@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : HIPK1_HUMAN: (2015-10-08 )
MASQLQVFSPPSVSSSAFCSAKKLKIEPSGWDVSGQSSNDKYYTHSKTLPATQGQANSSHQVANFNIPAYDQGLLLPAPAVEHIVVTAADSSGSAATSTFQSSQTLTHRSNVSLLEPYQKCGLKRKSEEVDSNGSVQIIEEHPPLMLQNRTVVGAAATTTTVTTKSSSSSGEGDYQLVQHEILCSMTNSYEVLEFLGRGTFGQVAKCWKRSTKEIVAIKILKNHPSYARQGQIEVSILSRLSSENADEYNFVRSYECFQHKNHTCLVFEMLEQNLYDFLKQNKFSPLPLKYIRPILQQVATALMKLKSLGLIHADLKPENIMLVDPVRQPYRVKVIDFGSASHVSKAVCSTYLQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGASEYDQIRYISQTQGLPAEYLLSAGTKTTRFFNRDPNLGYPLWRLKTPEEHELETGIKSKEARKYIFNCLDDMAQVNMSTDLEGTDMLAEKADRREYIDLLKKMLTIDADKRITPLKTLNHQFVTMTHLLDFPHSNHVKSCFQNMEICKRRVHMYDTVSQIKSPFTTHVAPNTSTNLTMSFSNQLNTVHNQASVLASSSTAAAATLSLANSDVSLLNYQSALYPSSAAPVPGVAQQGVSLQPGTTQICTQTDPFQQTFIVCPPAFQTGLQATTKHSGFPVRMDNAVPIVPQAPAAQPLQIQSGVLTQGSCTPLMVATLHPQVATITPQYAVPFTLSCAAGRPALVEQTAAVLQAWPGGTQQILLPSTWQQLPGVALHNSVQPTAMIPEAMGSGQQLADWRNAHSHGNQYSTIMQQPSLLTNHVTLATAQPLNVGVAHVVRQQQSSSLPSKKNKQSAPVSSKSSLDVLPSQVYSLVGSSPLRTTSSYNSLVPVQDQHQPIIIPDTPSPPVSVITIRSDTDEEEDNKYKPSSSGLKPRSNVISYVTVNDSPDSDSSLSSPYSTDTLSALRGNSGSVLEGPGRVVADGTGTRTIIVPPLKTQLGDCTVATQASGLLSNKTKPVASVSGQSSGCCITPTGYRAQRGGTSAAQPLNLSQNQQSSAAPTSQERSSNPAPRRQQAFVAPLSQAPYTFQHGSPLHSTGHPHLAPAPAHLPSQAHLYTYAAPTSAAALGSTSSIAHLFSPQGSSRHAAAYTTHPSTLVHQVPVSVGPSLLTSASVAPAQYQHQFATQSYIGSSRGSTIYTGYPLSPTKISQYSYL
Atome Classification :
(7 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200..--.....-210.......220.......230.......240.....-.-.250.......260.......270.......280........290.......300......--.310.......320....-------...330------.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480...----....490----.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770.......780.......790.......800.......810.......820.......830.......840.......850.......860.......870.......880.......890.......900.......910.......920.......930.......940.......950.......960.......970.......980.......990.......1000......1010......1020......1030......1040......1050......1060......1070......1080......1090......1100......1110......1120......1130......1140......1150......1160......1170......1180......1190......1200......1210
