
E
L
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
V
K
----
K
I
-----
S
G
SDAR
Q
L
Y
A
M
K
V
L
K
K
A
T
L
-
K
V
R
-
D
-------------
I
L
-
V
E
-
V
-
N
H
---
P
-
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
----
E
V
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
S
L
-
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
G
----
H
I
K
L
T
D
F
G
L
S
K
E
S
I
------------------
T
V
E
Y
M
A
P
E
V
V
N
-
R
R
G
H
T
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
T
L
P
F
Q
G
K
----
D
R
K
E
T
M
T
M
I
L
K
A
K
L
G
M
P
Q
F
L
S
P
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
R
L
G
A
G
-
P
D
G
V
E
E
-
I
K
R
H
S
F
F
S
T
I
D
W
N
K
L
Y
R
R
E
I
H
P
P
F
K
P
-------------------------------------------------------------------------------------------------------------------------------
78
PsiBlast_CBE
48.09
37%
-97
- C1 -
5D9K
2
?
B:
[30-310]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
Q
F
E
L
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
V
K
----
K
I
-----
S
G
SDAR
Q
L
Y
A
M
K
V
L
K
K
A
T
L
-
K
V
R
-
D
-
R
--
V
R
T
K
M
-
E
R
D
I
L
-
V
E
-
V
-
N
H
---
P
-
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
----
E
V
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
S
L
-
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
G
----
H
I
K
L
T
D
F
G
L
S
K
E
--------------
C
----
G
T
V
E
Y
M
A
P
E
V
V
N
-
R
R
G
H
T
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
T
L
P
F
Q
G
K
----
D
R
K
E
T
M
T
M
I
L
K
A
K
L
G
M
P
Q
F
L
S
P
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
R
L
G
A
G
-
P
D
G
V
E
E
-
I
K
R
H
S
F
F
S
T
I
D
W
N
K
L
Y
R
R
E
I
H
P
P
F
K
P
T
F
Y
F
D
P
-------------------------------------------------------------------------------------------------------------------------
67
PsiBlast_CBE
48.06
36%
-92
- C1 -
4RA5
1
B:
[7-286]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
L
H
K
M
L
G
K
G
S
F
G
K
V
F
L
A
E
F
---
K
K
-----
T
N
----
Q
F
F
A
I
K
A
L
K
K
D
V
V
-
L
M
D
-
D
-
D
--
V
E
C
T
M
V
E
K
R
V
L
-
S
L
-
A
-
W
E
---
H
P
F
L
T
H
M
F
C
T
F
Q
T
K
E
N
L
F
F
V
M
E
Y
L
N
G
G
D
L
M
Y
H
I
Q
S
C
H
--
K
--
F
D
L
S
R
A
T
F
Y
A
A
E
I
I
L
G
L
Q
F
L
H
S
K
-
G
I
V
Y
R
D
L
K
L
D
N
I
L
L
D
K
D
G
----
H
I
K
I
A
D
F
G
M
C
K
E
-
N
-
M
L
G
-
D
A
-
K
T
N
E
F
C---
G
T
P
D
Y
I
A
P
E
I
L
L
-
G
Q
K
Y
N
H
S
V
D
W
W
S
F
G
V
L
L
Y
E
M
L
I
G
Q
S
P
F
H
G
Q
D
E
----
E
E
L
F
H
S
I
R
M
D
N
P
F
Y
P
R
W
L
E
K
E
A
K
D
L
L
V
K
L
F
V
R
E
P
E
K
R
L
G
V
R
-----
G
D
-
I
R
Q
H
P
L
F
R
E
I
N
W
E
E
L
E
R
K
E
I
D
P
P
F
R
P
K
V
K
S
P
F
D
P
R
L
S
R
A
L
I
N
S
---
M
D
Q
N
M
F
R
N
F
S
F
M
N
P
G
M
-------------------------------------------------------------------------------------------
81
PsiBlast_CBE
48.04
37%
-93
- C1 -
5D9L
2
?
A:
[30-310]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
Q
F
E
L
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
V
K
----
K
I
-----
S
G
SDAR
Q
L
Y
A
M
K
V
L
K
K
A
T
L
-
K
V
R
-
D
-
R
--
V
R
T
K
M
-
E
R
D
I
L
-
V
E
-
V
-
N
H
---
P
-
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
----
E
V
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
S
L
-
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
G
----
H
I
K
L
T
D
F
G
L
S
K
E
-------------------
G
T
V
E
Y
M
A
P
E
V
V
N
-
R
R
G
H
T
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
T
L
P
F
Q
G
K
----
D
R
K
E
T
M
T
M
I
L
K
A
K
L
G
M
P
Q
F
L
S
P
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
R
L
G
A
G
-
P
D
G
V
E
E
-
I
K
R
H
S
F
F
S
T
I
D
W
N
K
L
Y
R
R
E
I
H
P
P
F
K
P
A
T
G
R
P
E
D
T
F
Y
F
D
P
------------------------------------------------------------------------------------------------------------------
79
PsiBlast_CBE
47.94
37%
-102
- C1 -
5D9K
2
?
