@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : GRK6_HUMAN: (2015-10-08 )
MELENIVANTVLLKAREGGGGNRKGKSKKWRQMLQFPHISQCEELRLSLERDYHSLCERQPIGRLLFREFCATRPELSRCVAFLDGVAEYEVTPDDKRKACGRQLTQNFLSHTGPDLIPEVPRQLVTNCTQRLEQGPCKDLFQELTRLTHEYLSVAPFADYLDSIYFNRFLQWKWLERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTIKGRVGTVGYMAPEVVKNERYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYSERFSPQARSLCSQLLCKDPAERLGCRGGSAREVKEHPLFKKLNFKRLGAGMLEPPFKPDPQAIYCKDVLDIEQFSTVKGVELEPTDQDFYQKFATGSVPIPWQNEMVETECFQELNVFGLDGSVPPDLDWKGQPPAPPKKGLLQRLFSRQDCCGNCSDSEEELPTRL
Atome Classification :
(71 SA)
.........10.......--.20........30........40........50........---60........70........-80........90-........100.......110-----...-......120.......130.-......-----140.......150.......160.......170.......-180.......190.......200...---..-----..----210.......220-..-..---...230......-.240-...---.....250.......260.......270.......--280..-.......290.......300.......310.......320.----......330---...-.-...340-.....----...350.....-..360.......370.......380..-.....-390.......400.----......410.......420.......430...-.-...440.......450.......460.......470.......480..---.....490.......500.......510.......520.......530.......540.......550.......560.......570....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
E
L
E
N
I
VAN
T
V
L
L
K
A
REG--GGGNRKGK
S
K
K
W
R
Q
M
LQFPH
I
S
Q
C
E
E
L
R
L
S
L
E
R
D
Y
H
S
L
C
ER---Q
P
I
G
R
L
L
F
R
E
F
CAT
R
P
E
L
S
R
-
C
V
A
F
L
D
G
V
AEYE-VT
P
D
D
K
R
K
A
C
G
R
Q
L
T
Q
N
F
L
-------SHT-G
P
D
L
I
P
E
V
P
R
Q
L
V
T
N
C
T
Q
R
L-EQG
P
C
K
-----
D
L
F
Q
E
L
T
R
L
T
H
E
Y
LSV
A
P
F
A
D
Y
L
D
S
I
Y
F
N
R
F
L
Q
W
K
W
LERQ-PV
T
K
N
T
F
R
Q
Y
R
V
LGKGGFG
E
V
C
A
C
Q
V
---RA-----TG----
K
M
Y
A
C
K
K
L
E
K
K
R
I
-
K
K
-RK---GEAMAL
N
E
K
Q
I
L
-
E
K
-V-NS
R
---
F
V
V
S
L
A
Y
A
YETKD
A
L
C
L
V
L
T
LMNGG
D
L
K
F
H
I
Y
HMG--Q--AG-F
P
E
A
R
A
V
F
Y
A
A
E
I
CC
G
L
E
D
L
H
R
E
R
I
V
Y
RDLKPE
N
I
L
LDDHG----
H
I
R
I
S
D
L
G
L
---
A
V
H-V-PEG
Q
-
T
-IKGRV----GTVGYM
A
P
E
V
V-KNE
R
Y
T
FS
P
D
W
W
A
L
G
C
L
L
Y
E
M
IAGQS
P
-
F
Q
Q
R
K
-
K
K
I
K
R
E
E
V
E
R
L
V
K
E
----
V
P
E
E
Y
S
E
RF
S
P
Q
A
R
S
L
C
S
Q
L
L
CKD
P
A
E
R
LGCR-G-GS
A
R
E
V
K
EHP
L
F
K
KL
N
F
K
R
LGAGMLEPPFKPDP
Q
A
I
Y
C
K
D
VL
D
I
E
Q
FS---TVKGVELEPT
D
Q
D
F
Y
Q
K
FATGSVPIPWQNEM
V
E
T
E
C
F
Q
E
L
NVFGLDGSVPPDLDWKGQPPAP
P
K
K
G
L
L
Q
R
L
F
S
RQDCCGNCSD
S
E
E
ELPTRL
95
Fugue
94.01
98%
-112
- C1 -
2ACX
1
GRK6_HUMAN
A:
[14-532]
----------------------
K
A
R
K
G
K
S
K
K
W
R
Q
M
L
Q
F
P
H
I
S
Q
C
E
E
L
R
L
S
L
E
R
D
Y
H
S
L
C
E
R
---
N
P
I
G
R
L
L
F
R
E
F
C
A
T
R
P
E
L
S
R
-
C
V
A
F
L
D
G
V
A
E
Y
E
-
V
T
P
D
D
K
R
K
A
C
G
R
N
L
T
Q
N
F
L
-------
S
H
T
-
G
P
D
L
I
P
E
V
P
R
Q
L
V
T
N
C
T
Q
R
L
-
E
Q
G
P
C
K
-----
D
L
F
Q
E
L
T
R
L
T
H
E
Y
L
S
V
A
P
F
A
D
Y
L
D
S
I
Y
F
N
R
F
L
Q
W
K
W
L
E
R
Q
-
P
V
T
K
N
T
F
R
Q
Y
R
V
L
G
K
G
G
F
G
E
V
C
A
C
Q
V
---
R
A
-----
T
G
----
K
M
Y
A
C
K
K
L
E
K
K
R
I
-
K
K
-
R
K
---
G
E
A
M
A
L
N
E
K
Q
I
L
-
E
K
-
V
-
N
S
R
---
F
V
V
S
L
A
Y
A
Y
E
T
K
D
A
L
C
L
V
L
T
L
M
N
G
G
D
L
K
F
H
I
Y
H
M
G
--
Q
--
A
G
-
F
P
E
A
R
A
V
F
Y
A
A
E
I
C
C
G
L
E
D
L
H
R
E
R
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
D
H
G
----
H
I
R
I
S
D
L
G
L
---
A
V
H
-
V
-
P
E
G
Q
-
T
-
I
K
G
R
V
----
G
T
V
G
Y
M
A
P
E
V
V
-
K
N
E
R
Y
T
F
S
P
D
W
W
A
L
G
C
L
L
Y
E
M
I
A
G
Q
S
P
-
F
Q
Q
R
K
-
K
K
I
K
R
E
E
V
E
R
L
V
K
E
----
V
P
E
E
Y
S
E
R
F
S
P
Q
A
R
S
L
C
S
Q
L
L
C
K
D
P
A
E
R
L
G
C
R
-
G
-
G
S
A
R
E
V
K
E
H
P
L
F
K
K
L
N
F
K
R
L
G
A
G
M
L
E
P
P
F
K
P
D
P
--------------------
Q
A
I
Y
C
E
P
T
D
Q
D
F
Y
Q
K
F
A
T
G
S
V
P
I
P
W
Q
N
E
M
V
E
T
E
C
F
Q
E
L
N
V
F
G
L
D
G
S
--------------------------------------------
102
HHSearch
94.00
99%
-113
- C1 -
2ACX
1
GRK6_HUMAN
A:
[14-532]
-------------
K
A
R
---------
K
G
K
S
K
K
W
R
Q
M
L
Q
F
P
H
I
S
Q
C
E
E
L
R
L
S
L
E
R
D
Y
H
S
L
C
E
R
---
N
P
I
G
R
L
L
F
R
E
F
C
A
T
R
P
E
L
S
R
-
C
V
A
F
L
D
G
V
A
E
Y
E
-
V
T
P
D
D
K
R
K
A
C
G
R
N
L
T
Q
N
F
L
-------
S
H
T
-
G
P
D
L
I
P
E
V
P
R
Q
L
V
T
N
C
T
Q
R
L
-
E
Q
G
P
C
K
-----
D
L
F
Q
E
L
T
R
L
T
H
E
Y
L
S
V
A
P
F
A
D
Y
L
D
S
I
Y
F
N
R
F
L
Q
W
K
W
L
E
R
Q
-
P
V
T
K
N
T
F
R
Q
Y
R
V
L
G
K
G
G
F
G
E
V
C
A
C
Q
V
---
R
A
-----
T
G
----
K
M
Y
A
C
K
K
L
E
K
K
R
I
-
K
K
-
R
K
---
G
E
A
M
A
L
N
E
K
Q
I
L
-
E
K
-
V
-
N
S
R
---
F
V
V
S
L
A
Y
A
Y
E
T
K
D
A
L
C
L
V
L
T
L
M
N
G
G
D
L
K
F
H
I
Y
H
M
G
--
Q
--
A
G
-
F
P
E
A
R
A
V
F
Y
A
A
E
I
C
C
G
L
E
D
L
H
R
E
R
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
D
H
G
----
H
I
R
I
S
D
L
G
L
---
A
V
H
-
V
-
P
E
G
Q
-
T
-
I
K
G
R
V
----
G
T
V
G
Y
M
A
P
E
V
V
-
K
N
E
R
Y
T
F
S
P
D
W
W
A
L
G
C
L
L
Y
E
M
I
A
G
Q
S
P
-
F
Q
Q
R
K
-
K
K
I
K
R
E
E
V
E
R
L
V
K
E
----
V
P
E
E
Y
S
E
R
F
S
P
Q
A
R
S
L
C
S
Q
L
L
C
K
D
P
A
E
R
L
G
C
R
-
G
-
G
S
A
R
E
V
K
E
H
P
L
F
K
K
L
N
F
K
R
L
G
A
G
M
L
E
P
P
F
K
P
D
P
Q
A
I
Y
C
--------------------
E
P
T
D
Q
D
F
Y
Q
K
F
A
T
G
S
V
P
I
P
W
Q
N
E
M
V
E
T
E
C
F
Q
E
L
N
V
F
G
L
D
G
S
--------------------------------------------
3
PsiBlast_PDB
94.00
99%
-113
- C1 -
2ACX
1
GRK6_HUMAN
A:
[14-532]
-------------
K
A
R
---------
K
G
K
S
K
K
W
R
Q
M
L
Q
F
P
H
I
S
Q
C
E
E
L
R
L
S
L
E
R
D
Y
H
S
L
C
E
R
---
N
P
I
G
R
L
L
F
R
E
F
C
A
T
R
P
E
L
S
R
-
C
V
A
F
L
D
G
V
A
E
Y
E
-
V
T
P
D
D
K
R
K
A
C
G
R
N
L
T
Q
N
F
L
-------
S
H
T
-
G
P
D
L
I
P
E
V
P
R
Q
L
V
T
N
C
T
Q
R
L
-
E
Q
G
P
C
K
-----
D
L
F
Q
E
L
T
R
L
T
H
E
Y
L
S
V
A
P
F
A
D
Y
L
D
S
I
Y
F
N
R
F
L
Q
W
K
W
L
E
R
Q
-
P
V
T
K
N
T
F
R
Q
Y
R
V
L
G
K
G
G
F
G
E
V
C
A
C
Q
V
---
R
A
-----
T
G
----
K
M
Y
A
C
K
K
L
E
K
K
R
I
-
K
K
-
R
K
---
G
E
A
M
A
L
N
E
K
Q
I
L
-
E
K
-
V
-
N
S
R
---
F
V
V
S
L
A
Y
A
Y
E
T
K
D
A
L
C
L
V
L
T
L
M
N
G
G
D
L
K
F
H
I
Y
H
M
G
--
Q
--
A
G
-
F
P
E
A
R
A
V
F
Y
A
A
E
I
C
C
G
L
E
D
L
H
R
E
R
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
D
H
G
----
H
I
R
I
S
D
L
G
L
---
A
V
H
-
V
-
P
E
G
Q
-
T
-
I
K
G
R
V
----
G
T
V
G
Y
M
A
P
E
V
V
-
K
N
E
R
Y
T
F
S
P
D
W
W
A
L
G
C
L
L
Y
E
M
I
A
G
Q
S
P
-
F
Q
Q
R
K
-
K
K
I
K
R
E
E
V
E
R
L
V
K
E
----
V
P
E
E
Y
S
E
R
F
S
P
Q
A
R
S
L
C
S
Q
L
L
C
K
D
P
A
E
R
L
G
C
R
-
G
-
G
S
A
R
E
V
K
E
H
P
L
F
K
K
L
N
F
K
R
L
G
A
G
M
L
E
P
P
F
K
P
D
P
Q
A
I
Y
C
--------------------
E
P
T
D
Q
D
F
Y
Q
K
F
A
T
G
S
V
P
I
P
W
Q
N
E
M
V
E
T
E
C
F
Q
E
L
N
V
F
G
L
D
G
S
--------------------------------------------
23
PsiBlast_CBE
93.96
99%
-114
- C1 -
2ACX
1
GRK6_HUMAN
B:
[14-535]
-------------
K
A
R
---------
K
G
K
S
K
K
W
R
Q
M
L
Q
F
P
H
I
S
Q
C
E
E
L
R
L
S
L
E
R
D
Y
H
S
L
C
E
R
---
N
P
I
G
R
L
L
F
R
E
F
C
A
T
R
P
E
L
S
R
-
C
V
A
F
L
D
G
V
A
E
Y
E
-
V
T
P
D
D
K
R
K
A
C
G
R
N
L
T
Q
N
F
L
-------
S
H
T
-
G
P
D
L
I
P
E
V
P
R
Q
L
V
T
N
C
T
Q
R
L
-
E
Q
G
P
C
K
-----
D
L
F
Q
E
L
T
R
L
T
H
E
Y
L
S
V
A
P
F
A
D
Y
L
D
S
I
Y
F
N
R
F
L
Q
W
K
W
L
E
R
Q
-
P
V
T
K
N
T
F
R
Q
Y
R
V
L
G
K
G
G
F
G
E
V
C
A
C
Q
V
---
R
A
-----
T
G
----
K
M
Y
A
C
K
K
L
E
K
K
R
I
-
K
K
-
R
K
---
G
E
A
M
A
L
N
E
K
Q
I
L
-
E
K
-
V
-
N
S
R
---
F
V
V
S
L
A
Y
A
Y
E
T
K
D
A
L
C
L
V
L
T
L
M
N
G
G
D
L
K
F
H
I
Y
H
M
------
A
G
-
F
P
E
A
R
A
V
F
Y
A
A
E
I
C
C
G
L
E
D
L
H
R
E
R
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
D
H
G
----
H
I
R
I
S
D
L
G
L
---
A
V
H
-
V
-
P
E
G
Q
-
T
-
I
K
G
R
V
----
G
T
V
G
Y
M
A
P
E
V
V
-
K
N
E
R
Y
T
F
S
P
D
W
W
A
L
G
C
L
L
Y
E
M
I
A
G
Q
S
P
-
F
Q
Q
----
K
I
K
R
E
E
V
E
R
L
V
K
E
----
V
P
E
E
Y
S
E
R
F
S
P
Q
A
R
S
L
C
S
Q
L
L
C
K
D
P
A
E
R
L
G
C
R
-
G
-
G
S
A
R
E
V
K
E
H
P
L
F
K
K
L
N
F
K
R
L
G
A
G
M
L
E
P
P
F
K
P
D
P
Q
A
I
Y
---------------------
E
P
T
D
Q
D
F
Y
Q
K
F
A
T
G
S
V
P
I
P
W
Q
N
E
M
V
E
T
E
C
F
Q
E
L
N
V
F
G
L
D
G
S
V
P
P
-----------------------------------------
4
PsiBlast_PDB
87.47
72%
-109
- C1 -
4WNK
1
GRK5_BOVIN
A:
[24-541]
-------------------------
K
G
K
S
K
K
W
K
E
I
L
K
F
P
H
I
N
Q
C
E
D
L
R
R
T
I
D
R
D
Y
C
S
L
C
D
K
---
Q
P
V
G
R
L
L
F
R
Q
F
C
E
T
R
P
G
L
E
S
-
Y
I
Q
F
L
D
S
V
A
E
Y
E
-
V
T
P
D
E
K
L
G
E
K
G
K
E
I
M
T
K
Y
L
-------
T
P
K
-
S
P
V
F
I
T
Q
V
G
R
D
L
V
S
Q
T
E
E
K
L
-
L
Q
K
P
C
K
-----
E
L
F
S
A
C
V
Q
S
V
H
D
Y
L
R
G
E
P
F
H
E
Y
L
D
S
M
Y
F
D
R
F
L
Q
W
K
W
L
E
R
Q
-
P
V
T
K
N
T
F
R
Q
Y
R
V
L
G
K
G
G
F
G
E
V
C
A
C
Q
V
---
R
A
-----
T
G
----
K
M
Y
A
C
K
R
L
E
K
K
R
I
-
K
K
-
R
K
---
G
E
S
M
A
L
N
E
K
Q
I
L
-
E
K
-
V
-
N
S
R
---
F
V
V
N
L
A
Y
A
Y
E
T
K
D
A
L
C
L
V
L
T
I
M
N
G
G
D