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MASQ
L
Q
VFSPPSVSSSAFCSA
K
K
L
K
IEPSGWDVSGQSSND
K
Y
Y
T
HSKTLPATQGQANSS
H
Q
V
A
NFNIPAYDQGLLLPAPAV
E
H
I
V
V
T
AADSSGSAA
T
S
TFQSSQTLTHRSN
V
S
L
L
E
P
Y
Q
K
CGLKRKSEEVDSNG
S
V
Q
I
IEEHP
P
L
M
L
QN
R
T
V
V
GAA
A
T
T
T
T
V
T
TKSSSSSGEG
D
Y
Q
L
V
Q
H
E
I
L
C
SMT
N
S
Y
E
V
L
E
F
LGRG
T
F
G
Q
V
--
A
K
C
W
K
-RSTK
E
I
V
A
I
K
I
LKNHPSYARQGQ
I
E
V
S
I
L
S
R
LSSENAD-
E
-
Y
N
F
V
R
S
Y
E
C
F
QHKNH
T
C
L
V
F
E
M
L
E
Q
N
L
Y
D
F
L
K
Q-NKFSPL
P
L
K
Y
I
R
P
I
L
Q
Q
V
A
T
A
L
M
K
L
K
S--LG
L
I
HADLKPE
N
I
M
L
VDP-------VRQ
P
Y
R
------
V
K
V
I
DFG
S
A
S
H
V
S
K
A
V
C
S
T
Y
L
Q
S
R
YYRAPE
I
I
L
GL
P
F
C
E
A
I
D
M
W
S
L
G
C
V
I
A
E
L
F
LGWPLYPGASE
Y
D
Q
I
R
Y
I
S
QTQGL
P
A
E
Y
L
L
SAGTK
T
T
R
FFNRDPNLGYP
L
W
RLKTP
E
E
H
E
L
E
TGI
K
S
K
E
A
R
K
Y
I
F
N
C
L
D
D
M
A
QVNMSTDLE
G
T
D
M
L
A
E
K
----
A
D
R
R
E
Y
I
----
D
L
L
K
K
M
L
TIDADKRIT
P
L
K
TLN
H
Q
F
V
T
M
T
H
L
LDFPHS
N
H
V
K
S
C
F
Q
N
M
E
I
C
K
R
R
V
H
M
Y
D
T
V
S
Q
I
KSPFTTHVAPNTST
N
L
T
M
S
FSNQL
N
T
V
H
N
Q
A
S
V
LASSSTA
A
A
A
T
L
S
LANSD
V
S
L
L
N
Y
Q
SALYPSSAAPVPG
V
A
QQGVSLQPGT
T
Q
I
CTQTDPF
Q
Q
T
F
I
VC
P
P
A
F
Q
T
G
L
Q
ATTKHSGF
P
V
RMDNAVPIVPQAPAAQ
P
L
Q
I
QS
G
V
LTQGSCT
P
L
M
V
A
TLHP
Q
V
A
TITPQYAV
P
F
T
L
SCAAGR
P
A
L
V
E
Q
T
A
A
V
L
Q
AWPGGT
Q
Q
I
LL
P
S
T
W
Q
QLPGVALHNSVQPTAM
I
P
E
AMGSG
Q
Q
L
A
D
W
R
N
AHSHGN
Q
Y
S
T
I
M
QQP
S
L
LTN
H
V
T
L
ATAQPL
N
V
G
V
A
H
V
V
R
Q
Q
Q
SSSLPSKKNKQSAPVSSKSS
L
D
V
L
P
S
Q
V
Y
S
L
VGSSPLRTTSSYNSLVPVQDQHQ
P
I
I
IPDTPSP
P
V
S
V
I
T
IRSDTDEEEDNKYKPSSSGLKPRS
N
V
I
S
Y
V
T
VNDSPDSDSSLSSPYSTD
T
L
S
A
LRGNSGSVLEGP
G
R
V
V
ADGTG
T
R
T
I
I
VPPLKTQLGD
C
T
V
A
T
Q
A
S
G
LLSNKTKP
V
A
SVSGQSSG
C
C
ITPTGYRAQRGGTSAAQPLNLSQNQQSSAAPTSQERSSNPAPR
R
Q
Q
A
F
VAPLSQA
P
Y
TFQHGSPLHSTGHPHLAPAPAHLPSQA
H
L
Y
T
YAAPT
S
A
AALGSTS
S
I
A
H
L
FSPQGSSR
H
A
A
A
YTTH
P
S
T
L
V
H
QVPVSV
G
P
S
L
LTSASVA
P
A
Q
Y
Q
H
Q
F
A
T
Q
S
YIGSSRG
S
T
I
Y
TGYPLSP
T
K