A:
[30-310]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
Q
F
E
L
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
V
K
----
K
I
-----
S
G
SDAR
Q
L
Y
A
M
K
V
L
K
K
A
T
L
-
K
V
R
-
D
-
R
--
V
R
T
K
M
-
E
R
D
I
L
-
V
E
-
V
-
N
H
---
P
-
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
----
E
V
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
S
L
-
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
G
----
H
I
K
L
T
D
F
G
L
S
K
---------------
C
----
G
T
V
E
Y
M
A
P
E
V
V
N
-
R
R
G
H
T
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
T
L
P
F
Q
G
K
----
D
R
K
E
T
M
T
M
I
L
K
A
K
L
G
M
P
Q
F
L
S
P
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
R
L
G
A
G
-
P
D
G
V
E
E
-
I
K
R
H
S
F
F
S
T
I
D
W
N
K
L
Y
R
R
E
I
H
P
P
F
K
P
A
T
F
Y
F
D
P
------------------------------------------------------------------------------------------------------------------------
61
PsiBlast_CBE
47.83
38%
-88
- C1 -
3TXO
1
A:
[23-303]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
N
F
E
F
I
R
V
L
G
K
G
S
F
G
K
V
M
L
A
R
V
---
K
E
-----
T
G
----
D
L
Y
A
V
K
V
L
K
K
D
V
I
-
L
Q
D
-
D
-
D
--
V
E
C
T
M
T
E
K
R
I
L
-
S
L
-
A
R
N
H
---
P
-
F
L
T
Q
L
F
C
C
F
Q
T
P
D
R
L
F
F
V
M
E
F
V
N
G
G
D
L
M
F
H
I
Q
K
----
S
R
R
F
D
E
A
R
A
R
F
Y
A
A
E
I
I
S
A
L
M
F
L
H
D
K
-
G
I
I
Y
R
D
L
K
L
D
N
V
L
L
D
H
E
G
----
H
C
K
L
A
D
F
G
M
C
K
E
G
I
-
C
---------------
G
T
P
D
Y
I
A
P
E
I
L
Q
-
E
M
L
Y
G
P
A
V
D
W
W
A
M
G
V
L
L
Y
E
M
L
C
G
H
A
P
F
E
A
E
N
E
----
D
D
L
F
E
A
I
L
N
D
E
V
V
Y
P
T
W
L
H
E
D
A
T
G
I
L
K
S
F
M
T
K
N
P
T
M
R
L
G
S
L
-
T
Q
G
G
E
H
A
I
L
R
H
P
F
F
K
E
I
D
W
A
Q
L
N
H
R
Q
I
E
P
P
F
R
P
R
I
K
S
R
E
D
V
S
N
F
D
P
D
F
I
K
---
E
E
P
V
L
T
P
I
D
E
G
H
L
P
M
I
N
Q
D
E
F
R
N
F
E
Y
V
S
P
------------------------------------------------------------------------------
126
HHSearch
47.44
39%
-101
- C1 -
2R5T
1
SGK1_HUMAN
A:
[34-318]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
A
K
P
S
D
F
H
F
L
K
V
I
G
K
G
S
F
G
K
V
L
L
A
R
H
---
K
A
-----
E
E
----
V
F
Y
A
V
K
V
L
Q
K
K
A
I
-
L
-----------------
V
L
L
K
N
-
V
-
K
H
---
P
-
F
L
V
G
L
H
F
S
F
Q
T
A
D
K
L
Y
F
V
L
D
Y
I
N
G
G
E
L
F
Y
H
L
Q
R
E
----
R
C
F
L
E
P
R
A
R
F
Y
A
A
E
I
A
S
A
L
G
Y
L
H
S
L
-
N
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
S
Q
G
----
H
I
V
L
T
D
F
G
L
C
K
E
-
N
I
E
H
N
-
S
T
-
T
S
T
F
C
----
G
T
P
E
Y
L
A
P
E
V
L
H
-
K
Q
P
Y
D
R
T
V
D
W
W
C
L
G
A
V
L
Y
E
M
L
Y
G
L
P
P
F
Y
S
R
N
----
T
A
E
M
Y
D
N
I
L
N
K
P
L
Q
L
K
P
N
I
T
N
S
A
R
H
L
L
E
G
L
L
Q
K
D
R
T
K
R
L
G
A
--
K
D
D
F
M
E
-
I
K
S
H
V
F
F
S
L
I
N
W
D
D
L
I
N
K
K
I
T
P
P
F
N
P
N
V
S
G
---------------------------------------------------------------------------------------------------------------------------
71
PsiBlast_CBE
47.40
38%
-99
- C1 -
2Z7S
1
KS6A1_HUMAN
A:
[30-308]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
L
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
V
R
K
---
V
T
RPD--
S
G
----
H
L
Y
A
M
K
V
L
K
-----------------------
I
L
-
A
D
-
V
-
N
H
---
P
-
F
V
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
----
E
V
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
G
L
D
H
L
H
S
L
-
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
G
----
H
I
K
L
T
D
F
G
L
S
K
E
-------------------
G
T
V
E
Y
M
A
P
E
V
V
N
-
R
Q
G
H
S
H
S
A
D
W
W
S
Y
G
V
L
M
F
E
M
L
T
G
S
L
P
F
Q
G
K
----
D
R
K
E
T
M
T
L
I
L
K
A
K
L
G
M
P
Q
F
L
S
T
E
A
Q
S
L
L
R
A
L
F
K
R
N
P
A
N
R
L
G
S
G
-
P
D
G
A
E
E
-
I
K
R
H
V
F
Y
S
T
I
D
W
N
K
L
Y
R
R
E
I
K
P
P
F
K
P
-------------------------------------------------------------------------------------------------------------------------------
58
PsiBlast_CBE
47.38
37%
-93
- C1 -
3A61
1
KS6B1_HUMAN
A:
[19-299]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
L
L
R
V
L
G
K