L
K
F
H
I
Y
N
M
G
--
N
--
P
G
-
F
E
E
E
R
A
L
F
Y
A
A
E
I
L
C
G
L
E
D
L
H
H
E
N
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
D
Y
G
----
H
I
R
I
S
D
L
G
L
---
A
V
K
-
I
-
P
E
G
D
-
L
-
I
R
G
R
V
----
G
T
V
G
Y
M
A
P
E
V
L
-
N
N
Q
R
Y
G
L
S
P
D
Y
W
G
L
G
C
L
I
Y
E
M
I
E
G
Q
S
P
-
F
R
G
R
K
-
E
K
V
K
R
E
E
V
D
R
R
V
L
E
----
T
E
E
V
Y
S
H
K
F
S
E
E
A
K
S
I
C
K
M
L
L
T
K
D
A
K
Q
R
L
G
C
Q
-
E
-
E
G
A
A
E
V
K
R
H
P
F
F
R
N
M
N
F
K
R
L
E
A
G
M
L
D
P
P
F
V
P
D
P
R
A
V
Y
----------------------
H
T
D
D
D
F
Y
S
K
F
S
T
G
S
V
P
I
P
W
Q
S
E
M
I
E
T
E
C
F
K
E
L
N
V
F
G
P
H
G
T
L
S
P
D
L
N
-
R
S
H
----------------------------------
5
PsiBlast_PDB
85.95
72%
-100
- C1 -
4TNB
1
GRK5_HUMAN
A:
[15-543]
--------------
A
R
E
G
--
G
G
G
K
R
K
G
K
S
K
K
W
K
E
I
L
K
F
P
H
I
S
Q
C
E
D
L
R
R
T
I
D
R
D
Y
C
S
L
C
D
K
---
Q
P
I
G
R
L
L
F
R
Q
F
C
E
T
R
P
G
L
E
C
-
Y
I
Q
F
L
D
S
V
A
E
Y
E
-
V
T
P
D
E
K
L
G
E
K
G
K
K
I
M
T
K
Y
L
-------
T
P
K
-
S
P
V
F
I
A
Q
V
G
Q
D
L
V
S
Q
T
E
E
K
L
-
L
Q
K
P
C
K
-----
E
L
F
S
A
C
A
Q
S
V
H
E
Y
L
R
G
E
P
F
H
E
Y
L
D
S
M
F
F
D
R
F
L
Q
W
K
W
L
E
R
Q
-
P
V
T
K
N
T
F
R
Q
Y
R
V
L
G
K
G
G
F
G
E
V
C
A
C
Q
V
---
R
A
-----
T
G
----
K
M
Y
A
C
K
R
L
E
K
K
R
I
-
K
K
-
R
K
---
G
E
S
M
A
L
N
E
K
Q
I
L
-
E
K
-
V
-
N
S
Q
---
F
V
V
N
L
A
Y
A
Y
E
T
K
D
A
L
C
L
V
L
T
I
M
N
G
G
D
L
K
F
H
I
Y
N
M
G
--
N
--
P
G
-
F
E
E
E
R
A
L
F
Y
A
A
E
I
L
C
G
L
E
D
L
H
H
E
N
T
V
Y
R
D
L
K
P
E
N
I
L
L
D
D
Y
G
----
H
I
R
I
S
D
L
G
L
---
A
V
K
-
I
-
P
E
G
D
-
L
-
I
R
G
R
V
----
G
T
V
G
Y
M
A
P
E
V
L
-
N
N
Q
R
Y
G
L
S
P
D
Y
W
G
L
G
C
L
I
Y
E
M
I
E
G
Q
S
P
-
F
R
G
R
K
-
E
K
V
K
R
E
E
V
D
R
R
V
L
E
----
T
E
E
V
Y
S
H
K
F
S
E
E
A
K
S
I
C
K
M
L
L
T
K
D
A
K
Q
R
L
G
C
Q
-
E
-
E
E
A
A
E
V
K
R
H
P
F
F
R
N
M
N
F
K
R
L
E
A
G
M
L
D
P
P
F
V
P
D
P
R
A
V
Y
C
K
D
V
L
D
I
E
Q
F
S
---
T
V
K
G
V
N
L
D
H
T
D
D
D
F
Y
S
K
F
S
T
G
S
V
S
I
P
W
Q
N
E
M
I
E
T
E
C
F
K
E
L
N
V
F
G
P
N
G
T
L
P
P
D
L
N
-
R
N
H
P
P
--------------------------------
6
PsiBlast_PDB
85.74
72%
-99
- C1 -
4TND
1
GRK5_HUMAN
A:
[15-543]
--------------
A
R
E
G
--
G
G
G
K
R
K
G
K
S
K
K
W
K
E
I
L
K
F
P
H
I
S
Q
C
E
D
L
R
R
T
I
D
R
D
Y
C
S
L
C
D
K
---
Q
P
I
G
R
L
L
F
R
Q
F
C
E
T
R
P
G
L
E
C
-
Y
I
Q
F
L
D
S
V
A
E
Y
E
-
V
T
P
D
E
K
L
G
E
K
G
K
K
I
M
T
K
Y
L
-------
T
P
K
-
S
P
V
F
I
A
Q
V
G
Q
D
L
V
S
Q
T
E
E
K
L
-
L
Q
K
P
C
K
-----
E
L
F
S
A
C
A
Q
S
V
H
E
Y
L
R
G
E
P
F
H
E
Y
L
D
S
M
F
F
D
R
F
L
Q
W
K
W
L
E
R
Q
-
P
V
T
K
N
T
F
R
Q
Y
R
V
L
G
K
G
G
F
G
E
V
C
A
C
Q
V
---
R
A
-----
T
G
----
K
M
Y
A
C
K
R
L
E
K
K
R
I
-
K
K
-
R
K
---
G
E
S
M
A
L
N
E
K
Q
I
L
-
E
K
-
V
-
N
S
Q
---
F
V
V
N
L
A
Y
A
Y
E
T
K
D
A
L
C
L
V
L
T
I
M
N
G
G
D
L
K
F
H
I
Y
N
M
G
--
N
--
P
G
-
F
E
E
E
R
A
L
F
Y
A
A
E
I
L
C
G
L
E
D
L
H
H
E
N
T
V
Y
R
D
L
K
P
E
N
I
L
L
D
D
Y
G
----
H
I
R
I
S
D
L
G
L
---
A
V
K
-
I
-
P
E
G
D
-
L
-
I
R
G
R
V
----
G
T
V
G
Y
M
A
P
E
V
L
-
N
N
Q
R
Y
G
L
S
P
D
Y
W
G
L
G
C
L
I
Y
E
M
I
E
G
Q
S
P
-
F
R
G
R
K
-
E
K
V
K
R
E
E
V
D
R
R
V
L
E
----
T
E
E
V
Y
S
H
K
F
S
E
E
A
K
S
I
C
K
M
L
L
T
K
D
A
K
Q
R
L
G
C
Q
-
E
-
E
E
A
A
E
V
K
R
H
P
F
F
R
N
M
N
F
K
R
L
E
A
G
M
L
D
P
P
F
V
P
D
P
R
A
V
Y
C
K
D
V
L
D
I
E
Q
F
S
---
T
V
K
G
V
N
L
D
H
T
D
D
D
F
Y
S
K
F
S
T
G
S
V
S
I
P
W
Q
N
E
M
I
E
T
E
C
F
K
E
L
N
V
F
G
P
N
G
T
L
P
P
D
L
N
-
R
N
H
P
P
--------------------------------
24
PsiBlast_CBE
84.85
66%
-106
- C1 -
4YHJ
1
?
B:
[25-527]
--------------------------
G
R
S
K
K
W
K
E
I
L
T
L
P
P
V
S
Q
C
S
E
L
R
H
S
I
E
K
D
Y
S
S
L
C
D
K
---
Q
P
I
G
R
R
L
F
R
Q
F
C
D
T
K
P
T
L
K
R
-
H
I
E
F
L
D
A
V
A
E
Y
E
-
V
A
D
D
E
D
R
S
D
C
G
L
S
I
L
D
R
F
F
-------
N
D
K
-
L
A
A
P
L
P
E
I
P
P
D
V
V
T
E
C
R
L
G
L
K
E
E
N
P
S
K
-----
K
A
F
E
E
C
T
R
V
A
H
N
Y
L
R
G
E
P
F
E
E
Y
Q
E
S
S
Y
F
S
Q
F
L
Q
W
K
W
L
E
R
Q
-
P
V
T
K
N
T
F
R
H
Y
R
V
L
G
K
G
G
F
G
E
V
C
A
C
Q
V
---
R
A
-----
T
G
----
K
M
Y
A
C
K
K
L
Q
K
K
R
I
-
K
K
-
R
K
---
G
E
A
M
A
L
N
E
K
R
I
L
-
E
K
-
V
-
Q
S
R
---
F
V
V
S
L
A
Y
A
Y
E
T
K
D
A
L
C
L
V
L
T
I
M
N
G
G
D
L
K
F
H
I
Y
N
L
G
--
N
--
P
G
-
F
D
E
Q
R
A
V
F
Y
A
A
E
L
C
C
G
L
E
D
L
Q
R
E
R
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
D
R
G
----
H
I
R
I
S
D
L
G
L
---
A
T
E
-
I
-
P
E
G
Q
-
R
-
V
R
G
R
V
----
G
T
V
G
Y
M
A
P
E
V
V
-
N
N
E
K
Y
T
F
S
P
D
W
W
G
L
G
C
L
I
Y
E
M
I
Q
G
H
S
P
-
F
K
K
Y
K
-
E
K
V
K
W
E
E
V
D
Q
R
I
K
N
----
D
T
E
E
Y
S
E
K
F
S
E
D
A
K
S
I
C
R
M
L
L
T
K
N
P
S
K
R
L
G
C
R
-
G
-
E
G
A
A
G
V
K
Q
H
P
V
F
K
D
I
N
F
R
R
L
E
A
N
M
L
E
P
P
F
C
P
D
P
H
A
V
Y
C
----------------
G
I
Y
L
D
T
A
D
E
D
F
Y
A
R
F
A
T
G
C
V
S
I
P
W
Q
N
E
M
I
E
S
G
C
F
K
D
I
N
K
--------------------------------------------------
7
PsiBlast_PDB
84.48
66%
-106
- C1 -
4YHJ
1
?
A:
[25-525]
--------------------------
G
R
S
K
K
W
K
E
I
L
T
L
P
P
V
S
Q
C
S
E
L
R
H
S
I
E
K
D
Y
S
S
L
C
D
K
---
Q
P
I
G
R
R
L
F
R
Q
F
C
D
T
K
P
T
L
K
R
-
H
I
E
F
L
D
A
V
A
E
Y
E
-
V
A
D
D
E
D
R
S
D
C
G
L
S
I
L
D
R
F
F
-------
N
D
K
-
L
A
A
P
L
P
E
I
P
P
D
V
V
T
E
C
R
L
G
L
K
E
E
N
P
S
K
-----
K
A
F
E
E
C
T
R
V
A
H
N
Y
L
R
G
E
P
F
E
E
Y
Q
E
S
S
Y
F
S
Q
F
L
Q
W
K
W
L
E
R
Q
-
P
V
T
K
N
T
F
R
H
Y
R
V
L
G
K
G
G
F
G
E
V
C
A
C
Q
V
---
R
A
-----
T
G
----
K
M
Y
A
C
K
K
L
Q
K
K
R
I
-
K
K
-
R
K
---
G
E
A
M
A
L
N
E
K
R
I
L
-
E
K
-
V
-
Q
S
R
---
F
V
V
S
L
A
Y
A
Y
E
T
K
D
A
L
C
L
V
L
T
I
M
N
G
G
D
L
K
F
H
I
Y
N
L
G
--
N
--
P
G
-
F
D
E
Q
R
A
V
F
Y
A
A
E
L
C
C
G
L
E
D
L
Q
R
E
R
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
D
R
G
----
H
I
R
I
S
D
L
G
L
---
A
T
E
-
I
-
P
E
G
Q
-
R
-
V
R
G
R
V
----
G
T
V
G
Y
M
A
P
E
V
V
-
N
N
E
K
Y
T
F
S
P
D
W
W
G
L
G
C
L
I
Y
E
M
I
Q
G
H
S
P
-
F
K
K
Y
K
-
E
K
V
K
W
E
E
V
D
Q
R
I
K
N
----
D
T
E
E
Y
S
E
K
F
S
E
D
A
K
S
I
C
R
M
L
L
T
K
N
P
S
K
R
L
G
C
R
-
G
-
E
G
A
A
G
V
K
Q
H
P
V
F
K
D
I
N
F
R
R
L
E
A
N
M
L
E
P
P
F
C
P
D
P
H
A
V
Y
C
K
D
V
L
D
I
E
Q
F
S
---
V
V
K
G
I
Y
L
D
T
A
D
E
D
F
Y
A
R
F
A
T
G
C
V
S
I
P
W
Q
N
E
M
I
E
S
G
C
F
K
D
I
----------------------------------------------------
30
PsiBlast_CBE
79.78
47%
-99
- C1 -
3C4W
1
RK_BOVIN
B:
[9-533]
-----
V
V
A
N
S
A
F
I
A
A
R
G
S
F
D
A
S
S
G
P
A
S
R
D
R
K
Y
L
A
R
L
K
L
P
P
L
S
K
C
E
A
L
R
E
S
L
D
L
G
F
E
G
M
C
L
E
---
Q
P
I
G
K
R
L
F
Q
Q
F
L
R
T
H
E
Q
H
G
P
-
A
L
Q
L
W
K
D
I
E
D
Y
D
-
T
A
D
D
A
L
R
P
Q
K
A
Q
A
L
R
A
A
Y
L
-------
E
P
Q
-
A
Q
L
F
C
S
F
L
D
A
E
T
V
A
----
R
A
-
R
A
G
--
D
-----
G
L
F
Q
P
L
L
R
A
V
L
A
H
L
G
Q
A
P
F
Q
E
F
L
D
S
L
Y
F
L
R
F
L
Q
W
K
W
L
E
A
Q
-
P
M
G
E
D
W
F
L
D
F
R
V
L
G
R
G
G
F
G
E
V
F
A
C
Q
M
---
K
A
-----
T
G
----
K
L
Y
A
C
K
K
L
N
K
K
R
L
-
K
K
-
R
K
---
G
Y
Q
G
A
M
V
E
K
K
I
L
-
A
K
-
V
-
H
S
R
---
F
I
V
S
L
A
Y
A
F
E
T
K
T
D
L
C
L
V
M
T
I
M
N
G
G
D
I
R
Y
H
I
Y
N
V
D
--
E
D
N
P
G
-
F
Q
E
P
R
A
I
F
Y
T
A
Q
I
V
S
G
L
E
H
L
H
Q
R
N
I
I
Y
R
D
L
K
P
E
N
V
L
L
D
D
D
G
----
N
V
R
I
S
D
L
G
L
---
A
V
E
-
L
-
K
A
G
Q
-
T
K
T
K
G
Y
A
----
G
T
P
G
F
M
A
P
E
L
L
-
L
G
E
E
Y
D
F
S
V
D
Y
F
A
L
G
V
T
L
Y
E
M
I
A
A
R
G
P
-
F
R
A
R
G
-
E
K
V
E
N
K
E
L
K
Q
R
V
L
E
----
Q
A
V
T
Y
P
D
K
F
S
P
A
S
K
D
F
C
E
A
L
L
Q
K
D
P
E
K
R
L
G
F
R
-
D
-
G
S
C
D
G
L
R
T
H
P
L
F
R
D
I
S
W
R
Q
L
E
A
G
M
L
T
P
P
F
V
P
D
S
R
T
V
Y
A
K
N
-----------
T
V
K
G
V
A
F
E
K
A
D
T
E
F
F
Q
E
F
A
S
G
T
C
P
I
P
W
Q
E
E
M
I
E
T
G
V
F
G
D
L
N
V
W
R
P
-----------------------------------------------
12
PsiBlast_PDB
78.73
47%
-104
- C1 -
3C4W
1
RK_BOVIN
A:
[31-533]
---------------------------
R
D
R
K
Y
L
A
R
L
K
L
P
P
L
S
K
C
E
A
L
R
E
S
L
D
L
G
F
E
G
M
C
L
E
---
Q
P
I
G
K
R
L
F
Q
Q
F
L
R
T
H
E
Q
H
G
P
-
A
L
Q
L
W
K
D
I
E
D
Y
D
-
T
A
D
D
A
L
R
P
Q
K
A
Q
A
L
R
A
A
Y
L
-------
E
P
Q
-
A
Q
L
F
C
S
F
L
D
A
E
T
V
A
----
R
A
-
R
A
G
A
G
D
-----
G
L
F
Q
P
L
L
R
A
V
L
A
H
L
G
Q
A
P
F
Q
E
F
L
D
S
L
Y
F
L
R
F
L
Q
W
K
W
L
E
A
Q
-
P
M
G
E
D
W
F
L
D
F
R
V
L
G
R
G
G
F
G
E
V
F
A
C
Q
M
---
K
A
-----
T
G
----
K
L
Y
A
C
K
K
L
N
K
K
R
L
-
K
K
-
R
K
---
G
Y
Q
G
A
M
V
E
K
K
I
L
-
A
K
-
V
-
H
S
R
---
F
I
V
S
L
A
Y
A
F
E
T
K
T
D
L
C
L
V
M
T
I
M
N
G
G
D
I
R
Y
H
I
Y
N
V
D
--
E
D
N
P
G
-
F
Q
E
P
R
A
I
F
Y
T
A
Q
I
V
S
G
L
E
H
L
H
Q
R
N
I
I
Y
R
D
L
K
P
E
N
V
L
L
D
D
D
G
----
N
V
R
I
S
D
L
G
L
---
A
V
E
-
L
-
K
A
G
Q
-
T
K
T
K
G
Y
A
----
G
T
P
G
F
M
A
P
E
L
L
-
L
G
E
E
Y
D
F
S
V
D
Y
F
A
L
G
V
T
L
Y
E
M
I
A
A
R
G
P
-
F
R
A
R
G
-
E
K
V
E
N
K
E
L
K
Q
R
V
L
E
----
Q
A
V
T
Y
P
D
K
F
S
P
A
S
K
D
F
C
E
A
L
L
Q
K
D
P
E
K
R
L
G
F
R
-
D
-
G
S
C
D
G
L
R
T
H
P
L
F
R
D
I
S
W
R
Q
L
E
A
G
M
L
T
P
P
F
V