ISQYSYL
13
PsiBlast_PDB
89.11
38%
-87
- C2 -
4AZE
1
DYR1A_HUMAN
A:
[54-378]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
R
Y
E
I
D
S
L
I
G
K
G
S
F
G
Q
V
--
V
K
A
Y
D
-
R
V
E
Q
E
W
V
A
I
K
I
I
K
N
K
K
A
F
L
N
Q
A
Q
I
E
V
R
L
L
E
L
M
N
K
H
D
T
E
M
K
-
Y
Y
I
V
H
L
K
R
H
F
M
F
R
N
H
L
C
L
V
F
E
M
L
S
Y
N
L
Y
D
L
L
R
N
-
T
N
F
R
G
V
S
L
N
L
T
R
K
F
A
Q
Q
M
C
T
A
L
L
F
L
A
T
PE
L
S
I
I
H
C
D
L
K
P
E
N
I
L
L
C
N
P
-------
K
R
S
A
--------
I
K
I
V
D
F
G
S
S
C
Q
L
G
Q
R
I
Y
Q
Y
-
I
Q
S
R
F
Y
R
S
P
E
V
L
L
G
M
P
Y
D
L
A
I
D
M
W
S
L
G
C
I
L
V
E
M
H
T
G
E
P
L
F
S
G
A
N
E
V
D
Q
M
N
K
I
V
E
V
L
G
I
P
P
A
H
I
L
D
Q
A
P
K
A
R
K
F
F
E
K
L
P
D
---
G
T
W
N
L
K
K
T
K
D
G
K
R
E
--
Y
K
P
P
G
T
R
K
-
L
H
N
I
L
------
G
V
E
T
G
G
P
G
G
R
R
A
G
E
S
G
H
T
V
A
D
Y
L
K
F
K
----
D
L
I
L
R
M
L
D
Y
D
P
K
T
R
I
Q
P
Y
Y
A
L
Q
H
S
F
F
K
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
44
PsiBlast_CBE
88.32
38%
-88
* C2 *
2WO6
1
DYR1A_HUMAN
B:
[54-377]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
R
Y
E
I
D
S
L
I
G
K
G
S
F
G
Q
V
--
V
K
A
Y
D
-
R
V
E
Q
E
W
V
A
I
K
I
I
K
N
K
K
A
F
L
N
Q
A
Q
I
E
V
R
L
L
E
L
M
N
K
H
D
T
E
M
K
-
Y
Y
I
V
H
L
K
R
H
F
M
F
R
N
H
L
C
L
V
F
E
M
L
S
Y
N
L
Y
D
L
L
R
N
-
T
N
F
R
G
V
S
L
N
L
T
R
K
F
A
Q
Q
M
C
T
A
L
L
F
L
A
T
PE
L
S
I
I
H
C
D
L
K
P
E
N
I
L
L
C
N
P
-------
K
R
S
A
--------
I
K
I
V
D
F
G
S
S
C
Q
L
G
Q
R
I
Y
Q
Y
-
I
Q
S
R
F
Y
R
S
P
E
V
L
L
G
M
P
Y
D
L
A
I
D
M
W
S
L
G
C
I
L
V
E
M
H
T
G
E
P
L
F
S
G
A
N
E
V
D
Q
M
N
K
I
V
E
V
L
G
I
P
P
A
H
I
L
D
Q
A
P
K
A
R
K
F
F
E
K
L
P
D
---
G
T
W
N
L
K
K
-----
R
E
--
Y
K
P
P
G
T
R
K
-
L
H
N
I
L
------
G
V
E
T
G
G
P
G
G
R
R
A
G
E
S
GH
T
V
A
D
Y
L
K
F
K
----
D
L
I
L
R
M
L
D
Y
D
P
K
T
R
I
Q
P
Y
Y
A
L
Q
H
S
F
F
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
85.80
38%
-86
- C2 -
2WO6
1
DYR1A_HUMAN
A:
[54-378]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
R
Y
E
I
D
S
L
I
G
K
G
S
F
G
Q
V
--
V
K
A
Y
D
-
R
V
E
Q
E
W
V
A
I
K
I
I
K
N
K
K
A
F
L
N
Q
A
Q
I
E
V
R
L
L
E
L
M
N
K
H
D
T
E
M
K
-
Y
Y
I
V
H
L
K
R
H
F
M
F
R
N
H
L
C