G
G
Y
G
K
V
F
--
Q
V
---
R
K
V
T
GAN
T
G
----
K
I
F
A
M
K
V
L
K
-------------------
A
E
R
N
I
L
-
E
E
-
V
-
K
H
---
P
-
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
E
G
--
I
--
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
K
-
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
H
Q
G
----
H
V
K
L
T
D
F
G
-----------------------
G
T
I
E
Y
M
A
P
E
I
L
M
-
R
S
G
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
P
P
F
T
G
E
----
N
R
K
K
T
I
D
K
I
L
K
C
K
L
N
L
P
P
Y
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
R
L
G
A
G
-
P
G
D
A
G
E
-
V
Q
A
H
P
F
F
R
H
I
N
W
E
E
L
L
A
R
K
V
E
P
P
F
K
P
-------------------------------------------------------------------------------------------------------------------------------
99
PsiBlast_CBE
47.12
32%
-91
- C1 -
2UZT
1
KAPCA_BOVIN
A:
[27-302]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
---
M
E
-----
T
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
-
V
K
L
-
K
-
Q
--
I
E
H
T
L
N
E
K
R
I
L
-
Q
A
-
V
-
N
F
---
P
-
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
--
R
--
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
----
Y
I
Q
V
T
D
F
G
F
A
K
R
----------
V
K
G
R
T
W
T
LC
G
T
P
E
Y
L
A
P
E
I
I
L
-
S
K
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
----
Q
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
L
-
K
D
G
V
N
D
-
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
---
E
I
R
V
S
I
N
E
K
C
G
K
E
F
S
E
F
------------------------------------------------------------------------------------------
69
PsiBlast_CBE
47.12
36%
-91
- C1 -
4Q9Z
1
B:
[7-286]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
L
H
K
M
L
G
K
G
S
F
G
K
V
F
L
A
E
F
---
K
K
-----
T
N
----
Q
F
F
A
I
K
A
L
K
K
D
V
V
-
L
M
D
-
D
-
D
--
V
E
C
T
M
V
E
K
R
V
L
-
S
L
-
A
-
W
E
---
H
P
F
L
T
H
M
F
C
T
F
Q
T
K
E
N
L
F
F
V
M
E
Y
L
N
G
G
D
L
M
Y
H
I
Q
S
C
H
--
K
--
F
D
L
S
R
A
T
F
Y
A
A
E
I
I
L
G
L
Q
F
L
H
S
K
-
G
I
V
Y
R
D
L
K
L
D
N
I
L
L
D
K
D
G
----
H
I
K
I
A
D
F
G
M
C
K
E
-
N
-
M
L
G
-
D
A
-
K
T
N
E
F
C
---
G
T
P
D
Y
I
A
P
E
I
L
L
-
G
Q
K
Y
N
H
S
V
D
W
W
S
F
G
V
L
L
Y
E
M
L
I
G
Q
S
P
F
H
G
Q
D
E
----
E
E
L
F
H
S
I
R
M
D
N
P
F
Y
P
R
W
L
E
K
E
A
K
D
L
L
V
K
L
F
V
R
E
P
E
K
R
L
G
V
R
-----
G
D
-
I
R
Q
H
P
L
F
R
E
I
N
W
E
E
L
E
R
K
E
I
D
P
P
F
R
P
K
V
K
S
P
F
D
C
S
N
F
D
K
N
M
F
R
---
N
F
S
F
M
N
P
G
M
E
R
L
-----------------------------------------------------------------------------------------------
62
PsiBlast_CBE
47.02
39%
-91
- C1 -
4L3L
1
KS6B1_HUMAN
A:
[20-300]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
L
L
R
V
L
G
K
G
G
Y
G
K
V
F
--
Q
V
---
R
K
VTGAN
T
G
----
K
I
F
A
M
K
V
L
K
K
A
M
I
V
R
N
A
-
K
-
D
--
T
A
H
T
K
A
E
R
N
I
L
-
E
E
-
V
-
K
H
---
P
-
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
E
G
--
I
--
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
K
-
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
H
Q
G
----
H
V
K
L
T
D
F
G
L
C
K
E
S
I
-
H
D
G
-
T
V
-
T
H
T
F
C
----
G
T
I
E
Y
M
A
P
E
I
L
M
-
R
S
G
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
P
P
F
T
G
E
----
N
R
K
K
T
I
D
K
I
L
K
C
K
L
N
L
P
P
Y
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
R
L
G
A
G
-
P
G
D
A
G
E
-
V
Q
A
H
P
F
F
R
H
I
N
W
E
E
L
L
A
R
K
V
E
P
P
F
K
P
L
L
Q
S
---------------------------------------------------------------------------------------------------------------------------
84
PsiBlast_CBE
46.75
37%
-85
- C1 -
4NUS
1
KS6A3_HUMAN
A:
[30-310]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
Q
F
E
L
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
V
K
----
K
I
-----
S
G
SDAR
Q
L
Y
A
M
K
V
L
K
K
A
T
L
-
K
V
R
-
D
-
R
--
V
R
T
K
M
-
E
R
D
I
L
-
V
E
-
V
-
N
H
---
P
-
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
----
E
V