P
D
---------
Q
D
V
G
A
F
S
---
T
V
K
G
V
A
F
E
K
A
D
T
E
F
F
Q
E
F
A
S
G
T
C
P
I
P
W
Q
E
E
M
I
E
T
G
V
F
G
D
L
N
V
W
R
P
-----------------------------------------------
14
PsiBlast_PDB
78.58
48%
-103
- C1 -
4L9I
2
RK_BOVIN
A:
[2-502]
---------------------------
R
D
R
K
Y
L
A
R
L
K
L
P
P
L
S
K
C
E
A
L
R
E
S
L
D
L
G
F
E
G
M
C
L
E
---
Q
P
I
G
K
R
L
F
Q
Q
F
L
R
T
H
E
Q
H
G
P
-
A
L
Q
L
W
K
D
I
E
D
Y
D
-
T
A
D
D
A
L
R
P
Q
K
A
Q
A
L
R
A
A
Y
L
-------
E
P
Q
-
A
Q
L
F
C
S
F
L
D
A
E
T
V
A
----
R
A
-
R
A
G
A
G
D
-----
G
L
F
Q
P
L
L
R
A
V
L
A
H
L
G
Q
A
P
F
Q
E
F
L
D
S
L
Y
F
L
R
F
L
Q
W
K
W
L
E
A
Q
-
P
M
G
E
D
W
F
L
D
F
R
V
L
G
R
G
G
F
G
E
V
F
A
C
Q
M
---
K
A
-----
T
G
----
K
L
Y
A
C
K
K
L
N
K
K
R
L
-
K
K
-
R
K
---
G
Y
Q
G
A
M
V
E
K
K
I
L
-
A
K
-
V
-
H
S
R
---
F
I
V
S
L
A
Y
A
F
E
T
K
T
D
L
C
L
V
M
T
I
M
N
G
G
D
I
R
Y
H
I
Y
N
V
D
--
E
DN
P
G
-
F
Q
E
P
R
A
I
F
Y
T
A
Q
I
V
S
G
L
E
H
L
H
Q
R
N
I
I
Y
R
D
L
K
P
E
N
V
L
L
D
D
D
G
----
N
V
R
I
S
D
L
G
L
---
A
V
E
-
L
-
K
A
G
Q
-
T
K
T
K
G
Y
A
----
G
T
P
G
F
M
A
P
E
L
L
-
L
G
E
E
Y
D
F
S
V
D
Y
F
A
L
G
V
T
L
Y
E
M
I
A
A
R
G
P
-
F
R
A
R
G
-
E
K
V
E
N
K
E
L
K
Q
R
V
L
E
----
Q
A
V
T
Y
P
D
K
F
S
P
A
S
K
D
F
C
E
A
L
L
Q
K
D
P
E
K
R
L
G
F
R
-
D
-
G
S
C
D
G
L
R
T
H
P
L
F
R
D
I
S
W
R
Q
L
E
A
G
M
L
T
P
P
F
V
P
D
S
R
T
V
Y
A
K
N
I
Q
D
V
G
A
F
S
---
T
V
K
G
V
A
F
E
K
A
D
T
E
F
F
Q
E
F
A
S
G
T
C
P
I
P
W
Q
E
E
M
I
E
T
G
V
F
G
D
L
N
V
W
R
P
-----------------------------------------------
8
PsiBlast_PDB
78.02
47%
-101
- C1 -
3C4X
1
RK_BOVIN
A:
[30-533]
--------------------------
S
R
D
R
K
Y
L
A
R
L
K
L
P
P
L
S
K
C
E
A
L
R
E
S
L
D
L
G
F
E
G
M
C
L
E
---
Q
P
I
G
K
R
L
F
Q
Q
F
L
R
T
H
E
Q
H
G
P
-
A
L
Q
L
W
K
D
I
E
D
Y
D
-
T
A
D
D
A
L
R
P
Q
K
A
Q
A
L
R
A
A
Y
L
-------
E
P
Q
-
A
Q
L
F
C
S
F
L
D
A
E
T
V
A
----
R
A
-
R
A
G
A
G
D
-----
G
L
F
Q
P
L
L
R
A
V
L
A
H
L
G
Q
A
P
F
Q
E
F
L
D
S
L
Y
F
L
R
F
L
Q
W
K
W
L
E
A
Q
-
P
M
G
E
D
W
F
L
D
F
R
V
L
G
R
G
G
F
G
E
V
F
A
C
Q
M
---
K
A
-----
T
G
----
K
L
Y
A
C
K
K
L
N
K
K
R
L
-
K
K
-
R
K
---
G
Y
Q
G
A
M
V
E
K
K
I
L
-
A
K
-
V
-
H
S
R
---
F
I
V
S
L
A
Y
A
F
E
T
K
T
D
L
C
L
V
M
T
I
M
N
G
G
D
I
R
Y
H
I
Y
N
V
D
--
E
D
N
P
G
-
F
Q
E
P
R
A
I
F
Y
T
A
Q
I
V
S
G
L
E
H
L
H
Q
R
N
I
I
Y
R
D
L
K
P
E
N
V
L
L
D
D
D
G
----
N
V
R
I
S
D
L
G
L
---
A
V
E
-
L
-
K
A
G
Q
-
T
K
T
K
G
Y
A
----
G
T
P
G
F
M
A
P
E
L
L
-
L
G
E
E
Y
D
F
S
V
D
Y
F
A
L
G
V
T
L
Y
E
M
I
A
A
R
G
P
-
F
R
A
R
G
-
E
K
V
E
N
K
E
L
K
Q
R
V
L
E
----
Q
A
V
T
Y
P
D
K
F
S
P
A
S
K
D
F
C
E
A
L
L
Q
K
D
P
E
K
R
L
G
F
R
-
D
-
G
S
C
D
G
L
R
T
H
P
L
F
R
D
I
S
W
R
Q
L
E
A
G
M
L
T
P
P
F
V
P
D
--------
I
Q
D
V
G
A
F
S
---
T
V
K
G
V
A
F
E
K
A
D
T
E
F
F
Q
E
F
A
S
G
T
C
P
I
P
W
Q
E
E
M
I
E
T
G
V
F
G
D
L
N
V
W
R
P
-----------------------------------------------
25
PsiBlast_CBE
77.95
47%
-103
- C1 -
3C50
1
RK_BOVIN
B:
[30-533]
--------------------------
S
R
D
R
K
Y
L
A
R
L
K
L
P
P
L
S
K
C
E
A
L
R
E
S
L
D
L
G
F
E
G
M
C
L
E
---
Q
P
I
G
K
R
L
F
Q
Q
F
L
R
T
H
E
Q
H
G
P
-
A
L
Q
L
W
K
D
I
E
D
Y
D
-
T
A
D
D
A
L
R
P
Q
K
A
Q
A
L
R
A
A
Y
L
-------
E
P
Q
-
A
Q
L
F
C
S
F
L
D
A
E
T
V
A
----
R
A
-
R
A
G
A
G
D
-----
G
L
F
Q
P
L
L
R
A
V
L
A
H
L
G
Q
A
P
F
Q
E
F
L
D
S
L
Y
F
L
R
F
L
Q
W
K
W
L
E
A
Q
-
P
M
G
E
D
W
F
L
D
F
R
V
L
G
R
G
G
F
G
E
V
F
A
C
Q
M
---
K
A
-----
T
G
----
K
L
Y
A
C
K
K
L
N
K
K
R
L
-
K
K
-
R
K
---
G
Y
Q
G
A
M
V
E
K
K
I
L
-
A
K
-
V
-
H
S
R
---
F
I
V
S
L
A
Y
A
F
E
T
K
T
D
L
C
L
V
M
T
I
M
N
G
G
D
I
R
Y
H
I
Y
N
V
D
--
E
DN
P
G
-
F
Q
E
P
R
A
I
F
Y
T
A
Q
I
V
S
G
L
E
H
L
H
Q
R
N
I
I
Y
R
D
L
K
P
E
N
V
L
L
D
D
D
G
----
N
V
R
I
S
D
L
G
L
---
A
V
E
-
L
-
K
A
G
Q
-
T
K
T
K
G
Y
A
----
G
T
P
G
F
M
A
P
E
L
L
-
L
G
E
E
Y
D
F
S
V
D
Y
F
A
L
G
V
T
L
Y
E
M
I
A
A
R
G
P
-
F
R
A
R
G
-
E
K
V
E
N
K
E
L
K
Q
R
V
L
E
----
Q
A
V
T
Y
P
D
K
F
S
P
A
S
K
D
F
C
E
A
L
L
Q
K
D
P
E
K
R
L
G
F
R
-
D
-
G
S
C
D
G
L
R
T
H
P
L
F
R
D
I
S
W
R
Q
L
E
A
G
M
L
T
P
P
F
V
P
D
S
R
T
V
Y
A
--------
F
S
---
T
V
K
G
V
A
F
E
K
A
D
T
E
F
F
Q
E
F
A
S
G
T
C
P
I
P
W
Q
E
E
M
I
E
T
G
V
F
G
D
L
N
V
W
R
P
-----------------------------------------------
94
Fugue
77.90
48%
-104
- C1 -
3C4Z
1
RK_BOVIN
A:
[31-533]
---------------------------
R
D
R
K
Y
L
A
R
L
K
L
P
P
L
S
K
C
E
A
L
R
E
S
L
D
L
G
F
E
G
M
C
L
E
---
Q
P
I
G
K
R
L
F
Q
Q
F
L
R
T
H
E
Q
H
G
P
-
A
L
Q
L
W
K
D
I
E
D
Y
D
-
T
A
D
D
A
L
R
P
Q
K
A
Q
A
L
R
A
A
Y
L
-------
E
P
Q
-
A
Q
L
F
C
S
F
L
D
A
E
T
V
A
R
A
R
A
--------
G
-----
G
L
F
Q
P
L
L
R
A
V
L
A
H
L
G
Q
A
P
F
Q
E
F
L
D
S
L
Y
F
L
R
F
L
Q
W
K
W
L
E
A
Q
-
P
M
G
E
D
W
F
L
D
F
R
V
L
G
R
G
G
F
G
E
V
F
A
C
Q
M
---
K
A
-----
T
G
----
K
L
Y
A
C
K
K
L
N
K
K
R
L
-
K
K
-
R
K
---
G
Y
Q
G
A
M
V
E
K
K
I
L
-
A
K
-
V
-
H
S
R
---
F
I
V
S
L
A
Y
A
F
E
T
K
T
D
L
C
L
V
M
T
I
M
N
G
G
D
I
R
Y
H
I
Y
N
V
D
--
E
D
N
P
G
-
F
Q
E
P
R
A
I
F
Y
T
A
Q
I
V
S
G
L
E
H
L
H
Q
R
N
I
I
Y
R
D
L
K
P
E
N
V
L
L
D
D
D
G
----
N
V
R
I
S
D
L
G
L
---
A
V
E
-
L
-
K
A
G
Q
T
K
-
T
K
G
Y
A
----
G
T
P
G
F
M
A
P
E
L
L
-
L
G
E
E
Y
D
F
S
V
D
Y
F
A
L
G
V
T
L
Y
E
M
I
A
A
R
G
P
-
F
R
A
R
G
-
E
K
V
E
N
K
E
L
K
Q
R
V
L
E
----
Q
A
V
T
Y
P
D
K
F
S
P
A
S
K
D
F
C
E
A
L
L
Q
K
D
P
E
K
R
L
G
F
R
-
D
-
G
S
C
D
G
L
R
T
H
P
L
F
R
D
I
S
W
R
Q
L
E
A
G
M
L
T
P
P
F
V
P
D
S
R
T
V
Y
A
K
N
-------
G
---
A
F
S
G
V
A
F
E
K
A
D
T
E
F
F
Q
E
F
A
S
G
T
C
P
I
P
W
Q
E
E
M
I
E
T
G
V
F
G
D
L
N
V
W
R
P
-----------------------------------------------
26
PsiBlast_CBE
77.86
47%
-106
- C1 -
3C4X
1
RK_BOVIN
B:
[31-533]
---------------------------
R
D
R
K
Y
L
A
R
L
K
L
P
P
L
S
K
C
E
A
L
R
E
S
L
D
L
G
F
E
G
M
C
L
E
---
Q
P
I
G
K
R
L
F
Q
Q
F
L
R
T
H
E
Q
H
G
P
-
A
L
Q
L
W
K
D
I
E
D
Y
D
-
T
A
D
D
A
L
R
P
Q
K
A
Q
A
L
R
A
A
Y
L
-------
E
P
Q
-
A
Q
L
F
C
S
F
L
D
A
E
T
V
A
----
R
A
--------------
F
Q
P
L
L
R
A
V
L
A
H
L
G
Q
A
P
F
Q
E
F
L
D
S
L
Y
F
L
R
F
L
Q
W
K
W
L
E
A
Q
-
P
M
G
E
D
W
F
L
D
F
R
V
L
G
R
G
G
F
G
E
V
F
A
C
Q
M
---
K
A
-----
T
G
----
K
L
Y
A
C
K
K
L
N
K
K
R
L
-
K
K
-
R
K
---
G
Y
Q
G
A
M
V
E
K
K
I
L
-
A
K
-
V
-
H
S
R
---
F
I
V
S
L
A
Y
A
F
E
T
K
T
D
L
C
L
V
M
T
I
M
N
G
G
D
I
R
Y
H
I
Y
N
V
D
--
E
DN
P
G
-
F
Q
E
P
R
A
I
F
Y
T
A
Q
I
V
S
G
L
E
H
L
H
Q
R
N
I
I
Y
R
D
L
K
P
E
N
V
L
L
D
D
D
G
----
N
V
R
I
S
D
L
G
L
---
A
V
E
-
L
-
K
A
G
Q
-
T
K
T
K
G
Y
A
----
G
T
P
G
F
M
A
P
E
L
L
-
L
G
E
E
Y
D
F
S
V
D
Y
F
A
L
G
V
T
L
Y
E
M
I
A
A
R
G
P
-
F
R
A
R
G
-
E
K
V
E
N
K
E
L
K
Q
R
V
L
E
----
Q
A
V
T
Y
P
D
K
F
S
P
A
S
K
D
F
C
E
A
L
L
Q
K
D
P
E
K
R
L
G
F
R
-
D
-
G
S
C
D
G
L
R
T
H
P
L
F
R
D
I
S
W
R
Q
L
E
A
G
M
L
T
P
P
F
V
P
D
S
R
T
-----------------------
E
K
A
D
T
E
F
F
Q
E
F
A
S
G
T
C
P
I
P
W
Q
E
E
M
I
E
T
G
V
F
G
D
L
N
V
W
R
P
-----------------------------------------------
10
PsiBlast_PDB
77.82
47%
-104
- C1 -
3C4Z
1
RK_BOVIN
A:
[31-533]
---------------------------
R
D
R
K
Y
L
A
R
L
K
L
P
P
L
S
K
C
E
A
L
R
E
S
L
D
L
G
F
E
G
M
C
L
E
---
Q
P
I
G
K
R
L
F
Q
Q
F
L
R
T
H
E
Q
H
G
P
-
A
L
Q
L
W
K
D
I
E
D
Y
D
-
T
A
D
D
A
L
R
P
Q
K
A
Q
A
L
R
A
A
Y
L
-------
E
P
Q
-
A
Q
L
F
C
S
F
L
D
A
E
T
V
A
----
R
A
-
R
A
G
--------
G
L
F
Q
P
L
L
R
A
V
L
A
H
L
G
Q
A
P
F
Q
E
F
L
D
S
L
Y
F
L
R
F
L
Q
W
K
W
L
E
A
Q
-
P
M
G
E
D
W
F
L
D
F
R
V
L
G
R
G
G
F
G
E
V
F
A
C
Q
M
---
K
A
-----
T
G
----
K
L
Y
A
C
K
K
L
N
K
K
R
L
-
K
K
-
R
K
---
G
Y
Q
G
A
M
V
E
K
K
I
L
-
A
K
-
V
-
H
S
R
---
F
I
V
S
L
A
Y
A
F
E
T
K
T
D
L
C
L
V
M
T
I
M
N
G
G
D
I
R
Y
H
I
Y
N
V
D
--
E
D
N
P
G
-
F
Q
E
P
R
A
I
F
Y
T
A
Q
I
V
S
G
L
E
H
L
H
Q
R
N
I
I
Y
R
D
L
K
P
E
N
V
L
L
D
D
D
G
----
N
V
R
I
S
D
L
G
L
---
A
V
E
-
L
-
K
A
G
Q
-
T
K
T
K
G
Y
A
----
G
T
P
G
F
M
A
P
E
L
L
-
L
G
E
E
Y
D
F
S
V
D
Y
F
A
L
G
V
T
L
Y
E
M
I
A
A
R
G
P
-
F
R
A
R
G
-
E
K
V
E
N
K
E
L
K
Q
R
V
L
E
----
Q
A
V
T
Y
P
D
K
F
S
P
A
S
K
D
F
C
E
A
L
L
Q
K
D
P
E
K
R
L
G
F
R
-
D
-
G
S
C
D
G
L
R
T
H
P
L
F
R
D
I
S
W
R
Q
L
E
A
G
M
L
T
P
P
F
V
P
D
S
R
T
V
Y
A
K
N
----
G
A
F
S
------
G
V
A
F
E
K
A
D
T
E
F
F
Q
E
F
A
S
G
T
C
P
I
P
W
Q
E
E
M
I
E
T
G
V
F
G
D
L
N
V
W
R
P
-----------------------------------------------
103
HHSearch
77.51
48%
-105
- C1 -
3C4Z
1
RK_BOVIN
A:
[31-533]
---------------------------
R
D
R
K
Y
L
A
R
L
K
L
P
P
L
S
K
C
E
A
L
R
E
S
L
D
L
G
F
E
G
M
C
L
E
---
Q
P
I
G
K
R
L
F
Q
Q
F
L
R
T
H
E
Q
H
G
P
-
A
L
Q
L
W
K
D
I
E
D
Y
D
-
T
A
D
D
A
L
R
P
Q
K
A
Q
A
L
R
A
A
Y
L
-------
E
P
Q
-
A
Q
L
F
C
S
F
L
D
A
E
T
V
A
R
A
R
A
-----
G
--------
G
L
F
Q
P
L
L
R
A
V
L
A
H
L
G
Q
A
P
F
Q
E
F
L
D
S
L
Y
F
L
R
F
L
Q
W
K
W
L
E
A
Q
-
P
M
G
E
D
W
F
L
D
F
R
V
L
G
R