L
V
F
E
M
L
S
Y
N
L
Y
D
L
L
R
N
-
T
N
F
R
G
V
S
L
N
L
T
R
K
F
A
Q
Q
M
C
T
A
L
L
F
L
A
T
PE
L
S
I
I
H
C
D
L
K
P
E
N
I
L
L
C
N
P
-------
K
R
S
A
--------
I
K
I
V
D
F
G
S
S
C
Q
L
G
Q
R
I
Y
Q
Y
-
I
Q
S
R
F
Y
R
S
P
E
V
L
L
G
M
P
Y
D
L
A
I
D
M
W
S
L
G
C
I
L
V
E
M
H
T
G
E
P
L
F
S
G
A
N
E
V
D
Q
M
N
K
I
V
E
V
L
G
I
P
P
A
H
I
L
D
Q
A
P
K
A
R
K
F
F
E
K
L
P
D
---
G
T
W
N
L
K
K
T
----
R
E
--
Y
K
P
P
G
T
R
K
-
L
H
N
I
L
------
G
V
E
T
G
G
P
G
G
R
R
A
G
E
S
GH
T
V
A
D
Y
L
K
F
K
----
D
L
I
L
R
M
L
D
Y
D
P
K
T
R
I
Q
P
Y
Y
A
L
Q
H
S
F
F
K
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
78.23
30%
-90
- C2 -
2VAG
1
CLK1_HUMAN
A:
[12-334]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
A
R
Y
E
I
V
D
T
L
G
E
G
A
F
G
K
V
--
V
E
C
I
D
H
K
A
G
G
R
H
V
A
V
K
I
V
K
N
V
D
R
Y
C
E
A
A
R
S
E
I
Q
V
L
E
H
L
N
T
T
D
P
N
-
S
T
F
R
C
V
Q
M
L
E
W
F
E
H
H
G
H
I
C
I
V
F
E
L
L
G
L
S
T
Y
D
F
I
K
E
-
N
G
F
L
P
F
R
L
D
H
I
R
K
M
A
Y
Q
I
C
K
S
V
N
F
L
H
S
--
N
K
L
T
H
T
D
L
K
P
E
N
I
L
F
V
Q
S
D
Y
T
E
A
Y
N-
K
R
D
E
R
T
L
INP
D
I
K
V
V
D
F
G
S
A
T
Y
D
D
E
H
-
H
S
T
L
V
S
T
R
H
Y
R
A
P
E
V
I
L
A
L
G
W
S
Q
P
C
D
V
W
S
I
G
C
I
L
I
E
Y
Y
L
G
F
T
V
F
P
T
H
D
S
K
E
H
L
A
M
M
E
R
I
L
G
P
L
P
K
H
M
I
Q
K
-
T
R
K
R
K
Y
F
H
H
D
--------
R
L
D
W
-
D
E
H
S
--------
S
A
G
R
Y
V
S
R
A
C
K
P
L
K
E
F
M
L
S
Q
D
V
E
--------------
H
E
R
L
F
----
D
L
I
Q
K
M
L
E
Y
D
P
A
K
R
I
T
L
R
E
A
L
K
H
P
F
F
D
L
L
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
76.09
30%
-89
- C2 -
1Z57
1
CLK1_HUMAN
A:
[12-334]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
A
R
Y
E
I
V
D
T
L
G
E
G
A
F
G
K
V
--
V
E
C
I
D
H
K
A
G
G
R
H
V
A
V
K
I
V
K
N
V
D
R
Y
C
E
A
A
R
S
E
I
Q
V
L
E
H
L
N
T
T
D
P
N
-
S
T
F
R
C
V
Q
M
L
E
W
F
E
H
H
G
H
I
C
I
V
F
E
L
L
G
L
S
T
Y
D
F
I
K
E
-
N
G
F
L
P
F
R
L
D
H
I
R
K
M
A
Y
Q
I
C
K
S
V
N
F
L
H
S
--
N
K
L
T
H
T
D
L
K
P
E
N
I
L
F
V
Q
S
D
Y
T
E
A
Y
N--
R
D
E
R
T
L
INP
D
I
K
V
V
D
F
G
S
A
T
Y
D
D
E
H
-
H
S
T
L
V
S
T
R
H
Y
R
A
P
E
V
I
L
A
L
G
W
S
Q
P
C
D
V
W
S
I
G
C
I
L
I
E
Y
Y
L
G
F
T
V
F
P
T
H
D
S
K
E
H
L
A
M
M