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
S
L
-
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
G
----
H
I
K
L
T
D
F
G
L
S
K
E
S
I
-
D
H
E
-
K
K
-
A
Y
S
F
C
----
G
T
V
E
Y
M
A
P
E
V
V
N
-
R
R
G
H
T
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
T
L
P
F
Q
G
K
----
D
R
K
E
T
M
T
M
I
L
K
A
K
L
G
M
P
Q
F
L
S
P
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
R
L
G
A
G
-
P
D
G
V
E
E
-
I
K
R
H
S
F
F
S
T
I
D
W
N
K
L
Y
R
R
E
I
H
P
P
F
K
P
A
T
F
Y
F
D
P
------------------------------------------------------------------------------------------------------------------------
83
PsiBlast_CBE
46.41
37%
-85
- C1 -
4NW5
1
KS6A3_HUMAN
A:
[30-310]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
Q
F
E
L
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
V
K
----
K
I
-----
S
G
SDAR
Q
L
Y
A
M
K
V
L
K
K
A
T
L
-
K
V
R
-
D
-
R
--
V
R
T
K
M
-
E
R
D
I
L
-
V
E
-
V
-
N
H
---
P
-
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
----
E
V
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
S
L
-
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
G
----
H
I
K
L
T
D
F
G
L
S
K
E
S
I
-
D
H
E
-
K
K
-
A
Y
S
F
C
----
G
T
V
E
Y
M
A
P
E
V
V
N
-
R
R
G
H
T
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
T
L
P
F
Q
G
K
----
D
R
K
E
T
M
T
M
I
L
K
A
K
L
G
M
P
Q
F
L
S
P
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
R
L
G
A
G
-
P
D
G
V
E
E
-
I
K
R
H
S
F
F
S
T
I
D
W
N
K
L
Y
R
R
E
I
H
P
P
F
K
P
T
F
Y
F
D
P
-------------------------------------------------------------------------------------------------------------------------
60
PsiBlast_CBE
46.38
37%
-88
- C1 -
3A60
1
KS6B1_HUMAN
A:
[19-299]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
L
L
R
V
L
G
K
G
G
Y
G
K
V
F
--
Q
V
---
R
K
V
T
GAN
T
G
----
K
I
F
A
M
K
V
L
K
K
A
M
---------------
K
A
E
R
N
I
L
-
E
E
-
V
-
K
H
---
P
-
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
E
G
--
I
--
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
K
-
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
H
Q
G
----
H
V
K
L
T
D
F
G
L
C
K
E
--------------------
T
I
E
Y
M
A
P
E
I
L
M
-
R
S
G
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
P
P
F
T
G
E
----
N
R
K
K
T
I
D
K
I
L
K
C
K
L
N
L
P
P
Y
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
R
L
G
A
G
-
P
G
D
A
G
E
-
V
Q
A
H
P
F
F
R
H
I
N
W
E
E
L
L
A
R
K
V
E
P
P
F
K
P
-------------------------------------------------------------------------------------------------------------------------------
97
PsiBlast_CBE
46.16
32%
-90
- C1 -
2UZV
1
KAPCA_BOVIN
A:
[27-302]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
---
M
E
-----
T
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
-
V
K
L
-
K
-
Q
--
I
E
H
T
L
N
E
K
R
I
L
-
Q
A
-
V
-
N
F
---
P
-
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
--
R
--
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
----
Y
I
Q
V
T
D
F
G
F
A
K
R
----------
V
K
G
R
T
W
T
LC
G
T
P
E
Y
L
A
P
E
I
I
L
-
S
K
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
----
Q
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
L
-
K
D
G
V
N
D
-
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
---
E
I
R
V
S
I
N
E
K
C
G
K
E
F
S
E
F
------------------------------------------------------------------------------------------
82
PsiBlast_CBE
46.12
37%
-83
- C1 -
4NW6
1
KS6A3_HUMAN
A:
[30-310]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
Q
F
E
L
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
V
K
----
K
I
-----
S
G
SDAR
Q
L
Y
A
M
K
V
L
K
K
A
T
L
-
K
V
R
-
D
-
R
--
V
R
T
K
M
-
E
R
D
I
L
-
V
E
-
V
-
N
H
---
P
-
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
----
E
V
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
S
L
-
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
G
----
H
I
K
L
T
D
F
G
L