G
G
F
G
E
V
F
A
C
Q
M
---
K
A
-----
T
G
----
K
L
Y
A
C
K
K
L
N
K
K
R
L
-
K
K
-
R
K
---
G
Y
Q
G
A
M
V
E
K
K
I
L
-
A
K
-
V
-
H
S
R
---
F
I
V
S
L
A
Y
A
F
E
T
K
T
D
L
C
L
V
M
T
I
M
N
G
G
D
I
R
Y
H
I
Y
N
V
D
ED
N
--
P
G
-
F
Q
E
P
R
A
I
F
Y
T
A
Q
I
V
S
G
L
E
H
L
H
Q
R
N
I
I
Y
R
D
L
K
P
E
N
V
L
L
D
D
D
G
----
N
V
R
I
S
D
L
G
L
---
A
V
E
-
L
K
A
G
Q
T
-
K
-
T
K
G
Y
A
----
G
T
P
G
F
M
A
P
E
L
L
-
L
G
E
E
Y
D
F
S
V
D
Y
F
A
L
G
V
T
L
Y
E
M
I
A
A
R
G
P
-
F
R
A
R
G
-
E
K
V
E
N
K
E
L
K
Q
R
V
L
E
----
Q
A
V
T
Y
P
D
K
F
S
P
A
S
K
D
F
C
E
A
L
L
Q
K
D
P
E
K
R
L
G
F
R
-
D
-
G
S
C
D
G
L
R
T
H
P
L
F
R
D
I
S
W
R
Q
L
E
A
G
M
L
T
P
P
F
V
P
D
S
R
T
V
Y
A
K
N
----
G
A
F
S
------
G
V
A
F
E
K
A
D
T
E
F
F
Q
E
F
A
S
G
T
C
P
I
P
W
Q
E
E
M
I
E
T
G
V
F
G
D
L
N
V
W
R
P
-----------------------------------------------
11
PsiBlast_PDB
74.99
47%
-101
- C1 -
3C51
1
RK_BOVIN
A:
[31-533]
---------------------------
R
D
R
K
Y
L
A
R
L
K
L
P
P
L
S
K
C
E
A
L
R
E
S
L
D
L
G
F
E
G
M
C
L
E
---
Q
P
I
G
K
R
L
F
Q
Q
F
L
R
T
H
E
Q
H
G
P
-
A
L
Q
L
W
K
D
I
E
D
Y
D
-
T
A
D
D
A
L
R
P
Q
K
A
Q
A
L
R
A
A
Y
L
-------
E
P
Q
-
A
Q
L
F
C
S
F
L
D
A
E
T
V
A
----
R
A
-
R
A
G
--------
G
L
F
Q
P
L
L
R
A
V
L
A
H
L
G
Q
A
P
F
Q
E
F
L
D
S
L
Y
F
L
R
F
L
Q
W
K
W
L
E
A
Q
-
P
M
G
E
D
W
F
L
D
F
R
V
L
G
R
G
G
F
G
E
V
F
A
C
Q
M
---
K
A
-----
T
G
----
K
L
Y
A
C
K
K
L
N
K
K
R
L
-
K
K
-
R
K
---
G
Y
Q
G
A
M
V
E
K
K
I
L
-
A
K
-
V
-
H
S
R
---
F
I
V
S
L
A
Y
A
F
E
T
K
T
D
L
C
L
V
M
T
I
M
N
G
G
D
I
R
Y
H
I
Y
N
V
D
--
E
DN
P
G
-
F
Q
E
P
R
A
I
F
Y
T
A
Q
I
V
S
G
L
E
H
L
H
Q
R
N
I
I
Y
R
D
L
K
P
E
N
V
L
L
D
D
D
G
----
N
V
R
I
S
D
L
G
L
---
A
V
E
-
L
-
K
A
G
Q
-
T
K
T
K
G
Y
A
----
G
T
P
G
F
M
A
P
E
L
L
-
L
G
E
E
Y
D
F
S
V
D
Y
F
A
L
G
V
T
L
Y
E
M
I
A
A
R
G
P
-
F
R
A
R
G
-
E
K
V
E
N
K
E
L
K
Q
R
V
L
E
----
Q
A
V
T
Y
P
D
K
F
S
P
A
S
K
D
F
C
E
A
L
L
Q
K
D
P
E
K
R
L
G
F
R
-
D
-
G
S
C
D
G
L
R
T
H
P
L
F
R
D
I
S
W
R
Q
L
E
A
G
M
L
T
P
P
F
V
P
D
S
R
-------------
S
---
T
V
K
G
V
A
F
E
K
A
D
T
E
F
F
Q
E
F
A
S
G
T
C
P
I
P
W
Q
E
E
M
I
E
T
G
V
F
G
D
L
N
V
W
R
P
-----------------------------------------------
34
PsiBlast_CBE
66.52
38%
-92
- C1 -
3PVW
1
ARBK1_BOVIN
A:
[29-531]
-----------------------------
S
K
-
K
I
L
L
P
E
P
S
I
R
S
V
--
M
Q
K
Y
L
E
D
R
G
E
V
T
F
E
K
I
F
S
Q
K
L
G
Y
L
L
F
R
D
F
C
L
K
H
L
E
E
A
K
P
L
V
E
F
Y
E
E
I
K
K
Y
E
K
L
E
T
E
E
E
R
L
V
C
S
R
E
I
F
D
T
Y
I
M
K
E
L
L
A
C
S
H
P
F
S
K
S
A
I
E
H
V
Q
G
H
L
V
K
-------
K
Q
V
P
-
P
-----
D
L
F
Q
P
Y
I
E
E
I
C
Q
N
L
R
G
D
V
F
Q
K
F
I
E
S
D
K
F
T
R
F
C
Q
W
K
N
V
E
L
N
I
H
L
T
M
N
D
F
S
V
H
R
I
I
G
R
G
G
F
G
E
V
Y
G
C
R
K
---
A
D
-----
T
G
----
K
M
Y
A
M
K
C
L
D
K
K
R
I
-
K
M
-
K
Q
---
G
E
T
L
A
L
N
E
R
I
M
L
-
S
L
-
V
-
S
T
G
DCP
F
I
V
C
M
S
Y
A
F
H
T
P
D
K
L
S
F
I
L
D
L
M
N
G
G
D
L
H
---
Y
H
L
S
--
Q
--
H
G
V
F
S
E
A
D
M
R
F
Y
A
A
E
I
I
L
G
L
E
H
M
H
N
R
F
V
V
Y
R
D
L
K
P
A
N
I
L
L
D
E
H
G
----
H
V
R
I
S
D
L
G
L
---
A
C
D
-
F
-
S
K
K
K
-
P
--
H
A
S
V
----
G
T
H
G
Y
M
A
P
E
V
L
Q
K
G
V
A
Y
D
S
S
A
D
W
F
S
L
G
C
M
L
F
K
L
L
R
G
H
S
P
-
F
R
Q
H
K
-
T
K
D
K
H
-
E
I
D
R
M
T
L
T
----
M
A
V
E
L
P
D
S
F
S
P
E
L
R
S
L
L
E
G
L
L
Q
R
D
V
N
R
R
L
G
C
L
-
G
-
R
G
A
Q
E
V
K
E
S
P
F
F
R
S
L
D
W
Q
M
V
F
L
Q
K
Y
P
P
P
L
I
P
P
R
G
----------------------
K
L
L
D
S
D
Q
E
L
Y
R
N
F
P
L
-
T
I
S
E
R
W
Q
Q
E
V
A
E
T
-
V
F
D
T
I
N
A
E
T
D
R
L
E
A
R
K
K
T
K
N
K
Q
L
G
H
E
E
D
Y
A
L
G
K
D
C
I
M
H
G
Y
M
S
K
M
G
W
Q
R
R
Y
F
Y
L
F
P
N
R
35
PsiBlast_CBE
65.41
38%
-97
- C1 -
3PVU
1
ARBK1_BOVIN
A:
[30-531]
------------------------------
K
-
K
I
L
L
P
E
P
S
I
R
S
V
--
M
Q
K
Y
L
E
D
R
G
E
V
T
F
E
K
I
F
S
Q
K
L
G
Y
L
L
F
R
D
F
C
L
K
H
L
E
E
A
K
P
L
V
E
F
Y
E
E
I
K
K
Y
E
K
L
E
T
E
E
E
R
L
V
C
S
R
E
I
F
D
T
Y
I
M
K
E
L
L
A
C
S
H
P
F
S
K
S
A
I
E
H
V
Q
G
H
L
V
K
-------
K
Q
V
P
-
P
-----
D
L
F
Q
P
Y
I
E
E
I
C
Q
N
L
R
G
D
V
F
Q
K
F
I
E
S
D
K
F
T
R
F
C
Q
W
K
N
V
E
L
N
I
H
L
T
M
N
D
F
S
V
H
R
I
I
G
R
G
G
F
G
E
V
Y
G
C
R
K
---
A
D
-----
T
G
----
K
M
Y
A
M
K
C
L
D
K
K
R
I
-
K
M
-
K
Q
---
G
E
T
L
A
L
N
E
R
I
M
L
-
S
L
-
V
-
S
T
G
DCP
F
I
V
C
M
S
Y
A
F
H
T
P
D
K
L
S
F
I
L
D
L
M
N
G
G
D
L
H
---
Y
H
L
S
--
Q
--
H
G
V
F
S
E
A
D
M
R
F
Y
A
A
E
I
I
L
G
L
E
H
M
H
N
R
F
V
V
Y
R
D
L
K
P
A
N
I
L
L
D
E
H
G
----
H
V
R
I
S
D
L
G
L
---
A
C
D
-
F
-
S
K
K
K
-
P
--
H
A
S
V
----
G
T
H
G
Y
M
A
P
E
V
L
Q
K
G
V
A
Y
D
S
S
A
D
W
F
S
L
G
C
M
L
F
K
L
L
R
G
H
S
P
-
F
R
Q
H
K
-
T
K
D
K
H
-
E
I
D
R
M
T
L
T
----
M
A
V
E
L
P
D
S
F
S
P
E
L
R
S
L
L
E
G
L
L
Q
R
D
V
N
R
R
L
G
C
L
-
G
-
R
G
A
Q
E
V
K
E
S
P
F
F
R
S
L
D
W
Q
M
V
F
L
Q
K
Y
P
P
P
L
I
P
P
R
G
-------------------------
D
S
D
Q
E
L
Y
R
N
F
P
L
-
T
I
S
E
R
W
Q
Q
E
V
A
E
T
-
V
F
D
T
I
N
A
E
T
D
R
L
E
A
R
K
K
T
K
N
K
Q
L
G
H
E
E
D
Y
A
L
G
K
D
C
I
M
H
G
Y
M
S
K
M
G
W
Q
R
R
Y
F
Y
L
F
P
N
R
39
PsiBlast_CBE
63.65
38%
-89
- C1 -
3KRW
1
ARBK1_HUMAN
A:
[29-530]
------------------------------
K
-
K
I
L
L
P
E
P
S
I
R
S
V
--
M
Q
K
Y
L
E
D
R
G
E
V
T
F
E
K
I
F
S
Q
K
L
G
Y
L
L
F
R
D
F
C
L
N
H
L
E
E
A
R
P
L
V
E
F
Y
E
E
I
K
K
Y
E
K
L
E
T
E
E
E
R
V
A
R
S
R
E
I
---
F
D
-------
S
Y
I
-
M
K
E
L
L
A
---
H
P
F
S
K
S
A
T
E
H
V
-
Q
G
H
L
G
K
KQVPP
D
L
F
Q
P
Y
I
E
E
I
C
Q
N
L
R
G
D
V
F
Q
K
F
I
E
S
D
K
F
T
R
F
C
Q
W
K
N
V
E
L
N
I
H
L
T
M
N
D
F
S
V
H
R
I
I
G
R
G
G
F
G
E
V
Y
G
C
R
K
---
A
D
-----
T
G
----
K
M
Y
A
M
K
C
L
D
K
K
R
I
-
K
M
-
K
Q
---
G
E
T
L
A
L
N
E
R
I
M
L
-
S
L
-
V
-
S
T
G
DCP
F
I
V
C
M
S
Y
A
F
H
T
P
D
K
L
S
F
I
L
D
L
M
N
G
G
D
L
H
---
Y
H
L
S
--
Q
--
H
G
V
F
S
E
A
D
M
R
F
Y
A
A
E
I
I
L
G
L
E
H
M
H
N
R
F
V
V
Y
R
D
L
K
P
A
N
I
L
L
D
E
H
G
----
H
V
R
I
S
D
L
G
L
---
A
C
D
-
F
-
S
K
K
K
-
P
--
H
A
S
V
----
G
T
H
G
Y
M
A
P
E
V
L
Q
K
G
V
A
Y
D
S
S
A
D
W
F
S
L
G
C
M
L
F
K
L
L
R
G
H
S
P
-
F
R
Q
H
K
-
T
K
D
K
H
-
E
I
D
R
M
T
L
T
----
M
A
V
E
L
P
D
S
F
S
P
E
L
R
S
L
L
E
G
L
L
Q
R
D
V
N
R
R
L
G
C
L
-
G
-
R
G
A
Q
E
V
K
E
S
P
F
F
R
S
L
D
W
Q
M
V
F
L
Q
K
Y
P
P
P
L
I
P
P
R
---------------EE-
D
T
K
G
I
K
L
L
D
S
D
Q
E
L
Y
R
N
F
P
L
-
T
I
S
E
R
W
Q
Q
E
V
A
E
T
-
V
F
D
T
I
N
A
E
T
D
R
L
E
A
R
K
K
A
K
N
K
Q
L
G
H
E
E
D
Y
A
L
G
K
D
C
I
M
H
G
Y
M
S
K
M
W
Q
R
R
Y
F
Y
L
F
P
N
R
L
36
PsiBlast_CBE
63.53
38%
-92
- C1 -
4PNK
1
ARBK1_HUMAN
A:
[30-531]
------------------------------
K
-
K
I
L
L
P
E
P
S
I
R
S
V
--
M
Q
K
Y
L
E
D
R
G
E
V
T
F
E
K
I
F
S
Q
K
L
G
Y
L
L
F
R
D
F
C
L
N
H
L
E
E
A
R
P
L
V
E
F
Y
E
E
I
K
K
Y
E
K
L
E
T
E
E
E
R
V
A
R
S
R
E
I
---
F
D
-------
S
Y
I
-
M
K
E
L
L
A
-
C
S
H
P
F
S
K
S
A
T
E
H
V
-
Q
G
H
L
G
K
KQVPP
D
L
F
Q
P
Y
I
E
E
I
C
Q
N
L
R
G
D
V
F
Q
K
F
I
E
S
D
K
F
T
R
F
C
Q
W
K
N
V
E
L
N
I
H
L
T
M
N
D
F
S
V
H
R
I
I
G
R
G
G
F
G
E
V
Y
G
C
R
K
---
A
D
-----
T
G
----
K
M
Y
A
M
K
C
L
D
K
K
R
I
-
K
M
-
K
Q
---
G
E
T
L
A
L
N
E
R
I
M
L
-
S
L
-
V
-
S
T
G
DCP
F
I
V
C
M
S
Y
A
F
H
T
P
D
K
L
S
F
I
L
D
L
M
N
G
G
D
L
H
---
Y
H
L
S
--
Q
--
H
G
V
F
S
E
A
D
M
R
F
Y
A
A
E
I
I
L
G
L
E
H
M
H
N
R
F
V
V
Y
R
D
L
K
P
A
N
I
L
L
D
E
H
G
----
H
V
R
I
S
D
L
G
L
---
A
C
D
-
F
-
S
K
K
K
-
P
--
H
A
S
V
----
G
T
H
G
Y
M
A
P
E
V
L
Q
K
G
V
A
Y
D
S
S
A
D
W
F
S
L
G
C
M
L
F
K
L
L
R
G
H
S
P
-
F
R
Q
H
K
-
T
K
D
K
H
-
E
I
D
R
M
T
L
T
----
M
A
V
E
L
P
D
S
F
S
P
E
L
R
S
L
L
E
G
L
L
Q
R
D
V
N
R
R
L
G
C
L
-
G
-
R
G
A
Q
E
V
K
E
S
P
F
F
R
S
L
D
W
Q
M
V
F
L
Q
K
Y
P
P
P
L
I
P
P
R
-
E
V
N
A
--------------
T
K
G
I
K
L
L
D
S
D
Q
E
L
Y
R
N
F
P
L
-
T
I
S
E
R
W
Q
Q
E
V
A
E
T
-
V
F
D
T
I
N
A
E
T
D
R
L
E
A
R
K
K
A
K
N
K
Q
L
G
H
E
E
D
Y
A
L
G
K
D
C
I
M
H
G
Y
M
S
K
M
G
N
P
F
L
T
Q
W
Q
R
R
Y
F
38
PsiBlast_CBE
62.94
38%
-88
- C1 -
3KRX
1
ARBK1_HUMAN
A:
[29-530]
------------------------------
K
-
K
I
L
L
P
E
P
S
I
R
S
V
--
M
Q
K
Y
L
E
D
R
G
E
V
T
F
E
K
I
F
S
Q
K
L
G
Y
L
L
F
R
D
F
C
L
N
H
L
E
E
A
R
P
L
V
E
F
Y
E
E
I
K
K
Y
E
K
L
E
T
E
E
E
R
V
A
R
S
R
E
I
---
F
D
-------
S
Y
I
-
M
K
E
L
L
A
---
H
P
F
S
K
S
A
T
E
H
V
-
Q
G
H
L
G
K
KQVPP
D
L
F
Q
P
Y
I
E
E
I
C
Q
N
L
R
G
D
V
F
Q
K
F
I
E
S
D
K
F
T
R
F
C
Q
W
K
N
V
E
L
N
I
H
L
T
M
N
D
F
S
V
H
R
I
I
G
R
G
G
F
G
E
V
Y
G
C
R
K
---
A
D
-----
T
G
----
K
M
Y
A
M
K
C
L
D
K
K
R
I
-
K
M
-
K
Q
---
G
E
T
L
A
L
N
E
R
I
M
L
-
S
L
-
V
-
S
T
G
DCP
F
I
V
C
M
S
Y
A
F
H
T
P
D
K
L
S
F
I
L
D
L
M
N
G
G
D
L
H
---
Y
H
L
S
--
Q
--
H
G
V
F
S
E
A
D
M
R
F
Y
A
A
E
I
I
L
G
L
E
H
M
H
N
R
F
V
V
Y
R
D
L
K
P
A
N
I
L
L
D
E
H
G
----
H
V
R
I
S
D
L
G
L
---
A
C
D
-
F
-
S
K
K
K
-
P
--
H
A
S
V
----
G
T
H
G
Y
M
A
P
E
V
L
Q
K
G
V
A
Y
D
S
S
A
D
W
F
S
L
G
C
M
L
F
K
L
L
R
G
H
S
P
-
F
R
Q
H
K
-
T
K
D
K
H