E
R
I
L
G
P
L
P
K
H
M
I
Q
K
-
T
R
K
R
K
Y
F
H
H
D
--------
R
L
D
W
-
D
E
H
S
--------
S
A
G
R
Y
V
S
R
A
C
K
P
L
K
E
F
M
L
S
Q
D
V
E
--------------
H
E
R
L
F
----
D
L
I
Q
K
M
L
E
Y
D
P
A
K
R
I
T
L
R
E
A
L
K
H
P
F
F
D
L
L
K
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
72.03
32%
-78
- C2 -
4IFC
1
PRP4B_HUMAN
A:
[14-348]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
D
A
E
G
Y
Y
R
V
N
I
G
E
V
L
---
D
K
R
Y
N
V
Y
G
Y
T
G
Q
G
V
F
S
N
V
V
R
A
R
D
N
A
-
R
A
N
Q
E
-
V
A
V
K
I
I
R
N
N
E
L
M
Q
K
T
G
L
K
E
L
E
F
L
K
K
L
N
D
A
D
P
D
-
D
K
F
H
C
L
R
L
F
R
H
F
Y
H
K
Q
H
L
C
L
V
F
E
P
L
S
M
N
L
R
E
V
L
K
K
Y
G
K
D
V
G
L
H
I
K
A
V
R
S
Y
S
Q
Q
L
F
L
A
L
K
L
L
K
R
--
C
N
I
L
H
A
D
I
K
P
D
N
I
L
V
N
E
----------
S
K
T
I
------
L
K
L
C
D
F
G
S
A
S
H
V
A
D
N
D
I
T
P
Y
L
V
S
R
F
Y
R
A
P
E
I
I
I
G
K
S
Y
D
Y
G
I
D
M
W
S
V
G
C
T
L
Y
E
L
Y
T
G
K
I
L
F
P
G
K
T
N
N
H
M
L
K
L
A
M
D
L
K
G
K
M
P
N
K
M
I
R
K
G
V
F
K
D
Q
H
F
--
D
Q
N
L
N
F
M
Y
I
E
------
R
E
K
V
T
V
M
S
T
I
N
P
T
K
------------
D
L
L
A
D
L
I
----
L
P
E
------
D
Q
R
K
K
V
H
Q
L
K
D
L
L
D
Q
I
L
M
L
D
P
A
K
R
I
S
I
N
Q
A
L
Q
H
A
F
I
Q
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
58.10
38%
-48
- C2 -
4YLK
13
DYR1A_HUMAN
A:
[33-357]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
R
Y
E
I
D
S
L
I
G
K
G
S
F
G
Q
V
--
V
K
A
Y
D
-
R
V
E
Q
E
W
V
A
I
K
I
I
K
N
K
K
A
F
L
N
Q
A
Q
I
E
V
R
L
L
E
L
M
N
K
H
D
T
E
M
K
-
Y
Y
I
V
H
L
K
R
H
F
M
F
R
N
H
L
C
L
V
F
E
M
L
S
Y
N
L
Y
D
L
L
R
N
-
T
N
F
R
G
V
S
L
N
L
T
R
K
F
A
Q
Q
M
C
T
A
L
L
F
L
A
T
PE
L
S
I
I
H
C
D
L
K
P
E
N
I
L
L
C
N
P
-------
K
R
S
A
--------
I
K
I
V
D
F
G
S
S
C
Q
L
G
Q
R
I
Y
Q
Y
-
I
Q
S
R
F
Y
R
S
P
E
V
L
L
G
M
P
Y
D
L
A
I
D
M
W
S
L
G
C
I
L
V
E
M
H
T
G
E
P
L
F
S
G
A
N
E
V
D
Q
M
N
K
I
V
E
V
L
G
I
P
P
A
H
I
L
D
Q
A
P
K
A
R
K
F
F
E
K
L
P
D
---
G
T
W
N
L
K
K
------
E
--
Y
K
P
P
G
T
R
K
-
L
H
N
I
L
------
G
V
E
T
G
G
P
G
G
R
R
A
G
E
S
GH
T
V
A
D
Y
L
K
F
K
----
D
L
I
L
R
M
L
D
Y
D
P
K
T
R
I
Q
P
Y
Y
A
L
Q
H
S
F
F
K
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------