S
K
E
S
I
-
D
H
E
-
K
K
-
A
Y
S
F
C
----
G
T
V
E
Y
M
A
P
E
V
V
N
-
R
R
G
H
T
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
T
L
P
F
Q
G
K
----
D
R
K
E
T
M
T
M
I
L
K
A
K
L
G
M
P
Q
F
L
S
P
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
R
L
G
A
G
-
P
D
G
V
E
E
-
I
K
R
H
S
F
F
S
T
I
D
W
N
K
L
Y
R
R
E
I
H
P
P
F
K
P
T
F
Y
F
D
P
-------------------------------------------------------------------------------------------------------------------------
102
PsiBlast_CBE
45.87
31%
-89
- C1 -
2F7Z
1
KAPCA_BOVIN
E:
[16-317]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
K
E
F
L
A
K
A
K
E
D
F
L
K
K
W
E
N
P
A
Q
N
-
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
---
M
E
-----
T
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
-
V
K
L
-
K
-
Q
--
I
E
H
T
L
N
E
K
R
I
L
-
Q
A
-
V
-
N
F
---
P
-
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
--
R
--
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
----
Y
I
Q
V
T
D
F
G
F
A
K
R
----------
V
K
G
R
T
WTLC
G
T
P
E
Y
L
A
P
E
I
I
L
-
S
K
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
----
Q
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
L
-
K
N
G
V
N
D
-
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
---
E
I
R
V
S
I
N
E
K
C
G
K
E
F
S
E
F
------------------------------------------------------------------------------------------
101
PsiBlast_CBE
45.87
31%
-86
- C1 -
2OH0
1
KAPCA_BOVIN
E:
[16-317]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
K
E
F
L
A
K
A
K
E
D
F
L
K
K
W
E
N
P
A
Q
N
-
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
---
M
E
-----
T
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
-
V
K
L
-
K
-
Q
--
I
E
H
T
L
N
E
K
R
I
L
-
Q
A
-
V
-
N
F
---
P
-
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
--
R
--
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
----
Y
I
Q
V
T
D
F
G
F
A
K
R
----------
V
K
G
R
T
WTLC
G
T
P
E
Y
L
A
P
E
I
I
L
-
S
K
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
----
Q
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
L
-
K
N
G
V
N
D
-
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
---
E
I
R
V
S
I
N
E
K
C
G
K
E
F
S
E
F
------------------------------------------------------------------------------------------
136
HHSearch
45.82
37%
-90
- C1 -
3UBD
1
KS6A3_MOUSE
A:
[21-304]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
P
S
Q
F
E
L
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
V
K
K
---
I
S
GSD--
A
R
----
Q
L
Y
A
M
K
V
L
K
K
A
T
L
-
K
V
--
R
-
D
--
R
V
------
D
I
L
-
V
E
-
V
-
N
H
---
P
-
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
----
E
V
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
S
L
-
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
G
----
H
I
K
L
T
D
F
G
L
S
K
-------E
K
K
-
A
Y
S
F
C
----
G
T
V
E
Y
M
A
P
E
V
V
N
-
R
R
G
H
T
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
T
L
P
F
Q
G
K
D
R
----
K
E
T
M
T
M
I
L
K
A
K
L
G
M
P
Q
F
L
S
P
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
R
L
G
A
G
-
P
D
G
V
E
E
-
I
K
R
H
S
F
F
S
T
I
D
W
N
K
L
Y
R
R
E
I
H
P
P
F
K
P
-------------------------------------------------------------------------------------------------------------------------------
100
PsiBlast_CBE
45.81
31%
-82
- C1 -
2OJF
1
KAPCA_BOVIN
E:
[16-317]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
K
E
F
L
A
K
A
K
E
D
F
L
K
K
W
E
N
P
A
Q
N
-
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
---
M
E
-----
T
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
-
V
K
L
-
K
-
Q
--
I
E
H
T
L
N
E
K
R
I
L
-
Q
A
-
V
-
N
F
---
P
-
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
--
R
--
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
----
Y
I
Q
V
T
D
F
G
F
A
K
R
----------
V
K
G
R
T
WTLC
G
T
P
E
Y
L
A
P
E
I
I
L
-
S
K