-
E
I
D
R
M
T
L
T
----
M
A
V
E
L
P
D
S
F
S
P
E
L
R
S
L
L
E
G
L
L
Q
R
D
V
N
R
R
L
G
C
L
-
G
-
R
G
A
Q
E
V
K
E
S
P
F
F
R
S
L
D
W
Q
M
V
F
L
Q
K
Y
P
P
P
L
I
P
P
R
---------------EE-
D
T
K
G
I
K
L
L
D
S
D
Q
E
L
Y
R
N
F
P
L
-
T
I
S
E
R
W
Q
Q
E
V
A
E
T
-
V
F
D
T
I
N
A
E
T
D
R
L
E
A
R
K
K
A
K
N
K
Q
L
G
H
E
E
D
Y
A
L
G
K
D
C
I
M
H
G
Y
M
S
K
M
W
Q
R
R
Y
F
Y
L
F
P
N
R
L
2
PsiBlast_PDB
62.91
100%
19
- C1 -
3NYO
2
GRK6_HUMAN
A:
[4-557]
-
E
L
E
N
I
V
A
N
T
V
L
L
K
A
R
E
G
--
G
G
G
N
R
K
G
K
S
K
K
W
R
Q
M
L
Q
F
P
H
I
S
Q
C
E
E
L
R
L
S
L
E
R
D
Y
H
S
L
C
E
R
---
Q
P
I
G
R
L
L
F
R
E
F
C
A
T
R
P
E
L
S
R
-
C
V
A
F
L
D
G
V
A
E
Y
E
-
V
T
P
D
D
K
R
K
A
C
G
R
Q
L
T
Q
N
F
L
-------
S
H
T
-
G
P
D
L
I
P
E
V
P
R
Q
L
V
T
N
C
T
Q
R
L
-
E
Q
G
P
C
K
-----
D
L
F
Q
E
L
T
R
L
T
H
E
Y
L
S
V
A
P
F
A
D
Y
L
D
S
I
Y
F
N
R
F
L
Q
W
K
W
L
E
R
Q
-
P
V
T
K
N
T
F
R
Q
Y
R
V
L
G
K
G
G
F
G
E
V
C
A
C
Q
V
---
R
A
-----
T
G
----
K
M
Y
A
C
K
K
L
E
K
K
R
I
-
K
K
-
R
K
---
G
E
A
M
A
L
N
E
K
Q
I
L
-
E
K
-
V
-
N
S
R
---
F
V
V
S
L
A
Y
A
Y
E
T
K
D
A
L
C
L
V
L
T
L
M
N
G
G
D
L
K
F
H
I
Y
H
M
G
--
Q
--
A
G
-
F
P
E
A
R
A
V
F
Y
A
A
E
I
C
C
G
L
E
D
L
H
R
E
R
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
D
H
G
----
H
I
R
I
S
D
L
G
L
---
A
V
H
-
V
-
P
E
G
Q
-
T
-
I
K
G
R
V
----
G
T
V
G
Y
M
A
P
E
V
V
-
K
N
E
R
Y
T
F
S
P
D
W
W
A
L
G
C
L
L
Y
E
M
I
A
G
Q
S
P
-
F
Q
----
K
K
I
K
R
E
E
V
E
R
L
V
K
E
----
V
P
E
E
Y
S
E
R
F
S
P
Q
A
R
S
L
C
S
Q
L
L
C
K
D
P
A
E
R
L
G
C
R
-
G
-
G
S
A
R
E
V
K
E
H
P
L
F
K
K
L
N
F
K
R
L
G
A
G
M
L
E
P
P
F
K
P
D
P
Q
A
I
Y
C
K
D
V
L
D
I
E
Q
F
S
---
T
V
K
G
V
E
L
E
P
T
D
Q
D
F
Y
Q
K
F
A
T
G
S
V
P
I
P
W
Q
N
E
M
V
E
T
E
C
F
Q
E
L
N
V
F
G
L
D
G
S
V
P
P
D
L
D
W
K
G
Q
P
P
A
P
P
K
K
G
L
L
Q
R
L
F
S
-------------------
1
PsiBlast_PDB
62.79
100%
20
- C1 -
3NYN
2
GRK6_HUMAN
A:
[4-557]
-
E
L
E
N
I
V
A
N
T
V
L
L
K
A
R
E
G
--
G
G
G
N
R
K
G
K
S
K
K
W
R
Q
M
L
Q
F
P
H
I
S
Q
C
E
E
L
R
L
S
L
E
R
D
Y
H
S
L
C
E
R
---
Q
P
I
G
R
L
L
F
R
E
F
C
A
T
R
P
E
L
S
R
-
C
V
A
F
L
D
G
V
A
E
Y
E
-
V
T
P
D
D
K
R
K
A
C
G
R
Q
L
T
Q
N
F
L
-------
S
H
T
-
G
P
D
L
I
P
E
V
P
R
Q
L
V
T
N
C
T
Q
R
L
-
E
Q
G
P
C
K
-----
D
L
F
Q
E
L
T
R
L
T
H
E
Y
L
S
V
A
P
F
A
D
Y
L
D
S
I
Y
F
N
R
F
L
Q
W
K
W
L
E
R
Q
-
P
V
T
K
N
T
F
R
Q
Y
R
V
L
G
K
G
G
F
G
E
V
C
A
C
Q
V
---
R
A
-----
T
G
----
K
M
Y
A
C
K
K
L
E
K
K
R
I
-
K
K
-
R
K
---
G
E
A
M
A
L
N
E
K
Q
I
L
-
E
K
-
V
-
N
S
R
---
F
V
V
S
L
A
Y
A
Y
E
T
K
D
A
L
C
L
V
L
T
L
M
N
G
G
D
L
K
F
H
I
Y
H
M
G
--
Q
--
A
G
-
F
P
E
A
R
A
V
F
Y
A
A
E
I
C
C
G
L
E
D
L
H
R
E
R
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
D
H
G
----
H
I
R
I
S
D
L
G
L
---
A
V
H
-
V
-
P
E
G
Q
-
T
-
I
K
G
R
V
----
G
T
V
G
Y
M
A
P
E
V
V
-
K
N
E
R
Y
T
F
S
P
D
W
W
A
L
G
C
L
L
Y
E
M
I
A
G
Q
S
P
-
F
Q
----
K
K
I
K
R
E
E
V
E
R
L
V
K
E
----
V
P
E
E
Y
S
E
R
F
S
P
Q
A
R
S
L
C
S
Q
L
L
C
K
D
P
A
E
R
L
G
C
R
-
G
-
G
S
A
R
E
V
K
E
H
P
L
F
K
K
L
N
F
K
R
L
G
A
G
M
L
E
P
P
F
K
P
D
P
Q
A
I
Y
C
K
D
V
L
D
I
E
Q
F
S
---
T
V
K
G
V
E
L
E
P
T
D
Q
D
F
Y
Q
K
F
A
T
G
S
V
P
I
P
W
Q
N
E
M
V
E
T
E
C
F
Q
E
L
N
V
F
G
L
D
G
S
V
P
P
D
L
D
W
K
G
Q
P
P
A
P
P
K
K
G
L
L
Q
R
L
F
S
-------------------
22
PsiBlast_CBE
62.50
100%
22
- C1 -
3NYN
2
GRK6_HUMAN
B:
[4-557]
-
E
L
E
N
I
V
A
N
T
V
L
L
K
A
R
E
G
--
G
G
G
N
R
K
G
K
S
K
K
W
R
Q
M
L
Q
F
P
H
I
S
Q
C
E
E
L
R
L
S
L
E
R
D
Y
H
S
L
C
E
R
---
Q
P
I
G
R
L
L
F
R
E
F
C
A
T
R
P
E
L
S
R
-
C
V
A
F
L
D
G
V
A
E
Y
E
-
V
T
P
D
D
K
R
K
A
C
G
R
Q
L
T
Q
N
F
L
-------
S
H
T
-
G
P
D
L
I
P
E
V
P
R
Q
L
V
T
N
C
T
Q
R
L
-
E
Q
G
P
C
K
-----
D
L
F
Q
E
L
T
R
L
T
H
E
Y
L
S
V
A
P
F
A
D
Y
L
D
S
I
Y
F
N
R
F
L
Q
W
K
W
L
E
R
Q
-
P
V
T
K
N
T
F
R
Q
Y
R
V
L
G
K
G
G
F
G
E
V
C
A
C
Q
V
---
R
A
-----
T
G
----
K
M
Y
A
C
K
K
L
E
K
K
R
I
-
K
K
-
R
K
---
G
E
A
M
A
L
N
E
K
Q
I
L
-
E
K
-
V
-
N
S
R
---
F
V
V
S
L
A
Y
A
Y
E
T
K
D
A
L
C
L
V
L
T
L
M
N
G
G
D
L
K
F
H
I
Y
H
M
G
--
Q
--
A
G
-
F
P
E
A
R
A
V
F
Y
A
A
E
I
C
C
G
L
E
D
L
H
R
E
R
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
D
H
G
----
H
I
R
I
S
D
L
G
L
---
A
V
H
-
V
-
P
E
G
Q
-
T
-
I
K
G
R
V
----
G
T
V
G
Y
M
A
P
E
V
V
-
K
N
E
R
Y
T
F
S
P
D
W
W
A
L
G
C
L
L
Y
E
M
I
A
G
Q
S
P
-
F
Q
----
K
K
I
K
R
E
E
V
E
R
L
V
K
E
----
V
P
E
E
Y
S
E
R
F
S
P
Q
A
R
S
L
C
S
Q
L
L
C
K
D
P
A
E
R
L
G
C
R
-
G
-
G
S
A
R
E
V
K
E
H
P
L
F
K
K
L
N
F
K
R
L
G
A
G
M
L
E
P
P
F
K
P
D
P
Q
A
I
Y
C
K
D
V
L
D
I
E
Q
F
S
---
T
V
K
G
V
E
L
E
P
T
D
Q
D
F
Y
Q
K
F
A
T
G
S
V
P
I
P
W
Q
N
E
M
V
E
T
E
C
F
Q
E
L
N
V
F
G
L
D
G
S
V
P
P
D
L
D
W
K
G
Q
P
P
A
P
P
K
K
G
L
L
Q
R
L
F
S
-------------------
40
PsiBlast_CBE
60.02
40%
-89
- C1 -
4MK0
1
ARBK1_HUMAN
A:
[32-502]
----------------------------------------------------------------
Q
K
L
G
Y
L
L
F
R
D
F
C
L
N
H
L
E
E
A
R
P
L
V
E
F
Y
E
E
I
K
K
Y
E
K
L
E
T
E
E
E
R
V
A
R
S
R
E
I
---
F
D
-------
S
Y
I
-
M
K
E
L
L
A
-
C
S
H
P
F
S
K
S
A
T
E
H
V
-
Q
G
H
L
G
K
KQVPP
D
L
F
Q
P
Y
I
E
E
I
C
Q
N
L
R
G
D
V
F
Q
K
F
I
E
S
D
K
F
T
R
F
C
Q
W
K
N
V
E
L
N
I
H
L
T
M
N
D
F
S
V
H
R
I
I
G
R
G
G
F
G
E
V
Y
G
C
R
K
---
A
D
-----
T
G
----
K
M
Y
A
M
K
C
L
D
K
K
R
I
-
K
M
-
K
Q
---
G
E
T
L
A
L
N
E
R
I
M
L
-
S
L
-
V
-
S
T
G
DCP
F
I
V
C
M
S
Y
A
F
H
T
P
D
K
L
S
F
I
L
D
L
M
N
G
G
D
L
H
---
Y
H
L
S
--
Q
--
H
G
V
F
S
E
A
D
M
R
F
Y
A
A
E
I
I
L
G
L
E
H
M
H
N
R
F
V
V
Y
R
D
L
K
P
A
N
I
L
L
D
E
H
G
----
H
V
R
I
S
D
L
G
L
---
A
C
D
-
F
-
S
K
K
K
-
P
--
H
A
S
V
----
G
T
H
G
Y
M
A
P
E
V
L
Q
K
G
V
A
Y
D
S
S
A
D
W
F
S
L
G
C
M
L
F
K
L
L
R
G
H
S
P
-
F
R
Q
H
K
-
T
K
D
K
H
-
E
I
D
R
M
T
L
T
----
M
A
V
E
L
P
D
S
F
S
P
E
L
R
S
L
L
E
G
L
L
Q
R
D
V
N
R
R
L
G
C
L
-
G
-
R
G
A
Q
E
V
K
E
S
P
F
F
R
S
L
D
W
Q
M
V
F
L
Q
K
Y
P
P
P
L
I
P
P
R
G
E
V
N
A
A
D
A
F
----------
T
K
G
I
K
L
L
D
S
D
Q
E
L
Y
R
N
F
P
L
-
T
I
S
E
R
W
Q
Q
E
V
A
E
T
-
V
F
D
T
I
N
A
E
T
D
R
L
E
A
R
K
K
A
K
N
K
Q
L
G
H
E
E
D
Y
A
L
G
K
D
C
I
M
H
G
Y
M
S
K
M
G
N
P
F
L
T
Q
W
Q
R
R
Y
F
109
HHSearch
52.08
34%
-93
- C1 -
4DC2
1
KPCI_MOUSE
A:
[49-372]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
L
Q
D
F
D
L
L
R
V
I
G
R
G
S
Y
A
K
V
L
L
V
R
L
---
K
K
-----
T
D
----
R
I
Y
A
M
R
V
V
K
K
E
L
V
-
N
--------
I
D
W
V
Q
T
E
K
H
V
F
-
E
Q
-
A
S
N
H
P
---
F
L
V
G
L
H
S
C
F
Q
T
E
S
R
L
F
F
V
I
E
Y
V
N
G
G
D
L
M
F
H
M
Q
R
Q
R
------
K
-
L
P
E
E
H
A
R
F
Y
S
A
E
I
S
L
A
L
N
Y
L
H
E
R
G
I
I
Y
R
D
L
K
L
D
N
V
L
L
D
S
E
G
----
H
I
K
L
T
D
Y
G
M
---
C
K
E
G
L
-
R
P
G
D
-
T
-
T
S
T
F
C
----
G
T
P
N
Y
I
A
P
E
I
L
-
R
G
E
D
Y
G
F
S
V
D
W
W
A
L
G
V
L
M
F
E
M
M
A
G
R
S
P
-
F
D
I
V
G
S--
N
T
E
D
Y
L
F
Q
V
I
L
E
----
K
Q
I
R
I
P
R
S
L
S
V
K
A
A
S
V
L
K
S
F
L
N
K
D
P
K
E
R
L
G
C
H
P
Q
-
T
G
F
A
D
I
Q
G
H
P
F
F
R
N
V
D
W
D
M
M
E
Q
K
Q
V
V
P
P
F
K
P
N
I
-----
S
G
E
F
G
L
D
N
F
D
SQF
T
N
E
P
V
Q
L
T
P
D
D
D
D
I
V
R
K
I
D
Q
S
E
F
E
G
F
E
Y
I
N
P
-------------------------------------------------------------
21
PsiBlast_CBE
51.34
100%
18
- C1 -
3NYO
2
GRK6_HUMAN
B:
[4-557]
-
E
L
E
N
I
V
A
N
T
V
L
L
K
A
R
E
G
--
G
G
G
N
R
K
G
K
S
K
K
W
R
Q
M
L
Q
F
P
H
I
S
Q
C
E
E
L
R
L
S
L
E
R
D
Y
H
S
L
C
E
R
---
Q
P
I
G
R
L
L
F
R
E
F
C
A
T
R
P
E
L
S
R
-
C
V
A
F
L
D
G
V
A
E
Y
E
-
V
T
P
D
D
K
R
K
A
C
G
R
Q
L
T
Q
N
F
L
-------
S
H
T
-
G
P
D
L
I
P
E
V
P
R
Q
L
V
T
N
C
T
Q
R
L
-
E
Q
G
P
C
K
-----
D
L
F
Q
E
L
T
R
L
T
H
E
Y
L
S
V
A
P
F
A
D
Y
L
D
S
I
Y
F
N
R
F
L
Q
W
K
W
L
E
R
Q
-
P
V
T
K
N
T
F
R
Q
Y
R
V
L
G
K
G
G
F
G
E
V
C
A
C
Q
V
---
R
A
-----
T
G
----
K
M
Y
A
C
K
K
L
E
K
K
R
I
-
K
K
-
R
K
---
G
E
A
M
A
L
N
E
K
Q
I
L
-
E
K
-
V
-
N
S
R
---
F
V
V
S
L
A
Y
A
Y
E
T
K
D
A
L
C
L
V
L
T
L
M
N
G
G
D
L
K
F
H
I
Y
H
M
G
--
Q
--
A
G
-
F
P
E
A
R
A
V
F
Y
A
A
E
I
C
C
G
L
E
D
L
H
R
E
R
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
D
H
G
----
H
I
R
I
S
D
L
G
L
---
A
V
H
-
V
-
P
E
G
Q
-
T
-
I
K
G
R
V
----
G
T
V
G
Y
M
A
P
E
V
V
-
K
N
E
R
Y
T
F
S
P
D
W
W
A
L
G
C
L
L
Y
E
M
I
A
G
Q
S
P
-
F
Q
----
K
K
I
K
R
E
E
V
E
R
L
V
K
E
----
V
P
E
E
Y
S
E
R
F
S
P
Q
A
R
S
L
C
S
Q
L
L
C
K
D
P
A
E
R
L
G
C
R
-
G
-
G
S
A
R
E
V
K
E
H
P
L
F
K
K
L
N
F
K
R
L
G
A
G
M
L
E
P
P
F
K
P
D
P
Q
A
I
Y
C
K
D
V
L
D
I
E
Q
F
S
---
T
V
K
G
V
E
L
E
P
T
D
Q
D
F
Y
Q
K
F
A
T
G
S
V
P
I
P
W
Q
N
E
M
V
E
T
E
C
F
Q
E
L
N
V
F
G
L
D
G
S
V
P
P
D
L
D
W
K
G
Q
P
P
A
P
P
K
K
G
L
L
Q
R
L
F
S
-------------------
57
PsiBlast_CBE
50.19
36%
-98
- C1 -
4RA5
1
B:
[7-280]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
L
H
K
M
L
G
K
G
S
F
G
K
V
F
L
A
E
F
---
K
K
-----
T
N
----
Q
F
F
A
I
K
A
L
K
K
D
V
V
-
L
M
-
D
D
---
D
V
E
C
T