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
----
Q
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
L
-
K
N
G
V
N
D
-
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
---
E
I
R
V
S
I
N
E
K
C
G
K
E
F
S
E
F
------------------------------------------------------------------------------------------
73
PsiBlast_CBE
45.66
38%
-101
- C1 -
2Z7Q
1
KS6A1_HUMAN
A:
[30-308]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
L
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
V
R
K
---
V
T
RPD--
S
G
----
H
L
Y
A
M
K
V
L
------------------------
I
L
-
A
D
-
V
-
N
H
---
P
-
F
V
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
----
E
V
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
G
L
D
H
L
H
S
L
-
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
G
----
H
I
K
L
T
D
F
G
L
S
K
E
-------------------
G
T
V
E
Y
M
A
P
E
V
V
N
-
R
Q
G
H
S
H
S
A
D
W
W
S
Y
G
V
L
M
F
E
M
L
T
G
S
L
P
F
Q
G
K
----
D
R
K
E
T
M
T
L
I
L
K
A
K
L
G
M
P
Q
F
L
S
T
E
A
Q
S
L
L
R
A
L
F
K
R
N
P
A
N
R
L
G
S
G
-
P
D
G
A
E
E
-
I
K
R
H
V
F
Y
S
T
I
D
W
N
K
L
Y
R
R
E
I
K
P
P
F
K
P
-------------------------------------------------------------------------------------------------------------------------------
63
PsiBlast_CBE
45.46
39%
-93
- C1 -
4L3J
1
KS6B1_HUMAN
A:
[20-300]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
L
L
R
V
L
G
K
G
G
Y
G
K
V
F
--
Q
V
---
R
K
VTGAN
T
G
----
K
I
F
A
M
K
V
L
K
K
A
M
I
V
R
N
A
-
K
-
D
--
T
A
H
T
K
A
E
R
N
I
L
-
E
E
-
V
-
K
H
---
P
-
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
E
G
--
I
--
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
K
-
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
H
Q
G
----
H
V
K
L
T
D
F
G
L
C
K
E
S
I
-
H
D
G
-
T
V
-
T
H
T
F
C
----
G
T
I
E
Y
M
A
P
E
I
L
M
-
R
S
G
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
P
P
F
T
G
E
----
N
R
K
K
T
I
D
K
I
L
K
C
K
L
N
L
P
P
Y
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
R
L
G
A
G
-
P
G
D
A
G
E
-
V
Q
A
H
P
F
F
R
H
I
N
W
E
E
L
L
A
R
K
V
E
P
P
F
K
P
L
L
Q
S
---------------------------------------------------------------------------------------------------------------------------
77
PsiBlast_CBE
45.15
38%
-97
- C1 -
2R5T
1
SGK1_HUMAN
A:
[40-317]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
H
F
L
K
V
I
G
K
G
S
F
G
K
V
L
L
A
R
H
---
K
A
-----
E
E
----
V
F
Y
A
V
K
V
L
Q
K
K
A
I
-
L
-----------------
V
L
-
L
K
N
V
-
K
H
---
P
-
F
L
V
G
L
H
F
S
F
Q
T
A
D
K
L
Y
F
V
L
D
Y
I
N
G
G
E
L
F
Y
H
L
--
Q
R
--
E
R
C
F
L
E
P
R
A
R
F
Y
A
A
E
I
A
S
A
L
G
Y
L
H
S
L
-
N
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
S
Q
G
----
H
I
V
L
T
D
F
G
L
C
K
E
N
I
-
E
H
N
-
S
T
-
T
S
T
F
C
----
G
T
P
E
Y
L
A
P
E
V
L
H
-
K
Q
P
Y
D
R
T
V
D
W
W
C
L
G
A
V
L
Y
E
M
L
Y
G
L
P
P
F
Y
S
R
N
T
A
E
M
Y
D
N
I
L
N
K
P
L
Q
L
K
P
----
N
I
T
N
S
A
R
H
L
L
E
G
L
L
Q
K
D
R
T
K
R
L
G
A
K
-
D
D
-
F
M
E
-
I
K
S
H
V
F
F
S
L
I
N
W
D
D
L
I
N
K
K
I
T
P
P
F
N
P
N
V
S
G
---------------------------------------------------------------------------------------------------------------------------
86
PsiBlast_CBE
44.76
37%
-88
- C1 -
4EL9
1
KS6A3_MOUSE
A:
[25-305]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
Q
F
E
L
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
V
K
----
K
I
-----
S
G
SDAR
Q
L
Y
A
M
K
V
L
K
K
A
T
L
-
K
V
R
-
D
-
R
--
V
R
------
D
I
L
-
V
E
-
V
-
N
H
---
P
-
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
----
E
V
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
S
L
-
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
G
----
H
I
K
L
T
D
F
G
L
S
K
E
S----
E
-
K
K
-
A
Y
S
F
C
----
G
T
V
E
Y
M
A
P
E
V
V
N
-
R
R
G
H
T
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
T
L
P
F
Q
G
K
----
D
R
K
E
T
M
T
M
I
L
K
A
K
L
G
M
P
Q
F
L
S
P