M
V
E
K
R
V
L
-
S
L
-
A
-
W
E
H
P--
F
L
T
H
M
F
C
T
F
Q
T
K
E
N
L
F
F
V
M
E
Y
L
N
G
G
D
L
M
Y
H
I
Q
S
C
H
--
K
-----
F
D
L
S
R
A
T
F
Y
A
A
E
I
I
L
G
L
Q
F
L
H
S
K
G
I
V
Y
R
D
L
K
L
D
N
I
L
L
D
K
D
G
----
H
I
K
I
A
D
F
G
M
---
C
K
E
-
N
-
M
L
G
D
-
A
-
K
T
N
E
F
C---
G
T
P
D
Y
I
A
P
E
I
L
-
L
G
Q
K
Y
N
H
S
V
D
W
W
S
F
G
V
L
L
Y
E
M
L
I
G
Q
S
P
-
F
H
G
Q
D
-
E
----
E
E
L
F
H
S
I
R
M
----
D
N
P
F
Y
P
R
W
L
E
K
E
A
K
D
L
L
V
K
L
F
V
R
E
P
E
K
R
L
G
V
R
-
G
-----
D
I
R
Q
H
P
L
F
R
E
I
N
W
E
E
L
E
R
K
E
I
D
P
P
F
R
P
K
V
K
S
P
F
D
P
R
L
S
R
A
L
I
N
S
---
M
D
Q
N
M
F
R
N
F
S
F
M
N
P
G
M
----------------------------------------------------------------------------
110
HHSearch
49.44
32%
-89
- C1 -
1RDQ
3
KAPCA_MOUSE
E:
[28-333]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
K
W
E
T
P
S
Q
N
-
T
A
Q
L
D
Q
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
---
K
E
-----
S
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
-
V
K
-
L
K
---
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
A
-
V
-
N
F
P
---
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
G
------
R
-
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
----
Y
I
Q
V
T
D
F
G
F
---
A
K
R
-
V
-
K
G
R
----
T
W
T
L
C
----
G
T
P
E
A
L
A
P
E
I
I
-
L
S
K
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
-
F
F
A
D
Q
-----
P
I
Q
I
Y
E
K
I
V
S
----
G
K
V
R
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
L
-
K
-
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
-----
G
P
G
D
T
S
N
F
D
---
D
Y
E
E
E
E
I
R
V
S
I
N
E
K
C
G
K
E
F
T
E
F
----------------------------------------------------------------------
59
PsiBlast_CBE
48.76
36%
-97
- C1 -
4Q9Z
1
B:
[7-280]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
L
H
K
M
L
G
K
G
S
F
G
K
V
F
L
A
E
F
---
K
K
-----
T
N
----
Q
F
F
A
I
K
A
L
K
K
D
V
V
-
L
M
-
D
D
---
D
V
E
C
T
M
V
E
K
R
V
L
-
S
L
-
A
-
W
E
H
P--
F
L
T
H
M
F
C
T
F
Q
T
K
E
N
L
F
F
V
M
E
Y
L
N
G
G
D
L
M
Y
H
I
Q
S
C
H
--
K
-----
F
D
L
S
R
A
T
F
Y
A
A
E
I
I
L
G
L
Q
F
L
H
S
K
G
I
V
Y
R
D
L
K
L
D
N
I
L
L
D
K
D
G
----
H
I
K
I
A
D
F
G
M
---
C
K
E
-
N
-
M
L
G
D
-
A
-
K
T
N
E
F
C
---
G
T
P
D
Y
I
A
P
E
I
L
-
L
G
Q
K
Y
N
H
S
V
D
W
W
S
F
G
V
L
L
Y
E
M
L
I
G
Q
S
P
-
F
H
G
Q
D
-
E
----
E
E
L
F
H
S
I
R
M
----
D
N
P
F
Y
P
R
W
L
E
K
E
A
K
D
L
L
V
K
L
F
V
R
E
P
E
K
R
L
G
V
R
-
G
-----
D
I
R
Q
H
P
L
F
R
E
I
N
W
E
E
L
E
R
K
E
I
D
P
P
F
R
P
K
V
K
S
P
F
D
C
S
N
F
D
K
N
M
F
R
---
N
F
S
F
M
N
P
G
M
E
R
L
--------------------------------------------------------------------------------
116
HHSearch
48.72
40%
-104
- C1 -
2R5T
1
SGK1_HUMAN
A:
[34-318]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
A
K
P
S
D
F
H
F
L
K
V
I
G
K
G
S
F
G
K
V
L
L
A
R
H
---
K
A
-----
E
E
----
V
F
Y
A
V
K
V
L
Q
K
K
A
I
-
L
-----------------
V
L
L
K
N
-
V
-
K
H
P
---
F
L
V
G
L
H
F
S
F
Q
T
A
D
K
L
Y
F
V
L
D
Y
I
N
G
G
E
L
F
Y
H
L
Q
R
E
------
R
C
-
F
L
E
P
R
A
R
F
Y
A
A
E
I
A
S
A
L
G
Y
L
H
S
L
N
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
S
Q
G
----
H
I
V
L
T
D
F
G
L
---
C
K
E
-
N
I
E
H
N
S
-
T
-
T
S
T
F
C
----
G
T
P
E
Y
L
A
P
E
V
L
-
H
K
Q
P
Y
D
R
T
V
D
W
W
C
L
G
A
V
L
Y
E
M
L
Y
G
L
P
P
-
F
Y
S
R
N
-----
T
A
E
M
Y
D
N
I
L
N
----
K
P
L
Q
L
K
P
N
I
T
N
S
A
R
H
L
L
E
G
L
L
Q
K
D
R
T
K
R
L
G
A
--
K
-
D
D
F
M
E
I
K
S
H
V
F
F
S
L
I
N
W
D
D
L
I
N
K
K
I
T
P
P
F
N
P
N
V
S
G
------------------------------------------------------------------------------------------------------------
127
HHSearch
48.00
38%
-95
- C1 -
3UBD
1
KS6A3_MOUSE
A:
[21-304]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
P
S
Q
F
E
L
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
V
K
K
---
I
S
GSD--
A
R
----
Q
L
Y
A
M
K
V
L
K
K
A
T
L
-
K
V
--
R
---
D
R
V
------
D
I
L
-
V
E
-
V
-
N
H
P
---
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
----
E
--
V
M
-
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
S
L
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
G
----
H
I
K
L
T
D
F
G
L
---
S
K
------
E
K
-
K
-
A
Y
S
F
C
----
G
T
V
E
Y
M
A
P
E
V
V
-
N
R
R
G
H
T
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
T
L
P
-
F
Q
G
K
D
-----
R
K
E
T
M
T
M
I
L
K
----
A
K
L
G
M
P
Q
F
L
S
P
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
R
L
G
A
G
-
P
-
D
G
V
E
E
I
K
R
H
S
F
F
S
T
I
D
W
N
K
L
Y
R
R
E
I
H
P
P
F
K
P
----------------------------------------------------------------------------------------------------------------
72
PsiBlast_CBE
47.46
37%
-99
- C1 -
4NUS
1
KS6A3_HUMAN
A:
[32-310]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
L
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
V
K
----
K
I
-----
S
G
SDAR
Q
L
Y
A
M
K
V
L
K
K
A
T
L
-
K
V
-
R
D
---
R
V
R
T
K
M
-
E
R
D
I
L
-
V
E
-
V
-
N
H
P
---
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
----
E
--
V
M
-
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
S
L
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
G
----
H
I
K
L
T
D
F
G
L
---
S
K
E
S
I
-
D
H
E
K
-
K
-
A
Y
S
F
C
----
G
T
V
E
Y
M
A
P
E
V
V
-
N
R
R
G
H
T
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
T
L
P
-
F
Q
G
K
D
-
R
K
----
E
T
M
T
M
I
L
K
----
A
K
L
G
M
P
Q
F
L
S
P
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
R
L
G
A
G
-
P
-
D
G
V
E
E
I
K
R
H
S
F
F
S
T
I
D
W
N
K
L
Y
R
R
E
I
H
P
P
F
K
P
A
T
F
Y
F
D
P
---------------------------------------------------------------------------------------------------------
113
HHSearch
47.36
37%
-98
- C1 -
3TXO
1
A:
[23-305]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
N
F
E
F
I
R
V
L
G
K
G
S
F
G
K
V
M
L
A
R
V
---
K
E
-----
T
G
----
D
L
Y
A
V
K
V
L
K
K
D
V
I
-
L
Q
-
D
D
---
D
V
E
C
T
M
T
E
K
R
I
L
-
S
L
-
A
R
N
H
P
---
F
L
T
Q
L
F
C
C
F
Q
T
P
D
R
L
F
F
V
M
E
F
V
N
G
G
D
L
M
F
H
I
Q
K
S
R
------
R
-
F
D
E
A
R
A
R
F
Y
A
A
E
I
I
S
A
L
M
F
L
H
D
K
G
I
I
Y
R
D
L
K
L
D
N
V
L
L
D
H
E
G
----
H
C
K
L
A
D
F
G
M
---
C
K
E
-
G
I
C
---------------
G
T
P
D
Y
I
A
P
E
I
L
-
Q
E
M
L
Y
G
P
A
V
D
W
W
A
M
G
V
L
L
Y
E
M
L
C
G
H
A
P
-
F
E
A
E
N
-----
E
D
D
L
F
E
A
I
L
N
----
D
E
V
V
Y
P
T
W
L
H
E
D
A
T
G
I
L
K
S
F
M
T
K
N
P
T
M
R
L
G
S
L
-
T
Q
G
G
E
H
A
I
L
R
H
P
F
F
K
E
I
D
W
A
Q
L
N
H
R
Q
I
E
P
P
F
R
P
R
I
K
S
R
E
D
V
S
N
F
D
P
D
F
I
K
---
E
E
P
V
L
T
P
I
D
E
G
H
L
P
M
I
N
Q
D
E
F
R
N
F
E
Y
V
S
P
---------------------------------------------------------------
69
PsiBlast_CBE
47.17
37%
-101
- C1 -
5D9L
2
?
A:
[32-310]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
L
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
V
K
----
K
I
-----
S
G
SDAR
Q
L
Y
A
M
K
V
L
K
K
A
T
L
-
K
V
-
R
D
---
R
V
R
T
K
M
-
E
R
D
I
L
-
V
E
-
V
-
N
H
P
---
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
----
E
--
V
M
-
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
S
L
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
G
----
H
I
K
L
T
D
F
G
L
---
S
K
E
-------------------
G
T
V
E
Y
M
A
P
E
V
V
-
N
R
R
G
H
T
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
T
L
P
-
F
Q
G
K
D
-
R
K
----
E
T
M
T
M
I
L
K
----
A
K
L
G
M
P
Q
F
L
S
P
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
R
L
G
A
G
-
P
-
D
G
V
E
E
I
K
R
H
S
F
F
S
T
I
D
W
N
K
L
Y
R
R
E
I
H
P
P
F
K
P
A
T
G
R
P
E
D
T
F
Y
F
D
P
---------------------------------------------------------------------------------------------------
67
PsiBlast_CBE
47.01
37%
-103
- C1 -
5D9K
2
?
B:
[32-310]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
L
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
V
K
----
K
I
-----
S
G
SDAR
Q
L
Y
A
M
K
V
L
K
K
A
T
L
-
K
V
-
R
D
---
R
V
R
T
K
M
-
E
R
D
I
L
-
V
E
-
V
-
N
H
P
---
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
----
E
--
V
M
-
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
S
L
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
G
----
H
I
K
L
T
D
F
G
L
---
S
K
E
--------------
C
----
G
T
V
E
Y
M
A
P
E
V
V
-
N
R
R
G
H
T
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
T
L
P
-
F
Q
G
K
D
-
R
K
----
E
T
M
T
M
I
L
K
----
A
K
L
G
M
P
Q
F
L
S
P
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
R
L
G
A
G
-
P
-
D
G
V
E
E
I
K
R
H
S
F
F
S
T
I
D
W
N
K
L
Y
R
R
E
I
H
P
P
F
K
P
T
F
Y
F
D
P
----------------------------------------------------------------------------------------------------------
68
PsiBlast_CBE
46.89
37%
-104
- C1 -
5D9K
2
?
A:
[32-310]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
L
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
V
K
----
K
I
-----
S
G
SDAR
Q
L
Y
A
M
K
V
L
K
K
A
T
L
-
K
V
-
R
D
---
R
V
R
T
K
M
-
E
R
D
I
L
-
V
E
-
V
-
N
H
P
---
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
----
E
--
V
M
-
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
S
L
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
G
----
H
I
K
L
T
D
F
G
L
---
S
K
---------------
C
----
G
T
V
E
Y
M
A
P
E
V
V
-
N
R
R
G
H
T
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
T
L
P
-
F
Q
G
K
D
-
R
K
----
E
T
M
T
M
I
L
K
----
A
K
L
G
M
P
Q
F
L
S
P
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
R
L
G
A
G
-
P
-
D
G
V
E
E
I
K
R
H
S
F
F
S
T
I
D
W
N
K
L
Y
R
R
E
I
H
P
P
F
K
P
A
T
F
Y
F
D
P
---------------------------------------------------------------------------------------------------------
76
PsiBlast_CBE
46.68
37%
-94
- C1 -
3UBD
1
KS6A3_MOUSE
A:
[24-304]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
Q
F
E
L
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
V
K
----
K
I
-----
S
G
SDAR
Q
L
Y
A
M
K
V
L
K
K
A
T
L
-
K
V
-
R
D
---
R
V
-------
D
I
L
-
V
E
-
V
-
N
H
P
---
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
----
E
--
V
M
-
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
S
L
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
G
----
H
I
K
L
T
D
F
G
L
---
S
K
E
------
K
-
K
-
A
Y
S
F
C
----
G
T
V
E
Y
M
A
P
E
V
V
-
N
R
R
G
H
T
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
T
L
P
-
F
Q
G
K
D
-
R
K
----
E
T
M
T
M
I
L
K
----
A
K
L
G
M
P
Q
F
L
S
P
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
R
L
G
A
G
-
P
-
D
G
V
E
E
I
K
R
H
S
F
F
S
T
I
D
W
N
K
L
Y
R
R
E
I
H
P
P
F
K
P
----------------------------------------------------------------------------------------------------------------
85
PsiBlast_CBE
46.55
34%
-87
- C1 -
2UZW
1
KAPCA_BOVIN
E:
[27-302]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
---
M
E
-----
T
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
-
V
K
-
L
K
---
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
A
-
V
-
N
F
P
---
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
--
R
--
F
S
-
E
P
H
A
R
--
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
----
Y
I
Q
V
T
D
F
G
F
---
A
--------
K
-
R
-
V
K
G
R
T
WTLC
G
T
P
E
Y
L
A
P
E
I
I
-
L
S
K
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
-
I
Q
I
Y
E
K
I
V
S
G
K
V
R
---------
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
L
-
K
-
D
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
---
E
I
R
V
S
I
N
E
K
C
G
K
E
F
S
E
F
---------------------------------------------------------------------------
63
PsiBlast_CBE
46.52
39%
-104
- C1 -
2R5T
1
SGK1_HUMAN
A:
[40-317]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
H
F
L
K
V
I
G
K
G
S
F
G
K
V
L
L
A
R
H
---
K
A
-----
E
E
----
V
F
Y
A
V
K
V
L
Q
K
K
A
I
-
L
-----------------
V
L
-
L
K
N
V
-
K
H
P
---
F
L
V
G
L
H
F
S
F
Q
T
A
D
K
L
Y
F
V
L
D
Y
I
N
G
G
E
L
F
Y
H
L
--
Q
R
--
E
--
R
C
-
F
L
E
P
R
A
R
F
Y
A
A
E
I
A
S
A
L
G
Y
L
H
S
L
N
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
S
Q
G
----
H
I
V
L
T
D
F
G
L
C--
K
E
N
-
I
-
E
H
N
S
-
T
-
T
S
T
F
C
----
G
T
P
E
Y
L
A
P
E
V
L
-
H
K
Q
P
Y
D
R
T
V
D
W
W
C
L
G
A
V
L
Y
E
M
L
Y
G
L
P
P
-
F
Y
S
R
N
-
T
A
----
E
M
Y
D
N
I
L
N
----
K
P
L
Q
L
K
P
N
I
T
N
S
A
R
H
L
L
E
G
L
L
Q
K
D
R
T
K
R
L
G
A
K
---
D
D
F
M
E
I
K
S
H
V
F
F
S
L
I
N
W
D
D
L
I
N
K
K
I
T
P
P
F
N
P
N
V
S
G
------------------------------------------------------------------------------------------------------------
71
PsiBlast_CBE
46.42
37%
-94
- C1 -
4NW5
1
KS6A3_HUMAN
A:
[32-310]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
L
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
V
K
----
K
I
-----
S
G
SDAR
Q
L
Y
A
M
K
V
L
K
K
A
T
L
-
K
V
-
R
D
---
R
V
R
T
K
M
-
E
R
D
I
L
-
V
E
-
V
-
N
H
P
---
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
----
E
--
V
M
-
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
S
L
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
G
----
H
I
K
L
T
D
F
G
L
---
S
K
E
S
I
-
D
H
E
K
-
K
-
A
Y
S
F
C
----
G
T
V
E
Y
M
A
P
E
V
V
-
N
R
R
G
H
T
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
T
L
P
-
F
Q
G
K
D
-
R
K
----
E
T
M
T
M
I
L
K
----
A
K
L
G
M
P
Q
F
L
S
P
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
R
L
G
A
G
-
P
-
D
G
V
E
E
I
K
R
H
S
F
F
S
T
I
D
W
N
K
L
Y
R
R
E
I
H
P
P
F
K
P
T
F
Y
F
D
P
----------------------------------------------------------------------------------------------------------
73
PsiBlast_CBE
46.36
37%
-99
- C1 -
3G51
1
KS6A3_MOUSE
A:
[26-304]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
L
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
V
K
----
K
I
-----
S
G
SDAR
Q
L
Y
A
M
K
V
L
K
K
A
T
L
-
K
V
-
R
D
-------------
I
L
-
V
E
-
V
-
N
H
P
---
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
----
E
--
V
M
-
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
S
L
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
G
----
H
I
K
L
T
D
F
G
L
---
S
K
E
S
I
------------------
T
V
E
Y
M
A
P
E
V
V
-
N
R
R
G
H
T
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
T
L
P
-
F
Q
G
K
D
-
R
K
----
E
T
M
T
M
I
L
K
----
A
K
L
G
M
P
Q
F
L
S
P
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
R
L
G
A
G
-
P
-
D
G
V
E
E
I
K
R
H
S
F
F
S
T
I
D
W
N
K
L
Y
R
R
E
I
H
P
P
F
K
P
----------------------------------------------------------------------------------------------------------------
70
PsiBlast_CBE
46.26
37%
-94
- C1 -
4NW6
1
KS6A3_HUMAN
A:
[32-310]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
L
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
V
K
----
K
I
-----
S
G
SDAR
Q
L
Y
A
M
K
V
L
K
K
A
T
L
-
K
V
-
R
D
---
R
V
R
T
K
M
-
E
R
D
I
L
-
V
E
-
V
-
N
H
P
---
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
----
E
--
V
M
-
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
S
L
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
G
----
H
I
K
L
T
D
F
G
L
---
S
K
E
S
I
-
D
H
E
K
-
K
-
A
Y
S
F
C
----
G
T
V
E
Y
M
A
P
E
V
V
-
N
R
R
G
H
T
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
T
L
P
-
F
Q
G
K
D
-
R
K
----
E
T
M
T
M
I
L
K
----
A
K
L
G
M
P
Q
F
L
S
P
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
R
L
G
A
G
-
P
-
D
G
V
E
E
I
K
R
H
S
F
F
S
T
I
D
W
N
K
L
Y
R
R
E
I
H
P
P
F
K
P
T
F
Y
F
D
P
----------------------------------------------------------------------------------------------------------
64
PsiBlast_CBE
46.25
38%
-105
- C1 -
2Z7S
1
KS6A1_HUMAN
A:
[30-308]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
L
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
V
R
K
---
V
T
RPD--
S
G
----
H
L
Y
A
M
K
V
L
K
-----------------------
I
L
-
A
D
-
V
-
N
H
P
---
F
V
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
--
S
K
--
E
--
V
M
-
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
G
L
D
H
L
H
S
L
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
G
----
H
I
K
L
T
D
F
G
L
---
S
K
E
-------------------
G
T
V
E
Y
M
A
P
E
V
V
-
N
R
Q
G
H
S
H
S
A
D
W
W
S
Y
G
V
L
M
F
E
M
L
T
G
S
L
P
-
F
Q
G
K
-----
D
R
K
E
T
M
T
L
I
L
K
----
A
K
L
G
M
P
Q
F
L
S
T
E
A
Q
S
L
L
R
A
L
F
K
R
N
P
A
N
R
L
G
S
G
-
P
-
D
G
A
E
E
I
K
R
H
V
F
Y
S
T
I
D
W
N
K
L
Y
R
R
E
I
K
P
P
F
K
P
----------------------------------------------------------------------------------------------------------------
41
PsiBlast_CBE
46.19
39%
-95
- C1 -
4L45
1
KS6B1_HUMAN
A:
[20-304]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
L
L
R
V
L
G
K
G
G
Y
G
K
V
F
--
Q
V
---
R
K
VTGAN
T
G
----
K
I
F
A
M
K
V
L
K
K
A
M
I
V
R
N
-
A
K
---
D
T
A
H
T
K
A
E
R
N
I
L
-
E
E
-
V
-
K
H
P
---
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
E
G
--
I
-----
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
K
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
H
Q
G
----
H
V
K
L
T
D
F
G
L
CKE
S
---------------------
G
T
I
E
Y
M
A
P
E
I
L
-
M
R
S
G
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
P
P
-
F
T
G
E
N
-
R
K
K
T
I
D
K
I
L
K
C
K
L
N
----
L
P
P
Y
L
T
Q
----
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
R
L
G
A
G
-
P
-
G
D
A
G
E
V
Q
A
H
P
F
F
R
H
I
N
W
E
E
L
L
A
R
K
V
E
P
P
F
K
P
L
L
Q
S
E
E
D
V
S
Q
F
D
S
K
F
T
R
---
Q
T
P
V
E
S
A
N
Q
V
F
L
G
F
E
Y
V
A
P
S
------------------------------------------------------------------------
89
PsiBlast_CBE
46.15
34%
-88
- C1 -
2OJF
1
KAPCA_BOVIN
E:
[42-317]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
---
M
E
-----
T
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
-
V
K
-
L
K
---
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
A
-
V
-
N
F
P
---
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
--
R
--
F
S
-
E
P
H
A
R
--
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
----
Y
I
Q
V
T
D
F
G
F
---
A
--------
K
-
R
-
V
K
G
R
T
WTLC
G
T
P
E
Y
L
A
P
E
I
I
-
L
S
K
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
-
I
Q
I
Y
E
K
I
V
S
G
K
V
R
---------
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
L
-
K
-
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
---
E
I
R
V
S
I
N
E
K
C
G
K
E
F
S
E
F
---------------------------------------------------------------------------
75
PsiBlast_CBE
46.04
37%
-94
- C1 -
4EL9
1
KS6A3_MOUSE
A:
[25-305]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
Q
F
E
L
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
V
K
----
K
I
-----
S
G
SDAR
Q
L
Y
A
M
K
V
L
K
K
A
T
L
-
K
V
-
R
D
---
R
V
R
------
D
I
L
-
V
E
-
V
-
N
H
P
---
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
----
E
--
V
M
-
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
S
L
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
G
----
H
I
K
L
T
D
F
G
L
---
S
K
E
S----
E
K
-
K
-
A
Y
S
F
C
----
G
T
V
E
Y
M
A
P
E
V
V
-
N
R
R
G
H
T
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
T
L
P
-
F
Q
G
K
D
-
R
K
----
E
T
M
T
M
I
L
K
----
A
K
L
G
M
P
Q
F
L
S
P
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
R
L
G
A
G
-
P
-
D
G
V
E
E
I
K
R
H
S
F
F
S
T
I
D
W
N
K
L
Y
R
R
E
I
H
P
P
F
K
P
----------------------------------------------------------------------------------------------------------------
120
HHSearch
45.99
38%
-94
- C1 -
3WF7
2
KS6B1_HUMAN
A:
[14-304]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
-
K
I
R
P
E
C
F
E
L
L
R
V
L
G
K
G
G
Y
G
K
V
F
Q
V
R
K
VTG
A
N
-----
T
G
----
K
I
F
A
M
K
V
L
K
K
A
M
I
-
V
R
N
A
K
---
D
T
A
H
T
K
A
E
R
N
I
L
-
E
E
-
V
-
K
H
P
---
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
E
G
------
I
-
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
K
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
H
Q
G
----
H
V
K
L
T
D
F
G
L
---
C
K
E
-
S
I
H
D
-----
T
H
T
F
C
----
G
T
I
E
Y
M
A
P
E
I
L
-
M
R
S
G
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
P
P
-
F
T
G
E
N
-
R
----
K
K
T
I
D
K
I
L
K
----
C
K
L
N
L
P
P
Y
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
R
L
G
A
G
-
P
-
G
D
A
G
E
V
Q
A
H
P
F
F
R
H
I
N
W
E
E
L
L
A
R
K
V
E
P
P
F
K
P
L
L
Q
-------------------------------------------------------------------------------------------------------------
43
PsiBlast_CBE
45.92
39%
-92
- C1 -
4L43
1
KS6B1_HUMAN
A:
[20-304]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
L
L
R
V
L
G
K
G
G
Y
G
K
V
F
--
Q
V
---
R
K
VTGAN
T
G
----
K
I
F
A
M
K
V
L
K
K
A
M
I
V
R
N
-
A
K
---
D
T
A
H
T
K
A
E
R
N
I
L
-
E
E
-
V
-
K
H
P
---
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
E
G
--
I
-----
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
K
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
H
Q
G
----
H
V
K
L
T
D
F
G
L
C
K
E
S
---------------------
G
T
I
E
Y
M
A
P
E
I
L
-
M
R
S
G
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
P
P
-
F
T
G
E
N
-
R
K
K
T
I
D
K
I
L
K
C
K
L
N
----
L
P
P
Y
L
T
Q
----
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
R
L
G
A
G
-
P
-
G
D
A
G
E
V
Q
A
H
P
F
F
R
H
I
N
W
E
E
L
L
A
R
K
V
E
P
P
F
K
P
L
L
Q
S
E
E
D
V
S
Q
F
D
S
K
F
T
R
---
Q
T
P
V
S
A
N
Q
V
F
L
G
F
A
Y
V
A
P
S
-------------------------------------------------------------------------
90
PsiBlast_CBE
45.87
34%
-89
- C1 -
2OH0
1
KAPCA_BOVIN
E:
[42-317]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
---
M
E
-----
T
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
-
V
K
-
L
K
---
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
A
-
V
-
N
F
P
---
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
--
R
--
F
S
-
E
P
H
A
R
--
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
----
Y
I
Q
V
T
D
F
G
F
---
A
--------
K
-
R
-
V
K
G
R
T
WTLC
G
T
P
E
Y
L
A
P
E
I
I
-
L
S
K
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
-
I
Q
I
Y
E
K
I
V
S
G
K
V
R
---------
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
L
-
K
-
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
---
E
I
R
V
S
I
N
E
K
C
G
K
E
F
S
E
F
---------------------------------------------------------------------------
66
PsiBlast_CBE
45.71
38%
-107
- C1 -
2Z7Q
1
KS6A1_HUMAN
A:
[30-308]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
L
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
V
R
K
---
V
T
RPD--
S
G
----
H
L
Y
A
M
K
V
L
------------------------
I
L
-
A
D
-
V
-
N
H
P
---
F
V
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
--
S
K
--
E
--
V
M
-
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
G
L
D
H
L
H
S
L
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
G
----
H
I
K
L
T
D
F
G
L
---
S
K
E
-------------------
G
T
V
E
Y
M
A
P
E
V
V
-
N
R
Q
G
H
S
H
S
A
D
W
W
S
Y
G
V
L
M
F
E
M
L
T
G
S
L
P
-
F
Q
G
K
-----
D
R
K
E
T
M
T
L
I
L
K
----
A
K
L
G
M
P
Q
F
L
S
T
E
A
Q
S
L
L
R
A
L
F
K
R
N
P
A
N
R
L
G
S
G
-
P
-
D
G
A
E
E
I
K
R
H
V
F
Y
S
T
I
D
W
N
K
L
Y
R
R
E
I
K
P
P
F
K
P
----------------------------------------------------------------------------------------------------------------
93
PsiBlast_CBE
45.61
34%
-88
- C1 -
2F7E
1
KAPCA_BOVIN
E:
[42-317]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
---
M
E
-----
T
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
-
V
K
-
L
K
---
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
A
-
V
-
N
F
P
---
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
--
R
--
F
S
-
E
P
H
A
R
--
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
----
Y
I
Q
V
T
D
F
G
F
---
A
--------
K
-
R
-
V
K
G
R
T
WTLC
G
T
P
E
Y
L
A
P
E
I
I
-
L
S
K
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
-
I
Q
I
Y
E
K
I
V
S
G
K
V
R
---------
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
L
-
K
-