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
R
L
G
A
G
-
P
D
G
V
E
E
-
I
K
R
H
S
F
F
S
T
I
D
W
N
K
L
Y
R
R
E
I
H
P
P
F
K
P
-------------------------------------------------------------------------------------------------------------------------------
72
PsiBlast_CBE
44.53
38%
-90
- C1 -
2Z7R
1
KS6A1_HUMAN
A:
[30-308]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
L
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
V
R
K
---
V
T
RPD--
S
G
----
H
L
Y
A
M
K
V
L
K
K
A
T
L
-
K
V
----------------
I
L
-
A
D
-
V
-
N
H
---
P
-
F
V
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
----
E
V
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
G
L
D
H
L
H
S
L
-
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
G
----
H
I
K
L
T
D
F
G
L
S
K
E
-------------------
G
T
V
E
Y
M
A
P
E
V
V
N
-
R
Q
G
H
S
H
S
A
D
W
W
S
Y
G
V
L
M
F
E
M
L
T
G
S
L
P
F
Q
G
K
----
D
R
K
E
T
M
T
L
I
L
K
A
K
L
G
M
P
Q
F
L
S
T
E
A
Q
S
L
L
R
A
L
F
K
R
N
P
A
N
R
L
G
S
G
-
P
D
G
A
E
E
-
I
K
R
H
V
F
Y
S
T
I
D
W
N
K
L
Y
R
R
E
I
K
P
P
F
K
P
-------------------------------------------------------------------------------------------------------------------------------
87
PsiBlast_CBE
44.42
37%
-88
- C1 -
3UBD
1
KS6A3_MOUSE
A:
[24-304]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
Q
F
E
L
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
V
K
----
K
I
-----
S
G
SDAR
Q
L
Y
A
M
K
V
L
K
K
A
T
L
-
K
V
R
-
D
-
R
--
V
-------
D
I
L
-
V
E
-
V
-
N
H
---
P
-
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
----
E
V
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
S
L
-
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
G
----
H
I
K
L
T
D
F
G
L
S
K
E
-------
K
K
-
A
Y
S
F
C
----
G
T
V
E
Y
M
A
P
E
V
V
N
-
R
R
G
H
T
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
T
L
P
F
Q
G
K
----
D
R
K
E
T
M
T
M
I
L
K
A
K
L
G
M
P
Q
F
L
S
P
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
R
L
G
A
G
-
P
D
G
V
E
E
-
I
K
R
H
S
F
F
S
T
I
D
W
N
K
L
Y
R
R
E
I
H
P
P
F
K
P
-------------------------------------------------------------------------------------------------------------------------------
85
PsiBlast_CBE
44.37
37%
-85
- C1 -
4GUE
1
KS6A3_MOUSE
A:
[25-305]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
Q
F
E
L
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
V
K
----
K
I
-----
S
G
SDAR
Q
L
Y
A
M
K
V
L
K
K
A
T
L
-
K
V
R
-
D
-
R
--
V
---------
L
-
V
E
-
V
-
N
H
---
P
-
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
----
E
V
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
S
L
-
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
G
----
H
I
K
L
T
D
F
G
L
S
K
E
-------
K
K
-
A
Y
S
F
C
----
G
T
V
E
Y
M
A
P
E
V
V
N
-
R
R
G
H
T
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
T
L
P
F
Q
G
K
----
D
R
K
E
T
M
T
M
I
L
K
A
K
L
G
M
P
Q
F
L
S
P
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
R
L
G
A
G
-
P
D
G
V
E
E
-
I
K
R
H
S
F
F
S
T
I
D
W
N
K
L
Y
R
R
E
I
H
P
P
F
K
P
-------------------------------------------------------------------------------------------------------------------------------
59
PsiBlast_CBE
44.21
37%
-93
- C1 -
3A60
1
KS6B1_HUMAN
B:
[19-300]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
L
L
R
V
L
G
K
G
G
Y
G
K
V
F
--
Q
V
---
R
K
VTGAN
T
G
----
K
I
F
A
M
K
V
L
K
K
------------------------------
K
H
---
P
-
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
E
G
--
I
--
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
K
-
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
H
Q
G
----
H
V
K
L
T
D
F
G
L
C
K
E
S-------------
C
----
G
T
I
E
Y
M
A
P
E
I
L
M
-
R
S
G
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
P
P
F
T
G
E
----
N
R
K
K
T
I
D
K
I
L
K
C
K
L
N
L
P
P
Y
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
R
L
G
A
G