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
---
E
I
R
V
S
I
N
E
K
C
G
K
E
F
S
E
F
---------------------------------------------------------------------------
65
PsiBlast_CBE
45.47
38%
-101
- C1 -
2Z7R
1
KS6A1_HUMAN
A:
[30-308]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
L
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
V
R
K
---
V
T
RPD--
S
G
----
H
L
Y
A
M
K
V
L
K
K
A
T
L
-
K
V
----------------
I
L
-
A
D
-
V
-
N
H
P
---
F
V
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
--
S
K
--
E
--
V
M
-
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
G
L
D
H
L
H
S
L
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
G
----
H
I
K
L
T
D
F
G
L
---
S
K
E
-------------------
G
T
V
E
Y
M
A
P
E
V
V
-
N
R
Q
G
H
S
H
S
A
D
W
W
S
Y
G
V
L
M
F
E
M
L
T
G
S
L
P
-
F
Q
G
K
-----
D
R
K
E
T
M
T
L
I
L
K
----
A
K
L
G
M
P
Q
F
L
S
T
E
A
Q
S
L
L
R
A
L
F
K
R
N
P
A
N
R
L
G
S
G
-
P
-
D
G
A
E
E
I
K
R
H
V
F
Y
S
T
I
D
W
N
K
L
Y
R
R
E
I
K
P
P
F
K
P
----------------------------------------------------------------------------------------------------------------
88
PsiBlast_CBE
45.38
34%
-90
- C1 -
2UZT
1
KAPCA_BOVIN
A:
[27-302]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
---
M
E
-----
T
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
-
V
K
-
L
K
---
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
A
-
V
-
N
F
P
---
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
--
R
--
F
S
-
E
P
H
A
R
--
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
----
Y
I
Q
V
T
D
F
G
F
---
A
--------
K
-
R
-
V
K
G
R
T
W
T
LC
G
T
P
E
Y
L
A
P
E
I
I
-
L
S
K
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
-
I
Q
I
Y
E
K
I
V
S
G
K
V
R
---------
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
L
-
K
-
D
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
---
E
I
R
V
S
I
N
E
K
C
G
K
E
F
S
E
F
---------------------------------------------------------------------------
87
PsiBlast_CBE
45.34
34%
-92
- C1 -
2UZU
1
KAPCA_BOVIN
E:
[27-302]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
---
M
E
-----
T
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
-
V
K
-
L
K
---
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
A
-
V
-
N
F
P
---
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
--
R
--
F
S
-
E
P
H
A
R
--
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
----
Y
I
Q
V
T
D
F
G
F
---
A
--------
K
-
R
-
V
K
G
R
T
WTLC
G
T
P
E
Y
L
A
P
E
I
I
-
L
S
K
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
-
I
Q
I
Y
E
K
I
V
S
G
K
V
R
---------
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
L
-
K
-
D
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
---
E
I
R
V
S
I
N
E
K
C
G
K
E
F
S
E
F
---------------------------------------------------------------------------
91
PsiBlast_CBE
44.86
34%
-96
- C1 -
2F7Z
1
KAPCA_BOVIN
E:
[42-317]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
---
M
E
-----
T
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
-
V
K
-
L
K
---
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
A
-
V
-
N
F
P
---
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
--
R
--
F
S
-
E
P
H
A
R
--
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
----
Y
I
Q
V
T
D
F
G
F
---
A
--------
K
-
R
-
V
K
G
R
T
WTLC
G
T
P
E
Y
L
A
P
E
I
I
-
L
S
K
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
-
I
Q
I
Y
E
K
I
V
S
G
K
V
R
---------
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
L
-
K
-
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
---
E
I
R
V
S
I
N
E
K
C
G
K
E
F
S
E
F
---------------------------------------------------------------------------
44
PsiBlast_CBE
44.81
38%
-96
- C1 -
3A61
1
KS6B1_HUMAN
A:
[19-299]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
L
L
R
V
L
G
K
G
G
Y
G
K
V
F
--
Q
V
---
R
K
V
T
GAN
T
G
----
K
I
F
A
M
K
V
L
K
-------------------
A
E
R
N
I
L
-
E
E
-
V
-
K
H
P
---
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
E
G
--
I
-----
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
K
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
H
Q
G
----
H
V
K
L
T
D
F
G
--------------------------
G
T
I
E
Y
M
A
P
E
I
L
-
M
R
S
G
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
P
P
-
F
T
G
E
N
-
R
K
K
T
I
D
K
I
L
K
C
K
L
N
----
L
P
P
Y
L
T
Q
----
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
R
L
G
A
G
-
P
-
G
D
A
G
E
V
Q
A
H
P
F
F
R
H
I
N
W
E
E
L
L
A
R
K
V
E
P
P
F
K
P
----------------------------------------------------------------------------------------------------------------
74
PsiBlast_CBE
44.79
37%
-91
- C1 -
4GUE
1
KS6A3_MOUSE
A:
[25-305]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
Q
F
E
L
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
V
K
----
K
I
-----
S
G
SDAR
Q
L
Y
A
M
K
V
L
K
K
A
T
L
-
K
V
-
R
D
---
R
V
---------
L
-
V
E
-
V
-
N
H
P
---
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
----
E
--
V
M
-
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
S
L
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
G
----
H
I
K
L
T
D
F
G
L
---
S
K
E
------
K
-
K
-
A
Y
S
F
C
----
G
T
V
E
Y
M
A
P
E
V
V
-
N
R
R
G
H
T
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
T
L
P
-
F
Q
G
K
D
-
R
K
----
E
T
M
T
M
I
L
K
----
A
K
L
G
M
P
Q
F
L
S
P
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
R
L
G
A
G
-
P
-
D
G
V
E
E
I
K
R
H
S
F
F
S
T
I
D
W
N
K
L
Y
R
R
E
I
H
P
P
F
K
P
----------------------------------------------------------------------------------------------------------------
49
PsiBlast_CBE
44.36
39%
-92
- C1 -
4L3J
1
KS6B1_HUMAN
A:
[20-304]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
L
L
R
V
L
G
K
G
G
Y
G
K
V
F
--
Q
V
---
R
K
VTGAN
T
G
----
K
I
F
A
M
K
V
L
K
K
A
M
I
V
R
N
-
A
K
---
D
T
A
H
T
K
A
E
R
N
I
L
-
E
E
-
V
-
K
H
P
---
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
E
G
--
I
-----
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
K
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
H
Q
G
----
H
V
K
L
T
D
F
G
L
CKE
S
I
H
----
D
G
T
-
V
-
T
H
T
F
C
----
G
T
I
E
Y
M
A
P
E
I
L
-
M
R
S
G
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
P
P
-
F
T
G
E
N
-
R
K
K
T
I
D
K
I
L
K
C
K
L
N
----
L
P
P
Y
L
T
Q
----
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
R
L
G
A
G
-
P
-
G
D
A
G
E
V
Q
A
H
P
F
F
R
H
I
N
W
E
E
L
L
A
R
K
V
E
P
P
F
K
P
L
L
Q
S
------------------------------------------------------------------------------------------------------------
86
PsiBlast_CBE
44.28
34%
-85
- C1 -
2UZV
1
KAPCA_BOVIN
A:
[27-302]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
---
M
E
-----
T
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
-
V
K
-
L
K
---
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
A
-
V
-
N
F
P
---
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
--
R
--
F
S
-
E
P
H
A
R
--
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
----
Y
I
Q
V
T
D
F
G
F
---
A
--------
K
-
R
-
V
K
G
R
T
W
T
LC
G
T
P
E
Y
L
A
P
E
I
I
-
L
S
K
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
-
I
Q
I
Y
E
K
I
V
S
G
K
V
R
---------
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
L
-
K
-
D
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
---
E
I
R
V
S
I
N
E
K
C
G
K
E
F
S
E
F
---------------------------------------------------------------------------
61
PsiBlast_CBE
44.24
39%
-96
- C1 -
3HDN
1
SGK1_HUMAN
A:
[40-316]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
H
F
L
K
V
I
G
K
G
S
F
G
K
V
L
L
A
R
H
---
K
A
-----
E
E
----
V
F
Y
A
V
K
V
L
Q
K
K
A
I
-
L
-----------------
V
L
-
L
K
N
V
-
K
H
P
---
F
L
V
G
L
H
F
S
F
Q
T
A
D
K
L
Y
F
V
L
D
Y
I
N
G
G
E
L
F
Y
H
L
--
Q
R
--
E
--
R
C
-
F
L
E
P
R
A
R
F
Y
A
A
E
I
A
S
A
L
G
Y
L
H
S
L
N
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
S
Q
G
----
H
I
V
L
T
D
F
G
L
C--
K
E
N
-
I
-
E
H
N
S
-
T
-
T
S
T
F
C
----
G
T
P
E
Y
L
A
P
E
V
L
-
H
K
Q
P
Y
D
R
T
V
D
W
W
C
L
G
A
V
L
Y
E
M
L
Y
G
L
P
P
-
F
Y
S
R
N
-
T
A
----
E
M
Y
D
N
I
L
N
----
K
P
L
Q
L
K
P
N
I
T
N
S
A
R
H
L
L
E
G
L
L
Q
K
D
R
T
K
R
L
G
A
K
---
D
D
F
M
E
I
K
S
H
V
F
F
S
L
I
N
W
D
D
L
I
N
K
K
I
T
P
P
F
N
P
----------------------------------------------------------------------------------------------------------------
48
PsiBlast_CBE
44.06
39%
-89
- C1 -
4L3L
1
KS6B1_HUMAN
A:
[20-304]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
L
L
R
V
L
G
K
G
G
Y
G
K
V
F
--
Q
V
---
R
K
VTGAN
T
G
----
K
I
F
A
M
K
V
L
K
K
A
M
I
V
R
N
-
A
K
---
D
T
A
H
T
K
A
E
R
N
I
L
-
E
E
-
V
-
K
H
P
---
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
E
G
--
I
-----
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
K
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
H
Q
G
----
H
V
K
L
T
D
F
G
L
CKE
S
I
H
----
D
G
T
-
V
-
T
H
T
F
C
----
G
T
I
E
Y
M
A
P
E
I
L
-
M
R
S
G
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
P
P
-
F
T
G
E
N
-
R
K
K
T
I
D
K
I
L
K
C
K
L
N
----
L
P
P
Y
L
T
Q
----
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
R
L
G
A
G
-
P
-
G
D
A
G
E
V
Q
A
H
P
F
F
R
H
I
N
W
E
E
L
L
A
R
K
V
E
P
P
F
K
P
L
L
Q
S
------------------------------------------------------------------------------------------------------------
62
PsiBlast_CBE
43.61
39%
-94
- C1 -
3HDM
1
SGK1_HUMAN
A:
[40-317]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
H
F
L
K
V
I
G
K
G
S
F
G
K
V
L
L
A
R
H
---
K
A
-----
E
E
----
V
F
Y
A
V
K
V
L
Q
K
K
A
I
-
L
-----------------
V
L
-
L
K
N
V
-
K
H
P
---
F
L
V
G
L
H
F
S
F
Q
T
A
D
K
L
Y
F
V
L
D
Y
I
N
G
G
E
L
F
Y
H
L
--
Q
R
--
E
--
R
C
-
F
L
E
P
R
A
R
F
Y
A
A
E
I
A
S
A
L
G
Y
L
H
S
L
N
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
S
Q
G
----
H
I
V
L
T
D
F
G
L
C--
K
E
N
-
I
-
E
H
N
S
-
T
-
T
S
T
F
C
----
G
T
P
E
Y
L
A
P
E
V
L
-
H
K
Q
P
Y
D
R
T
V
D
W
W
C
L
G
A
V
L
Y
E
M
L
Y
G
L
P
P
-
F
Y
S
R
N
-
T
A
----
E
M
Y
D
N
I
L
N
----
K
P
L
Q
L
K
P
N
I
T
N
S
A
R
H
L
L
E
G
L
L
Q
K
D
R
T
K
R
L
G
A
K
---
D
D
F
M
E
I
K
S
H
V
F
F
S
L
I
N
W
D
D
L
I
N
K
K
I
T
P
P
F
N
P
N
V
S
G
------------------------------------------------------------------------------------------------------------
46
PsiBlast_CBE
43.55
38%
-94
- C1 -
3A60
1
KS6B1_HUMAN
A:
[19-299]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
L
L
R
V
L
G
K
G
G
Y
G
K
V
F
--
Q
V
---
R
K
V
T
GAN
T
G
----
K
I
F
A
M
K
V
L
K
K
A
M
---------------
K
A
E
R
N
I
L
-
E
E
-
V
-
K
H
P
---
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
E
G
--
I
-----
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
K
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
H
Q
G
----
H
V
K
L
T
D
F
G
L
CKE-----------------------
T
I
E
Y
M
A
P
E
I
L
-
M
R
S
G
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
P
P
-
F
T
G
E
N
-
R
K
K
T
I
D
K
I
L
K
C
K
L
N
----
L
P
P
Y
L
T
Q
----
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
R
L
G
A
G
-
P
-
G
D
A
G
E
V
Q
A
H
P
F
F
R
H
I
N
W
E
E
L
L
A
R
K
V
E
P
P
F
K
P
----------------------------------------------------------------------------------------------------------------
42
PsiBlast_CBE
42.09
39%
-83
- C1 -
4L44
1
KS6B1_HUMAN
A:
[20-304]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
L
L
R
V
L
G
K
G
G
Y
G
K
V
F
--
Q
V
---
R
K
VTGAN
T
G
----
K
I
F
A
M
K
V
L
K
K
A
M
I
V
R
N
-
A
K
---
D
T
A
H
T
K
A
E
R
N
I
L
-
E
E
-
V
-
K
H
P
---
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
E
G
--
I
-----
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
K
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
H
Q
G
----
H
V
K
L
T
D
F
G
L
CKE
S
I
H
-----------
H
T
F
C
----
G
T
I
E
Y
M
A
P
E
I
L
-
M
R
S
G
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
P
P
-
F
T
G
E
N
-
R
K
K
T
I
D
K
I
L
K
C
K
L
N
----
L
P
P
Y
L
T
Q
----
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
R
L
G
A
G
-
P
-
G
D
A
G
E
V
Q
A
H
P
F
F
R
H
I
N
W
E
E
L
L
A
R
K
V
E
P
P
F
K
P
L
L
Q
S
E
E
D
V
S
Q
D
S
K
F
T
R
Q
---
T
S
E
S
A
N
Q
V
F
L
G
F
A
Y
V
A
P
S
--------------------------------------------------------------------------
50
PsiBlast_CBE
40.52
39%
-97
- C1 -
4RLO
4
KS6B1_HUMAN
B:
[7-287]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
L
L
R
V
L
G
K
G
G
Y
G
K
V
F
--
Q
V
---
R
K
VTGAN
T
G
----
K
I
F
A
M
K
V
L
K
K
------------------------------
K
H
P
---
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
E
G
--
I
-----
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
K
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
H
Q
G
----
H
V
K
L
T
D
F
G
L
CKE
S
I
---------------------
T
I
E
Y
M
A
P
E
I
L
-
M
R
S
G
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
P
P
-
F
T
G
E
N
-
R
K
K
T
I
D
K
I
L
K
C
K
L
N
----
L
P
P
Y
L
T
Q
----
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
R
L
G
A
G
-
P
-
G
D
A
G
E
V
Q
A
H
P
F
F
R
H
I
N
W
E
E
L
L
A
R
K
V
E
P
P
F
K
P
L
---------------------------------------------------------------------------------------------------------------
124
HHSearch
40.23
32%
-92
- C1 -
2Y0A
1
DAPK1_HUMAN
A:
[11-284]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Y
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
---
K
S
-----
T
G
----
L
Q
Y
A
A
K
F
I
K
K
R
R
T
-
K
S
-
S
R
RGV
S
R
E
D
I
E
R
E
V
S
I
L
-
K
E
-
I
-
Q
H
P
---
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
----
K
--
E
S
-
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
VP
K
P
R
I
K
I
I
D
F
G
L
---
A
H
K
-
I
-
D
F
G
N
-
E
-
F
K
N
I
F
----
G
T
P
E
F
V
A
P
E
I
V
-
N
Y
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
-
F
L
G
D
T
-
K
----
Q
E
T
L
A
N
V
S
A
VNYE
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
-------
T
I
Q
D
S
L
Q
H
P
W
I
K
P
K
D
T
Q
Q
A
L
S
R
K
A
S
A
V
N
M
E
K
F
K
K
F
A
A
R
--------------------------------------------------------------------------------------------------------
45
PsiBlast_CBE
40.04
38%
-92
- C1 -
3A60
1
KS6B1_HUMAN
B:
[19-300]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
L
L
R
V
L
G
K
G
G
Y
G
K
V
F
--
Q
V
---
R
K
VTGAN
T
G
----
K
I
F
A
M
K
V
L
K
K
------------------------------
K
H
P
---
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
E
G
--
I
-----
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
K
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
H
Q
G
----
H
V
K
L
T
D
F
G
L
CKE
S
----------------
C
----
G
T
I
E
Y
M
A
P
E
I
L
-
M
R
S
G
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
P
P
-
F
T
G
E
N
-
R
K
K
T
I
D
K
I
L
K
C
K
L
N
----
L
P
P
Y
L
T
Q
----
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
R
L
G
A
G
-
P
-
G
D
A
G
E
V
Q
A
H
P
F
F
R
H
I
N
W
E
E
L
L
A
R
K
V
E
P
P
F
K
P
L
---------------------------------------------------------------------------------------------------------------