-
P
G
D
A
G
E
-
V
Q
A
H
P
F
F
R
H
I
N
W
E
E
L
L
A
R
K
V
E
P
P
F
K
P
-----
L
-------------------------------------------------------------------------------------------------------------------------
64
PsiBlast_CBE
44.16
39%
-97
- C1 -
4RLO
4
KS6B1_HUMAN
B:
[7-287]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
L
L
R
V
L
G
K
G
G
Y
G
K
V
F
--
Q
V
---
R
K
VTGAN
T
G
----
K
I
F
A
M
K
V
L
K
K
------------------------------
K
H
---
P
-
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
E
G
--
I
--
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
K
-
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
H
Q
G
----
H
V
K
L
T
D
F
G
L
C
K
E
S
I
------------------
T
I
E
Y
M
A
P
E
I
L
M
-
R
S
G
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
P
P
F
T
G
E
----
N
R
K
K
T
I
D
K
I
L
K
C
K
L
N
L
P
P
Y
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
R
L
G
A
G
-
P
G
D
A
G
E
-
V
Q
A
H
P
F
F
R
H
I
N
W
E
E
L
L
A
R
K
V
E
P
P
F
K
P
L
------------------------------------------------------------------------------------------------------------------------------
75
PsiBlast_CBE
43.60
38%
-90
- C1 -
3HDN
1
SGK1_HUMAN
A:
[40-316]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
H
F
L
K
V
I
G
K
G
S
F
G
K
V
L
L
A
R
H
---
K
A
-----
E
E
----
V
F
Y
A
V
K
V
L
Q
K
K
A
I
-
L
-----------------
V
L
-
L
K
N
V
-
K
H
---
P
-
F
L
V
G
L
H
F
S
F
Q
T
A
D
K
L
Y
F
V
L
D
Y
I
N
G
G
E
L
F
Y
H
L
--
Q
R
--
E
R
C
F
L
E
P
R
A
R
F
Y
A
A
E
I
A
S
A
L
G
Y
L
H
S
L
-
N
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
S
Q
G
----
H
I
V
L
T
D
F
G
L
C
K
E
N
I
-
E
H
N
-
S
T
-
T
S
T
F
C
----
G
T
P
E
Y
L
A
P
E
V
L
H
-
K
Q
P
Y
D
R
T
V
D
W
W
C
L
G
A
V
L
Y
E
M
L
Y
G
L
P
P
F
Y
S
R
N
T
A
E
M
Y
D
N
I
L
N
K
P
L
Q
L
K
P
----
N
I
T
N
S
A
R
H
L
L
E
G
L
L
Q
K
D
R
T
K
R
L
G
A
K
-
D
D
-
F
M
E
-
I
K
S
H
V
F
F
S
L
I
N
W
D
D
L
I
N
K
K
I
T
P
P
F
N
P
-------------------------------------------------------------------------------------------------------------------------------
76
PsiBlast_CBE
43.14
38%
-86
- C1 -
3HDM
1
SGK1_HUMAN
A:
[40-317]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
H
F
L
K
V
I
G
K
G
S
F
G
K
V
L
L
A
R
H
---
K
A
-----
E
E
----
V
F
Y
A
V
K
V
L
Q
K
K
A
I
-
L
-----------------
V
L
-
L
K
N
V
-
K
H
---
P
-
F
L
V
G
L
H
F
S
F
Q
T
A
D
K
L
Y
F
V
L
D
Y
I
N
G
G
E
L
F
Y
H
L
--
Q
R
--
E
R
C
F
L
E
P
R
A
R
F
Y
A
A
E
I
A
S
A
L
G
Y
L
H
S
L
-
N
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
S
Q
G
----
H
I
V
L
T
D
F
G
L
C
K
E
N
I
-
E
H
N
-
S
T
-
T
S
T
F
C
----
G
T
P
E
Y
L
A
P
E
V
L
H
-
K
Q
P
Y
D
R
T
V
D
W
W
C
L
G
A
V
L
Y
E
M
L
Y
G
L
P
P
F
Y
S
R
N
T
A
E
M
Y
D
N
I
L
N
K
P
L
Q
L
K
P
----
N
I
T
N
S
A
R
H
L
L
E
G
L
L
Q
K
D
R
T
K
R
L
G
A
K
-
D
D
-
F
M
E
-
I
K
S
H
V
F
F
S
L
I
N
W
D
D
L
I
N
K
K
I
T
P
P
F
N
P
N
V
S
G
---------------------------------------------------------------------------------------------------------------------------
134
HHSearch
38.02
32%
-76
- C1 -
2Y0A
1
DAPK1_HUMAN
A:
[10-284]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
Y
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
---
K
S
-----
T
G
----
L
Q
Y
A
A
K
F
I
K
K
R
R
T
-
K
S
S
-
R
R
G
VS
R
E
D
I
E
R
E
V
S
I
L
-
K
E
-
I
-
Q
H
---
P
-
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
----
K
E
S
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
-
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
VP
K
P
R
I
K
I
I
D
F
G
L
A
H
K
-
I
-
D
F
G
-
N
E
-
F
K
N
I
F
----
G
T
P
E
F
V
A
P
E
I
V
N
-
Y
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
K
Q
E
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
------
I
Q
D
-
S
L
Q
H
P
W
I
K
P
K
D
T
Q
Q
A
L
S
R
K
A
S
A
V
N
M
E
K
F
K
K
F
A
A
R
-----------------------------------------------------------------------------------------------------------------------